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Aliases for RND2 Gene

Aliases for RND2 Gene

  • Rho Family GTPase 2 2 3 4 5
  • Rho-Related GTP-Binding Protein Rho7 3 4
  • Ras Homolog Gene Family, Member N 2 3
  • ARHN 3 4
  • RHO7 3 4
  • Rho-Related GTP-Binding Protein RhoN 3
  • GTP-Binding Protein Rho7 3
  • CTD-3199J23.4 3
  • RhoN 3
  • Rnd2 4

External Ids for RND2 Gene

Previous HGNC Symbols for RND2 Gene

  • ARHN

Previous GeneCards Identifiers for RND2 Gene

  • GC17P038431
  • GC17P041177
  • GC17P036943
  • GC17P043027
  • GC17P043028
  • GC17P043098
  • GC17P043183
  • GC17P043199

Summaries for RND2 Gene

Entrez Gene Summary for RND2 Gene

  • This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]

GeneCards Summary for RND2 Gene

RND2 (Rho Family GTPase 2) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. GO annotations related to this gene include GTP binding and protein N-terminus binding. An important paralog of this gene is RND3.

UniProtKB/Swiss-Prot for RND2 Gene

  • May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).

Gene Wiki entry for RND2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RND2 Gene

Genomics for RND2 Gene

Regulatory Elements for RND2 Gene

Enhancers for RND2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G043314 1.6 Ensembl ENCODE dbSUPER 11.2 +290.7 290672 2.6 HNRNPUL1 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF143 NBR2 AOC3 NBR1 RND2 VAT1 AOC4P PTGES3L PSMC3IP LINC00854 GC17P043358
GH17G043322 1.7 Ensembl ENCODE dbSUPER 10 +297.9 297922 1.6 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ENSG00000267340 ENSG00000267002 ASB16-AS1 HMGN1P29 DHX8 NBR2 ENSG00000267765 HSD17B1 CCR10 LINC00910
GH17G043174 1.4 Ensembl ENCODE dbSUPER 11 +151.3 151310 3.5 FOXA2 ATF1 ARID4B ZNF48 YY1 REST PPARG KAT8 SSRP1 MIER3 NBR2 VAT1 RND2 PTGES3L ENSG00000267002 TMEM106A
GH17G042672 1.5 ENCODE dbSUPER 10 -346.5 -346544 11.4 MLX CREB3L1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 CNTNAP1 TUBG2 ENSG00000267002 ENSG00000259623 HMGN2P15 MLX ENSG00000267765 ENSG00000267340 HSD17B1P1 MEOX1
GH17G042561 1.4 ENCODE dbSUPER 10 -461.8 -461834 4.0 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SP3 NFYC TBX21 MEF2D TUBG2 MLX CNTNAP1 ENSG00000259623 ZNF385C KLHL10 ENSG00000267765 ENSG00000267340 RND2 COASY
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RND2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RND2 Gene

Chromosome:
17
Start:
43,025,241 bp from pter
End:
43,032,041 bp from pter
Size:
6,801 bases
Orientation:
Plus strand

Genomic View for RND2 Gene

Genes around RND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RND2 Gene

Proteins for RND2 Gene

  • Protein details for RND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52198-RND2_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoN
    Protein Accession:
    P52198
    Secondary Accessions:
    • A8K2D4
    • O00690
    • O00734
    • Q5U0P6
    • Q99535

    Protein attributes for RND2 Gene

    Size:
    227 amino acids
    Molecular mass:
    25369 Da
    Quaternary structure:
    • Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5.

neXtProt entry for RND2 Gene

Post-translational modifications for RND2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RND2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RND2 Gene

Domains & Families for RND2 Gene

Gene Families for RND2 Gene

Suggested Antigen Peptide Sequences for RND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52198

UniProtKB/Swiss-Prot:

RND2_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RND2: view

Function for RND2 Gene

Molecular function for RND2 Gene

UniProtKB/Swiss-Prot Function:
May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).

