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RNF10 Gene

protein-coding   GIFtS: 55
GCID: GC12P120972

Ring Finger Protein 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein 101 2
RIE22 3
KIAA02623

External Ids:    HGNC: 100551   Entrez Gene: 99212   Ensembl: ENSG000000228407   UniProtKB: Q8N5U63   

Export aliases for RNF10 gene to outside databases

Previous GC identifers: GC12P119852 GC12P120569 GC12P120755 GC12P119384 GC12P119434 GC12P117981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNF10 Gene:
The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein
interactions. The specific function of this protein has not yet been determined. EST data suggests the existence
of multiple alternatively spliced transcript variants, however, their full length nature is not known. (provided
by RefSeq, Jul 2008)

GeneCards Summary for RNF10 Gene:
RNF10 (ring finger protein 10) is a protein-coding gene. Diseases associated with RNF10 include herpes simplex, and kidney disease. GO annotations related to this gene include transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot: RNF10_HUMAN, Q8N5U6
Function: Transcriptional factor involved in the regulation of MAG expression. Participates in the peripheral
nerve development and Schawnn cell differentiation (By similarity)

Gene Wiki entry for RNF10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNF10 gene promoter:
         c-Fos   AP-1   NF-YA   NF-YB   CBF-A   CBF-B   c-Jun   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNF10 promoter sequence
   Search Chromatin IP Primers for RNF10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q23-q24

RNF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNF10 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P120972:  view genomic region     (about GC identifiers)

Start:
120,971,283 bp from pter      End:
121,015,397 bp from pter
Size:
44,115 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RNF10_HUMAN, Q8N5U6 (See protein sequence)
Recommended Name: RING finger protein 10  
Size: 811 amino acids; 89927 Da
Subunit: Interacts with MEOX2
Secondary accessions: Q92550 Q9NPP8 Q9ULW4
Alternative splicing: 2 isoforms:  Q8N5U6-1   Q8N5U6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNF10: NX_Q8N5U6

Explore proteomics data for RNF10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys105, Lys136, Lys137, Lys167, Lys236, Lys337
  • Modification sites at PhosphoSitePlus

  • See RNF10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055683.3  
    ENSEMBL proteins: 
     ENSP00000438638   ENSP00000322242   ENSP00000444770   ENSP00000443000   ENSP00000415682  
     ENSP00000443790   ENSP00000443235   ENSP00000439510   ENSP00000437392   ENSP00000439221  
     ENSP00000439859   ENSP00000445160   ENSP00000441487  

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    Novus Biologicals RNF10 Lysates
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    Cloud-Clone Corp. Proteins for RNF10

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    3 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8N5U6

    ProtoNet protein and cluster: Q8N5U6

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF10_HUMAN, Q8N5U6
    Similarity: Belongs to the RNF10 family
    Similarity: Contains 1 RING-type zinc finger


    RNF10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF10_HUMAN, Q8N5U6
    Function: Transcriptional factor involved in the regulation of MAG expression. Participates in the peripheral
    nerve development and Schawnn cell differentiation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16335786
    GO:0008270zinc ion binding IEA--
    GO:0044212transcription regulatory region DNA binding ISS--
    GO:0046872metal ion binding ----
         
    RNF10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RNF10:
     Decreased viability of wild-ty 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rnf10):
     adipose tissue  behavior/neurological  cellular  growth/size/body  hematopoietic system 

    RNF10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNF10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNF10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNF10

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNF10:
    hsa-mir-222-3p (MIRT046718), hsa-mir-484 (MIRT041789), hsa-mir-130b-5p (MIRT038323), hsa-mir-877-3p (MIRT036845), hsa-mir-320a (MIRT044532)

    Block miRNA regulation of human, mouse, rat RNF10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF10 (see all 23):
    hsa-miR-875-3p hsa-miR-137 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-218-1* hsa-miR-25 hsa-miR-3129-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidRNF10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RNF10
    Predesigned siRNA for gene silencing in human, mouse, rat RNF10

