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RND3 Gene

protein-coding   GIFtS: 62
GCID: GC02M151324

Rho Family GTPase 3

(Previous names: ras homolog gene family, member E)
(Previous symbol: ARHE)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Family GTPase 31 2 3     RhoE2
ARHE1 2 3 5     memB2
Ras Homolog Gene Family, Member E1 2     Rho-Related GTP-Binding Protein RhoE2
Protein MemB2 3     Small GTP Binding Protein Rho82
Rho-Related GTP-Binding Protein Rho82 3     RHO83
RHOE3 5     Rnd33
Rho82     

External Ids:    HGNC: 6711   Entrez Gene: 3902   Ensembl: ENSG000001159637   OMIM: 6029245   UniProtKB: P615873   

Export aliases for RND3 gene to outside databases

Previous GC identifers: GC02M151151 GC02M151032 GC02M143221


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RND3 Gene:
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds
only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization
leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been
identified. (provided by RefSeq, Dec 2011)

GeneCards Summary for RND3 Gene:
RND3 (Rho family GTPase 3) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RND3_HUMAN, P61587
Function: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating
proteins

Gene Wiki entry for RND3 (Rnd3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RND3 gene promoter:
         AhR   Max1   USF1   p300   USF2   Arnt   YY1   PPAR-alpha   IRF-7A   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRND3 promoter sequence
   Search Chromatin IP Primers for RND3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RND3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3   Ensembl cytogenetic band:  2q23.3   HGNC cytogenetic band: 2q23.3

RND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RND3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M151324:  view genomic region     (about GC identifiers)

Start:
151,324,709 bp from pter      End:
151,395,525 bp from pter
Size:
70,817 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RND3_HUMAN, P61587 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoE precursor  
Size: 244 amino acids; 27368 Da
Subunit: Binds ROCK1 (By similarity). Interacts with UBXD5
3 PDB 3D structures from and Proteopedia for RND3:
1M7B (3D)        2V55 (3D)        4BG6 (3D)    
Secondary accessions: D3DP95 P52199

Explore the universe of human proteins at neXtProt for RND3: NX_P61587

Explore proteomics data for RND3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RND3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001241667.1  NP_005159.1  

    ENSEMBL proteins: 
     ENSP00000364886   ENSP00000263895   ENSP00000386576   ENSP00000411950   ENSP00000395997  

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    Cloud-Clone Corp. Proteins for RND3

     
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    RND3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RND3
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR003578 Small_GTPase_Rho

    Graphical View of Domain Structure for InterPro Entry P61587

    ProtoNet protein and cluster: P61587

    2 Blocks protein domains:
    IPB003577 Ras small GTPase
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RND3_HUMAN, P61587
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Find genes that share domains with RND3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RND3_HUMAN, P61587
    Function: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating
    proteins

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8649376
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with RND3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RND3:
     Decreased focal adhesion (FA)  

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rnd3):
     behavior/neurological  craniofacial  growth/size/body  hearing/vestibular/ear  mortality/aging 
     muscle  nervous system  skeleton  vision/eye 

    Find genes that share phenotypes with RND3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RND3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RND3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RND3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RND3

    miRNA
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    miRTarBase miRNAs that target RND3:
    hsa-mir-17-5p (MIRT006689), hsa-mir-200b-3p (MIRT006511), hsa-mir-93-5p (MIRT027956), hsa-mir-98-5p (MIRT027467), hsa-mir-421 (MIRT016130), hsa-mir-30a-5p (MIRT028467)

    Block miRNA regulation of human, mouse, rat RND3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RND3 (see all 36):
    hsa-miR-3678-3p hsa-miR-4307 hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-miR-429 hsa-miR-106a hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidRND3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RND3
    Predesigned siRNA for gene silencing in human, mouse, rat RND3

    Gene Editing
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    Sino Biological Human cDNA Clone for RND3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND3
    Addgene plasmids for RND3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RND3_HUMAN, P61587: Golgi apparatus membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol3
    cytoskeleton2
    extracellular2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0016020membrane ----

    Find genes that share ontologies with RND3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RND3 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of p53
    Selected targets of p53
    2Selected targets of CREB1
    Selected targets of CREB1
    3Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with RND3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RND3 (see all 33)
        Fc-GammaR Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Tec Kinases Signaling
    Crosstalk Between CARM1 and ESRs

