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Aliases for RNF112 Gene

Aliases for RNF112 Gene

  • Ring Finger Protein 112 2 3 5
  • Zinc Finger Protein 179 2 3 4
  • Brain Finger Protein 3 4
  • Neurolastin 2 3
  • ZNF179 3 4
  • BFP 3 4

External Ids for RNF112 Gene

Previous HGNC Symbols for RNF112 Gene

  • ZNF179

Previous GeneCards Identifiers for RNF112 Gene

  • GC17P019257
  • GC17P018694
  • GC17P019314

Summaries for RNF112 Gene

Entrez Gene Summary for RNF112 Gene

  • This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF112 Gene

RNF112 (Ring Finger Protein 112) is a Protein Coding gene. Diseases associated with RNF112 include Smith-Magenis Syndrome. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ATL2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF112 Gene

Genomics for RNF112 Gene

Regulatory Elements for RNF112 Gene

Enhancers for RNF112 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF112 on UCSC Golden Path with GeneCards custom track

Promoters for RNF112 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF112 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF112 Gene

Chromosome:
17
Start:
19,410,790 bp from pter
End:
19,417,276 bp from pter
Size:
6,487 bases
Orientation:
Plus strand

Genomic View for RNF112 Gene

Genes around RNF112 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF112 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF112 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF112 Gene

Proteins for RNF112 Gene

  • Protein details for RNF112 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULX5-RN112_HUMAN
    Recommended name:
    RING finger protein 112
    Protein Accession:
    Q9ULX5
    Secondary Accessions:
    • O60633
    • Q7Z5V9

    Protein attributes for RNF112 Gene

    Size:
    631 amino acids
    Molecular mass:
    68298 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF112 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF112 Gene

Proteomics data for RNF112 Gene at MOPED

Post-translational modifications for RNF112 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF112 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for RNF112

No data available for DME Specific Peptides for RNF112 Gene

Domains & Families for RNF112 Gene

Gene Families for RNF112 Gene

Suggested Antigen Peptide Sequences for RNF112 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULX5

UniProtKB/Swiss-Prot:

RN112_HUMAN :
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF112: view

Function for RNF112 Gene

Gene Ontology (GO) - Molecular Function for RNF112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RNF112: view
genes like me logo Genes that share phenotypes with RNF112: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF112 Gene

Localization for RNF112 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF112 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF112 Gene COMPARTMENTS Subcellular localization image for RNF112 gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 2
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RNF112 Gene

Pathways & Interactions for RNF112 Gene

SuperPathways for RNF112 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF112 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045666 positive regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with RNF112: view

No data available for Pathways by source and SIGNOR curated interactions for RNF112 Gene

Drugs & Compounds for RNF112 Gene

No Compound Related Data Available

Transcripts for RNF112 Gene

Unigene Clusters for RNF112 Gene

Ring finger protein 112:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF112 Gene

No ASD Table

Relevant External Links for RNF112 Gene

GeneLoc Exon Structure for
RNF112
ECgene alternative splicing isoforms for
RNF112

Expression for RNF112 Gene

mRNA expression in normal human tissues for RNF112 Gene

mRNA differential expression in normal tissues according to GTEx for RNF112 Gene

This gene is overexpressed in Brain - Cerebellum (x8.5) and Brain - Cerebellar Hemisphere (x8.0).

Protein differential expression in normal tissues from HIPED for RNF112 Gene

This gene is overexpressed in CD4 Tcells (64.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF112 Gene



SOURCE GeneReport for Unigene cluster for RNF112 Gene Hs.189482

mRNA Expression by UniProt/SwissProt for RNF112 Gene

Q9ULX5-RN112_HUMAN
Tissue specificity: Predominantly expressed in brain.
genes like me logo Genes that share expression patterns with RNF112: view

Protein tissue co-expression partners for RNF112 Gene

- Elite partner

Primer Products

Orthologs for RNF112 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF112 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF112 35
  • 84.85 (n)
  • 85.65 (a)
RNF112 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF112 35
  • 86.84 (n)
  • 88.69 (a)
RNF112 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf112 35
  • 84.29 (n)
  • 88.25 (a)
Rnf112 16
Rnf112 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF112 35
  • 99.63 (n)
  • 99.84 (a)
rat
(Rattus norvegicus)
Mammalia Rnf112 35
  • 84.39 (n)
  • 88.73 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia RNF112 36
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf112 35
  • 51.09 (n)
  • 37.12 (a)
zebrafish
(Danio rerio)
Actinopterygii RNF112 36
  • 13 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta atl 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atln-1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for RNF112:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF112 Gene

ENSEMBL:
Gene Tree for RNF112 (if available)
TreeFam:
Gene Tree for RNF112 (if available)

Paralogs for RNF112 Gene

Paralogs for RNF112 Gene

(5) SIMAP similar genes for RNF112 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNF112: view

Variants for RNF112 Gene

Sequence variations from dbSNP and Humsavar for RNF112 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs739829 -- 19,411,963(-) CCTCC(A/G)CAACC intron-variant, upstream-variant-2KB
rs739830 -- 19,411,298(+) CCTTC(C/T)ACCTA upstream-variant-2KB, utr-variant-5-prime
rs1110466 -- 19,410,684(-) CCTCC(A/G)TGTCC upstream-variant-2KB
rs1110467 -- 19,410,402(-) CTCTC(A/G)CCCCA upstream-variant-2KB
rs1295329 -- 19,415,702(-) GTCCT(A/G)TGACA intron-variant

Variation tolerance for RNF112 Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RNF112 Gene

Disorders for RNF112 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF112 Gene - From: GeneCards

Disorder Aliases PubMed IDs
smith-magenis syndrome
  • smith magenis syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RNF112

Genetic Association Database (GAD)
RNF112
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF112
genes like me logo Genes that share disorders with RNF112: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF112 Gene

Publications for RNF112 Gene

  1. Chromosome mapping of human (ZNF179), mouse, and rat genes for brain finger protein (bfp), a member of the RING finger family. (PMID: 8660987) Matsuda Y. … Hori T. (Genomics 1996) 2 3 4 23 67
  2. Molecular cloning, localization, and developmental expression of mouse brain finger protein (Bfp)/ZNF179: distribution of bfp mRNA partially coincides with the affected areas of Smith-Magenis syndrome. (PMID: 9806830) Orimo A. … Muramatsu M. (Genomics 1998) 2 3 23
  3. Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density. (PMID: 26212327) Lomash R.M. … Roche K.W. (Cell Rep 2015) 2 3
  4. Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf). (PMID: 24359566) Lin D.Y. … Lee Y.C. (J. Biomed. Sci. 2013) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RNF112 Gene

Sources for RNF112 Gene

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