Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RND2 Gene

protein-coding   GIFtS: 47
GCID: GC17P041177

Rho family GTPase 2

(Previous names: ras homolog gene family, member N )
(Previous symbol: ARHN)
 Explore 7 diseases affiliated with
RND2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RND2    

Aliases
for RND2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Rho Family GTPase 21 2 3     Rho-Related GTP-Binding Protein Rho72 3
ARHN1 2 3 5     Rho71
RHO72 3 5     GTP-Binding Protein Rho72
RhoN1 2     Rho-Related GTP-Binding Protein RhoN2
Ras Homolog Gene Family, Member N1 2     Rnd23

External Ids:    HGNC: 183151   Entrez Gene: 81532   Ensembl: ENSG000002672677   OMIM: 6015555   UniProtKB: P521983   

Export aliases for RND2 gene to outside databases

Previous GC identifers: GC17P038431 GC17P036943


Summaries
for RND2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RND2:
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin
cytoskeleton organization in response to extracellular growth factors. This particular family member has been
implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and
is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
Function: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho
subfamily (By similarity)

Gene Wiki entry for RND2 (Rnd2)


Genomic Views
for RND2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RND2 gene promoter:
         SRF   RP58   AP-1   SRF (504 AA)   Lmo2   N-Myc   MZF-1   IRF-7A   ITF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RND2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RND2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RND2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

RND2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RND2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041177:  view genomic region     (about GC identifiers)

Start:
 41,177,258 bp from pter      End:
 41,184,058 bp from pter
Size:
 6,801 bases      Orientation:
 plus strand

Proteins
for RND2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RND2_HUMAN, P52198 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein RhoN precursor  
Size: 227 amino acids; 25369 Da
Subunit: Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5
Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side
(Potential). Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome
Secondary accessions: A8K2D4 O00690 O00734 Q5U0P6 Q99535

Explore the universe of human proteins at neXtProt for RND2: NX_P52198

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52198

    • RND2 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins: NP_005431.1  
    Human Recombinant Protein Products for RND2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: RND2
    OriGene Protein Over-expression Lysate: RND2
    OriGene Custom Protein Services for RND2 
    GenScript Custom Purified and Recombinant Proteins Services for RND2
    Novus Biologicals RND2 Protein
    Novus Biologicals RND2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RND2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002080acrosomal membrane IEA--
    GO:0005769early endosome IEA--

    RND2 for ontologies           About GeneDecksing



    RND2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RND2 
    GenScript Custom Superior Antibodies Services for RND2
    Novus Biologicals RND2 Antibodies
    Abcam antibodies for RND2 
    Uscn Antibodies for RND2
    Search ThermoFisher Antibodies for RND2

    Assay Products for RND2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RND2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for RND2

    Protein Domains /
    Families
    for RND2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RND2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR003578 Small_GTPase_Rho
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase

    Graphical View of Domain Structure for InterPro Entry P52198

    ProtoNet protein and cluster: P52198

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB003578 Ras small GTPase


    UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
    Similarity: Belongs to the small GTPase superfamily. Rho family


    Function
    for RND2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RND2_HUMAN, P52198
    Function: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho
    subfamily (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity TAS8938427
    GO:0005515protein binding IPI14732713
    GO:0005525GTP binding IEA--
    GO:0047485protein N-terminus binding IEA--
         
    RND2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RND2:
     Increased cilium length after   Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RND2 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: RND2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RND2
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate RND2 (see all 51):
    hsa-miR-194* hsa-miR-3685 hsa-miR-4307 hsa-miR-3938 hsa-miR-218-1* hsa-miR-1260b hsa-miR-301a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: RND2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RND2 (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RND2
    Sirion Biotech Custom design and validation of potent shRNA sequences against RND2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RND2
    Sirion Biotech Customized adenovirus for overexpression of RND2 
    Sirion Biotech Customized adenovirus for potent knockdown of RND2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RND2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RND2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RND2 (NM_005440)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RND2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RND2
    Search LifeMap BioReagents cell lines for RND2
    Sirion Biotech Customized stable knockdown cell line services for RND2 
    Sirion Biotech Customized inducible knockdown cell line services for RND2
    Sirion Biotech Customized stable overexpressing cell line services for RND2
    Sirion Biotech Customized inducible overexpressing cell line services for RND2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND2


