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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE7 Gene

protein-coding   GIFtS: 47
GCID: GC14P021510

Ribonuclease, RNase A Family, 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, 71 2     Ribonuclease 72
Skin-Derived Antimicrobial Protein 22 3     EC 3.1.27.-3
SAP-22 3     EC 3.1.278
RNase 72 3     EC 3.1.27.58

External Ids:    HGNC: 192781   Entrez Gene: 846592   Ensembl: ENSG000001657997   OMIM: 6124845   UniProtKB: Q9H1E13   

Export aliases for RNASE7 gene to outside databases

Previous GC identifers: GC14P018883 GC14P015298 GC14P019500 GC14P020580 GC14P001631


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNASE7 Gene:
RNASE7 is a member of the RNase A superfamily that has broad-spectrum antimicrobial activity and ribonuclease
activity (Harder and Schroder, 2002 (PubMed 12244054); Zhang et al., 2003 (PubMed 12527768)).(supplied by OMIM,
Dec 2008)

GeneCards Summary for RNASE7 Gene: 
RNASE7 (ribonuclease, RNase A family, 7) is a protein-coding gene. Diseases associated with RNASE7 include lichen sclerosus, and hidradenitis suppurativa. GO annotations related to this gene include ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1
Function: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic
microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant
Enterococcus faecium




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE7 gene promoter:
         TBP   Spz1   RP58   Nkx2-5   PPAR-alpha   CREB   PPAR-gamma1   c-Rel   deltaCREB   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE7 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASE7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RNASE7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE7 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021510:  view genomic region     (about GC identifiers)

Start:
21,510,385 bp from pter      End:
21,512,393 bp from pter
Size:
2,009 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1 (See protein sequence)
Recommended Name: Ribonuclease 7 precursor  
Size: 156 amino acids; 17419 Da
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for RNASE7:
2HKY (3D)    
Secondary accessions: P80927 P83685 Q546N3

Explore the universe of human proteins at neXtProt for RNASE7: NX_Q9H1E1

Explore proteomics data for RNASE7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H1E1

  • 4 DME Specific Peptides for RNASE7 (Q9H1E1)
     LVPVHLD  CKDLNTFLH  LLLLLLGLWVA  LTSGKYPNCRYKE 

    RNASE7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNASE7 Protein Expression
    REFSEQ proteins: NP_115961.2  
    ENSEMBL proteins: 
     ENSP00000298690   ENSP00000431382  

    Human Recombinant Protein Products for RNASE7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for RNASE7
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RNASE7
    GenScript Custom Purified and Recombinant Proteins Services for RNASE7
    Novus Biologicals RNASE7 Proteins
    Novus Biologicals RNASE7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNASE7 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS12244054

    RNASE7 for ontologies           About GeneDecksing



    RNASE7 Antibody Products: 
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    Assay Products for RNASE7: 
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    Cloud-Clone Corp. ELISAs for RNASE7 
    Cloud-Clone Corp. CLIAs for RNASE7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry Q9H1E1

    ProtoNet protein and cluster: Q9H1E1

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1
    Similarity: Belongs to the pancreatic ribonuclease family


    RNASE7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNAS7_HUMAN, Q9H1E1
    Function: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic
    microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant
    Enterococcus faecium

         Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0004540ribonuclease activity IDA12244054
         
    RNASE7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASE7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE7
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASE7:
    hsa-miR-875-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNASE7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNASE7
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for RNASE7 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE7 (NM_032572)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE7
    Sirion Biotech Customized lentivirus for stable overexpression of RNASE7 
                         Customized lentivirus expression plasmids for stable overexpression of RNASE7 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE7

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009617response to bacterium NAS12244054
    GO:0042742defense response to bacterium IEA--
    GO:0045087innate immune response NAS12244054

    RNASE7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNASE7 for compounds           About GeneDecksing

    EMD Millipore small molecules for RNASE7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASE7 (RNAS7)

    1 Novoseek inferred chemical compound relationship for RNASE7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 39.7 2 12527768 (1), 17150966 (1)

    Search CenterWatch for drugs/clinical trials and news about RNASE7 / RNAS7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNASE7 gene: 
    NM_032572.3  

    Unigene Cluster for RNASE7:

    Ribonuclease, RNase A family, 7
    Hs.525206  [show with all ESTs]
    Unigene Representative Sequence: AK023343
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298690(uc001vzk.4 uc001vzl.2) ENST00000481538
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE7
    1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASE7:
    hsa-miR-875-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNASE7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNASE7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE7
    Clone
    Products:
         
    OriGene clones in human, mouse for RNASE7 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE7 (NM_032572)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE7
    Sirion Biotech Customized lentivirus for stable overexpression of RNASE7 
                         Customized lentivirus expression plasmids for stable overexpression of RNASE7 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASE7
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RNASE7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE7

    Additional mRNA sequence: 

