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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASEL Gene

protein-coding   GIFtS: 66
GCID: GC01M182542

Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)

(Previous name: prostate cancer 1)
(Previous symbols: RNS4, PRCA1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)1 2     2',5'-Oligoisoadenylate Synthetase-Dependent2
RNS41 2 3 5     2-5A-Dependent Ribonuclease2
PRCA11 2 5     Interferon-Induced 2-5A-Dependent RNase2
Ribonuclease 42 3     EC 3.1.26.-3
2-5A-Dependent RNase2 3     Ribonuclease L3
RNase L2 3     HPC15
Prostate Cancer 11     

External Ids:    HGNC: 100501   Entrez Gene: 60412   Ensembl: ENSG000001358287   OMIM: 1804355   UniProtKB: Q058233   

Export aliases for RNASEL gene to outside databases

Previous GC identifers: GC01M180070 GC01M177972 GC01M179063 GC01M179782 GC01M179274 GC01M180809 GC01M153780


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNASEL Gene:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and
antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to
prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RNASEL Gene: 
RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)) is a protein-coding gene. Diseases associated with RNASEL include chronic fatigue syndrome, and familial prostate cancer, and among its related super-pathways are Interferon Signaling and Influenza A. GO annotations related to this gene include endoribonuclease activity and RNA binding. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus
infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of
single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of
apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent
stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.
Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might
play a central role in the regulation of mRNA turnover

Gene Wiki entry for RNASEL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASEL gene promoter:
         AhR   ER-alpha   GATA-3   AP-1   ATF-2   AP-4   Arnt   HNF-4alpha1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASEL promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASEL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASEL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

RNASEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M182542:  view genomic region     (about GC identifiers)

Start:
182,542,769 bp from pter      End:
182,558,394 bp from pter
Size:
15,626 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823 (See protein sequence)
Recommended Name: 2-5A-dependent ribonuclease  
Size: 741 amino acids; 83533 Da
Cofactor: Manganese or magnesium. Required for optimal RNA cleavage rates
Subunit: Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL
Subcellular location: Cytoplasm. Mitochondrion
3 PDB 3D structures from and Proteopedia for RNASEL:
1WDY (3D)        4G8K (3D)        4G8L (3D)    
Secondary accessions: Q5W0L2

Explore the universe of human proteins at neXtProt for RNASEL: NX_Q05823

Explore proteomics data for RNASEL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q05823

  • RNASEL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNASEL Protein Expression
    REFSEQ proteins: NP_066956.1  
    ENSEMBL proteins: 
     ENSP00000356530   ENSP00000411147   ENSP00000440844  
    Reactome Protein details: Q05823
    Human Recombinant Protein Products for RNASEL: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RNASEL
    GenScript Custom Purified and Recombinant Proteins Services for RNASEL
    Novus Biologicals RNASEL Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNASEL 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----

    RNASEL for ontologies           About GeneDecksing



    RNASEL Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of RNASEL
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    Novus Biologicals RNASEL Antibodies
    Abcam antibodies for RNASEL
    Cloud-Clone Corp. Antibodies for RNASEL 
    ThermoFisher Antibodies for RNASEL
    LSBio Antibodies in human, mouse, rat for RNASEL 

    Assay Products for RNASEL: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RNASEL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNASEL 
    Cloud-Clone Corp. CLIAs for RNASEL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ANKRD: Ankyrin repeat domain containing

    5/6 InterPro protein domains (see all 6):
     IPR000719 Prot_kinase_cat_dom
     IPR020683 Ankyrin_rpt-contain_dom
     IPR010513 KEN_dom
     IPR006567 PUG-dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q05823

    ProtoNet protein and cluster: Q05823

    2 Blocks protein domains:
    IPB006567 PUG
    IPB010513 Ribonuclease 2-5A


    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
    Domain: The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain
    Domain: The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization
    Domain: The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is
    sufficient for ribonuclease activity (By similarity)
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 9 ANK repeats
    Similarity: Contains 1 KEN domain
    Similarity: Contains 1 protein kinase domain


