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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNASEL Gene

protein-coding GIFtS: 66
GCID: GC01M182542

Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)

(Previous name: prostate cancer 1)
(Previous symbols: RNS4, PRCA1)

Microbiology & Infectious Diseases Congress

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)¹ ²		2',5'-Oligoisoadenylate Synthetase-Dependent²
RNS4¹ ² ³ ⁵		2-5A-Dependent Ribonuclease²
PRCA1¹ ² ⁵		Interferon-Induced 2-5A-Dependent RNase²
Ribonuclease 4² ³		EC 3.1.26.-³
2-5A-Dependent RNase² ³		Ribonuclease L³
RNase L² ³		HPC1⁵
Prostate Cancer 1¹

External Ids:	HGNC: 10050¹	Entrez Gene: 6041²	Ensembl: ENSG00000135828⁷	OMIM: 180435⁵	UniProtKB: Q05823³

Export aliases for RNASEL gene to outside databases

Previous GC identifers: GC01M180070 GC01M177972 GC01M179063 GC01M179782 GC01M179274 GC01M180809 GC01M153780

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNASEL Gene:

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and

antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to

prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. (provided by

RefSeq, Jul 2008)

GeneCards Summary for RNASEL Gene:

RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)) is a protein-coding gene. Diseases associated with RNASEL include chronic fatigue syndrome, and familial prostate cancer, and among its related super-pathways are Interferon Signaling and Influenza A. GO annotations related to this gene include endoribonuclease activity and RNA binding. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus

infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of

single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of

apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent

stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.

Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might

play a central role in the regulation of mRNA turnover

Gene Wiki entry for RNASEL Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_004487.19 NC_018912.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNASEL gene promoter:
AhR ER-alpha GATA-3 AP-1 ATF-2 AP-4 Arnt HNF-4alpha1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASEL promoter sequence

Search SABiosciences Chromatin IP Primers for RNASEL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASEL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25

RNASEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEL gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M182542: view genomic region (about GC identifiers)

Start:	182,542,769 bp from pter	End:	182,558,394 bp from pter
Size:	15,626 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823 (See protein sequence)

Recommended Name: 2-5A-dependent ribonuclease

Size: 741 amino acids; 83533 Da

Cofactor: Manganese or magnesium. Required for optimal RNA cleavage rates

Subunit: Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL

Subcellular location: Cytoplasm. Mitochondrion

3 PDB 3D structures from and Proteopedia for RNASEL:

1WDY (3D)

4G8K (3D)

4G8L (3D)

Secondary accessions: Q5W0L2

Explore the universe of human proteins at neXtProt for RNASEL: NX_Q05823

Explore proteomics data for RNASEL at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q05823

RNASEL Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_066956.1

ENSEMBL proteins:

ENSP00000356530 ENSP00000411147 ENSP00000440844

Reactome Protein details: Q05823
Human Recombinant Protein Products for RNASEL:

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	Novus Biologicals RNASEL Protein
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	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RNASEL

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--
GO:0016020	membrane	--	--

RNASEL for ontologies About GeneDecksing

RNASEL Antibody Products:

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	Novus Biologicals RNASEL Antibodies
	Abcam antibodies for RNASEL
	Cloud-Clone Corp. Antibodies for RNASEL
	ThermoFisher Antibodies for RNASEL
	LSBio Antibodies in human, mouse, rat for RNASEL

Assay Products for RNASEL:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RNASEL
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RNASEL Cloud-Clone Corp. CLIAs for RNASEL

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

ANKRD: Ankyrin repeat domain containing

5/6 InterPro protein domains (see all 6):

IPR000719 Prot_kinase_cat_dom

IPR020683 Ankyrin_rpt-contain_dom

IPR010513 KEN_dom

IPR006567 PUG-dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q05823

ProtoNet protein and cluster: Q05823

2 Blocks protein domains:

IPB006567 PUG

IPB010513 Ribonuclease 2-5A

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

Domain: The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain

Domain: The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization

Domain: The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is

sufficient for ribonuclease activity (By similarity)

Similarity: Belongs to the protein kinase superfamily

Similarity: Contains 9 ANK repeats

Similarity: Contains 1 KEN domain

Similarity: Contains 1 protein kinase domain

RNASEL for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RN5A_HUMAN, Q05823

Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus

infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of

single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of

apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent

stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.

Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might

play a central role in the regulation of mRNA turnover

Catalytic activity: Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete

products ranging from between 4 and 22 nucleotides in length

Enzyme regulation: After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and

subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding

cassette (ABC) transporter family

Induction: By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to

transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases (OASs). oligoadenylate

synthetase is stimulated by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose

function is to activate RNASEL

Genatlas biochemistry entry for RNASEL:

ribonuclease L,2',5'-oligoisoadenylate dependent,interferon regulated pathway

Enzyme Number (IUBMB): EC 3.1.26.-¹

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IDA	7514601
GO:0004521	endoribonuclease activity	NAS	7514601
GO:0004540	ribonuclease activity	--	--
GO:0004672	protein kinase activity	IEA	--
GO:0005515	protein binding	IPI	--

RNASEL for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for RNASEL:

Decreased substrate adherent c

Increased cell death HMECs cel

Synthetic lethal with gemcitab

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rnasel):

cellular

hematopoietic system

immune system

RNASEL for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Rnasel^tm1Slvm for RNASEL

inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASEL

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASEL

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASEL

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASEL

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASEL
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RNASEL (see all 10):
		hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b

		SwitchGear 3'UTR luciferase reporter plasmid: RNASEL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RNASEL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASEL

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RNASEL
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for RNASEL (see all 6) OriGene ORF clones in mouse, rat for RNASEL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RNASEL (NM_021133)
		Sino Biological Human cDNA Clone for RNASEL
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASEL
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RNASEL
		Search LifeMap BioReagents cell lines for RNASEL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RNASEL About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Interferon Signaling

Interferon Signaling

0.61

Cytokine Signaling in Immune system

0.61

Influenza A

Influenza A

0.34

Herpes simplex infection

0.33

Immune System

Immune System

0.56

Immune response IFN alpha/beta signaling pathway

Interferon alpha/beta signaling

0.45

Senescence and Autophagy

Senescence and Autophagy

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for RNASEL

Senescence and Autophagy

4 Reactome Pathways for RNASEL

	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	Interferon Signaling
	Immune System

3 Kegg Pathways (Kegg details for RNASEL):

	Hepatitis C
	Influenza A
	Herpes simplex infection

RNASEL for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RNASEL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for RNASEL (Q05823^{2, 3} ENSP00000356530⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IQGAP1	P46940²^,³, ENSP00000268182⁴	MINT-7990598 MINT-7990574 I2D: score=1 STRING: ENSP00000268182
ABCE1	P61221³, ENSP00000296577⁴	I2D: score=2 STRING: ENSP00000296577
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822
KIF23	Q02241², ENSP00000260363⁴	MINT-7990574 STRING: ENSP00000260363
GSPT1	P15170³	I2D: score=1

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006397	mRNA processing	IEA	--
GO:0006468	protein phosphorylation	NAS	7514601
GO:0009103	lipopolysaccharide biosynthetic process	--	--
GO:0019221	cytokine-mediated signaling pathway	TAS	--
GO:0045071	negative regulation of viral genome replication	IDA	19923450

RNASEL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RNASEL for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNASEL (RN5A)

2 HMDB Compounds for RNASEL About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--
Manganese	manganese	7439-96-5	--

10/23 Novoseek inferred chemical compound relationships for RNASEL gene (see all 23) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2',5'-oligoadenylate	96.3	177	11152576 (6), 15924878 (6), 11323422 (5), 20022497 (5) (see all 71)
8-methyladenosine	89.9	8	19749291 (3), 20022497 (3), 12757397 (1)
ecyd	87	43	18668243 (3), 18029773 (2), 12903334 (2), 17150838 (2) (see all 6)
ampligen	76.7	10	7893988 (5), 8148461 (2), 8099601 (1), 15357629 (1)
oligoribonucleotide	61.3	5	8617774 (2), 14604670 (1), 10726660 (1), 10474231 (1)
phosphorothioate	45.1	5	7685081 (2), 7890727 (2), 14583476 (1)
rrna	42.3	19	8017832 (2), 11152576 (2), 12903195 (2), 12903334 (2) (see all 7)
oligonucleotide	40.4	10	7679499 (2), 18950583 (1), 11878909 (1), 9111293 (1) (see all 8)
atp	32.9	9	15013441 (1), 9862963 (1), 15383904 (1), 18160405 (1) (see all 7)
ifn-alpha	27.5	11	17431428 (3), 11585831 (2)

