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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RND3 Gene

protein-coding GIFtS: 60
GCID: GC02M151324

Rho family GTPase 3

(Previous names: ras homolog gene family, member E )
(Previous symbol: ARHE)

Explore 9 diseases affiliated with
RND3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rho Family GTPase 3¹ ² ³		MemB¹
ARHE¹ ² ³		Rho-Related GTP-Binding Protein RhoE²
Rho8¹ ²		Small GTP Binding Protein Rho8²
RhoE¹ ²		RHO8³
Ras Homolog Gene Family, Member E¹ ²		RHOE³
Protein MemB² ³		Rnd3³
Rho-Related GTP-Binding Protein Rho8² ³

External Ids:	HGNC: 671¹	Entrez Gene: 390²	Ensembl: ENSG00000115963⁷	OMIM: 602924⁵	UniProtKB: P61587³

Export aliases for RND3 gene to outside databases

Previous GC identifers: GC02M151151 GC02M151032 GC02M143221

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RND3:

This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only

GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to

loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. (provided

by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: RND3_HUMAN, P61587

Function: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins

Gene Wiki entry for RND3 (Rnd3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RND3 gene promoter:
AhR Max1 USF1 p300 USF2 Arnt YY1 PPAR-alpha IRF-7A En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RND3 promoter sequence

Search SABiosciences Chromatin IP Primers for RND3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RND3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q23.3 Ensembl cytogenetic band: 2q23.3 HGNC cytogenetic band: 2q23.3

RND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RND3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M151324: view genomic region (about GC identifiers)

Start:	151,324,709 bp from pter	End:	151,395,525 bp from pter
Size:	70,817 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RND3_HUMAN, P61587 (See protein sequence)

Recommended Name: Rho-related GTP-binding protein RhoE precursor

Size: 244 amino acids; 27368 Da

Subunit: Binds ROCK1 (By similarity). Interacts with UBXD5

Subcellular location: Golgi apparatus membrane; Peripheral membrane protein

2 PDB 3D structures from and Proteopedia for RND3:

1M7B (3D)

2V55 (3D)

Secondary accessions: D3DP95 P52199

Explore the universe of human proteins at neXtProt for RND3: NX_P61587

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61587

RND3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001241667.1 NP_005159.1

ENSEMBL proteins:

ENSP00000263895 ENSP00000364886 ENSP00000386576 ENSP00000395997 ENSP00000411950

Human Recombinant Protein Products for RND3:

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	Uscn Proteins for RND3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005622	intracellular	--	--
GO:0016020	membrane	--	--

RND3 for ontologies About GeneDecksing

RND3 Antibody Products:

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	Uscn ELISAs and CLIAs for RND3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RND3 for domains About GeneDecksing

3 InterPro domains/families:

IPR003578 Small_GTPase_Rho

IPR005225 Small_GTP-bd_dom

IPR001806 Small_GTPase

Graphical View of Domain Structure for InterPro Entry P61587

ProtoNet protein and cluster: P61587

2 Blocks protein families:

IPB003577 Ras small GTPase

IPB003578 Ras small GTPase

UniProtKB/Swiss-Prot: RND3_HUMAN, P61587

Similarity: Belongs to the small GTPase superfamily. Rho family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RND3_HUMAN, P61587

Function: Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	TAS	8649376
GO:0005525	GTP binding	IEA	--

RND3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RND3:

Decreased focal adhesion (FA)

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rnd3):

behavior/neurological	growth/size	hearing/vestibular/ear	mortality/aging	muscle
nervous system	vision/eye

RND3 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RND3

miRNA Products:		OriGene 3'-UTR Clone: RND3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RND3
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate RND3 (see all 36):
		hsa-miR-3678-3p hsa-miR-4307 hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-miR-429 hsa-miR-106a hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: RND3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RND3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RND3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

