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Aliases for RNASEL Gene

Aliases for RNASEL Gene

  • Ribonuclease L 2 3 4
  • Ribonuclease L (2,5-Oligoisoadenylate Synthetase-Dependent) 2 3 5
  • 2-5A-Dependent RNase 3 4
  • Ribonuclease 4 3 4
  • RNase L 3 4
  • RNS4 3 4
  • 2,5-Oligoisoadenylate Synthetase-Dependent 3
  • Interferon-Induced 2-5A-Dependent RNase 3
  • Prostate Cancer 1 2
  • EC 3.1.26.- 4
  • PRCA1 3

External Ids for RNASEL Gene

Previous HGNC Symbols for RNASEL Gene

  • RNS4
  • PRCA1

Previous GeneCards Identifiers for RNASEL Gene

  • GC01M180070
  • GC01M177972
  • GC01M179063
  • GC01M179782
  • GC01M179274
  • GC01M180809
  • GC01M153780

Summaries for RNASEL Gene

Entrez Gene Summary for RNASEL Gene

  • This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNASEL Gene

RNASEL (Ribonuclease L) is a Protein Coding gene. Diseases associated with RNASEL include prostate cancer 1 and chronic fatigue syndrome. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include RNA binding and protein kinase activity. An important paralog of this gene is KIDINS220.

UniProtKB/Swiss-Prot for RNASEL Gene

  • Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831).

Gene Wiki entry for RNASEL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASEL Gene

Genomics for RNASEL Gene

Regulatory Elements for RNASEL Gene

Promoters for RNASEL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNASEL on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASEL Gene

Chromosome:
1
Start:
182,573,634 bp from pter
End:
182,589,285 bp from pter
Size:
15,652 bases
Orientation:
Minus strand

Genomic View for RNASEL Gene

Genes around RNASEL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASEL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASEL Gene

Proteins for RNASEL Gene

  • Protein details for RNASEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05823-RN5A_HUMAN
    Recommended name:
    2-5A-dependent ribonuclease
    Protein Accession:
    Q05823
    Secondary Accessions:
    • Q5W0L2
    • Q6AI46

    Protein attributes for RNASEL Gene

    Size:
    741 amino acids
    Molecular mass:
    83533 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL.

    Three dimensional structures from OCA and Proteopedia for RNASEL Gene

    Alternative splice isoforms for RNASEL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASEL Gene

Proteomics data for RNASEL Gene at MOPED

Post-translational modifications for RNASEL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNASEL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RNASEL Gene

Domains & Families for RNASEL Gene

Gene Families for RNASEL Gene

Protein Domains for RNASEL Gene

Graphical View of Domain Structure for InterPro Entry

Q05823

UniProtKB/Swiss-Prot:

RN5A_HUMAN :
  • The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain.
  • Belongs to the protein kinase superfamily.
  • Contains 9 ANK repeats.
Domain:
  • The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain.
  • The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.
  • The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity).
  • Contains 1 KEN domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily.
Similarity:
  • Contains 9 ANK repeats.
genes like me logo Genes that share domains with RNASEL: view

Function for RNASEL Gene

Molecular function for RNASEL Gene

GENATLAS Biochemistry:
ribonuclease L,2,5-oligoisoadenylate dependent,interferon regulated pathway
UniProtKB/Swiss-Prot CatalyticActivity:
Cleaves 3 of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.
UniProtKB/Swiss-Prot EnzymeRegulation:
After binding to 2-5A (5-phosphorylated 2,5-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding cassette (ABC) transporter family.
UniProtKB/Swiss-Prot Function:
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831).
UniProtKB/Swiss-Prot Induction:
By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2-5 oligoadenylate synthetases (OASs). oligoadenylate synthetase is stimulated by dsRNA to produce 5-phosphorylated, 2-5-linked oligoadenylates (2-5A), whose function is to activate RNASEL.

Enzyme Numbers (IUBMB) for RNASEL Gene

Gene Ontology (GO) - Molecular Function for RNASEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004521 endoribonuclease activity NAS 7514601
GO:0004540 ribonuclease activity IEA --
GO:0005524 ATP binding IEA --
GO:0043021 ribonucleoprotein complex binding IEA --
genes like me logo Genes that share ontologies with RNASEL: view
genes like me logo Genes that share phenotypes with RNASEL: view

Human Phenotype Ontology for RNASEL Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RNASEL Gene

MGI Knock Outs for RNASEL:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for RNASEL Gene

Localization for RNASEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASEL Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASEL Gene COMPARTMENTS Subcellular localization image for RNASEL gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 4
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RNASEL Gene

Pathways & Interactions for RNASEL Gene

genes like me logo Genes that share pathways with RNASEL: view

Pathways by source for RNASEL Gene

Gene Ontology (GO) - Biological Process for RNASEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,NAS 7514601
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0043488 regulation of mRNA stability IEA --
GO:0045444 fat cell differentiation IEA --
GO:0051607 defense response to virus IDA 19923450
genes like me logo Genes that share ontologies with RNASEL: view

