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RNASEH2C Gene

protein-coding   GIFtS: 51
GCID: GC11M065485

Ribonuclease H2, Subunit C

  See RNASEH2C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease H2, Subunit C1 2     RNase H1 Small Subunit2 3
AGS32 3 5     RNase H2 Subunit C2 3
AYP12 3 5     Aicardi-Goutieres Syndrome 31
Aicardi-Goutieres Syndrome 3 Protein2 3     Ribonuclease H2 Subunit C2
Ribonuclease HI Subunit C2 3     FLJ209745

External Ids:    HGNC: 241161   Entrez Gene: 841532   Ensembl: ENSG000001729227   OMIM: 6103305   UniProtKB: Q8TDP13   

Export aliases for RNASEH2C gene to outside databases

Previous GC identifers: GC11M065241 GC11M061811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNASEH2C Gene:
This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in
this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene
for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for RNASEH2C Gene:
RNASEH2C (ribonuclease H2, subunit C) is a protein-coding gene. Diseases associated with RNASEH2C include aicardi-goutieres syndrome type 3, and ipex syndrome.

UniProtKB/Swiss-Prot: RNH2C_HUMAN, Q8TDP1
Function: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA
hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment
RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RNASEH2C gene promoter:
         AP-2alpha isoform 3   STAT3   AP-2alpha isoform 2   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASEH2C promoter sequence
   Search Chromatin IP Primers for RNASEH2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASEH2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

RNASEH2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEH2C gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065485:  view genomic region     (about GC identifiers)

Start:
65,482,367 bp from pter      End:
65,488,418 bp from pter
Size:
6,052 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RNH2C_HUMAN, Q8TDP1 (See protein sequence)
Recommended Name: Ribonuclease H2 subunit C  
Size: 164 amino acids; 17840 Da
Subunit: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic
subunits RNASEH2B and RNASEH2C
Miscellaneous: The T6 pseudogene located upstream of SRY on chromosome Y is derived from the transcript of this
gene
2 PDB 3D structures from and Proteopedia for RNASEH2C:
3P56 (3D)        3PUF (3D)    
Secondary accessions: Q9H7F5
Alternative splicing: 2 isoforms:  Q8TDP1-1   Q8TDP1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RNASEH2C: NX_Q8TDP1

Explore proteomics data for RNASEH2C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys143
  • Modification sites at PhosphoSitePlus

  • See RNASEH2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115569.2  
    ENSEMBL proteins: 
     ENSP00000432081   ENSP00000308193   ENSP00000434996   ENSP00000435717   ENSP00000431555  
     ENSP00000432897  

    RNASEH2C Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RNASEH2C

     
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    antibodies-online proteins for RNASEH2C (4 products) 

     
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    antibodies-online kits for RNASEH2C (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013924 RNase_H2_suC

    Graphical View of Domain Structure for InterPro Entry Q8TDP1

    ProtoNet protein and cluster: Q8TDP1

    1 Blocks protein domain: IPB013924 Ribonuclease H1 small subunit

    UniProtKB/Swiss-Prot: RNH2C_HUMAN, Q8TDP1
    Similarity: Belongs to the RNase H2 subunit C family


    Find genes that share domains with RNASEH2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNH2C_HUMAN, Q8TDP1
    Function: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA
    hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment
    RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes

    Phenotypes:
         2 GenomeRNAi human phenotypes for RNASEH2C:

     G0/1 arrest  Increased G1 DNA content 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rnaseh2c):
     mortality/aging 

    Find genes that share phenotypes with RNASEH2C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rnaseh2ctm1(KOMP)Wtsi for RNASEH2C

       genOway: Develop your customized and physiologically relevant rodent model for RNASEH2C

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RNASEH2C (see all 11):
    hsa-miR-1321 hsa-let-7a-2* hsa-miR-1224-5p hsa-miR-508-3p hsa-miR-637 hsa-let-7g* hsa-miR-342-5p hsa-miR-2114*
    SwitchGear 3'UTR luciferase reporter plasmidRNASEH2C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNASEH2C

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    GenScript: all cDNA clones in your preferred vector: RNASEH2C (NM_032193)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEH2C

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEH2C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNH2C_HUMAN, Q8TDP1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0032299ribonuclease H2 complex IDA--

    Find genes that share ontologies with RNASEH2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNASEH2C About    
    See pathways by source

    SuperPathContained pathways About
    1DNA strand elongation
    DNA replication0.63


    Find genes that share SuperPaths with RNASEH2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RNASEH2C):
        DNA replication

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASEH2C
    Interactions:

        Search GeneGlobe Interaction Network for RNASEH2C

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RNASEH2C (ENSP000003081934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNASEH2AENSP000002214864STRING: ENSP00000221486
    RNASEH2BENSP000003376234STRING: ENSP00000337623
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process IDA--

    Find genes that share ontologies with RNASEH2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASEH2C (RNH2C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNASEH2C gene: 
    NM_032193.3  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534482 ENST00000308418(uc001ofm.3 uc001ofn.3) ENST00000533698
    ENST00000531596 ENST00000528220 ENST00000527610 ENST00000530192
    miRNA
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    Block miRNA regulation of human, mouse, rat RNASEH2C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RNASEH2C (see all 11):
    hsa-miR-1321 hsa-let-7a-2* hsa-miR-1224-5p hsa-miR-508-3p hsa-miR-637 hsa-let-7g* hsa-miR-342-5p hsa-miR-2114*
    SwitchGear 3'UTR luciferase reporter plasmidRNASEH2C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNASEH2C
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    GenScript: all cDNA clones in your preferred vector: RNASEH2C (NM_032193)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASEH2C
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASEH2C
      QuantiTect SYBR Green Assays in human, mouse, rat RNASEH2C
      QuantiFast Probe-based Assays in human, mouse, rat RNASEH2C

