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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASEL Gene

protein-coding   GIFtS: 62
GCID: GC01M182542

ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

(Previous name: prostate cancer 1 )
(Previous symbols: RNS4, PRCA1)
 Explore 47 diseases affiliated with
RNASEL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNASEL    

Aliases
for RNASEL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)1 2     2',5'-Oligoisoadenylate Synthetase-Dependent2
RNS41 2 3 5     2-5A-Dependent Ribonuclease2
PRCA11 2 5     Interferon-Induced 2-5A-Dependent RNase2
Ribonuclease 42 3     EC 3.1.26.-3
2-5A-Dependent RNase2 3     Ribonuclease L3
RNase L2 3     HPC15
Prostate Cancer 11     

External Ids:    HGNC: 100501   Entrez Gene: 60412   Ensembl: ENSG000001358287   OMIM: 1804355   UniProtKB: Q058233   

Export aliases for RNASEL gene to outside databases

Previous GC identifers: GC01M180070 GC01M177972 GC01M179063 GC01M179782 GC01M179274 GC01M180809 GC01M153780


Summaries
for RNASEL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RNASEL:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and
antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate
cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected
cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded
viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of
other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to
cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to
elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA
turnover

Gene Wiki entry for RNASEL


Genomic Views
for RNASEL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASEL gene promoter:
         AhR   ER-alpha   GATA-3   AP-1   ATF-2   AP-4   Arnt   HNF-4alpha1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASEL promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASEL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASEL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

RNASEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M182542:  view genomic region     (about GC identifiers)

Start:
 182,542,769 bp from pter      End:
 182,558,391 bp from pter
Size:
 15,623 bases      Orientation:
 minus strand

Proteins
for RNASEL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823 (See protein sequence)
Recommended Name: 2-5A-dependent ribonuclease  
Size: 741 amino acids; 83533 Da
Cofactor: Manganese or magnesium. Required for optimal RNA cleavage rates
Subunit: Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL
Subcellular location: Cytoplasm. Mitochondrion
3 PDB 3D structures from and Proteopedia for RNASEL:
1WDY (3D)        4G8K (3D)        4G8L (3D)    
Secondary accessions: Q5W0L2

Explore the universe of human proteins at neXtProt for RNASEL: NX_Q05823

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q05823

    • RNASEL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066956.1  
    ENSEMBL proteins: 
     ENSP00000356530   ENSP00000411147   ENSP00000440844  
    Reactome Protein details: Q05823
    Human Recombinant Protein Products: 
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    Novus Biologicals RNASEL Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RNASEL

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--


    RNASEL for ontologies           About GeneDecksing



    RNASEL Antibody Products: 
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    Uscn Antibodies for RNASEL
    ThermoFisher Antibodies for RNASEL

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    Uscn ELISAs and CLIAs for RNASEL

    Protein Domains /
    Families
    for RNASEL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNASEL for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR020683 Ankyrin_rpt-contain_dom
     IPR010513 KEN_dom
     IPR006567 PUG-dom

    Graphical View of Domain Structure for InterPro Entry Q05823

    ProtoNet protein and cluster: Q05823

    2 Blocks protein families:
    IPB006567 PUG
    IPB010513 Ribonuclease 2-5A


    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
    Domain: The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain
    Domain: The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization
    Domain: The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient
    for ribonuclease activity (By similarity)
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 9 ANK repeats
    Similarity: Contains 1 KEN domain
    Similarity: Contains 1 protein kinase domain


    Function
    for RNASEL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
    Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected
    cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded
    viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of
    other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to
    cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to
    elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA
    turnover
    Catalytic activity: Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products
    ranging from between 4 and 22 nucleotides in length
    Enzyme regulation: After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and
    subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding
    cassette (ABC) transporter family
    Induction: By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe
    genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases (OASs). oligoadenylate synthetase is
    stimulated by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose function is to activate
    RNASEL

         Genatlas biochemistry entry for RNASEL:
    ribonuclease L,2',5'-oligoisoadenylate dependent,interferon regulated pathway

    Enzyme Number (IUBMB): EC 3.1.26.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASEL
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate RNASEL (see all 10):
    hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmid: RNASEL 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASEL (see all 7)
    OriGene shRNA RFP: RNASEL
    OriGene siRNA: RNASEL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASEL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RNASEL

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASEL (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RNASEL (NM_021133)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEL 

    Cell Line
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    Search LifeMap BioReagents cell lines for RNASEL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA7514601
    GO:0004521endoribonuclease activity NAS7514601
    GO:0004672protein kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016891endoribonuclease activity, producing 5'-phosphomonoesters IEA--


    RNASEL for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RNASEL:
     Decreased substrate adherent c  Increased cell death HMECs cel  Synthetic lethal with gemcitab 

    Animal Models:
         Mouse knock-out Rnaseltm1Slvm for RNASEL
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rnasel):
     cellular  hematopoietic system  immune system 

    RNASEL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RNASEL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61
    2Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    3Immune System
    		Immune System1.00
    4Senescence and Autophagy
    		Senescence and Autophagy1.00
    5Hepatitis C
    		Hepatitis C1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for RNASEL 
        Senescence and Autophagy

