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RNASEL Gene

protein-coding GIFtS: 66
GCID: GC01M182542

Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)

(Previous name: prostate cancer 1)
(Previous symbols: RNS4, PRCA1)

Microbiology & Infectious Diseases Congress

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)¹ ²		2',5'-Oligoisoadenylate Synthetase-Dependent²
RNS4¹ ² ³ ⁵		2-5A-Dependent Ribonuclease²
PRCA1¹ ² ⁵		Interferon-Induced 2-5A-Dependent RNase²
Ribonuclease 4² ³		EC 3.1.26.-³
2-5A-Dependent RNase² ³		Ribonuclease L³
RNase L² ³		HPC1⁵
Prostate Cancer 1¹

External Ids:	HGNC: 10050¹	Entrez Gene: 6041²	Ensembl: ENSG00000135828⁷	OMIM: 180435⁵	UniProtKB: Q05823³

Export aliases for RNASEL gene to outside databases

Previous GC identifers: GC01M180070 GC01M177972 GC01M179063 GC01M179782 GC01M179274 GC01M180809 GC01M153780

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNASEL Gene:

This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and

antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to

prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. (provided by

RefSeq, Jul 2008)

GeneCards Summary for RNASEL Gene:

RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)) is a protein-coding gene. Diseases associated with RNASEL include chronic fatigue syndrome, and prostate cancer 1. GO annotations related to this gene include endoribonuclease activity and RNA binding.

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus

infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of

single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of

apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent

stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.

Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might

play a central role in the regulation of mRNA turnover

Gene Wiki entry for RNASEL Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_004487.20 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the RNASEL gene promoter:
AhR ER-alpha GATA-3 AP-1 ATF-2 AP-4 Arnt HNF-4alpha1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASEL promoter sequence

Search Chromatin IP Primers for RNASEL

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASEL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25 Ensembl cytogenetic band: 1q25.3 HGNC cytogenetic band: 1q25

RNASEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEL gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M182542: view genomic region (about GC identifiers)

Start:	182,542,769 bp from pter	End:	182,558,394 bp from pter
Size:	15,626 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823 (See protein sequence)

Recommended Name: 2-5A-dependent ribonuclease

Size: 741 amino acids; 83533 Da

Cofactor: Manganese or magnesium. Required for optimal RNA cleavage rates

Subunit: Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL

3 PDB 3D structures from and Proteopedia for RNASEL:

1WDY (3D)

4G8K (3D)

4G8L (3D)

Secondary accessions: Q5W0L2

Explore the universe of human proteins at neXtProt for RNASEL: NX_Q05823

Explore proteomics data for RNASEL at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See RNASEL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_066956.1

ENSEMBL proteins:

ENSP00000356530 ENSP00000411147 ENSP00000440844

Reactome Protein details: Q05823

RNASEL Human Recombinant Protein Products:

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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for RNASEL
	GenScript Custom Purified and Recombinant Proteins Services for RNASEL
	Novus Biologicals RNASEL Protein
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RNASEL

RNASEL Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RNASEL
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	OriGene Antibodies for RNASEL OriGene Custom Antibody Services for RNASEL
	Novus Biologicals RNASEL Antibodies
	Abcam antibodies for RNASEL
	Cloud-Clone Corp. Antibodies for RNASEL
	ThermoFisher Antibodies for RNASEL
	LSBio Antibodies in human, mouse, rat for RNASEL

RNASEL Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RNASEL
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RNASEL Cloud-Clone Corp. CLIAs for RNASEL

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ANKRD: Ankyrin repeat domain containing

Selected InterPro protein domains (see all 6):

IPR000719 Prot_kinase_dom

IPR020683 Ankyrin_rpt-contain_dom

IPR010513 KEN_dom

IPR006567 PUG-dom

IPR002110 Ankyrin_rpt

Graphical View of Domain Structure for InterPro Entry Q05823

ProtoNet protein and cluster: Q05823

2 Blocks protein domains:

IPB006567 PUG

IPB010513 Ribonuclease 2-5A

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

Domain: The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain

Domain: The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization

Domain: The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is

sufficient for ribonuclease activity (By similarity)

Similarity: Belongs to the protein kinase superfamily

Similarity: Contains 9 ANK repeats

Similarity: Contains 1 KEN domain

Similarity: Contains 1 protein kinase domain

RNASEL for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: RN5A_HUMAN, Q05823

Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus

infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of

single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of

apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent

stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.

Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might

play a central role in the regulation of mRNA turnover

Catalytic activity: Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete

products ranging from between 4 and 22 nucleotides in length

Enzyme regulation: After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and

subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding

cassette (ABC) transporter family

Induction: By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to

transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases (OASs). oligoadenylate

synthetase is stimulated by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose

function is to activate RNASEL

Genatlas biochemistry entry for RNASEL:

ribonuclease L,2',5'-oligoisoadenylate dependent,interferon regulated pathway

Enzyme Number (IUBMB): EC 3.1.26.-¹

Gene Ontology (GO): Selected molecular function terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	IDA	7514601
GO:0004521	endoribonuclease activity	NAS	7514601
GO:0004540	ribonuclease activity	--	--
GO:0004672	protein kinase activity	IEA	--
GO:0005515	protein binding	IPI	--

RNASEL for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for RNASEL:

Decreased substrate adherent c

Increased cell death HMECs cel

Synthetic lethal with gemcitab

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rnasel):

cellular

hematopoietic system

immune system

RNASEL for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Rnasel^tm1Slvm for RNASEL

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNASEL

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNASEL

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASEL

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASEL

miRNA Products:		miRTarBase miRNAs that target RNASEL: hsa-mir-335-5p (MIRT019056), hsa-mir-16-5p (MIRT000901), hsa-mir-215-5p (MIRT024876), hsa-mir-15a-5p (MIRT000902), hsa-mir-192-5p (MIRT026865)

		Block miRNA regulation of human, mouse, rat RNASEL using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate RNASEL (see all 10):
		hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b

		SwitchGear 3'UTR luciferase reporter plasmid: RNASEL 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RNASEL
		Predesigned siRNA for gene silencing in human, mouse, rat RNASEL

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RNASEL

Clone Products:		OriGene clones in human, mouse for RNASEL (see all 7) OriGene ORF clones in mouse, rat for RNASEL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RNASEL (NM_021133)
		Sino Biological Human cDNA Clone for RNASEL
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASEL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RNASEL
		Browse ESI BIO Cell Lines and PureStem Progenitors for RNASEL

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

RN5A_HUMAN, Q05823: Cytoplasm. Mitochondrion

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	5
cytosol	4
nucleus	2
endoplasmic reticulum	1
extracellular	1
plasma membrane	1

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--
GO:0016020	membrane	--	--
GO:0016363	nuclear matrix	IEA	--

RNASEL for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RNASEL About

See pathways by source

SuperPath

Contained pathways About

Interferon Signaling

Interferon Signaling

0.59

Cytokine Signaling in Immune system

0.59

Influenza A

Influenza A

0.34

Herpes simplex infection

0.33

Immune response IFN alpha beta signaling pathway

Interferon alpha/beta signaling

0.43

Senescence and Autophagy

Senescence and Autophagy

Hepatitis C

Hepatitis C

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for RNASEL

Senescence and Autophagy

1 Reactome Pathway for RNASEL

Interferon alpha/beta signaling

3 Kegg Pathways (Kegg details for RNASEL):

	Hepatitis C
	Influenza A
	Herpes simplex infection

RNASEL for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including RNASEL:

Polycomb & Trithorax Complexes in human mouse rat

Interactions:

GeneGlobe Interaction Network for RNASEL

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RNASEL (Q05823^{1, 2, 3} ENSP00000356530⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 121)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IQGAP1	P46940¹^,²^,³, ENSP00000268182⁴	EBI-8390477,EBI-297509 MINT-7990598 MINT-7990574 I2D: score=1 STRING: ENSP00000268182
AR	P10275³, ENSP00000363822⁴	I2D: score=1 STRING: ENSP00000363822
ABCE1	P61221³, ENSP00000296577⁴	I2D: score=2 STRING: ENSP00000296577
KIF23	Q02241², ENSP00000260363⁴	MINT-7990574 STRING: ENSP00000260363
GSPT1	P15170³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006364	rRNA processing	IEA	--
GO:0006397	mRNA processing	IEA	--
GO:0006468	protein phosphorylation	NAS	7514601
GO:0009103	lipopolysaccharide biosynthetic process	--	--
GO:0019221	cytokine-mediated signaling pathway	TAS	--

RNASEL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for RNASEL (RN5A)

2 HMDB Compounds for RNASEL About this table

Compound	Synonyms	CAS #	PubMed Ids
Magnesium	Magnesium (see all 2)	7439-95-4	--
Manganese	manganese	7439-96-5	--

Selected Novoseek inferred chemical compound relationships for RNASEL gene (see all 23) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2',5'-oligoadenylate	96.3	177	11152576 (6), 15924878 (6), 11323422 (5), 20022497 (5) (see all 71)
8-methyladenosine	89.9	8	19749291 (3), 20022497 (3), 12757397 (1)
ecyd	87	43	18668243 (3), 18029773 (2), 12903334 (2), 17150838 (2) (see all 6)
ampligen	76.7	10	7893988 (5), 8148461 (2), 8099601 (1), 15357629 (1)
oligoribonucleotide	61.3	5	8617774 (2), 14604670 (1), 10726660 (1), 10474231 (1)
phosphorothioate	45.1	5	7685081 (2), 7890727 (2), 14583476 (1)
rrna	42.3	19	8017832 (2), 11152576 (2), 12903195 (2), 12903334 (2) (see all 7)
oligonucleotide	40.4	10	7679499 (2), 18950583 (1), 11878909 (1), 9111293 (1) (see all 8)
atp	32.9	9	15013441 (1), 9862963 (1), 15383904 (1), 18160405 (1) (see all 7)
ifn-alpha	27.5	11	17431428 (3), 11585831 (2)

RNASEL for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RNASEL gene:

NM_021133.3

Unigene Cluster for RNASEL:

Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

Hs.518545 [show with all ESTs]

Unigene Representative Sequence: NM_021133

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000367559(uc009wxz.2) ENST00000444138 ENST00000539397(uc009wya.1 uc001gpk.3)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat RNASEL using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate RNASEL (see all 10):
		hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b

		SwitchGear 3'UTR luciferase reporter plasmid: RNASEL 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RNASEL
		Predesigned siRNA for gene silencing in human, mouse, rat RNASEL

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		GenScript: all cDNA clones in your preferred vector: RNASEL (NM_021133)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASEL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEL

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for RNASEL
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RNASEL
		QuantiTect SYBR Green Assays in human, mouse, rat RNASEL
		QuantiFast Probe-based Assays in human, mouse, rat RNASEL

Additional mRNA sequence:

AK315231.1 BC114433.1 BC115697.1 DQ352452.1

4 DOTS entries:

DT.211589 DT.86837487 DT.92002335 DT.425435

Selected AceView cDNA sequences (see all 57):

C01514 CR627369 BQ216121 AW016315 NM_021133 BX280477 CA447181 BE349148

CA439592 BQ030219 BX097443 BP335764 CF527913 BE778138 AI669749 AW138018

BU940316 W92226 BQ948773 BG427155 AW968304 BP336508 AA377605 AA258106

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNASEL expression in normal human tissues (normalized intensities) RNASEL embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCAATTAAAA

About this image

RNASEL expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 10) fully expand


Brain (Nervous System) fully expand to see all 5 entries
Adult Dopaminergic Neurons Ventral Tegmental Area
Cerebral Cortex

