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RNASEL Gene

protein-coding   GIFtS: 66
GCID: GC01M182542

Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)

(Previous name: prostate cancer 1)
(Previous symbols: RNS4, PRCA1)
  See RNASEL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent)1 2     2',5'-Oligoisoadenylate Synthetase-Dependent2
RNS41 2 3 5     2-5A-Dependent Ribonuclease2
PRCA11 2 5     Interferon-Induced 2-5A-Dependent RNase2
Ribonuclease 42 3     EC 3.1.26.-3
2-5A-Dependent RNase2 3     Ribonuclease L3
RNase L2 3     HPC15
Prostate Cancer 11     

External Ids:    HGNC: 100501   Entrez Gene: 60412   Ensembl: ENSG000001358287   OMIM: 1804355   UniProtKB: Q058233   

Export aliases for RNASEL gene to outside databases

Previous GC identifers: GC01M180070 GC01M177972 GC01M179063 GC01M179782 GC01M179274 GC01M180809 GC01M153780


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNASEL Gene:
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and
antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to
prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RNASEL Gene:
RNASEL (ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)) is a protein-coding gene. Diseases associated with RNASEL include prostate cancer 1, and chronic fatigue syndrome. GO annotations related to this gene include endoribonuclease activity and RNA binding.

UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus
infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of
single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of
apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent
stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.
Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might
play a central role in the regulation of mRNA turnover

Gene Wiki entry for RNASEL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASEL gene promoter:
         AhR   ER-alpha   GATA-3   AP-1   ATF-2   AP-4   Arnt   HNF-4alpha1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASEL promoter sequence
   Search Chromatin IP Primers for RNASEL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASEL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25   Ensembl cytogenetic band:  1q25.3   HGNC cytogenetic band: 1q25

RNASEL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M182542:  view genomic region     (about GC identifiers)

Start:
182,542,769 bp from pter      End:
182,558,394 bp from pter
Size:
15,626 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823 (See protein sequence)
Recommended Name: 2-5A-dependent ribonuclease  
Size: 741 amino acids; 83533 Da
Cofactor: Manganese or magnesium. Required for optimal RNA cleavage rates
Subunit: Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL
3 PDB 3D structures from and Proteopedia for RNASEL:
1WDY (3D)        4G8K (3D)        4G8L (3D)    
Secondary accessions: Q5W0L2

Explore the universe of human proteins at neXtProt for RNASEL: NX_Q05823

Explore proteomics data for RNASEL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNASEL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066956.1  
    ENSEMBL proteins: 
     ENSP00000356530   ENSP00000411147   ENSP00000440844  
    Reactome Protein details: Q05823

    RNASEL Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals RNASEL Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNASEL

     
    Search eBioscience for Proteins for RNASEL 

    RNASEL Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RNASEL
    Browse R&D Systems for Antibodies
    OriGene Antibodies for RNASEL
    OriGene Custom Antibody Services for RNASEL
    Novus Biologicals RNASEL Antibodies
    Abcam antibodies for RNASEL
    Cloud-Clone Corp. Antibodies for RNASEL
    ThermoFisher Antibodies for RNASEL
    LSBio Antibodies in human, mouse, rat for RNASEL

    RNASEL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNASEL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNASEL
    Cloud-Clone Corp. CLIAs for RNASEL
    Search eBioscience for ELISAs for RNASEL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR000719 Prot_kinase_dom
     IPR020683 Ankyrin_rpt-contain_dom
     IPR010513 KEN_dom
     IPR006567 PUG-dom
     IPR002110 Ankyrin_rpt

    Graphical View of Domain Structure for InterPro Entry Q05823

    ProtoNet protein and cluster: Q05823

    2 Blocks protein domains:
    IPB006567 PUG
    IPB010513 Ribonuclease 2-5A


    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
    Domain: The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain
    Domain: The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization
    Domain: The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is
    sufficient for ribonuclease activity (By similarity)
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 9 ANK repeats
    Similarity: Contains 1 KEN domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with RNASEL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RN5A_HUMAN, Q05823
    Function: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus
    infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of
    single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of
    apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent
    stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis.
    Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might
    play a central role in the regulation of mRNA turnover
    Catalytic activity: Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete
    products ranging from between 4 and 22 nucleotides in length
    Enzyme regulation: After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and
    subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding
    cassette (ABC) transporter family
    Induction: By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to
    transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases (OASs). oligoadenylate
    synthetase is stimulated by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose
    function is to activate RNASEL

