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RND1 Gene

protein-coding   GIFtS: 62
GCID: GC12M049250

Rho Family GTPase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Family GTPase 11 2 3     RHOS2
RHO62 3 5     GTP-Binding Protein2
Member S1     Ras Homolog Gene Family, Member S2
Ras Homolog Gene Family1     Rho-Related GTP-Binding Protein Rho62
ARHS2     Rnd13

External Ids:    HGNC: 183141   Entrez Gene: 272892   Ensembl: ENSG000001726027   OMIM: 6090385   UniProtKB: Q927303   

Export aliases for RND1 gene to outside databases

Previous GC identifers: GC12M047537 GC12M046283


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RND1 Gene:
Members of the Rho GTPase family, such as RND1, regulate the organization of the actin cytoskeleton in response to
extracellular growth factors (Nobes et al., 1998 (PubMed 9531558)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RND1 Gene:
RND1 (Rho family GTPase 1) is a protein-coding gene. Diseases associated with RND1 include alcoholic psychosis, and hantavirus pulmonary syndrome. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RHOB.

UniProtKB/Swiss-Prot: RND1_HUMAN, Q92730
Function: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls
rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by
disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body
with disruption of the cortical actin filaments

Gene Wiki entry for RND1 (Rnd1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RND1 gene promoter:
         NF-YA   Egr-4   NF-YB   POU2F1   CBF-A   CBF-B   POU2F1a   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRND1 promoter sequence
   Search Chromatin IP Primers for RND1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RND1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q12

RND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RND1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049250:  view genomic region     (about GC identifiers)

Start:
49,250,916 bp from pter      End:
49,259,681 bp from pter
Size:
8,766 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RND1_HUMAN, Q92730 (See protein sequence)
Recommended Name: Rho-related GTP-binding protein Rho6 precursor  
Size: 232 amino acids; 26056 Da
Subunit: Binds GRB7 and PLXNB1. Interacts with UBXD5. Interacts with PLXNA2
3 PDB 3D structures from and Proteopedia for RND1:
2CLS (3D)        2REX (3D)        3Q3J (3D)    
Secondary accessions: A8K9P7

Explore the universe of human proteins at neXtProt for RND1: NX_Q92730

Explore proteomics data for RND1 at MOPED


See RND1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_055285.1  
ENSEMBL proteins: 
 ENSP00000447059   ENSP00000308461   ENSP00000449045  
Reactome Protein details: Q92730

RND1 Human Recombinant Protein Products:

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Novus Biologicals RND1 Lysates
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ProSpec Recombinant Protein for RND1
Cloud-Clone Corp. Proteins for RND1

RND1 Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of RND1
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Novus Biologicals RND1 Antibodies
Abcam antibodies for RND1
Cloud-Clone Corp. Antibodies for RND1
ThermoFisher Antibodies for RND1
LSBio Antibodies in human, mouse, rat for RND1

RND1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for RND1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for RND1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for RND1
Cloud-Clone Corp. CLIAs for RND1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR005225 Small_GTP-bd_dom
 IPR001806 Small_GTPase
 IPR027417 P-loop_NTPase
 IPR003578 Small_GTPase_Rho

Graphical View of Domain Structure for InterPro Entry Q92730

ProtoNet protein and cluster: Q92730

2 Blocks protein domains:
IPB001806 Transforming protein P21 RAS signature
IPB003578 Ras small GTPase


UniProtKB/Swiss-Prot: RND1_HUMAN, Q92730
Similarity: Belongs to the small GTPase superfamily. Rho family


RND1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RND1_HUMAN, Q92730
Function: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls
rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by
disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body
with disruption of the cortical actin filaments

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003924GTPase activity NAS11095956
GO:0005102receptor binding IPI19843518
GO:0005515protein binding IPI10664463
GO:0005525GTP binding IEA--
     
RND1 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RND1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RND1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RND1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RND1

miRNA
Products:
    
miRTarBase miRNAs that target RND1:
hsa-mir-128-3p (MIRT021868)

Block miRNA regulation of human, mouse, rat RND1 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate RND1:
hsa-miR-199a-5p hsa-miR-199b-5p
SwitchGear 3'UTR luciferase reporter plasmidRND1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RND1
Predesigned siRNA for gene silencing in human, mouse, rat RND1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RND1

Clone
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OriGene clones in human, mouse for RND1 (see all 7)
OriGene ORF clones in mouse, rat for RND1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RND1 (NM_014470)
Sino Biological Human cDNA Clone for RND1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RND1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND1

Cell Line
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GenScript Custom overexpressing Cell Line Services for RND1
Browse ESI BIO Cell Lines and PureStem Progenitors for RND1 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RND1_HUMAN, Q92730: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton5
plasma membrane5
cytosol4
extracellular2
golgi apparatus1
mitochondrion1
peroxisome1

Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005829cytosol TAS--
GO:0005856cytoskeleton IEA--
GO:0005886plasma membrane IEA--
GO:0005912adherens junction IDA9531558

RND1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RND1 About   (see all 6)  
See pathways by source

SuperPathContained pathways About
1Semaphorin interactions
Sema4D in semaphorin signaling0.90
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion0.00
Sema4D induced cell migration and growth-cone collapse0.90
Sema4D mediated inhibition of cell attachment and migration0.00
Semaphorin interactions0.43
2L1CAM interactions
Axon guidance0.63
Developmental Biology0.63
3Development Slit Robo signaling
Neurophysiological process Receptor mediated axon growth repulsion0.41
4EPHB forward signaling
Cell adhesion Ephrins signaling0.30
5Semaphorin Signaling
Semaphorin Signaling

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for RND1
    Semaphorin Signaling

2 GeneGo (Thomson Reuters) Pathways for RND1
    Neurophysiological process Receptor-mediated axon growth repulsion
Cell adhesion Ephrins signaling


3 Reactome Pathways for RND1
    Sema4D induced cell migration and growth-cone collapse
Sema4D mediated inhibition of cell attachment and migration
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion


1 Kegg Pathway  (Kegg details for RND1):
    Axon guidance


RND1 for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RND1: 
          Notch Signaling Targets in human mouse rat
          Cardiotoxicity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for RND1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RND1 (Q927301, 2, 3 ENSP000003084614) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
InteractantInteraction Details
GeneCardExternal ID(s)
PLXNB1O431571, 2, 3, ENSP000002964404EBI-448618,EBI-1111488 MINT-16324 MINT-16325 I2D: score=6 STRING: ENSP00000296440
GRB7Q144511, 3, ENSP000003107714EBI-448618,EBI-970191 I2D: score=4 STRING: ENSP00000310771
FRS2Q8WU203, ENSP000002992934I2D: score=1 STRING: ENSP00000299293
ID3Q025353, ENSP000003636894I2D: score=1 STRING: ENSP00000363689
PDE6DO439243, ENSP000002876004I2D: score=4 STRING: ENSP00000287600
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006184GTP catabolic process NAS11095956
GO:0007015actin filament organization IDA11095956
GO:0007162negative regulation of cell adhesion IDA9531558
GO:0007165signal transduction ----
GO:0007264small GTPase mediated signal transduction IEA--

RND1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RND1

1 HMDB Compound for RND1    About this table
CompoundSynonyms CAS #PubMed Ids
Guanosine triphosphate5'-GTP (see all 10)86-01-1--

2 Novoseek inferred chemical compound relationships for RND1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gdp 55.3 2 16042565 (1), 9531558 (1)
gtp 49.3 3 16042565 (1), 10664463 (1)



RND1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RND1 gene: 
NM_014470.3  

Unigene Cluster for RND1:

Rho family GTPase 1
Hs.124940  [show with all ESTs]
Unigene Representative Sequence: AK124288
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000550607 ENST00000309739(uc001rsn.3) ENST00000548445 ENST00000553260
ENST00000551243
miRNA
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Block miRNA regulation of human, mouse, rat RND1 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate RND1:
hsa-miR-199a-5p hsa-miR-199b-5p
SwitchGear 3'UTR luciferase reporter plasmidRND1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RND1
Predesigned siRNA for gene silencing in human, mouse, rat RND1
Clone
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OriGene clones in human, mouse for RND1 (see all 7)
OriGene ORF clones in mouse, rat for RND1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RND1 (NM_014470)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RND1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RND1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RND1
OriGene qSTAR qPCR primer pairs in human, mouse for RND1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RND1
  QuantiTect SYBR Green Assays in human, mouse, rat RND1
  QuantiFast Probe-based Assays in human, mouse, rat RND1

Additional mRNA sequence: 

AB040147.1 AF498967.1 AK124288.1 AK292762.1 AL359573.1 BC026356.1 Y07923.1 

6 DOTS entries:

DT.105252  DT.95219010  DT.101956016  DT.121180519  DT.121180515  DT.91758283 

10 AceView cDNA sequences:

NM_014470 AL359573 BC026356 CR621792 CR604397 CR602286 AF498967 AK124288 
AB040147 Y07923 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RND1    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1:              -           -                                 
SP2:                          -                                 
SP3:                                                            


ECgene alternative splicing isoforms for RND1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTTCTCACCT
RND1 Expression
About this image


RND1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Brain (Nervous System)    fully expand to see all 16 entries
         Thalamus
         Septum   
RND1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RND1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.124940

UniProtKB/Swiss-Prot: RND1_HUMAN, Q92730
Tissue specificity: Mostly expressed in brain and liver

