Aliases for RNASEH2C Gene
External Ids for RNASEH2C Gene
Previous GeneCards Identifiers for RNASEH2C Gene
This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNASEH2C Gene
RNASEH2C (Ribonuclease H2 Subunit C) is a Protein Coding gene. Diseases associated with RNASEH2C include Aicardi-Goutieres Syndrome 3 and Aicardi-Goutieres Syndrome. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis.
UniProtKB/Swiss-Prot for RNASEH2C Gene
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.