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    GenScript: all cDNA clones in your preferred vector (see all 3): RNF10 (NM_001198951)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF10

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF10_HUMAN, Q8N5U6: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA16335786

    RNF10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNF10: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNF10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNF10 (Q8N5U62, 3 ENSP000003222424) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC90BQ9GZT62, 3MINT-65763 I2D: score=5 
    SETDB1Q150472, 3MINT-65760 I2D: score=5 
    UTP14AQ9BVJ62, 3MINT-65762 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-65764 I2D: score=4 
    TLE1Q047242, 3MINT-65759 I2D: score=4 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0010626negative regulation of Schwann cell proliferation ISS--
    GO:0031643positive regulation of myelination ISS--
    GO:0045893positive regulation of transcription, DNA-templated IDA16335786
    GO:0045944positive regulation of transcription from RNA polymerase II promoter ISS--

    RNF10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNF10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNF10 gene: 
    NM_014868.4  

    Unigene Cluster for RNF10:

    Ring finger protein 10
    Hs.442798  [show with all ESTs]
    Unigene Representative Sequence: NM_014868
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000539486 ENST00000325954(uc001typ.4 uc010szk.2 uc001tyq.4)
    ENST00000542438 ENST00000538796 ENST00000413266 ENST00000551139 ENST00000536869
    ENST00000537997 ENST00000543578 ENST00000535417 ENST00000542207 ENST00000543675
    ENST00000537740 ENST00000537376 ENST00000546262 ENST00000544124 ENST00000540046
    ENST00000545419
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNF10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNF10 (see all 23):
    hsa-miR-875-3p hsa-miR-137 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-218-1* hsa-miR-25 hsa-miR-3129-5p hsa-miR-578
    SwitchGear 3'UTR luciferase reporter plasmidRNF10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNF10
    Predesigned siRNA for gene silencing in human, mouse, rat RNF10
    Clone
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    OriGene clones in human, mouse for RNF10 (see all 6)
    OriGene ORF clones in mouse, rat for RNF10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): RNF10 (NM_001198951)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNF10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNF10
    Primer
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    OriGene qPCR primer pairs and template standards for RNF10
    OriGene qSTAR qPCR primer pairs in human, mouse for RNF10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF10
      QuantiTect SYBR Green Assays in human, mouse, rat RNF10
      QuantiFast Probe-based Assays in human, mouse, rat RNF10

    Additional mRNA sequence: 

    AB027196.1 AK094011.1 AK097807.1 AK126274.1 AK301608.1 AK315558.1 AL389976.1 BC016622.1 
    BC031596.1 BC101709.1 BC101715.1 BT006974.1 D87451.2 

    Selected DOTS entries (see all 47):

    DT.100687173  DT.97855295  DT.92457014  DT.454204  DT.100830264  DT.100031590  DT.100696576  DT.121144850 
    DT.100830260  DT.121144756  DT.91898152  DT.91925484  DT.433472  DT.121144766  DT.121144965  DT.423173 
    DT.100830262  DT.121144964  DT.92457011  DT.100830256  DT.121144853  DT.121144995  DT.100830261  DT.121144746 

    Selected AceView cDNA sequences (see all 710):

    BE268029 CA390546 BQ009608 AW953025 F36155 AW271429 AI923788 BF569387 
    BE045985 BM834556 AI418238 BM790148 BM835640 BQ057677 NM_014868 BQ184555 
    BP366374 AA460029 BE790534 D87451 AI754186 BM471027 BM707800 AU104422 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNF10 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
    SP1:                                                                                -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:                                                                                                                  
    SP4:                          -                             -                                                         
    SP5:                          -                             -                                                         


    ECgene alternative splicing isoforms for RNF10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNF10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTGTTTG
    RNF10 Expression
    About this image


