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Aliases for RNASEK Gene

Aliases for RNASEK Gene

  • Ribonuclease, RNase K 2 3
  • RNase Kappa 4
  • EC 3.1.-.- 4
  • RNase K 4

External Ids for RNASEK Gene

Previous GeneCards Identifiers for RNASEK Gene

  • GC17P006862
  • GC17P006863
  • GC17P006915

Summaries for RNASEK Gene

GeneCards Summary for RNASEK Gene

RNASEK (Ribonuclease, RNase K) is a Protein Coding gene. GO annotations related to this gene include endoribonuclease activity.

UniProtKB/Swiss-Prot for RNASEK Gene

  • Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASEK Gene

Genomics for RNASEK Gene

Regulatory Elements for RNASEK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNASEK Gene

Start:
7,012,417 bp from pter
End:
7,014,533 bp from pter
Size:
2,117 bases
Orientation:
Plus strand

Genomic View for RNASEK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASEK Gene

Proteins for RNASEK Gene

  • Protein details for RNASEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5S7-RNK_HUMAN
    Recommended name:
    Ribonuclease kappa
    Protein Accession:
    Q6P5S7
    Secondary Accessions:
    • G3V1Z9
    • Q502Z2

    Protein attributes for RNASEK Gene

    Size:
    137 amino acids
    Molecular mass:
    15420 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH51802.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH62705.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF82619.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAN89245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNASEK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASEK Gene

Proteomics data for RNASEK Gene at MOPED

Post-translational modifications for RNASEK Gene

  • Ubiquitination at Lys132
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNASEK Gene

Domains for RNASEK Gene

Protein Domains for RNASEK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASEK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P5S7

UniProtKB/Swiss-Prot:

RNK_HUMAN :
  • Q6P5S7
Family:
  • Belongs to the RNase K family.
genes like me logo Genes that share domains with RNASEK: view

No data available for Gene Families for RNASEK Gene

Function for RNASEK Gene

Molecular function for RNASEK Gene

UniProtKB/Swiss-Prot Function: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.

Enzyme Numbers (IUBMB) for RNASEK Gene

Gene Ontology (GO) - Molecular Function for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004521 endoribonuclease activity IDA 17881363
genes like me logo Genes that share ontologies with RNASEK: view

Animal Model Products

CRISPR Products

miRNA for RNASEK Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASEK

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNASEK Gene

Localization for RNASEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASEK Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASEK Gene COMPARTMENTS Subcellular localization image for RNASEK gene
Compartment Confidence
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNASEK: view

Pathways for RNASEK Gene

SuperPathways for RNASEK Gene

No Data Available

Interacting Proteins for RNASEK Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000449500%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000449500 for RNASEK Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009303 rRNA transcription IDA 17881363
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASEK: view

No data available for Pathways by source for RNASEK Gene

Transcripts for RNASEK Gene

Unigene Clusters for RNASEK Gene

Ribonuclease, RNase K:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASEK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASEK Gene

No ASD Table

Relevant External Links for RNASEK Gene

GeneLoc Exon Structure for
RNASEK
ECgene alternative splicing isoforms for
RNASEK

Expression for RNASEK Gene

mRNA expression in normal human tissues for RNASEK Gene

mRNA differential expression in normal tissues according to GTEx for RNASEK Gene

This gene is overexpressed in Whole Blood (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNASEK Gene

SOURCE GeneReport for Unigene cluster for RNASEK Gene Hs.632232

mRNA Expression by UniProt/SwissProt for RNASEK Gene

Q6P5S7-RNK_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with RNASEK: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNASEK Gene

Orthologs for RNASEK Gene

This gene was present in the common ancestor of animals.

Orthologs for RNASEK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASEK 35
  • 100 (n)
  • 100 (a)
RNASEK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNASEK 35
  • 95.58 (n)
  • 98.98 (a)
RNASEK 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNASEK 35
  • 94.22 (n)
  • 94.9 (a)
RNASEK 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm21988 36
  • 100 (a)
OneToMany
Rnasek 35
  • 94.56 (n)
  • 100 (a)
Rnasek 16
Rnasek 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RNASEK 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNASEK 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnasek 35
  • 94.22 (n)
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493134 35
  • 78.57 (n)
  • 84.69 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100534769 35
  • 69.76 (n)
  • 74.23 (a)
rnaseka 36
  • 68 (a)
OneToMany
rnasekb 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG40127 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3620 36
  • 39 (a)
OneToOne
Species with no ortholog for RNASEK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNASEK Gene

ENSEMBL:
Gene Tree for RNASEK (if available)
TreeFam:
Gene Tree for RNASEK (if available)

Paralogs for RNASEK Gene

Selected SIMAP similar genes for RNASEK Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RNASEK: view

No data available for Paralogs for RNASEK Gene

Variants for RNASEK Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASEK Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv907634 CNV Loss 21882294
nsv457659 CNV Loss 19166990

Relevant External Links for RNASEK Gene

HapMap Linkage Disequilibrium report
RNASEK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RNASEK Gene

Disorders for RNASEK Gene

Relevant External Links for RNASEK

Genetic Association Database (GAD)
RNASEK
Human Genome Epidemiology (HuGE) Navigator
RNASEK
genes like me logo Genes that share disorders with RNASEK: view

No data available for UniProtKB/Swiss-Prot for RNASEK Gene

Publications for RNASEK Gene

  1. Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase. (PMID: 17881363) Economopoulou M.-A. … Sideris D.C. (Nucleic Acids Res. 2007) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Essential cysteine residues for human RNase I_ catalytic activity. (PMID: 22324914) Kiritsi M.N. … Sideris D.C. (FEBS J. 2012) 3
  5. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3

Products for RNASEK Gene

Sources for RNASEK Gene

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