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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RND2 Gene

protein-coding   GIFtS: 48
GCID: GC17P041177

Rho Family GTPase 2

(Previous names: ras homolog gene family, member N)
(Previous symbol: ARHN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho Family GTPase 21 2 3     RhoN2
ARHN1 2 3 5     GTP-Binding Protein Rho72
RHO72 3 5     Rho-Related GTP-Binding Protein RhoN2
Ras Homolog Gene Family, Member N1 2     Rnd23
Rho-Related GTP-Binding Protein Rho72 3     

External Ids:    HGNC: 183151   Entrez Gene: 81532   Ensembl: ENSG000001088307   OMIM: 6015555   UniProtKB: P521983   

Export aliases for RND2 gene to outside databases

Previous GC identifers: GC17P038431 GC17P036943


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RND2 Gene:
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin
cytoskeleton organization in response to extracellular growth factors. This particular family member has been
implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome
17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RND2 Gene: 
RND2 (Rho family GTPase 2) is a protein-coding gene. Diseases associated with RND2 include bilateral breast cancer, and ovarian cancer. GO annotations related to this gene include GTP binding and protein N-terminus binding. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
Function: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the
Rho subfamily (By similarity)

Gene Wiki entry for RND2 (Rnd2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RND2 gene promoter:
         SRF   RP58   AP-1   SRF (504 AA)   Lmo2   N-Myc   MZF-1   IRF-7A   ITF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRND2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RND2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RND2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

RND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RND2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041177:  view genomic region     (about GC identifiers)

Start:
41,177,258 bp from pter      End:
41,184,058 bp from pter
Size:
6,801 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RND2_HUMAN, P52198 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoN precursor  
Size: 227 amino acids; 25369 Da
Subunit: Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side
(Potential). Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome
Secondary accessions: A8K2D4 O00690 O00734 Q5U0P6 Q99535

Explore the universe of human proteins at neXtProt for RND2: NX_P52198

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52198

  • RND2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_005431.1  
    ENSEMBL proteins: 
     ENSP00000466680   ENSP00000439328  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for RND2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002080acrosomal membrane IEA--
    GO:0005622intracellular ----
    GO:0005769early endosome IEA--
    GO:0016020membrane ----

    RND2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR003578 Small_GTPase_Rho

    Graphical View of Domain Structure for InterPro Entry P52198

    ProtoNet protein and cluster: P52198

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
    Similarity: Belongs to the small GTPase superfamily. Rho family


    RND2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RND2_HUMAN, P52198
    Function: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the
    Rho subfamily (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8938427
    GO:0005515protein binding IPI12590651
    GO:0005525GTP binding IEA--
    GO:0047485protein N-terminus binding IEA--
         
    RND2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RND2:
     Increased cilium length after   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RND2 
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    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate RND2 (see all 51):
    hsa-miR-194* hsa-miR-3685 hsa-miR-4307 hsa-miR-3938 hsa-miR-218-1* hsa-miR-1260b hsa-miR-301a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidRND2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RND2

    5/8 Interacting proteins for RND2 (P521981, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEOX2P502222, 3MINT-67514 I2D: score=4 
    RACGAP1Q9H0H53I2D: score=2 
    UBXN11Q5T1243I2D: score=2 
    ARHGAP5Q130173I2D: score=1 
    FNBP1Q96RU33I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8938427
    GO:0007165signal transduction TAS8938427
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0015031protein transport ----

    RND2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RND2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RND2

    1 Novoseek inferred chemical compound relationship for RND2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 71.7 2 16042565 (1)

    Search CenterWatch for drugs/clinical trials and news about RND2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RND2 gene: 
    NM_005440.4  

    Unigene Cluster for RND2:

    Rho family GTPase 2
    Hs.603111  [show with all ESTs]
    Unigene Representative Sequence: NM_005440
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587117 ENST00000587250 ENST00000544533
    miRNA
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    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate RND2 (see all 51):
    hsa-miR-194* hsa-miR-3685 hsa-miR-4307 hsa-miR-3938 hsa-miR-218-1* hsa-miR-1260b hsa-miR-301a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidRND2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209778.1 AF498968.1 AK096367.1 AK290199.1 BC094842.1 BC104986.1 BC104990.1 BT019394.1 
    X95456.1 

    4 DOTS entries:

    DT.309830  DT.120930880  DT.95161712  DT.95333056 

    24/85 AceView cDNA sequences (see all 85):

    BF510382 CA502963 AW292081 AI017832 H48939 AI377326 AI554560 BX105872 
    AI918221 AA443934 AF498968 X95456 CA393122 AI498599 BX096461 AI498035 
    BU850303 AI198282 AI368523 BI869361 NM_005440 AA444113 AI364325 BF346346 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RND2 expression in normal human tissues (normalized intensities)      RND2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGCTCAGG
    RND2 Expression
    About this image


