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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNASEH2B Gene

protein-coding GIFtS: 50
GCID: GC13P051483

ribonuclease H2, subunit B

(Previous names: deleted in lymphocytic leukemia 8, Aicardi-Goutieres syndrome...)
(Previous symbols: DLEU8, AGS2)

Explore 11 diseases affiliated with
RNASEH2B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribonuclease H2, Subunit B¹ ²		Aicardi-Goutieres Syndrome 2 Protein² ³
AGS2¹ ² ³ ⁵		RNase H2 Subunit B² ³
DLEU8¹ ² ³ ⁵		FLJ11712¹ ⁵
Deleted In Lymphocytic Leukemia 8¹ ² ³		Aicardi-Goutieres Syndrome 2¹
Ribonuclease HI Subunit B² ³		Ribonuclease H2 Subunit B²

External Ids:	HGNC: 25671¹	Entrez Gene: 79621²	Ensembl: ENSG00000136104⁷	OMIM: 610326⁵	UniProtKB: Q5TBB1³

Export aliases for RNASEH2B gene to outside databases

Previous GC identifers: GC13P050382 GC13P032272

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNASEH2B:

RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically

degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2,

which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been

found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). (provided by

RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1

Function: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids.

Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers

during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNASEH2B gene promoter:
AhR IRF-1 c-Ets-1 GATA-1 Meis-1b IRF-2 Pax-3 IRF-7A Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASEH2B promoter sequence

Search SABiosciences Chromatin IP Primers for RNASEH2B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASEH2B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.3

RNASEH2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEH2B gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P051483: view genomic region (about GC identifiers)

Start:	51,483,814 bp from pter	End:	51,544,596 bp from pter
Size:	60,783 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1 (See protein sequence)

Recommended Name: Ribonuclease H2 subunit B

Size: 312 amino acids; 35139 Da

Subunit: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic

subunits RNASEH2B and RNASEH2C

Subcellular location: Nucleus (Probable)

Sequence caution: Sequence=AAH01397.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=AAH07332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH10174.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

3 PDB 3D structures from and Proteopedia for RNASEH2B:

3P56 (3D)

3P87 (3D)

3PUF (3D)

Secondary accessions: Q6PK48 Q9HAF7

Explore the universe of human proteins at neXtProt for RNASEH2B: NX_Q5TBB1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5TBB1

RNASEH2B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001135751.1 NP_078846.2

ENSEMBL proteins:

ENSP00000337623 ENSP00000389877

Human Recombinant Protein Products:

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	Novus Biologicals RNASEH2B Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RNASEH2B

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0032299	ribonuclease H2 complex	IDA	--

RNASEH2B for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RNASEH2B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNASEH2B for domains About GeneDecksing

1 InterPro domain/family:

IPR019024 RNase_H2_suB

Graphical View of Domain Structure for InterPro Entry Q5TBB1

ProtoNet protein and cluster: Q5TBB1

UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1

Similarity: Belongs to the RNase H2 subunit B family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1

Function: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids.

Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers

during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RNASEH2B Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASEH2B
		1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASEH2B:
		hsa-miR-3163
		SwitchGear 3'UTR luciferase reporter plasmid: RNASEH2B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASEH2B (see all 7) OriGene shRNA RFP: RNASEH2B OriGene siRNA: RNASEH2B
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RNASEH2B

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEH2B

Animal Models:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rnaseh2b):

cellular	embryogenesis	growth/size	immune system	mortality/aging
nervous system

RNASEH2B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Lagging Strand Synthesis

DNA replication

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for RNASEH2B):

DNA replication

RNASEH2B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNASEH2B

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for RNASEH2B (ENSP00000337623⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RNASEH2A	ENSP00000221486⁴	STRING: ENSP00000221486
RNASEH2C	ENSP00000308193⁴	STRING: ENSP00000308193
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006401	RNA catabolic process	IDA	--

RNASEH2B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNASEH2B
Search CenterWatch for drugs/clinical trials and news about RNASEH2B / RNH2B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNASEH2B gene (2 alternative transcripts):

NM_001142279.2 NM_024570.3

Unigene Cluster for RNASEH2B:

Ribonuclease H2, subunit B

Hs.306291 [show with all ESTs]

Unigene Representative Sequence: AK124228

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336617(uc001vfa.4) ENST00000494721 ENST00000459983 ENST00000495244

ENST00000459681 ENST00000465541 ENST00000422660(uc001vfb.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RNASEH2B Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASEH2B
		1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASEH2B:
		hsa-miR-3163
		SwitchGear 3'UTR luciferase reporter plasmid: RNASEH2B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASEH2B (see all 7) OriGene shRNA RFP: RNASEH2B OriGene siRNA: RNASEH2B
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Additional cDNA sequence:

AK021774.1 AK022667.1 AK124228.1 AK223340.1 AL049218.1 AY764036.1 BC001397.2 BC005088.1

BC007332.2 BC010174.2 BC036744.1

11 DOTS entries:

DT.413360 DT.402826 DT.403040 DT.101975965 DT.91839930 DT.75171094 DT.95374505 DT.100784433

DT.40131615 DT.120775818 DT.91798778

24/152 AceView cDNA sequences (see all 152):

BE222563 BG261287 AA758833 CA502990 AI804157 AI200850 BF509470 CA310157

BC001397 BQ216110 AK021774 AI494520 AA969739 AI831935 AW439381 BI908189

AK022667 NM_024570 BX100224 BC007332 CA309004 BG393104 BM450834 CB052210

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RNASEH2B (see all 6) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14
SP1:					-		-		-																						-				-
SP2:
SP3:									-
SP4:					-		-
SP5:																															-

