Aliases for RNASE6 Gene
Aliases for RNASE6 Gene
External Ids for RNASE6 Gene
- HGNC: 10048
- Entrez Gene: 6039
- Ensembl: ENSG00000169413
- OMIM: 601981
- UniProtKB: Q93091
Previous HGNC Symbols for RNASE6 Gene
- RNS6
Previous GeneCards Identifiers for RNASE6 Gene
- GC14P018621
- GC14P015036
- GC14P019239
- GC14P020319
- GC14P021249
- GC14P001370
Summaries for RNASE6 Gene
-
The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]
GeneCards Summary for RNASE6 Gene
RNASE6 (Ribonuclease A Family Member K6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ANG.
UniProtKB/Swiss-Prot for RNASE6 Gene
-
May have a role in host defense.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE6 Gene
Genomics for RNASE6 Gene
Regulatory Elements for RNASE6 Gene
Enhancers for RNASE6 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around RNASE6 on UCSC Golden Path with GeneCards custom track
Promoters for RNASE6 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around RNASE6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the RNASE6 gene promoter:
Regulatory Element Products
Genomic Location for RNASE6 Gene
- Chromosome:
- 14
- Start:
- 20,781,051 bp from pter
- End:
- 20,782,467 bp from pter
- Size:
- 1,417 bases
- Orientation:
- Plus strand
Genomic View for RNASE6 Gene
Genes around RNASE6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11 by HGNC
RNASE6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNASE6 Gene
Proteins for RNASE6 Gene
-
Protein details for RNASE6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q93091-RNAS6_HUMAN
- Recommended name:
- Ribonuclease K6
- Protein Accession:
- Q93091
Protein attributes for RNASE6 Gene
- Size:
- 150 amino acids
- Molecular mass:
- 17196 Da
- Quaternary structure:
- No Data Available
Protein Expression for RNASE6 Gene
Selected DME Specific Peptides for RNASE6 Gene
Post-translational modifications for RNASE6 Gene
- Glycosylation at Asn 55 and Asn 100
Other Protein References for RNASE6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RNASE6
- Abcam antibodies for RNASE6
-
Cloud-Clone Corp. Antibodies for RNASE6
- antibodies-online Antibodies for RNASE6: See all 24
- Search GeneTex for Antibodies for RNASE6
-
Santa Cruz Biotechnology (SCBT) Antibodies for RNASE6
Protein Products
-
OriGene Purified Proteins for RNASE6
- Search Origene for MassSpec and Protein Over-expression Lysates for RNASE6
- Origene Custom Protein Services for RNASE6
-
Cloud-Clone Corp. Proteins for RNASE6
- antibodies-online Proteins for RNASE6: See all 18
- Search antibodies-online for peptides
- Search GeneTex for Proteins for RNASE6
- Abcam proteins for RNASE6
Domains & Families for RNASE6 Gene
Gene Families for RNASE6 Gene
Protein Domains for RNASE6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNASE6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q93091- Family:
-
- Belongs to the pancreatic ribonuclease family.
Function for RNASE6 Gene
Molecular function for RNASE6 Gene
- GENATLAS Biochemistry:
- ribonuclease RNAse A family,k6,ubiquitously expressed
- UniProtKB/Swiss-Prot Function:
- May have a role in host defense.
Enzyme Numbers (IUBMB) for RNASE6 Gene
- EC 3.1.27 63
- EC 3.1.27.5 63
- EC 3.1.27.- 4
Phenotypes for RNASE6 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for RNASE6
-
ViGene Biosciences lentiviral particle packaged cDNA for RNASE6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNASE6 gene
- Search ViGene Biosciences for RNASE6
CRISPR Products
-
OriGene CRISPR knockouts for RNASE6
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNASE6
- GenScript: Design CRISPR guide RNA sequences for RNASE6
miRNA for RNASE6 Gene
- miRTarBase miRNAs that target RNASE6
miRNA Products
- Search ViGene Biosciences for RNASE6
Clone Products
- OriGene clones in human for RNASE6
- OriGene ORF clones in human,mouse,rat for RNASE6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RNASE6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RNASE6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNASE6 gene
Flow Cytometry Products
No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE6 Gene
Localization for RNASE6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNASE6 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
No data available for Gene Ontology (GO) - Cellular Components for RNASE6 Gene
Pathways & Interactions for RNASE6 Gene
More details on SuperPathways for RNASE6
No Data Available
Interacting Proteins for RNASE6 Gene
Selected Interacting proteins:
Q93091-RNAS6_HUMAN
ENSP00000302046
for RNASE6 Gene via
MINT
STRING
I2D
| Symbol | External ID(s) | Details |
|---|---|---|
| ARR3 |
No data available for Pathways by source and SIGNOR curated interactions for RNASE6 Gene
Transcripts for RNASE6 Gene
mRNA/cDNA for RNASE6 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RNASE6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RNASE6
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNASE6
- GenScript: Design CRISPR guide RNA sequences for RNASE6
miRNA Products
- Search ViGene Biosciences for RNASE6
Clone Products
- OriGene clones in human for RNASE6
- OriGene ORF clones in human,mouse,rat for RNASE6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for RNASE6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
mRNA differential expression in normal tissues according to GTEx for RNASE6 Gene
This gene is overexpressed in Whole Blood (x16.0) and Spleen (x4.4).
