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Aliases for RNF10 Gene

Aliases for RNF10 Gene

  • Ring Finger Protein 10 2 3 5
  • RIE2 3 4
  • KIAA0262 4

External Ids for RNF10 Gene

Previous GeneCards Identifiers for RNF10 Gene

  • GC12P119852
  • GC12P120755
  • GC12P119384
  • GC12P119434
  • GC12P120972
  • GC12P117981

Summaries for RNF10 Gene

Entrez Gene Summary for RNF10 Gene

  • The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF10 Gene

RNF10 (Ring Finger Protein 10) is a Protein Coding gene. Diseases associated with RNF10 include Charcot-Marie-Tooth Disease, Axonal, Type 2L. GO annotations related to this gene include ubiquitin-protein transferase activity and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for RNF10 Gene

  • Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Wiki entry for RNF10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF10 Gene

Genomics for RNF10 Gene

Regulatory Elements for RNF10 Gene

Enhancers for RNF10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G120494 1.1 ENCODE 12.6 -36.9 -36880 3.5 HDGF ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 COQ5 GATC RPL29P24 RNF10 DYNLL1 SRSF9 RPL31P52 TRIAP1 ENSG00000111780 COX6A1
GH12G120498 0.6 ENCODE 12.4 -34.3 -34302 0.5 PAF1 GATAD2A HLF FEZF1 KMT2B TEAD3 NFIL3 POLR2A ZNF18 GATC RPL29P24 RNF10 COQ5 RPL31P52 TRIAP1 ENSG00000111780 COX6A1 GC12P120497 ENSG00000278344
GH12G120223 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.5 -301.9 -301896 16.0 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC PXN SIRT4 RPLP0 RNU4-1 RNU4-2 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
GH12G120554 0.5 ENCODE 11.8 +21.3 21338 1.1 BCOR HDAC2 ADNP ZBTB17 COQ5 GATC RNF10 RPL29P24 RPL31P52 TRIAP1 ENSG00000111780 GC12P120535 POP5
GH12G120239 2.1 FANTOM5 Ensembl ENCODE dbSUPER 2.5 -284.0 -283950 19.3 CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GCN1 SIRT4 RNU4-1 RNU4-2 RNU6-1088P PLA2G1B PXN BICDL1 RNF10 RAB35
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF10 on UCSC Golden Path with GeneCards custom track

Promoters for RNF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058325 1520 2001 PKNOX1 FOXA2 CREB3L1 ARNT SIN3A ARID4B ZNF2 YY1 ZNF207 ZNF143

Genomic Location for RNF10 Gene

Chromosome:
12
Start:
120,533,480 bp from pter
End:
120,577,594 bp from pter
Size:
44,115 bases
Orientation:
Plus strand

Genomic View for RNF10 Gene

Genes around RNF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF10 Gene

Proteins for RNF10 Gene

  • Protein details for RNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5U6-RNF10_HUMAN
    Recommended name:
    RING finger protein 10
    Protein Accession:
    Q8N5U6
    Secondary Accessions:
    • Q92550
    • Q9NPP8
    • Q9ULW4

    Protein attributes for RNF10 Gene

    Size:
    811 amino acids
    Molecular mass:
    89927 Da
    Quaternary structure:
    • Interacts with MEOX2.

    Alternative splice isoforms for RNF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF10 Gene

Post-translational modifications for RNF10 Gene

  • Ubiquitination at Lys105, Lys136, Lys137, Lys167, Lys236, and isoforms=2337
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF10 Gene

Domains & Families for RNF10 Gene

Gene Families for RNF10 Gene

Protein Domains for RNF10 Gene

Suggested Antigen Peptide Sequences for RNF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5U6

UniProtKB/Swiss-Prot:

RNF10_HUMAN :
  • Belongs to the RNF10 family.
Family:
  • Belongs to the RNF10 family.
genes like me logo Genes that share domains with RNF10: view

Function for RNF10 Gene

Molecular function for RNF10 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Ontology (GO) - Molecular Function for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 16335786
GO:0008270 zinc ion binding IEA --
GO:0044212 transcription regulatory region DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF10: view
genes like me logo Genes that share phenotypes with RNF10: view

Animal Models for RNF10 Gene

MGI Knock Outs for RNF10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF10 Gene

