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RNASEH1 Gene

protein-coding   GIFtS: 61
GCID: GC02M003592

Ribonuclease H1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease H11 2
RNase H11 2 3
Ribonuclease H Type II2 3
RNH12 3
H1RNA2
EC 3.1.26.43

External Ids:    HGNC: 184661   Entrez Gene: 2462432   Ensembl: ENSG000001718657   OMIM: 6041235   UniProtKB: O609303   

Export aliases for RNASEH1 gene to outside databases

Previous GC identifers: GC02M003070 GC02M003234 GC02M003157 GC02M003158 GC02M003085 GC02M003570 GC02M003535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNASEH1 Gene:
This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA
replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from
translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces
the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of
the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first
initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter
isoform. This gene has three pseudogenes; two of them are on different locations of chromosome 17 and one of them
is on chromosome 1q32.2. (provided by RefSeq, Nov 2013)

GeneCards Summary for RNASEH1 Gene:
RNASEH1 (ribonuclease H1) is a protein-coding gene. Diseases associated with RNASEH1 include swine influenza, and cartilage-hair hypoplasia. GO annotations related to this gene include RNA binding and nucleic acid binding. An important paralog of this gene is ENSG00000255767.

UniProtKB/Swiss-Prot: RNH1_HUMAN, O60930
Function: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids

Gene Wiki entry for RNASEH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005334.17  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASEH1 gene promoter:
         GR   GR-beta   IRF-1   CUTL1   Evi-1   PPAR-gamma1   E2F-1   HOXA5   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASEH1 promoter sequence
   Search Chromatin IP Primers for RNASEH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASEH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25

RNASEH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEH1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M003592:  view genomic region     (about GC identifiers)

Start:
3,592,383 bp from pter      End:
3,606,206 bp from pter
Size:
13,824 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RNH1_HUMAN, O60930 (See protein sequence)
Recommended Name: Ribonuclease H1  
Size: 286 amino acids; 32064 Da
Cofactor: Binds 1 magnesium ion per subunit. May bind a second metal ion at a regulatory site, or after substrate
binding
Subunit: Monomer (Probable)
4 PDB 3D structures from and Proteopedia for RNASEH1:
2QK9 (3D)        2QKB (3D)        2QKK (3D)        3BSU (3D)    
Secondary accessions: B3KQU4 O60523 O60857 Q57Z93 Q5U0C1 Q6FHD4

Explore the universe of human proteins at neXtProt for RNASEH1: NX_O60930

Explore proteomics data for RNASEH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RNASEH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273763.1  NP_001273766.1  NP_002927.2  

    ENSEMBL proteins: 
     ENSP00000404926   ENSP00000313350   ENSP00000411646  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR009027 Ribosomal_L9/RNase_H1_N
     IPR017067 RNase_H1_euk
     IPR012337 RNaseH-like_dom
     IPR011320 RNase_H1_N
     IPR002156 RNaseH_domain

    Graphical View of Domain Structure for InterPro Entry O60930

    ProtoNet protein and cluster: O60930

    1 Blocks protein domain: IPB002156 RNase H

    UniProtKB/Swiss-Prot: RNH1_HUMAN, O60930
    Similarity: Belongs to the RNase H family
    Similarity: Contains 1 RNase H domain


    RNASEH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNH1_HUMAN, O60930
    Function: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids
    Catalytic activity: Endonucleolytic cleavage to 5'-phosphomonoester
    Enzyme regulation: In the presence of magnesium, manganese is inhibitory

         Genatlas biochemistry entry for RNASEH1:
    ribonuclease,RNAse H family,1,ubiquitously expressed,located in the SMCR critical region

         Enzyme Number (IUBMB): EC 3.1.26.41

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003676nucleic acid binding TAS9799596
    GO:0003723RNA binding TAS9799596
    GO:0004523RNA-DNA hybrid ribonuclease activity IEA--
    GO:0004540ribonuclease activity TAS9799596
         
    RNASEH1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rnaseh1):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    RNASEH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rnaseh1tm1Crh for RNASEH1

