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Aliases for RNASE9 Gene

Aliases for RNASE9 Gene

  • Ribonuclease A Family Member 9 (Inactive) 2 3 5
  • Ribonuclease, RNase A Family, 9 (Non-Active) 2 3
  • Inactive Ribonuclease-Like Protein 9 3
  • Ribonuclear Enzyme 3
  • Ribonuclease A K1 3
  • HEL128 3
  • RAK1 3
  • H461 3

External Ids for RNASE9 Gene

Previous GeneCards Identifiers for RNASE9 Gene

  • GC14M020096
  • GC14M021024
  • GC14M001145

Summaries for RNASE9 Gene

GeneCards Summary for RNASE9 Gene

RNASE9 (Ribonuclease A Family Member 9 (Inactive)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity.

UniProtKB/Swiss-Prot for RNASE9 Gene

  • Does not exhibit any ribonuclease activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE9 Gene

Genomics for RNASE9 Gene

Regulatory Elements for RNASE9 Gene

Enhancers for RNASE9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020453 1.2 ENCODE 16.3 +105.4 105389 3.9 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 OSGEP SUPT16H ENSG00000258515 APEX1 TMEM55B TEP1 RNASE9 RNASE12 LOC105370394 OR11G2
GH14F020530 1.1 Ensembl ENCODE 16.4 +29.8 29831 0.6 NFXL1 YBX1 ZNF2 RAD21 ZNF366 GATA2 ETV6 FOS ZNF654 SP3 RNASE9 RNASE12 LOC105370394 OR11G2 CKAP2P1 OR11K2P OR4H12P OR4N2 OR4K6P OR4Q3
GH14F020601 0.9 Ensembl 11.6 -40.9 -40870 0.4 ARID4B SIN3A DNMT3B ZNF48 RARA ZNF335 THAP11 ZNF263 HMG20B SP3 RNASE9 RNA5SP382 TEP1 SNORD126 CCNB1IP1 TRP-AGG2-5 RNASE12
GH14F020605 0.9 ENCODE 11.6 -45.5 -45499 1.2 ELF3 RAD21 RARA ZNF143 MIXL1 HMG20B ZNF654 MIER2 REST KAT8 RNASE9 TEP1 RNA5SP382 SNORD126 CCNB1IP1 TRP-AGG2-5 RNASE12
GH14F020591 0.5 FANTOM5 7.5 -30.9 -30941 0.1 ZFHX2 IKZF1 EGR2 OR4K17 OR6S1 RNASE12 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASE9 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE9 Gene

Chromosome:
14
Start:
20,556,093 bp from pter
End:
20,560,931 bp from pter
Size:
4,839 bases
Orientation:
Minus strand

Genomic View for RNASE9 Gene

Genes around RNASE9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE9 Gene

Proteins for RNASE9 Gene

  • Protein details for RNASE9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60153-RNAS9_HUMAN
    Recommended name:
    Inactive ribonuclease-like protein 9
    Protein Accession:
    P60153
    Secondary Accessions:
    • A2RQR8
    • A8QJS1
    • Q5GAN7
    • Q6KG53

    Protein attributes for RNASE9 Gene

    Size:
    205 amino acids
    Molecular mass:
    24307 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNASE9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASE9 Gene

Post-translational modifications for RNASE9 Gene

  • Glycosylation at Asn 131 and Asn 143
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNASE9 Gene

Domains & Families for RNASE9 Gene

Gene Families for RNASE9 Gene

Protein Domains for RNASE9 Gene

Graphical View of Domain Structure for InterPro Entry

P60153

UniProtKB/Swiss-Prot:

RNAS9_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE9: view

Function for RNASE9 Gene

Molecular function for RNASE9 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Gene Ontology (GO) - Molecular Function for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 NOT endonuclease activity IBA --
GO:0004540 NOT ribonuclease activity IKR 15676279
genes like me logo Genes that share ontologies with RNASE9: view
genes like me logo Genes that share phenotypes with RNASE9: view

