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Aliases for RND2 Gene

Aliases for RND2 Gene

  • Rho Family GTPase 2 2 3 4
  • ARHN 3 4 6
  • RHO7 3 4 6
  • Rho-Related GTP-Binding Protein Rho7 3 4
  • Ras Homolog Gene Family, Member N 2 3
  • Rho-Related GTP-Binding Protein RhoN 3
  • GTP-Binding Protein Rho7 3
  • CTD-3199J23.4 3
  • RhoN 3
  • Rnd2 4

External Ids for RND2 Gene

Previous Symbols for RND2 Gene

  • ARHN

Summaries for RND2 Gene

Entrez Gene Summary for RND2 Gene

  • This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]

GeneCards Summary for RND2 Gene

RND2 (Rho Family GTPase 2) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Akt Signaling. GO annotations related to this gene include GTP binding and protein N-terminus binding. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RND2 Gene

  • May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).

Gene Wiki entry for RND2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RND2 Gene

Genomics for RND2 Gene

Genomic Location for RND2 Gene

Start:
43,025,241 bp from pter
End:
43,032,041 bp from pter
Size:
6,801 bases
Orientation:
Plus strand

Genomic View for RND2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RND2 Gene

Regulatory Elements for RND2 Gene

Proteins for RND2 Gene

  • Protein details for RND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52198-RND2_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoN
    Protein Accession:
    P52198
    Secondary Accessions:
    • A8K2D4
    • O00690
    • O00734
    • Q5U0P6
    • Q99535

    Protein attributes for RND2 Gene

    Size:
    227 amino acids
    Molecular mass:
    25369 Da
    Quaternary structure:
    • Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5.

neXtProt entry for RND2 Gene

Proteomics data for RND2 Gene at MOPED

Post-translational modifications for RND2 Gene

No Post-translational modifications

Other Protein References for RND2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RND2 Gene

Domains for RND2 Gene

Suggested Antigen Peptide Sequences for RND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52198

UniProtKB/Swiss-Prot:

RND2_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Rho family.:
    • P52198
genes like me logo Genes that share domains with RND2: view

No data available for Gene Families for RND2 Gene

Function for RND2 Gene

Molecular function for RND2 Gene

UniProtKB/Swiss-Prot Function: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).

Gene Ontology (GO) - Molecular Function for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity TAS 8938427
GO:0005515 protein binding IPI 12590651
GO:0005525 GTP binding IEA --
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with RND2: view

Phenotypes for RND2 Gene

genes like me logo Genes that share phenotypes with RND2: view

miRNA for RND2 Gene

miRTarBase miRNAs that target RND2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RND2 Gene

Localization for RND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND2 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. {ECO:0000269 PubMed:12590651}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RND2 Gene COMPARTMENTS Subcellular localization image for RND2 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
endosome 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005622 intracellular --
GO:0005769 early endosome IEA --
GO:0016020 membrane --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with RND2: view

Pathways for RND2 Gene

genes like me logo Genes that share pathways with RND2: view

Pathways by source for RND2 Gene

Gene Ontology (GO) - Biological Process for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007165 signal transduction TAS 8938427
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008152 metabolic process TAS 8938427
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with RND2: view

Compounds for RND2 Gene

(1) Novoseek inferred chemical compound relationships for RND2 Gene

Compound -log(P) Hits PubMed IDs
gtp 71.7 1
genes like me logo Genes that share compounds with RND2: view

Transcripts for RND2 Gene

mRNA/cDNA for RND2 Gene

Unigene Clusters for RND2 Gene

Rho family GTPase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RND2 Gene

No ASD Table

Relevant External Links for RND2 Gene

GeneLoc Exon Structure for
RND2
ECgene alternative splicing isoforms for
RND2

Expression for RND2 Gene

mRNA expression in normal human tissues for RND2 Gene

mRNA differential expression in normal tissues according to GTEx for RND2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.4), Brain - Hypothalamus (5.8), Brain - Substantia nigra (5.8), Testis (5.7), and Brain - Nucleus accumbens (basal ganglia) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RND2 Gene

SOURCE GeneReport for Unigene cluster for RND2 Gene Hs.603111

mRNA Expression by UniProt/SwissProt for RND2 Gene

P52198-RND2_HUMAN
Tissue specificity: Highly expressed in testis
genes like me logo Genes that share expressions with RND2: view

Orthologs for RND2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RND2 35
  • 99.71 (n)
  • 100 (a)
RND2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RND2 35
  • 94.42 (n)
  • 98.68 (a)
RND2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RND2 35
  • 95.01 (n)
  • 98.24 (a)
RND2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnd2 35
  • 92.22 (n)
  • 98.68 (a)
Rnd2 16
Rnd2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RND2 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnd2 35
  • 92.36 (n)
  • 98.68 (a)
chicken
(Gallus gallus)
Aves RND2 35
  • 75.62 (n)
  • 77.97 (a)
RND2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RND2 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rnd2 35
  • 69.9 (n)
  • 70.93 (a)
rnd2 36
  • 68 (a)
OneToOne
Species with no ortholog for RND2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RND2 Gene

ENSEMBL:
Gene Tree for RND2 (if available)
TreeFam:
Gene Tree for RND2 (if available)

Paralogs for RND2 Gene

Paralogs for RND2 Gene

genes like me logo Genes that share paralogs with RND2: view

Variants for RND2 Gene

Sequence variations from dbSNP and Humsavar for RND2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs915945 -- 43,027,847(-) CTGGC(A/G)TGGGC intron-variant
rs915946 -- 43,027,836(-) CTGTG(C/G)ACTCT intron-variant
rs2298861 -- 43,024,814(-) AGCCT(C/T)TTTGG upstream-variant-2KB
rs2298862 -- 43,024,671(-) CGGTT(A/G)CATTG upstream-variant-2KB
rs7220013 -- 43,030,880(+) GATCA(C/G)AGTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RND2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
esv2672913 CNV Deletion 23128226

Relevant External Links for RND2 Gene

HapMap Linkage Disequilibrium report
RND2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RND2 Gene

Disorders for RND2 Gene

No disorders were found for RND2 Gene.

No data available for UniProtKB/Swiss-Prot for RND2 Gene

Publications for RND2 Gene

  1. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. (PMID: 12842009) Wennerberg K. … Hansen S.H. (Curr. Biol. 2003) 3 23
  2. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. (PMID: 14732713) Kakimoto T. … Negishi M. (J. Biol. Chem. 2004) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PMID: 8938427) Smith T.M. … King M.-C. (Genome Res. 1996) 3 4

Products for RND2 Gene

Sources for RND2 Gene

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