    RNASEL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN5A_HUMAN, Q05823
    Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus
    infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of
    single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of
    apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent
    stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.
    Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might
    play a central role in the regulation of mRNA turnover
    Catalytic activity: Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete
    products ranging from between 4 and 22 nucleotides in length
    Enzyme regulation: After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and
    subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding
    cassette (ABC) transporter family
    Induction: By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to
    transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases (OASs). oligoadenylate
    synthetase is stimulated by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose
    function is to activate RNASEL

         Genatlas biochemistry entry for RNASEL:
    ribonuclease L,2',5'-oligoisoadenylate dependent,interferon regulated pathway

         Enzyme Number (IUBMB): EC 3.1.26.-1

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA7514601
    GO:0004521endoribonuclease activity NAS7514601
    GO:0004540ribonuclease activity ----
    GO:0004672protein kinase activity IEA--
    GO:0005515protein binding IPI--
         
    RNASEL for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNASEL:
     Decreased substrate adherent c  Increased cell death HMECs cel  Synthetic lethal with gemcitab 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rnasel):
     cellular  hematopoietic system  immune system 

    RNASEL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rnaseltm1Slvm for RNASEL

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASEL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASEL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASEL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASEL 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASEL
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RNASEL (see all 10):
    hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidRNASEL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNASEL
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for RNASEL (see all 6)
    OriGene ORF clones in mouse, rat for RNASEL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASEL (NM_021133)
    Sino Biological Human cDNA Clone for RNASEL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASEL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEL
    Sirion Biotech Customized lentivirus for stable overexpression of RNASEL 
                         Customized lentivirus expression plasmids for stable overexpression of RNASEL 

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    Search LifeMap BioReagents cell lines for RNASEL
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNASEL About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    2Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    3Immune System
    Immune System0.56
    4Immune response IFN alpha/beta signaling pathway
    Interferon alpha/beta signaling0.45
    5Senescence and Autophagy
    Senescence and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RNASEL
        Senescence and Autophagy


    4        Reactome Pathways for RNASEL
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System


    3         Kegg Pathways  (Kegg details for RNASEL):
        Hepatitis C
    Influenza A
    Herpes simplex infection


    RNASEL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNASEL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for RNASEL (Q058232, 3 ENSP000003565304) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IQGAP1P469402, 3, ENSP000002681824MINT-7990598 MINT-7990574 I2D: score=1 STRING: ENSP00000268182
    ABCE1P612213, ENSP000002965774I2D: score=2 STRING: ENSP00000296577
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    KIF23Q022412, ENSP000002603634MINT-7990574 STRING: ENSP00000260363
    GSPT1P151703I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006468protein phosphorylation NAS7514601
    GO:0009103lipopolysaccharide biosynthetic process ----
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0045071negative regulation of viral genome replication IDA19923450

    RNASEL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNASEL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASEL (RN5A)

    2 HMDB Compounds for RNASEL    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    10/23 Novoseek inferred chemical compound relationships for RNASEL gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 96.3 177 11152576 (6), 15924878 (6), 11323422 (5), 20022497 (5) (see all 71)
    8-methyladenosine 89.9 8 19749291 (3), 20022497 (3), 12757397 (1)
    ecyd 87 43 18668243 (3), 18029773 (2), 12903334 (2), 17150838 (2) (see all 6)
    ampligen 76.7 10 7893988 (5), 8148461 (2), 8099601 (1), 15357629 (1)
    oligoribonucleotide 61.3 5 8617774 (2), 14604670 (1), 10726660 (1), 10474231 (1)
    phosphorothioate 45.1 5 7685081 (2), 7890727 (2), 14583476 (1)
    rrna 42.3 19 8017832 (2), 11152576 (2), 12903195 (2), 12903334 (2) (see all 7)
    oligonucleotide 40.4 10 7679499 (2), 18950583 (1), 11878909 (1), 9111293 (1) (see all 8)
    atp 32.9 9 15013441 (1), 9862963 (1), 15383904 (1), 18160405 (1) (see all 7)
    ifn-alpha 27.5 11 17431428 (3), 11585831 (2)

