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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF113B Gene

protein-coding   GIFtS: 43
GCID: GC13M098828

Ring Finger Protein 113B

(Previous name: zinc finger protein 183-like 1)
(Previous symbol: ZNF183L1)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 113B1 2
Zinc Finger Protein 183-Like 11 2 3
ZNF183L11 2 3
RNF1612 3
bA10G5.12

External Ids:    HGNC: 172671   Entrez Gene: 1404322   Ensembl: ENSG000001397977   UniProtKB: Q8IZP63   

Export aliases for RNF113B gene to outside databases

Previous GC identifers: GC00U921548 GC13M097627 GC13M079425


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNF113B Gene: 
RNF113B (ring finger protein 113B) is a protein-coding gene. Diseases associated with RNF113B include keratoconus. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is RNF113A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF113B gene promoter:
         USF1   USF2   CUTL1   USF-1:USF-2   NRSF form 2   Ik-2   POU2F1   POU2F1a   USF-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF113B promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF113B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF113B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.2   Ensembl cytogenetic band:  13q32.2   HGNC cytogenetic band: 13q32.2

RNF113B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF113B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M098828:  view genomic region     (about GC identifiers)

Start:
98,828,039 bp from pter      End:
98,829,521 bp from pter
Size:
1,483 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: R113B_HUMAN, Q8IZP6 (See protein sequence)
Recommended Name: RING finger protein 113B  
Size: 322 amino acids; 36259 Da
1 PDB 3D structure from and Proteopedia for RNF113B:
2CSY (3D)    
Secondary accessions: Q8WWF9 Q96QY9

Explore the universe of human proteins at neXtProt for RNF113B: NX_Q8IZP6

Explore proteomics data for RNF113B at MOPED 

RNF113B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RNF113B Protein Expression

REFSEQ proteins: NP_849192.1  
ENSEMBL proteins: 
 ENSP00000267291  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNF: RING-type (C3HC4) zinc fingers

4 InterPro protein domains:
 IPR000571 Znf_CCCH
 IPR017907 Znf_RING_CS
 IPR001841 Znf_RING
 IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q8IZP6

ProtoNet protein and cluster: Q8IZP6

2 Blocks protein domains:
IPB000571 Zn-finger
IPB001841 Zn-finger


UniProtKB/Swiss-Prot: R113B_HUMAN, Q8IZP6
Similarity: Contains 1 C3H1-type zinc finger
Similarity: Contains 1 RING-type zinc finger


RNF113B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
GO:0046872metal ion binding ----
     
RNF113B for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF113B

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for RNF113B (Q8IZP63 ENSP000002672914) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
UBE2R2Q712K33, ENSP000002632284I2D: score=2 STRING: ENSP00000263228
UBE2UQ5VVX93, ENSP000003601164I2D: score=1 STRING: ENSP00000360116
UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
UBE2L3P680363, ENSP000003442594I2D: score=2 STRING: ENSP00000344259
CDC5LENSP000003605324STRING: ENSP00000360532
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNF113B (R113B)

Search CenterWatch for drugs/clinical trials and news about RNF113B / R113B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF113B gene: 
NM_178861.4  

Unigene Cluster for RNF113B:

Ring finger protein 113B
Hs.296045  [show with all ESTs]
Unigene Representative Sequence: BC017585
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000267291(uc001vnk.3)
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Additional mRNA sequence: 

AF539427.1 BC017585.2 BC025388.1 

2 DOTS entries:

DT.120786864  DT.219833 

19 AceView cDNA sequences:

BX116709 BI459662 AI935007 BG718251 BI826627 AA883163 AA435942 NM_178861 
BC017585 AI204135 AW275115 BM554222 AF539427 BC025388 BI827854 AW241986 
BG720695 AI150219 AW183950 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF113B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GATGGATGAA
RNF113B Expression
About this image


See RNF113B Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.296045
    SABiosciences Custom PCR Arrays for RNF113B
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF113B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF113B gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves RNF113A6
ring finger protein 113A
58(a)
1 → many
27(2775142-2781204)
lizard
(Anolis carolinensis)
Reptilia --
--
59(a)
1 → many
6(60829355-60837266)
zebrafish
(Danio rerio)
Actinopterygii rnf113a6
ring finger protein 113A
56(a)
1 → many
3(32055943-32061563)
fruit fly
(Drosophila melanogaster)
Insecta CG49736
--
41(a)
1 → many
3R(15883472-15885013)
worm
(Caenorhabditis elegans)
Secernentea rnf-1136
RING finger protein 113 homolog
32(a)
1 → many
III(10755625-10757642)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CWC246
Essential protein, component of a complex containi...
28(a)
1 → many
XII(778173-778952)
        Species with no ortholog for RNF113B

ENSEMBL Gene Tree for RNF113B (if available)
TreeFam Gene Tree for RNF113B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RNF113B gene
RNF113A2  
2 SIMAP similar genes for RNF113B using alignment to 1 protein entry:     R113B_HUMAN:
RNF113A    SAMD13

RNF113B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

1 SNPs in RNF113B are shown    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0521044
----see VAR_0521042 V M mis40--------

HapMap Linkage Disequilibrium report for RNF113B (98828039 - 98829521 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for RNF113B:    About this table     
Variant IDTypeSubtypePubMed ID
nsv7246OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for RNF113B:    About MalaCards
keratoconus    

1 disease from the University of Copenhagen DISEASES database for RNF113B:
Keratoconus

RNF113B for disorders           About GeneDecksing


Export disorders for RNF113B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RNF113B gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNF113B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
  4. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 140432 HGNC: 17267 AceView: ZNF183L1 Ensembl:ENSG00000139797 euGenes: HUgn140432
ECgene: RNF113B H-InvDB: RNF113B

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RNF113B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RNF113B gene:
Search GeneIP for patents involving RNF113B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF113B
 SwitchGear 3'UTR luciferase reporter plasmids for RNF113B
 SwitchGear Promoter luciferase reporter plasmids for RNF113B
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF113B
 inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF113B
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNF113B
Customized:
 lentivirus for stable overexpression of RNF113B
 lentivirus expression plasmids for stable overexpression of RNF113B
 adenovirus for overexpression of RNF113B
 LSBio Antibodies in human, mouse, rat for RNF113B
Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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