    AJ306609.1 AJ306610.1 AK023343.1 AK292697.1 AY170392.1 AY359097.1 BC074960.2 BC112334.1 

    3 DOTS entries:

    DT.102821283  DT.100744155  DT.97783611 

    14 AceView cDNA sequences:

    AI150610 BG697903 NM_032572 BC074960 BX100315 AY359097 AJ306608 AY170392 
    AJ306609 BU680048 AJ306610 AJ131212 CD634123 CD634121 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RNASE7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for RNASE7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASE7 expression in normal human tissues (normalized intensities)      RNASE7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNASE7 Expression
    About this image


    RNASE7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
             Human Small Airway Epithelial Cells (HSAEpiC)   
     
     Epithelium
             Human Small Airway Epithelial Cells (HSAEpiC)   
     
     Epidermis (Integumentary System)
             Human EpiDermal Keratinocytes-adult (HEK-a)   
     
     Breast (Uncategorized)
             Human Mammary Epithelial Cells (HMEpiC)   
     
     Fibroblast
             Human Dermal Fibroblasts-fetal (HDF-f)   

    See RNASE7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNASE7

    SOURCE GeneReport for Unigene cluster: Hs.525206

    UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1
    Tissue specificity: Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary
    tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart

        SABiosciences Custom PCR Arrays for RNASE7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE7 gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    54(a)
    36(a)
    (see all 4)
    1 ↔ many
    possible ortholog
    (see all 4)
    1(169623910-169624371)
    1(168865082-168865552)
    chicken
    (Gallus gallus)
    Aves RSFR6
    ANG6
    (see all 3)
    Angiogenin
    (see all 3)
    27(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(8804970-8806179)
    6(8796401-8797835)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    27(a)
    26(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343220.1(1279015-1279452)
    GL343220.1(1531632-1532063)


    ENSEMBL Gene Tree for RNASE7 (if available)
    TreeFam Gene Tree for RNASE7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNASE7 gene
    RNASE32  RNASE82  RNASE22  RNASE12  ANG2  RNASE62  RNASE42  
    6 SIMAP similar genes for RNASE7 using alignment to 2 protein entries:     RNAS7_HUMAN (see all proteins):
    RNASE8    RNASE6    RNASE2    RNASE3    ECRP    RNASE1

    RNASE7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/124 SNPs in RNASE7 are shown (see all 124)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0246204
    ----see VAR_0246202 H Y mis40--------
    rs1925616761,2
    --21508454(+) CATCTC/TCAGCA 1 -- us2k10--------
    rs1843638991,2
    --21508521(+) CAGCTA/GCTAAA 1 -- us2k10--------
    rs1896504871,2
    --21508531(+) AATAAC/TGTCCT 1 -- us2k10--------
    rs1930853361,2
    --21508661(+) AGCCAA/GGTAAT 1 -- us2k10--------
    rs775972891,2
    F--21508676(+) TAAGCT/AGACAC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1479151581,2
    C--21508741(+) AAAAGC/TCACAG 1 -- us2k10--------
    rs1154536731,2
    C,F--21508800(+) TCTCTG/AAACTC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs9431521,2
    C,F,A,H--21508835(+) ggacaC/Aactgc 1 -- us2k18Minor allele frequency- A:0.28NA WA CSA EA 367
    rs1413215541,2
    C--21508851(+) CTCCAA/GCACCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNASE7 (21510385 - 21512393 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNASE7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832740CNV Gain17160897
    nsv826882CNV Gain20364138
    nsv428293CNV Gain+Loss18775914

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASE7
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612484    OMIM disorders: --

    8 diseases for RNASE7:    About MalaCards
    lichen sclerosus    hidradenitis suppurativa    hidradenitis    atopic dermatitis
    psoriasis    gastritis    dermatitis    pancreatitis


    RNASE7 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RNASE7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 50 1 20107483 (1)


    Export disorders for RNASE7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASE7 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with RNASE7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. (PubMed id 12527768)1, 2, 3, 9 Zhang J.... Rosenberg H.F. (2003)
    2. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. (PubMed id 12244054)1, 2, 3, 9 Harder J. and Schroeder J.M. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. RNase 7 contributes to the cutaneous defense against Enterococcus faecium. (PubMed id 19641608)1, 9 KAPten B....Harder J. (2009)
    6. Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7. (PubMed id 19366593)1, 9 Torrent M....Boix E. (2009)
    7. Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin. (PubMed id 19919305)1, 9 Zanger P....Gabrysch S. (2009)
    8. The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity. (PubMed id 17150966)2, 9 Huang Y.-C.... Liao Y.-D. (2007)
    9. MicroRNA-762 is upregulated in human corneal epithelia l cells in response to tear fluid and Pseudomonas aeruginosa antigens and negati vely regulates the expression of host defense genes encoding RNase7 and ST2. (PubMed id 23469087)1 Mun J....Fleiszig S. (2013)
    10. Ribonuclease 7, an antimicrobial peptide upregulated d uring infection, contributes to microbial defense of the human urinary tract. (PubMed id 23302724)1 Spencer J.D....Hains D.S. (2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84659 HGNC: 19278 AceView: RNASE7 Ensembl:ENSG00000165799 euGenes: HUgn84659
    ECgene: RNASE7 H-InvDB: RNASE7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for RNASE7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNASE7 gene:
    Search GeneIP for patents involving RNASE7

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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