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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF115 Gene

protein-coding   GIFtS: 51
GCID: GC01P145611

Ring Finger Protein 115

(Previous name: zinc finger protein 364)
(Previous symbol: ZNF364)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1151 2 3     BCA22
Zinc Finger Protein 3641 2 3     E3 Ubiquitin-Protein Ligase RNF1152
ZNF3641 2 3     EC 6.3.2.-3
Rabring 72 3     

External Ids:    HGNC: 181541   Entrez Gene: 272462   Ensembl: ENSG000001218487   UniProtKB: Q9Y4L53   

Export aliases for RNF115 gene to outside databases

Previous GC identifers: GC01P144323 GC01P119574


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF115 Gene: 
RNF115 (ring finger protein 115) is a protein-coding gene. Diseases associated with RNF115 include alcoholism, and hepatitis b. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding. An important paralog of this gene is PJA2.

UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5
Function: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking

Gene Wiki entry for RNF115 (ZNF364) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167185.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF115 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   CREB   AREB6   S8   FOXO4   deltaCREB   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF115 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF115

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF115


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q12

RNF115 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF115 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P145611:  view genomic region     (about GC identifiers)

Start:
145,611,036 bp from pter      End:
145,690,661 bp from pter
Size:
79,626 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF115  
Size: 304 amino acids; 33703 Da
Subunit: Interacts with RAB7A
Subcellular location: Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from
the cytosol onto late endosomes/lysosomes (By similarity)
Secondary accessions: A8K3Y4 Q5T2V9 Q7Z2J2

Explore the universe of human proteins at neXtProt for RNF115: NX_Q9Y4L5

Explore proteomics data for RNF115 at MOPED 

Post-translational modifications:

  • UniProtKB: RING-type zinc finger-dependent and E2-dependent autoubiquitination
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4L5

  • RNF115 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF115 Protein Expression
    REFSEQ proteins: NP_055270.1  
    ENSEMBL proteins: 
     ENSP00000358297   ENSP00000444901   ENSP00000442099  

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    Cloud-Clone Corp. Proteins for RNF115 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--

    RNF115 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y4L5

    ProtoNet protein and cluster: Q9Y4L5

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5
    Similarity: Contains 1 RING-type zinc finger


    RNF115 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN115_HUMAN, Q9Y4L5
    Function: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA18819927
    GO:0005515protein binding IPI16925951
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF115 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF115:
     Cell cycle / mitosis defect  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRNF115 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF115

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/16 Interacting proteins for RNF115 (Q9Y4L53 ENSP000003582974) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSSCA1O602323, ENSP000003123184I2D: score=5 STRING: ENSP00000312318
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051865protein autoubiquitination IDA16288031

    RNF115 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF115 (RN115)

    Search CenterWatch for drugs/clinical trials and news about RNF115 / RN115

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF115 gene: 
    NM_014455.3  

    Unigene Cluster for RNF115:

    Ring finger protein 115
    Hs.523550  [show with all ESTs]
    Unigene Representative Sequence: NM_014455
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369291(uc001eoj.3) ENST00000539368 ENST00000542738
    miRNA
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    hsa-miR-146a* hsa-miR-3163 hsa-miR-214 hsa-miR-513a-3p hsa-miR-3935 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRNF115 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF115

    Additional mRNA sequence: 

    AF419857.1 AF542552.1 AK290749.1 AL079312.1 AL079314.1 BC054049.2 BC064903.1 

    15 DOTS entries:

    DT.100774455  DT.95339042  DT.70103706  DT.415520  DT.95168074  DT.415522  DT.100776331  DT.115477 
    DT.100792758  DT.121439318  DT.121439390  DT.91755159  DT.95168072  DT.95168076  DT.95168075 

    24/127 AceView cDNA sequences (see all 127):

    CF128540 AL079314 BQ421607 AI698257 BQ189554 BE018378 BU180855 BX399452 
    AI244202 AW889253 BC064903 BQ431230 AW768287 BQ225386 CR620298 AI937571 
    BU783753 AI041253 CR596995 BF237759 AI478152 BX381719 BU155268 AI720658 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF115    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                    -           -                                   -                           
    SP2:                    -                                               -                           
    SP3:                                -                                   -                           
    SP4:                                -           -                                                   
    SP5:                                                                                                


    ECgene alternative splicing isoforms for RNF115

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF115 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCCTTGTA
    RNF115 Expression
    About this image


