RNASEK Gene
protein-coding GIFtS: 40
GCID: GC17P006915
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|
ribonuclease, RNase K
| |
Aliases for RNASEK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
| This gene clusters with an RNA gene Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Ribonuclease, RNase K1 2 | | RNase Kappa2 3 | | MGC719931 | | Ribonuclease Kappa2 | | EC 3.1.-.-3 | | RNase K3 |
| External Ids: | HGNC: 339111 | Entrez Gene: 4404002 | Ensembl: ENSG000002192007 | UniProtKB: Q6P5S73 | | ORGUL members: | |
|---|
| NONCODE:n410550 n410548 n410549 | |
Export aliases for RNASEK gene to outside databasesPrevious GC identifers: GC17P006862 GC17P006863
Summaries for RNASEK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RNK_HUMAN, Q6P5S7Function: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at alower rate
|
Genomic Views for RNASEK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RNASEK gene promoter: E2F-4 E2F-3a E2F-5 Spz1 Nkx2-5 E2F-2 POU3F2 E2F E2F-1 Sox9 Other transcription factors
Search SABiosciences Chromatin IP Primers for RNASEK
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASEK |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1RNASEK Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P006915: view genomic region
(about GC identifiers)
Start:
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6,915,736 bp from pter |
End:
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6,917,851 bp from pter |
Size:
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2,116 bases |
Orientation:
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plus strand |
ORGUL member locations: Legend (see complete legend)
6915735 6918289 6920843 chr17
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Proteins for RNASEK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RNK_HUMAN, Q6P5S7 (See
protein sequence)Recommended Name: Ribonuclease kappa Size: 98 amino acids; 10992 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for RNASEK: NX_Q6P5S7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P5S7 RNASEK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004333.2 ENSEMBL proteins: ENSP00000449500 ENSP00000447072 ENSP00000459471 ENSP00000447359 ENSP00000449670 ENSP00000450174 ENSP00000450182 ENSP00000385440 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0016021 | integral to membrane |
IEA | -- |
RNASEK for ontologies About GeneDecksing
RNASEK Antibody Products: Assay Products for RNASEK: |
Protein
Domains / Families for RNASEK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNASEK for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6P5S7ProtoNet protein and cluster: Q6P5S7 UniProtKB/Swiss-Prot: RNK_HUMAN, Q6P5S7Similarity: Belongs to the RNase K family |
Function for RNASEK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RNK_HUMAN, Q6P5S7Function: Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at alower rateEnzyme Number (IUBMB): EC 3.1.-.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASEK (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASEK (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNASEK (NM_001004333) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASEK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEK  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEK |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RNASEK for ontologies About GeneDecksing
|
Pathways & Interactions for RNASEK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASEK
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
RNASEK for ontologies About GeneDecksing
|
Drugs & Compounds for RNASEK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RNASEK Search CenterWatch for drugs/clinical trials and news about RNASEK / RNK 
|
Transcripts for RNASEK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RNASEK gene: NM_001004333.4 Unigene Cluster for RNASEK: Ribonuclease, RNase K Hs.632232 [show with all ESTs]Unigene Representative Sequence: BF2132709 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000548577 ENST00000546395 ENST00000570898 ENST00000552039 ENST00000552842 ENST00000575822 ENST00000549393 ENST00000552321 ENST00000402093
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASEK (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASEK (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNASEK (NM_001004333) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASEK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEK  |
Additional cDNA sequence: AK289930.1 AM746459.1 BC032510.2 BC051802.1 BC062705.1 BC070349.1 BC095436.1 NR_037715.1 NR_037716.1 13 DOTS entries: DT.100038061 DT.448584 DT.91683782 DT.100887873 DT.120994270 DT.95220070 DT.95244137 DT.95333750 DT.100887889 DT.95094098 DT.95178537 DT.100763830 DT.95276523 24/545 AceView cDNA sequences (see all 545): CB160051 AW025818 BU626017 AA931153 AI183273 AA588021 AA282509 BM991218 H22336 AK055800 R82586 AW470137 AA436860 BM694510 AA974927 AI460079 AA651826 AA287630 BU730728 AA496548 CR600192 AI829899 AI568306 AJ713634 GeneLoc Exon Structure
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Expression for RNASEK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNASEK expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GTGCGCTAGG
About this image See RNASEK Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RNASEK
SOURCE GeneReport for Unigene cluster: Hs.632232 UniProtKB/Swiss-Prot: RNK_HUMAN, Q6P5S7Tissue specificity: Widely expressed SABiosciences Custom PCR Arrays for RNASEK
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASEK Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASEK | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASEK | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASEK | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEK |
Orthologs for RNASEK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RNASEK gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for RNASEK (if available) TreeFam Gene Tree for RNASEK (if available)  |
Paralogs for RNASEK gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for RNASEK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RNASEK (6915736 - 6917851 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for RNASEK: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASEK |
|
Disorders
/ Diseases for RNASEK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNASEK for disorders About GeneDecksing
2 diseases for RNASEK: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma Human Genome Epidemiology (HuGE) Navigator: RNASEK (3 documents) Export disorders for RNASEK gene to outside databases
|
Publications for RNASEK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNASEK gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with RNASEK) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase. (PubMed id 17881363)1, 2, 3 Economopoulou M.A....Sideris D.C. (2007)
- Essential cysteine residues for human RNase k catalyti c activity. (PubMed id 22324914)1 Kiritsi M.N....Sideris D.C. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RNASEK gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
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Genome Databases showing RNASEK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNASEK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNASEK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RNASEK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNASEK gene: Search GeneIP for patents involving RNASEK
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RNASEK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for RNASEK | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASEK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASEK | | OriGene Protein Over-expression Lysate for RNASEK | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for RNASEK | | OriGene 3'-UTR Clone for RNASEK | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASEK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASEK | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for RNASEK | | OriGene Custom Protein Services for RNASEK | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASEK | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASEK | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASEK | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASEK | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASEK | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASEK |
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 |  |  |  | |
| | | Search Tocris compounds for RNASEK |
| |  |  |  |  | | | | |
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 | | RNASEK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEK |
|  |  |  | | | ThermoFisher Antibodies for RNASEK |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEK |
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Last full update: 18 Mar 2013 -
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