    5        Reactome Pathways for RNASEL
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Expression of IFN-induced genes
    Interferon Signaling
    Immune System


    2         Kegg Pathways  (Kegg details for RNASEL):
        Hepatitis C
    Influenza A


    RNASEL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNASEL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for RNASEL (Q058232, 3 ENSP000003565304) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IQGAP1P469402, 3, ENSP000002681824MINT-7990598 MINT-7990574 I2D: score=1 STRING: ENSP00000268182
    ABCE1P612213, ENSP000002965774I2D: score=2 STRING: ENSP00000296577
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    KIF23Q022412, ENSP000002603634MINT-7990574 STRING: ENSP00000260363
    GSPT1P151703I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006468protein phosphorylation NAS7514601
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0045071negative regulation of viral genome replication IDA19923450
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA19245366


    RNASEL for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNASEL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNASEL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASEL

    2 HMDB Compounds for RNASEL    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--
    10/23 Novoseek chemical compound relationships for RNASEL gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 96.3 177 11152576 (6), 15924878 (6), 11323422 (5), 20022497 (5) (see all 71)
    8-methyladenosine 89.9 8 19749291 (3), 20022497 (3), 12757397 (1)
    ecyd 87 43 18668243 (3), 18029773 (2), 12903334 (2), 17150838 (2) (see all 6)
    ampligen 76.7 10 7893988 (5), 8148461 (2), 8099601 (1), 15357629 (1)
    oligoribonucleotide 61.3 5 8617774 (2), 14604670 (1), 10726660 (1), 10474231 (1)
    phosphorothioate 45.1 5 7685081 (2), 7890727 (2), 14583476 (1)
    rrna 42.3 19 8017832 (2), 11152576 (2), 12903195 (2), 12903334 (2) (see all 7)
    oligonucleotide 40.4 10 7679499 (2), 18950583 (1), 11878909 (1), 9111293 (1) (see all 8)
    atp 32.9 9 15013441 (1), 9862963 (1), 15383904 (1), 18160405 (1) (see all 7)
    ifn-alpha 27.5 11 17431428 (3), 11585831 (2)

    Search CenterWatch for drugs/clinical trials and news about RNASEL / RN5A 

    Transcripts
    for RNASEL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNASEL gene: 
    NM_021133.3  

    Unigene Cluster for RNASEL:

    Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
    Hs.518545  [show with all ESTs]
    Unigene Representative Sequence: NM_021133
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367559(uc009wxz.2) ENST00000444138 ENST00000539397(uc009wya.1 uc001gpk.3)


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    hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmid: RNASEL 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASEL (see all 7)
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASEL

    Additional cDNA sequence: 

    AK315231.1 BC114433.1 BC115697.1 DQ352452.1 

    4 DOTS entries:

    DT.211589  DT.86837487  DT.92002335  DT.425435 

    24/57 AceView cDNA sequences (see all 57):

    BX280477 AW016315 C01514 CR627369 NM_021133 BQ216121 CF143886 W92226 
    CF527913 BX502854 AW138018 BE778138 AW968304 AA377605 AI669749 AA046353 
    BX097443 AA902343 BP335764 BI259008 BQ003187 BG427155 BP336508 CA439592 

    GeneLoc Exon Structure


    Expression
    for RNASEL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASEL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAATTAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RNASEL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNASEL

    SOURCE GeneReport for Unigene cluster: Hs.518545

    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
    Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon
    and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including RNASEL: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASEL
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL

    Orthologs
    for RNASEL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RNASEL gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnasel1 , 5 ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)1, 5 73.24(n)1
    64.93(a)1    		   1 (65.43 cM)5
    240141  NM_011882.21  NP_036012.11 
     1537494265 
    chicken
    (Gallus gallus)    		 Aves RNASEL1 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 55(n)
    43.99(a)    		   424410  NM_001031267.1  NP_001026438.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RNASEL6
    		 --
    		 43(a)
    		 1 ↔ 1
    		 GL343683.1(13863-28804)


    ENSEMBL Gene Tree for RNASEL (if available)
    TreeFam Gene Tree for RNASEL (if available) 

    Paralogs
    for RNASEL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RNASEL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/346 NCBI SNPs in RNASEL are shown (see all 346)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs743153651,2
    		Cpathogenic200418095(-) GTCATA/GGAGAG 2 I M mis10--------
    rs743153641,2
    		C,F,pathogenic200418885(-) ACATAG/TAGATT 2 E * stg12Minor allele frequency- T:0.00NA EU 5873
    rs4869071,2
    		C,F,O,A,H,other200419477(-) TGCCCG/AAAATG 2 /Q /R mis1 ese334Minor allele frequency- A:0.28MN NS EA NA WA CSA EU 9296
    rs730613241,2
    		C,F,--153778946(+) TGAAAT/AGTTTG 1 -- ds50013Minor allele frequency- A:0.05WA 122
    rs1150443801,2
    		C,F,--153779864(+) CCATCG/ACCCGT 1 -- ut311Minor allele frequency- A:0.07WA 118
    rs1117050021,2
    		--153780251(+) GCCATT/AGCATG 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs168592441,2
    		C,--153781742(+) ATTACT/GTTTCT 1 -- int1 trp33Minor allele frequency- G:0.01NA 142
    rs40478601,2
    		C,--153782791(+) aaattA/Taaaaa 1 -- int12Minor allele frequency- T:0.13NA WA 120
    rs1139785881,2
    		--153783288(+) TAAGGG/AAAAAA 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs763919091,2
    		C,F,--153785105(+) NNNNAC/TGCCAA 1 -- int11Minor allele frequency- T:0.02NA 120