Selected targets of CREB1

Selected targets of CREB1

1.00

Selected targets of p53

Selected targets of p53

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for RND3

	Selected targets of CREB1
	Selected targets of p53

1 Cell Signaling Technology (CST) Pathway for RND3

Cytoskeletal Signaling

RND3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RND3

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/7 Interacting proteins for RND3 (P61587^{2, 3} ENSP00000263895⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³	MINT-3974807 I2D: score=2
ARHGAP5	Q13017³, ENSP00000371897⁴	I2D: score=3 STRING: ENSP00000371897
PLXNB1	O43157³, ENSP00000296440⁴	I2D: score=3 STRING: ENSP00000296440
ROCK1	Q13464³, ENSP00000382697⁴	I2D: score=5 STRING: ENSP00000382697
UBXN11	Q5T124³, ENSP00000363338⁴	I2D: score=2 STRING: ENSP00000363338

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006184	GTP catabolic process	TAS	8649376
GO:0007155	cell adhesion	TAS	9531558
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0030036	actin cytoskeleton organization	TAS	9531558

RND3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RND3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RND3

1 HMDB Compound for RND3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

1 DrugBank Compound for RND3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Guanosine-5'-Triphosphate	--	86-01-1	target	--	17139284 17016423 10592235

4 Novoseek chemical compound relationships for RND3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	65.9	9	8649376 (2), 15340047 (1), 12842009 (1), 12009891 (1) (see all 6)
actomyosin	52.2	1	16472685 (1)
threonine	41.7	2	16042565 (1), 16472685 (1)
serine	27.9	2	16042565 (1), 16472685 (1)

Search CenterWatch for drugs/clinical trials and news about RND3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RND3 gene (2 alternative transcripts):

NM_001254738.1 NM_005168.4

Unigene Cluster for RND3:

Rho family GTPase 3

Hs.6838 [show with all ESTs]

Unigene Representative Sequence: NM_001254738

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000263895(uc002txg.3 uc010zbv.2) ENST00000375734(uc002txe.3)

ENST00000409557 ENST00000497865 ENST00000473639 ENST00000466334 ENST00000472416

ENST00000439275 ENST00000454202

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RND3
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate RND3 (see all 36):
		hsa-miR-3678-3p hsa-miR-4307 hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-miR-429 hsa-miR-106a hsa-miR-128

		SwitchGear 3'UTR luciferase reporter plasmid: RND3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AF498969.1 AK298007.1 AK299731.1 AK309442.1 AK311312.1 AK313224.1 BC012513.1 BT006769.1

CR542038.1 CR542070.1 S82240.1 X95282.1 X97758.1

14 DOTS entries:

DT.217787 DT.100790522 DT.87077945 DT.92430361 DT.120995062 DT.100790521 DT.217788 DT.95358186

DT.100790524 DT.100809811 DT.120995060 DT.120995067 DT.92430363 DT.95300953

24/223 AceView cDNA sequences (see all 223):

CN484360 X95282 CR597613 CN485192 AI537513 CB266344 CR607069 AF498969

BQ720259 BQ879015 AU280574 CR626467 CR542070 BG314741 F12790 CF594049

AA587167 CB960665 BM763305 BP339154 BQ434193 AI569594 AU120255 AW073733

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RND3 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d
SP1:							-				-
SP2:							-				-
SP3:											-
SP4:

ECgene alternative splicing isoforms for RND3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RND3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTGTCTA

About this image

RND3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RND3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RND3

SOURCE GeneReport for Unigene cluster: Hs.6838

UniProtKB/Swiss-Prot: RND3_HUMAN, P61587

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Array including RND3:

Cell Motility in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RND3 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RND3¹	Rho family GTPase 3	85.66(n) 97.95(a)		424312 XM_422158.3 XP_422158.2
lizard (Anolis carolinensis)	Reptilia	RND3⁶	--	97(a)	1 ↔ 1	GL343302.1(714678-743222)
African clawed frog (Xenopus laevis)	Amphibia	Xl.4080²	Xenopus laevis transcribed sequence with strong similarity more	80.21(n)		BU914678.1
zebrafish (Danio rerio)	Actinopterygii	idibd2919²	idibd2919	81.05(n)		80963 BC059452.1

