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Aliases for RNF114 Gene

Aliases for RNF114 Gene

  • Ring Finger Protein 114 2 3
  • Zinc Finger Protein 313 2 3 4
  • RING-Type E3 Ubiquitin Transferase RNF114 3 4
  • Zinc Finger Protein 228 3 4
  • RING Finger Protein 114 4 5
  • ZNF313 3 4
  • E3 Ubiquitin-Protein Ligase RNF114 3
  • EC 4
  • PSORS12 3
  • ZNF228 4

External Ids for RNF114 Gene

Previous HGNC Symbols for RNF114 Gene

  • ZNF313

Previous GeneCards Identifiers for RNF114 Gene

  • GC20P047987
  • GC20P048552
  • GC20P045301

Summaries for RNF114 Gene

GeneCards Summary for RNF114 Gene

RNF114 (Ring Finger Protein 114) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity. An important paralog of this gene is RNF166.

UniProtKB/Swiss-Prot for RNF114 Gene

  • E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycles G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF114 Gene

Genomics for RNF114 Gene

Regulatory Elements for RNF114 Gene

Enhancers for RNF114 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G049671 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 16 -259.2 -259194 11.7 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A DMAP1 SLC9A8 B4GALT5 RNF114 ZNFX1 RNU6-919P ENSG00000232043 SNAI1 LINC01273 ARFGEF2 TMEM189
GH20G049886 1.5 Ensembl ENCODE dbSUPER 20.3 -45.8 -45840 8.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B GLIS2 ELK1 SPATA2 RNF114 SLC9A8 ENSG00000199490 RNU6-919P ENSG00000232043 PIR47638 GC20P049892 PIR31554
GH20G049810 1.4 ENCODE dbSUPER 19.7 -123.3 -123308 4.5 HDGF PKNOX1 FOXA2 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B RNF114 SPATA2 ENSG00000232043 ARFGEF2 SLC9A8 RNU7-72P
GH20G050046 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +112.5 112460 5.5 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF48 ZBTB7B ZNF121 SLC30A9 GATA2 SNAI1 SLC9A8 LINC01273 RNF114 CEBPB PTPN1 B4GALT5 TMEM189 LOC105372655 TRERNA1
GH20G050218 2 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +287.1 287065 9.2 HDGF PKNOX1 ZFP64 SIN3A YBX1 ZBTB7B YY1 ZNF143 ZNF207 FOS CEBPB SLC9A8 SNAI1 LINC01273 PTPN1 RNF114 ENSG00000232043 MIR645 LINC01270 TMEM189
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF114 on UCSC Golden Path with GeneCards custom track

Promoters for RNF114 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RNF114 Gene

49,936,336 bp from pter
49,953,892 bp from pter
17,557 bases
Plus strand

Genomic View for RNF114 Gene

Genes around RNF114 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF114 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF114 Gene

Proteins for RNF114 Gene

  • Protein details for RNF114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF114
    Protein Accession:
    Secondary Accessions:
    • B2RDQ9
    • B4DWY5
    • E1P627
    • Q6N0B0

    Protein attributes for RNF114 Gene

    228 amino acids
    Molecular mass:
    25694 Da
    Quaternary structure:
    • Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
    • Sequence=CAE45709.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF114 Gene


neXtProt entry for RNF114 Gene

Post-translational modifications for RNF114 Gene

  • Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1.
  • Ubiquitination at isoforms=238, Lys61, Lys96, isoforms=2102, Lys122, Lys126, isoforms=2149, isoforms=2161, and isoforms=169
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF114 Gene

No data available for DME Specific Peptides for RNF114 Gene

Domains & Families for RNF114 Gene

Gene Families for RNF114 Gene

Suggested Antigen Peptide Sequences for RNF114 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF114: view

No data available for UniProtKB/Swiss-Prot for RNF114 Gene

Function for RNF114 Gene

Molecular function for RNF114 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycles G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.

