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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNF111 Gene

protein-coding GIFtS: 54
GCID: GC15P059160

ring finger protein 111

Explore 5 diseases affiliated with
RNF111 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ring Finger Protein 111¹ ² ³		FLJ38008¹
ARK¹ ²		E3 Ubiquitin-Protein Ligase Arkadia²
Arkadia¹ ²		EC 6.3.2.-³
DKFZP761D081¹		EC 6.3.2⁸

External Ids:	HGNC: 17384¹	Entrez Gene: 54778²	Ensembl: ENSG00000157450⁷	OMIM: 605840⁵	UniProtKB: Q6ZNA4³

Export aliases for RNF111 gene to outside databases

Previous GC identifers: GC15P056902 GC15P056995 GC15P057067 GC15P059279 GC15P036102

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNF111:

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with

the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal

degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a

modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during

embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct

isoforms. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: RN111_HUMAN, Q6ZNA4

Function: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3

ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their

proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates

Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

Gene Wiki entry for RNF111

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNF111 gene promoter:
LHX3b/Lhx3b Pbx1a AP-1 AML1a p300 AP-4 Evi-1 GATA-1 POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNF111 promoter sequence

Search SABiosciences Chromatin IP Primers for RNF111

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF111

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21 Ensembl cytogenetic band: 15q22.1 HGNC cytogenetic band: 15q21

RNF111 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF111 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P059160: view genomic region (about GC identifiers)

Start:	59,157,374 bp from pter	End:	59,389,618 bp from pter
Size:	232,245 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RN111_HUMAN, Q6ZNA4 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase Arkadia

Size: 994 amino acids; 108862 Da

Subunit: Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1

and SMAD7. Interacts (via SIM domains) with SUMO1 and SUMO2

Subcellular location: Nucleus. Cytoplasm. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol

Sequence caution: Sequence=AAH10369.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAC04531.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAD18633.1;

Type=Erroneous initiation; Note=Translation N-terminally extended;

1 PDB 3D structure from and Proteopedia for RNF111:

2KIZ (3D)

Secondary accessions: C9JUS4 H0YN55 Q6P9A4 Q6ZMU2 Q7L428 Q7Z346 Q8N1P9 Q8WUA3 Q9NSR1

Alternative splicing: 4 isoforms: Q6ZNA4-1 Q6ZNA4-2 Q6ZNA4-3 Q6ZNA4-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF111: NX_Q6ZNA4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZNA4

4/16 DME Specific Peptides for RNF111 (Q6ZNA4) (see all 16)

NEFSHLC

RKRFVKN

PTVVPTTS

PPRLHHLQ

RNF111 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001257457.1 NP_001257458.1 NP_001257459.1 NP_060080.6

ENSEMBL proteins:

ENSP00000452919 ENSP00000288199 ENSP00000452842 ENSP00000453872 ENSP00000452732

ENSP00000453015 ENSP00000453248 ENSP00000393641

Reactome Protein details: Q6ZNA4
Human Recombinant Protein Products for RNF111:

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	Uscn Proteins for RNF111

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0043234	protein complex	IEA	--

RNF111 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNF111 for domains About GeneDecksing

2 InterPro domains/families:

IPR001841 Znf_RING

IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q6ZNA4

ProtoNet protein and cluster: Q6ZNA4

1 Blocks protein family: IPB001841 Zn-finger

UniProtKB/Swiss-Prot: RN111_HUMAN, Q6ZNA4

Similarity: Contains 1 RING-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RN111_HUMAN, Q6ZNA4

Function: Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3

ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their

proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates

Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

Enzyme Numbers (IUBMB): EC 6.3.2.-¹ EC 6.3.2²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IMP	16601693
GO:0005515	protein binding	IPI	16601693
GO:0008270	zinc ion binding	IEA	--
GO:0032184	SUMO polymer binding	IDA	--
GO:0046332	SMAD binding	IEA	--

RNF111 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RNF111:

Decreased homologous recombina

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rnf111):

embryogenesis

mortality/aging

nervous system

RNF111 for phenotypes About GeneDecksing

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF111

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	1.00			Signaling by TGF-beta Receptor Complex	0.61
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	0.63			Downregulation of SMAD2/3:SMAD4 transcriptional activity	0.56

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Generic Transcription Pathway

