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RNASE8 Gene

protein-coding   GIFtS: 42
GCID: GC14P021525

Ribonuclease, RNase A Family, 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease, RNase A Family, 81 2     RNase 83
Ribonuclease 82     EC 3.1.278
RNase 8, Placental2     EC 3.1.27.58
EC 3.1.27.-3     

External Ids:    HGNC: 192771   Entrez Gene: 1226652   Ensembl: ENSG000001734317   OMIM: 6124855   UniProtKB: Q8TDE33   

Export aliases for RNASE8 gene to outside databases

Previous GC identifers: GC14P018898 GC14P015313 GC14P019516 GC14P020595 GC14P001647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNASE8 Gene:
RNASE8 (ribonuclease, RNase A family, 8) is a protein-coding gene. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3
Function: Has a low ribonuclease activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE8 gene promoter:
         TBP   AML1a   Brachyury   MyoD   PPAR-alpha   c-Rel   FOXJ2 (long isoform)   FOXJ2   MRF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE8 promoter sequence
   Search Chromatin IP Primers for RNASE8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RNASE8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021525:  view genomic region     (about GC identifiers)

Start:
21,525,981 bp from pter      End:
21,526,614 bp from pter
Size:
634 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3 (See protein sequence)
Recommended Name: Ribonuclease 8 precursor  
Size: 154 amino acids; 17041 Da
Secondary accessions: B2RPP6 B2RPP7

Explore the universe of human proteins at neXtProt for RNASE8: NX_Q8TDE3

Explore proteomics data for RNASE8 at MOPED

Selected DME Specific Peptides for RNASE8 (Q8TDE3) (see all 5)
 TCQTPNI  LVPVHLD  CKDLNTFLH  LLLLLLGLWVA 


See RNASE8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_612204.1  
ENSEMBL proteins: 
 ENSP00000311398  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RNASE: Ribonucleases, RNase A

3 InterPro protein domains:
 IPR023411 RNaseA_AS
 IPR023412 RNaseA_domain
 IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry Q8TDE3

ProtoNet protein and cluster: Q8TDE3

1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3
Similarity: Belongs to the pancreatic ribonuclease family


Find genes that share domains with RNASE8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RNAS8_HUMAN, Q8TDE3
Function: Has a low ribonuclease activity

     Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0004522pancreatic ribonuclease activity IDA11861908
     
Find genes that share ontologies with RNASE8           About GenesLikeMe


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RNAS8_HUMAN, Q8TDE3: Secreted (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular4
nucleus1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with RNASE8           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASE8
Interactions:

    Search GeneGlobe Interaction Network for RNASE8

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic IDA11861908

Find genes that share ontologies with RNASE8           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for RNASE8 (RNAS8)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RNASE8 gene: 
NM_138331.1  

Unigene Cluster for RNASE8:

Ribonuclease, RNase A family, 8
Hs.553572
Unigene Representative Sequence: JQ353679
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000308227(uc010tlm.2)
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Additional mRNA sequence: 

BC137537.1 BC137538.1 JQ353679.1 

1 AceView cDNA sequence:

NM_138331 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNASE8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTGAGCTCA
RNASE8 Expression
About this image

RNASE8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RNASE8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.553572

UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3
Tissue specificity: Expressed prominently in the placenta and is not detected in any other tissues examined

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RNASE8 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
Uncharacterized protein
58(a)
1 → many
1(169623910-169624371)
chicken
(Gallus gallus)
Aves ANG6
CL26
(see all 3)
Gallus gallus liver ribonuclease A (CL2), mRNA.
(see all 3)
27(a)
26(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
6(8796401-8797835)
4(49041665-49042706)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
24(a)
21(a)
many ↔ many
many ↔ many
GL343220.1(1531632-1532063)
GL343220.1(1279015-1279452)


ENSEMBL Gene Tree for RNASE8 (if available)
TreeFam Gene Tree for RNASE8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RNASE8 gene
RNASE32  RNASE72  RNASE22  RNASE12  ANG2  RNASE62  RNASE42  
6 SIMAP similar genes for RNASE8 using alignment to 7 protein entries:     RNAS8_HUMAN (see all proteins):
RNASE7    RNASE6    RNASE2    ECRP    RNASE3    RNASE1

Find genes that share paralogs with RNASE8           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RNASE8 (see all 88)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1928272311,2
--21524057(+) TGTTCC/TCTGCT 1 -- us2k10--------
rs743206891,2
F--21524063(+) CTGCTG/ACCCAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1508109441,2
C--21524167(+) GAAAAC/GGTGAG 1 -- us2k10--------
rs800839231,2
C,F--21524215(+) TGAGAT/GGACAA 1 -- us2k11Minor allele frequency- G:0.03WA 118
rs777092951,2
C,F--21524218(+) GATGAC/TAAACA 1 -- us2k13Minor allele frequency- T:0.05WA NA EA 358
rs101339681,2
C,F,A,H--21524270(+) TCGGCG/AAATTT 1 -- us2k123Minor allele frequency- A:0.19NS EA NA WA CSA 2351
rs1853086911,2
--21524304(+) CCCAAA/CGGTGG 1 -- us2k10--------
rs1145663451,2
F--21524475(+) TAATAC/TGCTAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
rs751356761,2
F--21524476(+) AATACA/GCTAAA 1 -- us2k10--------
rs1875303591,2
--21524556(+) TACTAA/GTGTTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RNASE8 (21525981 - 21526614 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RNASE8:    About this table    
Variant IDTypeSubtypePubMed ID
nsv832740CNV Gain17160897
nsv826882CNV Gain20364138
nsv428293CNV Gain+Loss18775914

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612485    OMIM disorders: --


Find genes that share disorders with RNASE8           About GenesLikeMe


Export disorders for RNASE8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RNASE8 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RNASE8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. (PubMed id 11861908)1, 2, 3, 9 Zhang J.... Rosenberg H.F. (Nucleic Acids Res. 2002)
  2. Disulfide-bond reshuffling in the evolution of an ape placental ribonuclease. (PubMed id 17116644)1, 9 Zhang J. (Mol. Biol. Evol. 2007)
  3. Genetic diversity of human RNase 8. (PubMed id 22272736)1 Chan C.C.... Rosenberg H.F. (BMC Genomics 2012)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  6. Identification of RNase 8 as a novel human antimicrobial protein. (PubMed id 16940129)9 Rudolph B....Harder J. (Antimicrob. Agents Chemother. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 122665 HGNC: 19277 AceView: RNASE8 Ensembl:ENSG00000173431 euGenes: HUgn122665
ECgene: RNASE8 H-InvDB: RNASE8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RNASE8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RNASE8 gene:
Search GeneIP for patents involving RNASE8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 Browse ESI BIO Cell Lines and PureStem Progenitors for RNASE8
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE8
 Browse SwitchGear 3'UTR luciferase reporter plasmids for RNASE8
 SwitchGear Promoter luciferase reporter plasmids for RNASE8
 Search ThermoFisher Antibodies for RNASE8
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE8
 Browse compounds at ApexBio
 Search Addgene for plasmids for RNASE8
  Search eBioscience for proteins for RNASE8
  Search eBioscience for elisas for RNASE8
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for RNASE8
 antibodies-online antibodies for RNASE8 (13 products)
 antibodies-online kits for RNASE8 (4 products)
 antibodies-online peptides for RNASE8
 antibodies-online proteins for RNASE8 (11 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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