Enzyme Numbers (IUBMB) for RNF114 Gene

Gene Ontology (GO) - Molecular Function for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF114: view
genes like me logo Genes that share phenotypes with RNF114: view

Animal Model Products

CRISPR Products

miRNA for RNF114 Gene

miRTarBase miRNAs that target RNF114

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF114 Gene

Localization for RNF114 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF114 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF114 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA,TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with RNF114: view

Pathways & Interactions for RNF114 Gene

genes like me logo Genes that share pathways with RNF114: view

UniProtKB/Swiss-Prot Q9Y508-RN114_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RNF114: view

No data available for SIGNOR curated interactions for RNF114 Gene

Drugs & Compounds for RNF114 Gene

No Compound Related Data Available

Transcripts for RNF114 Gene

Unigene Clusters for RNF114 Gene

Ring finger protein 114:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF114 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: -

Relevant External Links for RNF114 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF114 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF114 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF114 Gene

This gene is overexpressed in Testis (12.5), Peripheral blood mononuclear cells (9.2), and Breast (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF114 Gene

Protein tissue co-expression partners for RNF114 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF114 Gene:


SOURCE GeneReport for Unigene cluster for RNF114 Gene:


mRNA Expression by UniProt/SwissProt for RNF114 Gene:

Tissue specificity: Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis.

Evidence on tissue expression from TISSUES for RNF114 Gene

  • Nervous system(4.9)
  • Lung(3.1)
  • Intestine(2.9)
  • Skin(2.6)
  • Eye(2.2)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with RNF114: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF114 Gene

Orthologs for RNF114 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF114 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF114 34 35
  • 99.56 (n)
(Canis familiaris)
Mammalia RNF114 34 35
  • 92.25 (n)
(Bos Taurus)
Mammalia RNF114 34 35
  • 90.12 (n)
(Mus musculus)
Mammalia Rnf114 34 16 35
  • 88.11 (n)
(Rattus norvegicus)
Mammalia Rnf114 34
  • 87.37 (n)
(Ornithorhynchus anatinus)
Mammalia RNF114 35
  • 77 (a)
(Monodelphis domestica)
Mammalia RNF114 35
  • 76 (a)
(Gallus gallus)
Aves RNF114 34 35
  • 72.58 (n)
(Anolis carolinensis)
Reptilia RNF114 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf114 34
  • 63.03 (n)
Str.15724 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16622 34
(Danio rerio)
Actinopterygii rnf114 34 35
  • 57.88 (n)
Species where no ortholog for RNF114 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF114 Gene

Gene Tree for RNF114 (if available)
Gene Tree for RNF114 (if available)

Paralogs for RNF114 Gene

Paralogs for RNF114 Gene

(3) SIMAP similar genes for RNF114 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNF114: view

Variants for RNF114 Gene

Sequence variations from dbSNP and Humsavar for RNF114 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000052460 -- 49,950,047(+) GGGTT(C/T)GAGAC intron-variant
rs1000076915 -- 49,939,153(+) TCTAT(C/G)ATCAC intron-variant
rs1000088092 -- 49,941,108(+) GTAGC(A/G)CTTTG intron-variant
rs1000256355 -- 49,938,467(+) ACCTT(C/T)TGTGC intron-variant
rs1000338503 -- 49,950,389(+) TTGGT(G/T)TGGGG intron-variant

Variation tolerance for RNF114 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF114 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RNF114 Gene

Disorders for RNF114 Gene

Relevant External Links for RNF114

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF114 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF114 Gene

Publications for RNF114 Gene

  1. Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. (PMID: 18364390) Capon F. … Trembath R.C. (Hum. Mol. Genet. 2008) 2 3 4 64
  2. ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). (PMID: 23645206) Han J. … Chi S.G. (Cell Death Differ. 2013) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of a novel human zinc finger protein gene ZNF313. (PMID: 12621547) Ma Y.-X. … Sun Y. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2003) 3 4 64

Products for RNF114 Gene

Sources for RNF114 Gene

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