Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF114 Gene

protein-coding   GIFtS: 52
GCID: GC20P048552

Ring Finger Protein 114

(Previous name: zinc finger protein 313)
(Previous symbol: ZNF313)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1141 2
ZNF3131 2 3 5
Zinc Finger Protein 3131 2 3
Zinc Finger Protein 2282 3
PSORS122
ZNF2283

External Ids:    HGNC: 130941   Entrez Gene: 559052   Ensembl: ENSG000001242267   OMIM: 6124515   UniProtKB: Q9Y5083   

Export aliases for RNF114 gene to outside databases

Previous GC identifers: GC20P047987 GC20P045301


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF114 Gene: 
RNF114 (ring finger protein 114) is a protein-coding gene. Diseases associated with RNF114 include psoriatic arthritis, and psoriasis. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is RNF125.

UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508
Function: May play a role in spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF114 gene promoter:
         GR   AML1a   ATF-2   CREB   N-Myc   AREB6   deltaCREB   GR-alpha   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF114 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF114

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF114


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.13   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13

RNF114 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF114 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P048552:  view genomic region     (about GC identifiers)

Start:
48,552,914 bp from pter      End:
48,570,429 bp from pter
Size:
17,516 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508 (See protein sequence)
Recommended Name: RING finger protein 114  
Size: 228 amino acids; 25694 Da
Sequence caution: Sequence=CAE45709.1; Type=Erroneous initiation;
Secondary accessions: B2RDQ9 B4DWY5 E1P627 Q6N0B0
Alternative splicing: 2 isoforms:  Q9Y508-1   Q9Y508-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF114: NX_Q9Y508

Explore proteomics data for RNF114 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y508

  • RNF114 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF114 Protein Expression
    REFSEQ proteins: NP_061153.1  
    ENSEMBL proteins: 
     ENSP00000244061  

    Human Recombinant Protein Products for RNF114: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RNF114
    OriGene Protein Over-expression Lysate for RNF114
    OriGene MassSpec for RNF114 
    OriGene Custom Protein Services for RNF114
    GenScript Custom Purified and Recombinant Proteins Services for RNF114
    Novus Biologicals RNF114 Protein
    Novus Biologicals RNF114 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNF114 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--

    RNF114 for ontologies           About GeneDecksing



    RNF114 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RNF114
    OriGene Custom Antibody Services for RNF114
    GenScript Custom Superior Antibodies Services for RNF114
    Novus Biologicals RNF114 Antibodies
    Abcam antibodies for RNF114
    Cloud-Clone Corp. Antibodies for RNF114 
    ThermoFisher Antibodies for RNF114
    LSBio Antibodies in human, mouse, rat for RNF114 

    Assay Products for RNF114: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNF114
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNF114
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNF114 
    Cloud-Clone Corp. CLIAs for RNF114


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR008598 Di19_RING_finger_144
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y508

    ProtoNet protein and cluster: Q9Y508

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508
    Similarity: Contains 1 RING-type zinc finger


    RNF114 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN114_HUMAN, Q9Y508
    Function: May play a role in spermatogenesis

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF114 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF114 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF114

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF114 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF114 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF114
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF114 (see all 24):
    hsa-miR-875-3p hsa-miR-4286 hsa-miR-300 hsa-miR-767-5p hsa-miR-519a hsa-miR-218 hsa-miR-374c hsa-miR-499-5p
    SwitchGear 3'UTR luciferase reporter plasmidRNF114 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNF114
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF114

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNF114
    Sirion Biotech Customized adenovirus for overexpression of RNF114

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RNF114 (see all 7)
    OriGene ORF clones in mouse, rat for RNF114
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF114 (NM_018683)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF114
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF114
    Sirion Biotech Customized lentivirus for stable overexpression of RNF114 
                         Customized lentivirus expression plasmids for stable overexpression of RNF114 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNF114
    Search LifeMap BioReagents cell lines for RNF114
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF114


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF114

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/31 Interacting proteins for RNF114 (Q9Y5082, 3 ENSP000002440614) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273612, 3, ENSP000002630254MINT-8260592 I2D: score=2 STRING: ENSP00000263025
    PARP11Q9NR213, ENSP000002288204I2D: score=2 STRING: ENSP00000228820
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    RNF114 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF114 (RN114)

