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Aliases for RNF11 Gene

Aliases for RNF11 Gene

  • Ring Finger Protein 11 2 3 5
  • CGI-123 3
  • SID1669 3

External Ids for RNF11 Gene

Previous GeneCards Identifiers for RNF11 Gene

  • GC01P051328
  • GC01P050590
  • GC01P051061
  • GC01P051071
  • GC01P051413
  • GC01P051474
  • GC01P051701
  • GC01P049819

Summaries for RNF11 Gene

Entrez Gene Summary for RNF11 Gene

  • The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF11 Gene

RNF11 (Ring Finger Protein 11) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF11 Gene

  • Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates Lys-63 polyubiquitin chains on RIPK1 and catalyzes the formation of Lys-48-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Gene Wiki entry for RNF11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF11 Gene

Genomics for RNF11 Gene

Regulatory Elements for RNF11 Gene

Enhancers for RNF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G051234 1.7 FANTOM5 ENCODE dbSUPER 13.7 +0.3 283 4.3 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 YY1 RNF11 LINC01562 OSBPL9 RPS2P8
GH01G051267 1.2 Ensembl ENCODE 11.7 +32.0 32043 2.6 HDGF FOXA2 BMI1 GATA2 ZNF366 FOS HMG20B ZNF174 JUNB ZEB2 LINC01562 RNF11 CDKN2C RPS2P8 ENSG00000236434 GC01P051287
GH01G051263 1.4 Ensembl ENCODE 5.2 +28.3 28287 2.9 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 CBX5 ZNF143 ZNF207 LINC01562 RNF11 ENSG00000236434 RPS2P8
GH01G051240 0.9 Ensembl ENCODE 0.7 +4.0 4030 0.6 NFIC NFIA ZBTB48 ZNF366 ZNF600 HNF4A PRDM1 YY1 RNF11 RPS2P8
GH01G051241 0.5 Ensembl 0.7 +4.9 4930 0.4 OSR2 ZNF121 PRDM6 RNF11 RPS2P8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF11 on UCSC Golden Path with GeneCards custom track

Promoters for RNF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000006264 929 2801 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 KLF13 SP3

Genomic Location for RNF11 Gene

Chromosome:
1
Start:
51,236,271 bp from pter
End:
51,273,455 bp from pter
Size:
37,185 bases
Orientation:
Plus strand

Genomic View for RNF11 Gene

Genes around RNF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF11 Gene

Proteins for RNF11 Gene

  • Protein details for RNF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C5-RNF11_HUMAN
    Recommended name:
    RING finger protein 11
    Protein Accession:
    Q9Y3C5
    Secondary Accessions:
    • A8KAI2
    • Q5T7R8

    Protein attributes for RNF11 Gene

    Size:
    154 amino acids
    Molecular mass:
    17444 Da
    Quaternary structure:
    • Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP. After TNF stimulation, interacts with TAX1BP1, TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with GGA1.

neXtProt entry for RNF11 Gene

Post-translational modifications for RNF11 Gene

  • Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes.
  • Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome.
  • Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF11 Gene

Domains & Families for RNF11 Gene

Gene Families for RNF11 Gene

Protein Domains for RNF11 Gene

Suggested Antigen Peptide Sequences for RNF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3C5

UniProtKB/Swiss-Prot:

RNF11_HUMAN :
  • The WW-binding motif mediates interaction with NEDD4.
Domain:
  • The WW-binding motif mediates interaction with NEDD4.
genes like me logo Genes that share domains with RNF11: view

Function for RNF11 Gene

Molecular function for RNF11 Gene

UniProtKB/Swiss-Prot Function:
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates Lys-63 polyubiquitin chains on RIPK1 and catalyzes the formation of Lys-48-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Gene Ontology (GO) - Molecular Function for RNF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10673045
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 14755250
GO:0008270 zinc ion binding TAS 10673045
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF11: view
genes like me logo Genes that share phenotypes with RNF11: view

Animal Model Products

CRISPR Products

miRNA for RNF11 Gene

miRTarBase miRNAs that target RNF11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF11 Gene

