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RNASEH2B Gene

protein-coding   GIFtS: 53
GCID: GC13P051483

Ribonuclease H2, Subunit B

(Previous names: deleted in lymphocytic leukemia 8, Aicardi-Goutieres syndrome...)
(Previous symbols: DLEU8, AGS2)
  See RNASEH2B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease H2, Subunit B1 2     Aicardi-Goutieres Syndrome 2 Protein2 3
AGS21 2 3 5     RNase H2 Subunit B2 3
DLEU81 2 3 5     Aicardi-Goutieres Syndrome 21
Deleted In Lymphocytic Leukemia 81 2 3     Ribonuclease H2 Subunit B2
Ribonuclease HI Subunit B2 3     FLJ117125

External Ids:    HGNC: 256711   Entrez Gene: 796212   Ensembl: ENSG000001361047   OMIM: 6103265   UniProtKB: Q5TBB13   

Export aliases for RNASEH2B gene to outside databases

Previous GC identifers: GC13P050382 GC13P032272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNASEH2B Gene:
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically
degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2,
which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have
been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). (provided
by RefSeq, Nov 2008)

GeneCards Summary for RNASEH2B Gene:
RNASEH2B (ribonuclease H2, subunit B) is a protein-coding gene. Diseases associated with RNASEH2B include aicardi-goutieres syndrome type 2, and aicardi-goutieres syndrome.

UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1
Function: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA
hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment
RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASEH2B gene promoter:
         AhR   IRF-1   c-Ets-1   GATA-1   Meis-1b   IRF-2   Pax-3   IRF-7A   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASEH2B promoter sequence
   Search Chromatin IP Primers for RNASEH2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASEH2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3   Ensembl cytogenetic band:  13q14.3   HGNC cytogenetic band: 13q14.3

RNASEH2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEH2B gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P051483:  view genomic region     (about GC identifiers)

Start:
51,483,814 bp from pter      End:
51,544,596 bp from pter
Size:
60,783 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1 (See protein sequence)
Recommended Name: Ribonuclease H2 subunit B  
Size: 312 amino acids; 35139 Da
Subunit: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic
subunits RNASEH2B and RNASEH2C
Sequence caution: Sequence=AAH01397.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH07332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH10174.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
3 PDB 3D structures from and Proteopedia for RNASEH2B:
3P56 (3D)        3P87 (3D)        3PUF (3D)    
Secondary accessions: Q6PK48 Q9HAF7

Explore the universe of human proteins at neXtProt for RNASEH2B: NX_Q5TBB1

Explore proteomics data for RNASEH2B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys230
  • Modification sites at PhosphoSitePlus

  • See RNASEH2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135751.1  NP_078846.2  

    ENSEMBL proteins: 
     ENSP00000337623   ENSP00000389877  

    RNASEH2B Human Recombinant Protein Products:

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    antibodies-online peptides for RNASEH2B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019024 RNase_H2_suB

    Graphical View of Domain Structure for InterPro Entry Q5TBB1

    ProtoNet protein and cluster: Q5TBB1

    UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1
    Similarity: Belongs to the RNase H2 subunit B family


    Find genes that share domains with RNASEH2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNH2B_HUMAN, Q5TBB1
    Function: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA
    hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment
    RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004523RNA-DNA hybrid ribonuclease activity IEA--
         
    Find genes that share ontologies with RNASEH2B           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rnaseh2b):
     cellular  embryogenesis  growth/size/body  immune system  mortality/aging 
     nervous system 

    Find genes that share phenotypes with RNASEH2B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNASEH2B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASEH2B
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    miRNA
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    miRTarBase miRNAs that target RNASEH2B:
    hsa-mir-328-3p (MIRT043749)

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    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidRNASEH2B 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for RNASEH2B
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNH2B_HUMAN, Q5TBB1: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0032299ribonuclease H2 complex IDA--

    Find genes that share ontologies with RNASEH2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNASEH2B About    
    See pathways by source

    SuperPathContained pathways About
    1DNA strand elongation
    DNA replication0.63


    Find genes that share SuperPaths with RNASEH2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for RNASEH2B):
        DNA replication

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASEH2B
    Interactions:

        Search GeneGlobe Interaction Network for RNASEH2B

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RNASEH2B (ENSP000003376234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNASEH2AENSP000002214864STRING: ENSP00000221486
    RNASEH2CENSP000003081934STRING: ENSP00000308193
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006401RNA catabolic process IDA--
    GO:0009259ribonucleotide metabolic process IEA--
    GO:0010389regulation of G2/M transition of mitotic cell cycle IEA--
    GO:0010629negative regulation of gene expression IEA--

    Find genes that share ontologies with RNASEH2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASEH2B (RNH2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNASEH2B gene (2 alternative transcripts): 
    NM_001142279.2  NM_024570.3  

    Unigene Cluster for RNASEH2B:

    Ribonuclease H2, subunit B
    Hs.306291  [show with all ESTs]
    Unigene Representative Sequence: AK124228
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336617(uc001vfa.4) ENST00000495244 ENST00000459681 ENST00000465541
    ENST00000422660(uc001vfb.4)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate RNASEH2B:
    hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidRNASEH2B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RNASEH2B
      QuantiFast Probe-based Assays in human, mouse, rat RNASEH2B

    Additional mRNA sequence: 