    Search CenterWatch for drugs/clinical trials and news about RNF114 / RN114

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF114 gene: 
    NM_018683.3  

    Unigene Cluster for RNF114:

    Ring finger protein 114
    Hs.144949  [show with all ESTs]
    Unigene Representative Sequence: NM_018683
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244061(uc002xux.3 uc002xuy.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNF114
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF114 (see all 24):
    hsa-miR-875-3p hsa-miR-4286 hsa-miR-300 hsa-miR-767-5p hsa-miR-519a hsa-miR-218 hsa-miR-374c hsa-miR-499-5p
    SwitchGear 3'UTR luciferase reporter plasmidRNF114 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNF114
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF114
    Clone
    Products:
         
    OriGene clones in human, mouse for RNF114 (see all 7)
    OriGene ORF clones in mouse, rat for RNF114
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF114 (NM_018683)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF114
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF114
    Sirion Biotech Customized lentivirus for stable overexpression of RNF114 
                         Customized lentivirus expression plasmids for stable overexpression of RNF114 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNF114
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF114
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF114
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF114
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF114

    Additional mRNA sequence: 

    AF131742.1 AF265215.1 AK091976.1 AK297188.1 AK301731.1 AK315638.1 BC013695.1 BC066919.1 
    BT006795.1 BX640603.1 

    14 DOTS entries:

    DT.456240  DT.100652966  DT.100652963  DT.120823875  DT.423580  DT.102829176  DT.102829177  DT.100717554 
    DT.91758106  DT.100652961  DT.100742559  DT.91758115  DT.97788701  DT.101986637 

    24/593 AceView cDNA sequences (see all 593):

    BM700380 BU538163 BQ229049 AW058332 AA460912 AI125569 BU618214 AI801687 
    BM744213 BE855553 BX110198 BQ223870 AI276380 CD358157 CB055030 BM718184 
    AU279953 BM824064 AA700603 AW050688 BM726143 AA781666 AI630222 BG056104 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RNF114 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
    SP1:                    -           -     -                 -                                       
    SP2:                                -     -                 -                                       
    SP3:                    -     -     -     -                 -                                       
    SP4:                                                        -                                       
    SP5:                                                                                                


    ECgene alternative splicing isoforms for RNF114

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF114 expression in normal human tissues (normalized intensities)      RNF114 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACAGAGCT
    RNF114 Expression
    About this image


    RNF114 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             bone marrow cd34+   
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             oocyte   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   
     
     Gonad
             XY Germ Cells Testis Cord

    See RNF114 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF114

    SOURCE GeneReport for Unigene cluster: Hs.144949

    UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508
    Tissue specificity: Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest
    levels in testis

        SABiosciences Expression via Pathway-Focused PCR Array including RNF114: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNF114
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF114
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF114
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF114
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF114
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF114

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNF114 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1141 , 5 ring finger protein 1141, 5 88.11(n)1
    89.87(a)1
      2 (87.25 cM)5
    810181  NM_030743.51  NP_109668.21 
     1674926455 
    chicken
    (Gallus gallus)
    Aves RNF1141 ring finger protein 114 72.58(n)
    72.27(a)
      414881  NM_001001767.2  NP_001001767.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1146
    Uncharacterized protein
    68(a)
    1 ↔ 1
    4(147392228-147401271)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.166222 Xenopus laevis transcribed sequence with weak similarity more 75.13(n)    BJ035216.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf1141 ring finger protein 114 57.88(n)
    53.23(a)
      414843  NM_001001828.4  NP_001001828.2 


    ENSEMBL Gene Tree for RNF114 (if available)
    TreeFam Gene Tree for RNF114 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF114 gene
    RNF1252  RNF1662  RNF1382  
    3 SIMAP similar genes for RNF114 using alignment to 1 protein entry:     RN114_HUMAN:
    ZNF313    RNF166    RNF125

