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RNASE7 Gene

protein-coding   GIFtS: 48
GCID: GC14P021510

Ribonuclease, RNase A Family, 7

Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease, RNase A Family, 71 2     Ribonuclease 72
Skin-Derived Antimicrobial Protein 22 3     EC 3.1.27.-3
SAP-22 3     EC 3.1.278
RNase 72 3     EC 3.1.27.58

External Ids:    HGNC: 192781   Entrez Gene: 846592   Ensembl: ENSG000001657997   OMIM: 6124845   UniProtKB: Q9H1E13   

Export aliases for RNASE7 gene to outside databases

Previous GC identifers: GC14P018883 GC14P015298 GC14P019500 GC14P020580 GC14P001631


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNASE7 Gene:
RNASE7 is a member of the RNase A superfamily that has broad-spectrum antimicrobial activity and ribonuclease
activity (Harder and Schroder, 2002 (PubMed 12244054); Zhang et al., 2003 (PubMed 12527768)).(supplied by OMIM,
Dec 2008)

GeneCards Summary for RNASE7 Gene:
RNASE7 (ribonuclease, RNase A family, 7) is a protein-coding gene. Diseases associated with RNASE7 include lichen sclerosus, and hidradenitis. GO annotations related to this gene include ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1
Function: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic
microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant
Enterococcus faecium




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE7 gene promoter:
         TBP   Spz1   RP58   Nkx2-5   PPAR-alpha   CREB   PPAR-gamma1   c-Rel   deltaCREB   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE7 promoter sequence
   Search Chromatin IP Primers for RNASE7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RNASE7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE7 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021510:  view genomic region     (about GC identifiers)

Start:
21,510,385 bp from pter      End:
21,512,393 bp from pter
Size:
2,009 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1 (See protein sequence)
Recommended Name: Ribonuclease 7 precursor  
Size: 156 amino acids; 17419 Da
1 PDB 3D structure from and Proteopedia for RNASE7:
2HKY (3D)    
Secondary accessions: P80927 P83685 Q546N3

Explore the universe of human proteins at neXtProt for RNASE7: NX_Q9H1E1

Explore proteomics data for RNASE7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn127
  • 4 DME Specific Peptides for RNASE7 (Q9H1E1)
     LVPVHLD  CKDLNTFLH  LLLLLLGLWVA  LTSGKYPNCRYKE 


    See RNASE7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115961.2  
    ENSEMBL proteins: 
     ENSP00000298690   ENSP00000431382  

    RNASE7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RNASE7
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    Novus Biologicals RNASE7 Proteins
    Novus Biologicals RNASE7 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RNASE7

    RNASE7 Antibody Products:

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    Abcam antibodies for RNASE7
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    LSBio Antibodies in human, mouse, rat for RNASE7

    RNASE7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RNASE7
    Cloud-Clone Corp. CLIAs for RNASE7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry Q9H1E1

    ProtoNet protein and cluster: Q9H1E1

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1
    Similarity: Belongs to the pancreatic ribonuclease family


    RNASE7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNAS7_HUMAN, Q9H1E1
    Function: Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic
    microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant
    Enterococcus faecium

         Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004540ribonuclease activity IDA12244054
    GO:0016892endoribonuclease activity, producing 3'-phosphomonoesters IEA--
         
    RNASE7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNASE7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNASE7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASE7

    miRNA
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    Block miRNA regulation of human, mouse, rat RNASE7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RNASE7:
    hsa-miR-875-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNASE7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RNASE7
    Predesigned siRNA for gene silencing in human, mouse, rat RNASE7

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RNASE7

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE7 (NM_032572)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE7

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RNASE7
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNASE7 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNAS7_HUMAN, Q9H1E1: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS12244054

    RNASE7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASE7
    Interactions:

        Search GeneGlobe Interaction Network for RNASE7

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009617response to bacterium NAS12244054
    GO:0042742defense response to bacterium IEA--
    GO:0045087innate immune response NAS12244054
    GO:0090501RNA phosphodiester bond hydrolysis IDA12244054

    RNASE7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASE7 (RNAS7)

    1 Novoseek inferred chemical compound relationship for RNASE7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 39.7 2 12527768 (1), 17150966 (1)



    RNASE7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNASE7 gene: 
    NM_032572.3  

    Unigene Cluster for RNASE7:

    Ribonuclease, RNase A family, 7
    Hs.525206  [show with all ESTs]
    Unigene Representative Sequence: AK023343
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298690(uc001vzk.4 uc001vzl.2) ENST00000481538

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RNASE7 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RNASE7:
    hsa-miR-875-3p
    SwitchGear 3'UTR luciferase reporter plasmidRNASE7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RNASE7
    Predesigned siRNA for gene silencing in human, mouse, rat RNASE7
    Clone
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    OriGene clones in human, mouse for RNASE7 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE7 (NM_032572)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASE7
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat RNASE7
      QuantiTect SYBR Green Assays in human, mouse, rat RNASE7
      QuantiFast Probe-based Assays in human, mouse, rat RNASE7

    Additional mRNA sequence: 

