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Aliases for RNF10 Gene

Aliases for RNF10 Gene

  • Ring Finger Protein 10 2 3
  • RIE2 3 4
  • KIAA0262 4

External Ids for RNF10 Gene

Summaries for RNF10 Gene

Entrez Gene Summary for RNF10 Gene

  • The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF10 Gene

RNF10 (Ring Finger Protein 10) is a Protein Coding gene. GO annotations related to this gene include transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for RNF10 Gene

  • Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Wiki entry for RNF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF10 Gene

Genomics for RNF10 Gene

Genomic Location for RNF10 Gene

Start:
120,533,480 bp from pter
End:
120,577,594 bp from pter
Size:
44,115 bases
Orientation:
Plus strand

Genomic View for RNF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF10 Gene

Regulatory Elements for RNF10 Gene

Proteins for RNF10 Gene

  • Protein details for RNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5U6-RNF10_HUMAN
    Recommended name:
    RING finger protein 10
    Protein Accession:
    Q8N5U6
    Secondary Accessions:
    • Q92550
    • Q9NPP8
    • Q9ULW4

    Protein attributes for RNF10 Gene

    Size:
    811 amino acids
    Molecular mass:
    89927 Da
    Quaternary structure:
    • Interacts with MEOX2.

    Alternative splice isoforms for RNF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF10 Gene

Proteomics data for RNF10 Gene at MOPED

Post-translational modifications for RNF10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys105, Lys136, Lys137, Lys167, Lys236, and Lys337

No data available for DME Specific Peptides for RNF10 Gene

Domains for RNF10 Gene

Gene Families for RNF10 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for RNF10 Gene

UniProtKB/Swiss-Prot:

RNF10_HUMAN
Family:
  • Belongs to the RNF10 family.:
    • Q8N5U6
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8N5U6
genes like me logo Genes that share domains with RNF10: view

Function for RNF10 Gene

Molecular function for RNF10 Gene

UniProtKB/Swiss-Prot Function: Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Ontology (GO) - Molecular Function for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 16335786
GO:0008270 zinc ion binding IEA --
GO:0044212 transcription regulatory region DNA binding ISS --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RNF10: view
genes like me logo Genes that share phenotypes with RNF10: view

miRNA for RNF10 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNF10 Gene

Localization for RNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNF10 Gene COMPARTMENTS Subcellular localization image for RNF10 gene
Compartment Confidence
nucleus 4
cytosol 1

Gene Ontology (GO) - Cellular Components for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 16335786
genes like me logo Genes that share ontologies with RNF10: view

Pathways for RNF10 Gene

SuperPathways for RNF10 Gene

No Data Available

Interacting Proteins for RNF10 Gene

Gene Ontology (GO) - Biological Process for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010626 negative regulation of Schwann cell proliferation ISS --
GO:0031643 positive regulation of myelination ISS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 16335786
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with RNF10: view

No data available for Pathways by source for RNF10 Gene

Transcripts for RNF10 Gene

Unigene Clusters for RNF10 Gene

Ring finger protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNF10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - -
SP9: - - - -
SP10:
SP11:
SP12:
SP13: - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - -

ExUns: 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4: - -
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RNF10 Gene

GeneLoc Exon Structure for
RNF10
ECgene alternative splicing isoforms for
RNF10

Expression for RNF10 Gene

mRNA expression in normal human tissues for RNF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF10 Gene

This gene is overexpressed in Whole Blood (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNF10 Gene

SOURCE GeneReport for Unigene cluster for RNF10 Gene Hs.442798

genes like me logo Genes that share expressions with RNF10: view

Orthologs for RNF10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF10 36
  • 99.71 (n)
  • 99.63 (a)
RNF10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF10 36
  • 93.37 (n)
  • 93.83 (a)
RNF10 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 83 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
RNF10 36
  • 93.8 (n)
  • 94.54 (a)
mouse
(Mus musculus)
Mammalia Rnf10 36
  • 91.42 (n)
  • 92.79 (a)
Rnf10 16
Rnf10 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF10 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
-- 37
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rnf10 36
  • 91.06 (n)
  • 93.27 (a)
chicken
(Gallus gallus)
Aves RNF10 36
  • 75.11 (n)
  • 75.83 (a)
RNF10 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF10 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22040 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75603 36
rnf10 36
  • 66.25 (n)
  • 65.2 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9616 36
zebrafish
(Danio rerio)
Actinopterygii rnf10 36
  • 63.37 (n)
  • 61.95 (a)
rnf10 37
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007954 36
  • 49.45 (n)
  • 40.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12099 36
  • 47.79 (n)
  • 39.38 (a)
CG12099 37
  • 35 (a)
OneToOne
CG12099 38
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAG2 37
  • 24 (a)
OneToOne
MAG2 39
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4621 37
  • 36 (a)
OneToOne
Species with no ortholog for RNF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF10 Gene

ENSEMBL:
Gene Tree for RNF10 (if available)
TreeFam:
Gene Tree for RNF10 (if available)

Paralogs for RNF10 Gene

Pseudogenes.org Pseudogenes for RNF10 Gene

genes like me logo Genes that share paralogs with RNF10: view

No data available for Paralogs for RNF10 Gene

Variants for RNF10 Gene

Sequence variations from dbSNP and Humsavar for RNF10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10056 -- 120,576,600(+) AAGGN(G/T)GAAAG reference, frameshift-variant, nc-transcript-variant
rs10505 -- 120,576,998(-) CTGCT(A/C)TAATG utr-variant-3-prime, nc-transcript-variant
rs488313 -- 120,573,203(-) tatta(A/C/G/T)tgtgg intron-variant
rs489854 -- 120,567,862(+) ATGGg(G/T)gtgtg intron-variant
rs492574 -- 120,568,155(-) CCATC(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNF10 Gene

Variant ID Type Subtype PubMed ID
nsv906 CNV Loss 18451855
esv2746473 CNV Deletion 23290073

Relevant External Links for RNF10 Gene

HapMap Linkage Disequilibrium report
RNF10

Disorders for RNF10 Gene

No disorders were found for RNF10 Gene.

No data available for UniProtKB/Swiss-Prot for RNF10 Gene

Publications for RNF10 Gene

  1. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. (PMID: 10697961) Seki N. … Saito T. (J. Hum. Genet. 2000) 3 4 23
  2. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J. … Wigle J.T. (Mol. Cell. Biochem. 2005) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RNF10 Gene

Sources for RNF10 Gene

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