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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASEH1 Gene

protein-coding   GIFtS: 61
GCID: GC02M003592

Ribonuclease H1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease H11 2
RNase H11 2 3
Ribonuclease H Type II2 3
RNH12 3
H1RNA2
EC 3.1.26.43

External Ids:    HGNC: 184661   Entrez Gene: 2462432   Ensembl: ENSG000001718657   OMIM: 6041235   UniProtKB: O609303   

Export aliases for RNASEH1 gene to outside databases

Previous GC identifers: GC02M003070 GC02M003234 GC02M003157 GC02M003158 GC02M003085 GC02M003570 GC02M003535


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNASEH1 Gene: 
RNASEH1 (ribonuclease H1) is a protein-coding gene. Diseases associated with RNASEH1 include swine influenza, and cartilage-hair hypoplasia, and among its related super-pathways are Cell cycle Transition and termination of DNA replication and DNA strand elongation. GO annotations related to this gene include RNA binding and nucleic acid binding. An important paralog of this gene is ENSG00000255767.

UniProtKB/Swiss-Prot: RNH1_HUMAN, O60930
Function: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids

Gene Wiki entry for RNASEH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022139.13  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASEH1 gene promoter:
         GR   GR-beta   IRF-1   CUTL1   Evi-1   PPAR-gamma1   E2F-1   HOXA5   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASEH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASEH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASEH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25

RNASEH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASEH1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M003592:  view genomic region     (about GC identifiers)

Start:
3,592,383 bp from pter      End:
3,606,206 bp from pter
Size:
13,824 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNH1_HUMAN, O60930 (See protein sequence)
Recommended Name: Ribonuclease H1  
Size: 286 amino acids; 32064 Da
Cofactor: Binds 1 magnesium ion per subunit. May bind a second metal ion at a regulatory site, or after substrate
binding
Subunit: Monomer (Probable)
Subcellular location: Cytoplasm (Potential)
4 PDB 3D structures from and Proteopedia for RNASEH1:
2QK9 (3D)        2QKB (3D)        2QKK (3D)        3BSU (3D)    
Secondary accessions: B3KQU4 O60523 O60857 Q57Z93 Q5U0C1 Q6FHD4

Explore the universe of human proteins at neXtProt for RNASEH1: NX_O60930

Explore proteomics data for RNASEH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60930

  • RNASEH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNASEH1 Protein Expression
    REFSEQ proteins: NP_002927.2  
    ENSEMBL proteins: 
     ENSP00000404926   ENSP00000313350   ENSP00000411646  

    Human Recombinant Protein Products for RNASEH1: 
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    OriGene Protein Over-expression Lysate for RNASEH1
    OriGene MassSpec for RNASEH1 
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    GenScript Custom Purified and Recombinant Proteins Services for RNASEH1
    Novus Biologicals RNASEH1 Proteins
    Novus Biologicals RNASEH1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--

    RNASEH1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR009027 Ribosomal_L9/RNase_H1_N
     IPR017067 RNase_H1_euk
     IPR012337 RNaseH-like_dom
     IPR011320 RNase_H1_N
     IPR002156 RNaseH_domain

    Graphical View of Domain Structure for InterPro Entry O60930

    ProtoNet protein and cluster: O60930

    1 Blocks protein domain: IPB002156 RNase H

    UniProtKB/Swiss-Prot: RNH1_HUMAN, O60930
    Similarity: Belongs to the RNase H family
    Similarity: Contains 1 RNase H domain


    RNASEH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNH1_HUMAN, O60930
    Function: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids
    Catalytic activity: Endonucleolytic cleavage to 5'-phosphomonoester
    Enzyme regulation: In the presence of magnesium, manganese is inhibitory

         Genatlas biochemistry entry for RNASEH1:
    ribonuclease,RNAse H family,1,ubiquitously expressed,located in the SMCR critical region

         Enzyme Number (IUBMB): EC 3.1.26.41

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0003676nucleic acid binding TAS9799596
    GO:0003723RNA binding TAS9799596
    GO:0004523ribonuclease H activity IEA--
    GO:0004540ribonuclease activity TAS9799596
         