    Selected AceView cDNA sequences (see all 136):

    BM666847 AI868488 AF346606 CN482295 BQ935095 BI835854 BE883033 BQ012867 
    BI754174 CR602154 AF312034 AW163159 BX281872 AI867491 BF508946 AI344635 
    AW245300 AW241152 BE870329 BQ012372 BM695064 BE672843 NM_032193 BF339379 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RNASEH2C    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
    SP1:              -                       -     -                     
    SP2:              -                                                   
    SP3:                                      -     -                     
    SP4:              -                                                   
    SP5:                                -     -                           


    ECgene alternative splicing isoforms for RNASEH2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASEH2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTTTCCC
    RNASEH2C Expression
    About this image

    RNASEH2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASEH2C Protein Expression

    UniProtKB/Swiss-Prot: RNH2C_HUMAN, Q8TDP1
    Tissue specificity: Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEH2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNASEH2C gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnaseh2c1 , 5 ribonuclease H2, subunit C1, 5 73.98(n)1
    66.46(a)1
      19 (4.34 cM)5
    682091  NM_026616.21  NP_080892.11 
     56018735 
    zebrafish
    (Danio rerio)
    Actinopterygii RNASEH2C (1 of 2)6
    RNASEH2C (2 of 2)6
    ribonuclease H2, subunit C
    39(a)
    39(a)
    many → 1
    many → 1
    14(36567058-36571913) ENSDARG00000089637
    14(36630529-36631399) ENSDARG00000091285
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301056
    --
    25(a)
    1 ↔ 1
    2R(13479309-13480014)


    ENSEMBL Gene Tree for RNASEH2C (if available)
    TreeFam Gene Tree for RNASEH2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNASEH2C gene

    Find genes that share paralogs with RNASEH2C           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RNASEH2C
    PGOHUM00000233889


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNASEH2C (see all 73)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0272874
    Aicardi-Goutieres syndrome 3 (AGS3)4--see VAR_0272872 R W mis40--------
    VAR_0706194
    Aicardi-Goutieres syndrome 3 (AGS3)4--see VAR_0706192 D Y mis40--------
    VAR_0706204
    Aicardi-Goutieres syndrome 3 (AGS3)4--see VAR_0706202 P L mis40--------
    VAR_0706224
    Aicardi-Goutieres syndrome 3 (AGS3)4--see VAR_0706222 P S mis40--------
    VAR_0706184
    Aicardi-Goutieres syndrome 3 (AGS3)4--see VAR_0706182 R H mis40--------
    VAR_0706214
    Aicardi-Goutieres syndrome 3 (AGS3)4--see VAR_0706212 P L mis40--------
    VAR_0272884
    Aicardi-Goutieres syndrome 3 (AGS3)4--see VAR_0272882 K I mis40--------
    rs751461581,2
    Cpathogenic165408333(-) TGCCAA/TAGTGC 2 K I mis10--------
    rs786357981,2
    Cpathogenic165408633(-) GTCTAC/TGGGGA 2 R W mis10--------
    rs1169027361,2
    F--65409795(+) GTTTGG/ATCTTT 1 -- us2k11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for RNASEH2C (65482367 - 65488418 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNASEH2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897718CNV Loss21882294
    nsv897736CNV Loss21882294

    Human Gene Mutation Database (HGMD): RNASEH2C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASEH2C
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASEH2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610330   
    OMIM disorders: 610329  
    UniProtKB/Swiss-Prot: RNH2C_HUMAN, Q8TDP1
  • Aicardi-Goutieres syndrome 3 (AGS3) [MIM:610329]: A form of Aicardi-Goutieres syndrome, a genetically
    heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications,
    chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic
    investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and
    elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe
    neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and
    profound psychomotor retardation. Death often occurs in early childhood. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 4 diseases for RNASEH2C:    
    About MalaCards
    aicardi-goutieres syndrome type 3    ipex syndrome    aicardi-goutieres syndrome    aicardi-goutieres syndrome 7

    1 disease from the University of Copenhagen DISEASES database for RNASEH2C:
    Aicardi-Goutieres syndrome

    Find genes that share disorders with RNASEH2C           About GenesLikeMe

    GeneTests: RNASEH2C
    GeneReviews: RNASEH2C

    Export disorders for RNASEH2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNASEH2C gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RNASEH2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in genes encoding ribonuclease H2 subunits cause Aicardi- Goutieres syndrome and mimic congenital viral brain infection. (PubMed id 16845400)1, 2, 3 Crow Y.J....Jackson A.P. (Nat. Genet. 2006)
    2. Clinical and molecular phenotype of Aicardi-Goutieres syndrome. (PubMed id 17846997)1, 2 Rice G....Crow Y.J. (Am. J. Hum. Genet. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Evidence that the SRY protein is encoded by a single exon on the human Y chromosome. (PubMed id 8244390)1, 3 Behlke M.A.... Page D.C. (Genomics 1993)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84153 HGNC: 24116 AceView: AYP1 Ensembl:ENSG00000172922 euGenes: HUgn84153
    ECgene: RNASEH2C Kegg: 84153 H-InvDB: RNASEH2C

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNASEH2C Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=RNASEH2C[genesymbol]

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    Patent Information for RNASEH2C gene:
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