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Aliases for RNASET2 Gene

Aliases for RNASET2 Gene

  • Ribonuclease T2 2 3
  • RNASE6PL 3 4 6
  • Ribonuclease 6 3 4
  • EC 63
  • EC 3.1.27.- 4
  • BA514O12.3 3

External Ids for RNASET2 Gene

Previous GeneCards Identifiers for RNASET2 Gene

  • GC06M167252
  • GC06M167313
  • GC06M164815
  • GC06M167342

Summaries for RNASET2 Gene

Entrez Gene Summary for RNASET2 Gene

  • This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNASET2 Gene

RNASET2 (Ribonuclease T2) is a Protein Coding gene. Diseases associated with RNASET2 include leukoencephalopathy, cystic, without megalencephaly and alcohol-related neurodevelopmental disorder. GO annotations related to this gene include RNA binding and ribonuclease T2 activity. An important paralog of this gene is ENSG00000249141.

UniProtKB/Swiss-Prot for RNASET2 Gene

  • Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.

Gene Wiki entry for RNASET2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASET2 Gene

Genomics for RNASET2 Gene

Regulatory Elements for RNASET2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNASET2 Gene

166,929,504 bp from pter
166,957,191 bp from pter
27,688 bases
Minus strand

Genomic View for RNASET2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASET2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASET2 Gene

Proteins for RNASET2 Gene

  • Protein details for RNASET2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease T2
    Protein Accession:
    Secondary Accessions:
    • B2RDA7
    • E1P5C3
    • Q5T8Q0
    • Q8TCU2
    • Q9BZ46
    • Q9BZ47

    Protein attributes for RNASET2 Gene

    256 amino acids
    Molecular mass:
    29481 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASET2 Gene

    Alternative splice isoforms for RNASET2 Gene


neXtProt entry for RNASET2 Gene

Proteomics data for RNASET2 Gene at MOPED

Selected DME Specific Peptides for RNASET2 Gene

Post-translational modifications for RNASET2 Gene

  • Ubiquitination at Lys157
  • Glycosylation at Asn76, Asn106, and Asn212
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for RNASET2 Gene

Protein Domains for RNASET2 Gene


Suggested Antigen Peptide Sequences for RNASET2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O00584
  • Belongs to the RNase T2 family.
genes like me logo Genes that share domains with RNASET2: view

No data available for Gene Families for RNASET2 Gene

Function for RNASET2 Gene

Molecular function for RNASET2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by Zn(2+) and Cu(2+).
UniProtKB/Swiss-Prot Function:
Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism.

Enzyme Numbers (IUBMB) for RNASET2 Gene

Gene Ontology (GO) - Molecular Function for RNASET2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004521 endoribonuclease activity IBA --
GO:0004540 ribonuclease activity IDA 22735700
GO:0033897 ribonuclease T2 activity IEA --
genes like me logo Genes that share ontologies with RNASET2: view

Animal Model Products

miRNA for RNASET2 Gene

miRTarBase miRNAs that target RNASET2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASET2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNASET2 Gene

Localization for RNASET2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASET2 Gene

Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.

Subcellular locations from

Jensen Localization Image for RNASET2 Gene COMPARTMENTS Subcellular localization image for RNASET2 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
lysosome 5
vacuole 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNASET2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 9192857
GO:0005615 extracellular space IDA 16502470
GO:0005764 lysosome IDA 16620762
GO:0005788 endoplasmic reticulum lumen IDA 16620762
GO:0043202 lysosomal lumen IEA --
genes like me logo Genes that share ontologies with RNASET2: view

Pathways for RNASET2 Gene

SuperPathways for RNASET2 Gene

No Data Available

Interacting Proteins for RNASET2 Gene

Gene Ontology (GO) - Biological Process for RNASET2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process IDA 22735700
GO:0090501 RNA phosphodiester bond hydrolysis TAS 9192857
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASET2: view

No data available for Pathways by source for RNASET2 Gene

Transcripts for RNASET2 Gene

Unigene Clusters for RNASET2 Gene

Ribonuclease T2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASET2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASET2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP3: - - - - - - - -

Relevant External Links for RNASET2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASET2 Gene

mRNA expression in normal human tissues for RNASET2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASET2 Gene

This gene is overexpressed in Whole Blood (13.1) and Spleen (4.4).

