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Aliases for RNF103 Gene

Aliases for RNF103 Gene

  • Ring Finger Protein 103 2 3
  • ZFP103 3 4 6
  • Zinc Finger Protein 103 Homolog 3 4
  • ZFP-103 3 4
  • HKF-1 3 4
  • KF-1 3 4
  • KF1 3 6
  • Zinc Finger Protein Expressed In Cerebellum 3
  • Zinc Finger Protein 103 Homolog (Mouse) 2
  • E3 Ubiquitin-Protein Ligase RNF103 3
  • RING Finger Protein 103 4
  • EC 6.3.2.- 4

External Ids for RNF103 Gene

Previous HGNC Symbols for RNF103 Gene

  • ZFP103

Previous GeneCards Identifiers for RNF103 Gene

  • GC02M086788
  • GC02M086805
  • GC02M086742
  • GC02M086584
  • GC02M086830

Summaries for RNF103 Gene

Entrez Gene Summary for RNF103 Gene

  • The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RNF103 Gene

RNF103 (Ring Finger Protein 103) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF103 Gene

  • Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF103 Gene

Genomics for RNF103 Gene

Regulatory Elements for RNF103 Gene

Genomic Location for RNF103 Gene

86,603,393 bp from pter
86,623,877 bp from pter
20,485 bases
Minus strand

Genomic View for RNF103 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF103 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF103 Gene

Proteins for RNF103 Gene

  • Protein details for RNF103 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF103
    Protein Accession:
    Secondary Accessions:
    • A6NFV6
    • B2RAG4
    • Q53SU6
    • Q8IVB9

    Protein attributes for RNF103 Gene

    685 amino acids
    Molecular mass:
    79405 Da
    Quaternary structure:
    • Interacts with DERL1 and VCP.

neXtProt entry for RNF103 Gene

Proteomics data for RNF103 Gene at MOPED

Post-translational modifications for RNF103 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF103 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RNF103 Gene

Domains for RNF103 Gene

Gene Families for RNF103 Gene

Protein Domains for RNF103 Gene


Suggested Antigen Peptide Sequences for RNF103 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF103: view

Function for RNF103 Gene

Molecular function for RNF103 Gene

UniProtKB/Swiss-Prot Function:
Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

Enzyme Numbers (IUBMB) for RNF103 Gene

Gene Ontology (GO) - Molecular Function for RNF103 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 10500182
GO:0005515 protein binding IPI 18675248
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF103: view
genes like me logo Genes that share phenotypes with RNF103: view

Animal Models for RNF103 Gene

MGI Knock Outs for RNF103:

Animal Model Products

miRNA for RNF103 Gene

miRTarBase miRNAs that target RNF103

No data available for Transcription Factor Targeting and HOMER Transcription for RNF103 Gene

Localization for RNF103 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF103 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for RNF103 Gene COMPARTMENTS Subcellular localization image for RNF103 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNF103 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 18675248
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF103: view

Pathways for RNF103 Gene

SuperPathways for RNF103 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O00237-RN103_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RNF103 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007417 central nervous system development TAS 9070305
GO:0016567 protein ubiquitination IEA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IDA 18675248
genes like me logo Genes that share ontologies with RNF103: view

No data available for Pathways by source for RNF103 Gene

Transcripts for RNF103 Gene

Unigene Clusters for RNF103 Gene

Ring finger protein 103:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF103

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF103 Gene

No ASD Table

Relevant External Links for RNF103 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF103 Gene

mRNA expression in normal human tissues for RNF103 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RNF103 Gene

This gene is overexpressed in Urine (58.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF103 Gene

SOURCE GeneReport for Unigene cluster for RNF103 Gene Hs.469199

mRNA Expression by UniProt/SwissProt for RNF103 Gene

Tissue specificity: Highly expressed in the normal cerebellum but not in the cerebral cortex.
genes like me logo Genes that share expressions with RNF103: view

Expression partners for RNF103 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RNF103 Gene

Orthologs for RNF103 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF103 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNF103 35
  • 94.35 (n)
  • 97.3 (a)
RNF103 36
  • 97 (a)
(Canis familiaris)
Mammalia RNF103 35
  • 95.35 (n)
  • 97.75 (a)
RNF103 36
  • 98 (a)
(Mus musculus)
Mammalia Rnf103 35
  • 92.63 (n)
  • 95.64 (a)
Rnf103 16
Rnf103 36
  • 96 (a)
(Pan troglodytes)
Mammalia RNF103 35
  • 99.5 (n)
  • 99.4 (a)
(Rattus norvegicus)
Mammalia Rnf103 35
  • 92.38 (n)
  • 95.94 (a)
(Monodelphis domestica)
Mammalia RNF103 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia RNF103 36
  • 86 (a)
(Gallus gallus)
Aves RNF103 35
  • 80.7 (n)
  • 87.22 (a)
RNF103 36
  • 87 (a)
(Anolis carolinensis)
Reptilia RNF103 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf103 35
  • 74.07 (n)
  • 82.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17437 35
(Danio rerio)
Actinopterygii rnf103 35
  • 69.41 (n)
  • 76.41 (a)
rnf103 36
  • 74 (a)
Species with no ortholog for RNF103:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF103 Gene

Gene Tree for RNF103 (if available)
Gene Tree for RNF103 (if available)

Paralogs for RNF103 Gene

No data available for Paralogs for RNF103 Gene

Variants for RNF103 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF103 Gene

Variant ID Type Subtype PubMed ID
nsv436305 CNV Deletion 17901297

Relevant External Links for RNF103 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RNF103 Gene

Disorders for RNF103 Gene

No disorders were found for RNF103 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RNF103 Gene

Publications for RNF103 Gene

  1. Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. (PMID: 9070305) Yasojima K. … Hashimoto-Gotoh T. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum- associated degradation pathway. (PMID: 18675248) Maruyama Y. … Yamada M. (Biochem. Biophys. Res. Commun. 2008) 3 4
  3. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PMID: 10500182) Lorick K.L. … Weissman A.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RNF103 Gene

Sources for RNF103 Gene

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