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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNASE6 Gene

protein-coding GIFtS: 52
GCID: GC14P021249

Ribonuclease, RNase A Family, K6

(Previous symbol: RNS6)

1 related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, K6¹ ²		Ribonuclease K6²
RNS6¹ ² ³		EC 3.1.27.-³
RNase K6¹ ³		EC 3.1.27⁸
RNasek6²		EC 3.1.27.5⁸

External Ids:	HGNC: 10048¹	Entrez Gene: 6039²	Ensembl: ENSG00000169413⁷	OMIM: 601981⁵	UniProtKB: Q93091³

Export aliases for RNASE6 gene to outside databases

Previous GC identifers: GC14P018621 GC14P015036 GC14P019239 GC14P020319 GC14P001370

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNASE6 Gene:

RNASE6 (ribonuclease, RNase A family, k6) is a protein-coding gene. Diseases associated with RNASE6 include pancreatitis. GO annotations related to this gene include ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091

Function: May have a role in host defense

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.2 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNASE6 gene promoter:
PPAR-gamma1 HSF2 Brachyury PPAR-gamma2 LCR-F1 Zic3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASE6 promoter sequence

Search SABiosciences Chromatin IP Primers for RNASE6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11

RNASE6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE6 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P021249: view genomic region (about GC identifiers)

Start:	21,249,210 bp from pter	End:	21,250,626 bp from pter
Size:	1,417 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091 (See protein sequence)

Recommended Name: Ribonuclease K6 precursor

Size: 150 amino acids; 17196 Da

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for RNASE6: NX_Q93091

Explore proteomics data for RNASE6 at MOPED

4/10 DME Specific Peptides for RNASE6 (Q93091) (see all 10)

YPQCRYS

WFEIQHI

LVPVHLD

SFQNVAA

RNASE6 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_005606.1

ENSEMBL proteins:

ENSP00000302046

Human Recombinant Protein Products for RNASE6:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals RNASE6 Protein Novus Biologicals RNASE6 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RNASE6

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

RNASE6 for ontologies About GeneDecksing

RNASE6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for RNASE6
	Novus Biologicals RNASE6 Antibody
	Abcam antibodies for RNASE6
	Cloud-Clone Corp. Antibodies for RNASE6
	Search ThermoFisher Antibodies for RNASE6
	LSBio Antibodies in human, mouse, rat for RNASE6

Assay Products for RNASE6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RNASE6
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RNASE6
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RNASE6 Cloud-Clone Corp. CLIAs for RNASE6

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

RNASE: Ribonucleases, RNase A

3 InterPro protein domains:

IPR023411 RNaseA_AS

IPR023412 RNaseA_domain

IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry Q93091

ProtoNet protein and cluster: Q93091

1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091

Similarity: Belongs to the pancreatic ribonuclease family

RNASE6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RNAS6_HUMAN, Q93091

Function: May have a role in host defense

Genatlas biochemistry entry for RNASE6:

ribonuclease RNAse A family,k6,ubiquitously expressed

Enzyme Numbers (IUBMB): EC 3.1.27.5² EC 3.1.27² EC 3.1.27.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0004522	pancreatic ribonuclease activity	IEA	--
GO:0004540	ribonuclease activity	TAS	8836175

RNASE6 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE6

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE6

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE6
		1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASE6:
		hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: RNASE6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RNASE6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE6
		Sirion Biotech Custom design and validation of potent shRNA sequences against RNASE6

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RNASE6
			Sirion Biotech Customized adenovirus for overexpression of RNASE6 Customized adenovirus for potent knockdown of RNASE6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for RNASE6 (see all 7) OriGene ORF clones in mouse, rat for RNASE6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RNASE6
		Search LifeMap BioReagents cell lines for RNASE6
		Sirion Biotech Customized stable knockdown cell line services for RNASE6 Customized inducible knockdown cell line services for RNASE6 Customized stable overexpressing cell line services for RNASE6 Customized inducible overexpressing cell line services for RNASE6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNASE6

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RNASE6 (Q93091^{2, 3} ENSP00000302046⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARR3	P36575²^,³, ENSP00000311538⁴	MINT-64402 I2D: score=5 STRING: ENSP00000311538

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006401	RNA catabolic process	TAS	8836175
GO:0006952	defense response	TAS	8836175

RNASE6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RNASE6 for compounds About GeneDecksing

EMD Millipore small molecules for RNASE6:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNASE6 (RNAS6)

1 Novoseek inferred chemical compound relationship for RNASE6 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	47	2	8836175 (1), 9647635 (1)

Search CenterWatch for drugs/clinical trials and news about RNASE6 / RNAS6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNASE6 gene:

NM_005615.4

Unigene Cluster for RNASE6:

Ribonuclease, RNase A family, k6

Hs.23262 [show with all ESTs]

Unigene Representative Sequence: BC020848

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000304677(uc001vye.4)

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE6
		1 QIAGEN miScript miRNA Assays for microRNA that regulate RNASE6:
		hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: RNASE6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for RNASE6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE6
		Sirion Biotech Custom design and validation of potent shRNA sequences against RNASE6

Clone Products:		OriGene clones in human, mouse for RNASE6 (see all 7) OriGene ORF clones in mouse, rat for RNASE6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6

Primer Products:		OriGene qPCR primer pairs and template standards for RNASE6 OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RNASE6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE6

