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RNF113A Gene

protein-coding   GIFtS: 50
GCID: GC0XM119004

Ring Finger Protein 113A

(Previous names: zinc finger protein 183 (RING finger, C3HC4 type))
(Previous symbol: ZNF183)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 113A1 2
ZNF1831 2 3
Zinc Finger Protein 183 (RING Finger, C3HC4 Type)1 2
RNF1132 3
Cwc242
Zinc Finger Protein 1833

External Ids:    HGNC: 129741   Entrez Gene: 77372   Ensembl: ENSG000001253527   UniProtKB: O155413   

Export aliases for RNF113A gene to outside databases

Previous GC identifers: GC0XM118787 GC0XM118888 GC0XM108497


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF113A Gene:
This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really
Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor
suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating
protein-protein interactions. (provided by RefSeq, May 2010)

GeneCards Summary for RNF113A Gene:
RNF113A (ring finger protein 113A) is a protein-coding gene. An important paralog of this gene is RNF113B.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF113A gene promoter:
         AML1a   Arnt   GATA-2   C/EBPalpha   YY1   MZF-1   POU2F1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF113A promoter sequence
   Search Chromatin IP Primers for RNF113A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF113A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq24   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq24

RNF113A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF113A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM119004:  view genomic region     (about GC identifiers)

Start:
119,004,495 bp from pter      End:
119,005,791 bp from pter
Size:
1,297 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: R113A_HUMAN, O15541 (See protein sequence)
Recommended Name: RING finger protein 113A  
Size: 343 amino acids; 38787 Da

Explore the universe of human proteins at neXtProt for RNF113A: NX_O15541

Explore proteomics data for RNF113A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF113A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008909.1  
    ENSEMBL proteins: 
     ENSP00000360497  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O15541

    ProtoNet protein and cluster: O15541

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: R113A_HUMAN, O15541
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with RNF113A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RNF113A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF113A:
     Decreased nuclei size in G2M  Increased cell death in HCT116 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNF113A: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RNF113A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF113A (O155411, 2, 3 ENSP000003604974) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKQ131231, 2, ENSP000003963014EBI-2130294,EBI-713456 MINT-8332295 MINT-8337563 STRING: ENSP00000396301
    SNRNP200O756431, 2, ENSP000003171234EBI-2130294,EBI-1045395 MINT-8332284 MINT-8336089 STRING: ENSP00000317123
    SF3B2Q134351, 2, ENSP000003188614EBI-2130294,EBI-749111 MINT-8332405 MINT-8333735 STRING: ENSP00000318861
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    ILF3Q129062, ENSP000004041214MINT-8335528 STRING: ENSP00000404121
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF113A (R113A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNF113A gene: 
    NM_006978.2  

    Unigene Cluster for RNF113A:

    Ring finger protein 113A
    Hs.458365  [show with all ESTs]
    Unigene Representative Sequence: BM924989
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371442(uc004esb.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF113A
      QuantiFast Probe-based Assays in human, mouse, rat RNF113A

    Additional mRNA sequence: 

    AF086291.1 AK314778.1 BC000832.1 BC020556.1 BC128440.1 BT007175.1 X98253.1 

    5 DOTS entries:

    DT.99986836  DT.213460  DT.121289703  DT.91984375  DT.97861853 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF113A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGCAGAT
    RNF113A Expression
    About this image

    RNF113A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF113A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.458365

    UniProtKB/Swiss-Prot: R113A_HUMAN, O15541
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF113A: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF113A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf113a15
    Rnf113a21
    ring finger protein 113A15
    ring finger protein 113A21
    85.07(n)1
    91.34(a)1
      X (21.61 cM)5
    663811  NM_025525.21  NP_079801.21 
     371912455 
    chicken
    (Gallus gallus)
    Aves RNF113A6
    Gallus gallus ring finger protein 113A (RNF113A), ...
    77(a)
    1 → many
    27(2775142-2781204)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    77(a)
    1 → many
    6(60829355-60837266)
    zebrafish
    (Danio rerio)
    Actinopterygii rnf113a6
    ring finger protein 113A
    72(a)
    1 → many
    3(32056018-32061619) ENSDARG00000037930
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49736
    --
    52(a)
    1 → many
    3R(15883472-15885013)
    worm
    (Caenorhabditis elegans)
    Secernentea rnf-1136
    Protein RNF-113 (rnf-113) mRNA, complete cds
    38(a)
    1 → many
    III(10755625-10757642) WBGene00010476
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CWC246
    Essential protein, component of a complex containi...
    33(a)
    1 → many
    XII(778173-778952) YLR323C
    rice
    (Oryza sativa)
    Liliopsida AK106298.12   -- 77.55(n)    AK106298.1 


    ENSEMBL Gene Tree for RNF113A (if available)
    TreeFam Gene Tree for RNF113A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF113A gene
    RNF113B2  
    2 SIMAP similar genes for RNF113A using alignment to 1 protein entry:     R113A_HUMAN:
    SAMD13    RNF113B

    Find genes that share paralogs with RNF113A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNF113A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7057CNV Insertion18451855
    dgv2469e1CNV Complex17122850
    dgv2468e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): RNF113A
    Locus Specific Mutation Databases (LSDB): RNF113A

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RNF113A           About GenesLikeMe


    Export disorders for RNF113A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF113A gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with RNF113A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25. (PubMed id 9224902)1, 2, 3 Frattini A.... Vezzoni P. (Gene 1997)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    6. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    7. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (J. Cell Biol. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7737 HGNC: 12974 Ensembl:ENSG00000125352 euGenes: HUgn7737 ECgene: RNF113A
    H-InvDB: RNF113A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF113A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF113A gene:
    Search GeneIP for patents involving RNF113A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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