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    Block miRNA regulation of human, mouse, rat RNASEH1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RNASEH1:
    hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidRNASEH1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNH1_HUMAN, O60930: Cytoplasm (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    peroxisome2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IEA--

    RNASEH1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNASEH1 About    
    See pathways by source

    SuperPathContained pathways About
    1DNA strand elongation
    DNA replication0.63
    2Telomere C-strand (Lagging Strand) Synthesis
    Cell cycle Transition and termination of DNA replication0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for RNASEH1
        Cell cycle Transition and termination of DNA replication



    1 Kegg Pathway  (Kegg details for RNASEH1):
        DNA replication


    RNASEH1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASEH1
    Interactions:

        Search GeneGlobe Interaction Network for RNASEH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RNASEH1 (O609303 ENSP000003133504) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4IPQ5VYV73, ENSP000003355574I2D: score=1 STRING: ENSP00000335557
    VARS2ENSP000003948024STRING: ENSP00000394802 STRING: ENSP00000316092
    RNASEH2AENSP000002214864STRING: ENSP00000221486
    SSBP1ENSP000002653044STRING: ENSP00000265304
    RPA1ENSP000002547194STRING: ENSP00000254719
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006264mitochondrial DNA replication IEA--
    GO:0006401RNA catabolic process TAS9799596
    GO:0090501RNA phosphodiester bond hydrolysis TAS9799596

    RNASEH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASEH1 (RNH1)

    2 HMDB Compounds for RNASEH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    6 Novoseek inferred chemical compound relationships for RNASEH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxyribonucleotide 79.9 1 17028157 (1)
    oligoribonucleotide 69.6 1 14506260 (1)
    carboxylate 53.9 1 17226948 (1)
    ribose 44.7 2 8389211 (2)
    oligonucleotide 20 1 14500841 (1)
    alanine 3.92 2 12473655 (1), 14506260 (1)



    RNASEH1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNASEH1 gene (3 alternative transcripts): 
    NM_001286834.1  NM_001286837.1  NM_002936.4  

    Unigene Cluster for RNASEH1:

    Ribonuclease H1
    Hs.568006  [show with all ESTs]
    Unigene Representative Sequence: AK027610
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436842(uc002qxs.3) ENST00000315212(uc002qxt.3) ENST00000464986
    ENST00000454734
    miRNA
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    hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidRNASEH1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat RNASEH1
      QuantiFast Probe-based Assays in human, mouse, rat RNASEH1

    Additional mRNA sequence: 

    AF039652.1 AF048994.1 AF048995.1 AJ224117.1 AK027610.1 AK075490.1 AK096913.1 BC002973.1 
    BC015873.1 BT019670.1 CR541820.1 

    10 DOTS entries:

    DT.454070  DT.100789504  DT.100789507  DT.110932  DT.120943426  DT.92042333  DT.95375436  DT.100735469 
    DT.121612807  DT.91753140 

    Selected AceView cDNA sequences (see all 184):

    CR594242 AK027610 AW197633 BQ021574 AI149247 BF038506 AI225087 BQ434185 
    AA627917 CR602075 CB529180 BM794472 BC002973 BM782115 CR596638 AI889735 
    BM993674 BM770862 BU620415 AA972279 BM762437 AA974362 BM839989 BI518784 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNASEH1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                    -     -                             -           -                                       
    SP2:                          -                             -           -                                       
    SP3:                                                        -           -                                       
    SP4:                                                                                                            
    SP5:                    -                                                                                       


    ECgene alternative splicing isoforms for RNASEH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASEH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATACCAC
    RNASEH1 Expression
    About this image

    RNASEH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASEH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.568006

    UniProtKB/Swiss-Prot: RNH1_HUMAN, O60930
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNASEH1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnaseh11 , 5 ribonuclease H11, 5 78.71(n)1
    78.25(a)1
      12 (10.99 cM)5
    198191  NM_011275.31  NP_035405.21 
     286496025 
    chicken
    (Gallus gallus)
    Aves RNASEH11 ribonuclease H1 65.8(n)
    63.7(a)
      395848  NM_204998.1  NP_990329.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    50(a)
    1 → many
    GL343342.1(1104782-1123221)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU901570.12   -- 75.78(n)    BU901570.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.165222 Transcribed sequence with weak similarity to protein more 75.07(n)    BI980134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rnh11 , 3 ribonuclease H11, 3 35(a)3
    47.6(n)1
    40.91(a)1
      2 43F23
    357461  NM_206055.21  NP_995777.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rnh-1.01 rnh-1.0 54.11(n)
    46.32(a)
      3565940  NM_001047321.1  NP_001040786.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RNH1(YMR234W)4 Ribonuclease H1; able to bind double-stranded RNAs more   --   13(740266-741312) 855274  NP_013961.1 


