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Aliases for RNASEK Gene

Aliases for RNASEK Gene

  • Ribonuclease K 2 3 5
  • Ribonuclease, RNase K 2
  • RNase Kappa 4
  • EC 3.1.-.- 4
  • RNase K 4

External Ids for RNASEK Gene

Previous GeneCards Identifiers for RNASEK Gene

  • GC17P006862
  • GC17P006863
  • GC17P006915

Summaries for RNASEK Gene

GeneCards Summary for RNASEK Gene

RNASEK (Ribonuclease K) is a Protein Coding gene. GO annotations related to this gene include endoribonuclease activity.

UniProtKB/Swiss-Prot for RNASEK Gene

  • Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASEK Gene

Genomics for RNASEK Gene

Regulatory Elements for RNASEK Gene

Enhancers for RNASEK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RNASEK on UCSC Golden Path with GeneCards custom track

Promoters for RNASEK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNASEK on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASEK Gene

Chromosome:
17
Start:
7,012,417 bp from pter
End:
7,014,533 bp from pter
Size:
2,117 bases
Orientation:
Plus strand

Genomic View for RNASEK Gene

Genes around RNASEK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASEK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASEK Gene

Proteins for RNASEK Gene

  • Protein details for RNASEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5S7-RNK_HUMAN
    Recommended name:
    Ribonuclease kappa
    Protein Accession:
    Q6P5S7
    Secondary Accessions:
    • G3V1Z9
    • Q502Z2

    Protein attributes for RNASEK Gene

    Size:
    137 amino acids
    Molecular mass:
    15420 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH51802.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH62705.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF82619.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAN89245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNASEK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASEK Gene

Post-translational modifications for RNASEK Gene

  • Ubiquitination at Lys 132
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNASEK Gene

Domains & Families for RNASEK Gene

Protein Domains for RNASEK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASEK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P5S7

UniProtKB/Swiss-Prot:

RNK_HUMAN :
  • Belongs to the RNase K family.
Family:
  • Belongs to the RNase K family.
genes like me logo Genes that share domains with RNASEK: view

No data available for Gene Families for RNASEK Gene

Function for RNASEK Gene

Molecular function for RNASEK Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.

Enzyme Numbers (IUBMB) for RNASEK Gene

Gene Ontology (GO) - Molecular Function for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004521 endoribonuclease activity IDA 17881363
genes like me logo Genes that share ontologies with RNASEK: view
genes like me logo Genes that share phenotypes with RNASEK: view

Animal Models for RNASEK Gene

MGI Knock Outs for RNASEK:

Animal Model Products

  • Taconic Biosciences Mouse Models for RNASEK

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNASEK Gene

Localization for RNASEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASEK Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASEK Gene COMPARTMENTS Subcellular localization image for RNASEK gene
Compartment Confidence
endosome 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNASEK: view

Pathways & Interactions for RNASEK Gene

SuperPathways for RNASEK Gene

No Data Available

Interacting Proteins for RNASEK Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000449500%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000449500 for RNASEK Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009303 rRNA transcription IDA 17881363
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASEK: view

No data available for Pathways by source and SIGNOR curated interactions for RNASEK Gene

Drugs & Compounds for RNASEK Gene

No Compound Related Data Available

Transcripts for RNASEK Gene

Unigene Clusters for RNASEK Gene

Ribonuclease, RNase K:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASEK Gene

No ASD Table

Relevant External Links for RNASEK Gene

GeneLoc Exon Structure for
RNASEK
ECgene alternative splicing isoforms for
RNASEK

Expression for RNASEK Gene

mRNA expression in normal human tissues for RNASEK Gene

mRNA differential expression in normal tissues according to GTEx for RNASEK Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for RNASEK Gene

This gene is overexpressed in Retina (41.6) and Pancreas (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASEK Gene



Protein tissue co-expression partners for RNASEK Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASEK Gene:

RNASEK

SOURCE GeneReport for Unigene cluster for RNASEK Gene:

Hs.632232

mRNA Expression by UniProt/SwissProt for RNASEK Gene:

Q6P5S7-RNK_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with RNASEK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNASEK Gene

Orthologs for RNASEK Gene

This gene was present in the common ancestor of animals.

Orthologs for RNASEK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASEK 34
  • 95.58 (n)
  • 98.98 (a)
RNASEK 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNASEK 34
  • 94.22 (n)
  • 94.9 (a)
RNASEK 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnasek 34
  • 94.56 (n)
  • 100 (a)
Rnasek 16
Gm21988 35
  • 100 (a)
OneToMany
Rnasek 35
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RNASEK 34
  • 100 (n)
  • 100 (a)
RNASEK 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnasek 34
  • 94.22 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RNASEK 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNASEK 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493134 34
  • 78.57 (n)
  • 84.69 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534769 34
  • 69.76 (n)
  • 74.23 (a)
rnaseka 35
  • 68 (a)
OneToMany
rnasekb 35
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG40127 35
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3620 35
  • 39 (a)
OneToOne
Species where no ortholog for RNASEK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNASEK Gene

ENSEMBL:
Gene Tree for RNASEK (if available)
TreeFam:
Gene Tree for RNASEK (if available)

Paralogs for RNASEK Gene

(1) SIMAP similar genes for RNASEK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RNASEK: view

No data available for Paralogs for RNASEK Gene

Variants for RNASEK Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASEK Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Variation tolerance for RNASEK Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASEK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASEK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RNASEK Gene

Disorders for RNASEK Gene

Relevant External Links for RNASEK

Genetic Association Database (GAD)
RNASEK
Human Genome Epidemiology (HuGE) Navigator
RNASEK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASEK

No disorders were found for RNASEK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASEK Gene

Publications for RNASEK Gene

  1. Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase. (PMID: 17881363) Economopoulou M.-A. … Sideris D.C. (Nucleic Acids Res. 2007) 2 3 4 65
  2. RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus. (PMID: 26212330) Perreira J.M. … Brass A.L. (Cell Rep 2015) 2 3 65
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  4. Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression. (PMID: 26487785) Traurig M. … Bogardus C. (Diabetes 2016) 3 65
  5. A Subtle Alternative Splicing Event Gives Rise to a Widely Expressed Human RNase k Isoform. (PMID: 24797913) Karousis E.D. … Sideris D.C. (PLoS ONE 2014) 3 65

Products for RNASEK Gene

Sources for RNASEK Gene

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