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Aliases for RNASE8 Gene

Aliases for RNASE8 Gene

  • Ribonuclease A Family Member 8 2 3
  • Ribonuclease, RNase A Family, 8 2 3 5
  • RNase 8, Placental 3
  • EC 63
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • RNase 8 4
  • RAE2 3

External Ids for RNASE8 Gene

Previous GeneCards Identifiers for RNASE8 Gene

  • GC14P018898
  • GC14P015313
  • GC14P019516
  • GC14P020595
  • GC14P021525
  • GC14P001647

Summaries for RNASE8 Gene

Entrez Gene Summary for RNASE8 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE8 Gene

RNASE8 (Ribonuclease A Family Member 8) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE8 Gene

  • Has a low ribonuclease activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE8 Gene

Genomics for RNASE8 Gene

Regulatory Elements for RNASE8 Gene

Enhancers for RNASE8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNASE8 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE8 Gene

21,057,822 bp from pter
21,058,455 bp from pter
634 bases
Plus strand

Genomic View for RNASE8 Gene

Genes around RNASE8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE8 Gene

Proteins for RNASE8 Gene

  • Protein details for RNASE8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease 8
    Protein Accession:
    Secondary Accessions:
    • B2RPP6
    • B2RPP7

    Protein attributes for RNASE8 Gene

    154 amino acids
    Molecular mass:
    17041 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE8 Gene

Proteomics data for RNASE8 Gene at MOPED

Selected DME Specific Peptides for RNASE8 Gene

Post-translational modifications for RNASE8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNASE8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE8 Gene

Gene Families for RNASE8 Gene

Protein Domains for RNASE8 Gene

Suggested Antigen Peptide Sequences for RNASE8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE8: view

Function for RNASE8 Gene

Molecular function for RNASE8 Gene

UniProtKB/Swiss-Prot Function:
Has a low ribonuclease activity.

Enzyme Numbers (IUBMB) for RNASE8 Gene

genes like me logo Genes that share phenotypes with RNASE8: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE8 Gene

Localization for RNASE8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE8 Gene


Subcellular locations from

Jensen Localization Image for RNASE8 Gene COMPARTMENTS Subcellular localization image for RNASE8 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for RNASE8 Gene

Pathways & Interactions for RNASE8 Gene

SuperPathways for RNASE8 Gene

No Data Available

Interacting Proteins for RNASE8 Gene

Gene Ontology (GO) - Biological Process for RNASE8 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNASE8 Gene

Drugs & Compounds for RNASE8 Gene

No Compound Related Data Available

Transcripts for RNASE8 Gene

mRNA/cDNA for RNASE8 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE8 Gene

No ASD Table

Relevant External Links for RNASE8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE8 Gene

mRNA expression in normal human tissues for RNASE8 Gene

SOURCE GeneReport for Unigene cluster for RNASE8 Gene Hs.553572

mRNA Expression by UniProt/SwissProt for RNASE8 Gene

Tissue specificity: Expressed prominently in the placenta and is not detected in any other tissues examined.
genes like me logo Genes that share expression patterns with RNASE8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RNASE8 Gene

Orthologs for RNASE8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE8 35
  • 97.84 (n)
  • 96.1 (a)
  • 94 (a)
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
(Gallus gallus)
Aves ANG 36
  • 27 (a)
CL2 36
  • 26 (a)
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
-- 36
  • 24 (a)
Species with no ortholog for RNASE8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE8 Gene

Gene Tree for RNASE8 (if available)
Gene Tree for RNASE8 (if available)

Paralogs for RNASE8 Gene

Paralogs for RNASE8 Gene

(6) SIMAP similar genes for RNASE8 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RNASE8: view

Variants for RNASE8 Gene

Sequence variations from dbSNP and Humsavar for RNASE8 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_052194 -

Structural Variations from Database of Genomic Variants (DGV) for RNASE8 Gene

Variant ID Type Subtype PubMed ID
nsv428293 CNV Gain+Loss 18775914
nsv832740 CNV Gain 17160897
nsv826882 CNV Gain 20364138

Variation tolerance for RNASE8 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNASE8 Gene

Disorders for RNASE8 Gene

Relevant External Links for RNASE8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNASE8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE8 Gene

Publications for RNASE8 Gene

  1. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. (PMID: 11861908) Zhang J. … Rosenberg H.F. (Nucleic Acids Res. 2002) 2 3 4 23 67
  2. Disulfide-bond reshuffling in the evolution of an ape placental ribonuclease. (PMID: 17116644) Zhang J. (Mol. Biol. Evol. 2007) 3 23
  3. Identification of RNase 8 as a novel human antimicrobial protein. (PMID: 16940129) Rudolph B. … Harder J. (Antimicrob. Agents Chemother. 2006) 3 23
  4. Genetic diversity of human RNase 8. (PMID: 22272736) Chan C.C. … Rosenberg H.F. (BMC Genomics 2012) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RNASE8 Gene

Sources for RNASE8 Gene