    Search CenterWatch for drugs/clinical trials and news about RNASEL / RN5A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNASEL gene: 
    NM_021133.3  

    Unigene Cluster for RNASEL:

    Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
    Hs.518545  [show with all ESTs]
    Unigene Representative Sequence: NM_021133
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367559(uc009wxz.2) ENST00000444138 ENST00000539397(uc009wya.1 uc001gpk.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RNASEL (see all 10):
    hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidRNASEL 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RNASEL (NM_021133)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASEL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEL
    Sirion Biotech Customized lentivirus for stable overexpression of RNASEL 
                         Customized lentivirus expression plasmids for stable overexpression of RNASEL 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASEL

    Additional mRNA sequence: 

    AK315231.1 BC114433.1 BC115697.1 DQ352452.1 

    4 DOTS entries:

    DT.211589  DT.86837487  DT.92002335  DT.425435 

    24/57 AceView cDNA sequences (see all 57):

    CR627369 C01514 BQ216121 NM_021133 BX280477 AW016315 CA439592 AA258106 
    AA046353 BQ003187 AA377605 BI259008 AI669749 BX097443 BQ030219 BX502854 
    BE778138 BE349148 BP335764 CF143886 BG427155 BE049527 BQ948773 AA257976 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASEL expression in normal human tissues (normalized intensities)      RNASEL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATTAAAA
    RNASEL Expression
    About this image


    RNASEL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Brain (Nervous System)
             Adult Dopaminergic Neurons Ventral Tegmental Area
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen

    See RNASEL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNASEL

    SOURCE GeneReport for Unigene cluster: Hs.518545

    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
    Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine,
    colon and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including RNASEL: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASEL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNASEL gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnasel1 , 5 ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)1, 5 73.24(n)1
    64.93(a)1
      1 (65.43 cM)5
    240141  NM_011882.21  NP_036012.11 
     1537495045 
    chicken
    (Gallus gallus)
    Aves RNASEL1 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 55(n)
    43.99(a)
      424410  NM_001031267.1  NP_001026438.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNASEL6
    Uncharacterized protein
    44(a)
    1 ↔ 1
    GL343683.1(13053-33071)


    ENSEMBL Gene Tree for RNASEL (if available)
    TreeFam Gene Tree for RNASEL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNASEL gene
    TANC22  ANKS32  ANKRD172  ANKRD292  FEM1A2  ANKHD12  FANK12  KIDINS2202  
    ANKHD1-EIF4EBP32  FEM1B2  TANC12  ANKS62  FEM1C2  
    1 SIMAP similar gene for RNASEL using alignment to 2 protein entries:     RN5A_HUMAN (see all proteins):
    DKFZp781D08126

    RNASEL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/439 SNPs in RNASEL are shown (see all 439)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743153641,2
    C,Fpathogenic1189107374(-) ACATAG/TAGATT 2 E * stg12Minor allele frequency- T:0.00NA EU 5873
    rs743153651,2
    Cpathogenic1189108164(-) GTCATA/GGAGAG 2 I M mis10--------
    rs4869071,2,4
    C,F,O,A,Hother1189106782(-) TGCCCG/AAAATG 2 /Q /R mis1 ese334Minor allele frequency- A:0.28MN NS EA NA WA CSA EU 9296
    rs730613391,2
    C,F--182553014(+) ACCCAT/CCACTG 1 -- int13Minor allele frequency- C:0.12WA CSA 121
    rs5894021,2
    C,F,A,H--189094536(+) CACCAT/AGTGAG 1 -- ds500121Minor allele frequency- A:0.06MN NS EA NA WA CSA 1704
    rs1123250861,2
    C--189094556(+) TATGAA/TCTCTG 1 -- ds50012Minor allele frequency- T:0.33CSA 3
    rs1882235071,2
    --189094585(+) AGAGAC/GAGGTA 1 -- ds50010--------
    rs1510126201,2
    C--189094607(+) CTGCTA/GAGTAA 1 -- ds50010--------
    rs1932587291,2
    --189094658(+) AGAATC/TAGCCT 1 -- ds50010--------
    rs730613241,2
    C,F--189094705(+) TGAAAT/AGTTTG 1 -- ds50013Minor allele frequency- A:0.05WA 122

