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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNF11 Gene

protein-coding   GIFtS: 49
GCID: GC01P051701

ring finger protein 11
 Explore 6 diseases affiliated with
RNF11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNF11    

Aliases
for RNF11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ring Finger Protein 111 2
CGI-1231
MGC511691
Sid1669p1
SID16692

External Ids:    HGNC: 100561   Entrez Gene: 269942   Ensembl: ENSG000001230917   OMIM: 6125985   UniProtKB: Q9Y3C53   

Export aliases for RNF11 gene to outside databases

Previous GC identifers: GC01P051328 GC01P050590 GC01P051061 GC01P051071 GC01P051413 GC01P051474 GC01P049819


Summaries
for RNF11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RNF11:
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein
interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The
germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5
Function: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that
ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after
TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of
'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or
LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading
to its degradation by the 26S proteasome

Gene Wiki entry for RNF11


Genomic Views
for RNF11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNF11 gene promoter:
         SRF   SRF (504 AA)   Egr-1   Lmo2   AP-2gamma   CREB   S8   deltaCREB   ZID   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF11 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNF11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32

RNF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P051701:  view genomic region     (about GC identifiers)

Start:
 51,701,943 bp from pter      End:
 51,739,127 bp from pter
Size:
 37,185 bases      Orientation:
 plus strand

Proteins
for RNF11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5 (See protein sequence)
Recommended Name: RING finger protein 11  
Size: 154 amino acids; 17444 Da
Subunit: Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and
WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with
CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP. After TNF stimulation, interacts with TAX1BP1,
TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By
similarity). Interacts with GGA1
Subcellular location: Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when
unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1 (PubMed:16123141)
Secondary accessions: A8KAI2 Q5T7R8

Explore the universe of human proteins at neXtProt for RNF11: NX_Q9Y3C5

Post-translational modifications:

  • Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP11
  • Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome1
  • May be acylated at Cys-4, possibly palmitoylated. Acylation at both Gly-2 and Cys-4 is required for proper localization
    • to the endosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y3C5

    • RNF11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055187.1  
    ENSEMBL proteins: 
     ENSP00000242719  

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    Uscn Proteins for RNF11

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA14755250
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005769early endosome IEA--
    GO:0055037recycling endosome IEA--


    RNF11 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for RNF11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNF11 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y3C5

    ProtoNet protein and cluster: Q9Y3C5

    1 Blocks protein family: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5
    Domain: The WW-binding motif mediates interaction with NEDD4 (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    Function
    for RNF11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5
    Function: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that
    ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after
    TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of
    'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or
    LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading
    to its degradation by the 26S proteasome

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: RNF11 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10673045
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--


    RNF11 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RNF11:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased cell death HMECs cel 


    Pathways & Interactions
    for RNF11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/94 Interacting proteins for RNF11 (Q9Y3C51, 2, 3 ENSP000002427194) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J021, 2, 3, ENSP000003639984EBI-2129167,EBI-1564678 MINT-8012832 MINT-8012809 MINT-8012823 MINT-8012755 I2D: score=6 STRING: ENSP00000363998
    UBE2D2P628371, 2, 3, ENSP000003817174EBI-2129167,EBI-347677 MINT-60866 I2D: score=6 STRING: ENSP00000381717
    UBE2NP610881, 2, 3, ENSP000003161764EBI-2129167,EBI-1052908 MINT-60857 I2D: score=5 STRING: ENSP00000316176
    UBBP0CG471, 3, ENSP000003046974EBI-2129167,EBI-413034 I2D: score=7 STRING: ENSP00000304697
    UBA52P629872, 3, ENSP000003881074MINT-60882 I2D: score=6 STRING: ENSP00000388107
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA14755250


    RNF11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNF11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNF11
    Search CenterWatch for drugs/clinical trials and news about RNF11 

    Transcripts
    for RNF11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNF11 gene: 
    NM_014372.4  

    Unigene Cluster for RNF11:

    Ring finger protein 11
    Hs.309641  [show with all ESTs]
    Unigene Representative Sequence: NM_014372
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242719(uc001csi.4) ENST00000494873 ENST00000486691

    miRNA
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    hsa-miR-582-3p hsa-miR-498 hsa-miR-3194-5p hsa-miR-218-2* hsa-miR-25 hsa-miR-3133 hsa-miR-29b-1* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: RNF11 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB024703.1 AF151881.1 AK293047.1 AK313140.1 AL049294.1 BC020964.2 BC036670.1 BC047654.1 

    12 DOTS entries:

    DT.456304  DT.100794446  DT.91988726  DT.91801048  DT.95213774  DT.121434903  DT.121434937  DT.91837319 
    DT.121434924  DT.92444668  DT.95122515  DT.95122516 

    24/333 AceView cDNA sequences (see all 333):

    H02233 AI351480 R82046 F03060 AA496311 AW675823 AI200551 BM832357 
    BQ084296 D55896 BI088410 BQ917992 R12081 AI277929 CK430429 AI375342 
    BQ878876 BC020964 AI360901 BQ694027 BQ436230 T36273 AI167368 BG170974 