Protein differential expression in normal tissues for RNASET2 Gene

This gene is overexpressed in Spleen (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNASET2 Gene

SOURCE GeneReport for Unigene cluster for RNASET2 Gene Hs.529989

mRNA Expression by UniProt/SwissProt for RNASET2 Gene

Tissue specificity: Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain.
genes like me logo Genes that share expressions with RNASET2: view

Expression partners for RNASET2 Gene

In Situ Assay Products

Orthologs for RNASET2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNASET2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNASET2 35
  • 71.94 (n)
  • 62.5 (a)
  • 51 (a)
(Canis familiaris)
Mammalia RNASET2 35
  • 75.5 (n)
  • 74.3 (a)
-- 36
  • 60 (a)
(Mus musculus)
Mammalia Rnaset2a 35
  • 77.83 (n)
  • 72.32 (a)
Rnaset2a 16
Rnaset2a 36
  • 64 (a)
Rnaset2b 36
  • 64 (a)
(Pan troglodytes)
Mammalia RNASET2 35
  • 99.61 (n)
  • 99.22 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rnaset2 35
  • 76.77 (n)
  • 71.95 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
(Gallus gallus)
Aves RNASET2 35
  • 65.45 (n)
  • 59.36 (a)
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnaset2 35
  • 61.97 (n)
  • 55.45 (a)
Str.9691 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7197 35
(Danio rerio)
Actinopterygii rnaset2 35
  • 56.84 (n)
  • 50.72 (a)
rnaset2 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009842 35
  • 45.02 (n)
  • 34.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta RNaseX25 35
  • 46.63 (n)
  • 34.68 (a)
RNaseX25 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea K10C9.3 35
  • 45.23 (n)
  • 32.43 (a)
K10C9.3 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RNY1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RNS3 35
  • 44.76 (n)
  • 33.14 (a)
(Oryza sativa)
Liliopsida Os08g0434100 35
  • 47.1 (n)
  • 34.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1740 36
  • 30 (a)
Species with no ortholog for RNASET2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNASET2 Gene

Gene Tree for RNASET2 (if available)
Gene Tree for RNASET2 (if available)

Paralogs for RNASET2 Gene

Paralogs for RNASET2 Gene

Selected SIMAP similar genes for RNASET2 Gene using alignment to 4 proteins: Pseudogenes for RNASET2 Gene

genes like me logo Genes that share paralogs with RNASET2: view

Variants for RNASET2 Gene

Sequence variations from dbSNP and Humsavar for RNASET2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11159 - 166,929,653(-) AGAGC(C/T)GGGGT reference, missense, utr-variant-3-prime
rs927392 -- 166,947,819(+) CGATT(A/G)ATGTG intron-variant
rs1044059 -- 166,956,409(-) GGGTC(G/T)CCAGG utr-variant-5-prime, upstream-variant-2KB
rs1077453 -- 166,946,536(+) CAATA(C/T)TTACT intron-variant
rs1079145 -- 166,947,236(-) ATCTT(C/T)TGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNASET2 Gene

Variant ID Type Subtype PubMed ID
esv2733211 CNV Deletion 23290073
esv2733212 CNV Deletion 23290073

Relevant External Links for RNASET2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASET2 Gene

Disorders for RNASET2 Gene

(1) OMIM Diseases for RNASET2 Gene (612944)


  • Leukoencephalopathy, cystic, without megalencephaly (LCWM) [MIM:612951]: An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. {ECO:0000269 PubMed:19525954}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for RNASET2 Gene

(5) Novoseek inferred disease relationships for RNASET2 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 37.3 3
colorectal cancer 16.5 2
cancer 14.9 4
metastasis 8.58 4
tumors 7.86 8

Relevant External Links for RNASET2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RNASET2: view

No data available for Genatlas for RNASET2 Gene

Publications for RNASET2 Gene

  1. Tumor and metastasis suppression by the human RNASET2 gene. (PMID: 15809705) Acquati F. … Taramelli R. (Int. J. Oncol. 2005) 3 4 23
  2. Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies. (PMID: 9192857) Trubia M. … Taramelli R. (Genomics 1997) 2 3 4
  3. Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer. (PMID: 11821951) Liu Y. … Ganesan T.S. (Oncogene 2002) 3 4
  4. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. (PMID: 16620762) Campomenosi P. … Taramelli R. (Arch. Biochem. Biophys. 2006) 3 4
  5. RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection. (PMID: 19525954) Henneke M. … Gartner J. (Nat. Genet. 2009) 3 4

Products for RNASET2 Gene

Sources for RNASET2 Gene

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