    RNF114 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/492 SNPs in RNF114 are shown (see all 492)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829327861,2
    C--45299383(+) AATCAA/TTATGG 1 -- us2k10--------
    rs736254471,2
    C--48550925(+) GGGTT-/AAAAAA 1 -- us2k10--------
    rs116978271,2
    H--48551057(+) acaggA/Ccaggc 1 -- us2k10--------
    rs1461856901,2
    --48551094(+) CATTTC/TGGGAG 1 -- us2k10--------
    rs1886431091,2
    --48551127(+) AGGTCA/GGGCGT 1 -- us2k10--------
    rs1393757361,2
    C--48551198(+) CAGGCA/GTGGTG 1 -- us2k10--------
    rs1926474551,2
    C--48551315(+) CTGGGA/C/TGACAG 1 -- us2k10--------
    rs1499633211,2
    C--48551580(+) AAGACC/TAGAAT 1 -- us2k10--------
    rs731292641,2
    C,F--48551679(+) TTGTTG/TTTTTT 1 -- us2k15Minor allele frequency- T:0.40WA NA EA 128
    rs2009067791,2
    C--48551886(+) TTGTGG/TTTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF114 (48552914 - 48570429 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF114:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912915CNV Loss21882294


    Human Gene Mutation Database (HGMD): RNF114
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF114
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF114

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612451    OMIM disorders: --

    4 diseases for RNF114:    About MalaCards
    psoriatic arthritis    psoriasis    arthritis    gastric cancer

    2 diseases from the University of Copenhagen DISEASES database for RNF114:
    Psoriasis     Psoriatic arthritis

    RNF114 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF114
    Human Genome Epidemiology (HuGE) Navigator: RNF114 (3 documents)

    Export disorders for RNF114 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF114 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with RNF114)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. (PubMed id 18364390)1, 2, 3 Capon F.... Trembath R.C. (2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of a novel human zinc finger protein gene ZNF313. (PubMed id 12621547)1, 2 Ma Y.-X.... Sun Y. (2003)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. ZNF313 is a novel cell cycle activator with an E3 liga se activity inhibiting cellular senescence by destabilizing p21(WAF1.). (PubMed id 23645206)1 Han J....Chi S.G. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55905 HGNC: 13094 AceView: ZNF313 Ensembl:ENSG00000124226 euGenes: HUgn55905
    ECgene: RNF114 H-InvDB: RNF114

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF114 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF114 gene:
    Search GeneIP for patents involving RNF114

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RNF114   OriGene RNAi products in human, mouse, rat for RNF114  
     OriGene qPCR primer pairs and template standards for RNF114   OriGene Protein Over-expression Lysate for RNF114  
     OriGene MassSpec something-or-other for RNF114   OriGene clones in human, mouse for RNF114  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNF114   OriGene Purified Protein for RNF114  
     OriGene ORF clones in mouse, rat for RNF114   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNF114   OriGene Custom Protein Services for RNF114  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF114
     QIAGEN SeqTarget long-range PCR primers for resequencing RNF114
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF114
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF114
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF114
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF114
     GenScript Custom Purified and Recombinant Proteins Services for RNF114 GenScript cDNA clones with any tag delivered in your preferred vector for RNF114
     GenScript Custom Assay Services for RNF114 GenScript Custom Superior Antibodies Services for RNF114
     GenScript Custom overexpressing Cell Line Services for RNF114 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RNF114 promoter
     Search Chromatin IP Primers for RNF114
     RT2 qPCR Primer Assay in human, mouse, rat RNF114
     Search GNC Networks for RNF114
     SABiosciences PCR Arrays including human, mouse, rat RNF114
     Search Tocris compounds for RNF114 (RN114)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RNF114 antibodies
     RNF114 proteins
     RNF114 lysates
     Antibodies for RNF114
     See all of Abcam's Antibodies, Kits and Proteins for RNF114
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for RNF114
     Antibodies for RNF114
     ELISAs for RNF114
     CLIAs for RNF114
     Search LifeMap BioReagents cell lines for RNF114
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF114
     SwitchGear 3'UTR luciferase reporter plasmids for RNF114
     SwitchGear Promoter luciferase reporter plasmids for RNF114
     ThermoFisher Antibodies for RNF114
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF114
     inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF114
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF114
    Customized:
     lentivirus for stable overexpression of RNF114
     lentivirus expression plasmids for stable overexpression of RNF114
     adenovirus for overexpression of RNF114
     LSBio Antibodies in human, mouse, rat for RNF114
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNF114 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4