    GeneLoc Exon Structure


    Expression
    for RNF11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATCTTGCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RNF11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNF11

    SOURCE GeneReport for Unigene cluster: Hs.309641

    UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5
    Tissue specificity: Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary,
    small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and
    placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions:
    high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in
    the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded
    from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and
    nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed
    in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial
    cells (at protein level). Also expressed in several tumor cell lines

        SABiosciences Expression via Pathway-Focused PCR Array including RNF11: 
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    In Situ
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    Orthologs
    for RNF11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNF11 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RNF111 ring finger protein 11 85.5(n)
    97.4(a)    		   424631  NM_001006540.1  NP_001006540.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RNF116
    		 --
    		 99(a)
    		 1 ↔ 1
    		 4(113909402-113942333)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC043736.12   -- 82.7(n)    BC043736.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc638612 similar to ring finger protein 11 75.18(n)   393996  BC053118.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG328501 CG32850 58.16(n)
    60.99(a)    		   318246  NM_166753.2  NP_726563.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_C01G6.41 Protein C01G6.4 49.3(n)
    40.14(a)    		   182077  NM_063575.3  NP_495976.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G172456
    AT1G530106
    (see all 15)    		 putative RING-H2 finger protein ATL19
    (see all 15)    		 20(a)
    19(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 4(9669365-9670005)
    1(19747847-19748383)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 16)    		 RING-H2 finger protein, putative, expressed
    (see all 16)    		 9(a)
    7(a)
    (see all 16)    		 many ↔ many
    many ↔ many
    (see all 16)    		 10(20983611-20984998)
    4(20561343-20563983)


    ENSEMBL Gene Tree for RNF11 (if available)
    TreeFam Gene Tree for RNF11 (if available) 

    Paralogs
    for RNF11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNF11 gene
    RNF62  RNF1652  RNF382  RLIM2  RNF442  RNF1112  

    RNF11 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RNF11
    PGOHUM00000247448 PGOHUM00000240461 PGOHUM00000249531


    Genomic Variants
    for RNF11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/644 NCBI SNPs in RNF11 are shown (see all 644)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1481498311,2
    		--51699949(+) TTCTT-/TTTC  
                TTTCT     		1 -- us2k10--------
    rs108887191,2
    		C,A,H--51699957(+) TCTTTC/TTCTTT 1 -- us2k1 trp30--------
    rs108887201,2
    		C,A,H--51699959(+) TTTTTC/TTTTCT 1 -- us2k1 trp30--------
    rs1996987301,2
    		--51699964(+) CTTTC-/TTTCTTT 1 -- us2k10--------
    rs1434940131,2
    		--51699996(+) TCTTTA/CTTTTC 1 -- us2k10--------
    rs125648701,2
    		H--51700000(+) tctttC/Tctttc 1 -- us2k1 trp30--------
    rs125676271,2
    		H--51700001(+) cttttC/Ttttct 1 -- us2k1 trp30--------
    rs2012945531,2
    		--51700004(+) TTCTT-/TCTCTTT 1 -- us2k10--------
    rs1831708661,2
    		--51700031(+) CTCCCC/TTCCTT 1 -- us2k10--------
    rs125648811,2
    		H--51700032(+) tccctC/Tccttc 1 -- us2k1 trp30--------

    HapMap Linkage Disequilibrium report for RNF11 (51701943 - 51739127 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RNF11: --

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    Disorders / Diseases
    for RNF11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNF11 for disorders           About GeneDecksing

    OMIM gene information: 612598    OMIM disorders: --

    6 diseases for RNF11:    About MalaCards
    multiple endocrine neoplasia    corpus callosum    parkinson's disease    breast cancer
    prostatitis    neuronitis


    Export disorders for RNF11 gene to outside databases

    Publications
    for RNF11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNF11 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with RNF11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein. (PubMed id 10673045)1, 2, 3, 9 Seki N.... Saito T. (1999)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. (PubMed id 17917589)1, 2, 9 Anderson L.R....Levey A.I. (2007)
    4. The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. (PubMed id 14562029)1, 2, 9 Subramaniam V....Seth A. (2003)
    5. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PubMed id 18724389)1, 2, 9 Chen C.... Seth A.K. (2008)
    6. Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartmen t. (PubMed id 20676133)1, 2 Santonico E....Castagnoli L. (2010)
    7. The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF- kappaB signalling. (PubMed id 19131965)1, 2 Shembade N.... Harhaj E.W. (2009)
    8. Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes. (PubMed id 18615712)1, 2 Scheper J....Thomson T.M. (2009)
    9. Molecular characterization of ring finger protein 11. (PubMed id 16123141)1, 2 Connor M.K.... Seth A.K. (2005)
    10. An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. (PubMed id 14755250)1, 2 Li H. and Seth A. (2004)

    External Searches for RNF11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    Genome Databases showing RNF11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26994 HGNC: 10056 AceView: RNF11 Ensembl:ENSG00000123091 euGenes: HUgn26994
    ECgene: RNF11 H-InvDB: RNF11

    Other Databases showing RNF11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNF11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNF11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNF11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNF11 gene:
    Search GeneIP for patents involving RNF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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