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Aliases for RNASEK Gene

Aliases for RNASEK Gene

  • Ribonuclease K 2 3 5
  • Ribonuclease, RNase K 2
  • RNase Kappa 4
  • EC 3.1.-.- 4
  • RNase K 4

External Ids for RNASEK Gene

Previous GeneCards Identifiers for RNASEK Gene

  • GC17P006862
  • GC17P006863
  • GC17P006915

Summaries for RNASEK Gene

GeneCards Summary for RNASEK Gene

RNASEK (Ribonuclease K) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include endoribonuclease activity.

UniProtKB/Swiss-Prot for RNASEK Gene

  • Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.

Additional gene information for RNASEK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASEK Gene

Genomics for RNASEK Gene

GeneHancer (GH) Regulatory Elements for RNASEK Gene

Promoters and enhancers for RNASEK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I007010 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 561.4 +5.3 5297 13.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MIR497HG RNASEK BCL6B C17orf49 ENSG00000267047 MIR195 MIR497 DVL2 SNORD10 CNTROB
GH17I007854 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11 +844.5 844548 5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 CYB5D1 NAA38 ENSG00000280046 GC17P007860 TMEM88 SNORD10 DVL2 PFAS SNORA48 CTC1
GH17I006913 Enhancer 0.9 Ensembl ENCODE 12.7 -98.3 -98276 0.9 CTCF RB1 RAD21 CC2D1A POLR2A BRD9 ARID2 SMC3 ZNF143 CREM ALOX12 ALOX12-AS1 RNASEK RNASEK-C17orf49 MIR195 BCL6B SLC16A11 C17orf100 MED31 SLC13A5
GH17I007474 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.1 +468.2 468172 12.5 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC POLR2A ZBTB4 SLC35G6 DVL2 PFAS SNORD10 CTC1 WRAP53 SNORA48 CNTROB
GH17I006427 Enhancer 0.8 Ensembl ENCODE 11 -584.6 -584616 0.8 SMARCA5 CTCF PKNOX1 IRF2 CBFB NR2F1 IRF5 DPF2 BCL11A POLR2A RNASEK AIPL1 ENSG00000262818
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNASEK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNASEK gene promoter:

Genomic Locations for RNASEK Gene

Genomic Locations for RNASEK Gene
chr17:7,012,417-7,014,533
(GRCh38/hg38)
Size:
2,117 bases
Orientation:
Plus strand
chr17:6,915,736-6,917,852
(GRCh37/hg19)

Genomic View for RNASEK Gene

Genes around RNASEK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASEK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASEK Gene

Proteins for RNASEK Gene

  • Protein details for RNASEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5S7-RNK_HUMAN
    Recommended name:
    Ribonuclease kappa
    Protein Accession:
    Q6P5S7
    Secondary Accessions:
    • G3V1Z9
    • Q502Z2

    Protein attributes for RNASEK Gene

    Size:
    137 amino acids
    Molecular mass:
    15420 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH51802.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH62705.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF82619.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAN89245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNASEK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASEK Gene

Post-translational modifications for RNASEK Gene

No data available for DME Specific Peptides for RNASEK Gene

Domains & Families for RNASEK Gene

Gene Families for RNASEK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for RNASEK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASEK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P5S7

UniProtKB/Swiss-Prot:

RNK_HUMAN :
  • Belongs to the RNase K family.
Family:
  • Belongs to the RNase K family.
genes like me logo Genes that share domains with RNASEK: view

Function for RNASEK Gene

Molecular function for RNASEK Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.

Enzyme Numbers (IUBMB) for RNASEK Gene

Phenotypes From GWAS Catalog for RNASEK Gene

Gene Ontology (GO) - Molecular Function for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004519 endonuclease activity IEA --
GO:0004521 endoribonuclease activity IDA,IEA 17881363
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RNASEK: view
genes like me logo Genes that share phenotypes with RNASEK: view

Animal Models for RNASEK Gene

MGI Knock Outs for RNASEK:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNASEK Gene

Localization for RNASEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASEK Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASEK gene
Compartment Confidence
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNASEK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASEK Gene

