Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF10 Gene

Aliases for RNF10 Gene

  • Ring Finger Protein 10 2 3 5
  • RIE2 3 4
  • KIAA0262 4

External Ids for RNF10 Gene

Previous GeneCards Identifiers for RNF10 Gene

  • GC12P119852
  • GC12P120755
  • GC12P119384
  • GC12P119434
  • GC12P120972
  • GC12P117981

Summaries for RNF10 Gene

Entrez Gene Summary for RNF10 Gene

  • The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF10 Gene

RNF10 (Ring Finger Protein 10) is a Protein Coding gene. Diseases associated with RNF10 include Charcot-Marie-Tooth Disease, Axonal, Type 2L. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot for RNF10 Gene

  • Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Wiki entry for RNF10 Gene

Additional gene information for RNF10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF10 Gene

Genomics for RNF10 Gene

GeneHancer (GH) Regulatory Elements for RNF10 Gene

Promoters and enhancers for RNF10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I120533 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 552.4 +3.8 3813 7.1 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 RNF10 GC12P120535 COQ5 GATC POP5 RPL31P52 TRIAP1 ENSG00000111780 SPPL3 ACADS
GH12I120494 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.6 -36.9 -36879 3.5 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 E2F8 DYNLL1 GC12P120497 NRAV COQ5 GATC RPL29P24 RNF10 SRSF9 RPL31P52 TRIAP1
GH12I120437 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.4 -95.2 -95223 1.8 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B COX6A1 ENSG00000111780 GC12P120439 COQ5 GATC RNF10
GH12I120223 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.6 -301.9 -301895 16 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 PXN SIRT4 RPLP0 RNU4-1 RNU4-2 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
GH12I120498 Enhancer 0.5 ENCODE 12.4 -34.3 -34301 0.5 PAF1 POLR2A ZNF189 FEZF1 ZNF18 ENSG00000278344 GC12P120497 GATC RPL29P24 RNF10 COQ5 RPL31P52 TRIAP1 ENSG00000111780 COX6A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF10 gene promoter:

Genomic Locations for RNF10 Gene

Genomic Locations for RNF10 Gene
chr12:120,533,480-120,577,594
(GRCh38/hg38)
Size:
44,115 bases
Orientation:
Plus strand
chr12:120,971,283-121,015,397
(GRCh37/hg19)

Genomic View for RNF10 Gene

Genes around RNF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF10 Gene

Proteins for RNF10 Gene

  • Protein details for RNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5U6-RNF10_HUMAN
    Recommended name:
    RING finger protein 10
    Protein Accession:
    Q8N5U6
    Secondary Accessions:
    • Q92550
    • Q9NPP8
    • Q9ULW4

    Protein attributes for RNF10 Gene

    Size:
    811 amino acids
    Molecular mass:
    89927 Da
    Quaternary structure:
    • Interacts with MEOX2.

    Alternative splice isoforms for RNF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF10 Gene

Post-translational modifications for RNF10 Gene

  • Ubiquitination at isoforms=2105, isoforms=2136, isoforms=2137, Lys167, isoforms=2236, and isoforms=2337

No data available for DME Specific Peptides for RNF10 Gene

Domains & Families for RNF10 Gene

Gene Families for RNF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF10 Gene

Suggested Antigen Peptide Sequences for RNF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N5U6

UniProtKB/Swiss-Prot:

RNF10_HUMAN :
  • Belongs to the RNF10 family.
Family:
  • Belongs to the RNF10 family.
genes like me logo Genes that share domains with RNF10: view

Function for RNF10 Gene

Molecular function for RNF10 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Phenotypes From GWAS Catalog for RNF10 Gene

Gene Ontology (GO) - Molecular Function for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 16335786
GO:0044212 transcription regulatory region DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF10: view
genes like me logo Genes that share phenotypes with RNF10: view

Animal Models for RNF10 Gene

MGI Knock Outs for RNF10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF10 Gene