Localization for RNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF10 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA,IEA 16335786
genes like me logo Genes that share ontologies with RNF10: view

Pathways & Interactions for RNF10 Gene

SuperPathways for RNF10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010626 negative regulation of Schwann cell proliferation ISS --
GO:0031643 positive regulation of myelination ISS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 16335786
genes like me logo Genes that share ontologies with RNF10: view

No data available for Pathways by source and SIGNOR curated interactions for RNF10 Gene

Drugs & Compounds for RNF10 Gene

No Compound Related Data Available

Transcripts for RNF10 Gene

Unigene Clusters for RNF10 Gene

Ring finger protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - -
SP9: - - - -
SP10:
SP11:
SP12:
SP13: - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - -

ExUns: 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4: - -
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RNF10 Gene

GeneLoc Exon Structure for
RNF10
ECgene alternative splicing isoforms for
RNF10

Expression for RNF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF10 Gene

This gene is overexpressed in Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for RNF10 Gene

This gene is overexpressed in Adipocyte (48.4) and Placenta (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF10 Gene



Protein tissue co-expression partners for RNF10 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF10 Gene:

RNF10

SOURCE GeneReport for Unigene cluster for RNF10 Gene:

Hs.442798

Evidence on tissue expression from TISSUES for RNF10 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Eye(4.5)
  • Bone marrow(4.4)
  • Lung(3.9)
  • Kidney(3.7)
  • Intestine(3.4)
  • Skin(3.2)
  • Blood(2.9)
  • Spleen(2.7)
  • Heart(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with RNF10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF10 Gene

Orthologs for RNF10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF10 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia RNF10 34
  • 93.8 (n)
-- 35
  • 83 (a)
OneToMany
-- 35
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RNF10 34 35
  • 93.37 (n)
mouse
(Mus musculus)
Mammalia Rnf10 34 16 35
  • 91.42 (n)
rat
(Rattus norvegicus)
Mammalia Rnf10 34
  • 91.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RNF10 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF10 34 35
  • 75.11 (n)
lizard
(Anolis carolinensis)
Reptilia RNF10 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf10 34
  • 66.25 (n)
MGC75603 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22040 34
zebrafish
(Danio rerio)
Actinopterygii rnf10 34 35
  • 63.37 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9616 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007954 34
  • 49.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12099 36 34 35
  • 47.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAG2 35 37
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4621 35
  • 36 (a)
OneToOne
Species where no ortholog for RNF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF10 Gene

ENSEMBL:
Gene Tree for RNF10 (if available)
TreeFam:
Gene Tree for RNF10 (if available)

Paralogs for RNF10 Gene

Pseudogenes.org Pseudogenes for RNF10 Gene

genes like me logo Genes that share paralogs with RNF10: view

No data available for Paralogs for RNF10 Gene

Variants for RNF10 Gene

Sequence variations from dbSNP and Humsavar for RNF10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000027673 -- 120,535,007(+) ACTGC(C/T)CCTGC intron-variant
rs1000171510 -- 120,563,320(+) CCTTT(C/G)TGTTG intron-variant
rs1000206811 -- 120,554,160(+) TCGGC(C/T)TCCCA intron-variant
rs1000426729 -- 120,548,559(+) AAACA(A/G)CAAAT intron-variant
rs1000494847 -- 120,571,088(+) GGGAT(A/G)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF10 Gene

Variant ID Type Subtype PubMed ID
esv2746473 CNV deletion 23290073
esv3630927 CNV loss 21293372
nsv906 CNV deletion 18451855

Variation tolerance for RNF10 Gene

Residual Variation Intolerance Score: 3.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF10 Gene

Disorders for RNF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2l
  • charcot-marie-tooth disease axonal type 2l
- elite association - COSMIC cancer census association via MalaCards
Search RNF10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNF10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF10
genes like me logo Genes that share disorders with RNF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF10 Gene

Publications for RNF10 Gene

  1. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J. … Wigle J.T. (Mol. Cell. Biochem. 2005) 3 4 22 64
  2. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. (PMID: 10697961) Seki N. … Saito T. (J. Hum. Genet. 2000) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64

Products for RNF10 Gene

Sources for RNF10 Gene

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