Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF115 Gene

Aliases for RNF115 Gene

  • Ring Finger Protein 115 2 3
  • Zinc Finger Protein 364 2 3 4
  • RING Finger Protein 115 4 5
  • Rabring 7 3 4
  • ZNF364 3 4
  • E3 Ubiquitin-Protein Ligase RNF115 3
  • EC 6.3.2.- 4
  • BCA2 3

External Ids for RNF115 Gene

Previous HGNC Symbols for RNF115 Gene

  • ZNF364

Previous GeneCards Identifiers for RNF115 Gene

  • GC01P144323
  • GC01P145611
  • GC01P119574

Summaries for RNF115 Gene

GeneCards Summary for RNF115 Gene

RNF115 (Ring Finger Protein 115) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is RNF126.

UniProtKB/Swiss-Prot for RNF115 Gene

  • E3 ubiquitin-protein ligase that mediates E2-dependent, Lys-48- and/or Lys-63-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

Gene Wiki entry for RNF115 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF115 Gene

Genomics for RNF115 Gene

Regulatory Elements for RNF115 Gene

Enhancers for RNF115 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RNF115 on UCSC Golden Path with GeneCards custom track

Promoters for RNF115 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF115 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF115 Gene

Chromosome:
1
Start:
145,738,868 bp from pter
End:
145,824,123 bp from pter
Size:
85,256 bases
Orientation:
Minus strand

Genomic View for RNF115 Gene

Genes around RNF115 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF115 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF115 Gene

Proteins for RNF115 Gene

  • Protein details for RNF115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4L5-RN115_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF115
    Protein Accession:
    Q9Y4L5
    Secondary Accessions:
    • A8K3Y4
    • Q5T2V9
    • Q7Z2J2

    Protein attributes for RNF115 Gene

    Size:
    304 amino acids
    Molecular mass:
    33703 Da
    Quaternary structure:
    • Interacts with RAB7A. Interacts with EGFR and FLT3.

neXtProt entry for RNF115 Gene

Post-translational modifications for RNF115 Gene

  • RING-type zinc finger-dependent and E2-dependent autoubiquitination.
  • Ubiquitination at Lys 26 and Lys 32
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF115 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RNF115 Gene

Domains & Families for RNF115 Gene

Gene Families for RNF115 Gene

Protein Domains for RNF115 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF115 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4L5

UniProtKB/Swiss-Prot:

RN115_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF115: view

Function for RNF115 Gene

Molecular function for RNF115 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates E2-dependent, Lys-48- and/or Lys-63-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

Enzyme Numbers (IUBMB) for RNF115 Gene

Gene Ontology (GO) - Molecular Function for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IEA,IPI 16925951
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity IEA,ISS --
genes like me logo Genes that share ontologies with RNF115: view
genes like me logo Genes that share phenotypes with RNF115: view

Animal Model Products

CRISPR Products

miRNA for RNF115 Gene

miRTarBase miRNAs that target RNF115

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF115 Gene

Localization for RNF115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF115 Gene

Cytoplasm, cytosol. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250 UniProtKB:Q9D0C1}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF115 Gene COMPARTMENTS Subcellular localization image for RNF115 gene
Compartment Confidence
cytosol 5
nucleus 3
endosome 2
lysosome 2
mitochondrion 2
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,TAS --
genes like me logo Genes that share ontologies with RNF115: view

Pathways & Interactions for RNF115 Gene

genes like me logo Genes that share pathways with RNF115: view

UniProtKB/Swiss-Prot Q9Y4L5-RN115_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP 23418353
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP 23418353
genes like me logo Genes that share ontologies with RNF115: view

No data available for SIGNOR curated interactions for RNF115 Gene

Drugs & Compounds for RNF115 Gene

No Compound Related Data Available

Transcripts for RNF115 Gene

mRNA/cDNA for RNF115 Gene

Unigene Clusters for RNF115 Gene

Ring finger protein 115:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF115 Gene

No ASD Table

Relevant External Links for RNF115 Gene

GeneLoc Exon Structure for
RNF115
ECgene alternative splicing isoforms for
RNF115

Expression for RNF115 Gene

mRNA expression in normal human tissues for RNF115 Gene

Protein differential expression in normal tissues from HIPED for RNF115 Gene

This gene is overexpressed in Bone (47.4), Islet of Langerhans (9.6), and CD8 Tcells (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF115 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNF115 Gene:

