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Aliases for RNF115 Gene

Aliases for RNF115 Gene

  • Ring Finger Protein 115 2 3
  • Zinc Finger Protein 364 2 3 4
  • Rabring 7 3 4
  • ZNF364 3 4
  • E3 Ubiquitin-Protein Ligase RNF115 3
  • RING Finger Protein 115 4
  • EC 6.3.2.- 4
  • BCA2 3

External Ids for RNF115 Gene

Previous Symbols for RNF115 Gene

  • ZNF364

Summaries for RNF115 Gene

GeneCards Summary for RNF115 Gene

RNF115 (Ring Finger Protein 115) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF115 Gene

  • E3 ubiquitin-protein ligase that mediates E2-dependent, Lys-48- and/or Lys-63-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

Gene Wiki entry for RNF115 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF115 Gene

Genomics for RNF115 Gene

Genomic Location for RNF115 Gene

145,738,868 bp from pter
145,824,123 bp from pter
85,256 bases
Minus strand

Genomic View for RNF115 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF115 Gene

Regulatory Elements for RNF115 Gene

Proteins for RNF115 Gene

  • Protein details for RNF115 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF115
    Protein Accession:
    Secondary Accessions:
    • A8K3Y4
    • Q5T2V9
    • Q7Z2J2

    Protein attributes for RNF115 Gene

    304 amino acids
    Molecular mass:
    33703 Da
    Quaternary structure:
    • Interacts with RAB7A. Interacts with EGFR and FLT3.

neXtProt entry for RNF115 Gene

Proteomics data for RNF115 Gene at MOPED

Post-translational modifications for RNF115 Gene

  • RING-type zinc finger-dependent and E2-dependent autoubiquitination.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys26 and Lys32

Other Protein References for RNF115 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF115 Gene

Domains for RNF115 Gene

Gene Families for RNF115 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF115 Gene



  • Contains 1 RING-type zinc finger.:
    • Q9Y4L5
genes like me logo Genes that share domains with RNF115: view

Function for RNF115 Gene

Molecular function for RNF115 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates E2-dependent, Lys-48- and/or Lys-63-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

Enzyme Numbers (IUBMB) for RNF115 Gene

Gene Ontology (GO) - Molecular Function for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18819927
GO:0005515 protein binding IPI 16925951
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF115: view
genes like me logo Genes that share phenotypes with RNF115: view

miRNA for RNF115 Gene

miRTarBase miRNAs that target RNF115

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF115 Gene

Localization for RNF115 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF115 Gene

Cytoplasm, cytosol. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250 UniProtKB:Q9D0C1}.

Subcellular locations from

Jensen Localization Image for RNF115 Gene COMPARTMENTS Subcellular localization image for RNF115 gene
Compartment Confidence
cytosol 4
nucleus 2
endosome 1
extracellular 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with RNF115: view

Pathways for RNF115 Gene

SuperPathways for RNF115 Gene

No Data Available

UniProtKB/Swiss-Prot Q9Y4L5-RN115_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF115 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway IMP 23418353
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP 23418353
GO:0051865 protein autoubiquitination IDA 16288031
GO:0070534 protein K63-linked ubiquitination ISS --
GO:0070936 protein K48-linked ubiquitination ISS --
genes like me logo Genes that share ontologies with RNF115: view

No data available for Pathways by source for RNF115 Gene

Transcripts for RNF115 Gene

mRNA/cDNA for RNF115 Gene

Unigene Clusters for RNF115 Gene

Ring finger protein 115:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF115 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - -
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for RNF115 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF115 Gene

mRNA expression in normal human tissues for RNF115 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for RNF115 Gene

SOURCE GeneReport for Unigene cluster for RNF115 Gene Hs.523550

mRNA Expression by UniProt/SwissProt for RNF115 Gene

Tissue specificity: Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.
genes like me logo Genes that share expressions with RNF115: view

Orthologs for RNF115 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF115 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF115 36
  • 99.56 (n)
  • 99.01 (a)
(Bos Taurus)
Mammalia RNF115 36
  • 91.88 (n)
  • 88.73 (a)
(Canis familiaris)
Mammalia RNF115 36
  • 93.96 (n)
  • 94.08 (a)
(Mus musculus)
Mammalia Rnf115 36
  • 90.9 (n)
  • 93.09 (a)
Rnf115 16
(Rattus norvegicus)
Mammalia Rnf115 36
  • 89.78 (n)
  • 93.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22142 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf115 36
  • 67.96 (n)
  • 75.7 (a)
(Danio rerio)
Actinopterygii Dr.15141 36
rnf115 36
  • 65.56 (n)
  • 70.11 (a)
Species with no ortholog for RNF115:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF115 Gene

Gene Tree for RNF115 (if available)
Gene Tree for RNF115 (if available)

Paralogs for RNF115 Gene

Selected SIMAP similar genes for RNF115 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RNF115: view

No data available for Paralogs for RNF115 Gene

Variants for RNF115 Gene

Sequence variations from dbSNP and Humsavar for RNF115 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs424067 -- 145,767,379(-) CCTGT(C/T)GCCCC intron-variant
rs718942 -- 145,772,225(-) TTTTT(A/T)AAAAA intron-variant
rs1284296 -- 145,760,646(+) cccag(C/T)catgt intron-variant
rs1297551 -- 145,762,215(+) ctaaa(C/T)gaatt intron-variant
rs1297552 -- 145,763,876(-) AAAAA(A/T)TATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF115 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
nsv831381 CNV Gain 17160897
esv529 CNV CNV 17122850
dgv33n27 CNV Loss 19166990
dgv349n71 CNV Loss 21882294
dgv350n71 CNV Gain 21882294
nsv428224 CNV Gain 18775914
dgv351n71 CNV Gain 21882294
nsv872241 CNV Gain+Loss 21882294
nsv831392 CNV Gain 17160897
nsv470735 CNV Gain 18288195
nsv818411 CNV Loss 17921354
esv33868 CNV Loss 17666407
essv3464 CNV CNV 17122850
nsv469752 CNV Loss 16826518
nsv463483 CNV Loss 19166990
nsv463494 CNV Gain 19166990
esv2669179 CNV Deletion 23128226
dgv352n71 CNV Gain 21882294

Relevant External Links for RNF115 Gene

HapMap Linkage Disequilibrium report

Disorders for RNF115 Gene

Relevant External Links for RNF115

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RNF115: view

No data available for UniProtKB/Swiss-Prot for RNF115 Gene

Publications for RNF115 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A novel RING-type ubiquitin ligase breast cancer-associated gene 2 correlates with outcome in invasive breast cancer. (PMID: 16288031) Burger A.M. … Seth A.K. (Cancer Res. 2005) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Novel RING E3 ubiquitin ligases in breast cancer. (PMID: 16925951) Burger A. … Seth A.K. (Neoplasia 2006) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for RNF115 Gene

Sources for RNF115 Gene

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