Pathways & Interactions for RNASEK Gene

SuperPathways for RNASEK Gene

No Data Available

Interacting Proteins for RNASEK Gene

Gene Ontology (GO) - Biological Process for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASEK: view

No data available for Pathways by source and SIGNOR curated interactions for RNASEK Gene

Drugs & Compounds for RNASEK Gene

No Compound Related Data Available

Transcripts for RNASEK Gene

Unigene Clusters for RNASEK Gene

Ribonuclease, RNase K:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASEK Gene

No ASD Table

Relevant External Links for RNASEK Gene

GeneLoc Exon Structure for
RNASEK
ECgene alternative splicing isoforms for
RNASEK

Expression for RNASEK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASEK Gene

mRNA differential expression in normal tissues according to GTEx for RNASEK Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for RNASEK Gene

This gene is overexpressed in Retina (41.6) and Pancreas (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASEK Gene



Protein tissue co-expression partners for RNASEK Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASEK Gene:

RNASEK

SOURCE GeneReport for Unigene cluster for RNASEK Gene:

Hs.632232

mRNA Expression by UniProt/SwissProt for RNASEK Gene:

Q6P5S7-RNK_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RNASEK Gene

  • Nervous system(4.7)
  • Adrenal gland(4.4)
  • Pancreas(2.4)
  • Bone marrow(2)
  • Gall bladder(2)
  • Heart(2)
  • Kidney(2)
  • Lung(2)
  • Lymph node(2)
  • Muscle(2)
  • Spleen(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with RNASEK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASEK Gene

Orthologs for RNASEK Gene

This gene was present in the common ancestor of animals.

Orthologs for RNASEK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASEK 33 34
  • 100 (n)
mouse
(Mus musculus)
Mammalia Gm21988 34
  • 100 (a)
OneToMany
Rnasek 33 16 34
  • 94.56 (n)
cow
(Bos Taurus)
Mammalia RNASEK 33 34
  • 95.58 (n)
dog
(Canis familiaris)
Mammalia RNASEK 33 34
  • 94.22 (n)
rat
(Rattus norvegicus)
Mammalia Rnasek 33
  • 94.22 (n)
oppossum
(Monodelphis domestica)
Mammalia RNASEK 34
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNASEK 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493134 33
  • 78.57 (n)
zebrafish
(Danio rerio)
Actinopterygii rnasekb 34
  • 70 (a)
OneToMany
LOC100534769 33
  • 69.76 (n)
rnaseka 34
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG40127 34
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3620 34
  • 39 (a)
OneToOne
Species where no ortholog for RNASEK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNASEK Gene

ENSEMBL:
Gene Tree for RNASEK (if available)
TreeFam:
Gene Tree for RNASEK (if available)

Paralogs for RNASEK Gene

(1) SIMAP similar genes for RNASEK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RNASEK: view

No data available for Paralogs for RNASEK Gene

Variants for RNASEK Gene

Sequence variations from dbSNP and Humsavar for RNASEK Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000296550 -- 7,012,914(+) G/A intron_variant
rs1001415260 -- 7,012,095(+) G/T upstream_transcript_variant
rs1001518276 -- 7,011,476(+) T/C upstream_transcript_variant
rs1001930551 -- 7,013,152(+) G/A intron_variant
rs1003843299 -- 7,013,170(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNASEK Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Variation tolerance for RNASEK Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASEK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASEK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASEK Gene

Disorders for RNASEK Gene

Additional Disease Information for RNASEK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNASEK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASEK Gene

Publications for RNASEK Gene

  1. Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase. (PMID: 17881363) Economopoulou MA … Sideris DC (Nucleic acids research 2007) 2 3 4 58
  2. RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus. (PMID: 26212330) Perreira JM … Brass AL (Cell reports 2015) 2 3 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Analysis of SLC16A11 Variants in 12,811 American Indians: Genotype-Obesity Interaction for Type 2 Diabetes and an Association With RNASEK Expression. (PMID: 26487785) Traurig M … Bogardus C (Diabetes 2016) 3 58
  5. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin SY … Soranzo N (Nature genetics 2014) 3 58

Products for RNASEK Gene

Sources for RNASEK Gene

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