    RNASEH1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rnaseh1):
     cellular  embryogenesis  growth/size  mortality/aging 

    RNASEH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rnaseh1tm1Crh for RNASEH1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASEH1 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASEH1:
    hsa-miR-216a
    SwitchGear 3'UTR luciferase reporter plasmidRNASEH1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEH1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNASEH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95
    2Lagging Strand Synthesis
    DNA replication0.63

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RNASEH1
        Cell cycle Transition and termination of DNA replacation


    1 GeneGo (Thomson Reuters) Pathway for RNASEH1
        Cell cycle Transition and termination of DNA replication


    1         Kegg Pathway  (Kegg details for RNASEH1):
        DNA replication


    RNASEH1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASEH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for RNASEH1 (O609303 ENSP000003133504) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4IPQ5VYV73, ENSP000003355574I2D: score=1 STRING: ENSP00000335557
    RECQLENSP000003954494STRING: ENSP00000395449
    SSBP1ENSP000002653044STRING: ENSP00000265304
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    TM9SF1ENSP000002617894STRING: ENSP00000261789
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006264mitochondrial DNA replication IEA--
    GO:0006401RNA catabolic process TAS9799596

    RNASEH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNASEH1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASEH1 (RNH1)

    2 HMDB Compounds for RNASEH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    6 Novoseek inferred chemical compound relationships for RNASEH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxyribonucleotide 79.9 1 17028157 (1)
    oligoribonucleotide 69.6 1 14506260 (1)
    carboxylate 53.9 1 17226948 (1)
    ribose 44.7 2 8389211 (2)
    oligonucleotide 20 1 14500841 (1)
    alanine 3.92 2 12473655 (1), 14506260 (1)

    Search CenterWatch for drugs/clinical trials and news about RNASEH1 / RNH1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNASEH1 gene: 
    NM_002936.3  

    Unigene Cluster for RNASEH1:

    Ribonuclease H1
    Hs.568006  [show with all ESTs]
    Unigene Representative Sequence: AK027610
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436842(uc002qxs.3) ENST00000315212(uc002qxt.3) ENST00000464986
    ENST00000454734
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASEH1:
    hsa-miR-216a
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASEH1
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    Additional mRNA sequence: 

    AF039652.1 AF048994.1 AF048995.1 AJ224117.1 AK027610.1 AK075490.1 AK096913.1 BC002973.1 
    BC015873.1 BT019670.1 CR541820.1 

    10 DOTS entries:

    DT.454070  DT.100789504  DT.100789507  DT.110932  DT.120943426  DT.92042333  DT.95375436  DT.100735469 
    DT.121612807  DT.91753140 

    24/184 AceView cDNA sequences (see all 184):

    CA435275 BU620415 AA972279 AI279405 CR594242 CA775004 CB163780 AK027610 
    AA974362 BF223130 AI889735 AA627917 BU657200 BQ021574 AA883380 AI149247 
    CA771342 BQ434185 AI225087 BI518784 BM839989 BM782115 BC002973 BM794472 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RNASEH1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:                    -     -                             -           -                                       
    SP2:                          -                             -           -                                       
    SP3:                                                        -           -                                       
    SP4:                                                                                                            
    SP5:                    -                                                                                       


    ECgene alternative splicing isoforms for RNASEH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASEH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATATACCAC
    RNASEH1 Expression
    About this image


    See RNASEH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNASEH1

    SOURCE GeneReport for Unigene cluster: Hs.568006

    UniProtKB/Swiss-Prot: RNH1_HUMAN, O60930
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for RNASEH1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASEH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RNASEH1 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnaseh11 , 5 ribonuclease H11, 5 78.71(n)1
    78.25(a)1
      12 (10.99 cM)5
    198191  NM_011275.21  NP_035405.21 
     286496025 
    chicken
    (Gallus gallus)
    Aves RNASEH11 ribonuclease H1 66.28(n)
    64.12(a)
      395848  NM_204998.1  NP_990329.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    48(a)
    1 → many
    GL343342.1(1104782-1123221)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU901570.12   -- 75.78(n)    BU901570.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.165222 Transcribed sequence with weak similarity to protein more 75.07(n)    BI980134.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rnh11 , 3 ribonuclease H11, 3 35(a)3
    48.03(n)1
    42.52(a)1
      2 43F23
    357461  NM_057967.41  NP_477315.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rnh-1.01 Protein RNH-1.0 52.72(n)
    44.35(a)
      3565940  NM_001047321.1  NP_001040786.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RNH1(YMR234W)4
    RNH11
    Ribonuclease H1; able to bind double-stranded RNAs more4
    Rnh1p1
    48.86(n)1
    36.99(a)1
      13(740266-741312)4
    8552741, 4  NP_013961.11, 4 