    RNF10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    RNF10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNF10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442798
        Pathway & Disease-focused RT2 Profiler PCR Array including RNF10: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNF10
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNF10
    QuantiTect SYBR Green Assays in human, mouse, rat RNF10
    QuantiFast Probe-based Assays in human, mouse, rat RNF10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNF10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNF10 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnf101 , 5 ring finger protein 101, 5 91.42(n)1
    92.79(a)1
      5 (56.01 cM)5
    508491  NM_016698.21  NP_057907.21 
     1152414125 
    chicken
    (Gallus gallus)
    Aves RNF101 ring finger protein 10 75.11(n)
    75.83(a)
      416974  XM_415267.4  XP_415267.2 
    lizard
    (Anolis carolinensis)
    Reptilia RNF106
    ring finger protein 10
    71(a)
    1 ↔ 1
    GL343338.1(97540-108056)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.220402 Xenopus laevis transcribed sequence with weak similarity more 74.54(n)    BQ725579.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnf101 ring finger protein 10 63.37(n)
    61.95(a)
      560444  NM_001123255.1  NP_001116727.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120991 , 3 CG120991 34(a)3
    47.79(n)1
    39.38(a)1
      62A53
    381811  NM_139366.31  NP_647623.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MAG2(YLR427W)4 Cytoplasmic protein of unknown function; induced in more   --   12(988428-990440) 851147  NP_013531.1 


    ENSEMBL Gene Tree for RNF10 (if available)
    TreeFam Gene Tree for RNF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNF10 gene

    RNF10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNF10
    PGOHUM00000237524


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNF10 (see all 1091)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58013881,2
    C--120772226(+) ttttt-/T/TTT 
            
    gagac
    1 -- int1 trp31NA 2
    rs348896491,2
    C--120787832(+) TCTCA-/AAAAAA 1 -- int10--------
    rs351942421,2
    C--120798049(+) ATCTC-/A/AA  
            
    AAAAA
    1 -- int11NA 2
    rs1443166131,2
    --120970215(+) GTGCCC/TGGCCC 1 -- us2k10--------
    rs747332401,2
    C,F--120970296(+) CATCAC/TTTGTT 1 -- us2k12Minor allele frequency- T:0.19CSA WA 120
    rs123674711,2
    C,F--120970369(+) tatttA/Ctttag 1 -- us2k13Minor allele frequency- C:0.03NA 124
    rs118308331,2
    C,H--120970429(+) aagtgG/Atcatc 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1823596411,2
    --120970495(+) TTATTA/GAGAAG 1 -- us2k10--------
    rs1892483361,2
    --120970562(+) TGCACC/TGAGCT 1 -- us2k10--------
    rs762607521,2
    C,F--120970578(+) ACAGTA/TGACCA 1 -- us2k12Minor allele frequency- T:0.19CSA WA 120

    HapMap Linkage Disequilibrium report for RNF10 (120971283 - 121015397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNF10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746473CNV Deletion23290073
    nsv906CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNF10
    DNA2.0 Custom Variant and Variant Library Synthesis for RNF10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for RNF10:    
    About MalaCards
    herpes simplex    kidney disease    type 1 diabetes    malaria


    RNF10 for disorders           About GeneDecksing


    Export disorders for RNF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNF10 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with RNF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. (PubMed id 10697961)1, 2, 9 Seki N.... Saito T. (J. Hum. Genet. 2000)
    2. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PubMed id 16335786)1, 2, 9 Lin J.... Wigle J.T. (Mol. Cell. Biochem. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    6. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. (PubMed id 24211586)1 Uhler J.P....Gustafsson C.M. (Biochem. Biophys. Res. Commun. 2014)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    9. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9921 HGNC: 10055 AceView: RNF10 Ensembl:ENSG00000022840 euGenes: HUgn9921
    ECgene: RNF10 H-InvDB: RNF10

    (According to HUGE)
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    HUGE: KIAA0262

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNF10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNF10 gene:
    Search GeneIP for patents involving RNF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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