    See RNF115 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF115

    SOURCE GeneReport for Unigene cluster: Hs.523550

    UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5
    Tissue specificity: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of
    expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells

        SABiosciences Expression via Pathway-Focused PCR Array including RNF115: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF115 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1151 , 5 ring finger protein 1151, 5 90.9(n)1
    93.09(a)1
      3 (41.96 cM)5
    678451  NM_026406.31  NP_080682.31 
     967276115 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1156
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL344903.1(12512-15275)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.221422 Xenopus laevis transcribed sequence with weak similarity more 73.99(n)    BQ736630.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151412 Transcribed sequence with weak similarity to protein more 75.74(n)    AL914996.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119821 CG11982 44.88(n)
    38.52(a)
      41080  NM_141602.3  NP_649859.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.36
    Protein Y54E10BR.3
    16(a)
    1 → many
    I(3021649-3028384)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G199501 E3 ubiquitin-protein ligase RING1-like protein 41.94(n)
    31.54(a)
      821533  NM_112885.4  NP_188629.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01013001 hypothetical protein 43.78(n)
    36.14(a)
      4339830  NM_001063064.1  NP_001056529.1 


    ENSEMBL Gene Tree for RNF115 (if available)
    TreeFam Gene Tree for RNF115 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF115 gene
    PJA22  RNF1812  RNF1262  PJA12  
    2 SIMAP similar genes for RNF115 using alignment to 3 protein entries:     RN115_HUMAN (see all proteins):
    RNF126    RNF181

    RNF115 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/912 SNPs in RNF115 are shown (see all 912)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0521054
    ----see VAR_0521052 G R mis40--------
    rs2003556621,2
    C--145613193(+) CTCTTC/TTACCA 1 -- int10--------
    rs2014261631,2
    C--145614044(+) ATAGCA/GTTGGT 1 -- int10--------
    rs2021890331,2
    C--145614089(+) TGGGTA/GCATTT 1 -- int10--------
    rs1821373351,2
    --145614420(+) GATCTC/TGGTTC 1 -- int10--------
    rs27701761,2
    --145614432(-) ggaggA/Ttgtag 1 -- int10--------
    rs618161941,2
    C--145614468(+) TGCCTT/CGGCCT 1 -- int12Minor allele frequency- C:0.25NA 4
    rs618161951,2
    C--145614482(+) AAGTAC/GTGGGG 1 -- int14Minor allele frequency- G:0.00NA 8
    rs1868216621,2
    --145614485(+) TAGTGA/GGGACT 1 -- int10--------
    rs1916433961,2
    --145614493(+) ACTACA/GGGCAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for RNF115 (145611036 - 145690661 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for RNF115 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669179CNV Deletion23128226
    dgv15n16CNV Deletion17901297
    dgv46e201CNV Deletion23290073
    nsv818411CNV Loss17921354
    dgv33n27CNV Loss19166990
    nsv469752CNV Loss16826518
    nsv463483CNV Loss19166990
    dgv349n71CNV Loss21882294
    esv33868CNV Loss17666407
    nsv428224CNV Gain18775914

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for RNF115

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for RNF115:    About MalaCards
    alcoholism    hepatitis b    hepatitis    prostate cancer
    prostatitis    breast cancer


    RNF115 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF115
    Human Genome Epidemiology (HuGE) Navigator: RNF115 (2 documents)

    Export disorders for RNF115 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF115 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with RNF115)
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    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration. (PubMed id 18819927)1, 2 Amemiya Y....Seth A. (2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Novel RING E3 ubiquitin ligases in breast cancer. (PubMed id 16925951)1, 2 Burger A....Seth A.K. (2006)
    5. A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer. (PubMed id 16288031)1, 2 Burger A.M....Seth A.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms. (PubMed id 23242606)1 Ehsani L....Osunkoya A.O. (2013)
    8. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. (PubMed id 23418353)1 Smith C.J....McGlade C.J. (2013)
    9. Effects of partner proteins on BCA2 RING ligase activi ty. (PubMed id 22315970)1 Bacopulos S....Seth A.K. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27246 HGNC: 18154 AceView: ZNF364 Ensembl:ENSG00000121848 euGenes: HUgn27246
    ECgene: RNF115 H-InvDB: RNF115

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF115 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF115 gene:
    Search GeneIP for patents involving RNF115

    GeneCards and IP:
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