Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RND1 Gene

Aliases for RND1 Gene

  • Rho Family GTPase 1 2 3 4
  • RHO6 3 4 6
  • Rho-Related GTP-Binding Protein Rho6 3
  • Ras Homolog Gene Family, Member S 3
  • Ras Homolog Gene Family 2
  • Member S 2
  • ARHS 3
  • RHOS 3
  • Rnd1 4

External Ids for RND1 Gene

Previous GeneCards Identifiers for RND1 Gene

  • GC12M047537
  • GC12M049250
  • GC12M046283

Summaries for RND1 Gene

Entrez Gene Summary for RND1 Gene

  • This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]

GeneCards Summary for RND1 Gene

RND1 (Rho Family GTPase 1) is a Protein Coding gene. Diseases associated with RND1 include alcoholic psychosis and mood disorder. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOA.

UniProtKB/Swiss-Prot for RND1 Gene

  • Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.

Gene Wiki entry for RND1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RND1 Gene

Genomics for RND1 Gene

Regulatory Elements for RND1 Gene

Genomic Location for RND1 Gene

Start:
48,857,133 bp from pter
End:
48,865,898 bp from pter
Size:
8,766 bases
Orientation:
Minus strand

Genomic View for RND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RND1 Gene

Proteins for RND1 Gene

  • Protein details for RND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92730-RND1_HUMAN
    Recommended name:
    Rho-related GTP-binding protein Rho6
    Protein Accession:
    Q92730
    Secondary Accessions:
    • A8K9P7

    Protein attributes for RND1 Gene

    Size:
    232 amino acids
    Molecular mass:
    26056 Da
    Quaternary structure:
    • Binds GRB7 and PLXNB1. Interacts with UBXD5. Interacts with PLXNA2.

    Three dimensional structures from OCA and Proteopedia for RND1 Gene

neXtProt entry for RND1 Gene

Proteomics data for RND1 Gene at MOPED

Post-translational modifications for RND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RND1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RND1 Gene

Domains for RND1 Gene

Suggested Antigen Peptide Sequences for RND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92730

UniProtKB/Swiss-Prot:

RND1_HUMAN :
  • Q92730
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RND1: view

No data available for Gene Families for RND1 Gene

Function for RND1 Gene

Molecular function for RND1 Gene

UniProtKB/Swiss-Prot Function: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.

Gene Ontology (GO) - Molecular Function for RND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity NAS 11095956
GO:0005102 receptor binding IPI 19843518
GO:0005515 protein binding IPI 10664463
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RND1: view

Animal Model Products

CRISPR Products

miRNA for RND1 Gene

miRTarBase miRNAs that target RND1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RND1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RND1 Gene

Localization for RND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND1 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RND1 Gene COMPARTMENTS Subcellular localization image for RND1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
extracellular 2
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005912 adherens junction IDA 9531558
genes like me logo Genes that share ontologies with RND1: view

Pathways for RND1 Gene

genes like me logo Genes that share pathways with RND1: view

Pathways by source for RND1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for RND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007015 actin filament organization IDA 11095956
GO:0007162 negative regulation of cell adhesion IDA 9531558
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with RND1: view

Compounds for RND1 Gene

(1) HMDB Compounds for RND1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for RND1 Gene

Compound -log(P) Hits PubMed IDs
gdp 55.3 2
gtp 49.3 2
genes like me logo Genes that share compounds with RND1: view

Transcripts for RND1 Gene

mRNA/cDNA for RND1 Gene

(10) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RND1 Gene

Rho family GTPase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RND1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RND1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for RND1 Gene

GeneLoc Exon Structure for
RND1
ECgene alternative splicing isoforms for
RND1

Expression for RND1 Gene

mRNA expression in normal human tissues for RND1 Gene

mRNA differential expression in normal tissues according to GTEx for RND1 Gene

This gene is overexpressed in Liver (11.2), Brain - Cortex (4.9), and Brain - Frontal Cortex (BA9) (4.7).

SOURCE GeneReport for Unigene cluster for RND1 Gene Hs.124940

mRNA Expression by UniProt/SwissProt for RND1 Gene

Q92730-RND1_HUMAN
Tissue specificity: Mostly expressed in brain and liver
genes like me logo Genes that share expressions with RND1: view

In Situ Assay Products

No data available for Protein expression for RND1 Gene

Orthologs for RND1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RND1 35
  • 99.71 (n)
  • 100 (a)
RND1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RND1 35
  • 90.52 (n)
  • 98.71 (a)
RND1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RND1 35
  • 91.38 (n)
  • 98.71 (a)
RND1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnd1 35
  • 89.51 (n)
  • 96.55 (a)
Rnd1 16
Rnd1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnd1 35
  • 90.95 (n)
  • 96.55 (a)
lizard
(Anolis carolinensis)
Reptilia RND1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rho6-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rnd1 35
  • 73.71 (n)
  • 85.78 (a)
Str.10750 35
zebrafish
(Danio rerio)
Actinopterygii rnd1 36
  • 78 (a)
OneToMany
rnd1l 35
  • 75.86 (n)
  • 82.76 (a)
rnd1l 36
  • 83 (a)
OneToMany
Species with no ortholog for RND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RND1 Gene

ENSEMBL:
Gene Tree for RND1 (if available)
TreeFam:
Gene Tree for RND1 (if available)

Paralogs for RND1 Gene

Paralogs for RND1 Gene

Selected SIMAP similar genes for RND1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RND1: view

Variants for RND1 Gene

Sequence variations from dbSNP and Humsavar for RND1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1565933 -- 48,862,015(+) TTCTT(C/G)AGTGC reference, synonymous-codon
rs2270577 - 48,864,860(+) CGGTG(C/G)GCACA reference, missense
rs2446972 -- 48,862,375(-) TAGGA(C/G)ACCCA intron-variant
rs2446973 -- 48,858,384(-) gaaaa(A/G)aTAAT intron-variant
rs2446974 -- 48,857,077(-) ctttt(A/T)ttttt downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RND1 Gene

Variant ID Type Subtype PubMed ID
nsv826363 CNV Gain 20364138
nsv469373 CNV Loss 19166990
nsv832404 CNV Gain 17160897

Relevant External Links for RND1 Gene

HapMap Linkage Disequilibrium report
RND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RND1 Gene

Disorders for RND1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RND1 Gene including...

Search for RND1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RND1 Gene

genes like me logo Genes that share disorders with RND1: view

No data available for UniProtKB/Swiss-Prot for RND1 Gene

Publications for RND1 Gene

  1. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PMID: 9531558) Nobes C.D. … Chardin P. (J. Cell Biol. 1998) 2 3 4 23
  2. Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. (PMID: 10664463) Vayssiere B. … Camonis J. (FEBS Lett. 2000) 3 4 23
  3. Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. (PMID: 11095956) Aoki J. … Negishi M. (Biochem. Biophys. Res. Commun. 2000) 3 4 23
  4. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF- mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. (PMID: 12730235) Oinuma I. … Negishi M. (J. Biol. Chem. 2003) 3 4 23
  5. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. (PMID: 12842009) Wennerberg K. … Hansen S.H. (Curr. Biol. 2003) 3 23

Products for RND1 Gene

  • Addgene plasmids for RND1

Sources for RND1 Gene

Back to Top

Content