    RND2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Thalamus
             Septum   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 5 entries
             ESI-017   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Heart (Cardiovascular System)
             Cardiac Crescent Cells Cardiac Crescent
     
     Liver (Hepatobiliary System)
             Periportal Hepatocytes Liver Lobule

    Genevestigator expression for RND2

    SOURCE GeneReport for Unigene cluster: Hs.603111

    UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
    Tissue specificity: Highly expressed in testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RND2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnd21 , 5 Rho family GTPase 21, 5 92.22(n)1
    98.68(a)1
      11 (65.12 cM)5
    118581  NM_009708.11  NP_033838.11 
     1014649995 
    chicken
    (Gallus gallus)
    Aves RND21 Rho family GTPase 2 75.62(n)
    77.97(a)
      428307  NM_001252123.1  NP_001239052.1 
    lizard
    (Anolis carolinensis)
    Reptilia RND26
    Rho family GTPase 2
    81(a)
    1 ↔ 1
    6(62653206-62707544)
    zebrafish
    (Danio rerio)
    Actinopterygii rnd21 Rho family GTPase 2 70.19(n)
    70.93(a)
      751645  NM_001045364.1  NP_001038829.1 


    ENSEMBL Gene Tree for RND2 (if available)
    TreeFam Gene Tree for RND2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RND2 gene
    RHOB2  RHOD2  RHOA2  RND12  RHOF2  ENSG000002718102  RHOC2  RND32  
    18/36 SIMAP similar genes for RND2 using alignment to 2 protein entries:     RND2_HUMAN (see all proteins) (see all similar genes):
    ARHE    RND3    RHOB    RHOD    RHOC    RND1
    RHOA    RHOF    RAC3    RAC2    ARHG    RAC1
    RHOG    RHOH    RHOJ    ARHA    RHOU    CDC42

    RND2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 SNPs in RND2 are shown (see all 164)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1117984841,2
    C,F--41176469(+) CACCGC/TGCCCG 1 -- us2k13Minor allele frequency- T:0.50NA WA 6
    rs1136774891,2
    C,F--41176473(+) GCGCCC/TGGCCT 1 -- us2k13Minor allele frequency- T:0.50NA WA 6
    rs1839826621,2
    --41176584(+) CAAGCA/CTCCAC 1 -- us2k10--------
    rs1891035481,2
    --41176587(+) GCATCC/TACCAG 1 -- us2k10--------
    rs803456491,2
    C,F--41176647(+) TCAGTC/GCACGC 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs1482944561,2
    --41176681(+) GTTAAC/GTCAAT 1 -- us2k10--------
    rs22988621,2
    C,F,H--41176688(-) CGGTTA/GCATTG 1 -- us2k125Minor allele frequency- G:0.32EA NS NA CSA WA 4197
    rs1920381281,2
    --41176791(+) AGACCC/TCCTGC 1 -- us2k10--------
    rs1152184781,2
    C,F--41176813(+) CGGACG/ACGGGA 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs22988611,2
    C,F,H--41176831(-) AGCCTC/TTTTGG 1 -- us2k125Minor allele frequency- T:0.33EA NS NA WA CSA 4181

    HapMap Linkage Disequilibrium report for RND2 (41177258 - 41184058 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RND2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672913CNV Deletion23128226
    esv33998OTHER Inversion15654335

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601555    OMIM disorders: --

    6 diseases for RND2:    About MalaCards
    bilateral breast cancer    ovarian cancer    wiskott-aldrich syndrome    breast cancer
    neuronitis    hepatitis


    RND2 for disorders           About GeneDecksing


    Export disorders for RND2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RND2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RND2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. (PubMed id 12590651)1, 2 Naud N.... Gacon G. (2003)
    4. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PubMed id 11940653)1, 2 Katoh H.... Negishi M. (2002)
    5. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PubMed id 9531558)1, 2 Nobes C.D.... Chardin P. (1998)
    6. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)1, 2 Smith T.M.... King M.-C. (1996)
    7. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. (PubMed id 14732713)1, 9 Kakimoto T....Negishi M. (2004)
    8. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. (PubMed id 12842009)1, 9 Wennerberg K....Hansen S.H. (2003)
    9. The GTPase-deficient Rnd proteins are stabilized by th eir effectors. (PubMed id 22807448)1 Goh L.L. and Manser E. (2012)
    10. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PubMed id 21989022)1 Garcia-Casado Z....Lopez-Guerrero J.A. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8153 HGNC: 18315 AceView: ARHN Ensembl:ENSG00000108830 euGenes: HUgn8153
    ECgene: RND2 H-InvDB: RND2

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for RND2 Pharmacogenomics, SNPs, Pathways

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