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Aliases for RNASE7 Gene

Aliases for RNASE7 Gene

  • Ribonuclease A Family Member 7 2 3 5
  • Skin-Derived Antimicrobial Protein 2 3 4
  • Ribonuclease, RNase A Family, 7 2 3
  • RNase 7 3 4
  • SAP-2 3 4
  • Ribonuclease 7 3
  • EC 3.1.27.5 58
  • EC 3.1.27.- 4
  • EC 3.1.27 58
  • RAE1 3

External Ids for RNASE7 Gene

Previous GeneCards Identifiers for RNASE7 Gene

  • GC14P018883
  • GC14P015298
  • GC14P019500
  • GC14P020580
  • GC14P021510
  • GC14P001631

Summaries for RNASE7 Gene

Entrez Gene Summary for RNASE7 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE7 Gene

RNASE7 (Ribonuclease A Family Member 7) is a Protein Coding gene. Among its related pathways are Innate Immune System and Defensins. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE8.

UniProtKB/Swiss-Prot for RNASE7 Gene

  • Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium.

Additional gene information for RNASE7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE7 Gene

Genomics for RNASE7 Gene

Regulatory Elements for RNASE7 Gene

Enhancers for RNASE7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H021068 1.6 FANTOM5 ENCODE dbSUPER 10.9 +28.8 28819 5 HDGF ARID4B DMAP1 ZBTB7B ZNF143 FOS PAF1 SP3 SP5 ZHX2 ARHGEF40 SUPT16H METTL3 TMEM253 ZNF219 RNASE7 TPPP2 RNASE13 ENSG00000255472 CHD8
GH14H021014 1.2 Ensembl ENCODE 11.3 -26.9 -26919 1.6 ELF3 PKNOX1 ARID4B THRB RAD21 RFX5 ZNF143 MIXL1 DEK THAP11 RNASE7 ARHGEF40 NDRG2 ZNF219 METTL17 TMEM253 GC14M021020 GC14P021084
GH14H020997 1 Ensembl ENCODE 10.3 -43.5 -43541 2.9 SCRT1 STAT1 SP3 SMARCC1 SP2 KLF17 ZIC2 POLR2A ZNF629 SCRT2 SLC39A2 TPPP2 ENSG00000255472 RNASE13 ZNF219 TMEM253 RNASE7 LOC101929718 METTL17
GH14H021037 1.1 Ensembl ENCODE 5.9 -2.9 -2923 2.8 ELF3 ARID4B DMAP1 THRB RAD21 YY1 SLC30A9 MIXL1 SMARCA5 ZNF654 RNASE7 RNASE13
GH14H021043 1 ENCODE 5.8 +2.0 1950 2 FOXA2 DMAP1 YY1 GTF3C2 GATA2 ATF7 REST MIER2 PPARG NFIL3 METTL17 METTL3 PARP2 CHD8 SUPT16H PIP4P1 APEX1 NDRG2 ARHGEF40 ZNF219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASE7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RNASE7 Gene

Genomic Locations for RNASE7 Gene
chr14:21,042,226-21,044,234
(GRCh38/hg38)
Size:
2,009 bases
Orientation:
Plus strand
chr14:21,510,385-21,512,393
(GRCh37/hg19)

Genomic View for RNASE7 Gene

Genes around RNASE7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE7 Gene

Proteins for RNASE7 Gene

  • Protein details for RNASE7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1E1-RNAS7_HUMAN
    Recommended name:
    Ribonuclease 7
    Protein Accession:
    Q9H1E1
    Secondary Accessions:
    • P80927
    • P83685
    • Q546N3

    Protein attributes for RNASE7 Gene

    Size:
    156 amino acids
    Molecular mass:
    17419 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE7 Gene

neXtProt entry for RNASE7 Gene

Selected DME Specific Peptides for RNASE7 Gene

Q9H1E1:
  • LLLLLLGLWVA
  • CKDLNTFLH
  • LVPVHLD
  • LTSGKYPNCRYKE

Post-translational modifications for RNASE7 Gene

  • Glycosylation at isoforms=127
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE7 Gene

Gene Families for RNASE7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE7 Gene

Suggested Antigen Peptide Sequences for RNASE7 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1E1

UniProtKB/Swiss-Prot:

RNAS7_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE7: view

Function for RNASE7 Gene

Molecular function for RNASE7 Gene

UniProtKB/Swiss-Prot Function:
Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium.

