Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RNASET2 Gene

protein-coding   GIFtS: 60
GCID: GC06M167342

Ribonuclease T2

  See RNASET2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ribonuclease T21 2
RNASE6PL2 3 5
Ribonuclease 62 3
bA514O12.32
EC 3.1.27.-3
EC 3.1.27.18

External Ids:    HGNC: 216861   Entrez Gene: 86352   Ensembl: ENSG000000262977   OMIM: 6129445   UniProtKB: O005843   
ORGUL members:         

Export aliases for RNASET2 gene to outside databases

Previous GC identifers: GC06M167252 GC06M167313 GC06M164815


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RNASET2 Gene:
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a
single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement.
(provided by RefSeq, Jul 2008)

GeneCards Summary for RNASET2 Gene:
RNASET2 (ribonuclease T2) is a protein-coding gene. Diseases associated with RNASET2 include leukoencephalopathy, cystic, without megalencephaly, and alcohol-related neurodevelopmental disorder. GO annotations related to this gene include ribonuclease T2 activity and RNA binding. An important paralog of this gene is ENSG00000249141.

UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584
Function: Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal
degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism

Gene Wiki entry for RNASET2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASET2 gene promoter:
         POU2F2 (Oct-2.1)   POU2F2C   MEF-2A   POU2F1   POU2F1a   Pax-2   aMEF-2   Pax-2a   POU2F2B   POU2F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RNASET2 promoter sequence
   Search Chromatin IP Primers for RNASET2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASET2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

RNASET2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASET2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M167342:  view genomic region     (about GC identifiers)

Start:
167,342,992 bp from pter      End:
167,370,679 bp from pter
Size:
27,688 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584 (See protein sequence)
Recommended Name: Ribonuclease T2 precursor  
Size: 256 amino acids; 29481 Da
1 PDB 3D structure from and Proteopedia for RNASET2:
3T0O (3D)    
Secondary accessions: B2RDA7 E1P5C3 Q5T8Q0 Q8TCU2 Q9BZ46 Q9BZ47
Alternative splicing: 2 isoforms:  O00584-1   O00584-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for RNASET2: NX_O00584

Explore proteomics data for RNASET2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys157
  • Glycosylation2 at Asn76, Asn106, Asn212
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for RNASET2 (O00584)
     TIHGLWPD  HEWEKHGTC 


    See RNASET2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003721.2  
    ENSEMBL proteins: 
     ENSP00000424947   ENSP00000426455   ENSP00000390833   ENSP00000422846   ENSP00000028008  
     ENSP00000426059  

    RNASET2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RNASET2
    OriGene Protein Over-expression Lysate for RNASET2
    OriGene MassSpec for RNASET2
    OriGene Custom Protein Services for RNASET2
    GenScript Custom Purified and Recombinant Proteins Services for RNASET2
    Novus Biologicals RNASET2 Protein
    Novus Biologicals RNASET2 Lysates
    Sino Biological Recombinant Protein for RNASET2
    Sino Biological Cell Lysate for RNASET2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNASET2

     
    Search eBioscience for Proteins for RNASET2 

     
    antibodies-online proteins for RNASET2 (16 products) 

     
    antibodies-online peptides for RNASET2

    RNASET2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RNASET2
    OriGene Custom Antibody Services for RNASET2
    Novus Biologicals RNASET2 Antibodies
    Abcam antibodies for RNASET2
    Cloud-Clone Corp. Antibodies for RNASET2
    ThermoFisher Antibodies for RNASET2
    antibodies-online antibodies for RNASET2 (40 products) 

    RNASET2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNASET2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNASET2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNASET2
    Cloud-Clone Corp. CLIAs for RNASET2
    Search eBioscience for ELISAs for RNASET2 
    antibodies-online kits for RNASET2 (31 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR001568 RNase_T2-like
     IPR018188 RNase_T2_AS

    Graphical View of Domain Structure for InterPro Entry O00584

    ProtoNet protein and cluster: O00584

    1 Blocks protein domain: IPB001568 Ribonuclease T2

    UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584
    Similarity: Belongs to the RNase T2 family


    Find genes that share domains with RNASET2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNT2_HUMAN, O00584
    Function: Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal
    degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism
    Enzyme regulation: Inhibited by Zn(2+) and Cu(2+)

