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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNASET2 Gene

protein-coding GIFtS: 51
GCID: GC06M167342

ribonuclease T2

Explore 17 diseases affiliated with
RNASET2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribonuclease T2¹ ²		FLJ10907¹
RNASE6PL¹ ² ³ ⁵		EC 3.1.27.-³
BA514O12.3¹		EC 3.1.27.1⁸
Ribonuclease 6² ³

External Ids:	HGNC: 21686¹	Entrez Gene: 8635²	Ensembl: ENSG00000026297⁷	OMIM: 612944⁵	UniProtKB: O00584³

Export aliases for RNASET2 gene to outside databases

Previous GC identifers: GC06M167252 GC06M167313 GC06M164815

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNASET2:

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a

single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584

Function: Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation

of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism

Gene Wiki entry for RNASET2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNASET2 gene promoter:
POU2F2 (Oct-2.1) POU2F2C MEF-2A POU2F1 POU2F1a Pax-2 aMEF-2 Pax-2a POU2F2B POU2F2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNASET2 promoter sequence

Search SABiosciences Chromatin IP Primers for RNASET2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASET2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

RNASET2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASET2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M167342: view genomic region (about GC identifiers)

Start:	167,342,992 bp from pter	End:	167,370,679 bp from pter
Size:	27,688 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584 (See protein sequence)

Recommended Name: Ribonuclease T2 precursor

Size: 256 amino acids; 29481 Da

Subcellular location: Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of

transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller

RNASET2 proteolytic products in the lysosome fraction

1 PDB 3D structure from and Proteopedia for RNASET2:

3T0O (3D)

Secondary accessions: B2RDA7 E1P5C3 Q5T8Q0 Q8TCU2 Q9BZ46 Q9BZ47

Alternative splicing: 2 isoforms: O00584-1 O00584-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RNASET2: NX_O00584

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00584

2 DME Specific Peptides for RNASET2 (O00584)

TIHGLWPD

HEWEKHGTC

RNASET2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003721.2

ENSEMBL proteins:

ENSP00000424947 ENSP00000426455 ENSP00000390833 ENSP00000422846 ENSP00000028008

ENSP00000426059

Human Recombinant Protein Products:

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	Novus Biologicals RNASET2 Protein Novus Biologicals RNASET2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RNASET2

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	9192857
GO:0005615	extracellular space	IDA	16620762
GO:0005764	lysosome	IDA	16620762
GO:0005788	endoplasmic reticulum lumen	IDA	16620762
GO:0043202	lysosomal lumen	IEA	--

RNASET2 for ontologies About GeneDecksing

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	ThermoFisher Antibodies for RNASET2

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	Uscn ELISAs and CLIAs for RNASET2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNASET2 for domains About GeneDecksing

2 InterPro domains/families:

IPR018188 RNase_T2_AS

IPR001568 RNase_T2-like

Graphical View of Domain Structure for InterPro Entry O00584

ProtoNet protein and cluster: O00584

1 Blocks protein family: IPB001568 Ribonuclease T2

UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584

Similarity: Belongs to the RNase T2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584

Function: Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation

of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism

Enzyme regulation: Inhibited by Zn(2+) and Cu(2+)

Enzyme Numbers (IUBMB): EC 3.1.27.-¹ EC 3.1.27.1²

miRNA Products:		OriGene 3'-UTR Clone: RNASET2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASET2
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RNASET2

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RNASET2
		Search LifeMap BioReagents cell lines for RNASET2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASET2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IEA	--
GO:0004540	ribonuclease activity	IDA	--
GO:0033897	ribonuclease T2 activity	IEA	--

RNASET2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNASET2

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006401	RNA catabolic process	IDA	--

RNASET2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNASET2
Search CenterWatch for drugs/clinical trials and news about RNASET2 / RNT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNASET2 gene:

NM_003730.4

Unigene Cluster for RNASET2:

Ribonuclease T2

Hs.529989 [show with all ESTs]

Unigene Representative Sequence: BC036282

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366855 ENST00000508775(uc003qve.3) ENST00000421787(uc003qvf.3)

