RNASE7 Gene
protein-coding GIFtS: 45
GCID: GC14P021510
|
|
ribonuclease, RNase A family, 7
| |
Aliases
for RNASE7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribonuclease, RNase A Family, 71 2 | | Ribonuclease 72 | | Skin-Derived Antimicrobial Protein 22 3 | | EC 3.1.27.-3 | | SAP-22 3 | | EC 3.1.278 | | RNase 72 3 | | EC 3.1.27.58 |
Export aliases for RNASE7 gene to outside databasesPrevious GC identifers: GC14P018883 GC14P015298 GC14P019500 GC14P020580 GC14P001631 |
Summaries
for RNASE7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RNASE7:
RNASE7 is a member of the RNase A superfamily that has broad-spectrum antimicrobial activity and ribonuclease activity(Harder and Schroder, 2002 (PubMed 12244054); Zhang et al., 2003 (PubMed 12527768)).(supplied by OMIM, Dec 2008)
UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1Function: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenicmicroorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcusfaecium
|
Genomic Views
for RNASE7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNASE7 gene promoter:
TBP Spz1 RP58 Nkx2-5 PPAR-alpha CREB PPAR-gamma1 c-Rel deltaCREB PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNASE7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.1RNASE7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P021510: view genomic region
(about GC identifiers)
Start:
|
21,510,385 bp from pter |
End:
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21,512,393 bp from pter |
Size:
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2,009 bases |
Orientation:
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plus strand |
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Proteins
for RNASE7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1 (See
protein sequence)Recommended Name: Ribonuclease 7 precursor Size: 156 amino acids; 17419 Da
Subcellular location: Secreted
1 PDB 3D structure from  and Proteopedia  for RNASE7:2HKY (3D)
Secondary accessions: P80927 P83685 Q546N3Explore the universe of human proteins at neXtProt for RNASE7: NX_Q9H1E1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H1E1
4 DME Specific Peptides for RNASE7 (Q9H1E1)
RNASE7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115961.2
ENSEMBL proteins: ENSP00000298690 ENSP00000431382
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
RNASE7 for ontologies About GeneDecksing
RNASE7 Antibody Products:
Assay Products for RNASE7: |
Protein
Domains /
Families
for RNASE7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNASE7 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H1E1ProtoNet protein and cluster: Q9H1E1 1 Blocks protein family: IPB001427 Pancreatic ribonuclease
UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1Similarity: Belongs to the pancreatic ribonuclease family |
Function
for RNASE7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1Function: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenicmicroorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant EnterococcusfaeciumEnzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE7
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNASE7 (NM_032572) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE7 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RNASE7 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNASE7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE7
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
RNASE7 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNASE7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RNASE7 for compounds About GeneDecksing
 Browse Tocris compounds for RNASE7
1 Novoseek chemical compound relationship for RNASE7 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lysine |
39.7 |
2 |
12527768 (1), 17150966 (1) |
Search CenterWatch for drugs/clinical trials and news about RNASE7 / RNAS7
|
Transcripts
for RNASE7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNASE7 gene: NM_032572.3 Unigene Cluster for RNASE7: Ribonuclease, RNase A family, 7 Hs.525206 [show with all ESTs]Unigene Representative Sequence: AK0233432 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298690(uc001vzk.4 uc001vzl.2) ENST00000481538
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE7
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNASE7 (NM_032572) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE7 |
Additional cDNA sequence: AJ306609.1 AJ306610.1 AK023343.1 AK292697.1 AY170392.1 AY359097.1 BC074960.2 BC112334.1 3 DOTS entries: DT.102821283 DT.100744155 DT.97783611 14 AceView cDNA sequences: BG697903 AI150610 BX100315 AJ306608 BU680048 AY359097 BC074960 NM_032572 AJ306609 AJ306610 AY170392 AJ131212 CD634121 CD634123
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for RNASE7 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for RNASE7
|
Expression
for RNASE7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNASE7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RNASE7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASE7
SOURCE GeneReport for Unigene cluster: Hs.525206
UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1Tissue specificity: Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tractand, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart
SABiosciences Custom PCR Arrays for RNASE7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RNASE7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE7 |
Orthologs
for RNASE7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNASE7 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for RNASE7 (if available)
TreeFam Gene Tree for RNASE7 (if available) |
Paralogs
for RNASE7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNASE7 gene
- RNASE32 RNASE82 ANG2 RNASE62 RNASE42 RNASE12 RNASE22 ENSG000002588182
7 SIMAP similar genes for RNASE7 using alignment to 2 protein entries: RNAS7_HUMAN (see all proteins):RNASE8 RNASE6 RNASE2 RNASE3 ECRP RNASE1
RNASE4
RNASE7 for paralogs About GeneDecksing
|
Genomic Variants
for RNASE7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNASE7 (21510385 - 21512393 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNASE7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE7 |
|
Disorders
/ Diseases
for RNASE7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNASE7 for disorders About GeneDecksing
OMIM gene information: 612484
OMIM disorders: --
8  diseases for RNASE7: About MalaCardshidradenitis suppurativa lichen sclerosus hidradenitis atopic dermatitis
dermatitis psoriasis gastritis pancreatitis
1 Novoseek disease relationship for RNASE7 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| psoriasis |
50 |
1 |
20107483 (1) |
Export disorders for RNASE7 gene to outside databases
|
Publications
for RNASE7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNASE7 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with RNASE7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. (PubMed id 12527768)1, 2, 3, 9 Zhang J.... Rosenberg H.F. (2003)
- RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. (PubMed id 12244054)1, 2, 3, 9 Harder J. and Schroeder J.M. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- RNase 7 contributes to the cutaneous defense against Enterococcus faecium. (PubMed id 19641608)1, 9 KAPten B....Harder J. (2009)
- Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7. (PubMed id 19366593)1, 9 Torrent M....Boix E. (2009)
- Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin. (PubMed id 19919305)1, 9 Zanger P....Gabrysch S. (2009)
- The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity. (PubMed id 17150966)2, 9 Huang Y.-C.... Liao Y.-D. (2007)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- RNase 7 protects healthy skin from Staphylococcus aur eus colonization. (PubMed id 20668470)1 Simanski M....Harder J. (2010)
|
External Searches for RNASE7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNASE7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNASE7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNASE7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNASE7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNASE7 gene:
Search GeneIP for patents involving RNASE7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNASE7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASE7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE7 |
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| |  |  |  |  | | | | |
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 | | | RNASE7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE7 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE7 |
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