         Enzyme Numbers (IUBMB): EC 3.1.27.-1 EC 3.1.27.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0004540ribonuclease activity IDA--
    GO:0033897ribonuclease T2 activity IEA--
         
    Find genes that share ontologies with RNASET2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNASET2

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNASET2:
    hsa-mir-26b-5p (MIRT029082)

    Block miRNA regulation of human, mouse, rat RNASET2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RNASET2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNASET2
    Predesigned siRNA for gene silencing in human, mouse, rat RNASET2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNASET2

    Clone
    Products:
         
    OriGene clones in human, mouse for RNASET2 (see all 9)
    OriGene ORF clones in mouse, rat for RNASET2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASET2 (NM_003730)
    Sino Biological Human cDNA Clone for RNASET2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASET2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASET2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNASET2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNASET2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASET2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RNT2_HUMAN, O00584: Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of
    transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2
    smaller RNASET2 proteolytic products in the lysosome fraction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular5
    lysosome5
    vacuole5
    cytosol1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS9192857
    GO:0005615extracellular space IDA16620762
    GO:0005764lysosome IDA16620762
    GO:0005788endoplasmic reticulum lumen IDA16620762
    GO:0043202lysosomal lumen IEA--

    Find genes that share ontologies with RNASET2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASET2
    Interactions:

        Search GeneGlobe Interaction Network for RNASET2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for RNASET2 (ENSP000000280084) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2B2ENSP000002661264STRING: ENSP00000266126
    EIF2B4ENSP000003948694STRING: ENSP00000394869
    VAPAENSP000003456564STRING: ENSP00000345656
    VAPBENSP000004171754STRING: ENSP00000417175
    RTN1ENSP000002674844STRING: ENSP00000267484
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process IDA--
    GO:0090501RNA phosphodiester bond hydrolysis TAS9192857

    Find genes that share ontologies with RNASET2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASET2 (RNT2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RNASET2 gene: 
    NM_003730.4  

    Unigene Cluster for RNASET2:

    Ribonuclease T2
    Hs.529989  [show with all ESTs]
    Unigene Representative Sequence: BC036282
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366855 ENST00000508775(uc003qve.3) ENST00000421787(uc003qvf.3)
    ENST00000510083 ENST00000476238 ENST00000028008 ENST00000478180 ENST00000467705
    ENST00000499370 ENST00000358165(uc003qvi.1) ENST00000496851 ENST00000509073

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNASET2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RNASET2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNASET2
    Predesigned siRNA for gene silencing in human, mouse, rat RNASET2
    Clone
    Products:
         
    OriGene clones in human, mouse for RNASET2 (see all 9)
    OriGene ORF clones in mouse, rat for RNASET2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASET2 (NM_003730)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASET2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASET2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNASET2
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASET2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASET2
      QuantiTect SYBR Green Assays in human, mouse, rat RNASET2
      QuantiFast Probe-based Assays in human, mouse, rat RNASET2

    Additional mRNA sequence: 

    AJ419865.1 AK315467.1 BC001660.2 BC001819.2 BC036282.1 BC039713.1 BC051912.1 U85625.2 

    13 DOTS entries:

    DT.451820  DT.40231793  DT.95313972  DT.95152397  DT.97843123  DT.121395918  DT.100796395  DT.75145653 
    DT.97843120  DT.95368640  DT.100796396  DT.100773560  DT.95125943 

    Selected AceView cDNA sequences (see all 534):

    AA514262 AW582519 CN478672 BM708904 AA418652 AA947951 AI239566 BC019871 
    AA447507 NM_003730 AI952247 AI379056 BM699585 CF126690 BE293558 CN482650 
    AI809020 BC036282 CA309109 BF446274 AI016296 CB105063 BQ712473 AA223163 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RNASET2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                          -                                       
    SP2:                                                                  
    SP3:        -     -     -     -     -     -     -     -               


    ECgene alternative splicing isoforms for RNASET2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNASET2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACCTGCGC
    RNASET2 Expression
    About this image


    RNASET2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Lens
    RNASET2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASET2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529989

    UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584
    Tissue specificity: Ubiquitous. Higher expression levels observed in the temporal lobe and fetal brain