ENST00000510083 ENST00000476238 ENST00000028008 ENST00000478180 ENST00000467705

ENST00000499370 ENST00000358165(uc003qvi.1) ENST00000496851 ENST00000509073

miRNA Products:		OriGene 3'-UTR Clone: RNASET2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASET2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RNASET2
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASET2 (see all 4) OriGene shRNA RFP: RNASET2 OriGene siRNA: RNASET2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASET2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASET2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASET2 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASET2 Browse OriGene validated miRNA SYBR primer pairs
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Additional cDNA sequence:

AJ419865.1 AK315467.1 BC001660.2 BC001819.2 BC036282.1 BC039713.1 BC051912.1 U85625.2

13 DOTS entries:

DT.451820 DT.40231793 DT.95313972 DT.95152397 DT.97843123 DT.121395918 DT.100796395 DT.75145653

DT.97843120 DT.95368640 DT.100796396 DT.100773560 DT.95125943

24/534 AceView cDNA sequences (see all 534):

AA515670 CA413076 CD674176 AW970144 BG054725 BC001819 CR593397 BC041056

CB243278 AW474688 AA338744 AW009717 BU682292 AI903930 CA418728 BQ712327

AI217287 BQ231009 AL041466 AI434681 AA962266 BE859050 CR623299 AW966270

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RNASET2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b
SP1:									-
SP2:
SP3:			-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for RNASET2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASET2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACCTGCGC

About this image
See RNASET2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASET2

SOURCE GeneReport for Unigene cluster: Hs.529989

UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584

Tissue specificity: Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain

SABiosciences Custom PCR Arrays for RNASET2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASET2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNASET2 gene from 9/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnaset2a^{1 , 5}	ribonuclease T2A^{1, 5}	75.85(n)¹ 69.29(a)¹		17 (4.87 cM)⁵ 100037283¹ NM_001083938.2¹ NP_001077407.1¹ 8128598⁵
chicken (Gallus gallus)	Aves	RNASET2¹	ribonuclease T2	62.67(n) 55.6(a)		421569 NM_001039491.1 NP_001034580.1
lizard (Anolis carolinensis)	Reptilia	--	--	56(a)	1 → many	1(225560723-225579333)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7197²	Xenopus laevis transcribed sequence with weak similarity more	79.95(n)		BU916882.1
zebrafish (Danio rerio)	Actinopterygii	rnaset2¹	ribonuclease T2	56.84(n) 50.72(a)		791890 NM_001030064.1 NP_001025235.1
fruit fly (Drosophila melanogaster)	Insecta	RNaseX25¹	Ribonuclease X25	47.29(n) 34.88(a)		38885 NM_079242.2 NP_523966.2
worm (Caenorhabditis elegans)	Secernentea	K10C9.3¹	Protein K10C9.3	45.44(n) 32.34(a)		190096 NM_070969.3 NP_503370.1
thale cress (Arabidopsis thaliana)	eudicotyledons	RNS3¹	ribonuclease 3	44.38(n) 33.73(a)		839225 NM_102446.2 NP_564264.1
rice (Oryza sativa)	Liliopsida	Os08g0434100¹	hypothetical protein	47.02(n) 35.27(a)		4345656 NM_001068412.1 NP_001061877.1

ENSEMBL Gene Tree for RNASET2 (if available)
TreeFam Gene Tree for RNASET2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNASET2 gene

ENSG00000249141²

1 SIMAP similar gene for RNASET2 using alignment to 4 protein entries: RNT2_HUMAN (see all proteins):

RNASE6PL

RNASET2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for RNASET2
PGOHUM00000250933