Search CenterWatch for drugs/clinical trials and news about RNASEL / RN5A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNASEL gene:

NM_021133.3

Unigene Cluster for RNASEL:

Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Hs.518545 [show with all ESTs]

Unigene Representative Sequence: NM_021133

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367559(uc009wxz.2) ENST00000444138 ENST00000539397(uc009wya.1 uc001gpk.3)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASEL
		8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RNASEL (see all 10):
		hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b

		SwitchGear 3'UTR luciferase reporter plasmid: RNASEL 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASEL

Additional mRNA sequence:

AK315231.1 BC114433.1 BC115697.1 DQ352452.1

4 DOTS entries:

DT.211589 DT.86837487 DT.92002335 DT.425435

24/57 AceView cDNA sequences (see all 57):

CR627369 C01514 BQ216121 NM_021133 BX280477 AW016315 CA439592 AA258106

AA046353 BQ003187 AA377605 BI259008 AI669749 BX097443 BQ030219 BX502854

BE778138 BE349148 BP335764 CF143886 BG427155 BE049527 BQ948773 AA257976

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASEL expression in normal human tissues (normalized intensities) RNASEL embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCAATTAAAA

About this image

RNASEL expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/5 selected tissues (see all 5) fully expand


Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Myoblasts Mandibular Arch Muscles

Adipose (Muscoskeletal System)
Visceral White Adipose

Blood (Cardiovascular System)
Conventional Dendritic Cells II Spleen

Brain (Nervous System)
Adult Dopaminergic Neurons Ventral Tegmental Area

Spleen (Hematopoietic System)
Conventional Dendritic Cells II Spleen

See RNASEL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASEL

SOURCE GeneReport for Unigene cluster: Hs.518545

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine,

colon and peripheral blood leukocytes

SABiosciences Expression via Pathway-Focused PCR Array including RNASEL:

Polycomb & Trithorax Complexes in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASEL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RNASEL gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnasel^{1 , 5}	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)^{1, 5}	73.24(n)¹ 64.93(a)¹		1 (65.43 cM)⁵ 24014¹ NM_011882.2¹ NP_036012.1¹ 153749504⁵
chicken (Gallus gallus)	Aves	RNASEL¹	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	55(n) 43.99(a)		424410 NM_001031267.1 NP_001026438.1
lizard (Anolis carolinensis)	Reptilia	RNASEL⁶	Uncharacterized protein	44(a)	1 ↔ 1	GL343683.1(13053-33071)

ENSEMBL Gene Tree for RNASEL (if available)
TreeFam Gene Tree for RNASEL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNASEL gene

TANC2² ANKS3² ANKRD17² ANKRD29² FEM1A² ANKHD1² FANK1² KIDINS220²

ANKHD1-EIF4EBP3² FEM1B² TANC1² ANKS6² FEM1C²

1 SIMAP similar gene for RNASEL using alignment to 2 protein entries: RN5A_HUMAN (see all proteins):

DKFZp781D08126

RNASEL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74315364^1,2	C,F	pathogenic¹	189107374(-)	`ACATAG/TAGATT`	2	E *	stg¹		2		NA EU	5873
rs74315365^1,2	C	pathogenic¹	189108164(-)	`GTCATA/GGAGAG`	2	I M	mis¹		0	--	--	--	--
rs486907^1,2,4	C,F,O,A,H	other¹	189106782(-)	`TGCCCG/AAAATG`	2	/Q /R	mis¹ ese³		34		MN NS EA NA WA CSA EU	9296
rs73061339^1,2	C,F	--	182553014(+)	`ACCCAT/CCACTG`	1	--	int¹		3		WA CSA	121
rs589402^1,2	C,F,A,H	--	189094536(+)	`CACCAT/AGTGAG`	1	--	ds500¹		21		MN NS EA NA WA CSA	1704
rs112325086^1,2	C	--	189094556(+)	`TATGAA/TCTCTG`	1	--	ds500¹		2		CSA	3
rs188223507^1,2		--	189094585(+)	`AGAGAC/GAGGTA`	1	--	ds500¹		0	--	--	--	--
rs151012620^1,2	C	--	189094607(+)	`CTGCTA/GAGTAA`	1	--	ds500¹		0	--	--	--	--
rs193258729^1,2		--	189094658(+)	`AGAATC/TAGCCT`	1	--	ds500¹		0	--	--	--	--
rs73061324^1,2	C,F	--	189094705(+)	`TGAAAT/AGTTTG`	1	--	ds500¹		3		WA	122