Gene Ontology (GO) - Molecular Function for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS,IEA --
GO:0005515 protein binding IPI 12590651
GO:0005525 GTP binding IEA --
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with RND2: view
genes like me logo Genes that share phenotypes with RND2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RND2
  • Applied Biological Materials Clones for RND2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RND2 Gene

Localization for RND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND2 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. {ECO:0000269 PubMed:12590651}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RND2 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
endosome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005769 early endosome IEA --
GO:0016020 membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with RND2: view

Pathways & Interactions for RND2 Gene

genes like me logo Genes that share pathways with RND2: view

Gene Ontology (GO) - Biological Process for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 8938427
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0048672 positive regulation of collateral sprouting IEA --
genes like me logo Genes that share ontologies with RND2: view

No data available for SIGNOR curated interactions for RND2 Gene

Drugs & Compounds for RND2 Gene

(1) Additional Compounds for RND2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RND2: view

Transcripts for RND2 Gene

Unigene Clusters for RND2 Gene

Rho family GTPase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RND2
  • Applied Biological Materials Clones for RND2

Alternative Splicing Database (ASD) splice patterns (SP) for RND2 Gene

No ASD Table

Relevant External Links for RND2 Gene

GeneLoc Exon Structure for
RND2
ECgene alternative splicing isoforms for
RND2

Expression for RND2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RND2 Gene

mRNA differential expression in normal tissues according to GTEx for RND2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.4), Brain - Hypothalamus (x5.8), Brain - Substantia nigra (x5.8), Testis (x5.7), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for RND2 Gene

This gene is overexpressed in Spinal cord (40.4) and Testis (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RND2 Gene



Protein tissue co-expression partners for RND2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RND2 Gene:

RND2

SOURCE GeneReport for Unigene cluster for RND2 Gene:

Hs.603111

mRNA Expression by UniProt/SwissProt for RND2 Gene:

P52198-RND2_HUMAN
Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for RND2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RND2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RND2 Gene

Orthologs for RND2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RND2 35 34
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RND2 35 34
  • 95.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RND2 35 34
  • 94.42 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnd2 34
  • 92.36 (n)
mouse
(Mus musculus)
Mammalia Rnd2 35 16 34
  • 92.22 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RND2 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves RND2 35 34
  • 75.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RND2 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rnd2 35 34
  • 69.9 (n)
OneToOne
Species where no ortholog for RND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RND2 Gene

ENSEMBL:
Gene Tree for RND2 (if available)
TreeFam:
Gene Tree for RND2 (if available)

Paralogs for RND2 Gene

genes like me logo Genes that share paralogs with RND2: view

Variants for RND2 Gene

Sequence variations from dbSNP and Humsavar for RND2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000135325 -- 43,031,175(+) ATGCC(A/T)GGTTC utr-variant-3-prime
rs1000165862 -- 43,027,009(+) TTCTG(C/T)CCGCT intron-variant
rs1000213974 -- 43,032,371(+) CTGAA(G/T)TAGCT downstream-variant-500B
rs1000709241 -- 43,026,576(+) CCTGG(A/G)AGGCG intron-variant
rs1001004139 -- 43,025,189(+) GGGGG(C/G)GGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RND2 Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159

Variation tolerance for RND2 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RND2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RND2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RND2 Gene

Disorders for RND2 Gene

Relevant External Links for RND2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RND2

No disorders were found for RND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RND2 Gene

Publications for RND2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. (PMID: 14732713) Kakimoto T. … Negishi M. (J. Biol. Chem. 2004) 3 22 64
  4. Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. (PMID: 12590651) Naud N. … Gacon G. (Biochem. J. 2003) 3 4 64
  5. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. (PMID: 12842009) Wennerberg K. … Hansen S.H. (Curr. Biol. 2003) 3 22 64

Products for RND2 Gene

Sources for RND2 Gene

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