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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE6 Gene

protein-coding   GIFtS: 52
GCID: GC14P021249

Ribonuclease, RNase A Family, K6


(Previous symbol: RNS6)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, K61 2     Ribonuclease K62
RNS61 2 3     EC 3.1.27.-3
RNase K61 3     EC 3.1.278
RNasek62     EC 3.1.27.58

External Ids:    HGNC: 100481   Entrez Gene: 60392   Ensembl: ENSG000001694137   OMIM: 6019815   UniProtKB: Q930913   

Export aliases for RNASE6 gene to outside databases

Previous GC identifers: GC14P018621 GC14P015036 GC14P019239 GC14P020319 GC14P001370


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNASE6 Gene: 
RNASE6 (ribonuclease, RNase A family, k6) is a protein-coding gene. Diseases associated with RNASE6 include pancreatitis. GO annotations related to this gene include ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091
Function: May have a role in host defense




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE6 gene promoter:
         PPAR-gamma1   HSF2   Brachyury   PPAR-gamma2   LCR-F1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE6 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASE6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11

RNASE6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021249:  view genomic region     (about GC identifiers)

Start:
21,249,210 bp from pter      End:
21,250,626 bp from pter
Size:
1,417 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091 (See protein sequence)
Recommended Name: Ribonuclease K6 precursor  
Size: 150 amino acids; 17196 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for RNASE6: NX_Q93091

Explore proteomics data for RNASE6 at MOPED 

4/10 DME Specific Peptides for RNASE6 (Q93091) (see all 10)
 YPQCRYS  WFEIQHI  LVPVHLD  SFQNVAA 

RNASE6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RNASE6 Protein Expression
REFSEQ proteins: NP_005606.1  
ENSEMBL proteins: 
 ENSP00000302046  

Human Recombinant Protein Products for RNASE6: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for RNASE6
OriGene Custom MassSpec 
OriGene Custom Protein Services for RNASE6
GenScript Custom Purified and Recombinant Proteins Services for RNASE6
Novus Biologicals RNASE6 Protein
Novus Biologicals RNASE6 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for RNASE6 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

RNASE6 for ontologies           About GeneDecksing



RNASE6 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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OriGene Custom Antibody Services for RNASE6
GenScript Custom Superior Antibodies Services for RNASE6
Novus Biologicals RNASE6 Antibody
Abcam antibodies for RNASE6
Cloud-Clone Corp. Antibodies for RNASE6 
Search ThermoFisher Antibodies for RNASE6
LSBio Antibodies in human, mouse, rat for RNASE6 

Assay Products for RNASE6: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for RNASE6
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for RNASE6
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for RNASE6 
Cloud-Clone Corp. CLIAs for RNASE6


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNASE: Ribonucleases, RNase A

3 InterPro protein domains:
 IPR023411 RNaseA_AS
 IPR023412 RNaseA_domain
 IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry Q93091

ProtoNet protein and cluster: Q93091

1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091
Similarity: Belongs to the pancreatic ribonuclease family


RNASE6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RNAS6_HUMAN, Q93091
Function: May have a role in host defense

     Genatlas biochemistry entry for RNASE6:
ribonuclease RNAse A family,k6,ubiquitously expressed

     Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0004522pancreatic ribonuclease activity IEA--
GO:0004540ribonuclease activity TAS8836175
     
RNASE6 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE6 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE6 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASE6 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE6
1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASE6:
hsa-miR-137
SwitchGear 3'UTR luciferase reporter plasmidRNASE6 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for RNASE6
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE6

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RNASE6
Sirion Biotech Customized adenovirus for overexpression of RNASE6

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for RNASE6 (see all 7)
OriGene ORF clones in mouse, rat for RNASE6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6
Sirion Biotech Customized lentivirus for stable overexpression of RNASE6 
                     Customized lentivirus expression plasmids for stable overexpression of RNASE6 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RNASE6
Search LifeMap BioReagents cell lines for RNASE6
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE6

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RNASE6 (Q930912, 3 ENSP000003020464) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ARR3P365752, 3, ENSP000003115384MINT-64402 I2D: score=5 STRING: ENSP00000311538
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006401RNA catabolic process TAS8836175
GO:0006952defense response TAS8836175

RNASE6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RNASE6 for compounds           About GeneDecksing

