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RNF11 Gene

protein-coding   GIFtS: 51
GCID: GC01P051701

Ring Finger Protein 11

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 111 2
SID16692

External Ids:    HGNC: 100561   Entrez Gene: 269942   Ensembl: ENSG000001230917   OMIM: 6125985   UniProtKB: Q9Y3C53   

Export aliases for RNF11 gene to outside databases

Previous GC identifers: GC01P051328 GC01P050590 GC01P051061 GC01P051071 GC01P051413 GC01P051474 GC01P049819


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF11 Gene:
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for
protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins
(MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple
endocrine neoplasia (MEN). (provided by RefSeq, Jul 2008)

GeneCards Summary for RNF11 Gene:
RNF11 (ring finger protein 11) is a protein-coding gene. Diseases associated with RNF11 include multiple endocrine neoplasia, and cystic fibrosis.

UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5
Function: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1,
that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to
RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the
formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently
termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase
SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome

Gene Wiki entry for RNF11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF11 gene promoter:
         SRF   SRF (504 AA)   Egr-1   Lmo2   AP-2gamma   CREB   S8   deltaCREB   ZID   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF11 promoter sequence
   Search Chromatin IP Primers for RNF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p32.3   HGNC cytogenetic band: 1p32

RNF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P051701:  view genomic region     (about GC identifiers)

Start:
51,701,943 bp from pter      End:
51,739,127 bp from pter
Size:
37,185 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5 (See protein sequence)
Recommended Name: RING finger protein 11  
Size: 154 amino acids; 17444 Da
Subunit: Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2
and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither
with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP. After TNF stimulation, interacts with
TAX1BP1, TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with
TNF (By similarity). Interacts with GGA1
Secondary accessions: A8KAI2 Q5T7R8

Explore the universe of human proteins at neXtProt for RNF11: NX_Q9Y3C5

Explore proteomics data for RNF11 at MOPED

Post-translational modifications: 

  • Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP11
  • Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome1
  • May be acylated at Cys-4, possibly palmitoylated. Acylation at both Gly-2 and Cys-4 is required for proper
    localization to the endosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055187.1  
    ENSEMBL proteins: 
     ENSP00000242719  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y3C5

    ProtoNet protein and cluster: Q9Y3C5

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5
    Domain: The WW-binding motif mediates interaction with NEDD4 (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    RNF11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF11_HUMAN, Q9Y3C5
    Function: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1,
    that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to
    RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the
    formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently
    termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase
    SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS10673045
    GO:0005515protein binding IPI14755250
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RNF11 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNF11:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF11
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    miRNA
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    miRTarBase miRNAs that target RNF11:
    hsa-mir-340-5p (MIRT019648), hsa-mir-21-5p (MIRT031075), hsa-mir-24-3p (MIRT030623), hsa-mir-19b-3p (MIRT031299), hsa-mir-484 (MIRT042387)

    Block miRNA regulation of human, mouse, rat RNF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF11 (see all 26):
    hsa-miR-582-3p hsa-miR-498 hsa-miR-3194-5p hsa-miR-218-2* hsa-miR-25 hsa-miR-3133 hsa-miR-29b-1* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRNF11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNF11

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    GenScript: all cDNA clones in your preferred vector: RNF11 (NM_007148)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF11_HUMAN, Q9Y3C5: Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when
    unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1 (PubMed:16123141)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA14755250
    GO:0005634nucleus IEA--
    GO:0005769early endosome IEA--
    GO:0055037recycling endosome IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    RNF11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNF11: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF11 (Q9Y3C51, 2, 3 ENSP000002427194) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITCHQ96J021, 2, 3, ENSP000003639984EBI-396669,EBI-1564678 MINT-8012832 MINT-8012809 MINT-8012823 MINT-8012755 I2D: score=6 STRING: ENSP00000363998
    UBE2D2P628371, 2, 3, ENSP000003817174EBI-396669,EBI-347677 MINT-60866 I2D: score=6 STRING: ENSP00000381717
    UBE2NP610881, 2, 3, ENSP000003161764EBI-396669,EBI-1052908 MINT-60857 I2D: score=5 STRING: ENSP00000316176
    UBBP0CG471, 3, ENSP000003046974EBI-396669,EBI-413034 I2D: score=7 STRING: ENSP00000304697
    UBA52P629872, 3, ENSP000003881074MINT-60882 I2D: score=6 STRING: ENSP00000388107
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA14755250

    RNF11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF11 gene: 
    NM_014372.4  

    Unigene Cluster for RNF11:

    Ring finger protein 11
    Hs.309641  [show with all ESTs]
    Unigene Representative Sequence: NM_014372
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000242719(uc001csi.4) ENST00000494873 ENST00000486691

    miRNA
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    Block miRNA regulation of human, mouse, rat RNF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF11 (see all 26):
    hsa-miR-582-3p hsa-miR-498 hsa-miR-3194-5p hsa-miR-218-2* hsa-miR-25 hsa-miR-3133 hsa-miR-29b-1* hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidRNF11 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RNF11
      QuantiFast Probe-based Assays in human, mouse, rat RNF11

    Additional mRNA sequence: 