Localization for RNF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF11 Gene

Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000269 PubMed:16123141}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF11 gene
Compartment Confidence
extracellular 5
nucleus 5
endosome 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RNF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 14755250
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with RNF11: view

Pathways & Interactions for RNF11 Gene

SuperPathways for RNF11 Gene

No Data Available

SIGNOR curated interactions for RNF11 Gene

Activates:

Gene Ontology (GO) - Biological Process for RNF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 14755250
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF11: view

No data available for Pathways by source for RNF11 Gene

Transcripts for RNF11 Gene

mRNA/cDNA for RNF11 Gene

Unigene Clusters for RNF11 Gene

Ring finger protein 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF11 Gene

No ASD Table

Relevant External Links for RNF11 Gene

GeneLoc Exon Structure for
RNF11
ECgene alternative splicing isoforms for
RNF11

Expression for RNF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF11 Gene

This gene is overexpressed in Bone (50.5) and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF11 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNF11 Gene:

RNF11

SOURCE GeneReport for Unigene cluster for RNF11 Gene:

Hs.309641

mRNA Expression by UniProt/SwissProt for RNF11 Gene:

Q9Y3C5-RNF11_HUMAN
Tissue specificity: Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines.

Evidence on tissue expression from TISSUES for RNF11 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with RNF11: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF11 Gene

Orthologs for RNF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF11 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF11 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF11 34 35
  • 97.62 (n)
mouse
(Mus musculus)
Mammalia Rnf11 34 16 35
  • 96.97 (n)
rat
(Rattus norvegicus)
Mammalia Rnf11l1 34
  • 95.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RNF11 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF11 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF11 34 35
  • 85.5 (n)
lizard
(Anolis carolinensis)
Reptilia RNF11 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf11 34
  • 83.33 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf11b 34 35
  • 77.71 (n)
zgc63861 34
fruit fly
(Drosophila melanogaster)
Insecta CG32850 34 35
  • 54.25 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C01G6.4 34
  • 49.3 (n)
C01G6.4 35
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for RNF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF11 Gene

ENSEMBL:
Gene Tree for RNF11 (if available)
TreeFam:
Gene Tree for RNF11 (if available)

Paralogs for RNF11 Gene

Pseudogenes.org Pseudogenes for RNF11 Gene

genes like me logo Genes that share paralogs with RNF11: view

No data available for Paralogs for RNF11 Gene

Variants for RNF11 Gene

Sequence variations from dbSNP and Humsavar for RNF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000118742 -- 51,255,605(+) TTAAT(A/C)CTGAT intron-variant
rs1000189442 -- 51,256,855(+) TTTTA(C/G)TAGAG intron-variant
rs1000198532 -- 51,252,164(+) ATTTT(C/G)CTAAT intron-variant
rs1000238762 -- 51,255,351(+) AAACT(C/G)TGGGC intron-variant
rs1000697467 -- 51,265,084(+) CACTT(G/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF11 Gene

Variant ID Type Subtype PubMed ID
esv2663443 CNV deletion 23128226
esv3586031 CNV loss 21293372
esv3586032 CNV loss 21293372
nsv945940 CNV duplication 23825009

Variation tolerance for RNF11 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF11 Gene

Disorders for RNF11 Gene

Relevant External Links for RNF11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF11

No disorders were found for RNF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF11 Gene

Publications for RNF11 Gene

  1. Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein. (PMID: 10673045) Seki N. … Saito T. (Biochim. Biophys. Acta 1999) 2 3 4 22 64
  2. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PMID: 18724389) Chen C. … Seth A.K. (Oncogene 2008) 3 4 22 64
  3. PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. (PMID: 17917589) Anderson L.R. … Levey A.I. (J. Neuropathol. Exp. Neurol. 2007) 3 4 22 64
  4. The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. (PMID: 14562029) Subramaniam V. … Seth A.K. (Br. J. Cancer 2003) 3 4 22 64
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64

Products for RNF11 Gene

Sources for RNF11 Gene

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