    HapMap Linkage Disequilibrium report for RNASEL (182542769 - 182558391 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RNASEL: --
    Human Gene Mutation Database (HGMD): RNASEL

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASEL
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASEL

    Disorders / Diseases
    for RNASEL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNASEL for disorders           About GeneDecksing

    OMIM gene information: 180435   
    OMIM disorders: 601518  
    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
  • Defects in RNASEL are a cause of susceptibility to prostate cancer hereditary type 1 (HPC1) [MIM:601518]. It
    • is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are
    adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer
    that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal
    carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma
    (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma

    20/47 diseases for RNASEL (see all 47):    About MalaCards
    prostate cancer    prostatitis    prostate cancer 1, 176807    parainfluenza virus type 3
    west nile virus    dengue hemorrhagic fever    chronic fatigue syndrome    hemorrhagic fever
    biliary tract cancer    herpes simplex    hairy cell leukemia    malignant glioma
    myelitis    lynch syndrome    transitional cell carcinoma    basal cell carcinoma
    hepatitis c    stomatitis    hepatitis a    fibrosarcoma

    2 diseases from the University of Copenhagen DISEASES database for RNASEL:
    Chronic fatigue syndrome     Prostate cancer

    10/27 Novoseek disease relationships for RNASEL gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer, hereditary, 1 93.8 11 12590567 (1), 11799394 (1), 15604285 (1), 16241858 (1) (see all 8)
    chronic fatigue syndrome 71.5 16 7893988 (2), 8148461 (2), 15924878 (2), 16277015 (2) (see all 11)
    prostate cancer 65.7 125 12590567 (6), 20086112 (6), 16537704 (6), 18189233 (5) (see all 49)
    virus infection 57.6 20 18029773 (2), 7679499 (2), 1374726 (1), 16235172 (1) (see all 13)
    parainfluenza 43.1 2 9858317 (1), 17535916 (1)
    fibrosarcoma 33.9 2 17055253 (2)
    vesicular stomatitis 29.5 1 9858317 (1)
    malignant glioma 22.7 1 11586885 (1)
    cancer 22.7 13 16241858 (2), 18575592 (2), 15330212 (1), 15040862 (1) (see all 8)
    immunodeficiency 17.6 7 9847332 (2), 7890727 (1), 18160405 (1)

    Genetic Association Database (GAD): RNASEL
    Human Genome Epidemiology (HuGE) Navigator: RNASEL (45 documents)

    Export disorders for RNASEL gene to outside databases

    Publications
    for RNASEL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASEL gene, integrated from 9 sources (see all 288):
    (articles sorted by number of sources associating them with RNASEL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. (PubMed id 11941539)1, 2, 4, 9 Roekman A.... Schleutker J. (2002)
    2. The 2-5A system in viral infection and apoptosis. (PubMed id 9856285)1, 2, 9 Castelli J.... Youle R.J. (1998)
    3. Alternative function of a protein kinase homology domain in 2', 5'- oligoadenylate dependent RNase L. (PubMed id 9862963)1, 2, 9 Dong B. and Silverman R.H. (1999)
    4. Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene. (PubMed id 15714208)1, 4, 9 Maier C....Paiss T. (2005)
    5. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. (PubMed id 11799394)1, 2, 9 Carpten J.... Trent J. (2002)
    6. The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. (PubMed id 11585831)1, 2, 9 Le Roy F....Salehzada T. (2001)
    7. Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. (PubMed id 11333017)1, 2, 9 Dong B.... Silverman R.H. (2001)
    8. Genetic analysis of the RNASEL gene in hereditary, familial, and sporadic prostate cancer. (PubMed id 15534086)1, 4, 9 Wiklund F....Gronberg H. (2004)
    9. Role of genetic polymorphisms of the RNASEL gene on familial prostate cancer risk in a Japanese population. (PubMed id 12915880)1, 4, 9 Nakazato H....Yamanaka H. (2003)
    10. Intrinsic molecular activities of the interferon-induced 2-5A- dependent RNase. (PubMed id 7514601)1, 2, 9 Dong B....Silverman R.H. (1994)

    External Searches for RNASEL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing RNASEL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6041 HGNC: 10050 AceView: RNASEL Ensembl:ENSG00000135828 euGenes: HUgn6041
    ECgene: RNASEL Kegg: 6041 H-InvDB: RNASEL

    Other Databases showing RNASEL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNASEL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNASEL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNASEL Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RNASEL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNASEL gene:
    Search GeneIP for patents involving RNASEL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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