    1 Cell Signaling Technology (CST) Pathway for RND3
        Cytoskeletal Signaling



        Pathway & Disease-focused RT2 Profiler PCR Array including RND3: 
              Cell Motility in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RND3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for RND3 (P615871, 2, 3 ENSP000002638954) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974807 I2D: score=2 
    ARHGAP5Q130173, ENSP000003718974I2D: score=3 STRING: ENSP00000371897
    PLXNB1O431573, ENSP000002964404I2D: score=3 STRING: ENSP00000296440
    ROCK1Q134643, ENSP000003826974I2D: score=5 STRING: ENSP00000382697
    UBXN11Q5T1243, ENSP000003633384I2D: score=2 STRING: ENSP00000363338
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    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8649376
    GO:0007155cell adhesion TAS9531558
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    Find genes that share ontologies with RND3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RND3

    1 HMDB Compound for RND3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for RND3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Triphosphate-- 86-01-1target--17139284 17016423 10592235

    4 Novoseek inferred chemical compound relationships for RND3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 65.9 9 8649376 (2), 15340047 (1), 12842009 (1), 12009891 (1) (see all 6)
    actomyosin 52.2 1 16472685 (1)
    threonine 41.7 2 16042565 (1), 16472685 (1)
    serine 27.9 2 16042565 (1), 16472685 (1)



    Find genes that share compounds with RND3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RND3 gene (2 alternative transcripts): 
    NM_001254738.1  NM_005168.4  

    Unigene Cluster for RND3:

    Rho family GTPase 3
    Hs.6838  [show with all ESTs]
    Unigene Representative Sequence: NM_001254738
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375734(uc002txe.3) ENST00000263895(uc002txg.3 uc010zbv.2)
    ENST00000409557 ENST00000497865 ENST00000473639 ENST00000466334 ENST00000472416
    ENST00000454202 ENST00000439275
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RND3 (see all 36):
    hsa-miR-3678-3p hsa-miR-4307 hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-miR-429 hsa-miR-106a hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidRND3 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for RND3 
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      QuantiTect SYBR Green Assays in human, mouse, rat RND3
      QuantiFast Probe-based Assays in human, mouse, rat RND3

    Additional mRNA sequence: 

    AF498969.1 AK298007.1 AK299731.1 AK309442.1 AK311312.1 AK313224.1 BC012513.1 BT006769.1 
    CR542038.1 CR542070.1 S82240.1 X95282.1 X97758.1 

    11 DOTS entries:

    DT.217787  DT.100790522  DT.87077945  DT.92430361  DT.100790521  DT.120995062  DT.217788  DT.100790524 
    DT.100809811  DT.120995060  DT.95300953 

    Selected AceView cDNA sequences (see all 223):

    BQ720259 BQ434193 BQ879015 CR597613 F12790 AA587167 CF594049 BG314741 
    AI537513 CB960665 CR626467 CN485192 AU280574 CR542070 X95282 CN484360 
    BM763305 CB266344 BP339154 CR607069 AF498969 AI818033 BQ440721 CB305755 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RND3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                    -           -                                       
    SP2:                    -           -                                       
    SP3:                                -                                       
    SP4:                                                                        


    ECgene alternative splicing isoforms for RND3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RND3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTGTCTA
    RND3 Expression
    About this image


    RND3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             CyT49
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    RND3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RND3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6838

    UniProtKB/Swiss-Prot: RND3_HUMAN, P61587
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including RND3: 
              Cell Motility in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RND3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RND3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnd31 , 5 Rho family GTPase 31, 5 93.03(n)1
    100(a)1
      2 (29.63 cM)5
    741941  NM_028810.21  NP_083086.11 
     511304385 
    chicken
    (Gallus gallus)
    Aves RND31 Rho family GTPase 3 85.66(n)
    97.95(a)
      424312  XM_422158.4  XP_422158.2 
    lizard
    (Anolis carolinensis)
    Reptilia RND36
    Rho family GTPase 3
    93(a)
    1 ↔ 1
    GL343302.1(712697-743258)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.40802 Xenopus laevis transcribed sequence with strong similarity more 80.21(n)    BU914678.1 
    zebrafish
    (Danio rerio)
    Actinopterygii idibd29192 idibd2919 81.05(n)   80963  BC059452.1 