    Pathways & Interactions
    for RND2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RND2

    5/8 Interacting proteins for RND2 (P521981, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEOX2P502222, 3MINT-67514 I2D: score=4 
    RACGAP1Q9H0H53I2D: score=2 
    UBXN11Q5T1243I2D: score=2 
    ARHGAP5Q130173I2D: score=1 
    FNBP1Q96RU33I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process TAS8938427
    GO:0007165signal transduction TAS8938427
    GO:0007264small GTPase mediated signal transduction IEA--

    RND2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RND2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RND2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RND2
    1 Novoseek chemical compound relationship for RND2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 71.7 2 16042565 (1)

    Search CenterWatch for drugs/clinical trials and news about RND2 

    Transcripts
    for RND2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RND2 gene: 
    NM_005440.4  

    Unigene Cluster for RND2:

    Rho family GTPase 2
    Hs.603111  [show with all ESTs]
    Unigene Representative Sequence: NM_005440
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000225973(lincRNA)(uc002icn.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RND2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RND2
    8/51 QIAGEN miScript miRNA Assays for microRNAs that regulate RND2 (see all 51):
    hsa-miR-194* hsa-miR-3685 hsa-miR-4307 hsa-miR-3938 hsa-miR-218-1* hsa-miR-1260b hsa-miR-301a hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: RND2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RND2 (see all 6)
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RND2
    Sirion Biotech Custom design and validation of potent shRNA sequences against RND2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RND2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RND2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RND2 (NM_005440)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RND2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RND2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RND2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RND2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RND2

    Additional cDNA sequence: 

    AB209778.1 AF498968.1 AK096367.1 AK290199.1 BC094842.1 BC104986.1 BC104990.1 BT019394.1 
    X95456.1 

    4 DOTS entries:

    DT.309830  DT.120930880  DT.95161712  DT.95333056 

    24/85 AceView cDNA sequences (see all 85):

    AF498968 BX096461 BX105872 AI364325 X95456 NM_005440 AI198282 AI368523 
    BI869361 BF510382 BU850303 CA502963 AA444113 H48939 CA393122 AI498035 
    AW292081 AI017832 BF346346 AI554560 AI498599 AI918221 AA443934 AI377326 

    GeneLoc Exon Structure


    Expression
    for RND2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RND2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGCTCAGG
    RND2 Expression
    About this image

    RND2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    BrainCerebral CortexBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

    Genevestigator expression for RND2

    SOURCE GeneReport for Unigene cluster: Hs.603111

    UniProtKB/Swiss-Prot: RND2_HUMAN, P52198
    Tissue specificity: Highly expressed in testis

        SABiosciences Custom PCR Arrays for RND2
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RND2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RND2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RND2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RND2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND2

    Orthologs
    for RND2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RND2 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnd21 , 5 Rho family GTPase 21, 5 92.22(n)1
    98.68(a)1    		   11 (65.12 cM)5
    118581  NM_009708.11  NP_033838.11 
     1014649995 
    chicken
    (Gallus gallus)    		 Aves RND21 Rho family GTPase 2 75.62(n)
    77.97(a)    		   428307  NM_001252123.1  NP_001239052.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rnd21 Rho family GTPase 2 70.19(n)
    70.93(a)    		   751645  NM_001045364.1  NP_001038829.1 


    ENSEMBL Gene Tree for RND2 (if available)
    TreeFam Gene Tree for RND2 (if available) 

