RNASE8 Gene
protein-coding GIFtS: 40
GCID: GC14P021525
|
|
ribonuclease, RNase A family, 8
| |
Aliases
for RNASE8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribonuclease, RNase A Family, 81 2 | | RNase 83 | | Ribonuclease 82 | | EC 3.1.278 | | RNase 8, Placental2 | | EC 3.1.27.58 | | EC 3.1.27.-3 | | |
Export aliases for RNASE8 gene to outside databasesPrevious GC identifers: GC14P018898 GC14P015313 GC14P019516 GC14P020595 GC14P001647 |
Summaries
for RNASE8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3Function: Has a low ribonuclease activity
|
Genomic Views
for RNASE8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNASE8 gene promoter:
TBP AML1a Brachyury MyoD PPAR-alpha c-Rel FOXJ2 (long isoform) FOXJ2 MRF-2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNASE8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.1RNASE8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P021525: view genomic region
(about GC identifiers)
Start:
|
21,525,981 bp from pter |
End:
|
21,526,614 bp from pter |
Size:
|
634 bases |
Orientation:
|
plus strand |
|
Proteins
for RNASE8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3 (See
protein sequence)Recommended Name: Ribonuclease 8 precursor Size: 154 amino acids; 17041 Da
Subcellular location: Secreted (Probable)
Secondary accessions: B2RPP6 B2RPP7Explore the universe of human proteins at neXtProt for RNASE8: NX_Q8TDE3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TDE3
4/5 DME Specific Peptides for RNASE8 (Q8TDE3) (see all 5)
RNASE8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612204.1
ENSEMBL proteins: ENSP00000311398
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
RNASE8 for ontologies About GeneDecksing
RNASE8 Antibody Products:
Assay Products for RNASE8: |
Protein
Domains /
Families
for RNASE8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNASE8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8TDE3ProtoNet protein and cluster: Q8TDE3 1 Blocks protein family: IPB001427 Pancreatic ribonuclease
UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3Similarity: Belongs to the pancreatic ribonuclease family |
Function
for RNASE8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3Function: Has a low ribonuclease activityEnzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNASE8 (NM_138331) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE8 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
RNASE8 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNASE8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE8
|
Drugs & Compounds
for RNASE8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNASE8
Search CenterWatch for drugs/clinical trials and news about RNASE8 / RNAS8
|
Transcripts
for RNASE8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNASE8 gene: NM_138331.1 Unigene Cluster for RNASE8: Ribonuclease, RNase A family, 8 Hs.553572 Unigene Representative Sequence: JQ3536791 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000308227(uc010tlm.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNASE8 (NM_138331) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE8 |
Additional cDNA sequence: BC137537.1 BC137538.1 JQ353679.1 1 AceView cDNA sequence: NM_138331
GeneLoc Exon Structure
|
Expression
for RNASE8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNASE8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTGAGCTCA
About this image
See RNASE8 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.553572
UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3Tissue specificity: Expressed prominently in the placenta and is not detected in any other tissues examined
SABiosciences Custom PCR Arrays for RNASE8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RNASE8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE8 |
Orthologs
for RNASE8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNASE8 gene from 3/7 species (see all 7) About this table
Species with no ortholog for RNASE8
ENSEMBL Gene Tree for RNASE8 (if available)
TreeFam Gene Tree for RNASE8 (if available) |
Paralogs
for RNASE8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNASE8 gene
- RNASE32 RNASE72 ANG2 RNASE62 RNASE42 RNASE12 RNASE22 ENSG000002588182
6 SIMAP similar genes for RNASE8 using alignment to 7 protein entries: RNAS8_HUMAN (see all proteins):RNASE7 RNASE6 RNASE2 ECRP RNASE3 RNASE1
RNASE8 for paralogs About GeneDecksing
|
Genomic Variants
for RNASE8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNASE8 (21525981 - 21526614 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNASE8: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE8 |
|
Disorders
/ Diseases
for RNASE8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNASE8 for disorders About GeneDecksing
OMIM gene information: 612485
OMIM disorders: --
1  disease for RNASE8: About MalaCardspancreatitis
Export disorders for RNASE8 gene to outside databases
|
Publications
for RNASE8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNASE8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNASE8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. (PubMed id 11861908)1, 2, 3, 9 Zhang J.... Rosenberg H.F. (2002)
- Disulfide-bond reshuffling in the evolution of an ape placental ribonuclease. (PubMed id 17116644)1, 9 Zhang J. (2007)
- Genetic diversity of human RNase 8. (PubMed id 22272736)1 Chan C.C.... Rosenberg H.F. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Identification of RNase 8 as a novel human antimicrobial protein. (PubMed id 16940129)9 Rudolph B....Harder J. (2006)
|
External Searches for RNASE8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNASE8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNASE8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNASE8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNASE8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNASE8 gene:
Search GeneIP for patents involving RNASE8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNASE8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNASE8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE8 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNASE8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNASE8 | | OriGene Custom Protein Services for RNASE8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASE8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE8 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RNASE8 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RNASE8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RNASE8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE8 |
|
|
|
|