Localization for RNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF10 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA,IEA 16335786
genes like me logo Genes that share ontologies with RNF10: view

Pathways & Interactions for RNF10 Gene

SuperPathways for RNF10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010626 negative regulation of Schwann cell proliferation ISS --
GO:0031643 positive regulation of myelination ISS --
GO:0045893 positive regulation of transcription, DNA-templated IDA 16335786
genes like me logo Genes that share ontologies with RNF10: view

No data available for Pathways by source and SIGNOR curated interactions for RNF10 Gene

Drugs & Compounds for RNF10 Gene

No Compound Related Data Available

Transcripts for RNF10 Gene

Unigene Clusters for RNF10 Gene

Ring finger protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - -
SP9: - - - -
SP10:
SP11:
SP12:
SP13: - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - -

ExUns: 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4: - -
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RNF10 Gene

GeneLoc Exon Structure for
RNF10
ECgene alternative splicing isoforms for
RNF10

Expression for RNF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF10 Gene

This gene is overexpressed in Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for RNF10 Gene

This gene is overexpressed in Adipocyte (48.4) and Placenta (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF10 Gene



Protein tissue co-expression partners for RNF10 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF10 Gene:

RNF10

SOURCE GeneReport for Unigene cluster for RNF10 Gene:

Hs.442798

Evidence on tissue expression from TISSUES for RNF10 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Eye(4.5)
  • Bone marrow(4.4)
  • Lung(3.9)
  • Kidney(3.7)
  • Intestine(3.4)
  • Skin(3.2)
  • Blood(2.9)
  • Spleen(2.7)
  • Heart(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with RNF10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF10 Gene

Orthologs for RNF10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF10 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNF10 33
  • 93.8 (n)
-- 34
  • 83 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RNF10 34 33
  • 93.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf10 33 16 34
  • 91.42 (n)
rat
(Rattus norvegicus)
Mammalia Rnf10 33
  • 91.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RNF10 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF10 34 33
  • 75.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF10 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf10 33
  • 66.25 (n)
MGC75603 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.22040 33
zebrafish
(Danio rerio)
Actinopterygii rnf10 34 33
  • 63.37 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9616 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007954 33
  • 49.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12099 35 33 34
  • 47.79 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAG2 34 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4621 34
  • 36 (a)
OneToOne
Species where no ortholog for RNF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF10 Gene

ENSEMBL:
Gene Tree for RNF10 (if available)
TreeFam:
Gene Tree for RNF10 (if available)

Paralogs for RNF10 Gene

Pseudogenes.org Pseudogenes for RNF10 Gene

genes like me logo Genes that share paralogs with RNF10: view

No data available for Paralogs for RNF10 Gene

Variants for RNF10 Gene

Sequence variations from dbSNP and Humsavar for RNF10 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000027673 -- 120,535,007(+) C/T intron_variant
rs1000171510 -- 120,563,320(+) C/G intron_variant
rs1000206811 -- 120,554,160(+) C/T intron_variant
rs1000426729 -- 120,548,559(+) G/A intron_variant
rs1000494847 -- 120,571,088(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF10 Gene

Variant ID Type Subtype PubMed ID
esv2746473 CNV deletion 23290073
esv3630927 CNV loss 21293372
nsv906 CNV deletion 18451855

Variation tolerance for RNF10 Gene

Residual Variation Intolerance Score: 3.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF10 Gene

Disorders for RNF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2l
  • cmt2l
- elite association - COSMIC cancer census association via MalaCards
Search RNF10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RNF10

genes like me logo Genes that share disorders with RNF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF10 Gene

Publications for RNF10 Gene

  1. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J … Wigle JT (Molecular and cellular biochemistry 2005) 3 4 22 58
  2. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. (PMID: 10697961) Seki N … Saito T (Journal of human genetics 2000) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 58
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 58

Products for RNF10 Gene

Sources for RNF10 Gene

Content
Loading form....