HapMap Linkage Disequilibrium report for RNASEL (182542769 - 182558394 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RNASEL: About this table

Variant ID	Type	Subtype	PubMed ID
esv1010175	CNV	Deletion	20482838
nsv825531	CNV	Loss	20364138
nsv825564	CNV	Loss	20364138

Human Gene Mutation Database (HGMD): RNASEL

SABiosciences Cancer Mutation PCR Assays

SeqTarget long-range PCR primers for resequencing RNASEL

DNA2.0 Custom Variant and Variant Library Synthesis for RNASEL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 180435
OMIM disorders: 601518
UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition

to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic

ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include

small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell

carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and

neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene

represented in this entry

20/45 diseases for RNASEL (see all 45): About MalaCards

chronic fatigue syndrome familial prostate cancer prostate cancer parainfluenza virus type 3

myelitis prostatitis west nile virus lynch syndrome

biliary tract cancer hairy cell leukemia vaccinia hepatitis a

neuroendocrine carcinoma malignant glioma fibrosarcoma hiv type 1

dengue hemorrhagic fever herpes simplex hemorrhagic fever tonsillitis

2 diseases from the University of Copenhagen DISEASES database for RNASEL:

Chronic fatigue syndrome Prostate cancer

RNASEL for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

10/27 Novoseek inferred disease relationships for RNASEL gene (see all 27) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer, hereditary, 1	93.8	11	12590567 (1), 11799394 (1), 15604285 (1), 16241858 (1) (see all 8)
chronic fatigue syndrome	71.5	16	7893988 (2), 8148461 (2), 15924878 (2), 16277015 (2) (see all 11)
prostate cancer	65.7	125	12590567 (6), 20086112 (6), 16537704 (6), 18189233 (5) (see all 49)
virus infection	57.6	20	18029773 (2), 7679499 (2), 1374726 (1), 16235172 (1) (see all 13)
parainfluenza	43.1	2	9858317 (1), 17535916 (1)
fibrosarcoma	33.9	2	17055253 (2)
vesicular stomatitis	29.5	1	9858317 (1)
malignant glioma	22.7	1	11586885 (1)
cancer	22.7	13	16241858 (2), 18575592 (2), 15330212 (1), 15040862 (1) (see all 8)
immunodeficiency	17.6	7	9847332 (2), 7890727 (1), 18160405 (1)

Genetic Association Database (GAD): RNASEL
Human Genome Epidemiology (HuGE) Navigator: RNASEL (45 documents)

Export disorders for RNASEL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNASEL gene, integrated from 9 sources (see all 300):
(articles sorted by number of sources associating them with RNASEL)

Utopia: connect your pdf to the dynamic
world of online information

Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. (PubMed id 11941539)^{1, 2, 4, 9} Roekman A.... Schleutker J. (2002)
The 2-5A system in viral infection and apoptosis. (PubMed id 9856285)^{1, 2, 9} Castelli J.... Youle R.J. (1998)
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer. (PubMed id 18575592)^{1, 4, 9} Madsen B.E....Hansen L.L. (2008)
Alternative function of a protein kinase homology domain in 2', 5'- oligoadenylate dependent RNase L. (PubMed id 9862963)^{1, 2, 9} Dong B. and Silverman R.H. (1999)
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. (PubMed id 20086112)^{1, 4, 9} Beuten J....Leach R.J. (2010)
Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene. (PubMed id 15714208)^{1, 4, 9} Maier C....Paiss T. (2005)
Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases. (PubMed id 18767027)^{1, 4, 9} Robbins C.M....Kittles R.A. (2008)
RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans. (PubMed id 18189233)^{1, 4, 9} Shea P.R....Ferrell R.E. (2008)
RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients. (PubMed id 16537704)^{1, 4, 9} Orr-Urtreger A....Matzkin H. (2006)
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. (PubMed id 11799394)^{1, 2, 9} Carpten J.... Trent J. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6041	HGNC: 10050	AceView: RNASEL	Ensembl:ENSG00000135828	euGenes: HUgn6041
ECgene: RNASEL	Kegg: 6041	H-InvDB: RNASEL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNASEL	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RNASEL	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RNASEL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RNASEL gene:
Search GeneIP for patents involving RNASEL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)

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RNASEL Gene

Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)

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