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Aliases for RNF103 Gene

Aliases for RNF103 Gene

  • Ring Finger Protein 103 2 3
  • Zinc Finger Protein 103 Homolog 3 4
  • RING Finger Protein 103 4 5
  • ZFP-103 3 4
  • ZFP103 3 4
  • HKF-1 3 4
  • KF-1 3 4
  • Zinc Finger Protein Expressed In Cerebellum 3
  • Zinc Finger Protein 103 Homolog (Mouse) 2
  • EC 6.3.2.- 4
  • KF1 3

External Ids for RNF103 Gene

Previous HGNC Symbols for RNF103 Gene

  • ZFP103

Previous GeneCards Identifiers for RNF103 Gene

  • GC02M086788
  • GC02M086805
  • GC02M086742
  • GC02M086584
  • GC02M086830

Summaries for RNF103 Gene

Entrez Gene Summary for RNF103 Gene

  • The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RNF103 Gene

RNF103 (Ring Finger Protein 103) is a Protein Coding gene. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF103 Gene

  • Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF103 Gene

Genomics for RNF103 Gene

Regulatory Elements for RNF103 Gene

Enhancers for RNF103 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNF103 on UCSC Golden Path with GeneCards custom track

Promoters for RNF103 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF103 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF103 Gene

Chromosome:
2
Start:
86,603,393 bp from pter
End:
86,623,877 bp from pter
Size:
20,485 bases
Orientation:
Minus strand

Genomic View for RNF103 Gene

Genes around RNF103 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF103 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF103 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF103 Gene

Proteins for RNF103 Gene

  • Protein details for RNF103 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00237-RN103_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF103
    Protein Accession:
    O00237
    Secondary Accessions:
    • A6NFV6
    • B2RAG4
    • Q53SU6
    • Q8IVB9

    Protein attributes for RNF103 Gene

    Size:
    685 amino acids
    Molecular mass:
    79405 Da
    Quaternary structure:
    • Interacts with DERL1 and VCP.

neXtProt entry for RNF103 Gene

Proteomics data for RNF103 Gene at MOPED

Post-translational modifications for RNF103 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF103 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF103 Gene

Domains & Families for RNF103 Gene

Gene Families for RNF103 Gene

Protein Domains for RNF103 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF103 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00237

UniProtKB/Swiss-Prot:

RN103_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF103: view

Function for RNF103 Gene

Molecular function for RNF103 Gene

UniProtKB/Swiss-Prot Function:
Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

Enzyme Numbers (IUBMB) for RNF103 Gene

Gene Ontology (GO) - Molecular Function for RNF103 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 18675248
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with RNF103: view
genes like me logo Genes that share phenotypes with RNF103: view

Animal Models for RNF103 Gene

MGI Knock Outs for RNF103:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF103 Gene

Localization for RNF103 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF103 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF103 Gene COMPARTMENTS Subcellular localization image for RNF103 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for RNF103 Gene

Pathways & Interactions for RNF103 Gene

SuperPathways for RNF103 Gene

No Data Available

UniProtKB/Swiss-Prot O00237-RN103_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF103 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development TAS 9070305
genes like me logo Genes that share ontologies with RNF103: view

No data available for Pathways by source and SIGNOR curated interactions for RNF103 Gene

Drugs & Compounds for RNF103 Gene

No Compound Related Data Available

Transcripts for RNF103 Gene

Unigene Clusters for RNF103 Gene

Ring finger protein 103:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF103 Gene

No ASD Table

Relevant External Links for RNF103 Gene

GeneLoc Exon Structure for
RNF103
ECgene alternative splicing isoforms for
RNF103

Expression for RNF103 Gene

mRNA expression in normal human tissues for RNF103 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF103 Gene

This gene is overexpressed in Urine (58.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF103 Gene



SOURCE GeneReport for Unigene cluster for RNF103 Gene Hs.469199

mRNA Expression by UniProt/SwissProt for RNF103 Gene

O00237-RN103_HUMAN
Tissue specificity: Highly expressed in the normal cerebellum but not in the cerebral cortex.
genes like me logo Genes that share expression patterns with RNF103: view

Protein tissue co-expression partners for RNF103 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for RNF103 Gene

Orthologs for RNF103 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF103 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF103 35
  • 94.35 (n)
  • 97.3 (a)
RNF103 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF103 35
  • 95.35 (n)
  • 97.75 (a)
RNF103 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf103 35
  • 92.63 (n)
  • 95.64 (a)
Rnf103 16
Rnf103 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF103 35
  • 99.5 (n)
  • 99.4 (a)
rat
(Rattus norvegicus)
Mammalia Rnf103 35
  • 92.38 (n)
  • 95.94 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF103 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF103 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF103 35
  • 80.7 (n)
  • 87.22 (a)
RNF103 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF103 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf103 35
  • 74.07 (n)
  • 82.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17437 35
zebrafish
(Danio rerio)
Actinopterygii rnf103 35
  • 69.41 (n)
  • 76.41 (a)
rnf103 36
  • 74 (a)
OneToOne
Species with no ortholog for RNF103:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF103 Gene

ENSEMBL:
Gene Tree for RNF103 (if available)
TreeFam:
Gene Tree for RNF103 (if available)

Paralogs for RNF103 Gene

No data available for Paralogs for RNF103 Gene

Variants for RNF103 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF103 Gene

Variant ID Type Subtype PubMed ID
nsv436305 CNV Deletion 17901297

Variation tolerance for RNF103 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for RNF103 Gene

Disorders for RNF103 Gene

Relevant External Links for RNF103

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF103

No disorders were found for RNF103 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF103 Gene

Publications for RNF103 Gene

  1. Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. (PMID: 9070305) Yasojima K. … Hashimoto-Gotoh T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23 67
  2. Mulan E3 ubiquitin ligase interacts with multiple E2 conjugating enzymes and participates in mitophagy by recruiting GABARAP. (PMID: 25224329) Ambivero C.T. … Zervos A.S. (Cell. Signal. 2014) 3
  3. Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes. (PMID: 18615712) Scheper J. … Thomson T.M. (Proteins 2009) 3
  4. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3
  5. Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum- associated degradation pathway. (PMID: 18675248) Maruyama Y. … Yamada M. (Biochem. Biophys. Res. Commun. 2008) 3

Products for RNF103 Gene

Sources for RNF103 Gene

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