Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNF115 Gene

protein-coding   GIFtS: 52
GCID: GC01P145611

Ring Finger Protein 115

(Previous name: zinc finger protein 364)
(Previous symbol: ZNF364)
  Search for RNF115
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ring Finger Protein 1151 2 3     BCA22
Zinc Finger Protein 3641 2 3     E3 Ubiquitin-Protein Ligase RNF1152
ZNF3641 2 3     EC 6.3.2.-3
Rabring 72 3     

External Ids:    HGNC: 181541   Entrez Gene: 272462   Ensembl: ENSG000001218487   UniProtKB: Q9Y4L53   

Export aliases for RNF115 gene to outside databases

Previous GC identifers: GC01P144323 GC01P119574


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RNF115 Gene:
RNF115 (ring finger protein 115) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is PJA2.

UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5
Function: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking

Gene Wiki entry for RNF115 (ZNF364) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF115 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   CREB   AREB6   S8   FOXO4   deltaCREB   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF115 promoter sequence
   Search Chromatin IP Primers for RNF115

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF115


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.1   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q12

RNF115 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF115 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P145611:  view genomic region     (about GC identifiers)

Start:
145,611,036 bp from pter      End:
145,696,218 bp from pter
Size:
85,183 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RNF115  
Size: 304 amino acids; 33703 Da
Subunit: Interacts with RAB7A
Secondary accessions: A8K3Y4 Q5T2V9 Q7Z2J2

Explore the universe of human proteins at neXtProt for RNF115: NX_Q9Y4L5

Explore proteomics data for RNF115 at MOPED

Post-translational modifications: 

  • RING-type zinc finger-dependent and E2-dependent autoubiquitination1
  • Ubiquitination2 at Lys26, Lys32
  • Modification sites at PhosphoSitePlus

  • See RNF115 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055270.1  
    ENSEMBL proteins: 
     ENSP00000358297   ENSP00000444901   ENSP00000442099  

    RNF115 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RNF115
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RNF115
    GenScript Custom Purified and Recombinant Proteins Services for RNF115
    Novus Biologicals RNF115 Protein
    Novus Biologicals RNF115 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF115

     
    Search eBioscience for Proteins for RNF115 

    RNF115 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RNF115
    OriGene Custom Antibody Services for RNF115
    Novus Biologicals RNF115 Antibodies
    Abcam antibodies for RNF115
    Cloud-Clone Corp. Antibodies for RNF115
    ThermoFisher Antibodies for RNF115
    LSBio Antibodies in human, mouse, rat for RNF115

    RNF115 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNF115
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF115
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF115
    Cloud-Clone Corp. CLIAs for RNF115
    Search eBioscience for ELISAs for RNF115 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y4L5

    ProtoNet protein and cluster: Q9Y4L5

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF115           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN115_HUMAN, Q9Y4L5
    Function: Acts as an E2-dependent E3 ubiquitin-protein ligase. May be involved in endocytic trafficking

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA18819927
    GO:0005515protein binding IPI16925951
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RNF115           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF115:
     Cell cycle / mitosis defect  Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF115
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF115

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF115
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF115

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF115:
    hsa-let-7b-5p (MIRT051949), hsa-mir-484 (MIRT041801), hsa-mir-193b-3p (MIRT041372)

    Block miRNA regulation of human, mouse, rat RNF115 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate RNF115:
    hsa-miR-146a* hsa-miR-3163 hsa-miR-214 hsa-miR-513a-3p hsa-miR-3935 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRNF115 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNF115
    Predesigned siRNA for gene silencing in human, mouse, rat RNF115

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNF115

    Clone
    Products:
         
    OriGene clones in human, mouse for RNF115 (see all 6)
    OriGene ORF clones in mouse, rat for RNF115
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF115 (NM_014455)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF115
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF115

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNF115
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNF115 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF115


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RN115_HUMAN, Q9Y4L5: Cytoplasm, cytosol (By similarity). Note=The GTP-bound form of RAB7A recruits RNF115 from
    the cytosol onto late endosomes/lysosomes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    endosome1
    extracellular1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--

    Find genes that share ontologies with RNF115           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



    UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF115: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF115

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for RNF115 (Q9Y4L53 ENSP000003582974) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSSCA1O602323, ENSP000003123184I2D: score=5 STRING: ENSP00000312318
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051865protein autoubiquitination IDA16288031

