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RND2 Gene

protein-coding   GIFtS: 48
GCID: GC17P041177

Rho Family GTPase 2

(Previous names: ras homolog gene family, member N)
(Previous symbol: ARHN)
  See RND2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Family GTPase 21 2 3     CTD-3199J23.42
ARHN1 2 3 5     RhoN2
RHO72 3 5     GTP-Binding Protein Rho72
Ras Homolog Gene Family, Member N1 2     Rho-Related GTP-Binding Protein RhoN2
Rho-Related GTP-Binding Protein Rho72 3     Rnd23

External Ids:    HGNC: 183151   Entrez Gene: 81532   Ensembl: ENSG000001088307   OMIM: 6015555   UniProtKB: P521983   

Export aliases for RND2 gene to outside databases

Previous GC identifers: GC17P038431 GC17P036943


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RND2 Gene:
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin
cytoskeleton organization in response to extracellular growth factors. This particular family member has been
implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome
17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. (provided by RefSeq,
Jul 2008)

GeneCards Summary for RND2 Gene:
RND2 (Rho family GTPase 2) is a protein-coding gene. Diseases associated with RND2 include ovarian cancer. GO annotations related to this gene include GTP binding and protein N-terminus binding. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
Function: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the
Rho subfamily (By similarity)

Gene Wiki entry for RND2 (Rnd2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RND2 gene promoter:
         SRF   RP58   AP-1   SRF (504 AA)   Lmo2   N-Myc   MZF-1   IRF-7A   ITF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRND2 promoter sequence
   Search Chromatin IP Primers for RND2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RND2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

RND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RND2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041177:  view genomic region     (about GC identifiers)

Start:
41,177,258 bp from pter      End:
41,184,058 bp from pter
Size:
6,801 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RND2_HUMAN, P52198 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoN precursor  
Size: 227 amino acids; 25369 Da
Subunit: Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5
Secondary accessions: A8K2D4 O00690 O00734 Q5U0P6 Q99535

Explore the universe of human proteins at neXtProt for RND2: NX_P52198

Explore proteomics data for RND2 at MOPED


See RND2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005431.1  
ENSEMBL proteins: 
 ENSP00000466680   ENSP00000439328  

RND2 Human Recombinant Protein Products:

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Novus Biologicals RND2 Protein
Novus Biologicals RND2 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for RND2

 
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antibodies-online proteins for RND2 (5 products) 

 
antibodies-online peptides for RND2

RND2 Antibody Products:

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Abcam antibodies for RND2
Cloud-Clone Corp. Antibodies for RND2
Search ThermoFisher Antibodies for RND2
antibodies-online antibodies for RND2 (21 products) 

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Cloud-Clone Corp. ELISAs for RND2
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antibodies-online kits for RND2 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR027417 P-loop_NTPase
 IPR003578 Small_GTPase_Rho

Graphical View of Domain Structure for InterPro Entry P52198

ProtoNet protein and cluster: P52198

2 Blocks protein domains:
IPB001806 Transforming protein P21 RAS signature
IPB003578 Ras small GTPase


UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
Similarity: Belongs to the small GTPase superfamily. Rho family


Find genes that share domains with RND2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RND2_HUMAN, P52198
Function: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the
Rho subfamily (By similarity)

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity TAS8938427
GO:0005515protein binding IPI12590651
GO:0005525GTP binding IEA--
GO:0047485protein N-terminus binding IEA--
     
Find genes that share ontologies with RND2           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for RND2:
 Increased cilium length after   Increased gamma-H2AX phosphory 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for RND2

miRNA
Products:
    
miRTarBase miRNAs that target RND2:
hsa-mir-15b-3p (MIRT038658), hsa-mir-26a-5p (MIRT050163)

Block miRNA regulation of human, mouse, rat RND2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RND2 (see all 51):
hsa-miR-194* hsa-miR-3685 hsa-miR-4307 hsa-miR-3938 hsa-miR-218-1* hsa-miR-1260b hsa-miR-301a hsa-miR-570
SwitchGear 3'UTR luciferase reporter plasmidRND2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RND2
Predesigned siRNA for gene silencing in human, mouse, rat RND2