Enzyme Numbers (IUBMB) for RNASE7 Gene

Gene Ontology (GO) - Molecular Function for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 20180804
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity IDA 12244054
genes like me logo Genes that share ontologies with RNASE7: view

Phenotypes for RNASE7 Gene

genes like me logo Genes that share phenotypes with RNASE7: view

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE7 Gene

Localization for RNASE7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE7 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 25075772
GO:0005737 cytoplasm IDA 25075772
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE7 Gene

Pathways & Interactions for RNASE7 Gene

genes like me logo Genes that share pathways with RNASE7: view

Pathways by source for RNASE7 Gene

3 Reactome pathways for RNASE7 Gene

Interacting Proteins for RNASE7 Gene

Gene Ontology (GO) - Biological Process for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019730 antimicrobial humoral response TAS --
GO:0019731 antibacterial humoral response IDA 23302724
GO:0042742 defense response to bacterium IEA --
GO:0045087 innate immune response NAS 12244054
GO:0050829 defense response to Gram-negative bacterium IDA 12244054
genes like me logo Genes that share ontologies with RNASE7: view

No data available for SIGNOR curated interactions for RNASE7 Gene

Drugs & Compounds for RNASE7 Gene

(1) Drugs for RNASE7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RNASE7: view

Transcripts for RNASE7 Gene

mRNA/cDNA for RNASE7 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE7 Gene

Ribonuclease, RNase A family, 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for RNASE7 Gene

GeneLoc Exon Structure for
RNASE7
ECgene alternative splicing isoforms for
RNASE7

Expression for RNASE7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE7 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.0), Skin - Sun Exposed (Lower leg) (x10.7), Vagina (x6.4), and Skin - Not Sun Exposed (Suprapubic) (x5.1).

Protein differential expression in normal tissues from HIPED for RNASE7 Gene

This gene is overexpressed in Cervix (60.3) and Urinary Bladder (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE7 Gene



Protein tissue co-expression partners for RNASE7 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE7 Gene:

RNASE7

SOURCE GeneReport for Unigene cluster for RNASE7 Gene:

Hs.525206

mRNA Expression by UniProt/SwissProt for RNASE7 Gene:

Q9H1E1-RNAS7_HUMAN
Tissue specificity: Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for RNASE7 Gene

  • Skin(4.6)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with RNASE7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE7 Gene

Orthologs for RNASE7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE7 33 34
  • 98.72 (n)
cow
(Bos Taurus)
Mammalia RNASE7 33
  • 79.27 (n)
-- 34
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 54 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RSFR 34
  • 29 (a)
ManyToMany
ANG 34
  • 28 (a)
ManyToMany
CL2 34
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
ManyToMany
-- 34
  • 25 (a)
ManyToMany
Species where no ortholog for RNASE7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE7 Gene

ENSEMBL:
Gene Tree for RNASE7 (if available)
TreeFam:
Gene Tree for RNASE7 (if available)

Paralogs for RNASE7 Gene

Paralogs for RNASE7 Gene

(6) SIMAP similar genes for RNASE7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE7: view

Variants for RNASE7 Gene

Sequence variations from dbSNP and Humsavar for RNASE7 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000754233 -- 21,044,137(+) AAGCG(A/G)TGAAC intron-variant, utr-variant-3-prime
rs1001789922 -- 21,040,621(+) ATGAC(C/G)TGGTC intron-variant, upstream-variant-2KB
rs1002733456 -- 21,040,956(+) GGCAG(A/G/T)GACTT intron-variant, upstream-variant-2KB
rs1002791703 -- 21,041,951(+) TTCTA(A/G)GCTGT intron-variant, upstream-variant-2KB
rs1003709252 -- 21,042,133(+) ATGTG(A/G)CCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE7 Gene

Variant ID Type Subtype PubMed ID
nsv832740 CNV gain 17160897
nsv826882 CNV gain 20364138
nsv428293 CNV gain+loss 18775914
nsv1039369 CNV loss 25217958

Variation tolerance for RNASE7 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE7 Gene

Disorders for RNASE7 Gene

Relevant External Links for RNASE7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE7

No disorders were found for RNASE7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE7 Gene

Publications for RNASE7 Gene

  1. Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. (PMID: 12527768) Zhang J … Rosenberg HF (Nucleic acids research 2003) 2 3 4 22 60
  2. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. (PMID: 12244054) Harder J … Schroder JM (The Journal of biological chemistry 2002) 2 3 4 22 60
  3. Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall. (PMID: 20180804) Torrent M … Boix E (The FEBS journal 2010) 3 22 60
  4. Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin. (PMID: 19919305) Zanger P … Gabrysch S (The Journal of infectious diseases 2009) 3 22 60
  5. RNase 7 contributes to the cutaneous defense against Enterococcus faecium. (PMID: 19641608) Köten B … Harder J (PloS one 2009) 3 22 60

Products for RNASE7 Gene

Sources for RNASE7 Gene

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