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Aliases for RND3 Gene

Aliases for RND3 Gene

  • Rho Family GTPase 3 2 3 4
  • RhoE 3 4 6
  • ARHE 3 4 6
  • Rho-Related GTP-Binding Protein Rho8 3 4
  • Ras Homolog Gene Family, Member E 2 3
  • Protein MemB 3 4
  • Rho8 3 4
  • Rho-Related GTP-Binding Protein RhoE 3
  • Small GTP Binding Protein Rho8 3
  • MemB 3
  • Rnd3 4

External Ids for RND3 Gene

Previous Symbols for RND3 Gene

  • ARHE

Summaries for RND3 Gene

Entrez Gene Summary for RND3 Gene

  • This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for RND3 Gene

RND3 (Rho Family GTPase 3) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Akt Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RND3 Gene

  • Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins

Gene Wiki entry for RND3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RND3 Gene

Genomics for RND3 Gene

Genomic Location for RND3 Gene

Start:
150,468,193 bp from pter
End:
150,539,011 bp from pter
Size:
70,819 bases
Orientation:
Minus strand

Genomic View for RND3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RND3 Gene

Regulatory Elements for RND3 Gene

Proteins for RND3 Gene

  • Protein details for RND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61587-RND3_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoE
    Protein Accession:
    P61587
    Secondary Accessions:
    • D3DP95
    • P52199

    Protein attributes for RND3 Gene

    Size:
    244 amino acids
    Molecular mass:
    27368 Da
    Quaternary structure:
    • Binds ROCK1 (By similarity). Interacts with UBXD5.

    Three dimensional structures from OCA and Proteopedia for RND3 Gene

neXtProt entry for RND3 Gene

Proteomics data for RND3 Gene at MOPED

Post-translational modifications for RND3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RND3 Gene

No data available for DME Specific Peptides for RND3 Gene

Domains for RND3 Gene

Suggested Antigen Peptide Sequences for RND3 Gene

Graphical View of Domain Structure for InterPro Entry

P61587

UniProtKB/Swiss-Prot:

RND3_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • P61587
genes like me logo Genes that share domains with RND3: view

No data available for Gene Families for RND3 Gene

Function for RND3 Gene

Molecular function for RND3 Gene

UniProtKB/Swiss-Prot Function: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins

Gene Ontology (GO) - Molecular Function for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8649376
GO:0005515 protein binding IPI 23622247
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RND3: view
genes like me logo Genes that share phenotypes with RND3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RND3 Gene

Localization for RND3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND3 Gene

Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RND3 Gene COMPARTMENTS Subcellular localization image for RND3 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
cytoskeleton 2
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005794 Golgi apparatus --
GO:0005925 focal adhesion IDA 21423176
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RND3: view

Pathways for RND3 Gene

genes like me logo Genes that share pathways with RND3: view

Pathways by source for RND3 Gene

1 Cell Signaling Technology pathway for RND3 Gene

Gene Ontology (GO) - Biological Process for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007155 cell adhesion TAS 9531558
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008152 metabolic process TAS 8649376
genes like me logo Genes that share ontologies with RND3: view

Compounds for RND3 Gene

(1) HMDB Compounds for RND3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Drugbank Compounds for RND3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Triphosphate
86-01-1 target

(4) Novoseek inferred chemical compound relationships for RND3 Gene

Compound -log(P) Hits PubMed IDs
gtp 65.9 7
actomyosin 52.2 1
threonine 41.7 2
serine 27.9 2
genes like me logo Genes that share compounds with RND3: view

Transcripts for RND3 Gene

Unigene Clusters for RND3 Gene

Rho family GTPase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RND3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for RND3 Gene

GeneLoc Exon Structure for
RND3
ECgene alternative splicing isoforms for
RND3

Expression for RND3 Gene

mRNA expression in normal human tissues for RND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RND3 Gene

SOURCE GeneReport for Unigene cluster for RND3 Gene Hs.6838

mRNA Expression by UniProt/SwissProt for RND3 Gene

P61587-RND3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with RND3: view

No data available for mRNA differential expression in normal tissues for RND3 Gene

Orthologs for RND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RND3 35
  • 100 (n)
  • 100 (a)
RND3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RND3 35
  • 93.58 (n)
  • 100 (a)
RND3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC483917 35
  • 89.48 (n)
  • 99.59 (a)
RND3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnd3 35
  • 93.03 (n)
  • 100 (a)
Rnd3 16
Rnd3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RND3 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RND3 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnd3 35
  • 92.35 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RND3 35
  • 85.66 (n)
  • 97.95 (a)
RND3 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RND3 36
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4080 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnd3 35
  • 81.69 (n)
  • 95.9 (a)
Str.17125 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8918 35
zebrafish
(Danio rerio)
Actinopterygii idibd2919 35
rnd3a 35
  • 78.05 (n)
  • 90.53 (a)
rnd3a 36
  • 91 (a)
OneToMany
rnd3b 36
  • 78 (a)
OneToMany
Species with no ortholog for RND3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RND3 Gene

ENSEMBL:
Gene Tree for RND3 (if available)
TreeFam:
Gene Tree for RND3 (if available)

Paralogs for RND3 Gene

Paralogs for RND3 Gene

Selected SIMAP similar genes for RND3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RND3: view

Variants for RND3 Gene

Sequence variations from dbSNP and Humsavar for RND3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs707119 -- 150,473,154(+) AAAAA(A/G)AAAGA intron-variant
rs707123 -- 150,472,479(+) AACAA(G/T)AATTA intron-variant
rs816889 -- 150,468,781(+) GCTGC(A/G)TCTGT utr-variant-3-prime
rs816890 -- 150,471,193(+) TTTAT(A/G)AGAAT intron-variant
rs953278 -- 150,481,224(-) GCCAC(A/C)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RND3 Gene

Variant ID Type Subtype PubMed ID
nsv834414 CNV Gain 17160897

Relevant External Links for RND3 Gene

HapMap Linkage Disequilibrium report
RND3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RND3 Gene

Disorders for RND3 Gene

(1) Novoseek inferred disease relationships for RND3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4

Relevant External Links for RND3

Genetic Association Database (GAD)
RND3
genes like me logo Genes that share disorders with RND3: view

No data available for UniProtKB/Swiss-Prot for RND3 Gene

Publications for RND3 Gene

  1. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. (PMID: 8649376) Foster R. … Settleman J. (Mol. Cell. Biol. 1996) 2 3 4 23
  2. RhoE binds to ROCK I and inhibits downstream signaling. (PMID: 12773565) Riento K. … Ridley A.J. (Mol. Cell. Biol. 2003) 3 23
  3. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. (PMID: 12842009) Wennerberg K. … Hansen S.H. (Curr. Biol. 2003) 3 23
  4. Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis. (PMID: 15754346) Bektic J. … Klocker H. (Prostate 2005) 3 23
  5. RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. (PMID: 17174923) Ongusaha P.P. … Lee S.W. (Curr. Biol. 2006) 3 23

Products for RND3 Gene

  • Addgene plasmids for RND3

Sources for RND3 Gene

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