    AJ306609.1 AJ306610.1 AK023343.1 AK292697.1 AY170392.1 AY359097.1 BC074960.2 BC112334.1 

    3 DOTS entries:

    DT.102821283  DT.100744155  DT.97783611 

    14 AceView cDNA sequences:

    AI150610 BG697903 BX100315 BU680048 AJ306608 AY359097 BC074960 AJ306610 
    NM_032572 AJ306609 AY170392 AJ131212 CD634121 CD634123 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for RNASE7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for RNASE7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASE7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNASE7 Expression
    About this image


    RNASE7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Esophagus (Gastrointestinal Tract)
    RNASE7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASE7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525206

    UniProtKB/Swiss-Prot: RNAS7_HUMAN, Q9H1E1
    Tissue specificity: Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary
    tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart

        Custom PCR Arrays for RNASE7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE7 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia --
    Uncharacterized protein
    54(a)
    1 → many
    1(169623910-169624371)
    chicken
    (Gallus gallus)
    Aves RSFR6
    ANG6
    (see all 3)
    Gallus gallus leukocyte ribonuclease A-2 (RSFR), m...
    Gallus gallus angiogenin, ribonuclease, RNase A fa...
    (see all 3)
    29(a)
    28(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(8804970-8806179)
    6(8796401-8797835)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    26(a)
    25(a)
    many ↔ many
    many ↔ many
    GL343220.1(1531632-1532063)
    GL343220.1(1279015-1279452)


    ENSEMBL Gene Tree for RNASE7 (if available)
    TreeFam Gene Tree for RNASE7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNASE7 gene
    RNASE32  RNASE82  RNASE22  RNASE12  ANG2  RNASE62  RNASE42  
    6 SIMAP similar genes for RNASE7 using alignment to 2 protein entries:     RNAS7_HUMAN (see all proteins):
    RNASE8    RNASE6    RNASE2    RNASE3    ECRP    RNASE1

    RNASE7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNASE7 (see all 124)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925616761,2
    --21508454(+) CATCTC/TCAGCA 1 -- us2k10--------
    rs1843638991,2
    --21508521(+) CAGCTA/GCTAAA 1 -- us2k10--------
    rs1896504871,2
    --21508531(+) AATAAC/TGTCCT 1 -- us2k10--------
    rs1930853361,2
    --21508661(+) AGCCAA/GGTAAT 1 -- us2k10--------
    rs775972891,2
    F--21508676(+) TAAGCT/AGACAC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1479151581,2
    C--21508741(+) AAAAGC/TCACAG 1 -- us2k10--------
    rs1154536731,2
    C,F--21508800(+) TCTCTG/AAACTC 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs9431521,2
    C,F,A,H--21508835(+) ggacaC/Aactgc 1 -- us2k18Minor allele frequency- A:0.28NA WA CSA EA 367
    rs1413215541,2
    C--21508851(+) CTCCAA/GCACCT 1 -- us2k10--------
    rs1143787771,2
    F--21508895(+) CTAGTC/GTCTTC 1 -- us2k11Minor allele frequency- G:0.01WA 118

    HapMap Linkage Disequilibrium report for RNASE7 (21510385 - 21512393 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNASE7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832740CNV Gain17160897
    nsv826882CNV Gain20364138
    nsv428293CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASE7
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612484    OMIM disorders: --

    9 diseases for RNASE7:    
    About MalaCards
    lichen sclerosus    hidradenitis    hidradenitis suppurativa    atopic dermatitis
    psoriasis    gastritis    dermatitis    bronchiolitis
    pancreatitis


    RNASE7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for RNASE7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psoriasis 50 1 20107483 (1)


    Export disorders for RNASE7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNASE7 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with RNASE7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. (PubMed id 12527768)1, 2, 3, 9 Zhang J.... Rosenberg H.F. (Nucleic Acids Res. 2003)
    2. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. (PubMed id 12244054)1, 2, 3, 9 Harder J. and Schroeder J.M. (J. Biol. Chem. 2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. RNase 7 contributes to the cutaneous defense against Enterococcus faecium. (PubMed id 19641608)1, 9 KAPten B....Harder J. (PLoS ONE 2009)
    6. Comparison of the membrane interaction mechanism of two antimicrobial RNases: RNase 3/ECP and RNase 7. (PubMed id 19366593)1, 9 Torrent M....Boix E. (Biochim. Biophys. Acta 2009)
    7. Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin. (PubMed id 19919305)1, 9 Zanger P....Gabrysch S. (J. Infect. Dis. 2009)
    8. The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity. (PubMed id 17150966)2, 9 Huang Y.-C.... Liao Y.-D. (J. Biol. Chem. 2007)
    9. IL-17A and IFN-I^ synergistically induce RNase 7 expression via STAT3 in primary keratinocytes. (PubMed id 23555696)1 Simanski M....Harder J. (PLoS ONE 2013)
    10. MicroRNA-762 is upregulated in human corneal epithelial cells in response to tear fluid and Pseudomonas aeruginosa antigens and negatively regulates the expression of host defense genes encoding RNase7 and ST2. (PubMed id 23469087)1 Mun J....Fleiszig S. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84659 HGNC: 19278 AceView: RNASE7 Ensembl:ENSG00000165799 euGenes: HUgn84659
    ECgene: RNASE7 H-InvDB: RNASE7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNASE7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNASE7 gene:
    Search GeneIP for patents involving RNASE7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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