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RND2

Clone
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OriGene clones in human, mouse for RND2 (see all 6)
OriGene ORF clones in mouse, rat for RND2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RND2 (NM_005440)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RND2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND2
Addgene plasmids for RND2 

Cell Line
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GenScript Custom overexpressing Cell Line Services for RND2
Browse ESI BIO Cell Lines and PureStem Progenitors for RND2 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RND2_HUMAN, P52198: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side
(Potential). Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
cytoskeleton2
endosome2
nucleus2
extracellular1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002080acrosomal membrane IEA--
GO:0005622intracellular ----
GO:0005769early endosome IEA--
GO:0016020membrane ----

Find genes that share ontologies with RND2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RND2 (see all 33)
    Fc-GammaR Pathway
Molecular Mechanisms of Cancer
Antioxidant Action of Vitamin-C
Tec Kinases Signaling
Crosstalk Between CARM1 and ESRs


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RND2
Interactions:

    Search GeneGlobe Interaction Network for RND2

Selected Interacting proteins for RND2 (P521981, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
MEOX2P502222, 3MINT-67514 I2D: score=4 
RACGAP1Q9H0H53I2D: score=2 
UBXN11Q5T1243I2D: score=2 
ARHGAP5Q130173I2D: score=1 
FNBP1Q96RU33I2D: score=1 
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process TAS8938427
GO:0007165signal transduction TAS8938427
GO:0007264small GTPase mediated signal transduction IEA--
GO:0015031protein transport ----
GO:0048672positive regulation of collateral sprouting IEA--

Find genes that share ontologies with RND2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RND2

1 Novoseek inferred chemical compound relationship for RND2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gtp 71.7 2 16042565 (1)



Find genes that share compounds with RND2           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RND2 gene: 
NM_005440.4  

Unigene Cluster for RND2:

Rho family GTPase 2
Hs.603111  [show with all ESTs]
Unigene Representative Sequence: NM_005440
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000587117 ENST00000587250 ENST00000544533
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RND2 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate RND2 (see all 51):
hsa-miR-194* hsa-miR-3685 hsa-miR-4307 hsa-miR-3938 hsa-miR-218-1* hsa-miR-1260b hsa-miR-301a hsa-miR-570
SwitchGear 3'UTR luciferase reporter plasmidRND2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RND2
Predesigned siRNA for gene silencing in human, mouse, rat RND2
Clone
Products:
     
OriGene clones in human, mouse for RND2 (see all 6)
OriGene ORF clones in mouse, rat for RND2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RND2 (NM_005440)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RND2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND2
Addgene plasmids for RND2 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for RND2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RND2
  QuantiTect SYBR Green Assays in human, mouse, rat RND2
  QuantiFast Probe-based Assays in human, mouse, rat RND2

Additional mRNA sequence: 

AB209778.1 AF498968.1 AK096367.1 AK290199.1 BC094842.1 BC104986.1 BC104990.1 BT019394.1 
X95456.1 

4 DOTS entries:

DT.309830  DT.120930880  DT.95161712  DT.95333056 

Selected AceView cDNA sequences (see all 85):

AI377326 AW292081 AI918221 AI498599 AA443934 AI017832 AI498035 H48939 
X95456 AF498968 BU850303 AI554560 BF346346 CA393122 CA502963 BX096461 
BF510382 AA444113 AI364325 AI198282 BI869361 NM_005440 BX105872 AI368523 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RND2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAGCTCAGG
RND2 Expression
About this image


RND2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Brain (Nervous System)    fully expand to see all 20 entries
         Thalamus
         Septum   
 
 Heart (Cardiovascular System)    fully expand to see all 2 entries
         Cardiac Crescent Cells Cardiac Crescent
 
 NULL (Uncategorized)
         Mesenchymal Progenitor Cells - Passage 2
 
 Liver (Hepatobiliary System)
         Periportal Hepatocytes Liver Lobule
RND2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RND2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.603111

UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
Tissue specificity: Highly expressed in testis

