Aliases for RNASEH2B Gene
External Ids for RNASEH2B Gene
Previous HGNC Symbols for RNASEH2B Gene
Previous GeneCards Identifiers for RNASEH2B Gene
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
GeneCards Summary for RNASEH2B Gene
RNASEH2B (Ribonuclease H2 Subunit B) is a Protein Coding gene. Diseases associated with RNASEH2B include Aicardi-Goutieres Syndrome 2 and Aicardi-Goutieres Syndrome 1, Dominant And Recessive. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include RNA-DNA hybrid ribonuclease activity.
UniProtKB/Swiss-Prot for RNASEH2B Gene
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.