    Find genes that share ontologies with RNF115           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF115 (RN115)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNF115 gene: 
    NM_014455.3  

    Unigene Cluster for RNF115:

    Ring finger protein 115
    Hs.523550  [show with all ESTs]
    Unigene Representative Sequence: NM_014455
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369291(uc001eoj.3) ENST00000539368 ENST00000542738
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF115 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate RNF115:
    hsa-miR-146a* hsa-miR-3163 hsa-miR-214 hsa-miR-513a-3p hsa-miR-3935 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidRNF115 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF115
    Predesigned siRNA for gene silencing in human, mouse, rat RNF115
    Clone
    Products:
         
    OriGene clones in human, mouse for RNF115 (see all 6)
    OriGene ORF clones in mouse, rat for RNF115
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF115 (NM_014455)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF115
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF115
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNF115
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF115
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF115
      QuantiTect SYBR Green Assays in human, mouse, rat RNF115
      QuantiFast Probe-based Assays in human, mouse, rat RNF115

    Additional mRNA sequence: 

    AF419857.1 AF542552.1 AK290749.1 AL079312.1 AL079314.1 BC054049.2 BC064903.1 

    15 DOTS entries:

    DT.100774455  DT.95339042  DT.70103706  DT.415520  DT.95168074  DT.415522  DT.100776331  DT.115477 
    DT.100792758  DT.121439318  DT.121439390  DT.91755159  DT.95168072  DT.95168076  DT.95168075 

    Selected AceView cDNA sequences (see all 127):

    BU783753 BQ225386 AI244202 BE018378 CR596995 BQ189554 BC064903 CR620298 
    BX399452 BQ431230 AL079314 AI478152 AJ709489 BF237759 BX381719 AW768287 
    AI754535 CK300403 CR597781 AA028015 AW889253 BU180855 AI004190 AI937571 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNF115    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                    -           -                                   -                           
    SP2:                    -                                               -                           
    SP3:                                -                                   -                           
    SP4:                                -           -                                                   
    SP5:                                                                                                


    ECgene alternative splicing isoforms for RNF115

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNF115 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCCTTGTA
    RNF115 Expression
    About this image

    RNF115 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF115 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523550

    UniProtKB/Swiss-Prot: RN115_HUMAN, Q9Y4L5
    Tissue specificity: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of
    expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF115: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNF115
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF115
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF115
    QuantiTect SYBR Green Assays in human, mouse, rat RNF115
    QuantiFast Probe-based Assays in human, mouse, rat RNF115
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF115

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for RNF115 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1151 , 5 ring finger protein 1151, 5 90.9(n)1
    93.09(a)1
      3 (41.96 cM)5
    678451  NM_026406.31  NP_080682.31 
     967276115 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1156
    ring finger protein 115
    78(a)
    1 ↔ 1
    GL344903.1(12512-15275)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.221422 Xenopus laevis transcribed sequence with weak similarity more 73.99(n)    BQ736630.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151412 Transcribed sequence with weak similarity to protein more 75.74(n)    AL914996.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119826
    --
    23(a)
    1 → many
    3R(4832174-4833752)
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.36
    Protein Y54E10BR.3 (Y54E10BR.3) mRNA, complete cds...
    20(a)
    1 → many
    I(3021649-3028384) WBGene00021842


    ENSEMBL Gene Tree for RNF115 (if available)
    TreeFam Gene Tree for RNF115 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNF115 gene
    PJA22  RNF1812  RNF1262  PJA12  
    2 SIMAP similar genes for RNF115 using alignment to 3 protein entries:     RN115_HUMAN (see all proteins):
    RNF126    RNF181

