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Aliases for RNF111 Gene

Aliases for RNF111 Gene

  • Ring Finger Protein 111 2 3
  • E3 Ubiquitin-Protein Ligase Arkadia 3
  • RING Finger Protein 111 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • Arkadia 3
  • ARK 3

External Ids for RNF111 Gene

Summaries for RNF111 Gene

Entrez Gene Summary for RNF111 Gene

  • The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for RNF111 Gene

RNF111 (Ring Finger Protein 111) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin-protein transferase activity and SUMO polymer binding. An important paralog of this gene is RNF165.

UniProtKB/Swiss-Prot for RNF111 Gene

  • Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.

Gene Wiki entry for RNF111 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF111 Gene

Genomics for RNF111 Gene

Genomic Location for RNF111 Gene

Start:
58,865,175 bp from pter
End:
59,097,419 bp from pter
Size:
232,245 bases
Orientation:
Plus strand

Genomic View for RNF111 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF111 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF111 Gene

Regulatory Elements for RNF111 Gene

Proteins for RNF111 Gene

  • Protein details for RNF111 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNA4-RN111_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase Arkadia
    Protein Accession:
    Q6ZNA4
    Secondary Accessions:
    • C9JUS4
    • H0YN55
    • Q6P9A4
    • Q6ZMU2
    • Q7L428
    • Q7Z346
    • Q8N1P9
    • Q8WUA3
    • Q9NSR1

    Protein attributes for RNF111 Gene

    Size:
    994 amino acids
    Molecular mass:
    108862 Da
    Quaternary structure:
    • Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7. Interacts (via SIM domains) with SUMO1 and SUMO2.
    SequenceCaution:
    • Sequence=AAH10369.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04531.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD18633.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF111 Gene

    Alternative splice isoforms for RNF111 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF111 Gene

Proteomics data for RNF111 Gene at MOPED

Post-translational modifications for RNF111 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys927

Other Protein References for RNF111 Gene

Domains for RNF111 Gene

Gene Families for RNF111 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF111 Gene

Suggested Antigen Peptide Sequences for RNF111 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNA4

UniProtKB/Swiss-Prot:

RN111_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q6ZNA4
genes like me logo Genes that share domains with RNF111: view

Function for RNF111 Gene

Molecular function for RNF111 Gene

UniProtKB/Swiss-Prot Function: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.

Enzyme Numbers (IUBMB) for RNF111 Gene

Gene Ontology (GO) - Molecular Function for RNF111 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 16601693
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0032184 SUMO polymer binding IDA 23086935
genes like me logo Genes that share ontologies with RNF111: view

Phenotypes for RNF111 Gene

genes like me logo Genes that share phenotypes with RNF111: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF111 Gene

Localization for RNF111 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF111 Gene

Nucleus. Cytoplasm. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF111 Gene COMPARTMENTS Subcellular localization image for RNF111 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RNF111 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with RNF111: view

Pathways for RNF111 Gene

genes like me logo Genes that share pathways with RNF111: view

Pathways by source for RNF111 Gene

1 BioSystems pathway for RNF111 Gene

UniProtKB/Swiss-Prot Q6ZNA4-RN111_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF111 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006351 transcription, DNA-templated TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0007389 pattern specification process IEA --
genes like me logo Genes that share ontologies with RNF111: view

Transcripts for RNF111 Gene

Unigene Clusters for RNF111 Gene

Ring finger protein 111:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF111 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - -
SP7:
SP8: -

Relevant External Links for RNF111 Gene

GeneLoc Exon Structure for
RNF111
ECgene alternative splicing isoforms for
RNF111

Expression for RNF111 Gene

mRNA expression in normal human tissues for RNF111 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF111 Gene

SOURCE GeneReport for Unigene cluster for RNF111 Gene Hs.404423

mRNA Expression by UniProt/SwissProt for RNF111 Gene

Q6ZNA4-RN111_HUMAN
Tissue specificity: Broadly expressed.
genes like me logo Genes that share expressions with RNF111: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNF111 Gene

Orthologs for RNF111 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF111 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF111 35
  • 99.66 (n)
  • 99.8 (a)
RNF111 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF111 35
  • 94.13 (n)
  • 95.97 (a)
RNF111 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF111 35
  • 94.53 (n)
  • 96.88 (a)
RNF111 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf111 35
  • 88.74 (n)
  • 91 (a)
Rnf111 16
Rnf111 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF111 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rnf111 35
  • 88.15 (n)
  • 91.19 (a)
chicken
(Gallus gallus)
Aves RNF111 35
  • 82.48 (n)
  • 87.78 (a)
RNF111 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF111 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia arkadia 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf111 35
  • 73.28 (n)
  • 75.84 (a)
Str.17326 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6895 35
zebrafish
(Danio rerio)
Actinopterygii rnf111 35
  • 61.14 (n)
  • 62.28 (a)
RNF111 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6923 36
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea toe-4 36
  • 18 (a)
OneToMany
Species with no ortholog for RNF111:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF111 Gene

ENSEMBL:
Gene Tree for RNF111 (if available)
TreeFam:
Gene Tree for RNF111 (if available)

Paralogs for RNF111 Gene

Paralogs for RNF111 Gene

Selected SIMAP similar genes for RNF111 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNF111: view

Variants for RNF111 Gene

Sequence variations from dbSNP and Humsavar for RNF111 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs745800 -- 59,095,793(-) CTTTT(C/G)GTGCT utr-variant-3-prime
rs877269 -- 59,081,595(+) CTCAT(A/T)CCCGT intron-variant
rs935363 -- 59,069,478(-) CATAA(C/T)TGATG intron-variant
rs935364 -- 59,010,046(-) AAAAA(A/G)AATTG intron-variant
rs1014443 -- 59,045,598(-) CAATT(C/T)GACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF111 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
nsv904254 CNV Gain 21882294
esv34110 CNV Loss 18971310
nsv527307 CNV Gain 19592680
nsv904271 CNV Loss 21882294
dgv151n21 CNV Gain 19592680
nsv510663 CNV Loss 20534489
nsv833025 CNV Gain 17160897
nsv520769 CNV Gain 19592680
nsv819459 CNV Loss 19587683

Relevant External Links for RNF111 Gene

HapMap Linkage Disequilibrium report
RNF111

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF111 Gene

Disorders for RNF111 Gene

Relevant External Links for RNF111

Genetic Association Database (GAD)
RNF111
genes like me logo Genes that share disorders with RNF111: view

No data available for UniProtKB/Swiss-Prot for RNF111 Gene

Publications for RNF111 Gene

  1. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. (PMID: 17591695) Levy L. … Hill C.S. (Mol. Cell. Biol. 2007) 3 4
  2. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. (PMID: 11298452) Episkopou V. … Swan D. (Nature 2001) 2 3
  3. Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7. (PMID: 14657019) Koinuma D. … Miyazono K. (EMBO J. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RNF111 Gene

Sources for RNF111 Gene

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