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Aliases for RNF10 Gene

Aliases for RNF10 Gene

  • Ring Finger Protein 10 2 3 5
  • RIE2 3 4
  • KIAA0262 4

External Ids for RNF10 Gene

Previous GeneCards Identifiers for RNF10 Gene

  • GC12P119852
  • GC12P120755
  • GC12P119384
  • GC12P119434
  • GC12P120972
  • GC12P117981

Summaries for RNF10 Gene

Entrez Gene Summary for RNF10 Gene

  • The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF10 Gene

RNF10 (Ring Finger Protein 10) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for RNF10 Gene

  • Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Wiki entry for RNF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF10 Gene

Genomics for RNF10 Gene

Regulatory Elements for RNF10 Gene

Promoters for RNF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNF10 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNF10 Gene

Chromosome:
12
Start:
120,533,480 bp from pter
End:
120,577,594 bp from pter
Size:
44,115 bases
Orientation:
Plus strand

Genomic View for RNF10 Gene

Genes around RNF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF10 Gene

Proteins for RNF10 Gene

  • Protein details for RNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5U6-RNF10_HUMAN
    Recommended name:
    RING finger protein 10
    Protein Accession:
    Q8N5U6
    Secondary Accessions:
    • Q92550
    • Q9NPP8
    • Q9ULW4

    Protein attributes for RNF10 Gene

    Size:
    811 amino acids
    Molecular mass:
    89927 Da
    Quaternary structure:
    • Interacts with MEOX2.

    Alternative splice isoforms for RNF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF10 Gene

Proteomics data for RNF10 Gene at MOPED

Post-translational modifications for RNF10 Gene

  • Ubiquitination at Lys 105, Lys 136, Lys 137, Lys 167, Lys 236, and Lys 337
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RNF10 Gene

Domains & Families for RNF10 Gene

Gene Families for RNF10 Gene

Protein Domains for RNF10 Gene

Suggested Antigen Peptide Sequences for RNF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5U6

UniProtKB/Swiss-Prot:

RNF10_HUMAN :
  • Belongs to the RNF10 family.
  • Contains 1 RING-type zinc finger.
Family:
  • Belongs to the RNF10 family.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with RNF10: view

Function for RNF10 Gene

Molecular function for RNF10 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Ontology (GO) - Molecular Function for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IEA,IPI 16335786
GO:0044212 transcription regulatory region DNA binding ISS --
genes like me logo Genes that share ontologies with RNF10: view
genes like me logo Genes that share phenotypes with RNF10: view

Animal Models for RNF10 Gene

MGI Knock Outs for RNF10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF10 Gene

Localization for RNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF10 Gene COMPARTMENTS Subcellular localization image for RNF10 gene
Compartment Confidence
nucleus 5
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for RNF10 Gene

Pathways & Interactions for RNF10 Gene

SuperPathways for RNF10 Gene

No Data Available

Interacting Proteins for RNF10 Gene

Gene Ontology (GO) - Biological Process for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010626 negative regulation of Schwann cell proliferation ISS --
GO:0031643 positive regulation of myelination ISS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 16335786
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF10: view

No data available for Pathways by source and SIGNOR curated interactions for RNF10 Gene

Drugs & Compounds for RNF10 Gene

No Compound Related Data Available

Transcripts for RNF10 Gene

Unigene Clusters for RNF10 Gene

Ring finger protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - -
SP9: - - - -
SP10:
SP11:
SP12:
SP13: - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - -

ExUns: 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4: - -
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RNF10 Gene

GeneLoc Exon Structure for
RNF10
ECgene alternative splicing isoforms for
RNF10

Expression for RNF10 Gene

mRNA expression in normal human tissues for RNF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF10 Gene

This gene is overexpressed in Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for RNF10 Gene

This gene is overexpressed in Adipocyte (48.4) and Placenta (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF10 Gene



SOURCE GeneReport for Unigene cluster for RNF10 Gene Hs.442798

genes like me logo Genes that share expression patterns with RNF10: view

Protein tissue co-expression partners for RNF10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RNF10 Gene

Orthologs for RNF10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNF10 35
  • 93.37 (n)
  • 93.83 (a)
RNF10 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF10 35
  • 93.8 (n)
  • 94.54 (a)
-- 36
  • 83 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rnf10 35
  • 91.42 (n)
  • 92.79 (a)
Rnf10 16
Rnf10 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNF10 35
  • 99.71 (n)
  • 99.63 (a)
RNF10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf10 35
  • 91.06 (n)
  • 93.27 (a)
oppossum
(Monodelphis domestica)
Mammalia RNF10 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves RNF10 35
  • 75.11 (n)
  • 75.83 (a)
RNF10 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF10 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75603 35
rnf10 35
  • 66.25 (n)
  • 65.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22040 35
zebrafish
(Danio rerio)
Actinopterygii rnf10 35
  • 63.37 (n)
  • 61.95 (a)
rnf10 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9616 35
fruit fly
(Drosophila melanogaster)
Insecta CG12099 37
  • 34 (a)
CG12099 35
  • 47.79 (n)
  • 39.38 (a)
CG12099 36
  • 35 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007954 35
  • 49.45 (n)
  • 40.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAG2 36
  • 24 (a)
OneToOne
MAG2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4621 36
  • 36 (a)
OneToOne
Species with no ortholog for RNF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF10 Gene

ENSEMBL:
Gene Tree for RNF10 (if available)
TreeFam:
Gene Tree for RNF10 (if available)

Paralogs for RNF10 Gene

Pseudogenes.org Pseudogenes for RNF10 Gene

genes like me logo Genes that share paralogs with RNF10: view

No data available for Paralogs for RNF10 Gene

Variants for RNF10 Gene

Sequence variations from dbSNP and Humsavar for RNF10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17852961 - 120,560,754(+) AAGTT(G/T)CTGCT nc-transcript-variant, reference, missense
rs16950277 - 120,563,391(+) ACGGA(A/T)GTTTG nc-transcript-variant, reference, missense
rs10056 -- 120,576,601(+) AAGGA(G/T)GAAAG nc-transcript-variant, reference, stop-gained
rs10505 -- 120,576,998(-) CTGCT(A/C)TAATG nc-transcript-variant, utr-variant-3-prime
rs488313 -- 120,573,203(-) tatta(A/C/G/T)tgtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF10 Gene

Variant ID Type Subtype PubMed ID
nsv906 CNV Loss 18451855
esv2746473 CNV Deletion 23290073

Variation tolerance for RNF10 Gene

Residual Variation Intolerance Score: 3.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF10 Gene

HapMap Linkage Disequilibrium report
RNF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF10 Gene

Disorders for RNF10 Gene

Relevant External Links for RNF10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF10

No disorders were found for RNF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF10 Gene

Publications for RNF10 Gene

  1. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. (PMID: 10697961) Seki N. … Saito T. (J. Hum. Genet. 2000) 3 4 23 67
  2. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J. … Wigle J.T. (Mol. Cell. Biochem. 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Protein microarray characterization of the S-nitrosoproteome. (PMID: 24105792) Lee Y.I. … Dawson T.M. (Mol. Cell Proteomics 2014) 3
  5. Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes. (PMID: 24151200) Huang K. … Baier L.J. (Obesity (Silver Spring) 2014) 3

Products for RNF10 Gene

Sources for RNF10 Gene

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