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RND2 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnd21 , 5 Rho family GTPase 21, 5 92.22(n)1
98.68(a)1
  11 (65.12 cM)5
118581  NM_009708.11  NP_033838.11 
 1014649995 
chicken
(Gallus gallus)
Aves RND21 Rho family GTPase 2 75.62(n)
77.97(a)
  428307  NM_001252123.1  NP_001239052.1 
lizard
(Anolis carolinensis)
Reptilia RND26
Rho family GTPase 2
81(a)
1 ↔ 1
6(62653206-62707544)
zebrafish
(Danio rerio)
Actinopterygii rnd21 Rho family GTPase 2 69.9(n)
70.93(a)
  751645  NM_001045364.1  NP_001038829.1 


ENSEMBL Gene Tree for RND2 (if available)
TreeFam Gene Tree for RND2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RND2 gene
RHOB2  RND12  RHOA2  RHOD2  RHOF2  ENSG000002718102  RHOC2  RND32  
Selected SIMAP similar genes for RND2 using alignment to 2 protein entries:     RND2_HUMAN (see all proteins) (see all similar genes):
ARHE    RND3    RHOB    RHOD    RHOC    RND1
RHOA    RHOF    RAC3    RAC2    ARHG    RAC1
RHOG    RHOH    RHOJ    ARHA    RHOU    CDC42

Find genes that share paralogs with RND2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RND2 (see all 164)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1117984841,2
C,F--41176469(+) CACCGC/TGCCCG 1 -- us2k13Minor allele frequency- T:0.50NA WA 6
rs1136774891,2
C,F--41176473(+) GCGCCC/TGGCCT 1 -- us2k13Minor allele frequency- T:0.50NA WA 6
rs1839826621,2
--41176584(+) CAAGCA/CTCCAC 1 -- us2k10--------
rs1891035481,2
--41176587(+) GCATCC/TACCAG 1 -- us2k10--------
rs803456491,2
C,F--41176647(+) TCAGTC/GCACGC 1 -- us2k12Minor allele frequency- G:0.10WA 120
rs1482944561,2
--41176681(+) GTTAAC/GTCAAT 1 -- us2k10--------
rs22988621,2
C,F,H--41176688(-) CGGTTA/GCATTG 1 -- us2k125Minor allele frequency- G:0.32EA NS NA CSA WA 4197
rs1920381281,2
--41176791(+) AGACCC/TCCTGC 1 -- us2k10--------
rs1152184781,2
C,F--41176813(+) CGGACG/ACGGGA 1 -- us2k11Minor allele frequency- A:0.06WA 118
rs22988611,2
C,F,H--41176831(-) AGCCTC/TTTTGG 1 -- us2k125Minor allele frequency- T:0.33EA NS NA WA CSA 4181

HapMap Linkage Disequilibrium report for RND2 (41177258 - 41184058 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for RND2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2672913CNV Deletion23128226
esv33998OTHER Inversion15654335

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RND2
DNA2.0 Custom Variant and Variant Library Synthesis for RND2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601555    OMIM disorders: --

1 disease for RND2:    
About MalaCards
ovarian cancer


Find genes that share disorders with RND2           About GenesLikeMe


Export disorders for RND2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RND2 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with RND2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. (PubMed id 12590651)1, 2 Naud N.... Gacon G. (Biochem. J. 2003)
  4. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PubMed id 11940653)1, 2 Katoh H.... Negishi M. (Mol. Cell. Biol. 2002)
  5. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PubMed id 9531558)1, 2 Nobes C.D.... Chardin P. (J. Cell Biol. 1998)
  6. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)1, 2 Smith T.M.... King M.-C. (Genome Res. 1996)
  7. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. (PubMed id 14732713)1, 9 Kakimoto T....Negishi M. (J. Biol. Chem. 2004)
  8. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. (PubMed id 12842009)1, 9 Wennerberg K....Hansen S.H. (Curr. Biol. 2003)
  9. The GTPase-deficient Rnd proteins are stabilized by their effectors. (PubMed id 22807448)1 Goh L.L. and Manser E. (J. Biol. Chem. 2012)
  10. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PubMed id 21989022)1 Garcia-Casado Z....Lopez-Guerrero J.A. (BMC Med. Genet. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8153 HGNC: 18315 AceView: ARHN Ensembl:ENSG00000108830 euGenes: HUgn8153
ECgene: RND2 H-InvDB: RND2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RND2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RND2 gene:
Search GeneIP for patents involving RND2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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