RNF114 Gene
protein-coding GIFtS: 50
GCID: GC20P048552
|
|
ring finger protein 114(Previous name: zinc finger protein 313 )
(Previous symbol: ZNF313)
| |
Aliases
for RNF114 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1141 2 | | ZNF3131 2 3 5 | | Zinc Finger Protein 3131 2 3 | | PSORS121 2 | | Zinc Finger Protein 2282 3 | | ZNF2283 |
Export aliases for RNF114 gene to outside databasesPrevious GC identifers: GC20P047987 GC20P045301 |
Summaries
for RNF114 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508Function: May play a role in spermatogenesis
|
Genomic Views
for RNF114 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNF114 gene promoter:
GR AML1a ATF-2 CREB N-Myc AREB6 deltaCREB GR-alpha Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF114
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF114 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.13 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13RNF114 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P048552: view genomic region
(about GC identifiers)
Start:
|
48,552,914 bp from pter |
End:
|
48,570,429 bp from pter |
Size:
|
17,516 bases |
Orientation:
|
plus strand |
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Proteins
for RNF114 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508 (See
protein sequence)Recommended Name: RING finger protein 114 Size: 228 amino acids; 25694 Da
Sequence caution: Sequence=CAE45709.1; Type=Erroneous initiation;
Secondary accessions: B2RDQ9 B4DWY5 E1P627 Q6N0B0Alternative splicing: 2 isoforms: Q9Y508-1 Q9Y508-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RNF114: NX_Q9Y508
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y508
RNF114 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061153.1
ENSEMBL proteins: ENSP00000244061
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IDA | -- |
RNF114 for ontologies About GeneDecksing
RNF114 Antibody Products:
Assay Products for RNF114: |
Protein
Domains /
Families
for RNF114 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF114 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y508ProtoNet protein and cluster: Q9Y508 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508Similarity: Contains 1 RING-type zinc finger |
Function
for RNF114 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508Function: May play a role in spermatogenesis
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF114 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF114
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for RNF114 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF114 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF114 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
RNF114 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNF114 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF114
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for RNF114 (Q9Y5082, 3 ENSP000002440614) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007283 | spermatogenesis |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- |
RNF114 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNF114 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNF114
Search CenterWatch for drugs/clinical trials and news about RNF114 / RN114
|
Transcripts
for RNF114 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNF114 gene: NM_018683.3 Unigene Cluster for RNF114: Ring finger protein 114 Hs.144949 [show with all ESTs]Unigene Representative Sequence: NM_0186831 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000244061(uc002xux.3 uc002xuy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF114 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF114
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNF114 (NM_018683) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF114 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF114 |
Additional cDNA sequence: AF131742.1 AF265215.1 AK091976.1 AK297188.1 AK301731.1 AK315638.1 BC013695.1 BC066919.1 BT006795.1 BX640603.1 14 DOTS entries: DT.456240 DT.100652966 DT.100652963 DT.120823875 DT.423580 DT.102829176 DT.102829177 DT.100717554 DT.91758106 DT.100652961 DT.100742559 DT.91758115 DT.97788701 DT.101986637 24/593 AceView cDNA sequences (see all 593): BU633772 AI202524 F09973 CR626179 AI183865 BU538163 CD358157 Z33441 BM477922 BM841439 AA887061 BE328665 BM718184 AA700603 CA865521 AI582202 AV648737 AL583254 BM687413 AU279953 AI630222 AI139035 AI493778 AA827388
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RNF114 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e |
|---|
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| SP1: | | | | | | | - | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RNF114
|
Expression
for RNF114 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF114 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACAGAGCT
About this image
See RNF114 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF114
SOURCE GeneReport for Unigene cluster: Hs.144949
UniProtKB/Swiss-Prot: RN114_HUMAN, Q9Y508Tissue specificity: Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levelsin testis
SABiosciences Expression via Pathway-Focused PCR Array including RNF114:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF114
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF114 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF114 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF114 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF114 |
Orthologs
for RNF114 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNF114 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for RNF114 (if available)
TreeFam Gene Tree for RNF114 (if available) |
Paralogs
for RNF114 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNF114 gene
- RNF1252 RNF1662 RNF1382
3 SIMAP similar genes for RNF114 using alignment to 1 protein entry: RN114_HUMAN:ZNF313 RNF166 RNF125
RNF114 for paralogs About GeneDecksing
|
Genomic Variants
for RNF114 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNF114 (48552914 - 48570429 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNF114: --
Human Gene Mutation Database (HGMD): RNF114
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF114 |
|
Disorders
/ Diseases
for RNF114 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF114 for disorders About GeneDecksing
OMIM gene information: 612451
OMIM disorders: --
3  diseases for RNF114: About MalaCardspsoriatic arthritis psoriasis arthritis
1 disease from the University of Copenhagen DISEASES database for RNF114:Psoriasis Human Genome Epidemiology (HuGE) Navigator: RNF114 (3 documents)
Export disorders for RNF114 gene to outside databases
|
Publications
for RNF114 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF114 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with RNF114) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. (PubMed id 18364390)1, 2, 3 Capon F.... Trembath R.C. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a novel human zinc finger protein gene ZNF313. (PubMed id 12621547)1, 2 Ma Y.-X.... Sun Y. (2003)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Identification of rare, disease-associated variants in the promoter region of the RNF114 psoriasis susceptibility gene. (PubMed id 22205304)1 Onoufriadis A....Capon F. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for RNF114 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNF114 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF114 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF114 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNF114 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF114 gene:
Search GeneIP for patents involving RNF114
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNF114 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for RNF114 | | OriGene shRNA RFP for RNF114 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNF114 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF114 | | | OriGene Protein Over-expression Lysate for RNF114 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for RNF114 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF114 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF114 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RNF114 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNF114 | | OriGene Custom Protein Services for RNF114 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNF114 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNF114 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF114 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNF114 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF114 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF114 |
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 | | | RNF114 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF114 |
|  |  |  | | | | ThermoFisher Antibodies for RNF114 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF114 |
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