    ENSEMBL Gene Tree for RNASEH1 (if available)
    TreeFam Gene Tree for RNASEH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNASEH1 gene
    ENSG000002557672  

    RNASEH1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RNASEH1
    PGOHUM00000236976 PGOHUM00000237240 PGOHUM00000245195


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNASEH1 (see all 318)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842297221,2
    C--3592246(+) ACAAAA/GGTTAT 1 -- ds50010--------
    rs792688641,2
    C--3592329(+) AAAAGG/ATTTAA 1 -- ds50014Minor allele frequency- A:0.13NA WA EA 360
    rs1473392981,2
    C--3592347(+) TAAATA/GATCAT 1 -- ds50010--------
    rs1887305101,2
    --3592363(+) ACTTTC/TACTAC 1 -- ds50010--------
    rs67459811,2
    C,F,A--3592450(+) acctcC/Tgccgc 1 -- ds5001 ese33Minor allele frequency- T:0.50NA WA CSA 6
    rs350450741,2
    C--3592692(+) TTTTT-/AAATTT 1 -- ut310--------
    rs709370411,2
    F--3592692(-) AAATTA/TAAAAA 1 -- ut311Minor allele frequency- T:0.12NA 42
    rs713970011,2
    C--3592693(+) TTTTA-/AATTTG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs67374191,2
    C,F,H--3592701(+) TTGCAC/TAGTTT 1 -- ut3111Minor allele frequency- T:0.06NS EA NA WA 1208
    rs1416631361,2
    C--3592725(+) CAAATA/GAATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RNASEH1 (3592383 - 3606206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNASEH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873590CNV Loss21882294
    nsv819972CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604123    OMIM disorders: --

    11 diseases for RNASEH1:    
    About MalaCards
    swine influenza    cartilage-hair hypoplasia    metaphyseal dysplasia    mitochondrial disorders
    influenza    ataxia telangiectasia    ataxia    hepatitis b
    hiv-1    malaria    hepatitis

    1 disease from the University of Copenhagen DISEASES database for RNASEH1:
    cartilage-hair hypoplasia

    RNASEH1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNASEH1
    Human Genome Epidemiology (HuGE) Navigator: RNASEH1 (1 document)

    Export disorders for RNASEH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNASEH1 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with RNASEH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Properties of cloned and expressed human RNase H1. (PubMed id 10497183)1, 2, 9 Wu H.... Crooke S.T. (J. Biol. Chem. 1999)
    2. Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. (PubMed id 17964265)1, 3, 9 Nowotny M....Yang W. (Mol. Cell 2007)
    3. Cloning, expression, and mapping of ribonucleases H of human and mouse related to bacterial RNase HI. (PubMed id 9799596)1, 2, 9 Cerritelli S.M. and Crouch R.J. (Genomics 1998)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome. (PubMed id 12036296)1, 3 ten Asbroek A.L....Baas F. (Genomics 2002)
    9. Cloning, subcellular localization and functional expression of human RNase HII. (PubMed id 9894807)1, 2 Frank P.... Holzmann K. (Biol. Chem. 1998)
    10. Molecular cloning and expression of cDNA for human RNase H. (PubMed id 9512096)1, 2 Wu H.... Crooke S.T. (Antisense Nucleic Acid Drug Dev. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 246243 HGNC: 18466 AceView: RNASEH1 Ensembl:ENSG00000171865 euGenes: HUgn246243
    ECgene: RNASEH1 Kegg: 246243 H-InvDB: RNASEH1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNASEH1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/RNase_H

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RNASEH1 gene:
    Search GeneIP for patents involving RNASEH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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