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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF112 Gene

protein-coding   GIFtS: 45
GCID: GC17P019314

Ring Finger Protein 112

(Previous name: zinc finger protein 179)
(Previous symbol: ZNF179)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein 1121 2
ZNF1791 2 3 5
Zinc Finger Protein 1791 2 3
BFP2 3 5
Brain Finger Protein2 3

External Ids:    HGNC: 129681   Entrez Gene: 77322   Ensembl: ENSG000001284827   OMIM: 6012375   UniProtKB: Q9ULX53   

Export aliases for RNF112 gene to outside databases

Previous GC identifers: GC17P019257 GC17P018694


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF112 Gene:
This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily
expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RNF112 Gene: 
RNF112 (ring finger protein 112) is a protein-coding gene. Diseases associated with RNF112 include accommodative esotropia, and suppression amblyopia. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ATL3.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF112 gene promoter:
         AhR   HOXA9B   HOXA9   SRF   Bach2   SRF (504 AA)   Tal-1beta   Meis-1b   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNF112 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF112

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF112


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

RNF112 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF112 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P019314:  view genomic region     (about GC identifiers)

Start:
19,314,438 bp from pter      End:
19,320,589 bp from pter
Size:
6,152 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN112_HUMAN, Q9ULX5 (See protein sequence)
Recommended Name: RING finger protein 112  
Size: 631 amino acids; 68298 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: O60633 Q7Z5V9
Alternative splicing: 2 isoforms:  Q9ULX5-1   Q9ULX5-2   

Explore the universe of human proteins at neXtProt for RNF112: NX_Q9ULX5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULX5

  • RNF112 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_009079.2  
    ENSEMBL proteins: 
     ENSP00000464134   ENSP00000454919  

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    Browse Sino Biological Cell Lysates 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0016021integral to membrane IEA--

    RNF112 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR027417 P-loop_NTPase
     IPR015894 Guanylate-bd_N
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9ULX5

    ProtoNet protein and cluster: Q9ULX5

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RN112_HUMAN, Q9ULX5
    Similarity: Contains 1 RING-type zinc finger


    RNF112 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
    GO:0008270zinc ion binding NAS8660987
         
    RNF112 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RNF112:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNF112 
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    hsa-miR-155* hsa-miR-1264
    SwitchGear 3'UTR luciferase reporter plasmidRNF112 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for RNF112
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF112

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF112 (RN112)

    Search CenterWatch for drugs/clinical trials and news about RNF112 / RN112

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNF112 gene: 
    NM_007148.4  

    Unigene Cluster for RNF112:

    Ring finger protein 112
    Hs.189482  [show with all ESTs]
    Unigene Representative Sequence: NM_007148
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000575165 ENST00000574149(uc010vyu.2) ENST00000461366(uc010vyw.2 uc021tsa.1)
    ENST00000580109 ENST00000574782
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate RNF112:
    hsa-miR-155* hsa-miR-1264
    SwitchGear 3'UTR luciferase reporter plasmidRNF112 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNF112
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    Clone
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    OriGene clones in human, mouse for RNF112 (see all 7)
    OriGene ORF clones in mouse, rat for RNF112
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNF112 (NM_007148)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF112
    Sirion Biotech Customized lentivirus for stable overexpression of RNF112 
                         Customized lentivirus expression plasmids for stable overexpression of RNF112 
    Primer
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    OriGene qPCR primer pairs and template standards for RNF112
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF112
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF112

    Additional mRNA sequence: 

    AB026054.1 AK226052.1 AK293508.1 AK313844.1 BC038896.1 BC053989.1 

    2 DOTS entries:

    DT.40198862  DT.75116798 

    24/53 AceView cDNA sequences (see all 53):

    AI631700 BX116914 BC038896 BF514637 BU631924 BC053989 BM931830 AI589846 
    AB026054 BM930108 AW005893 NM_007148 BM669827 BM716143 BE466003 AL157643 
    AW136856 AI810765 BM931822 AI675156 D80746 BM083873 AI659353 BI820061 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF112 expression in normal human tissues (normalized intensities)      RNF112 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCTGTGA
    RNF112 Expression
    About this image


    RNF112 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Brain Pericytes   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Smooth Muscle (Muscoskeletal System)
             Human Bladder Smooth Muscle Cells (HBdSMC)   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7PEND24, NCr-fac & Meso-prx Progenitor