    ENSEMBL Gene Tree for RNASEH1 (if available)
    TreeFam Gene Tree for RNASEH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNASEH1 gene
    ENSG000002557672  

    RNASEH1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for RNASEH1
    PGOHUM00000236976 PGOHUM00000237240 PGOHUM00000245195


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/318 SNPs in RNASEH1 are shown (see all 318)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0234694
    ----see VAR_0234692 L F mis40--------
    rs1842297221,2
    C--3592246(+) ACAAAA/GGTTAT 1 -- ds50010--------
    rs792688641,2
    C--3592329(+) AAAAGG/ATTTAA 1 -- ds50014Minor allele frequency- A:0.13NA WA EA 360
    rs1473392981,2
    C--3592347(+) TAAATA/GATCAT 1 -- ds50010--------
    rs1887305101,2
    --3592363(+) ACTTTC/TACTAC 1 -- ds50010--------
    rs67459811,2
    C,F,A--3592450(+) acctcC/Tgccgc 1 -- ds5001 ese33Minor allele frequency- T:0.50NA WA CSA 6
    rs350450741,2
    C--3592692(+) TTTTT-/AAATTT 1 -- ut310--------
    rs709370411,2
    F--3592692(-) AAATTA/TAAAAA 1 -- ut311Minor allele frequency- T:0.12NA 42
    rs713970011,2
    C--3592693(+) TTTTA-/AATTTG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs67374191,2
    C,F,H--3592701(+) TTGCAC/TAGTTT 1 -- ut3111Minor allele frequency- T:0.06NS EA NA WA 1208

    HapMap Linkage Disequilibrium report for RNASEH1 (3592383 - 3606206 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNASEH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873590CNV Loss21882294
    nsv819972CNV Gain19587683

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604123    OMIM disorders: --

    9 diseases for RNASEH1:    About MalaCards
    swine influenza    cartilage-hair hypoplasia    metaphyseal dysplasia    mitochondrial disorders
    influenza    ataxia telangiectasia    ataxia    hepatitis b
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for RNASEH1:
    cartilage-hair hypoplasia

    RNASEH1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNASEH1
    Human Genome Epidemiology (HuGE) Navigator: RNASEH1 (1 document)

    Export disorders for RNASEH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASEH1 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with RNASEH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Properties of cloned and expressed human RNase H1. (PubMed id 10497183)1, 2, 9 Wu H.... Crooke S.T. (1999)
    2. Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. (PubMed id 17964265)1, 3, 9 Nowotny M....Yang W. (2007)
    3. Cloning, expression, and mapping of ribonucleases H of human and mouse related to bacterial RNase HI. (PubMed id 9799596)1, 2, 9 Cerritelli S.M. and Crouch R.J. (1998)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Ribonuclease H1 maps to chromosome 2 and has at least three pseudogene loci in the human genome. (PubMed id 12036296)1, 3 ten Asbroek A.L....Baas F. (2002)
    9. Cloning, subcellular localization and functional expression of human RNase HII. (PubMed id 9894807)1, 2 Frank P....Holzmann K. (1998)
    10. Molecular cloning and expression of cDNA for human RNase H. (PubMed id 9512096)1, 2 Wu H.... Crooke S.T. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 246243 HGNC: 18466 AceView: RNASEH1 Ensembl:ENSG00000171865 euGenes: HUgn246243
    ECgene: RNASEH1 Kegg: 246243 H-InvDB: RNASEH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNASEH1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/RNase_H

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNASEH1 gene:
    Search GeneIP for patents involving RNASEH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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