RNF115

SOURCE GeneReport for Unigene cluster for RNF115 Gene:

Hs.523550

mRNA Expression by UniProt/SwissProt for RNF115 Gene:

Q9Y4L5-RN115_HUMAN
Tissue specificity: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.
genes like me logo Genes that share expression patterns with RNF115: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for RNF115 Gene

Orthologs for RNF115 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF115 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF115 34
  • 91.88 (n)
  • 88.73 (a)
dog
(Canis familiaris)
Mammalia RNF115 34
  • 93.96 (n)
  • 94.08 (a)
mouse
(Mus musculus)
Mammalia Rnf115 34
  • 90.9 (n)
  • 93.09 (a)
Rnf115 16
chimpanzee
(Pan troglodytes)
Mammalia RNF115 34
  • 99.56 (n)
  • 99.01 (a)
rat
(Rattus norvegicus)
Mammalia Rnf115 34
  • 89.78 (n)
  • 93.1 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf115 34
  • 67.96 (n)
  • 75.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22142 34
zebrafish
(Danio rerio)
Actinopterygii rnf115 34
  • 65.56 (n)
  • 70.11 (a)
Dr.15141 34
Species where no ortholog for RNF115 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF115 Gene

ENSEMBL:
Gene Tree for RNF115 (if available)
TreeFam:
Gene Tree for RNF115 (if available)

Paralogs for RNF115 Gene

Paralogs for RNF115 Gene

(2) SIMAP similar genes for RNF115 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RNF115: view

Variants for RNF115 Gene

Sequence variations from dbSNP and Humsavar for RNF115 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11577731 - 145,750,494(-) TTTTA(A/G)GACAA reference, synonymous-codon, missense
rs424067 -- 145,767,379(+) CCTGT(C/T)GCCCC intron-variant
rs718942 -- 145,772,225(+) TTTTT(A/T)AAAAA intron-variant
rs1284296 -- 145,760,646(-) cccag(C/T)catgt intron-variant
rs1342125 -- 145,796,588(+) CACCA(C/T)GTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF115 Gene

Variant ID Type Subtype PubMed ID
dgv331n100 CNV gain 25217958
dgv332n100 CNV gain+loss 25217958
dgv33n27 CNV loss 19166990
dgv531n54 CNV loss 21841781
dgv532n54 CNV gain 21841781
dgv533n54 CNV gain 21841781
dgv95e212 CNV gain 25503493
esv2669179 CNV deletion 23128226
esv3572342 CNV gain 25503493
esv3587421 CNV loss 21293372
esv3587422 CNV gain 21293372
esv3587423 CNV loss 21293372
esv3894089 CNV loss 25118596
nsv1005055 CNV loss 25217958
nsv1015025 CNV gain 25217958
nsv1113171 CNV deletion 24896259
nsv1144400 CNV deletion 24896259
nsv1161499 CNV duplication 26073780
nsv463483 CNV loss 19166990
nsv463494 CNV gain 19166990
nsv469752 CNV loss 16826518
nsv470735 CNV gain 18288195
nsv547662 CNV loss 21841781
nsv547665 CNV gain+loss 21841781
nsv547670 CNV loss 21841781
nsv547671 CNV loss 21841781
nsv818411 CNV loss 17921354
nsv831381 CNV gain 17160897
nsv831392 CNV gain 17160897
nsv946266 CNV duplication 23825009
nsv950949 CNV duplication 24416366
nsv998178 CNV loss 25217958

Variation tolerance for RNF115 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF115 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF115

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF115 Gene

Disorders for RNF115 Gene

Relevant External Links for RNF115

Genetic Association Database (GAD)
RNF115
Human Genome Epidemiology (HuGE) Navigator
RNF115
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF115

No disorders were found for RNF115 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF115 Gene

Publications for RNF115 Gene

  1. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. (PMID: 23418353) Smith C.J. … McGlade C.J. (J. Cell. Sci. 2013) 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration. (PMID: 18819927) Amemiya Y. … Seth A. (Mol. Cancer Res. 2008) 3 4 65
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  5. Novel RING E3 ubiquitin ligases in breast cancer. (PMID: 16925951) Burger A. … Seth A.K. (Neoplasia 2006) 3 4 65

Products for RNF115 Gene

Sources for RNF115 Gene

Content