RNF103 Gene
protein-coding GIFtS: 45
GCID: GC02M086830
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ring finger protein 103(Previous name: zinc finger protein 103 homolog (mouse) ) (Previous symbol: ZFP103)
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Aliases for RNF103 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ring Finger Protein 1031 2 3 | | HKF-12 | | ZFP1031 2 3 5 | | ZFP-1032 | | KF11 2 5 | | E3 Ubiquitin-Protein Ligase RNF1032 | | Zinc Finger Protein 103 Homolog2 3 | | Zinc Finger Protein Expressed In Cerebellum2 | | KF-12 3 | | EC 6.3.2.-3 | | Hkf-11 | | Zfp-1033 | | Zinc Finger Protein 103 Homolog (Mouse)1 | | HKF-12 |
Export aliases for RNF103 gene to outside databasesPrevious GC identifers: GC02M086788 GC02M086805 GC02M086742 GC02M086584 GC02M086684 |
Summaries for RNF103 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for RNF103: The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein andprotein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. Theexpression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsivetreatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target forECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associateddegradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-throughtranscription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene.(provided by RefSeq, Oct 2011) UniProtKB/Swiss-Prot: RN103_HUMAN, O00237Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated proteindegradation pathway
|
Genomic Views for RNF103 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RNF103 gene promoter: AML1a HTF E4BP4 YY1 GATA-1 AREB6 HFH-1 SEF-1 (1) Other transcription factors
Search SABiosciences Chromatin IP Primers for RNF103
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNF103 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2RNF103 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M086830: view genomic region
(about GC identifiers)
Start:
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86,830,516 bp from pter |
End:
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86,850,989 bp from pter |
Size:
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20,474 bases |
Orientation:
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minus strand |
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Proteins for RNF103 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RN103_HUMAN, O00237 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase RNF103 Size: 685 amino acids; 79405 Da
Subunit: Interacts with DERL1 and VCP
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: A6NFV6 Q53SU6 Q8IVB9Explore the universe of human proteins at neXtProt for RNF103: NX_O00237
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00237 RNF103 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001185880.1 NP_001185881.1 NP_005658.1 ENSEMBL proteins: ENSP00000237455 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RNF103 for ontologies About GeneDecksing
RNF103 Antibody Products: Assay Products for RNF103: |
Protein
Domains / Families for RNF103 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNF103 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00237ProtoNet protein and cluster: O00237 1 Blocks protein family: IPB001841 Zn-finger
UniProtKB/Swiss-Prot: RN103_HUMAN, O00237Similarity: Contains 1 RING-type zinc finger |
Function for RNF103 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RN103_HUMAN, O00237Function: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated proteindegradation pathwayEnzyme Number (IUBMB): EC 6.3.2.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF103 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF103 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for RNF103 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF103  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF103 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RNF103 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for RNF103: Animal Models: Mouse knock-out Rnf103tm1.1Thg for RNF103 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rnf103):
RNF103 for phenotypes About GeneDecksing
|
Pathways & Interactions for RNF103 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: RN103_HUMAN, O00237Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNF103
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
 5/12 Interacting proteins for RNF103 (O002373 ENSP000002374554) via UniProtKB, MINT, STRING, and/or I2D (see all 12) About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
RNF103 for ontologies About GeneDecksing
|
Drugs & Compounds for RNF103 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RNF103 Search CenterWatch for drugs/clinical trials and news about RNF103 / RN103 
|
Transcripts for RNF103 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RNF103 gene (3 alternative transcripts): NM_001198951.1 NM_001198952.1 NM_005667.3 Unigene Cluster for RNF103: Ring finger protein 103 Hs.733319 [show with all ESTs]Unigene Representative Sequence: NM_0056676 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000237455(uc021vkg.1 uc002srn.3) ENST00000472030(uc002srm.3) ENST00000463333 ENST00000477307 ENST00000465629(uc002srp.3) ENST00000472680
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNF103 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNF103 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): RNF103 (NM_001198951) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNF103 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF103  |
Additional cDNA sequence: AK314180.1 BC022477.1 BC035053.2 BC110333.1 D76444.1 11 DOTS entries: DT.317273 DT.100688843 DT.99970935 DT.92428939 DT.95166340 DT.120975319 DT.120975329 DT.100660332 DT.114628 DT.317275 DT.95166332 24/686 AceView cDNA sequences (see all 686): BQ016899 BX503178 AI279015 AI866298 AA195697 AI658559 F37077 AA505885 BU071228 BQ876326 BU844532 N64402 BI438736 AI765285 BF432290 AI978665 BQ072163 BU158476 AJ710153 BM558031 BQ951446 AA976409 AI914828 AA668612 GeneLoc Exon Structure
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Expression for RNF103 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNF103 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See RNF103 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RNF103
SOURCE GeneReport for Unigene cluster: Hs.733319 UniProtKB/Swiss-Prot: RN103_HUMAN, O00237Tissue specificity: Highly expressed in the normal cerebellum but not in the cerebral cortex SABiosciences Expression via Pathway-Focused PCR Array including RNF103:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNF103 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNF103 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNF103 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNF103 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF103 |
Orthologs for RNF103 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNF103 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Rnf1031 , 5 |
ring finger protein 1031, 5 |
92.73(n)1 95.75(a)1 |
  |
6 (32.16 cM)5 226441 NM_009543.21 NP_033569.21 714938945 |
chicken (Gallus gallus) |
Aves |
RNF1031 |
ring finger protein 103 |
80.87(n) 87.41(a) |
  |
422919 NM_001031169.1 NP_001026340.1 |
lizard (Anolis carolinensis) |
Reptilia |
RNF1036 |
-- |
88(a) |
1 ↔ 1 |
6(60521584-60537007) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.174372 |
Xenopus laevis x-kf-1b mRNA for KF-1b, complete cds |
77.53(n) |
  |
AB083247.1 |
zebrafish (Danio rerio) |
Actinopterygii |
BI876087.12 |
-- |
77.88(n) |
  |
BI876087.1 |
ENSEMBL Gene Tree for RNF103 (if available) TreeFam Gene Tree for RNF103 (if available)  |
Paralogs for RNF103 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RNF103 gene
- RNF103-CHMP32
RNF103 for paralogs About GeneDecksing
|
Genomic Variants for RNF103 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for RNF103 (86830516 - 86850989 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RNF103 1 CNV: 22520  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for RNF103 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNF103 for disorders About GeneDecksing
OMIM gene information: 602507
OMIM disorders: --
6 diseases for RNF103: About MalaCardscerebritis serous cystadenocarcinoma epidermolysis bullosa herpes gestationis bullous pemphigoid cystadenocarcinoma Export disorders for RNF103 gene to outside databases
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Publications for RNF103 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNF103 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with RNF103) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. (PubMed id 9070305)1, 2, 3, 9 Yasojima K.... Hashimoto-Gotoh T. (1997)
- Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway. (PubMed id 18675248)1, 2 Maruyama Y....Yamada M. (2008)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)1, 2 Lorick K.L....Weissman A.M. (1999)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes. (PubMed id 18615712)1 Scheper J....Thomson T.M. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. (PubMed id 16215985)1 Plans V.... Thomson T.M. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
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External Searches for RNF103 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RNF103 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNF103 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNF103 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RNF103 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNF103 gene: Search GeneIP for patents involving RNF103
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RNF103 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | | RNF103 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF103 |
|  |  |  | | | Search ThermoFisher Antibodies for RNF103 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF103 |
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