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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF113A Gene

protein-coding   GIFtS: 49
GCID: GC0XM119004

Ring Finger Protein 113A

(Previous names: zinc finger protein 183 (RING finger, C3HC4 type))
(Previous symbol: ZNF183)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 113A1 2
ZNF1831 2 3
Zinc Finger Protein 183 (RING Finger, C3HC4 Type)1 2
RNF1132 3
Cwc242
Zinc Finger Protein 1833

External Ids:    HGNC: 129741   Entrez Gene: 77372   Ensembl: ENSG000001253527   UniProtKB: O155413   

Export aliases for RNF113A gene to outside databases

Previous GC identifers: GC0XM118787 GC0XM118888 GC0XM108497


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF113A Gene:
This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really
Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor
suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating
protein-protein interactions. (provided by RefSeq, May 2010)

GeneCards Summary for RNF113A Gene: 
RNF113A (ring finger protein 113A) is a protein-coding gene. Diseases associated with RNF113A include prostate cancer, and prostatitis. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is RNF113B.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011786.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF113A gene promoter:
         AML1a   Arnt   GATA-2   C/EBPalpha   YY1   MZF-1   POU2F1   POU2F1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF113A promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF113A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF113A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25-q26   Ensembl cytogenetic band:  Xq24   HGNC cytogenetic band: Xq25-q26

RNF113A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF113A gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM119004:  view genomic region     (about GC identifiers)

Start:
119,004,495 bp from pter      End:
119,005,791 bp from pter
Size:
1,297 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: R113A_HUMAN, O15541 (See protein sequence)
Recommended Name: RING finger protein 113A  
Size: 343 amino acids; 38787 Da

Explore the universe of human proteins at neXtProt for RNF113A: NX_O15541

Explore proteomics data for RNF113A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15541

  • RNF113A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNF113A Protein Expression
    REFSEQ proteins: NP_008909.1  
    ENSEMBL proteins: 
     ENSP00000360497  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR000571 Znf_CCCH
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O15541

    ProtoNet protein and cluster: O15541

    2 Blocks protein domains:
    IPB000571 Zn-finger
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: R113A_HUMAN, O15541
    Similarity: Contains 1 C3H1-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    RNF113A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF113A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF113A:
     Decreased nuclei size in G2M  Increased cell death in HCT116 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF113A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/18 Interacting proteins for RNF113A (O155412, 3 ENSP000003604974) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SF3B2Q134352, ENSP000003188614MINT-8332405 MINT-8333735 STRING: ENSP00000318861
    IKQ131232, ENSP000003963014MINT-8332295 MINT-8337563 STRING: ENSP00000396301
    SNRNP200O756432, ENSP000003171234MINT-8332284 MINT-8336089 STRING: ENSP00000317123
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    ILF3Q129062, ENSP000004041214MINT-8335528 STRING: ENSP00000404121
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF113A (R113A)

    Search CenterWatch for drugs/clinical trials and news about RNF113A / R113A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF113A gene: 
    NM_006978.2  

    Unigene Cluster for RNF113A:

    Ring finger protein 113A
    Hs.458365  [show with all ESTs]
    Unigene Representative Sequence: BM924989
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371442(uc004esb.3)
    miRNA
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    Additional mRNA sequence: 

    AF086291.1 AK314778.1 BC000832.1 BC020556.1 BC128440.1 BT007175.1 X98253.1 

    5 DOTS entries:

    DT.99986836  DT.213460  DT.121289703  DT.91984375  DT.97861853 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF113A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGCAGAT
    RNF113A Expression
    About this image


    See RNF113A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF113A

    SOURCE GeneReport for Unigene cluster: Hs.458365

    UniProtKB/Swiss-Prot: R113A_HUMAN, O15541
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including RNF113A: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF113A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF113A gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf113a11 , 5 ring finger protein 113A11, 5 87.06(n)1
    88.53(a)1
      X (21.61 cM)5
    699421  NM_153503.11  NP_705723.11 
     371912455 
    chicken
    (Gallus gallus)
    Aves RNF113A1 ring finger protein 113A 72.24(n)
    78.55(a)
      419956  NM_001004396.1  NP_001004396.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    77(a)
    1 → many
    6(60829355-60837266)
    zebrafish
    (Danio rerio)
    Actinopterygii rnf113a1 ring finger protein 113A 68.64(n)
    74.45(a)
      446116  NM_001004536.1  NP_001004536.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG49731 CG4973 59.3(n)
    59.41(a)
      42397  NM_142608.3  NP_650865.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rnf-1131 Protein RNF-113 48.08(n)
    45.51(a)
      176507  NM_066974.3  NP_499375.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CWC241 Cwc24p 47.31(n)
    35.48(a)
      851033   NP_013427.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G013501 zinc finger CCCH domain-containing protein 1 52.2(n)
    46.78(a)
      838964  NM_100017.2  NP_171642.2 
    rice
    (Oryza sativa)
    Liliopsida AK106298.12   -- 77.55(n)    AK106298.1 


    ENSEMBL Gene Tree for RNF113A (if available)
    TreeFam Gene Tree for RNF113A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF113A gene
    RNF113B2  
    2 SIMAP similar genes for RNF113A using alignment to 1 protein entry:     R113A_HUMAN:
    SAMD13    RNF113B

    RNF113A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNF113A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7057CNV Insertion18451855
    dgv2469e1CNV Complex17122850
    dgv2468e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): RNF113A

    Locus Specific Mutation Databases (LSDB): RNF113A
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RNF113A:    About MalaCards
    prostate cancer    prostatitis


    RNF113A for disorders           About GeneDecksing


    Export disorders for RNF113A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF113A gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with RNF113A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25. (PubMed id 9224902)1, 2, 3 Frattini A.... Vezzoni P. (1997)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    6. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    7. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PubMed id 22412018)1 Roux K.J.... Burke B. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7737 HGNC: 12974 Ensembl:ENSG00000125352 euGenes: HUgn7737 ECgene: RNF113A
    H-InvDB: RNF113A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF113A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF113A gene:
    Search GeneIP for patents involving RNF113A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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