Aliases for RNF111 Gene
External Ids for RNF111 Gene
Previous GeneCards Identifiers for RNF111 Gene
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for RNF111 Gene
RNF111 (Ring Finger Protein 111) is a Protein Coding gene. Diseases associated with RNF111 include subclavian steal syndrome. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is RNF165.
UniProtKB/Swiss-Prot for RNF111 Gene
Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme.