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Aliases for RNASEK-C17orf49 Gene

Subcategory (RNA class) for RNASEK-C17orf49 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for RNASEK-C17orf49 Gene

  • RNASEK-C17orf49 Readthrough 2 3 5
  • RNASEK-C17orf49 Readthrough (Non-Protein Coding) 2

External Ids for RNASEK-C17orf49 Gene

Previous GeneCards Identifiers for RNASEK-C17orf49 Gene

  • GC17P006916
  • GC17P006919

Summaries for RNASEK-C17orf49 Gene

Entrez Gene Summary for RNASEK-C17orf49 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring RNASEK (ribonuclease, RNase K) and C17orf49 (chromosome 17 open reading frame 49) genes. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is unlikely to produce a protein product. [provided by RefSeq, Jan 2011]

GeneCards Summary for RNASEK-C17orf49 Gene

RNASEK-C17orf49 (RNASEK-C17orf49 Readthrough) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include chromatin binding. An important paralog of this gene is C17orf49.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASEK-C17orf49 Gene

Genomics for RNASEK-C17orf49 Gene

Regulatory Elements for RNASEK-C17orf49 Gene

Enhancers for RNASEK-C17orf49 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G006913 1 Ensembl ENCODE 12.7 -98.3 -98276 0.9 CTCF RB1 RAD21 ZNF664 POLR2A ZNF143 SMC3 CREM EZH2 STAT1 ALOX12 ALOX12-AS1 RNASEK RNASEK-C17orf49 MIR195 BCL6B SLC16A11 MED31 C17orf100 SLC13A5
GH17G006843 0.7 ENCODE 11.9 -169.0 -168961 0.2 CTCF ZFP64 RAD21 ZNF697 SMC3 RFX1 ZNF654 ZBTB11 ZNF426 REST NLGN2 DVL2 ALOX12 ALOX12-AS1 RNASEK-C17orf49 RNASEK MIR497HG SLC13A5 C17orf100 MED31
GH17G006919 0.7 FANTOM5 11.4 -92.7 -92664 0.4 HDAC1 PKNOX1 TFAP4 ZNF175 CEBPG GABPA POLR2H ZNF589 SMARCA4 TARDBP ALOX12 RNASEK RNASEK-C17orf49 ALOX12-AS1 BCL6B SLC13A5 MIR195 SLC16A11 GC17M006933 GC17P006901
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASEK-C17orf49 on UCSC Golden Path with GeneCards custom track

Promoters for RNASEK-C17orf49 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090784 983 4401 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21

Genomic Location for RNASEK-C17orf49 Gene

Chromosome:
17
Start:
7,012,417 bp from pter
End:
7,017,524 bp from pter
Size:
5,108 bases
Orientation:
Plus strand

Genomic View for RNASEK-C17orf49 Gene

Genes around RNASEK-C17orf49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASEK-C17orf49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASEK-C17orf49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASEK-C17orf49 Gene

Proteins for RNASEK-C17orf49 Gene

  • Protein details for RNASEK-C17orf49 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YIS7
    Recommended name:
    RNASEK-C17orf49 readthrough
    Protein Accession:
    H0YIS7

    Protein attributes for RNASEK-C17orf49 Gene

    Size:
    233 amino acids
    Molecular mass:
    24879 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASEK-C17orf49 Gene

Protein Expression for RNASEK-C17orf49 Gene

Post-translational modifications for RNASEK-C17orf49 Gene

No Post-translational modifications

Other Protein References for RNASEK-C17orf49 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for RNASEK-C17orf49 Gene

Domains & Families for RNASEK-C17orf49 Gene

Protein Domains for RNASEK-C17orf49 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNASEK-C17orf49: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNASEK-C17orf49 Gene

Function for RNASEK-C17orf49 Gene

Phenotypes for RNASEK-C17orf49 Gene

GenomeRNAi human phenotypes for RNASEK-C17orf49:
genes like me logo Genes that share phenotypes with RNASEK-C17orf49: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASEK-C17orf49 Gene

