Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF114 Gene

Aliases for RNF114 Gene

  • Ring Finger Protein 114 2 3
  • Zinc Finger Protein 313 2 3 4
  • ZNF313 3 4 6
  • Zinc Finger Protein 228 3 4
  • E3 Ubiquitin-Protein Ligase RNF114 3
  • RING Finger Protein 114 4
  • EC 6.3.2.- 4
  • PSORS12 3
  • ZNF228 4

External Ids for RNF114 Gene

Previous Symbols for RNF114 Gene

  • ZNF313

Summaries for RNF114 Gene

GeneCards Summary for RNF114 Gene

RNF114 (Ring Finger Protein 114) is a Protein Coding gene. An important paralog of this gene is RNF166.

UniProtKB/Swiss-Prot for RNF114 Gene

  • E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycles G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF114 Gene

Genomics for RNF114 Gene

Genomic Location for RNF114 Gene

49,936,336 bp from pter
49,953,892 bp from pter
17,557 bases
Plus strand

Genomic View for RNF114 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF114 Gene

Regulatory Elements for RNF114 Gene

Proteins for RNF114 Gene

  • Protein details for RNF114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF114
    Protein Accession:
    Secondary Accessions:
    • B2RDQ9
    • B4DWY5
    • E1P627
    • Q6N0B0

    Protein attributes for RNF114 Gene

    228 amino acids
    Molecular mass:
    25694 Da
    Quaternary structure:
    • Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
    • Sequence=CAE45709.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF114 Gene


neXtProt entry for RNF114 Gene

Proteomics data for RNF114 Gene at MOPED

Post-translational modifications for RNF114 Gene

  • Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys38, Lys61, Lys96, Lys102, Lys112, Lys122, Lys126, Lys149, Lys161, and Lys169

Other Protein References for RNF114 Gene

No data available for DME Specific Peptides for RNF114 Gene

Domains for RNF114 Gene

Gene Families for RNF114 Gene

  • RNF :RING-type (C3HC4) zinc fingers


  • Contains 1 RING-type zinc finger.:
    • Q9Y508
genes like me logo Genes that share domains with RNF114: view

Function for RNF114 Gene

Molecular function for RNF114 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycles G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.

Enzyme Numbers (IUBMB) for RNF114 Gene

Gene Ontology (GO) - Molecular Function for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF114: view

miRNA for RNF114 Gene

miRTarBase miRNAs that target RNF114

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF114 Gene

Localization for RNF114 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF114 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for RNF114 Gene COMPARTMENTS Subcellular localization image for RNF114 gene
Compartment Confidence
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RNF114: view

Pathways for RNF114 Gene

SuperPathways for RNF114 Gene

No Data Available

UniProtKB/Swiss-Prot Q9Y508-RN114_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RNF114: view

No data available for Pathways by source for RNF114 Gene

Transcripts for RNF114 Gene

Unigene Clusters for RNF114 Gene

Ring finger protein 114:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF114 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: -

Relevant External Links for RNF114 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF114 Gene

mRNA expression in normal human tissues for RNF114 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNF114 Gene

SOURCE GeneReport for Unigene cluster for RNF114 Gene Hs.144949

mRNA Expression by UniProt/SwissProt for RNF114 Gene

Tissue specificity: Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis.
genes like me logo Genes that share expressions with RNF114: view

Orthologs for RNF114 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF114 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF114 36
  • 99.56 (n)
  • 99.56 (a)
RNF114 37
  • 100 (a)
(Bos Taurus)
Mammalia RNF114 36
  • 90.12 (n)
  • 95.13 (a)
RNF114 37
  • 93 (a)
(Canis familiaris)
Mammalia RNF114 36
  • 92.25 (n)
  • 94.3 (a)
RNF114 37
  • 94 (a)
(Mus musculus)
Mammalia Rnf114 36
  • 88.11 (n)
  • 89.87 (a)
Rnf114 16
Rnf114 37
  • 90 (a)
(Monodelphis domestica)
Mammalia RNF114 37
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia RNF114 37
  • 77 (a)
(Rattus norvegicus)
Mammalia Rnf114 36
  • 87.37 (n)
  • 88.99 (a)
(Gallus gallus)
Aves RNF114 36
  • 72.58 (n)
  • 72.27 (a)
RNF114 37
  • 71 (a)
(Anolis carolinensis)
Reptilia RNF114 37
  • 68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16622 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf114 36
  • 63.03 (n)
  • 56.82 (a)
Str.15724 36
(Danio rerio)
Actinopterygii rnf114 36
  • 57.88 (n)
  • 53.23 (a)
rnf114 37
  • 51 (a)
Species with no ortholog for RNF114:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF114 Gene

Gene Tree for RNF114 (if available)
Gene Tree for RNF114 (if available)

Paralogs for RNF114 Gene

Paralogs for RNF114 Gene

Selected SIMAP similar genes for RNF114 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNF114: view

Variants for RNF114 Gene

Sequence variations from dbSNP and Humsavar for RNF114 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs12710 -- 49,953,701(-) GTTTC(A/G)CCAGA utr-variant-3-prime
rs1006682 -- 49,954,076(-) CTGTA(A/G)CAAGT downstream-variant-500B
rs1056198 -- 49,939,692(+) CCTCA(C/T)AATCC intron-variant
rs1056200 -- 49,939,711(+) TAGCC(A/G)TCTGT intron-variant
rs1107411 -- 49,948,392(+) TCTGG(C/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF114 Gene

Variant ID Type Subtype PubMed ID
nsv912915 CNV Loss 21882294

Relevant External Links for RNF114 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for RNF114 Gene

(2) University of Copenhagen DISEASES for RNF114 Gene

Relevant External Links for RNF114

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RNF114: view

No data available for UniProtKB/Swiss-Prot for RNF114 Gene

Publications for RNF114 Gene

  1. Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. (PMID: 18364390) Capon F. … Trembath R.C. (Hum. Mol. Genet. 2008) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Identification of a novel human zinc finger protein gene ZNF313. (PMID: 12621547) Ma Y.-X. … Sun Y. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RNF114 Gene

Sources for RNF114 Gene

Back to Top