    ENSEMBL Gene Tree for RND3 (if available)
    TreeFam Gene Tree for RND3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RND3 gene
    RHOB2  RND12  RHOA2  RHOD2  RHOF2  ENSG000002718102  RHOC2  RND22  
    Selected SIMAP similar genes for RND3 using alignment to 4 protein entries:     RND3_HUMAN (see all proteins) (see all similar genes):
    ARHE    RND2    RHOA    RND1    RHOC    RHOB
    ARHA    RHOD    ARHG    RHOG    RHOF    RHOQ
    RHOJ    RAC3    CDC42    RHOU    RAC2    RAC1

    Find genes that share paralogs with RND3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RND3 (see all 392)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs752301891,2
    C,F--151324238(+) TCCACG/AAATTG 2 -- ds50011Minor allele frequency- A:0.02EA 120
    rs1131281531,2
    C--151324343(+) CCACAG/CGGCAG 2 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs64327741,2
    C,F,A,H--151324400(+) TGCATC/TATATT 2 -- ds500135Minor allele frequency- T:0.16NA NS EA WA CSA 3338
    rs1888977531,2
    --151324637(+) AGATTA/CTGTAA 2 -- ds50010--------
    rs1929124511,2
    --151324641(+) TCTGTA/TATCAC 2 -- ds50010--------
    rs13724381,2
    C,F,A,H--151324688(+) AAGTAG/TATAAT 2 -- ds500125Minor allele frequency- T:0.15NA NS EA CSA WA 2668
    rs58352991,2
    C--151324743(+) AAAAAA/-GTATG 1 -- ut31 trp32Minor allele frequency- -:0.00NA CSA 4
    rs1482641671,2
    C--151324747(+) GAAAA-/A/GAAAAA 4 -- ut310--------
    rs1474392771,2
    --151324848(+) TATAAC/TAGTTA 2 -- ut310--------
    rs1842348021,2
    --151324896(+) GCACTC/TGCCAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RND3 (151324709 - 151395525 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RND3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834414CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RND3
    DNA2.0 Custom Variant and Variant Library Synthesis for RND3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602924    OMIM disorders: --


    Find genes that share disorders with RND3           About GenesLikeMe

    1 Novoseek inferred disease relationship for RND3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 17312384 (1), 17182035 (1), 15754346 (1), 19244113 (1)

    Genetic Association Database (GAD): RND3

    Export disorders for RND3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RND3 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with RND3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. (PubMed id 8649376)1, 2, 3, 9 Foster R.... Settleman J. (Mol. Cell. Biol. 1996)
    2. A genome-wide association search for type 2 diabetes genes in African Americans. (PubMed id 22238593)1, 4 Palmer N.D....Sladek R. (PLoS ONE 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Crystal structure of Rnd3/RhoE: functional implications. (PubMed id 12163169)1, 2 Fiegen D.... Ahmadian M.R. (FEBS Lett. 2002)
    5. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PubMed id 11940653)1, 2 Katoh H.... Negishi M. (Mol. Cell. Biol. 2002)
    6. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PubMed id 9531558)1, 2 Nobes C.D.... Chardin P. (J. Cell Biol. 1998)
    7. Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. (PubMed id 19244113)1, 9 Klein R.M. and Aplin A.E. (Cancer Res. 2009)
    8. RhoE binds to ROCK I and inhibits downstream signaling. (PubMed id 12773565)1, 9 Riento K.... Ridley A.J. (Mol. Cell. Biol. 2003)
    9. RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line. (PubMed id 17182035)1, 9 Poch E....Guasch R.M. (Exp. Cell Res. 2007)
    10. RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. (PubMed id 19850923)1, 9 Villalonga P....Ridley A.J. (J. Biol. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 390 HGNC: 671 AceView: ARHE Ensembl:ENSG00000115963 euGenes: HUgn390
    ECgene: RND3 H-InvDB: RND3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RND3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RND3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RND3 gene:
    Search GeneIP for patents involving RND3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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