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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE8 Gene

protein-coding   GIFtS: 43
GCID: GC14P021525

Ribonuclease, RNase A Family, 8

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, 81 2     RNase 83
Ribonuclease 82     EC 3.1.278
RNase 8, Placental2     EC 3.1.27.58
EC 3.1.27.-3     

External Ids:    HGNC: 192771   Entrez Gene: 1226652   Ensembl: ENSG000001734317   OMIM: 6124855   UniProtKB: Q8TDE33   

Export aliases for RNASE8 gene to outside databases

Previous GC identifers: GC14P018898 GC14P015313 GC14P019516 GC14P020595 GC14P001647


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNASE8 Gene: 
RNASE8 (ribonuclease, RNase A family, 8) is a protein-coding gene. Diseases associated with RNASE8 include pancreatitis. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3
Function: Has a low ribonuclease activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE8 gene promoter:
         TBP   AML1a   Brachyury   MyoD   PPAR-alpha   c-Rel   FOXJ2 (long isoform)   FOXJ2   MRF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE8 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASE8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RNASE8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021525:  view genomic region     (about GC identifiers)

Start:
21,525,981 bp from pter      End:
21,526,614 bp from pter
Size:
634 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3 (See protein sequence)
Recommended Name: Ribonuclease 8 precursor  
Size: 154 amino acids; 17041 Da
Subcellular location: Secreted (Probable)
Secondary accessions: B2RPP6 B2RPP7

Explore the universe of human proteins at neXtProt for RNASE8: NX_Q8TDE3

Explore proteomics data for RNASE8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TDE3

  • 4/5 DME Specific Peptides for RNASE8 (Q8TDE3) (see all 5)
     TCQTPNI  LVPVHLD  CKDLNTFLH  LLLLLLGLWVA 

    RNASE8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNASE8 Protein Expression
    REFSEQ proteins: NP_612204.1  
    ENSEMBL proteins: 
     ENSP00000311398  

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    Cloud-Clone Corp. Proteins for RNASE8 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    RNASE8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry Q8TDE3

    ProtoNet protein and cluster: Q8TDE3

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3
    Similarity: Belongs to the pancreatic ribonuclease family


    RNASE8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNAS8_HUMAN, Q8TDE3
    Function: Has a low ribonuclease activity

         Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004522pancreatic ribonuclease activity IDA11861908
         
    RNASE8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE8 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for RNASE8:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASE8 (RNAS8)

    Search CenterWatch for drugs/clinical trials and news about RNASE8 / RNAS8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNASE8 gene: 
    NM_138331.1  

    Unigene Cluster for RNASE8:

    Ribonuclease, RNase A family, 8
    Hs.553572
    Unigene Representative Sequence: JQ353679
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000308227(uc010tlm.2)
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE8

    Additional mRNA sequence: 

    BC137537.1 BC137538.1 JQ353679.1 

    1 AceView cDNA sequence:

    NM_138331 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASE8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGAGCTCA
    RNASE8 Expression
    About this image


    See RNASE8 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.553572

    UniProtKB/Swiss-Prot: RNAS8_HUMAN, Q8TDE3
    Tissue specificity: Expressed prominently in the placenta and is not detected in any other tissues examined

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE8 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia RNASE81 ribonuclease, RNase A family, 8 56.41(n)
    46.15(a)
      100688316  XM_003432008.1  XP_003432056.1 
    chicken
    (Gallus gallus)
    Aves CL26
    ANG6
    (see all 3)
    Angiogenin
    (see all 3)
    24(a)
    23(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    4(49041665-49042706)
    6(8796401-8797835)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    24(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343220.1(1279015-1279452)
    GL343220.1(1531632-1532063)


    ENSEMBL Gene Tree for RNASE8 (if available)
    TreeFam Gene Tree for RNASE8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNASE8 gene
    RNASE32  RNASE72  RNASE22  RNASE12  ANG2  RNASE62  RNASE42  
    6 SIMAP similar genes for RNASE8 using alignment to 7 protein entries:     RNAS8_HUMAN (see all proteins):
    RNASE7    RNASE6    RNASE2    ECRP    RNASE3    RNASE1

    RNASE8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/88 SNPs in RNASE8 are shown (see all 88)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1928272311,2
    --21524057(+) TGTTCC/TCTGCT 1 -- us2k10--------
    rs743206891,2
    F--21524063(+) CTGCTG/ACCCAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1508109441,2
    C--21524167(+) GAAAAC/GGTGAG 1 -- us2k10--------
    rs800839231,2
    C,F--21524215(+) TGAGAT/GGACAA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs777092951,2
    C,F--21524218(+) GATGAC/TAAACA 1 -- us2k13Minor allele frequency- T:0.05WA NA EA 358
    rs101339681,2
    C,F,A,H--21524270(+) TCGGCG/AAATTT 1 -- us2k123Minor allele frequency- A:0.19NS EA NA WA CSA 2351
    rs1853086911,2
    --21524304(+) CCCAAA/CGGTGG 1 -- us2k10--------
    rs1145663451,2
    F--21524475(+) TAATAC/TGCTAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs751356761,2
    F--21524476(+) AATACA/GCTAAA 1 -- us2k10--------
    rs1875303591,2
    --21524556(+) TACTAA/GTGTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNASE8 (21525981 - 21526614 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNASE8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832740CNV Gain17160897
    nsv826882CNV Gain20364138
    nsv428293CNV Gain+Loss18775914

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612485    OMIM disorders: --

    2 diseases for RNASE8:    About MalaCards
    pancreatitis    


    RNASE8 for disorders           About GeneDecksing


    Export disorders for RNASE8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASE8 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with RNASE8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. (PubMed id 11861908)1, 2, 3, 9 Zhang J.... Rosenberg H.F. (2002)
    2. Disulfide-bond reshuffling in the evolution of an ape placental ribonuclease. (PubMed id 17116644)1, 9 Zhang J. (2007)
    3. Genetic diversity of human RNase 8. (PubMed id 22272736)1 Chan C.C.... Rosenberg H.F. (2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Identification of RNase 8 as a novel human antimicrobial protein. (PubMed id 16940129)9 Rudolph B....Harder J. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 122665 HGNC: 19277 AceView: RNASE8 Ensembl:ENSG00000173431 euGenes: HUgn122665
    ECgene: RNASE8 H-InvDB: RNASE8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNASE8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNASE8 gene:
    Search GeneIP for patents involving RNASE8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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