Aliases for RNF103 Gene
External Ids for RNF103 Gene
Previous HGNC Symbols for RNF103 Gene
Previous GeneCards Identifiers for RNF103 Gene
The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for RNF103 Gene
RNF103 (Ring Finger Protein 103) is a Protein Coding gene. Diseases associated with RNF103 include Herpes Gestationis. Among its related pathways are Calnexin/calreticulin cycle and Transport to the Golgi and subsequent modification. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for RNF103 Gene
Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.