Generic Transcription Pathway

1.00

Gene Expression

0.46

TGF-beta receptor signaling

TGF-beta receptor signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for RNF111

TGF-beta receptor signaling

5/12 Reactome Pathways for RNF111 (see all 12)

	Generic Transcription Pathway
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Polyubiquitination of substrate
	Adaptive Immune System
	Signaling by TGF-beta Receptor Complex

UniProtKB/Swiss-Prot: RN111_HUMAN, Q6ZNA4

Pathway: Protein modification; protein ubiquitination

RNF111 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RNF111

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for RNF111 (Q6ZNA4^{2, 3} ENSP00000288199⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AXIN1	O15169²^,³, ENSP00000262320⁴	MINT-1899580 MINT-2778500 I2D: score=4 STRING: ENSP00000262320
SMURF2	Q9HAU4²^,³, ENSP00000262435⁴	MINT-61802 I2D: score=3 STRING: ENSP00000262435
SMAD7	O15105³, ENSP00000262158⁴	I2D: score=3 STRING: ENSP00000262158
UBE2I	P63279³, ENSP00000324897⁴	I2D: score=3 STRING: ENSP00000324897
SMAD2	Q15796³, ENSP00000262160⁴	I2D: score=2 STRING: ENSP00000262160

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	IEA	--
GO:0006351	transcription, DNA-dependent	TAS	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0007179	transforming growth factor beta receptor signaling pathway	TAS	--
GO:0007275	multicellular organismal development	--	--

RNF111 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Browse Tocris compounds for RNF111
Search CenterWatch for drugs/clinical trials and news about RNF111 / RN111

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNF111 gene (4 alternative transcripts):

NM_001270528.1 NM_001270529.1 NM_001270530.1 NM_017610.7

Unigene Cluster for RNF111:

Ring finger protein 111

Hs.404423 [show with all ESTs]

Unigene Representative Sequence: NM_001270528

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000559757 ENST00000348370(uc002afs.3 uc002afu.3) ENST00000559160

ENST00000559209(uc002afy.3) ENST00000557998 ENST00000561186 ENST00000559592

ENST00000558977 ENST00000559077 ENST00000560216 ENST00000560952 ENST00000560080

ENST00000434298(uc002aft.3 uc002afv.3 uc002afw.3 uc002afx.3)

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Additional cDNA sequence:

AK095327.1 AK131304.1 AK131488.1 AL157474.1 AL832089.1 BC010369.1 BC020984.1 BC060862.1

BX538130.1 BX647259.1

17 DOTS entries:

DT.87015781 DT.101983175 DT.316690 DT.445565 DT.100771334 DT.102826024 DT.97804066 DT.121067578

DT.91744104 DT.100780194 DT.121067580 DT.121067607 DT.405431 DT.92041939 DT.95151936 DT.95178864

DT.40266280

24/181 AceView cDNA sequences (see all 181):

BQ478140 AA348141 AA227819 AI634170 NM_017610 AW630050 M78396 BC020984

BQ772571 BU069560 AL157474 AA348294 AA643363 AW022275 AK095327 BC010369

BX282450 AA370826 AA281597 CB157405 AI480153 BX644476 BQ880725 D44628

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RNF111 (see all 8) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15a	·	15b	·	15c	^	16a	·	16b
SP1:					-		-																				-				-								-
SP2:					-		-																								-								-
SP3:							-																				-				-
SP4:					-		-																				-				-								-
SP5:																															-

ECgene alternative splicing isoforms for RNF111

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNF111 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATCATATGT

About this image
See RNF111 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNF111