    HapMap Linkage Disequilibrium report for RNASEL (182542769 - 182558394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNASEL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1010175CNV Deletion20482838
    nsv825531CNV Loss20364138
    nsv825564CNV Loss20364138


    Human Gene Mutation Database (HGMD): RNASEL
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASEL
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASEL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180435   
    OMIM disorders: 601518  
    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
  • Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition
    to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic
    ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include
    small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell
    carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and
    neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 20/45 diseases for RNASEL (see all 45):    About MalaCards
    chronic fatigue syndrome    familial prostate cancer    prostate cancer    parainfluenza virus type 3
    myelitis    prostatitis    west nile virus    lynch syndrome
    biliary tract cancer    hairy cell leukemia    vaccinia    hepatitis a
    neuroendocrine carcinoma    malignant glioma    fibrosarcoma    hiv type 1
    dengue hemorrhagic fever    herpes simplex    hemorrhagic fever    tonsillitis

    2 diseases from the University of Copenhagen DISEASES database for RNASEL:
    Chronic fatigue syndrome     Prostate cancer

    RNASEL for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/27 Novoseek inferred disease relationships for RNASEL gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer, hereditary, 1 93.8 11 12590567 (1), 11799394 (1), 15604285 (1), 16241858 (1) (see all 8)
    chronic fatigue syndrome 71.5 16 7893988 (2), 8148461 (2), 15924878 (2), 16277015 (2) (see all 11)
    prostate cancer 65.7 125 12590567 (6), 20086112 (6), 16537704 (6), 18189233 (5) (see all 49)
    virus infection 57.6 20 18029773 (2), 7679499 (2), 1374726 (1), 16235172 (1) (see all 13)
    parainfluenza 43.1 2 9858317 (1), 17535916 (1)
    fibrosarcoma 33.9 2 17055253 (2)
    vesicular stomatitis 29.5 1 9858317 (1)
    malignant glioma 22.7 1 11586885 (1)
    cancer 22.7 13 16241858 (2), 18575592 (2), 15330212 (1), 15040862 (1) (see all 8)
    immunodeficiency 17.6 7 9847332 (2), 7890727 (1), 18160405 (1)

    Genetic Association Database (GAD): RNASEL
    Human Genome Epidemiology (HuGE) Navigator: RNASEL (45 documents)

    Export disorders for RNASEL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASEL gene, integrated from 9 sources (see all 300):
    (articles sorted by number of sources associating them with RNASEL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. (PubMed id 11941539)1, 2, 4, 9 Roekman A.... Schleutker J. (2002)
    2. The 2-5A system in viral infection and apoptosis. (PubMed id 9856285)1, 2, 9 Castelli J.... Youle R.J. (1998)
    3. Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer. (PubMed id 18575592)1, 4, 9 Madsen B.E....Hansen L.L. (2008)
    4. Alternative function of a protein kinase homology domain in 2', 5'- oligoadenylate dependent RNase L. (PubMed id 9862963)1, 2, 9 Dong B. and Silverman R.H. (1999)
    5. Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. (PubMed id 20086112)1, 4, 9 Beuten J....Leach R.J. (2010)
    6. Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene. (PubMed id 15714208)1, 4, 9 Maier C....Paiss T. (2005)
    7. Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases. (PubMed id 18767027)1, 4, 9 Robbins C.M....Kittles R.A. (2008)
    8. RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans. (PubMed id 18189233)1, 4, 9 Shea P.R....Ferrell R.E. (2008)
    9. RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients. (PubMed id 16537704)1, 4, 9 Orr-Urtreger A....Matzkin H. (2006)
    10. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. (PubMed id 11799394)1, 2, 9 Carpten J.... Trent J. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6041 HGNC: 10050 AceView: RNASEL Ensembl:ENSG00000135828 euGenes: HUgn6041
    ECgene: RNASEL Kegg: 6041 H-InvDB: RNASEL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNASEL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNASEL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNASEL gene:
    Search GeneIP for patents involving RNASEL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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