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Aliases for RNASE9 Gene

Aliases for RNASE9 Gene

  • Ribonuclease A Family Member 9 (Inactive) 2 3
  • Ribonuclease, RNase A Family, 9 (Non-Active) 2 3 5
  • Ribonuclear Enzyme 3
  • Ribonuclease A K1 3
  • HEL128 3
  • RAK1 3
  • H461 3

External Ids for RNASE9 Gene

Previous GeneCards Identifiers for RNASE9 Gene

  • GC14M020096
  • GC14M021024
  • GC14M001145

Summaries for RNASE9 Gene

GeneCards Summary for RNASE9 Gene

RNASE9 (Ribonuclease A Family Member 9 (Inactive)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity.

UniProtKB/Swiss-Prot for RNASE9 Gene

  • Does not exhibit any ribonuclease activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE9 Gene

Genomics for RNASE9 Gene

Regulatory Elements for RNASE9 Gene

Enhancers for RNASE9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNASE9 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE9 Gene

20,556,093 bp from pter
20,560,931 bp from pter
4,839 bases
Minus strand

Genomic View for RNASE9 Gene

Genes around RNASE9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE9 Gene

Proteins for RNASE9 Gene

  • Protein details for RNASE9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive ribonuclease-like protein 9
    Protein Accession:
    Secondary Accessions:
    • A2RQR8
    • A8QJS1
    • Q5GAN7
    • Q6KG53

    Protein attributes for RNASE9 Gene

    205 amino acids
    Molecular mass:
    24307 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNASE9 Gene


neXtProt entry for RNASE9 Gene

Proteomics data for RNASE9 Gene at MOPED

Post-translational modifications for RNASE9 Gene

  • Glycosylation at Asn 131 and Asn 143
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNASE9 Gene

Domains & Families for RNASE9 Gene

Gene Families for RNASE9 Gene

Protein Domains for RNASE9 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE9: view

Function for RNASE9 Gene

Molecular function for RNASE9 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Gene Ontology (GO) - Molecular Function for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RNASE9: view
genes like me logo Genes that share phenotypes with RNASE9: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE9 Gene

Localization for RNASE9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE9 Gene


Subcellular locations from

Jensen Localization Image for RNASE9 Gene COMPARTMENTS Subcellular localization image for RNASE9 gene
Compartment Confidence
extracellular 4
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for RNASE9 Gene

Pathways & Interactions for RNASE9 Gene

SuperPathways for RNASE9 Gene

No Data Available

Interacting Proteins for RNASE9 Gene

Gene Ontology (GO) - Biological Process for RNASE9 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNASE9 Gene

Drugs & Compounds for RNASE9 Gene

No Compound Related Data Available

Transcripts for RNASE9 Gene

mRNA/cDNA for RNASE9 Gene

(8) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE9 Gene

No ASD Table

Relevant External Links for RNASE9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE9 Gene

mRNA expression in normal human tissues for RNASE9 Gene

Protein differential expression in normal tissues from HIPED for RNASE9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE9 Gene

SOURCE GeneReport for Unigene cluster for RNASE9 Gene Hs.533972

mRNA Expression by UniProt/SwissProt for RNASE9 Gene

Tissue specificity: At the mRNA level, widely expressed (PubMed:18992174). At protein level, restricted to epididymis (PubMed:19137000). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle.
genes like me logo Genes that share expression patterns with RNASE9: view

Protein tissue co-expression partners for RNASE9 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RNASE9 Gene

Orthologs for RNASE9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE9 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Rnase9 35
  • 55.95 (n)
  • 36.43 (a)
Rnase9 16
Rnase9 36
  • 36 (a)
(Pan troglodytes)
Mammalia RNASE9 35
  • 97.4 (n)
  • 95.12 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Rnase9 35
  • 56.43 (n)
  • 40.71 (a)
(Bos Taurus)
Mammalia RNASE9 36
  • 41 (a)
(Canis familiaris)
Mammalia RNASE9 36
  • 45 (a)
Species with no ortholog for RNASE9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE9 Gene

Gene Tree for RNASE9 (if available)
Gene Tree for RNASE9 (if available)

Paralogs for RNASE9 Gene

No data available for Paralogs for RNASE9 Gene

Variants for RNASE9 Gene

Sequence variations from dbSNP and Humsavar for RNASE9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1243647 - 20,556,460(-) TCATA(C/T)CGCCC reference, missense
rs12590446 - 20,556,627(+) TTTCA(A/G)ATGCT reference, missense
rs731897 -- 20,558,133(+) CATGA(A/G)GAACC intron-variant
rs744918 -- 20,558,143(+) CAATT(A/G)TTTAA intron-variant
rs8006448 -- 20,562,791(+) ACCAA(A/T)TATAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE9 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
nsv901468 CNV Gain 21882294

Variation tolerance for RNASE9 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNASE9 Gene

Disorders for RNASE9 Gene

Relevant External Links for RNASE9

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNASE9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE9 Gene

Publications for RNASE9 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 2 3 4 67
  2. Cloning, expression and location of RNase9 in human epididymis. (PMID: 18992174) Liu J. … Wang W. (BMC Res. Notes 2008) 3 23
  3. Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PMID: 12920233) Penttinen J. … Poutanen M. (Mol. Endocrinol. 2003) 2 3
  4. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3
  5. Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. (PMID: 24811271) Kennedy R.B. … Poland G.A. (Immunogenetics 2014) 3

Products for RNASE9 Gene

Sources for RNASE9 Gene