    AK021774.1 AK022667.1 AK124228.1 AK223340.1 AL049218.1 AY764036.1 BC001397.2 BC005088.1 
    BC007332.2 BC010174.2 BC036744.1 

    11 DOTS entries:

    DT.413360  DT.402826  DT.403040  DT.101975965  DT.91839930  DT.75171094  DT.95374505  DT.100784433 
    DT.40131615  DT.120775818  DT.91798778 

    Selected AceView cDNA sequences (see all 152):

    BI753018 BC010174 BE222563 AA758833 BC007332 AK021774 CD516977 AI831935 
    CR608889 AI200850 NM_024570 AK022667 CB052210 AA969739 AW439381 BF509470 
    AI024902 AA259151 CR621824 BG261287 AA831538 BU195143 BU175622 AI494520 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNASEH2B (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
    SP1:              -     -     -                                                                 -           -         
    SP2:                                                                                                                  
    SP3:                          -                                                                                       
    SP4:              -     -                                                                                             
    SP5:                                                                                            -                     


    ECgene alternative splicing isoforms for RNASEH2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASEH2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGATATC
    RNASEH2B Expression
    About this image

    RNASEH2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASEH2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.306291

    UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1
    Tissue specificity: Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RNASEH2B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnaseh2b1 , 5 ribonuclease H2, subunit B1, 5 84.36(n)1
    82.08(a)1
      14 (33.19 cM)5
    671531  NM_026001.21  NP_080277.11 
     622925895 
    chicken
    (Gallus gallus)
    Aves RNASEH2B1 ribonuclease H2, subunit B 65.67(n)
    59.4(a)
      418874  NM_001030826.1  NP_001025997.1 
    lizard
    (Anolis carolinensis)
    Reptilia RNASEH2B6
    ribonuclease H2, subunit B
    57(a)
    1 ↔ 1
    1(140179736-140198333)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.39612 Transcribed sequence with weak similarity to protein more 70.77(n)    BX741964.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc566022 hypothetical protein MGC56602 74.19(n)   393241  BC049050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111641 CG11164 43.91(n)
    34.69(a)
      32323  NM_132680.3  NP_572908.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F21D5.66
    Protein F21D5.6 (F21D5.6) mRNA, complete cds
    22(a)
    1 ↔ 1
    IV(8740137-8741388) WBGene00009011


    ENSEMBL Gene Tree for RNASEH2B (if available)
    TreeFam Gene Tree for RNASEH2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNASEH2B (see all 1083)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0272814
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0272812 H R mis40--------
    VAR_0272834
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0272832 T I mis40--------
    VAR_0706154
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0706152 S I mis40--------
    VAR_0272864
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0272862 Y H mis40--------
    VAR_0272844
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0272842 A T mis40--------
    VAR_0706144
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0706142 L F mis40--------
    VAR_0706124
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0706122 W L mis40--------
    VAR_0706134
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0706132 G S mis40--------
    VAR_0706114
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0706112 P H mis40--------
    VAR_0706164
    Aicardi-Goutieres syndrome 2 (AGS2)4--see VAR_0706162 V M mis40--------

    HapMap Linkage Disequilibrium report for RNASEH2B (51483814 - 51544596 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNASEH2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676765CNV Deletion23128226
    nsv826645CNV Loss20364138
    nsv900077CNV Loss21882294

    Human Gene Mutation Database (HGMD): RNASEH2B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASEH2B
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASEH2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610326   
    OMIM disorders: 610181  
    UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1
  • Aicardi-Goutieres syndrome 2 (AGS2) [MIM:610181]: A form of Aicardi-Goutieres syndrome, a genetically
    heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications,
    chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic
    investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and
    elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe
    neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and
    profound psychomotor retardation. Death often occurs in early childhood. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 3 diseases for RNASEH2B:    
    About MalaCards
    aicardi-goutieres syndrome type 2    aicardi-goutieres syndrome    aicardi-goutieres syndrome 7

    1 disease from the University of Copenhagen DISEASES database for RNASEH2B:
    Aicardi-Goutieres syndrome

    Find genes that share disorders with RNASEH2B           About GenesLikeMe

    GeneTests: RNASEH2B
    GeneReviews: RNASEH2B

    Export disorders for RNASEH2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNASEH2B gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with RNASEH2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in genes encoding ribonuclease H2 subunits cause Aicardi- Goutieres syndrome and mimic congenital viral brain infection. (PubMed id 16845400)1, 2, 3 Crow Y.J....Jackson A.P. (Nat. Genet. 2006)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Different mutations in three prime repair exonuclease 1 and ribonuclease H2 genes affect clinical features in Aicardi-Goutieres syndrome. (PubMed id 21862834)1 Izzotti A....Pulliero A. (J. Child Neurol. 2012)
    7. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    8. A novel RNASEH2B splice site mutation responsible for Aicardi-Goutieres syndrome in the Faroe Islands. (PubMed id 22882256)1 Ostergaard E....Born A.P. (Acta Paediatr. 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79621 HGNC: 25671 AceView: FLJ11712 Ensembl:ENSG00000136104 euGenes: HUgn79621
    ECgene: RNASEH2B Kegg: 79621 H-InvDB: RNASEH2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNASEH2B Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=RNASEH2B[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNASEH2B gene:
    Search GeneIP for patents involving RNASEH2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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