No data available for SIGNOR curated interactions for RNASEL Gene

Drugs & Compounds for RNASEL Gene

(10) Drugs for RNASEL Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Pharma 32
Magnesium Nutra 0

(15) Additional Compounds for RNASEL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNASEL: view

Transcripts for RNASEL Gene

mRNA/cDNA for RNASEL Gene

Unigene Clusters for RNASEL Gene

Ribonuclease L (2,5-oligoisoadenylate synthetase-dependent):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNASEL Gene

No ASD Table

Relevant External Links for RNASEL Gene

GeneLoc Exon Structure for
RNASEL
ECgene alternative splicing isoforms for
RNASEL

Expression for RNASEL Gene

mRNA expression in normal human tissues for RNASEL Gene

mRNA differential expression in normal tissues according to GTEx for RNASEL Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for RNASEL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.5) and Cervix (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RNASEL Gene



SOURCE GeneReport for Unigene cluster for RNASEL Gene Hs.518545

mRNA Expression by UniProt/SwissProt for RNASEL Gene

Q05823-RN5A_HUMAN
Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with RNASEL: view

Protein tissue co-expression partners for RNASEL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNASEL Gene

Orthologs for RNASEL Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASEL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASEL 35
  • 80.09 (n)
  • 71.94 (a)
RNASEL 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNASEL 35
  • 80.45 (n)
  • 71.51 (a)
RNASEL 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnasel 35
  • 72.93 (n)
  • 64.71 (a)
Rnasel 16
Rnasel 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNASEL 35
  • 98.74 (n)
  • 97.3 (a)
RNASEL 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnasel 35
  • 72.82 (n)
  • 63.61 (a)
oppossum
(Monodelphis domestica)
Mammalia RNASEL 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNASEL 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNASEL 35
  • 55 (n)
  • 43.99 (a)
RNASEL 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNASEL 36
  • 44 (a)
OneToOne
Species with no ortholog for RNASEL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASEL Gene

ENSEMBL:
Gene Tree for RNASEL (if available)
TreeFam:
Gene Tree for RNASEL (if available)

Paralogs for RNASEL Gene

Paralogs for RNASEL Gene

(1) SIMAP similar genes for RNASEL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASEL: view

Variants for RNASEL Gene

Sequence variations from dbSNP and Humsavar for RNASEL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs486907 - 182,585,422(-) TGCCC(A/G)AAATG reference, missense
rs627928 - 182,582,202(-) GAGGA(G/T)CTGAA reference, missense
rs151296858 - 182,586,632(+) CCAGC(C/T)CCCTT reference, missense
rs145787003 - 182,585,590(+) GACAA(A/G)AGACT reference, missense
rs56250729 - 182,586,518(+) GAGGA(C/G/T)AAAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RNASEL Gene

Variant ID Type Subtype PubMed ID
nsv825531 CNV Loss 20364138
nsv825564 CNV Loss 20364138
esv1010175 CNV Deletion 20482838

Variation tolerance for RNASEL Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.78; 86.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASEL Gene

HapMap Linkage Disequilibrium report
RNASEL
Human Gene Mutation Database (HGMD)
RNASEL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASEL Gene

Disorders for RNASEL Gene

MalaCards: The human disease database

(9) MalaCards diseases for RNASEL Gene - From: OMIM, ClinVar, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer 1
  • prostate cancer, familial
chronic fatigue syndrome
  • cfs
prostate cancer
  • prostate cancer, hereditary, 5
west nile encephalitis
  • west nile fever encephalitis
male reproductive organ cancer
  • male genital cancer
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RN5A_HUMAN
  • Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. {ECO:0000305 PubMed:11799394, ECO:0000305 PubMed:11941539, ECO:0000305 PubMed:12415269, ECO:0000305 PubMed:17344846}.

Relevant External Links for RNASEL

Genetic Association Database (GAD)
RNASEL
Human Genome Epidemiology (HuGE) Navigator
RNASEL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASEL
genes like me logo Genes that share disorders with RNASEL: view

No data available for Genatlas for RNASEL Gene

Publications for RNASEL Gene

  1. Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. (PMID: 11941539) Roekman A. … Schleutker J. (Am. J. Hum. Genet. 2002) 3 4 23 48 67
  2. Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. (PMID: 20086112) Beuten J. … Leach R.J. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 23
  3. Endoribonuclease L (RNase L) regulates the myogenic and adipogenic potential of myogenic cells. (PMID: 19851509) Salehzada T. … Bisbal C. (PLoS ONE 2009) 3 23
  4. Nucleotide oligomerization domain-2 interacts with 2'-5'-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells. (PMID: 19853919) Dugan J.W. … Davey M.P. (Mol. Immunol. 2009) 3 23
  5. Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer. (PMID: 18575592) Madsen B.E. … Hansen L.L. (PLoS ONE 2008) 3 23

Products for RNASEL Gene

Sources for RNASEL Gene

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