ENSEMBL Gene Tree for RND3 (if available)
TreeFam Gene Tree for RND3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RND3 gene

RHOB² RND1² RHOD² RHOA² RHOF² RHOC²

18/26 SIMAP similar genes for RND3 using alignment to 4 protein entries: RND3_HUMAN (see all proteins) (see all similar genes):

ARHE RND2 RHOA RND1 RHOC RHOB

ARHA RHOD ARHG RHOG RHOF RHOQ

RHOJ RAC3 CDC42 RHOU RAC2 RAC1

RND3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75230189^1,2	F	--	151324238(+)	`TCCACG/AAATTG`	2	--	ds500¹		1		EA	120
rs6432774^1,2	C,F,A,H	--	151324400(+)	`TGCATC/TATATT`	2	--	ds500¹		35		NA NS EA WA CSA	3338
rs188897753^1,2		--	151324637(+)	`AGATTA/CTGTAA`	2	--	ds500¹		0	--	--	--	--
rs192912451^1,2		--	151324641(+)	`TCTGTA/TATCAC`	2	--	ds500¹		0	--	--	--	--
rs1372438^1,2	C,F,A,H	--	151324688(+)	`AAGTAG/TATAAT`	2	--	ds500¹		25		NA NS EA CSA WA	2668
rs11397259^1,2	C	--	151324741(+)	`TGAAGA/-AAAAA`	2	--	ut3¹ trp³		1		CSA	2
rs5835299^1,2	C	--	151324744(+)	`AAAAAA/-GTATG`	2	--	ut3¹ trp³		1		NA	2
rs147439277^1,2		--	151324848(+)	`TATAAC/TAGTTA`	2	--	ut3¹		0	--	--	--	--
rs184234802^1,2		--	151324896(+)	`GCACTC/TGCCAG`	2	--	ut3¹		0	--	--	--	--
rs75840107^1,2		--	151325025(+)	`AAGTGC/TTTGTA`	2	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for RND3 (151324709 - 151395525 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RND3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RND3

DNA2.0 Custom Variant and Variant Library Synthesis for RND3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RND3 for disorders           About GeneDecksing

OMIM gene information: 602924    OMIM disorders: --

9 diseases for RND3:    About MalaCards

colon cancer gastric cancer lung cancer prostate cancer

glioblastoma hypoxia prostatitis melanoma

carcinoma

1 Novoseek disease relationship for RND3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	4	17312384 (1), 17182035 (1), 15754346 (1), 19244113 (1)

Export disorders for RND3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RND3 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with RND3)

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Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. (PubMed id 8649376)^{1, 2, 3, 9} Foster R.... Settleman J. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Crystal structure of Rnd3/RhoE: functional implications. (PubMed id 12163169)^{1, 2} Fiegen D.... Ahmadian M.R. (2002)
Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PubMed id 11940653)^{1, 2} Katoh H.... Negishi M. (2002)
A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PubMed id 9531558)^{1, 2} Nobes C.D.... Chardin P. (1998)
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. (PubMed id 19244113)^{1, 9} Klein R.M. and Aplin A.E. (2009)
RhoE binds to ROCK I and inhibits downstream signaling. (PubMed id 12773565)^{1, 9} Riento K.... Ridley A.J. (2003)
RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line. (PubMed id 17182035)^{1, 9} Poch E....Guasch R.M. (2007)
RhoE inhibits 4E-BP1 phosphorylation and eIF4E functi on impairing cap-dependent translation. (PubMed id 19850923)^{1, 9} Villalonga P....Ridley A.J. (2009)
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. (PubMed id 17174923)^{1, 9} Ongusaha P.P....Lee S.W. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 390	HGNC: 671	AceView: ARHE	Ensembl:ENSG00000115963	euGenes: HUgn390
ECgene: RND3	H-InvDB: RND3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RND3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RND3 gene
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