This gene is overexpressed in Kidney (29.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE6 Gene
SOURCE GeneReport for Unigene cluster for RNASE6 Gene Hs.23262
mRNA Expression by UniProt/SwissProt for RNASE6 Gene
Q93091-RNAS6_HUMAN
Tissue specificity:
Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.
Primer Products
-
OriGene qPCR primer pairs for RNASE6
-
OriGene qPCR primer pairs and template standards for RNASE6
No data available for Protein tissue co-expression partners for RNASE6 Gene
Orthologs for RNASE6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | RNASE6 35 |
|
||
| RNASE6 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Rnase6 35 |
|
||
| Rnase6 16 |
|
||||
| Rnase6 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | RNASE6 35 |
|
||
| RNASE6 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Rnase6 35 |
|
||
| dog (Canis familiaris) |
Mammalia | RNASE6 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | ANG 36 |
|
ManyToMany | |
| CL2 36 |
|
ManyToMany | |||
| RSFR 36 |
|
ManyToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany |
- Species with no ortholog for RNASE6:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for RNASE6 Gene
(5) SIMAP similar genes for RNASE6 Gene using alignment to 2 proteins:
Variants for RNASE6 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1045922 | - | 20,781,965(+) | TCGTC(A/G)GCACA | reference, missense | |
| rs7150888 | -- | 20,782,517(+) | ACTCA(A/G)AGGAA | downstream-variant-500B | |
| rs7156801 | -- | 20,782,207(+) | ATCCA(C/T)GTTTT | utr-variant-3-prime | |
| rs986192 | -- | 20,779,061(+) | atgaa(A/G)tctaa | upstream-variant-2KB | |
| rs986193 | -- | 20,779,264(+) | ttaat(C/T)gctgt | upstream-variant-2KB |
Residual Variation Intolerance Score:
78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.90;
18.72% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNASE6 Gene
Disorders for RNASE6 Gene
Relevant External Links for RNASE6
No disorders were found for RNASE6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE6 Gene
Publications for RNASE6 Gene
- Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PMID: 8836175) Rosenberg H.F. … Dyer K.D. (Nucleic Acids Res. 1996) 2 3 4 23 67
- Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PMID: 9647635) Deming M.S. … Rosenberg H.F. (Genome Res. 1998) 2 3 23
- Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. (PMID: 25075772) Becknell B. … Spencer J.D. (Kidney Int. 2015) 3
- Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3
- Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
Products for RNASE6 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Browse Proteome Profiler Antibody Arrays
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- Browse OriGene Antibodies
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RNASE6
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- Origene Custom Protein Services for RNASE6
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for RNASE6
- Browse OriGene Inhibitory RNA Products For RNASE6
- OriGene qPCR primer pairs for RNASE6
- OriGene qPCR primer pairs and template standards for RNASE6
- OriGene CRISPR knockouts for RNASE6
- OriGene clones in human for RNASE6
- OriGene ORF clones in human,mouse,rat for RNASE6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
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- GenScript Custom Assay Services for RNASE6
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- GenScript: Design CRISPR guide RNA sequences for RNASE6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RNASE6
- Novus Biologicals Antibodies for RNASE6
- Novus Biologicals proteins and lysates for RNASE6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for RNASE6
- Abcam proteins for RNASE6
- Search for Assays for RNASE6 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for RNASE6
- Cloud-Clone Corp. Proteins for RNASE6
- Cloud-Clone Corp Assay Kits for RNASE6
- Taconic Biosciences Mouse Models for RNASE6
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for RNASE6: See all 24
- antibodies-online Kits for RNASE6: See all 4
- antibodies-online Proteins for RNASE6: See all 18
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for RNASE6
- Search GeneTex for Proteins for RNASE6
- ViGene Biosciences adenoviral particle packaged cDNA for RNASE6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RNASE6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RNASE6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RNASE6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RNASE6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RNASE6 gene
- Search ViGene Biosciences for RNASE6
- Search ViGene Biosciences for RNASE6
- Santa Cruz Biotechnology (SCBT) Antibodies for RNASE6
- Search Santa Cruz Biotechnology (SCBT) for RNASE6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RNASE6
Sources for RNASE6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
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- (137) MeSH
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- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon