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Aliases for RNF10 Gene

Aliases for RNF10 Gene

  • Ring Finger Protein 10 2 3
  • RIE2 3 4
  • KIAA0262 4

External Ids for RNF10 Gene

Previous GeneCards Identifiers for RNF10 Gene

  • GC12P119852
  • GC12P120755
  • GC12P119384
  • GC12P119434
  • GC12P120972
  • GC12P117981

Summaries for RNF10 Gene

Entrez Gene Summary for RNF10 Gene

  • The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF10 Gene

RNF10 (Ring Finger Protein 10) is a Protein Coding gene. GO annotations related to this gene include transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for RNF10 Gene

  • Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Wiki entry for RNF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF10 Gene

Genomics for RNF10 Gene

Regulatory Elements for RNF10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNF10 Gene

120,533,480 bp from pter
120,577,594 bp from pter
44,115 bases
Plus strand

Genomic View for RNF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF10 Gene

Proteins for RNF10 Gene

  • Protein details for RNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 10
    Protein Accession:
    Secondary Accessions:
    • Q92550
    • Q9NPP8
    • Q9ULW4

    Protein attributes for RNF10 Gene

    811 amino acids
    Molecular mass:
    89927 Da
    Quaternary structure:
    • Interacts with MEOX2.

    Alternative splice isoforms for RNF10 Gene


neXtProt entry for RNF10 Gene

Proteomics data for RNF10 Gene at MOPED

Post-translational modifications for RNF10 Gene

  • Ubiquitination at Lys105, Lys136, Lys137, Lys167, Lys236, and Lys337
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF10 Gene

Domains for RNF10 Gene

Gene Families for RNF10 Gene

  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF10 Gene

Suggested Antigen Peptide Sequences for RNF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8N5U6
  • Belongs to the RNF10 family.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF10: view

Function for RNF10 Gene

Molecular function for RNF10 Gene

UniProtKB/Swiss-Prot Function: Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Ontology (GO) - Molecular Function for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 16335786
GO:0008270 zinc ion binding IEA --
GO:0044212 transcription regulatory region DNA binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF10: view
genes like me logo Genes that share phenotypes with RNF10: view

Animal Model Products

CRISPR Products

miRNA for RNF10 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF10 Gene

Localization for RNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for RNF10 Gene COMPARTMENTS Subcellular localization image for RNF10 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 16335786
genes like me logo Genes that share ontologies with RNF10: view

Pathways for RNF10 Gene

SuperPathways for RNF10 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for RNF10 Gene

Gene Ontology (GO) - Biological Process for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010626 negative regulation of Schwann cell proliferation ISS --
GO:0031643 positive regulation of myelination ISS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 16335786
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with RNF10: view

No data available for Pathways by source for RNF10 Gene

Transcripts for RNF10 Gene

Unigene Clusters for RNF10 Gene

Ring finger protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNF10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: -
SP2: -
SP7: - - -
SP8: - -
SP9: - - - -
SP13: - -
SP14: - -
SP15: - -
SP18: - - - - - -

ExUns: 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP4: - -
SP5: - -
SP6: -
SP10: -
SP11: -
SP13: - - -

Relevant External Links for RNF10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF10 Gene

mRNA expression in normal human tissues for RNF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF10 Gene

This gene is overexpressed in Whole Blood (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF10 Gene

SOURCE GeneReport for Unigene cluster for RNF10 Gene Hs.442798

genes like me logo Genes that share expressions with RNF10: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF10 Gene

Orthologs for RNF10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF10 35
  • 99.71 (n)
  • 99.63 (a)
RNF10 36
  • 100 (a)
(Bos Taurus)
Mammalia RNF10 35
  • 93.37 (n)
  • 93.83 (a)
RNF10 36
  • 94 (a)
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
-- 36
  • 77 (a)
RNF10 35
  • 93.8 (n)
  • 94.54 (a)
(Mus musculus)
Mammalia Rnf10 35
  • 91.42 (n)
  • 92.79 (a)
Rnf10 16
Rnf10 36
  • 93 (a)
(Monodelphis domestica)
Mammalia RNF10 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Rnf10 35
  • 91.06 (n)
  • 93.27 (a)
(Gallus gallus)
Aves RNF10 35
  • 75.11 (n)
  • 75.83 (a)
RNF10 36
  • 71 (a)
(Anolis carolinensis)
Reptilia RNF10 36
  • 71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22040 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75603 35
rnf10 35
  • 66.25 (n)
  • 65.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9616 35
(Danio rerio)
Actinopterygii rnf10 35
  • 63.37 (n)
  • 61.95 (a)
rnf10 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007954 35
  • 49.45 (n)
  • 40.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12099 35
  • 47.79 (n)
  • 39.38 (a)
CG12099 36
  • 35 (a)
CG12099 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAG2 36
  • 24 (a)
MAG2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4621 36
  • 36 (a)
Species with no ortholog for RNF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF10 Gene

Gene Tree for RNF10 (if available)
Gene Tree for RNF10 (if available)

Paralogs for RNF10 Gene Pseudogenes for RNF10 Gene

genes like me logo Genes that share paralogs with RNF10: view

No data available for Paralogs for RNF10 Gene

Variants for RNF10 Gene

Sequence variations from dbSNP and Humsavar for RNF10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10056 -- 120,576,600(+) AAGGN(G/T)GAAAG reference, frameshift-variant, nc-transcript-variant
rs10505 -- 120,576,998(-) CTGCT(A/C)TAATG utr-variant-3-prime, nc-transcript-variant
rs488313 -- 120,573,203(-) tatta(A/C/G/T)tgtgg intron-variant
rs489854 -- 120,567,862(+) ATGGg(G/T)gtgtg intron-variant
rs492574 -- 120,568,155(-) CCATC(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF10 Gene

Variant ID Type Subtype PubMed ID
nsv906 CNV Loss 18451855
esv2746473 CNV Deletion 23290073

Relevant External Links for RNF10 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF10 Gene

Disorders for RNF10 Gene

No disorders were found for RNF10 Gene.

No data available for UniProtKB/Swiss-Prot for RNF10 Gene

Publications for RNF10 Gene

  1. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. (PMID: 10697961) Seki N. … Saito T. (J. Hum. Genet. 2000) 3 4 23
  2. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J. … Wigle J.T. (Mol. Cell. Biochem. 2005) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RNF10 Gene

Sources for RNF10 Gene

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