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73041468^1,2	C,F,	--	164815147(+)	`AGGACA/GCACCT`	1	--	ds500¹		4		WA CSA NA	242
rs73041471^1,2	C,	--	164815344(+)	`GCTCCG/AAGGGG`	1	--	ds500¹		3		WA NA	240
rs71571466^1,2	C,F,	--	164815379(+)	`GAATCG/AGTGCC`	1	--	ds500¹		2		NA	4
rs113535593^1,2	C	--	164815683(+)	`AAACTA/C/TGGGCA`	2	--	ut3¹		1		CSA	1
rs78667922^1,2	F,	--	164816312(+)	`AACAGG/ATATAT`	1	--	int¹		1		NA	120
rs57757562^1,2		--	164817668(+)	`TCACAA/GAAGAA`	1	--	int¹		0	--	--	--	--
rs76691958^1,2		--	164817670(+)	`ACAGAA/TGAAAG`	1	--	int¹		0	--	--	--	--
rs73256765^1,2	C,F,	--	164817726(+)	`CCCCCC/GTGTGC`	1	--	int¹		5		WA CSA	126
rs111479959^1,2	C,F,	--	164817779(+)	`GAGGGA/GGTCCT`	1	--	int¹		1		WA	118
rs77488359^1,2		--	164817934(+)	`CTGTCC/TACTCC`	1	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for RNASET2 (167342992 - 167370679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNASET2: --
Human Gene Mutation Database (HGMD): RNASET2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASET2

DNA2.0 Custom Variant and Variant Library Synthesis for RNASET2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNASET2 for disorders           About GeneDecksing

OMIM gene information: 612944
OMIM disorders: 612951
UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584

Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM) [MIM:612951]. An

infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic

abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows

multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination,

ventriculomegaly and intracranial calcifications

17 diseases for RNASET2: About MalaCards

leukoencephalopathy, cystic, without megalencephaly alcohol-related neurodevelopmental disorder megalencephaly congenital cytomegalovirus

intrahepatic cholangiocarcinoma epithelial ovarian cancer ovarian cancer vitiligo

microcephaly colorectal cancer crohn's disease cholangiocarcinoma

alcoholism ovarian carcinoma melanoma carcinoma

hepatitis

5 Novoseek disease relationships for RNASET2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian cancer	37.3	3	15809705 (1), 11314033 (1), 18543608 (1)
colorectal cancer	16.5	2	15309713 (1), 15329256 (1)
cancer	14.9	5	15309713 (1), 17109444 (1), 15329256 (1), 18543608 (1)
metastasis	8.58	4	15309713 (2), 15809705 (1), 15329256 (1)
tumors	7.86	12	11314033 (4), 15809705 (2), 17109444 (1), 18543608 (1)

Human Genome Epidemiology (HuGE) Navigator: RNASET2 (2 documents)

Export disorders for RNASET2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNASET2 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with RNASET2)

Utopia: connect your pdf to the dynamic
world of online information

Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies. (PubMed id 9192857)^{1, 2, 3} Trubia M.... Taramelli R. (1997)
Tumor and metastasis suppression by the human RNASET2 gene. (PubMed id 15809705)^{1, 2, 9} Acquati F....Taramelli R. (2005)
Structure and activity of the only human RNase T2. (PubMed id 22735700)^{1, 2} Thorn A.... Kratzner R. (2012)
rnaset2 mutant zebrafish model familial cystic leukoe ncephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. (PubMed id 21199949)^{1, 2} Haud N....Hurlstone A.F. (2011)
RNASET2-deficient cystic leukoencephalopathy resemble s congenital cytomegalovirus brain infection. (PubMed id 19525954)^{1, 2} Henneke M....GAortner J. (2009)
Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. (PubMed id 16620762)^{1, 2} Campomenosi P....Taramelli R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Physical and transcript map of the region between D6S264 and D6S149 on chromosome 6q27, the minimal region of allele loss in sporadic epithelial ovarian cancer. (PubMed id 11821951)^{1, 2} Liu Y.... Ganesan T.S. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8635	HGNC: 21686	AceView: RNASET2andRPS6KA2	Ensembl:ENSG00000026297	euGenes: HUgn8635
ECgene: RNASET2	H-InvDB: RNASET2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RNASET2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RNASET2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RNASET2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RNASET2 gene:
Search GeneIP for patents involving RNASET2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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ribonuclease T2

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