Blood (Cardiovascular System) fully expand to see all 2 entries
Granulocytes Peripheral Blood

Skeletal Muscle (Muscoskeletal System) fully expand to see all 2 entries
Myoblasts Mandibular Arch Muscles

Bone (Muscoskeletal System)
Bone Marrow

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

RNASEL Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RNASEL Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.518545

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine,

colon and peripheral blood leukocytes

Pathway & Disease-focused RT² Profiler PCR Array including RNASEL:

Polycomb & Trithorax Complexes in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for RNASEL
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RNASEL
		QuantiTect SYBR Green Assays in human, mouse, rat RNASEL
		QuantiFast Probe-based Assays in human, mouse, rat RNASEL

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RNASEL gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnasel^{1 , 5}	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)^{1, 5}	72.93(n)¹ 64.71(a)¹		1 (65.43 cM)⁵ 24014¹ NM_011882.2¹ NP_036012.1¹ 153749504⁵
chicken (Gallus gallus)	Aves	RNASEL¹	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	55(n) 43.99(a)		424410 NM_001031267.1 NP_001026438.1
lizard (Anolis carolinensis)	Reptilia	RNASEL⁶	ribonuclease L (2',5'-oligoisoadenylate synthetase...	44(a)	1 ↔ 1	GL343683.1(13053-33071)

ENSEMBL Gene Tree for RNASEL (if available)
TreeFam Gene Tree for RNASEL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RNASEL gene

1 SIMAP similar gene for RNASEL using alignment to 2 protein entries: RN5A_HUMAN (see all proteins):

DKFZp781D08126

RNASEL for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74315364^1,2	C,F	pathogenic¹	189107374(-)	`ACATAG/TAGATT`	2	E *	stg¹		2		NA EU	5873
rs74315365^1,2	C	pathogenic¹	189108164(-)	`GTCATA/GGAGAG`	2	I M	mis¹		0	--	--	--	--
rs486907^1,2,,4	C,F,O,A,H	other¹	189106782(-)	`TGCCCG/AAAATG`	2	/Q /R	mis¹ ese³		34		MN NS EA NA WA CSA EU	9296
rs73061339^1,2	C,F	--	182553014(+)	`ACCCAT/CCACTG`	1	--	int¹		3		WA CSA	121
rs589402^1,2	C,F,A,H	--	189094536(+)	`CACCAT/AGTGAG`	1	--	ds500¹		21		MN NS EA NA WA CSA	1704
rs112325086^1,2	C	--	189094556(+)	`TATGAA/TCTCTG`	1	--	ds500¹		2		CSA	3
rs188223507^1,2		--	189094585(+)	`AGAGAC/GAGGTA`	1	--	ds500¹		0	--	--	--	--
rs151012620^1,2	C	--	189094607(+)	`CTGCTA/GAGTAA`	1	--	ds500¹		0	--	--	--	--
rs193258729^1,2		--	189094658(+)	`AGAATC/TAGCCT`	1	--	ds500¹		0	--	--	--	--
rs73061324^1,2	C,F	--	189094705(+)	`TGAAAT/AGTTTG`	1	--	ds500¹		3		WA	122

HapMap Linkage Disequilibrium report for RNASEL (182542769 - 182558394 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RNASEL: About this table

Variant ID	Type	Subtype	PubMed ID
esv1010175	CNV	Deletion	20482838
nsv825531	CNV	Loss	20364138
nsv825564	CNV	Loss	20364138

Human Gene Mutation Database (HGMD): RNASEL

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RNASEL

DNA2.0 Custom Variant and Variant Library Synthesis for RNASEL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 180435
OMIM disorders: 601518
UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823

Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition

to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic

ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include

small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell

carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and

neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene

represented in this entry

Selected diseases for RNASEL (see all 53): About MalaCards

chronic fatigue syndrome prostate cancer 1 parainfluenza virus type 3 prostate cancer, progression and metastasis of

myelitis prostate cancer lynch syndrome prostatitis

west nile virus hairy cell leukemia hepatitis a vaccinia

dengue hemorrhagic fever fibrosarcoma herpes simplex malignant glioma

neuroendocrine carcinoma adenoiditis hemorrhagic fever hepatitis c

2 diseases from the University of Copenhagen DISEASES database for RNASEL:

Chronic fatigue syndrome Prostate cancer

RNASEL for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for RNASEL gene (see all 27) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer, hereditary, 1	93.8	11	12590567 (1), 11799394 (1), 15604285 (1), 16241858 (1) (see all 8)
chronic fatigue syndrome	71.5	16	7893988 (2), 8148461 (2), 15924878 (2), 16277015 (2) (see all 11)
prostate cancer	65.7	125	12590567 (6), 20086112 (6), 16537704 (6), 18189233 (5) (see all 49)
virus infection	57.6	20	18029773 (2), 7679499 (2), 1374726 (1), 16235172 (1) (see all 13)
parainfluenza	43.1	2	9858317 (1), 17535916 (1)
fibrosarcoma	33.9	2	17055253 (2)
vesicular stomatitis	29.5	1	9858317 (1)
malignant glioma	22.7	1	11586885 (1)
cancer	22.7	13	16241858 (2), 18575592 (2), 15330212 (1), 15040862 (1) (see all 8)
immunodeficiency	17.6	7	9847332 (2), 7890727 (1), 18160405 (1)

Genetic Association Database (GAD): RNASEL
Human Genome Epidemiology (HuGE) Navigator: RNASEL (45 documents)

Export disorders for RNASEL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RNASEL gene, integrated from 10 sources (see all 302):
(articles sorted by number of sources associating them with RNASEL)

Utopia: connect your pdf to the dynamic
world of online information

Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. (PubMed id 11941539)^{1, 2, 4, 9} Roekman A.... Schleutker J. (Am. J. Hum. Genet. 2002)
The 2-5A system in viral infection and apoptosis. (PubMed id 9856285)^{1, 2, 9} Castelli J.... Youle R.J. (Biomed. Pharmacother. 1998)
Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer. (PubMed id 18575592)^{1, 4, 9} Madsen B.E....Hansen L.L. (PLoS ONE 2008)
Alternative function of a protein kinase homology domain in 2', 5'- oligoadenylate dependent RNase L. (PubMed id 9862963)^{1, 2, 9} Dong B. and Silverman R.H. (Nucleic Acids Res. 1999)
Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. (PubMed id 20086112)^{1, 4, 9} Beuten J....Leach R.J. (amp 2010)
Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene. (PubMed id 15714208)^{1, 4, 9} Maier C....Paiss T. (Br. J. Cancer 2005)
Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases. (PubMed id 18767027)^{1, 4, 9} Robbins C.M....Kittles R.A. (Prostate 2008)
RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans. (PubMed id 18189233)^{1, 4, 9} Shea P.R....Ferrell R.E. (Prostate 2008)
RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients. (PubMed id 16537704)^{1, 4, 9} Orr-Urtreger A....Matzkin H. (amp 2006)
Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. (PubMed id 11799394)^{1, 2, 9} Carpten J.... Trent J. (Nat. Genet. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6041	HGNC: 10050	AceView: RNASEL	Ensembl:ENSG00000135828	euGenes: HUgn6041
ECgene: RNASEL	Kegg: 6041	H-InvDB: RNASEL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RNASEL	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RNASEL	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RNASEL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RNASEL gene:
Search GeneIP for patents involving RNASEL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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RNASEL Gene

Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)

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PROSTATE CANCER, HEREDITARY, 1
Chronic Fatigue Syndrome
HERPES
Ovarian Cancer
HIV Infections
benign prostatic hyperplasia
Herpes Simplex
Inflammation
Dengue
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Myeloid Leukemia Chronic
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Vesicular stomatitis
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RNASEL Gene

Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)

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