EMD Millipore small molecules for RNASE6:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNASE6 (RNAS6)

1 Novoseek inferred chemical compound relationship for RNASE6 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
lysine 47 2 8836175 (1), 9647635 (1)

Search CenterWatch for drugs/clinical trials and news about RNASE6 / RNAS6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNASE6 gene: 
NM_005615.4  

Unigene Cluster for RNASE6:

Ribonuclease, RNase A family, k6
Hs.23262  [show with all ESTs]
Unigene Representative Sequence: BC020848
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000304677(uc001vye.4)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE6
1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASE6:
hsa-miR-137
SwitchGear 3'UTR luciferase reporter plasmidRNASE6 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for RNASE6
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE6
Clone
Products:
     
OriGene clones in human, mouse for RNASE6 (see all 7)
OriGene ORF clones in mouse, rat for RNASE6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6
Sirion Biotech Customized lentivirus for stable overexpression of RNASE6 
                     Customized lentivirus expression plasmids for stable overexpression of RNASE6 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RNASE6
OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASE6
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE6
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE6

Additional mRNA sequence: 

AK313580.1 BC020848.1 CR456965.1 

5 DOTS entries:

DT.453979  DT.91803171  DT.92419674  DT.92419675  DT.92419677 

24/89 AceView cDNA sequences (see all 89):

AW406516 AA456519 AI590889 AA312989 BP370537 BM920166 BM710423 CR456965 
BE466696 BP432143 AI523183 BE466877 BE858435 BQ006859 AI263505 AI142565 
BC020848 AI080148 CD678519 AI418898 AI378734 AA973893 CB242107 CD702355 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASE6 expression in normal human tissues (normalized intensities)      RNASE6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACTGACTGCA
RNASE6 Expression
About this image


RNASE6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Plasmacytoid Dendritic cells Peripheral Blood
         Peripheral Blood Immature Myeloid Dendritic Cells   
 
 Endothelium (Cardiovascular System)
         Peripheral blood-derived early endothelial progenitor cells
 
 Eye (Sensory Organs)
         Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

 -- (Gastrointestinal Tract)
         pharynx   

See RNASE6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASE6

SOURCE GeneReport for Unigene cluster: Hs.23262

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091
Tissue specificity: Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and
skeletal muscle. Also expressed in monocytes and neutrophils

    SABiosciences Custom PCR Arrays for RNASE6
Primer
Products:
OriGene qPCR primer pairs and template standards for RNASE6
OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASE6
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE6
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE6
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RNASE6 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnase61 , 5 ribonuclease, RNase A family, 61, 5 75.76(n)1
66.43(a)1
  14 (26.39 cM)5
784161  NM_030098.21  NP_084374.21 
 511290685 
chicken
(Gallus gallus)
Aves RSFR6
CL26
(see all 3)
Ribonuclease CL2
(see all 3)
24(a)
24(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
6(8804970-8806179)
4(49041665-49042706)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 3)
Uncharacterized protein
(see all 3)
27(a)
26(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
GL343220.1(1531632-1532063)
GL343220.1(1438299-1438661)


ENSEMBL Gene Tree for RNASE6 (if available)
TreeFam Gene Tree for RNASE6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RNASE6 gene
RNASE32  RNASE82  RNASE72  RNASE22  RNASE12  ANG2  RNASE42  
5 SIMAP similar genes for RNASE6 using alignment to 2 protein entries:     RNAS6_HUMAN (see all proteins):
RNASE7    RNASE8    RNASE2    RNASE1    RNASE3

RNASE6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/120 SNPs in RNASE6 are shown (see all 120)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs9861921,2
C,F,A,H--21247220(+) atgaaG/Atctaa 1 -- us2k120Minor allele frequency- A:0.36NS EA NA WA CSA 1743
rs791578581,2
C,F--21247294(+) TAACTT/ATTCTC 1 -- us2k11Minor allele frequency- A:0.03NA 120
rs128823031,2
C,F--21247394(+) tgtctA/Gttttt 1 -- us2k16Minor allele frequency- G:0.23NA WA EA 364
rs1890160241,2
--21247395(+) GTCTAC/TTTTTC 1 -- us2k10--------
rs1494441671,2
--21247412(+) AACACA/CCTGTC 1 -- us2k10--------
rs1446682121,2
C--21247414(+) CACACA/TGTCTT 1 -- us2k10--------
rs9861931,2
C,F--21247423(+) ttaatT/Cgctgt 1 -- us2k1 tfbs38Minor allele frequency- C:0.38WA NA CSA EA 367
rs128866881,2
C,F--21247475(+) tgactT/Ctgttc 1 -- us2k16Minor allele frequency- C:0.24NA WA EA 364
rs1383325631,2
--21247499(+) TTGTGA/TTGACT 1 -- us2k10--------
rs285481381,2
C,F--21247508(+) CTATTC/GTGAAT 1 -- us2k12Minor allele frequency- G:0.29NA EA 240

