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Aliases for RNF103-CHMP3 Gene

Aliases for RNF103-CHMP3 Gene

  • RNF103-CHMP3 Readthrough 2 3 5
  • RNF103-VPS24 Readthrough 2 3
  • RNF103-CHMP3 Read-Through 3
  • RNF103-CHMP3 Protein 3
  • RNF103-VPS24 3

External Ids for RNF103-CHMP3 Gene

Previous HGNC Symbols for RNF103-CHMP3 Gene

  • RNF103-VPS24

Previous GeneCards Identifiers for RNF103-CHMP3 Gene

  • GC02M086738

Summaries for RNF103-CHMP3 Gene

Entrez Gene Summary for RNF103-CHMP3 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Oct 2011]

GeneCards Summary for RNF103-CHMP3 Gene

RNF103-CHMP3 (RNF103-CHMP3 Readthrough) is a Protein Coding gene. Among its related pathways are Internalization of ErbB1 and Endocytosis. An important paralog of this gene is CHMP3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF103-CHMP3 Gene

Genomics for RNF103-CHMP3 Gene

Regulatory Elements for RNF103-CHMP3 Gene

Enhancers for RNF103-CHMP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F086747 0.4 ENCODE 11.9 -27.1 -27053 1.5 BMI1 CEBPG IRF9 TRIM24 RFX1 ZNF740 HLF CEBPB EP300 POLR2H RNF103-CHMP3 RNF103 CHMP3 RNU6-640P CD8A RMND5A IMMT GC02M086689 LOC105374846
GH02F086671 0.8 Ensembl ENCODE 11.9 +49.6 49598 0.6 SOX13 ATF1 JUN RAD21 GATA3 GATA2 GATAD2A NFIA CEBPB NR3C1 RNF103 RNF103-CHMP3 CHMP3 RNU6-640P GC02P086686
GH02F086583 1.3 Ensembl ENCODE 11.8 +136.8 136834 1.4 HDAC1 TBL1XR1 GATA2 ELF1 MEF2D SMARCA4 PBX2 IKZF1 HMBOX1 FOXJ2 RNF103 RNF103-CHMP3 GC02M086575 CHMP3
GH02F086694 1.1 FANTOM5 ENCODE 10.9 +25.7 25727 1.5 ELF3 CBX3 INSM2 GLI4 DNMT3B RARA CHAMP1 ZNF155 ZNF366 SCRT2 SNORD94 LOC102724642 RNF103-CHMP3 RNF103 CHMP3 RNU6-640P RMND5A CD8A ENSG00000231259 GC02P086686
GH02F086697 0.2 Ensembl 10.9 +23.4 23422 0.6 RNF103-CHMP3 RNF103 GC02P086686 RMND5A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RNF103-CHMP3 on UCSC Golden Path with GeneCards custom track

Promoters for RNF103-CHMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001544188 422 3401 ATF1 PKNOX1 INSM2 SIN3A ZBTB40 CHAMP1 GLIS2 SCRT2 ZNF207 EGR2
ENSR00001824709 -1778 201

Genomic Location for RNF103-CHMP3 Gene

86,503,430 bp from pter
86,721,122 bp from pter
217,693 bases
Minus strand

Genomic View for RNF103-CHMP3 Gene

Genes around RNF103-CHMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF103-CHMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF103-CHMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF103-CHMP3 Gene

Proteins for RNF103-CHMP3 Gene

  • Protein details for RNF103-CHMP3 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein RNF103-CHMP3
    Protein Accession:

    Protein attributes for RNF103-CHMP3 Gene

    221 amino acids
    Molecular mass:
    25416 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF103-CHMP3 Gene

Post-translational modifications for RNF103-CHMP3 Gene

No Post-translational modifications

Other Protein References for RNF103-CHMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF103-CHMP3 Gene

Domains & Families for RNF103-CHMP3 Gene

Protein Domains for RNF103-CHMP3 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF103-CHMP3: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNF103-CHMP3 Gene

