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Aliases for RNASE9 Gene

Aliases for RNASE9 Gene

  • Ribonuclease, RNase A Family, 9 (Non-Active) 2 3
  • Inactive Ribonuclease-Like Protein 9 3
  • Ribonuclear Enzyme 3
  • Ribonuclease A K1 3
  • HEL128 3
  • RNAE9 6
  • RAK1 3
  • H461 3

External Ids for RNASE9 Gene

Previous GeneCards Identifiers for RNASE9 Gene

  • GC14M020096
  • GC14M021024
  • GC14M001145

Summaries for RNASE9 Gene

GeneCards Summary for RNASE9 Gene

RNASE9 (Ribonuclease, RNase A Family, 9 (Non-Active)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease A activity.

UniProtKB/Swiss-Prot for RNASE9 Gene

  • Does not exhibit any ribonuclease activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE9 Gene

Genomics for RNASE9 Gene

Regulatory Elements for RNASE9 Gene

Genomic Location for RNASE9 Gene

Start:
20,556,093 bp from pter
End:
20,560,966 bp from pter
Size:
4,874 bases
Orientation:
Minus strand

Genomic View for RNASE9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE9 Gene

Proteins for RNASE9 Gene

  • Protein details for RNASE9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60153-RNAS9_HUMAN
    Recommended name:
    Inactive ribonuclease-like protein 9
    Protein Accession:
    P60153
    Secondary Accessions:
    • A2RQR8
    • A8QJS1
    • Q5GAN7
    • Q6KG53

    Protein attributes for RNASE9 Gene

    Size:
    205 amino acids
    Molecular mass:
    24307 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNASE9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASE9 Gene

Proteomics data for RNASE9 Gene at MOPED

Post-translational modifications for RNASE9 Gene

  • Glycosylation at Asn131 and Asn143
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RNASE9 Gene

Domains for RNASE9 Gene

Gene Families for RNASE9 Gene

HGNC:
  • RNASE :Ribonucleases, RNase A

Protein Domains for RNASE9 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P60153

UniProtKB/Swiss-Prot:

RNAS9_HUMAN :
  • P60153
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE9: view

Function for RNASE9 Gene

Molecular function for RNASE9 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Gene Ontology (GO) - Molecular Function for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity IBA --
genes like me logo Genes that share ontologies with RNASE9: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNASE9 Gene

Localization for RNASE9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE9 Gene COMPARTMENTS Subcellular localization image for RNASE9 gene
Compartment Confidence
extracellular 4
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE9: view

Pathways for RNASE9 Gene

SuperPathways for RNASE9 Gene

No Data Available

Interacting Proteins for RNASE9 Gene

Gene Ontology (GO) - Biological Process for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IBA --
GO:0090501 RNA phosphodiester bond hydrolysis IBA --
genes like me logo Genes that share ontologies with RNASE9: view

No data available for Pathways by source for RNASE9 Gene

Transcripts for RNASE9 Gene

mRNA/cDNA for RNASE9 Gene

(2) Selected AceView cDNA sequences:
(8) REFSEQ mRNAs :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE9 Gene

No ASD Table

Relevant External Links for RNASE9 Gene

GeneLoc Exon Structure for
RNASE9
ECgene alternative splicing isoforms for
RNASE9

Expression for RNASE9 Gene

mRNA expression in normal human tissues for RNASE9 Gene

Protein differential expression in normal tissues for RNASE9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RNASE9 Gene

SOURCE GeneReport for Unigene cluster for RNASE9 Gene Hs.533972

mRNA Expression by UniProt/SwissProt for RNASE9 Gene

P60153-RNAS9_HUMAN
Tissue specificity: At the mRNA level, widely expressed (PubMed:18992174). At protein level, restricted to epididymis (PubMed:19137000). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle.
genes like me logo Genes that share expressions with RNASE9: view

Expression partners for RNASE9 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNASE9 Gene

Orthologs for RNASE9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE9 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Rnase9 35
  • 55.95 (n)
  • 36.43 (a)
Rnase9 16
Rnase9 36
  • 36 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNASE9 35
  • 97.4 (n)
  • 95.12 (a)
RNASE9 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnase9 35
  • 56.43 (n)
  • 40.71 (a)
cow
(Bos Taurus)
Mammalia RNASE9 36
  • 41 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNASE9 36
  • 45 (a)
OneToOne
Species with no ortholog for RNASE9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE9 Gene

ENSEMBL:
Gene Tree for RNASE9 (if available)
TreeFam:
Gene Tree for RNASE9 (if available)

Paralogs for RNASE9 Gene

No data available for Paralogs for RNASE9 Gene

Variants for RNASE9 Gene

Sequence variations from dbSNP and Humsavar for RNASE9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs731897 -- 20,558,133(+) CATGA(A/G)GAACC intron-variant, utr-variant-5-prime
rs744918 -- 20,558,143(+) CAATT(A/G)TTTAA intron-variant, utr-variant-5-prime
rs891297 -- 20,558,614(-) TGAGA(A/G)TATGT intron-variant, splice-donor-variant, utr-variant-5-prime
rs891298 -- 20,558,212(-) GCCAC(C/G)AAGTA intron-variant, utr-variant-5-prime
rs1243642 -- 20,562,688(-) TCAAG(C/T)CTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE9 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
nsv901468 CNV Gain 21882294

Relevant External Links for RNASE9 Gene

HapMap Linkage Disequilibrium report
RNASE9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE9 Gene

Disorders for RNASE9 Gene

Relevant External Links for RNASE9

Genetic Association Database (GAD)
RNASE9

No disorders were found for RNASE9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RNASE9 Gene

Publications for RNASE9 Gene

  1. Cloning, expression and location of RNase9 in human epididymis. (PMID: 18992174) Liu J. … Wang W. (BMC Res. Notes 2008) 3 4 23
  2. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 2 3 4
  3. Human ribonuclease 9, a member of ribonuclease A superfamily, specifically expressed in epididymis, is a novel sperm-binding protein. (PMID: 19137000) Cheng G.Z. … Shi G.X. (Asian J. Androl. 2009) 4 23
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  5. Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PMID: 12920233) Penttinen J. … Poutanen M. (Mol. Endocrinol. 2003) 2 3

Products for RNASE9 Gene

Sources for RNASE9 Gene

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