        Custom PCR Arrays for RNASET2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RNASET2
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASET2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASET2
    QuantiTect SYBR Green Assays in human, mouse, rat RNASET2
    QuantiFast Probe-based Assays in human, mouse, rat RNASET2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASET2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RNASET2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnaset2a1 , 5 ribonuclease T2A1, 5 77.83(n)1
    72.32(a)1
      17 (4.87 cM)5
    1000372831  NM_001083938.21  NP_001077407.11 
     81285985 
    chicken
    (Gallus gallus)
    Aves RNASET21 ribonuclease T2 65.45(n)
    59.36(a)
      421569  NM_001039491.1  NP_001034580.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    47(a)
    1 → many
    1(225557366-225580060)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.71972 Xenopus laevis transcribed sequence with weak similarity more 79.95(n)    BU916882.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rnaset21 ribonuclease T2 56.84(n)
    50.72(a)
      791890  NM_001030064.1  NP_001025235.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RNaseX251 Ribonuclease X25 46.63(n)
    34.68(a)
      38885  NM_079242.3  NP_523966.2 
    worm
    (Caenorhabditis elegans)
    Secernentea K10C9.31 K10C9.3 45.23(n)
    32.43(a)
      190096  NM_070969.4  NP_503370.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RNS31 RNS3 44.76(n)
    33.14(a)
      839225  NM_102446.2  NP_564264.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g04341001 Os08g0434100 47.1(n)
    34.24(a)
      4345656  NM_001068412.1  NP_001061877.1 


    ENSEMBL Gene Tree for RNASET2 (if available)
    TreeFam Gene Tree for RNASET2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RNASET2 gene
    ENSG000002491412  
    1 SIMAP similar gene for RNASET2 using alignment to 4 protein entries:     RNT2_HUMAN (see all proteins):
    RNASE6PL

    Find genes that share paralogs with RNASET2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RNASET2
    PGOHUM00000250933


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RNASET2 (see all 736)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0635964
    Leukoencephalopathy, cystic, without megalencephaly (LCWM)4--see VAR_0635962 C R mis40--------
    rs339711861,2
    C--164841158(+) AATCC-/CT    
       T
    /TCT
    TATTA
    2 -- cds10--------
    rs1444595871,2
    --164841285(+) GCTGC-/CACACAC 1 -- int10--------
    rs2013971391,2
    --164841300(+) ACACG-/CACACAC 1 -- int10--------
    rs2008922351,2
    --164841316(+) GCACA-/CACG  
            
    CACGC
    1 -- int10--------
    rs1440276811,2
    C--164841332(+) ACACG-/CGC   
       ACACA
    CGCAC
    1 -- int10--------
    rs1848032751,2
    C--164841337(+) CGCACA/GCACGC 1 -- int10--------
    rs77464841,2
    A--164841367(+) cacacA/Gcacac 1 -- int10--------
    rs1457656011,2
    C--164841368(+) ACACG-/CACACAC 1 -- int10--------
    rs715714681,2
    C--164841379(+) CACACA/GCGCGC 1 -- int13Minor allele frequency- G:0.25NA EA 242

    HapMap Linkage Disequilibrium report for RNASET2 (167342992 - 167370679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNASET2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733211CNV Deletion23290073
    esv2733212CNV Deletion23290073

    Human Gene Mutation Database (HGMD): RNASET2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASET2
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASET2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612944   
    OMIM disorders: 612951  
    UniProtKB/Swiss-Prot: RNT2_HUMAN, O00584
  • Leukoencephalopathy, cystic, without megalencephaly (LCWM) [MIM:612951]: An infantile-onset syndrome of
    cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including
    psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter
    lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and
    intracranial calcifications. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for RNASET2:    
    About MalaCards
    leukoencephalopathy, cystic, without megalencephaly    alcohol-related neurodevelopmental disorder    congenital cytomegalovirus    megalencephaly

    1 disease from the University of Copenhagen DISEASES database for RNASET2:
    alcohol-related neurodevelopmental disorder

    Find genes that share disorders with RNASET2           About GenesLikeMe

    5 Novoseek inferred disease relationships for RNASET2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 37.3 3 15809705 (1), 11314033 (1), 18543608 (1)
    colorectal cancer 16.5 2 15309713 (1), 15329256 (1)
    cancer 14.9 5 15309713 (1), 17109444 (1), 15329256 (1), 18543608 (1)
    metastasis 8.58 4 15309713 (2), 15809705 (1), 15329256 (1)
    tumors 7.86 12 11314033 (4), 15809705 (2), 17109444 (1), 18543608 (1)