         Genatlas biochemistry entry for RNASEL:
    ribonuclease L,2',5'-oligoisoadenylate dependent,interferon regulated pathway

         Enzyme Number (IUBMB): EC 3.1.26.-1

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA7514601
    GO:0004521endoribonuclease activity NAS7514601
    GO:0004540ribonuclease activity ----
    GO:0004672protein kinase activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with RNASEL           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RNASEL:
     Decreased substrate adherent c  Increased cell death HMECs cel  Synthetic lethal with gemcitab 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rnasel):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with RNASEL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rnaseltm1Slvm for RNASEL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNASEL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNASEL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASEL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASEL

    miRNA
    Products:
        
    miRTarBase miRNAs that target RNASEL:
    hsa-mir-335-5p (MIRT019056), hsa-mir-16-5p (MIRT000901), hsa-mir-215-5p (MIRT024876), hsa-mir-15a-5p (MIRT000902), hsa-mir-192-5p (MIRT026865)

    Block miRNA regulation of human, mouse, rat RNASEL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNASEL (see all 10):
    hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidRNASEL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNASEL
    Predesigned siRNA for gene silencing in human, mouse, rat RNASEL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RNASEL

    Clone
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    OriGene clones in human, mouse for RNASEL (see all 7)
    OriGene ORF clones in mouse, rat for RNASEL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASEL (NM_021133)
    Sino Biological Human cDNA Clone for RNASEL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASEL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEL

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RNASEL
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNASEL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RN5A_HUMAN, Q05823: Cytoplasm. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol4
    nucleus2
    endoplasmic reticulum1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0016020membrane ----
    GO:0016363nuclear matrix IEA--

    Find genes that share ontologies with RNASEL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNASEL About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    2Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    3Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43
    4Senescence and Autophagy
    Senescence and Autophagy
    5Hepatitis C
    Hepatitis C


    Find genes that share SuperPaths with RNASEL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RNASEL
        Senescence and Autophagy


    1 Reactome Pathway for RNASEL
        Interferon alpha/beta signaling


    3 Kegg Pathways  (Kegg details for RNASEL):
        Hepatitis C
    Influenza A
    Herpes simplex infection

        Pathway & Disease-focused RT2 Profiler PCR Array including RNASEL: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNASEL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNASEL (Q058231, 2, 3 ENSP000003565304) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IQGAP1P469401, 2, 3, ENSP000002681824EBI-8390477,EBI-297509 MINT-7990598 MINT-7990574 I2D: score=1 STRING: ENSP00000268182
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    ABCE1P612213, ENSP000002965774I2D: score=2 STRING: ENSP00000296577
    KIF23Q022412, ENSP000002603634MINT-7990574 STRING: ENSP00000260363
    GSPT1P151703I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006364rRNA processing IEA--
    GO:0006397mRNA processing IEA--
    GO:0006468protein phosphorylation NAS7514601
    GO:0009103lipopolysaccharide biosynthetic process ----
    GO:0019221cytokine-mediated signaling pathway TAS--

    Find genes that share ontologies with RNASEL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASEL (RN5A)

    2 HMDB Compounds for RNASEL    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    Selected Novoseek inferred chemical compound relationships for RNASEL gene (see all 23)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 96.3 177 11152576 (6), 15924878 (6), 11323422 (5), 20022497 (5) (see all 71)
    8-methyladenosine 89.9 8 19749291 (3), 20022497 (3), 12757397 (1)
    ecyd 87 43 18668243 (3), 18029773 (2), 12903334 (2), 17150838 (2) (see all 6)
    ampligen 76.7 10 7893988 (5), 8148461 (2), 8099601 (1), 15357629 (1)
    oligoribonucleotide 61.3 5 8617774 (2), 14604670 (1), 10726660 (1), 10474231 (1)
    phosphorothioate 45.1 5 7685081 (2), 7890727 (2), 14583476 (1)
    rrna 42.3 19 8017832 (2), 11152576 (2), 12903195 (2), 12903334 (2) (see all 7)
    oligonucleotide 40.4 10 7679499 (2), 18950583 (1), 11878909 (1), 9111293 (1) (see all 8)
    atp 32.9 9 15013441 (1), 9862963 (1), 15383904 (1), 18160405 (1) (see all 7)
    ifn-alpha 27.5 11 17431428 (3), 11585831 (2)