Animal Models for RNASE9 Gene

MGI Knock Outs for RNASE9:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE9 Gene

Localization for RNASE9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE9 gene
Compartment Confidence
extracellular 4
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE9: view

Pathways & Interactions for RNASE9 Gene

SuperPathways for RNASE9 Gene

No Data Available

Interacting Proteins for RNASE9 Gene

Selected Interacting proteins: P60153-RNAS9_HUMAN for RNASE9 Gene via IID

Symbol External ID(s) Details
TPST2

Gene Ontology (GO) - Biological Process for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060474 positive regulation of flagellated sperm motility involved in capacitation IEA --
genes like me logo Genes that share ontologies with RNASE9: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE9 Gene

Transcripts for RNASE9 Gene

mRNA/cDNA for RNASE9 Gene

(8) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE9 Gene

No ASD Table

Relevant External Links for RNASE9 Gene

GeneLoc Exon Structure for
RNASE9
ECgene alternative splicing isoforms for
RNASE9

Expression for RNASE9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE9 Gene

Protein differential expression in normal tissues from HIPED for RNASE9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE9 Gene



Protein tissue co-expression partners for RNASE9 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE9 Gene:

RNASE9

SOURCE GeneReport for Unigene cluster for RNASE9 Gene:

Hs.533972

mRNA Expression by UniProt/SwissProt for RNASE9 Gene:

P60153-RNAS9_HUMAN
Tissue specificity: At the mRNA level, widely expressed (PubMed:18992174). At protein level, restricted to epididymis (PubMed:19137000). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle.
genes like me logo Genes that share expression patterns with RNASE9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNASE9 Gene

Orthologs for RNASE9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE9 34 35
  • 97.4 (n)
rat
(Rattus norvegicus)
Mammalia Rnase9 34
  • 56.43 (n)
mouse
(Mus musculus)
Mammalia Rnase9 34 16 35
  • 55.95 (n)
dog
(Canis familiaris)
Mammalia RNASE9 35
  • 45 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNASE9 35
  • 41 (a)
OneToOne
Species where no ortholog for RNASE9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE9 Gene

ENSEMBL:
Gene Tree for RNASE9 (if available)
TreeFam:
Gene Tree for RNASE9 (if available)

Paralogs for RNASE9 Gene

No data available for Paralogs for RNASE9 Gene

Variants for RNASE9 Gene

Sequence variations from dbSNP and Humsavar for RNASE9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10145245 -- 20,559,384(+) ATGGG(A/G)ATTAA intron-variant
rs111600594 -- 20,556,605(+) GATTC(A/G)TATTT reference, synonymous-codon
rs111738679 -- 20,557,044(+) GTGGG(G/T)GTGTG reference, missense
rs111769658 -- 20,555,984(+) ATGTA(C/T)TGCAT downstream-variant-500B
rs111918113 -- 20,558,718(+) TTTCT(A/T)CTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE9 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for RNASE9 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE9 Gene

Disorders for RNASE9 Gene

Relevant External Links for RNASE9

Genetic Association Database (GAD)
RNASE9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE9

No disorders were found for RNASE9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE9 Gene

Publications for RNASE9 Gene

  1. Cloning, expression and location of RNase9 in human epididymis. (PMID: 18992174) Liu J. … Wang W. (BMC Res. Notes 2008) 3 4 22 64
  2. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 2 3 4 64
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3 46 64
  4. Human ribonuclease 9, a member of ribonuclease A superfamily, specifically expressed in epididymis, is a novel sperm-binding protein. (PMID: 19137000) Cheng G.Z. … Shi G.X. (Asian J. Androl. 2009) 4 22 64
  5. Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PMID: 12920233) Penttinen J. … Poutanen M. (Mol. Endocrinol. 2003) 2 3 64

Products for RNASE9 Gene

Sources for RNASE9 Gene

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