    Genetic Association Database (GAD): RNASET2
    Human Genome Epidemiology (HuGE) Navigator: RNASET2 (2 documents)

    Export disorders for RNASET2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RNASET2 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with RNASET2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian Rh/T2/S-glycoprotein ribonuclease family genes: cloning of a human member located in a region of chromosome 6 (6q27) frequently deleted in human malignancies. (PubMed id 9192857)1, 2, 3 Trubia M.... Taramelli R. (Genomics 1997)
    2. Tumor and metastasis suppression by the human RNASET2 gene. (PubMed id 15809705)1, 2, 9 Acquati F....Taramelli R. (Int. J. Oncol. 2005)
    3. Structure and activity of the only human RNase T2. (PubMed id 22735700)1, 2 Thorn A.... Kratzner R. (Nucleic Acids Res. 2012)
    4. A genome-wide association study identifies two new risk loci for Graves' disease. (PubMed id 21841780)1, 4 Chu X....Song H.D. (Nat. Genet. 2011)
    5. rnaset2 mutant zebrafish model familial cystic leukoencephalopathy and reveal a role for RNase T2 in degrading ribosomal RNA. (PubMed id 21199949)1, 2 Haud N.... Hurlstone A.F. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    6. Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PubMed id 20601676)1, 4 Fransen K....Weersma R.K. (Hum. Mol. Genet. 2010)
    7. Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC. (PubMed id 20526339)1, 4 Quan C....Zhang X.J. (Nat. Genet. 2010)
    8. RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection. (PubMed id 19525954)1, 2 Henneke M.... Gartner J. (Nat. Genet. 2009)
    9. Characterization of RNASET2, the first human member of the Rh/T2/S family of glycoproteins. (PubMed id 16620762)1, 2 Campomenosi P.... Taramelli R. (Arch. Biochem. Biophys. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8635 HGNC: 21686 AceView: RNASET2andRPS6KA2 Ensembl:ENSG00000026297 euGenes: HUgn8635
    ECgene: RNASET2 H-InvDB: RNASET2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNASET2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNASET2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RNASET2 gene:
    Search GeneIP for patents involving RNASET2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RNASET2   OriGene RNAi products in human, mouse, rat for RNASET2  
     OriGene qPCR primer pairs and template standards for RNASET2   OriGene Protein Over-expression Lysate for RNASET2  
     OriGene MassSpec for RNASET2   OriGene clones in human, mouse for RNASET2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNASET2   OriGene Purified Protein for RNASET2  
     OriGene ORF clones in mouse, rat for RNASET2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNASET2   OriGene Custom Protein Services for RNASET2  

     
     
     Block miRNA regulation of human, mouse, rat RNASET2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNASET2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASET2 Predesigned siRNA for gene silencing in human, mouse, rat RNASET2
     QuantiFast Probe-based Assays in human, mouse, rat RNASET2 QuantiTect SYBR Green Assays in human, mouse, rat RNASET2
     Custom PCR Arrays for RNASET2 Search Chromatin IP Primers for RNASET2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASET2  Search GeneGlobe Interaction Network for RNASET2
     Regulatory tfbs in RNASET2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNASET2 GenScript cDNA clones with any tag delivered in your preferred vector for RNASET2
     GenScript Custom Assay Services for RNASET2 GenScript Custom overexpressing Cell Line Services for RNASET2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNASET2 (RNT2)
     Proteins for RNASET2
     Cell Lysates for RNASET2
     cDNA Clones for RNASET2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNASET2 antibodies
     RNASET2 proteins
     RNASET2 lysates
     Antibodies for RNASET2
     See all of Abcam's Antibodies, Kits and Proteins for RNASET2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNASET2
     Antibodies for RNASET2
     ELISAs for RNASET2
     CLIAs for RNASET2



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNASET2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASET2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RNASET2
     SwitchGear Promoter luciferase reporter plasmids for RNASET2
     ThermoFisher Antibodies for RNASET2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASET2
     Browse compounds at ApexBio
     Search Addgene for plasmids for RNASET2
      Search eBioscience for proteins for RNASET2
      Search eBioscience for elisas for RNASET2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for RNASET2
     antibodies-online antibodies for RNASET2 (40 products)
     antibodies-online kits for RNASET2 (31 products)
     antibodies-online peptides for RNASET2
     antibodies-online proteins for RNASET2 (16 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RNASET2 gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4