ECgene alternative splicing isoforms for RNASEH2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASEH2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTGATATC

About this image

RNASEH2B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RNASEH2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASEH2B

SOURCE GeneReport for Unigene cluster: Hs.306291

UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1

Tissue specificity: Widely expressed

SABiosciences Custom PCR Arrays for RNASEH2B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNASEH2B gene from 9/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnaseh2b^{1 , 5}	ribonuclease H2, subunit B^{1, 5}	84.36(n)¹ 82.08(a)¹		14 (33.19 cM)⁵ 67153¹ NM_026001.2¹ NP_080277.1¹ 62292589⁵
chicken (Gallus gallus)	Aves	RNASEH2B¹	ribonuclease H2, subunit B	65.67(n) 59.4(a)		418874 NM_001030826.1 NP_001025997.1
lizard (Anolis carolinensis)	Reptilia	RNASEH2B⁶	--	58(a)	1 ↔ 1	1(140179736-140194202)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.3961²	Transcribed sequence with weak similarity to protein more	70.77(n)		BX741964.1
zebrafish (Danio rerio)	Actinopterygii	zgc56602²	hypothetical protein MGC56602	74.19(n)		393241 BC049050.1
fruit fly (Drosophila melanogaster)	Insecta	CG11164¹	CG11164	45.36(n) 36.07(a)		32323 NM_132680.2 NP_572908.2
worm (Caenorhabditis elegans)	Secernentea	F21D5.6⁶	Protein F21D5.6	23(a)	1 ↔ 1	IV(8740124-8741377)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G20325⁶	ribonuclease H2 subunit B	26(a)	1 ↔ 1	4(10979741-10982646)
rice (Oryza sativa)	Liliopsida	--	ribonuclease H2 subunit B, putative, expressed	25(a)	1 ↔ 1	4(23658401-23662791)

ENSEMBL Gene Tree for RNASEH2B (if available)
TreeFam Gene Tree for RNASEH2B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78847362^1,2	C,	pathogenic	32292629(+)	`ATCAGA/G/TTAGGT`	2	--	spd¹		0	--	--	--	--
rs75184679^1,2	C,F	pathogenic	32308493(+)	`TGGCAG/ACATTA`	4	/T /A	mis¹		2		NA EU	5873
rs74555752^1,2	C	pathogenic	32308518(+)	`GAATGG/TCAGTT`	4	G V	mis¹		0	--	--	--	--
rs1041017^1,2	C,F,A,H,	--	32271007(+)	`AGTTTC/TGCTTT`	2	--	us2k¹ tfbs³		21		NS EA NA WA CSA	2563
rs9526703^1,2	C,	--	32271569(+)	`GCAAGA/GGGCGC`	2	--	us2k¹		3		WA NA	240
rs61962192^1,2		--	32272095(+)	`GCTAAC/TTTTTG`	2	--	us2k¹		1		NA	2
rs113309899^1,2		--	32272454(+)	`CACCTG/CTTTTA`	2	--	us2k¹		1		CSA	1
rs80249109^1,2	F,	--	32272535(+)	`AGCAAC/GACAGA`	2	--	us2k¹		1		WA	118
rs116205353^1,2	C,F,	--	32272622(+)	`CTGCTA/GTTGTC`	2	--	us2k¹		1		WA	118
rs112702177^1,2		--	32272914(+)	`CCCTCC/GCCTGG`	2	--	ut5¹		1		CSA	1

HapMap Linkage Disequilibrium report for RNASEH2B (51483814 - 51544596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNASEH2B: --
Human Gene Mutation Database (HGMD): RNASEH2B

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASEH2B

DNA2.0 Custom Variant and Variant Library Synthesis for RNASEH2B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNASEH2B for disorders           About GeneDecksing

OMIM gene information: 610326
OMIM disorders: 610181
UniProtKB/Swiss-Prot: RNH2B_HUMAN, Q5TBB1

Defects in RNASEH2B are a cause of Aicardi-Goutieres syndrome type 2 (AGS2) [MIM:610181]. A form of

Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy,

leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF

alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as

thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously

suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly,

spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood

11 diseases for RNASEH2B: About MalaCards

aicardi-goutieres syndrome aicardi-goutieres syndrome type 2 lymphocytic leukemia leukemia

cerebral atrophy aspergillosis microcephaly parkinson's disease

spasticity cerebritis hepatitis

1 disease from the University of Copenhagen DISEASES database for RNASEH2B:

Aicardi-Goutieres syndrome

GeneTests: RNASEH2B

Aicardi-Goutieres Syndrome

Export disorders for RNASEH2B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RNASEH2B gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with RNASEH2B)

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Mutations in genes encoding ribonuclease H2 subunits cause Aicardi- Goutieres syndrome and mimic congenital viral brain infection. (PubMed id 16845400)^{1, 2, 3} Crow Y.J....Jackson A.P. (2006)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Different mutations in three prime repair exonuclease 1 and ribonuclease H2 genes affect clinical features in Aicardi-Goutieres syndro me. (PubMed id 21862834)¹ Izzotti A....Pulliero A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79621	HGNC: 25671	AceView: FLJ11712	Ensembl:ENSG00000136104	euGenes: HUgn79621
ECgene: RNASEH2B	Kegg: 79621	H-InvDB: RNASEH2B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RNASEH2B	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RNASEH2B

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RNASEH2B Gene

ribonuclease H2, subunit B

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RNASEH2B Gene

ribonuclease H2, subunit B

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