    Find genes that share paralogs with RNF115           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNF115 (see all 912)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2003556621,2
    C--145613193(+) CTCTTC/TTACCA 1 -- int10--------
    rs2014261631,2
    C--145614044(+) ATAGCA/GTTGGT 1 -- int10--------
    rs2021890331,2
    C--145614089(+) TGGGTA/GCATTT 1 -- int10--------
    rs1821373351,2
    --145614420(+) GATCTC/TGGTTC 1 -- int10--------
    rs27701761,2
    --145614432(-) ggaggA/Ttgtag 1 -- int10--------
    rs618161941,2
    C--145614468(+) TGCCTT/CGGCCT 1 -- int12Minor allele frequency- C:0.25NA 4
    rs618161951,2
    C--145614482(+) AAGTAC/GTGGGG 1 -- int14Minor allele frequency- G:0.00NA 8
    rs1868216621,2
    --145614485(+) TAGTGA/GGGACT 1 -- int10--------
    rs1916433961,2
    --145614493(+) ACTACA/GGGCAC 1 -- int10--------
    rs715105231,2
    C--145614519(+) GCTAAA/TTTTTG 1 -- int12Minor allele frequency- T:0.25NA 4

    HapMap Linkage Disequilibrium report for RNF115 (145611036 - 145696218 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNF115 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669179CNV Deletion23128226
    dgv15n16CNV Deletion17901297
    dgv46e201CNV Deletion23290073
    nsv818411CNV Loss17921354
    dgv33n27CNV Loss19166990
    nsv469752CNV Loss16826518
    nsv463483CNV Loss19166990
    dgv349n71CNV Loss21882294
    esv33868CNV Loss17666407
    nsv428224CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF115
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF115

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with RNF115           About GenesLikeMe

    Genetic Association Database (GAD): RNF115
    Human Genome Epidemiology (HuGE) Navigator: RNF115 (2 documents)

    Export disorders for RNF115 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNF115 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with RNF115)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration. (PubMed id 18819927)1, 2 Amemiya Y.... Seth A. (Mol. Cancer Res. 2008)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Novel RING E3 ubiquitin ligases in breast cancer. (PubMed id 16925951)1, 2 Burger A.... Seth A.K. (Neoplasia 2006)
    5. A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer. (PubMed id 16288031)1, 2 Burger A.M.... Seth A.K. (Cancer Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. (PubMed id 23962720)1 Speed D....Johnson M.R. (Hum. Mol. Genet. 2014)
    8. BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms. (PubMed id 23242606)1 Ehsani L....Osunkoya A.O. (Tumour Biol. 2013)
    9. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor. (PubMed id 23418353)1 Smith C.J....McGlade C.J. (J. Cell. Sci. 2013)
    10. Effects of partner proteins on BCA2 RING ligase activity. (PubMed id 22315970)1 Bacopulos S....Seth A.K. (BMC Cancer 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27246 HGNC: 18154 AceView: ZNF364 Ensembl:ENSG00000121848 euGenes: HUgn27246
    ECgene: RNF115 H-InvDB: RNF115

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNF115 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNF115 gene:
    Search GeneIP for patents involving RNF115

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RNF115   OriGene RNAi products in human, mouse, rat for RNF115  
     OriGene qPCR primer pairs and template standards for RNF115   OriGene Protein Over-expression Lysate for RNF115  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RNF115  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNF115   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RNF115   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF115   OriGene Custom Protein Services for RNF115  

     
     
     Block miRNA regulation of human, mouse, rat RNF115 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNF115
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF115 Predesigned siRNA for gene silencing in human, mouse, rat RNF115
     QuantiFast Probe-based Assays in human, mouse, rat RNF115 QuantiTect SYBR Green Assays in human, mouse, rat RNF115
     PCR Arrays including human, mouse, rat RNF115 Search Chromatin IP Primers for RNF115
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF115  GeneGlobe Interaction Network for RNF115
     Regulatory tfbs in RNF115 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNF115 GenScript cDNA clones with any tag delivered in your preferred vector for RNF115
     GenScript Custom Assay Services for RNF115 GenScript Custom overexpressing Cell Line Services for RNF115
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNF115 (RN115)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNF115 antibodies
     RNF115 proteins
     RNF115 lysates
     Antibodies for RNF115
     See all of Abcam's Antibodies, Kits and Proteins for RNF115
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNF115
     Antibodies for RNF115
     ELISAs for RNF115
     CLIAs for RNF115



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNF115
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF115
     SwitchGear 3'UTR luciferase reporter plasmids for RNF115
     SwitchGear Promoter luciferase reporter plasmids for RNF115
     ThermoFisher Antibodies for RNF115
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF115
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF115
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNF115
     LSBio Antibodies in human, mouse, rat for RNF115
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for RNF115
      Search eBioscience for proteins for RNF115
      Search eBioscience for elisas for RNF115
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNF115 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4