RNF115 Gene
protein-coding GIFtS: 49
GCID: GC01P145611
|
|
ring finger protein 115(Previous name: zinc finger protein 364 )
(Previous symbol: ZNF364)
| |
Aliases
for RNF115 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1151 2 3 | | CL4697801 | | Zinc Finger Protein 3641 2 3 | | BCA22 | | ZNF3641 2 3 | | E3 Ubiquitin-Protein Ligase RNF1152 | | Rabring 72 3 | | EC 6.3.2.-3 |
Export aliases for RNF115 gene to outside databasesPrevious GC identifers: GC01P144323 GC01P119574 |
Summaries
for RNF115 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5Function: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking
Gene Wiki entry for RNF115 (ZNF364)
|
Genomic Views
for RNF115 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167185.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF115 gene promoter:
Sox5 AML1a Pax-2 Pax-2a CREB AREB6 S8 FOXO4 deltaCREB Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF115
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF115 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q12RNF115 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P145611: view genomic region
(about GC identifiers)
Start:
|
145,611,036 bp from pter |
End:
|
145,690,661 bp from pter |
Size:
|
79,626 bases |
Orientation:
|
plus strand |
|
Proteins
for RNF115 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF115 Size: 304 amino acids; 33703 Da
Subunit: Interacts with RAB7A
Subcellular location: Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from thecytosol onto late endosomes/lysosomes (By similarity)
Secondary accessions: A8K3Y4 Q5T2V9 Q7Z2J2Explore the universe of human proteins at neXtProt for RNF115: NX_Q9Y4L5
Post-translational modifications:
RING-type zinc finger-dependent and E2-dependent autoubiquitination1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4L5
RNF115 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055270.1
ENSEMBL proteins: ENSP00000358297 ENSP00000444901 ENSP00000442099
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
ISS | -- |
RNF115 for ontologies About GeneDecksing
RNF115 Antibody Products:
Assay Products for RNF115: |
Protein
Domains /
Families
for RNF115 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF115 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y4L5ProtoNet protein and cluster: Q9Y4L5 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5Similarity: Contains 1 RING-type zinc finger |
Function
for RNF115 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5Function: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic traffickingEnzyme Number (IUBMB): EC 6.3.2.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF115 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF115 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RNF115 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF115 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF115 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RNF115 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RNF115:
|
Pathways & Interactions
for RNF115 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5Pathway: Protein modification; protein ubiquitinationInteractions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF115
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/16 Interacting proteins for RNF115 (Q9Y4L53 ENSP000003582974) via UniProtKB, MINT, STRING, and/or I2D (see all 16) About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
RNF115 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF115 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF115
Search CenterWatch for drugs/clinical trials and news about RNF115 / RN115
|
Transcripts
for RNF115 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF115 gene: NM_014455.2 Unigene Cluster for RNF115: Ring finger protein 115 Hs.523550 [show with all ESTs]Unigene Representative Sequence: NM_0144553 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369291(uc001eoj.3) ENST00000539368 ENST00000542738
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF115 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF115 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF115 (NM_014455) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF115 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF115 |
Additional cDNA sequence: AF419857.1 AF542552.1 AK290749.1 AL079312.1 AL079314.1 BC054049.2 BC064903.1 15 DOTS entries: DT.100774455 DT.95339042 DT.70103706 DT.415520 DT.95168074 DT.415522 DT.100776331 DT.115477 DT.100792758 DT.121439318 DT.121439390 DT.91755159 DT.95168072 DT.95168076 DT.95168075 24/127 AceView cDNA sequences (see all 127): BU180855 CR620298 BX399452 BU783753 BQ431230 CF128540 AI720658 AJ709489 AI478152 BF237759 BX381719 BU155268 CR596995 BQ225386 BE018378 CR597781 AI754535 AW768287 AI244202 BQ421607 AL079314 AI041253 BC064903 BQ189554
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF115 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
|---|
|
| SP1: | | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF115
|
Expression
for RNF115 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF115 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCCTTGTA
About this image
See RNF115 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF115
SOURCE GeneReport for Unigene cluster: Hs.523550
UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5Tissue specificity: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels ofexpression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells
SABiosciences Expression via Pathway-Focused PCR Array including RNF115:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF115
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF115 |
Orthologs
for RNF115 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RNF115 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
RNF1156 |
-- |
75(a) |
1 ↔ 1 |
GL344903.1(12512-15275) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.221422 |
Xenopus laevis transcribed sequence with weak similarity more |
73.99(n) |
|
BQ736630.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.151412 |
Transcribed sequence with weak similarity to protein more |
75.74(n) |
|
AL914996.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG119821 |
CG11982 |
44.88(n)
38.52(a) |
|
41080 NM_141602.3 NP_649859.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G199501 |
E3 ubiquitin-protein ligase RING1-like protein |
41.94(n)
31.54(a) |
|
821533 NM_112885.4 NP_188629.1 |
rice
(Oryza sativa) |
Liliopsida |
Os06g01013001 |
hypothetical protein |
43.78(n)
36.14(a) |
|
4339830 NM_001063064.1 NP_001056529.1 |
ENSEMBL Gene Tree for RNF115 (if available)
TreeFam Gene Tree for RNF115 (if available) |
Paralogs
for RNF115 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF115 gene
- PJA22 RNF1812 RNF1262 PJA12
2 SIMAP similar genes for RNF115 using alignment to 3 protein entries: RN115_HUMAN (see all proteins):RNF126 RNF181
RNF115 for paralogs About GeneDecksing
|
Genomic Variants
for RNF115 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF115 (145611036 - 145690661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for RNF115
10 CNVs: 8923 9894 6783 53388 3311 29579 48114 48115 2325 53561 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF115 |
|
Disorders
/ Diseases
for RNF115 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF115 for disorders About GeneDecksing
7  diseases for RNF115: About MalaCardsalcohol withdrawal delirium hepatitis b alcoholism prostate cancer
breast cancer hepatitis prostatitis
Human Genome Epidemiology (HuGE) Navigator: RNF115 (2 documents)
Export disorders for RNF115 gene to outside databases
|
Publications
for RNF115 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF115 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with RNF115) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration. (PubMed id 18819927)1, 2 Amemiya Y....Seth A. (2008)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Novel RING E3 ubiquitin ligases in breast cancer. (PubMed id 16925951)1, 2 Burger A....Seth A.K. (2006)
- A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer. (PubMed id 16288031)1, 2 Burger A.M....Seth A.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Effects of partner proteins on BCA2 RING ligase activi ty. (PubMed id 22315970)1 Bacopulos S....Seth A.K. (2012)
- Transcriptional activation of breast cancer-associated gene 2 by estrogen receptor. (PubMed id 22850893)1 Kona F.R....Dou Q.P. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Rabring7 degrades c-Myc through complex formation with MM-1. (PubMed id 22844532)1 Narita R....Iguchi-Ariga S.M. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for RNF115 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF115 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF115 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF115 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF115 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF115 gene:
Search GeneIP for patents involving RNF115
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF115 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RNF115 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF115 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF115 | | | OriGene Protein Over-expression Lysate for RNF115 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNF115 | | OriGene 3'-UTR Clone for RNF115 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF115 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF115 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 |
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 | | | RNF115 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF115 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF115 |
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