RND3 Gene

Aliases
for RND3 gene

Previous GC identifers: GC02M151151 GC02M151032 GC02M143221

Summaries
for RND3 gene

Genomic Views
for RND3 gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_005403.17  

SwitchGear Promoter luciferase reporter plasmid: RND3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RND3

RND3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M151324:  view genomic region     (about GC identifiers)

Proteins
for RND3 gene

2 PDB 3D structures from and Proteopedia for RND3:

1M7B (3D)        2V55 (3D)    

Explore the universe of human proteins at neXtProt for RND3: NX_P61587

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: RND3 OriGene Protein Over-expression Lysate: RND3 OriGene Custom Protein Services for RND3
	GenScript Custom Purified and Recombinant Proteins Services for RND3
	Novus Biologicals RND3 Proteins Novus Biologicals RND3 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for RND3
	Uscn Proteins for RND3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RND3
	R&D Systems Antibodies for RND3
	Cell Signaling Technology (CST) Antibodies for RND3  (RhoE)
	Browse OriGene Antibodies OriGene Custom Antibody Services for RND3
	GenScript Custom Superior Antibodies Services for RND3
	Novus Biologicals RND3 Antibodies
	Abcam antibodies for RND3
	Uscn Antibodies for RND3
	ThermoFisher Antibodies for RND3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RND3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RND3

Protein Domains /
Families
for RND3 gene

ProtoNet protein and cluster: P61587

Function
for RND3 gene

miRNA Products:		OriGene 3'-UTR Clone: RND3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RND3
		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate RND3 (see all 36):
		hsa-miR-3678-3p hsa-miR-4307 hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-miR-429 hsa-miR-106a hsa-miR-128
		SwitchGear 3'UTR luciferase reporter plasmid: RND3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RND3 (see all 7) OriGene shRNA RFP: RND3 OriGene siRNA: RND3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RND3

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RND3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RND3 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RND3 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RND3 (NM_005168)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RND3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RND3
		Search LifeMap BioReagents cell lines for RND3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Rnd3)

Pathways & Interactions
for RND3 gene

	Super-pathway	contained gene-specific pathways
1	Cytoskeletal Signaling	Cytoskeletal Signaling 1.00
2	Selected targets of CREB1	Selected targets of CREB1 1.00
3	Selected targets of p53	Selected targets of p53 1.00

2 EMD Millipore Pathways for RND3

	Selected targets of CREB1
	Selected targets of p53

1 Cell Signaling Technology (CST) Pathway for RND3

Cytoskeletal Signaling

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for RND3 gene

Transcripts
for RND3 gene

Expression
for RND3 gene

RND3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTGTCTA

Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	CyT49 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Line H9 (WA09) (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RND3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RND3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RND3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RND3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND3

Orthologs
for RND3 gene

Paralogs
for RND3 gene

Paralogs for RND3 gene

RHOB²  RND1²  RHOD²  RHOA²  RHOF²  RHOC²  

18/26 SIMAP similar genes for RND3 using alignment to 4 protein entries:     RND3_HUMAN (see all proteins) (see all similar genes):

ARHE    RND2    RHOA    RND1    RHOC    RHOB

ARHA    RHOD    ARHG    RHOG    RHOF    RHOQ

RHOJ    RAC3    CDC42    RHOU    RAC2    RAC1

RND3 for paralogs           About GeneDecksing

Genomic Variants
for RND3 gene

10/333 NCBI SNPs in RND3 are shown (see all 333)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs752301891,2	F,	--	151324238(+)	TCCACG/AAATTG	2	--	ds5001		1		EA	120
rs64327741,2	C,F,A,H,	--	151324400(+)	TGCATC/TATATT	2	--	ds5001		35		NA NS EA WA CSA	3338
rs1888977531,2		--	151324637(+)	AGATTA/CTGTAA	2	--	ds5001		0	--	--	--	--
rs1929124511,2		--	151324641(+)	TCTGTA/TATCAC	2	--	ds5001		0	--	--	--	--
rs13724381,2	C,F,A,H,	--	151324688(+)	AAGTAG/TATAAT	2	--	ds5001		25		NA NS EA CSA WA	2668
rs113972591,2	C,	--	151324741(+)	TGAAGA/-AAAAA	2	--	ut31 trp3		1		CSA	2
rs58352991,2	C	--	151324744(+)	AAAAAA/-GTATG	2	--	ut31 trp3		1		NA	2
rs1474392771,2		--	151324848(+)	TATAAC/TAGTTA	2	--	ut31		0	--	--	--	--
rs1842348021,2		--	151324896(+)	GCACTC/TGCCAG	2	--	ut31		0	--	--	--	--
rs758401071,2		--	151325025(+)	AAGTGC/TTTGTA	2	--	ut31		1		WA	118

HapMap Linkage Disequilibrium report for RND3 (151324709 - 151395525 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for RND3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RND3

DNA2.0 Custom Variant and Variant Library Synthesis for RND3

Disorders / Diseases
for RND3 gene

9 diseases for RND3

1 Novoseek disease relationship for RND3 gene    About this table

Publications
for RND3 gene

PubMed articles for RND3 gene, integrated from 9 sources (see all 59): (articles sorted by number of sources associating them with RND3)

Utopia: connect your pdf to the dynamic world of online information

1. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. (PubMed id 8649376)^{1, 2, 3, 9} Foster R.... Settleman J. (1996)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Crystal structure of Rnd3/RhoE: functional implications. (PubMed id 12163169)^{1, 2} Fiegen D.... Ahmadian M.R. (2002)
4. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PubMed id 11940653)^{1, 2} Katoh H.... Negishi M. (2002)
5. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PubMed id 9531558)^{1, 2} Nobes C.D.... Chardin P. (1998)
6. Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. (PubMed id 19244113)^{1, 9} Klein R.M. and Aplin A.E. (2009)
7. RhoE binds to ROCK I and inhibits downstream signaling. (PubMed id 12773565)^{1, 9} Riento K.... Ridley A.J. (2003)
8. RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line. (PubMed id 17182035)^{1, 9} Poch E....Guasch R.M. (2007)
9. RhoE inhibits 4E-BP1 phosphorylation and eIF4E functi on impairing cap-dependent translation. (PubMed id 19850923)^{1, 9} Villalonga P....Ridley A.J. (2009)
10. RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. (PubMed id 17174923)^{1, 9} Ongusaha P.P....Lee S.W. (2006)

External Searches for RND3 gene

Genome Databases showing RND3 gene

Other Databases showing RND3 gene

Specialized Databases showing RND3 gene

Products
for RND3 gene