RNASE9 Gene
protein-coding GIFtS: 40
GCID: GC14M021024
|
|
ribonuclease, RNase A family, 9 (non-active)
| |
Aliases
for RNASE9 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribonuclease, RNase A Family, 9 (Non-Active)1 2 | | Ribonuclear Enzyme2 | | H4611 | | Ribonuclease 92 | | HEL1282 | | Ribonuclease-Like Protein 92 | | Inactive Ribonuclease-Like Protein 92 | | |
Export aliases for RNASE9 gene to outside databasesPrevious GC identifers: GC14M020096 GC14M001145 |
Summaries
for RNASE9 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RNAS9_HUMAN, P60153Function: Does not exhibit any ribonuclease activity
|
Genomic Views
for RNASE9 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNASE9 gene promoter:
NF-YA CBF-C POU2F1 CBF-B POU2F1b POU2F1a POU2F1c CP1A CP1C NF-Y
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNASE9
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE9 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2RNASE9 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M021024: view genomic region
(about GC identifiers)
Start:
|
21,024,252 bp from pter |
End:
|
21,029,090 bp from pter |
Size:
|
4,839 bases |
Orientation:
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minus strand |
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Proteins
for RNASE9 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNAS9_HUMAN, P60153 (See
protein sequence)Recommended Name: Inactive ribonuclease-like protein 9 precursor Size: 205 amino acids; 24307 Da
Subcellular location: Secreted (Probable)
Secondary accessions: A2RQR8 A8QJS1 Q5GAN7 Q6KG53Alternative splicing: 2 isoforms: P60153-1 P60153-2 Explore the universe of human proteins at neXtProt for RNASE9: NX_P60153
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P60153
RNASE9 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001001673.2 NP_001103826.1 NP_001103827.1 NP_001103828.1 NP_001103829.1 NP_001103830.1 NP_001103831.1
ENSEMBL proteins: ENSP00000340162 ENSP00000450599 ENSP00000450800 ENSP00000451565 ENSP00000384683 ENSP00000451160 ENSP00000451285 ENSP00000409504 ENSP00000450570 ENSP00000450987
Human Recombinant Protein Products for RNASE9:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
RNASE9 for ontologies About GeneDecksing
RNASE9 Antibody Products:
Assay Products for RNASE9: |
Protein
Domains /
Families
for RNASE9 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNASE9 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P60153ProtoNet protein and cluster: P60153 UniProtKB/Swiss-Prot: RNAS9_HUMAN, P60153Similarity: Belongs to the pancreatic ribonuclease family |
Function
for RNASE9 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: RNAS9_HUMAN, P60153Function: Does not exhibit any ribonuclease activity Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0004522 | pancreatic ribonuclease activity |
IEA | -- |
RNASE9 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE9 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE9 (see all 7)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 7): RNASE9 (NM_001110361) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE9 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE9 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE9 |
|
Pathways & Interactions
for RNASE9 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE9
|
Drugs & Compounds
for RNASE9 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNASE9
Search CenterWatch for drugs/clinical trials and news about RNASE9 / RNAS9
|
Transcripts
for RNASE9 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNASE9 gene (7 alternative transcripts): NM_001001673.3 NM_001110356.1 NM_001110357.1 NM_001110358.1 NM_001110359.1 NM_001110360.1 NM_001110361.1 Unigene Cluster for RNASE9: Ribonuclease, RNase A family, 9 (non-active) Hs.533972 Unigene Representative Sequence: EF06130210 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338904(uc010ahu.3) ENST00000554964(uc010ahs.3) ENST00000555230
ENST00000557068 ENST00000404716(uc010ahp.3) ENST00000556208(uc010ahq.3)
ENST00000553541(uc010aho.3) ENST00000429244(uc010aht.3) ENST00000553706(uc001vxq.4)
ENST00000557209(uc010ahr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE9 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE9 (see all 7)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 7): RNASE9 (NM_001110361) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE9 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE9 |
Additional cDNA sequence: AF382949.1 AY665804.1 AY907670.1 BC130311.1 BC130313.1 EF061296.1 EF061297.1 EF061298.1 EF061299.1 EF061300.1 EF061301.1 EF061302.1 EU414264.1 2 DOTS entries: DT.102831376 DT.120767661 2 AceView cDNA sequences: NM_001001673 AF382949
GeneLoc Exon Structure
|
Expression
for RNASE9 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNASE9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTGAATGT
About this image
See RNASE9 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.533972
UniProtKB/Swiss-Prot: RNAS9_HUMAN, P60153Tissue specificity: At the mRNA level, widely expressed (PubMed:18992174). At protein level, restricted to epididymis(PubMed:19137000). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymalsperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (atprotein level). Not detected in muscle
SABiosciences Custom PCR Arrays for RNASE9
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE9
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASE9 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE9 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE9 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE9 |
Orthologs
for RNASE9 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for RNASE9 gene from 1/3 species (see all 3) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rnase91 , 5 |
ribonuclease, RNase A family, 9 (non-active)1, 5 |
56.26(n)1
37.57(a)1 |
|
14 (26.35 cM)5
3284011 NM_183032.21 NP_898853.21
510384595 |
ENSEMBL Gene Tree for RNASE9 (if available)
TreeFam Gene Tree for RNASE9 (if available) |
Paralogs
for RNASE9 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RNASE9 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNASE9 (21024252 - 21029090 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNASE9
1 CNV: 71865 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE9 |
|
Disorders
/ Diseases
for RNASE9 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNASE9 for disorders About GeneDecksing
OMIM gene information: 614014
OMIM disorders: --
2  diseases for RNASE9: About MalaCardsepididymitis pancreatitis
Export disorders for RNASE9 gene to outside databases
|
Publications
for RNASE9 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNASE9 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNASE9) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1, 2, 3 Cho S.... Zhang J. (2005)
- Cloning, expression and location of RNase9 in human epididymis. (PubMed id 18992174)1, 2, 9 Liu J....Wang W. (2008)
- Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PubMed id 12920233)1, 3 Penttinen J....Poutanen M. (2003)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Human ribonuclease 9, a member of ribonuclease A superfamily, specifically expressed in epididymis, is a novel sperm-binding protein. (PubMed id 19137000)2, 9 Cheng G.Z....Shi G.X. (2009)
- A genome-wide search for loci interacting with known p rostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- LOC 390443 (RNase 9) on chromosome 14q11.2 is related to the RNase A superfamily and contains a unique amino-terminal preproteinlike sequence. (PubMed id 15974301)1 Devor E.J....Galbraith J.J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RNASE9 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNASE9 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNASE9 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNASE9 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNASE9 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNASE9 gene:
Search GeneIP for patents involving RNASE9
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNASE9 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNASE9 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE9 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE9 | | | OriGene Protein Over-expression Lysate for RNASE9 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNASE9 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE9 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE9 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 | | | RNASE9 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE9 |
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