    Find genes that share compounds with RNASEL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNASEL gene: 
    NM_021133.3  

    Unigene Cluster for RNASEL:

    Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
    Hs.518545  [show with all ESTs]
    Unigene Representative Sequence: NM_021133
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367559(uc009wxz.2) ENST00000444138 ENST00000539397(uc009wya.1 uc001gpk.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNASEL (see all 10):
    hsa-miR-21* hsa-miR-3140-3p hsa-miR-520d-5p hsa-miR-3688-3p hsa-miR-146a hsa-miR-548aa hsa-miR-3921 hsa-miR-513b
    SwitchGear 3'UTR luciferase reporter plasmidRNASEL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNASEL
    Clone
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    GenScript: all cDNA clones in your preferred vector: RNASEL (NM_021133)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASEL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RNASEL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASEL
      QuantiTect SYBR Green Assays in human, mouse, rat RNASEL
      QuantiFast Probe-based Assays in human, mouse, rat RNASEL

    Additional mRNA sequence: 

    AK315231.1 BC114433.1 BC115697.1 DQ352452.1 

    4 DOTS entries:

    DT.211589  DT.86837487  DT.92002335  DT.425435 

    Selected AceView cDNA sequences (see all 57):

    C01514 CR627369 BQ216121 AW016315 NM_021133 BX280477 CA447181 BE349148 
    CA439592 BQ030219 BX097443 BP335764 CF527913 BE778138 AI669749 AW138018 
    BU940316 W92226 BQ948773 BG427155 AW968304 BP336508 AA377605 AA258106 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASEL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATTAAAA
    RNASEL Expression
    About this image


    RNASEL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Cerebral Cortex
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    RNASEL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASEL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518545

    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
    Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine,
    colon and peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including RNASEL: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASEL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASEL
    QuantiTect SYBR Green Assays in human, mouse, rat RNASEL
    QuantiFast Probe-based Assays in human, mouse, rat RNASEL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNASEL gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnasel1 , 5 ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)1, 5 72.93(n)1
    64.71(a)1
      1 (65.43 cM)5
    240141  NM_011882.21  NP_036012.11 
     1537495045 
    chicken
    (Gallus gallus)
    Aves RNASEL1 ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 55(n)
    43.99(a)
      424410  NM_001031267.1  NP_001026438.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNASEL6
    ribonuclease L (2',5'-oligoisoadenylate synthetase...
    44(a)
    1 ↔ 1
    GL343683.1(13053-33071)


    ENSEMBL Gene Tree for RNASEL (if available)
    TreeFam Gene Tree for RNASEL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNASEL gene
    1 SIMAP similar gene for RNASEL using alignment to 2 protein entries:     RN5A_HUMAN (see all proteins):
    DKFZp781D08126

    Find genes that share paralogs with RNASEL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNASEL (see all 439)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs743153641,2
    C,Fpathogenic1189107374(-) ACATAG/TAGATT 2 E * stg12Minor allele frequency- T:0.00NA EU 5873
    rs743153651,2
    Cpathogenic1189108164(-) GTCATA/GGAGAG 2 I M mis10--------
    rs4869071,2,,4
    C,F,O,A,Hother1189106782(-) TGCCCG/AAAATG 2 /Q /R mis1 ese334Minor allele frequency- A:0.28MN NS EA NA WA CSA EU 9296
    rs730613391,2
    C,F--182553014(+) ACCCAT/CCACTG 1 -- int13Minor allele frequency- C:0.12WA CSA 121
    rs5894021,2
    C,F,A,H--189094536(+) CACCAT/AGTGAG 1 -- ds500121Minor allele frequency- A:0.06MN NS EA NA WA CSA 1704
    rs1123250861,2
    C--189094556(+) TATGAA/TCTCTG 1 -- ds50012Minor allele frequency- T:0.33CSA 3
    rs1882235071,2
    --189094585(+) AGAGAC/GAGGTA 1 -- ds50010--------
    rs1510126201,2
    C--189094607(+) CTGCTA/GAGTAA 1 -- ds50010--------
    rs1932587291,2
    --189094658(+) AGAATC/TAGCCT 1 -- ds50010--------
    rs730613241,2
    C,F--189094705(+) TGAAAT/AGTTTG 1 -- ds50013Minor allele frequency- A:0.05WA 122