    Genevestigator expression for RNF112

    SOURCE GeneReport for Unigene cluster: Hs.189482

    UniProtKB/Swiss-Prot: RN112_HUMAN, Q9ULX5
    Tissue specificity: Predominantly expressed in brain

        SABiosciences Custom PCR Arrays for RNF112
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF112

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RNF112 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf1121 , 5 ring finger protein 1121, 5 84.39(n)1
    88.41(a)1
      11 (37.96 cM)5
    226711  NM_009548.21  NP_033574.21 
     614484425 
    lizard
    (Anolis carolinensis)
    Reptilia RNF1126
    Uncharacterized protein
    35(a)
    1 ↔ 1
    GL343287.1(1724210-1737027)
    fruit fly
    (Drosophila melanogaster)
    Insecta atl6
    atlastin
    18(a)
    1 → many
    3R(20451397-20460436)
    worm
    (Caenorhabditis elegans)
    Secernentea Y41E3.36
    Y54G2A.26
    Protein Y54G2A.2, isoform a
    18(a)
    17(a)
    possible ortholog
    1 ↔ many
    IV(14981609-14996316)
    IV(2788690-2796813)


    ENSEMBL Gene Tree for RNF112 (if available)
    TreeFam Gene Tree for RNF112 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF112 gene
    ATL32  ATL22  ATL12  
    5 SIMAP similar genes for RNF112 using alignment to 2 protein entries:     RN112_HUMAN (see all proteins):
    TRIM39    TRIM17    TRIM26    BFAR    TRIM5

    RNF112 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 SNPs in RNF112 are shown (see all 186)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487453291,2
    --19312621(+) CCTTTG/TTTCCC 1 -- us2k10--------
    rs1895645681,2
    --19312705(+) ACCTCC/TTTGCT 1 -- us2k10--------
    rs1425958861,2
    --19312727(+) CCTGAC/TACCCC 1 -- us2k10--------
    rs1464910241,2
    --19312744(+) CCCTCA/CCCGCA 1 -- us2k10--------
    rs1808038331,2
    --19312789(+) TAATTG/TTCCAG 1 -- us2k10--------
    rs1151576931,2
    C,F--19312950(+) GGAAGC/TTCAGA 1 -- us2k10--------
    rs1864845121,2
    --19313217(+) TTCTCC/TGAATC 1 -- us2k10--------
    rs790475891,2
    C,F--19313266(+) CCAAAA/GTGAAC 1 -- us2k11Minor allele frequency- G:0.16EA 120
    rs1893578211,2
    --19313328(+) GCTGAA/TCTTTT 1 -- us2k10--------
    rs733079161,2
    C,F--19313336(+) TTTCTC/AGGTTC 1 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for RNF112 (19314438 - 19320589 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RNF112: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF112
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF112

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601237    OMIM disorders: --

    12 diseases for RNF112:    About MalaCards
    accommodative esotropia    suppression amblyopia    sneddon syndrome    facial paralysis
    esotropia    amblyopia    smith magenis syndrome    syphilis
    paralysis    diarrhea    fanconi's anemia    anemia

    2 diseases from the University of Copenhagen DISEASES database for RNF112:
    Syphilis     Diarrhea

    RNF112 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNF112

    Export disorders for RNF112 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF112 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNF112)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosome mapping of human (ZNF179), mouse, and rat genes for brain finger protein (bfp), a member of the RING finger family. (PubMed id 8660987)1, 2, 3, 9 Matsuda Y....Hori T. (1996)
    2. Molecular cloning, localization, and developmental expression of mouse brain finger protein (Bfp)/ZNF179: distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis syndrome. (PubMed id 9806830)1, 3, 9 Orimo A....Muramatsu M. (1998)
    3. cDNA cloning of a human brain finger protein, BFP/ZNF179, a member of the RING finger protein family. (PubMed id 10574464)1, 2 Seki N.... Saito T. (1999)
    4. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
    5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. The brain finger protein gene (ZNF179), a member of the RING finger family, maps within the Smith-Magenis syndrome region at 17p11.2. (PubMed id 9096764)1 Kimura T....Inazawa J. (1997)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7732 HGNC: 12968 AceView: ZNF179 Ensembl:ENSG00000128482 euGenes: HUgn7732
    ECgene: RNF112 H-InvDB: RNF112

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF112 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNF112 gene:
    Search GeneIP for patents involving RNF112

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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