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RND1: 
          Notch Signaling Targets in human mouse rat
          Cardiotoxicity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for RND1
OriGene qSTAR qPCR primer pairs in human, mouse for RND1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RND1
QuantiTect SYBR Green Assays in human, mouse, rat RND1
QuantiFast Probe-based Assays in human, mouse, rat RND1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RND1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RND1 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnd11 , 5 Rho family GTPase 11, 5 89.51(n)1
96.55(a)1
  15 (54.65 cM)5
2238811  NM_172612.31  NP_766200.11 
 986634215 
lizard
(Anolis carolinensis)
Reptilia RND16
Rho family GTPase 1
86(a)
1 ↔ 1
2(94290846-94296865)
African clawed frog
(Xenopus laevis)
Amphibia rho6-prov2 GTP-binding protein 78.25(n)    BC055983.1 
zebrafish
(Danio rerio)
Actinopterygii rnd1l1 Rho family GTPase 1 like 75.86(n)
82.76(a)
  553414  NM_001044396.2  NP_001037861.1 


ENSEMBL Gene Tree for RND1 (if available)
TreeFam Gene Tree for RND1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RND1 gene
RHOB2  RHOA2  RHOD2  RHOF2  ENSG000002718102  RHOC2  RND32  RND22  
Selected SIMAP similar genes for RND1 using alignment to 3 protein entries:     RND1_HUMAN (see all proteins) (see all similar genes):
RND3    ARHE    RND2    RHOA    RHOC    RHOB
ARHA    RHOD    ARHG    RAC2    RHOG    RAC3
RHOJ    RAC1    RHOF    RHOU    RHOV    CDC42

RND1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RND1 (see all 237)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs24469741,2
C,F,A--49250860(-) cttttT/Attttt 1 -- ds50013Minor allele frequency- A:0.08NA 124
rs1891722871,2
--49251007(+) ACACTC/GCCCCC 1 -- ut310--------
rs788449331,2
C,F--49251172(+) GGACCC/GTGGGG 1 -- ut312Minor allele frequency- G:0.20CSA WA 120
rs733001771,2
C,F--49251331(+) CTGCCG/ACTCCA 1 -- ut312Minor allele frequency- A:0.04WA 120
rs1146887351,2
C,F--49251351(+) TCTCCG/ATTGCT 1 -- ut311Minor allele frequency- A:0.03WA 118
rs1925109771,2
--49251369(+) TAGAGA/GGGAAG 1 -- ut310--------
rs1443849161,2
C--49251523(+) GGAGC-/GGGGGG 1 -- ut310--------
rs1839469211,2
--49251601(+) CGTCAA/GGTCCT 1 -- ut310--------
rs1442055221,2
C--49251713(+) CCTCCC/TTCTCC 1 -- ut310--------
rs1881296001,2
C--49251740(+) CAAGGA/GAGGAA 1 -- ut310--------

HapMap Linkage Disequilibrium report for RND1 (49250916 - 49259681 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RND1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv469373CNV Loss19166990
nsv826363CNV Gain20364138
nsv832404CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RND1
DNA2.0 Custom Variant and Variant Library Synthesis for RND1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609038    OMIM disorders: --

10 diseases for RND1:    
About MalaCards
alcoholic psychosis    hantavirus pulmonary syndrome    mood disorder    t-cell leukemia
bipolar disorder    retinitis    endotheliitis    cerebritis
neuronitis    leukemia

1 disease from the University of Copenhagen DISEASES database for RND1:
Alcoholic psychosis

RND1 for disorders           About GeneDecksing


Export disorders for RND1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RND1 gene, integrated from 10 sources (see all 47):
(articles sorted by number of sources associating them with RND1)
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  1. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PubMed id 9531558)1, 2, 3, 9 Nobes C.D.... Chardin P. (J. Cell Biol. 1998)
  2. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF- mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. (PubMed id 12730235)1, 2, 9 Oinuma I.... Negishi M. (J. Biol. Chem. 2003)
  3. Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. (PubMed id 11095956)1, 2, 9 Aoki J.... Negishi M. (Biochem. Biophys. Res. Commun. 2000)
  4. Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. (PubMed id 10664463)1, 2, 9 Vayssiere B.... Camonis J. (FEBS Lett. 2000)
  5. Structure and function of the intracellular region of the plexin-B1 transmembrane receptor. (PubMed id 19843518)1, 2 Tong Y....Buck M. (J. Biol. Chem. 2009)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. (PubMed id 11940653)1, 2 Katoh H.... Negishi M. (Mol. Cell. Biol. 2002)
  8. Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. (PubMed id 15738000)1, 9 Harada A....Negishi M. (J. Biol. Chem. 2005)
  9. Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10. (PubMed id 18996843)1, 9 Li Y.H....PA1schel A.W. (J. Biol. Chem. 2009)
  10. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. (PubMed id 17916560)1, 9 Tong Y.... Buck M. (J. Biol. Chem. 2007)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 27289 HGNC: 18314 AceView: RND1 Ensembl:ENSG00000172602 euGenes: HUgn27289
ECgene: RND1 Kegg: 27289 H-InvDB: RND1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RND1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RND1 gene:
Search GeneIP for patents involving RND1

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