    HapMap Linkage Disequilibrium report for RNASEL (182542769 - 182558394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNASEL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010175CNV Deletion20482838
    nsv825531CNV Loss20364138
    nsv825564CNV Loss20364138

    Human Gene Mutation Database (HGMD): RNASEL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASEL
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASEL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180435   
    OMIM disorders: 601518  
    UniProtKB/Swiss-Prot: RN5A_HUMAN, Q05823
  • Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition
    to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic
    ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include
    small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell
    carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and
    neuroendocrine carcinoma. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry

  • 6 diseases for RNASEL:    
    About MalaCards
    prostate cancer 1    chronic fatigue syndrome    parainfluenza virus type 3    prostate cancer, progression and metastasis of
    familial prostate cancer    prostate cancer

    2 diseases from the University of Copenhagen DISEASES database for RNASEL:
    Chronic fatigue syndrome     Prostate cancer

    Find genes that share disorders with RNASEL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RNASEL gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer, hereditary, 1 93.8 11 12590567 (1), 11799394 (1), 15604285 (1), 16241858 (1) (see all 8)
    chronic fatigue syndrome 71.5 16 7893988 (2), 8148461 (2), 15924878 (2), 16277015 (2) (see all 11)
    prostate cancer 65.7 125 12590567 (6), 20086112 (6), 16537704 (6), 18189233 (5) (see all 49)
    virus infection 57.6 20 18029773 (2), 7679499 (2), 1374726 (1), 16235172 (1) (see all 13)
    parainfluenza 43.1 2 9858317 (1), 17535916 (1)
    fibrosarcoma 33.9 2 17055253 (2)
    vesicular stomatitis 29.5 1 9858317 (1)
    malignant glioma 22.7 1 11586885 (1)
    cancer 22.7 13 16241858 (2), 18575592 (2), 15330212 (1), 15040862 (1) (see all 8)
    immunodeficiency 17.6 7 9847332 (2), 7890727 (1), 18160405 (1)

    Genetic Association Database (GAD): RNASEL
    Human Genome Epidemiology (HuGE) Navigator: RNASEL (45 documents)

    Export disorders for RNASEL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNASEL gene, integrated from 10 sources (see all 302):
    (articles sorted by number of sources associating them with RNASEL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. (PubMed id 11941539)1, 2, 4, 9 Roekman A.... Schleutker J. (Am. J. Hum. Genet. 2002)
    2. The 2-5A system in viral infection and apoptosis. (PubMed id 9856285)1, 2, 9 Castelli J.... Youle R.J. (Biomed. Pharmacother. 1998)
    3. Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer. (PubMed id 18575592)1, 4, 9 Madsen B.E....Hansen L.L. (PLoS ONE 2008)
    4. Alternative function of a protein kinase homology domain in 2', 5'- oligoadenylate dependent RNase L. (PubMed id 9862963)1, 2, 9 Dong B. and Silverman R.H. (Nucleic Acids Res. 1999)
    5. Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. (PubMed id 20086112)1, 4, 9 Beuten J....Leach R.J. (amp 2010)
    6. Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene. (PubMed id 15714208)1, 4, 9 Maier C....Paiss T. (Br. J. Cancer 2005)
    7. Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases. (PubMed id 18767027)1, 4, 9 Robbins C.M....Kittles R.A. (Prostate 2008)
    8. RNASEL and RNASEL-inhibitor variation and prostate cancer risk in Afro-Caribbeans. (PubMed id 18189233)1, 4, 9 Shea P.R....Ferrell R.E. (Prostate 2008)
    9. RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients. (PubMed id 16537704)1, 4, 9 Orr-Urtreger A....Matzkin H. (amp 2006)
    10. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. (PubMed id 11799394)1, 2, 9 Carpten J.... Trent J. (Nat. Genet. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6041 HGNC: 10050 AceView: RNASEL Ensembl:ENSG00000135828 euGenes: HUgn6041
    ECgene: RNASEL Kegg: 6041 H-InvDB: RNASEL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNASEL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RNASEL Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNASEL gene:
    Search GeneIP for patents involving RNASEL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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