Function for RNF103-CHMP3 Gene

Phenotypes for RNF103-CHMP3 Gene

GenomeRNAi human phenotypes for RNF103-CHMP3:
genes like me logo Genes that share phenotypes with RNF103-CHMP3: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF103-CHMP3 Gene

Localization for RNF103-CHMP3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RNF103-CHMP3 Gene

Pathways & Interactions for RNF103-CHMP3 Gene

SuperPathways for RNF103-CHMP3 Gene

genes like me logo Genes that share pathways with RNF103-CHMP3: view

Pathways by source for RNF103-CHMP3 Gene

1 BioSystems pathway for RNF103-CHMP3 Gene
1 KEGG pathway for RNF103-CHMP3 Gene

Gene Ontology (GO) - Biological Process for RNF103-CHMP3 Gene


No data available for SIGNOR curated interactions for RNF103-CHMP3 Gene

Transcripts for RNF103-CHMP3 Gene

mRNA/cDNA for RNF103-CHMP3 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNF103-CHMP3 Gene

No ASD Table

Relevant External Links for RNF103-CHMP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF103-CHMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF103-CHMP3 Gene

genes like me logo Genes that share expression patterns with RNF103-CHMP3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RNF103-CHMP3 Gene

Orthologs for RNF103-CHMP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF103-CHMP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
(Mus musculus)
Mammalia Chmp3 35
  • 90 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
(Bos Taurus)
Mammalia -- 35
  • 71 (a)
(Canis familiaris)
Mammalia -- 35
  • 70 (a)
(Gallus gallus)
Aves -- 35
  • 87 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
(Danio rerio)
Actinopterygii chmp3 35
  • 79 (a)
fruit fly
(Drosophila melanogaster)
Insecta vps24 35
  • 57 (a)
(Caenorhabditis elegans)
Secernentea vps-24 35
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS24 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
Species where no ortholog for RNF103-CHMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF103-CHMP3 Gene

Gene Tree for RNF103-CHMP3 (if available)
Gene Tree for RNF103-CHMP3 (if available)

Paralogs for RNF103-CHMP3 Gene

Paralogs for RNF103-CHMP3 Gene

genes like me logo Genes that share paralogs with RNF103-CHMP3: view

Variants for RNF103-CHMP3 Gene

Sequence variations from dbSNP and Humsavar for RNF103-CHMP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1003207 -- 86,588,232(+) AAAAA(A/T)AGTTC intron-variant
rs1003208 -- 86,588,263(+) ATCTA(A/G)TATAA intron-variant
rs1015117 -- 86,513,740(-) ATCTT(G/T)AATGC intron-variant
rs10165616 -- 86,571,221(+) agtat(C/T)tgata intron-variant
rs10165856 -- 86,696,636(+) ttttt(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF103-CHMP3 Gene

Variant ID Type Subtype PubMed ID
esv1297314 CNV deletion 17803354
esv1775646 CNV insertion 17803354
esv2625579 CNV deletion 19546169
esv2639295 CNV deletion 19546169
esv2720302 CNV deletion 23290073
esv3591550 CNV loss 21293372
esv3591551 CNV loss 21293372
esv3591552 CNV loss 21293372
esv3591554 CNV loss 21293372
esv3591555 CNV loss 21293372
esv3591556 CNV loss 21293372
nsv10063 CNV gain 18304495
nsv1011590 CNV gain 25217958
nsv1072419 CNV deletion 25765185
nsv1115563 CNV duplication 24896259
nsv2813 CNV insertion 18451855
nsv2814 CNV insertion 18451855
nsv436305 CNV deletion 17901297
nsv818064 CNV loss 17921354
nsv829488 CNV gain 20364138
nsv829489 CNV loss 20364138
nsv955217 CNV duplication 24416366
nsv961802 CNV duplication 23825009

Variation tolerance for RNF103-CHMP3 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF103-CHMP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF103-CHMP3 Gene

Disorders for RNF103-CHMP3 Gene

Relevant External Links for RNF103-CHMP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNF103-CHMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF103-CHMP3 Gene

Publications for RNF103-CHMP3 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  2. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3 64
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64

Products for RNF103-CHMP3 Gene

Sources for RNF103-CHMP3 Gene

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