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Aliases for RNASE7 Gene

Aliases for RNASE7 Gene

  • Ribonuclease, RNase A Family, 7 2 3
  • Skin-Derived Antimicrobial Protein 2 3 4
  • RNase 7 3 4
  • SAP-2 3 4
  • Ribonuclease 7 3
  • EC 3.1.27.5 63
  • EC 3.1.27.- 4
  • EC 3.1.27 63

External Ids for RNASE7 Gene

Summaries for RNASE7 Gene

Entrez Gene Summary for RNASE7 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE7 Gene

RNASE7 (Ribonuclease, RNase A Family, 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE7 Gene

  • Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE7 Gene

Genomics for RNASE7 Gene

Genomic Location for RNASE7 Gene

Start:
21,042,226 bp from pter
End:
21,044,234 bp from pter
Size:
2,009 bases
Orientation:
Plus strand

Genomic View for RNASE7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE7 Gene

Regulatory Elements for RNASE7 Gene

Proteins for RNASE7 Gene

  • Protein details for RNASE7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1E1-RNAS7_HUMAN
    Recommended name:
    Ribonuclease 7
    Protein Accession:
    Q9H1E1
    Secondary Accessions:
    • P80927
    • P83685
    • Q546N3

    Protein attributes for RNASE7 Gene

    Size:
    156 amino acids
    Molecular mass:
    17419 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE7 Gene

neXtProt entry for RNASE7 Gene

Proteomics data for RNASE7 Gene at MOPED

Selected DME Specific Peptides for RNASE7 Gene

Post-translational modifications for RNASE7 Gene

Other Protein References for RNASE7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for RNASE7 Gene

Gene Families for RNASE7 Gene

HGNC:
  • RNASE :Ribonucleases, RNase A

Protein Domains for RNASE7 Gene

Suggested Antigen Peptide Sequences for RNASE7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1E1

UniProtKB/Swiss-Prot:

RNAS7_HUMAN
Family:
  • Belongs to the pancreatic ribonuclease family.:
    • Q9H1E1
genes like me logo Genes that share domains with RNASE7: view

Function for RNASE7 Gene

Molecular function for RNASE7 Gene

UniProtKB/Swiss-Prot Function: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium.

Enzyme Numbers (IUBMB) for RNASE7 Gene

Gene Ontology (GO) - Molecular Function for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 20180804
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity IDA 12244054
GO:0042834 peptidoglycan binding IDA 20180804
genes like me logo Genes that share ontologies with RNASE7: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNASE7 Gene

Localization for RNASE7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE7 Gene COMPARTMENTS Subcellular localization image for RNASE7 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 12244054
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE7: view

Pathways for RNASE7 Gene

SuperPathways for RNASE7 Gene

No Data Available

Interacting Proteins for RNASE7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000298690%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000298690 for RNASE7 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009617 response to bacterium NAS 12244054
GO:0019731 antibacterial humoral response IDA 23302724
GO:0045087 innate immune response NAS 12244054
GO:0050829 defense response to Gram-negative bacterium IDA 20180804
GO:0050830 defense response to Gram-positive bacterium IDA 19641608
genes like me logo Genes that share ontologies with RNASE7: view

No data available for Pathways by source for RNASE7 Gene

Compounds for RNASE7 Gene

(1) Novoseek inferred chemical compound relationships for RNASE7 Gene

Compound -log(P) Hits PubMed IDs
lysine 39.7 2
genes like me logo Genes that share compounds with RNASE7: view

Transcripts for RNASE7 Gene

mRNA/cDNA for RNASE7 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE7 Gene

Ribonuclease, RNase A family, 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for RNASE7 Gene

GeneLoc Exon Structure for
RNASE7
ECgene alternative splicing isoforms for
RNASE7

Expression for RNASE7 Gene

mRNA expression in normal human tissues for RNASE7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE7 Gene

This gene is overexpressed in Esophagus - Mucosa (22.0), Skin - Sun Exposed (Lower leg) (10.7), Vagina (6.4), and Skin - Not Sun Exposed (Suprapubic) (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNASE7 Gene

SOURCE GeneReport for Unigene cluster for RNASE7 Gene Hs.525206

mRNA Expression by UniProt/SwissProt for RNASE7 Gene

Q9H1E1-RNAS7_HUMAN
Tissue specificity: Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart.
genes like me logo Genes that share expressions with RNASE7: view

Orthologs for RNASE7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE7 35
  • 98.72 (n)
  • 98.72 (a)
RNASE7 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 72 (a)
OneToMany
RNASE7 35
  • 79.27 (n)
  • 69.23 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANG 36
  • 28 (a)
ManyToMany
CL2 36
  • 26 (a)
ManyToMany
RSFR 36
  • 29 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
Species with no ortholog for RNASE7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE7 Gene

ENSEMBL:
Gene Tree for RNASE7 (if available)
TreeFam:
Gene Tree for RNASE7 (if available)

Paralogs for RNASE7 Gene

Paralogs for RNASE7 Gene

Selected SIMAP similar genes for RNASE7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE7: view

Variants for RNASE7 Gene

Sequence variations from dbSNP and Humsavar for RNASE7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
VAR_024619 -
VAR_024620 -

Structural Variations from Database of Genomic Variants (DGV) for RNASE7 Gene

Variant ID Type Subtype PubMed ID
nsv428293 CNV Gain+Loss 18775914
nsv832740 CNV Gain 17160897
nsv826882 CNV Gain 20364138

Relevant External Links for RNASE7 Gene

HapMap Linkage Disequilibrium report
RNASE7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE7 Gene

Disorders for RNASE7 Gene

(1) Novoseek inferred disease relationships for RNASE7 Gene

Disease -log(P) Hits PubMed IDs
psoriasis 50 1
genes like me logo Genes that share disorders with RNASE7: view

No data available for UniProtKB/Swiss-Prot for RNASE7 Gene

Publications for RNASE7 Gene

  1. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. (PMID: 12244054) Harder J. … Schroeder J.M. (J. Biol. Chem. 2002) 2 3 4 23
  2. Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. (PMID: 12527768) Zhang J. … Rosenberg H.F. (Nucleic Acids Res. 2003) 2 3 4 23
  3. Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7. (PMID: 19366593) Torrent M. … Boix E. (Biochim. Biophys. Acta 2009) 3 23
  4. The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity. (PMID: 17150966) Huang Y.-C. … Liao Y.-D. (J. Biol. Chem. 2007) 4 23
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for RNASE7 Gene

Sources for RNASE7 Gene

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