    Paralogs
    for RND2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RND2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/166 NCBI SNPs in RND2 are shown (see all 166)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs750466401,2
    		C--41175757(+) TAACA-/TAGTGAT 2 -- us2k10--------
    rs21569121,2
    		H--41175853(-) AGCTGA/TGATCG 2 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1829004591,2
    		--41175893(+) CAATCC/TTCCCA 2 -- us2k10--------
    rs1874525541,2
    		--41175942(+) CACCAA/CGCCCG 2 -- us2k10--------
    rs1120730021,2
    		--41176043(+) TTTTTC/TCTAGA 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1929152271,2
    		--41176191(+) CATATA/GTTATT 2 -- us2k10--------
    rs781349661,2
    		F--41176249(+) TCTATC/TGCACA 2 -- us2k13Minor allele frequency- T:0.50NA 8
    rs761825361,2
    		C,F--41176260(+) AGCTGG/AAGTGC 2 -- us2k12Minor allele frequency- A:0.50NA 6
    rs1114854801,2
    		C--41176274(+) AGGCACG/-ATCTC 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs72245811,2
    		C,F,A,H--41176290(+) actgcC/Aagctc 2 -- us2k14Minor allele frequency- A:0.50NA 10

    HapMap Linkage Disequilibrium report for RND2 (41177258 - 41184058 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RND2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RND2
    DNA2.0 Custom Variant and Variant Library Synthesis for RND2

    Disorders / Diseases
    for RND2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RND2 for disorders           About GeneDecksing

    OMIM gene information: 601555    OMIM disorders: --

    7 diseases for RND2:    About MalaCards
    breast-ovarian cancer    wiskott-aldrich syndrome    ovarian cancer    bilateral breast cancer
    neuronitis    breast cancer    hepatitis


    Export disorders for RND2 gene to outside databases

    Publications
    for RND2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RND2 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RND2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. (PubMed id 12590651)1, 2 Naud N.... Gacon G. (2003)
    4. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PubMed id 11940653)1, 2 Katoh H.... Negishi M. (2002)
    5. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PubMed id 9531558)1, 2 Nobes C.D.... Chardin P. (1998)
    6. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)1, 2 Smith T.M.... King M.-C. (1996)
    7. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. (PubMed id 14732713)1, 9 Kakimoto T....Negishi M. (2004)
    8. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. (PubMed id 12842009)1, 9 Wennerberg K....Hansen S.H. (2003)
    9. The GTPase-deficient Rnd proteins are stabilized by th eir effectors. (PubMed id 22807448)1 Goh L.L. and Manser E. (2012)
    10. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PubMed id 21989022)1 Garcia-Casado Z....Lopez-Guerrero J.A. (2011)

    External Searches for RND2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RND2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8153 HGNC: 18315 AceView: ARHN Ensembl:ENSG00000267267 euGenes: HUgn8153
    ECgene: RND2 H-InvDB: RND2

    Other Databases showing RND2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RND2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RND2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RND2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RND2 gene:
    Search GeneIP for patents involving RND2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RND2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RND2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RND2  
     OriGene Protein Over-expression Lysate for RND2   Browse OriGene Fluorogenic Cell Assay Kits  
     Browse OriGene siRNAs   OriGene 3'-UTR Clone for RND2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RND2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RND2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for RND2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RND2   OriGene Custom Protein Services for RND2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RND2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RND2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RND2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RND2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RND2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RND2
     GenScript Custom Purified and Recombinant Proteins Services for RND2 GenScript cDNA clones with any tag delivered in your preferred vector for RND2
     GenScript Custom Assay Services for RND2 GenScript Custom Superior Antibodies Services for RND2
     GenScript Custom overexpressing Cell Line Services for RND2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in RND2 promoter
     Search Chromatin IP Primers for RND2
     RT2 qPCR Primer Assay in human, mouse, rat RND2
     Search GNC Networks for RND2
     SABiosciences Custom PCR Arrays for RND2
     Search Tocris compounds for RND2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RND2 antibodies
     RND2 proteins
     RND2 lysates
     Antibodies for RND2
     See all of Abcam's Antibodies, Kits and Proteins for RND2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     RND2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for RND2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND2
     SwitchGear 3'UTR luciferase reporter plasmids for RND2
     SwitchGear Promoter luciferase reporter plasmids for RND2
     Search ThermoFisher Antibodies for RND2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RND2
    Sirion Biotech Customized:
     stable knockdown cell line services for RND2
     inducible knockdown cell line services for RND2
     design and validation of potent shRNA sequences against RND2
     adenovirus for potent knockdown of RND2
     adenovirus for overexpression of RND2
     stable overexpressing cell line services for RND2
     inducible overexpressing cell line services for RND2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RND2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4