    AB024703.1 AF151881.1 AK293047.1 AK313140.1 AL049294.1 BC020964.2 BC036670.1 BC047654.1 

    12 DOTS entries:

    DT.456304  DT.100794446  DT.91988726  DT.91801048  DT.95213774  DT.121434903  DT.121434937  DT.91837319 
    DT.121434924  DT.92444668  DT.95122515  DT.95122516 

    Selected AceView cDNA sequences (see all 333):

    AJ714197 R82046 Z39860 AI004824 AI360901 AI351480 BQ084296 BQ231674 
    C16877 BE856243 AA452386 AI873795 AI277929 BQ917992 F03060 AA342322 
    BM769900 BU171163 AW675823 BQ694027 T36273 AA424581 BQ695122 AI052699 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTTGCTT
    RNF11 Expression
    About this image


    RNF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
    RNF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.309641

    UniProtKB/Swiss-Prot: RNF11_HUMAN, Q9Y3C5
    Tissue specificity: Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary,
    small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart,
    brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in
    several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and
    extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in
    somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in
    cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease,
    sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the
    surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in
    several tumor cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including RNF11: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNF11 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf111 , 5 ring finger protein 111, 5 96.97(n)1
    99.35(a)1
      4 (51.29 cM)5
    298641  NM_013876.31  NP_038904.11 
     1094510985 
    chicken
    (Gallus gallus)
    Aves RNF111 ring finger protein 11 85.5(n)
    97.4(a)
      424631  NM_001006540.1  NP_001006540.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNF116
    ring finger protein 11
    99(a)
    1 ↔ 1
    4(113909400-113942346)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043736.12   -- 82.7(n)    BC043736.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638612 similar to ring finger protein 11 75.18(n)   393996  BC053118.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG328501 CG32850 54.25(n)
    56.55(a)
      318246  NM_001272124.1  NP_001259053.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_C01G6.41 CELE_C01G6.4 49.3(n)
    40.14(a)
      182077  NM_063575.4  NP_495976.1 


    ENSEMBL Gene Tree for RNF11 (if available)
    TreeFam Gene Tree for RNF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF11 gene

    RNF11 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RNF11
    PGOHUM00000247448 PGOHUM00000240461 PGOHUM00000249531


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF11 (see all 769)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481498311,2
    C--51699949(+) TTCTT-/TTTC  
            
    TTTCT
    1 -- us2k10--------
    rs717240051,2
    C--51699950(+) TCTTT-/TTTC  
            
    TTCTT
    1 -- us2k10--------
    rs108887191,2
    C,A,H--51699957(+) tctttC/Ttcttt 1 -- us2k1 trp30--------
    rs108887201,2
    C,A,H--51699959(+) tttttC/Ttttct 1 -- us2k1 trp30--------
    rs1996987301,2
    --51699964(+) CTTTC-/TTTCTTT 1 -- us2k10--------
    rs1123798481,2
    C--51699980(+) CTTTC-/TTTTCT 1 -- us2k11Minor allele frequency- T:0.00CSA 2
    rs1434940131,2
    --51699996(+) TCTTTA/CTTTTC 1 -- us2k10--------
    rs125648701,2
    H--51700000(+) tctttC/Tctttc 1 -- us2k1 trp30--------
    rs125676271,2
    H--51700001(+) cttttC/Ttttct 1 -- us2k1 trp30--------
    rs2012945531,2
    --51700004(+) TTCTT-/TCTCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNF11 (51701943 - 51739127 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RNF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663443CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF11
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612598    OMIM disorders: --

    7 diseases for RNF11:    
    About MalaCards
    multiple endocrine neoplasia    cystic fibrosis    parkinson's disease    breast cancer
    neuronitis    cerebritis    prostatitis


    RNF11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for RNF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF11 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with RNF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein. (PubMed id 10673045)1, 2, 3, 9 Seki N.... Saito T. (Biochim. Biophys. Acta 1999)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    3. PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. (PubMed id 17917589)1, 2, 9 Anderson L.R.... Levey A.I. (J. Neuropathol. Exp. Neurol. 2007)
    4. The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. (PubMed id 14562029)1, 2, 9 Subramaniam V.... Seth A.K. (Br. J. Cancer 2003)
    5. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PubMed id 18724389)1, 2, 9 Chen C.... Seth A.K. (Oncogene 2008)
    6. Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment. (PubMed id 20676133)1, 2 Santonico E....Castagnoli L. (Oncogene 2010)
    7. The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF- kappaB signalling. (PubMed id 19131965)1, 2 Shembade N.... Harhaj E.W. (EMBO J. 2009)
    8. Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes. (PubMed id 18615712)1, 2 Scheper J.... Thomson T.M. (Proteins 2009)
    9. Molecular characterization of ring finger protein 11. (PubMed id 16123141)1, 2 Connor M.K.... Seth A.K. (Mol. Cancer Res. 2005)
    10. An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. (PubMed id 14755250)1, 2 Li H. and Seth A.K. (Oncogene 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26994 HGNC: 10056 AceView: RNF11 Ensembl:ENSG00000123091 euGenes: HUgn26994
    ECgene: RNF11 H-InvDB: RNF11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RNF11 gene:
    Search GeneIP for patents involving RNF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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