SOURCE GeneReport for Unigene cluster: Hs.404423

UniProtKB/Swiss-Prot: RN111_HUMAN, Q6ZNA4

Tissue specificity: Broadly expressed

SABiosciences Expression via Pathway-Focused PCR Array including RNF111:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF111 gene from 9/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnf111^{1 , 5}	ring finger 111^{1, 5}	88.65(n)¹ 90.93(a)¹		9 (39.53 cM)⁵ 93836¹ NM_033604.2¹ NP_291082.1¹ 70425429⁵
chicken (Gallus gallus)	Aves	RNF111¹	ring finger protein 111	82.38(n) 87.78(a)		374021 NM_001199751.1 NP_001186680.1
lizard (Anolis carolinensis)	Reptilia	RNF111⁶	--	83(a)	1 ↔ 1	GL343573.1(166565-170804)
African clawed frog (Xenopus laevis)	Amphibia	arkadia²	ring finger-H2 protein	78.07(n)		AF329847.1
zebrafish (Danio rerio)	Actinopterygii	rnf111¹	ring finger protein 111	61.09(n) 62.26(a)		100151141 XM_001922673.3 XP_001922708.1
fruit fly (Drosophila melanogaster)	Insecta	CG6923⁶	--	15(a)	1 → many	3R(7570205-7575751)
worm (Caenorhabditis elegans)	Secernentea	toe-4⁶	Protein TOE-4	18(a)	1 → many	I(12738077-12741139)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G37580⁶	RING-H2 finger protein ATL33	17(a)	1 → many	2(15764728-15765553)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	zinc finger, C3HC4 type domain containing protein (see all 4)	26(a) 26(a) (see all 4)	many ↔ many many ↔ many (see all 4)	11(28262054-28262566) 11(28260929-28261441)

ENSEMBL Gene Tree for RNF111 (if available)
TreeFam Gene Tree for RNF111 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNF111 gene

RNF6² RNF11² RNF165² RNF38² RLIM² RNF44²

2 SIMAP similar genes for RNF111 using alignment to 5 protein entries: RN111_HUMAN (see all proteins):

LOC284996 RNF165

RNF111 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182475728^1,2		--	59278061(+)	`CGGAAA/GAGGAA`	3	--	us2k¹		0	--	--	--	--
rs114608812^1,2	F	--	59278334(+)	`AGTTTT/CCCCAC`	3	--	us2k¹		1		WA	118
rs66469077^1,2	C	--	59278383(+)	`TCATTTG/-TGTGT`	4	--	us2k¹		1		CSA	2
rs188048283^1,2		--	59278541(+)	`CCTCCC/GGAGTA`	4	--	us2k¹		0	--	--	--	--
rs192677179^1,2		--	59278565(+)	`GCGCCC/TGCCAC`	4	--	us2k¹		0	--	--	--	--
rs184021277^1,2		--	59278696(+)	`CAGGCA/GTGAGC`	4	--	us2k¹		0	--	--	--	--
rs72180031^1,2	C	--	59278899(+)	`AGTGG-/AGAAGGAG`	4	--	us2k¹		0	--	--	--	--
rs68017695^1,2	C	--	59278901(+)	`TGGAGAAG/-GAGTT`	4	--	us2k¹		1		NA	2
rs144416674^1,2	C	--	59278994(+)	`CAGGCA/GTGAGC`	4	--	us2k¹		0	--	--	--	--
rs115256142^1,2	F	--	59279039(+)	`TGATAC/TGGAAA`	4	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for RNF111 (59157374 - 59389618 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RNF111
2 CNVs: 58729 47963

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RNF111 for disorders           About GeneDecksing

OMIM gene information: 605840    OMIM disorders: --

5 diseases for RNF111:    About MalaCards

subclavian steal syndrome scrapie keratopathy colorectal cancer

fibrosis

Export disorders for RNF111 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RNF111 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with RNF111)

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Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. (PubMed id 17591695)^{1, 2} Levy L.... Hill C.S. (2007)
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. (PubMed id 16601693)^{1, 2} Liu W.... Lin S.-C. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7. (PubMed id 14657019)^{1, 2} Koinuma D.... Miyazono K. (2003)
Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. (PubMed id 11298452)^{1, 3} Episkopou V....Swan D. (2001)
Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)¹ Inouye M....de Bakker P.I. (2012)
NMR-based insights into the conformational and interac tion properties of Arkadia RING-H2 E3 Ub ligase. (PubMed id 22411132)¹ Chasapis C.T....Spyroulias G.A. (2012)
Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)¹ Woodsmith J....Sanderson C.M. (2012)
PolySUMO-binding proteins identified through a string search. (PubMed id 23086935)² Sun H. and Hunter T. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 54778	HGNC: 17384	AceView: RNF111	Ensembl:ENSG00000157450	euGenes: HUgn54778
ECgene: RNF111	H-InvDB: RNF111

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RNF111	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RNF111	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RNF111 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RNF111 gene:
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ring finger protein 111

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RNF111 Gene

ring finger protein 111

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