Localization for RNASEK-C17orf49 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASEK-C17orf49 gene
Compartment Confidence
nucleus 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RNASEK-C17orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016589 NURF complex IBA --
genes like me logo Genes that share ontologies with RNASEK-C17orf49: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNASEK-C17orf49 Gene

Pathways & Interactions for RNASEK-C17orf49 Gene

SuperPathways for RNASEK-C17orf49 Gene

No Data Available

Interacting Proteins for RNASEK-C17orf49 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000450085%0d%0a9606.ENSP00000307208%0d%0a
Selected Interacting proteins: ENSP00000450085 for RNASEK-C17orf49 Gene via STRING

Symbol External ID(s) Details
BPTF

Gene Ontology (GO) - Biological Process for RNASEK-C17orf49 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNASEK-C17orf49 Gene

Drugs & Compounds for RNASEK-C17orf49 Gene

No Compound Related Data Available

Transcripts for RNASEK-C17orf49 Gene

mRNA/cDNA for RNASEK-C17orf49 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNASEK-C17orf49 Gene

No ASD Table

Relevant External Links for RNASEK-C17orf49 Gene

GeneLoc Exon Structure for
RNASEK-C17orf49
ECgene alternative splicing isoforms for
RNASEK-C17orf49

Expression for RNASEK-C17orf49 Gene

Protein differential expression in normal tissues from HIPED for RNASEK-C17orf49 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for RNASEK-C17orf49 Gene



Protein tissue co-expression partners for RNASEK-C17orf49 Gene

Evidence on tissue expression from TISSUES for RNASEK-C17orf49 Gene

  • Adrenal gland(2.6)
  • Bone marrow(2.6)
  • Gall bladder(2.6)
  • Intestine(2.6)
  • Kidney(2.6)
  • Liver(2.6)
  • Lung(2.6)
  • Lymph node(2.6)
  • Pancreas(2.6)
  • Skin(2.6)
  • Spleen(2.6)
  • Thyroid gland(2.6)
  • Nervous system(2.6)
  • Muscle(2.2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASEK-C17orf49 Gene

Orthologs for RNASEK-C17orf49 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNASEK-C17orf49 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BAP18 35
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 0610010K14Rik 35
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:103508 35
  • 66 (a)
ManyToMany
zgc:92664 35
  • 63 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG33695 35
  • 22 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y43F8C.6 35
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3343 35
  • 31 (a)
OneToMany
Species where no ortholog for RNASEK-C17orf49 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNASEK-C17orf49 Gene

ENSEMBL:
Gene Tree for RNASEK-C17orf49 (if available)
TreeFam:
Gene Tree for RNASEK-C17orf49 (if available)

Paralogs for RNASEK-C17orf49 Gene

Paralogs for RNASEK-C17orf49 Gene

(3) SIMAP similar genes for RNASEK-C17orf49 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNASEK-C17orf49: view

Variants for RNASEK-C17orf49 Gene

Sequence variations from dbSNP and Humsavar for RNASEK-C17orf49 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000296550 -- 7,012,914(+) AATGG(A/G)AACTG intron-variant, upstream-variant-2KB
rs1001139790 -- 7,015,996(+) AGTTT(A/T)TTAGA intron-variant, nc-transcript-variant
rs1001337651 -- 7,017,410(+) TGAAA(A/G)GCTGC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1001397642 -- 7,017,139(+) GCTCT(C/T)ATACA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1001415260 -- 7,012,095(+) AAAAG(G/T)GGGTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASEK-C17orf49 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Relevant External Links for RNASEK-C17orf49 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASEK-C17orf49

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RNASEK-C17orf49 Gene

Disorders for RNASEK-C17orf49 Gene

Relevant External Links for RNASEK-C17orf49

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASEK-C17orf49

No disorders were found for RNASEK-C17orf49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASEK-C17orf49 Gene

Publications for RNASEK-C17orf49 Gene

  1. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for RNASEK-C17orf49 Gene

Sources for RNASEK-C17orf49 Gene

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