HapMap Linkage Disequilibrium report for RNASE6 (21249210 - 21250626 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RNASE6:    About this table     
Variant IDTypeSubtypePubMed ID
nsv428293CNV Gain+Loss18775914
esv23438CNV Gain+Loss19812545
dgv607e1CNV Complex17122850

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing RNASE6
DNA2.0 Custom Variant and Variant Library Synthesis for RNASE6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 601981    OMIM disorders: --

2 diseases for RNASE6:    About MalaCards
pancreatitis    


RNASE6 for disorders           About GeneDecksing

Genetic Association Database (GAD): RNASE6

Export disorders for RNASE6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RNASE6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNASE6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PubMed id 8836175)1, 2, 3, 9 Rosenberg H.F. and Dyer K.D. (1996)
  2. Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PubMed id 9647635)1, 3, 9 Deming M.S....Rosenberg H.F. (1998)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....Munafo M.R. (2010)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  6. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
  7. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1 Cho S.... Zhang J. (2005)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  9. Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus. (PubMed id 9826755)9 Domachowske J.B....Rosenberg H.F. (1998)
  10. Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity. (PubMed id 9649619)9 Domachowske J.B....Rosenberg H.F. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6039 HGNC: 10048 AceView: RNASE6 Ensembl:ENSG00000169413 euGenes: HUgn6039
ECgene: RNASE6 H-InvDB: RNASE6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RNASE6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RNASE6 gene:
Search GeneIP for patents involving RNASE6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
 Browse for Gene Knock-down Tools from EMD Millipore
 Browse Kits and Assays available from EMD Millipore
 EMD Millipore small molecules (inhibitor) for RNASE6
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
 
 EMD Millipore Custom Antibody & Bulk Services
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 Browse Antibodies   Browse Cell Culture Products  
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNASE6  
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 OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for RNASE6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for RNASE6   OriGene Custom Protein Services for RNASE6  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASE6
 QIAGEN SeqTarget long-range PCR primers for resequencing RNASE6
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE6
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE6
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE6
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE6
 GenScript Custom Purified and Recombinant Proteins Services for RNASE6 GenScript cDNA clones with any tag delivered in your preferred vector for RNASE6
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 GenScript Custom overexpressing Cell Line Services for RNASE6 CloneReady with Over 120,000 Genes
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 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
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 Search for Antibodies & Assays

 Regulatory tfbs in RNASE6 promoter
 Search Chromatin IP Primers for RNASE6
 RT2 qPCR Primer Assay in human, mouse, rat RNASE6
 Search GNC Networks for RNASE6
 SABiosciences Custom PCR Arrays for RNASE6
 Search Tocris compounds for RNASE6 (RNAS6)
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 RNASE6 antibodies
 RNASE6 proteins
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 Antibodies for RNASE6
 See all of Abcam's Antibodies, Kits and Proteins for RNASE6
 Custom Antibody / Protein Production Service
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 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Proteins for RNASE6
 Antibodies for RNASE6
 ELISAs for RNASE6
 CLIAs for RNASE6
 Search LifeMap BioReagents cell lines for RNASE6
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6
 SwitchGear 3'UTR luciferase reporter plasmids for RNASE6
 SwitchGear Promoter luciferase reporter plasmids for RNASE6
 Search ThermoFisher Antibodies for RNASE6
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6
 inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE6
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE6
Customized:
 lentivirus for stable overexpression of RNASE6
 lentivirus expression plasmids for stable overexpression of RNASE6
 adenovirus for overexpression of RNASE6
 LSBio Antibodies in human, mouse, rat for RNASE6
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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