Additional mRNA sequence:

AK313580.1 BC020848.1 CR456965.1

5 DOTS entries:

DT.453979 DT.91803171 DT.92419674 DT.92419675 DT.92419677

24/89 AceView cDNA sequences (see all 89):

AW406516 AA456519 AI590889 AA312989 BP370537 BM920166 BM710423 CR456965

BE466696 BP432143 AI523183 BE466877 BE858435 BQ006859 AI263505 AI142565

BC020848 AI080148 CD678519 AI418898 AI378734 AA973893 CB242107 CD702355

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASE6 expression in normal human tissues (normalized intensities) RNASE6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACTGACTGCA

About this image

RNASE6 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/1 selected tissues (see all 1) fully expand


Eye (Sensory Organs)
Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

-- (Gastrointestinal Tract)
pharynx

See RNASE6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASE6

SOURCE GeneReport for Unigene cluster: Hs.23262

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091

Tissue specificity: Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal

muscle. Also expressed in monocytes and neutrophils

SABiosciences Custom PCR Arrays for RNASE6

Primer Products:		OriGene qPCR primer pairs and template standards for RNASE6 OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RNASE6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RNASE6 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnase6^{1 , 5}	ribonuclease, RNase A family, 6^{1, 5}	75.76(n)¹ 66.43(a)¹		14 (26.39 cM)⁵ 78416¹ NM_030098.2¹ NP_084374.2¹ 51129068⁵
chicken (Gallus gallus)	Aves	RSFR⁶ CL2⁶ (see all 3)	Ribonuclease CL2 (see all 3)	24(a) 24(a) (see all 3)	many ↔ many many ↔ many (see all 3)	6(8804970-8806179) 4(49041665-49042706)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	Uncharacterized protein (see all 3)	27(a) 26(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343220.1(1531632-1532063) GL343220.1(1438299-1438661)

ENSEMBL Gene Tree for RNASE6 (if available)
TreeFam Gene Tree for RNASE6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNASE6 gene

RNASE3² RNASE8² RNASE7² RNASE2² RNASE1² ANG² RNASE4²

5 SIMAP similar genes for RNASE6 using alignment to 2 protein entries: RNAS6_HUMAN (see all proteins):

RNASE7 RNASE8 RNASE2 RNASE1 RNASE3

RNASE6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs986192^1,2	C,F,A,H	--	21247220(+)	`atgaaG/Atctaa`	1	--	us2k¹		20		NS EA NA WA CSA	1743
rs79157858^1,2	C,F	--	21247294(+)	`TAACTT/ATTCTC`	1	--	us2k¹		1		NA	120
rs12882303^1,2	C,F	--	21247394(+)	`tgtctA/Gttttt`	1	--	us2k¹		6		NA WA EA	364
rs189016024^1,2		--	21247395(+)	`GTCTAC/TTTTTC`	1	--	us2k¹		0	--	--	--	--
rs149444167^1,2		--	21247412(+)	`AACACA/CCTGTC`	1	--	us2k¹		0	--	--	--	--
rs144668212^1,2	C	--	21247414(+)	`CACACA/TGTCTT`	1	--	us2k¹		0	--	--	--	--
rs986193^1,2	C,F	--	21247423(+)	`ttaatT/Cgctgt`	1	--	us2k¹ tfbs³		8		WA NA CSA EA	367
rs12886688^1,2	C,F	--	21247475(+)	`tgactT/Ctgttc`	1	--	us2k¹		6		NA WA EA	364
rs138332563^1,2		--	21247499(+)	`TTGTGA/TTGACT`	1	--	us2k¹		0	--	--	--	--
rs28548138^1,2	C,F	--	21247508(+)	`CTATTC/GTGAAT`	1	--	us2k¹		2		NA EA	240

HapMap Linkage Disequilibrium report for RNASE6 (21249210 - 21250626 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RNASE6: About this table

Variant ID	Type	Subtype	PubMed ID
nsv428293	CNV	Gain+Loss	18775914
esv23438	CNV	Gain+Loss	19812545
dgv607e1	CNV	Complex	17122850

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE6

DNA2.0 Custom Variant and Variant Library Synthesis for RNASE6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNASE6 for disorders           About GeneDecksing

OMIM gene information: 601981    OMIM disorders: --

2 diseases for RNASE6:    About MalaCards

pancreatitis

Genetic Association Database (GAD): RNASE6

Export disorders for RNASE6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNASE6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNASE6)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PubMed id 8836175)^{1, 2, 3, 9} Rosenberg H.F. and Dyer K.D. (1996)
Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PubMed id 9647635)^{1, 3, 9} Deming M.S....Rosenberg H.F. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)⁴ Uhl G.R....Munafo M.R. (2010)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)¹ Cho S.... Zhang J. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus. (PubMed id 9826755)⁹ Domachowske J.B....Rosenberg H.F. (1998)
Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity. (PubMed id 9649619)⁹ Domachowske J.B....Rosenberg H.F. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6039	HGNC: 10048	AceView: RNASE6	Ensembl:ENSG00000169413	euGenes: HUgn6039
ECgene: RNASE6	H-InvDB: RNASE6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNASE6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNASE6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RNASE6 gene:
Search GeneIP for patents involving RNASE6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse for Gene Knock-down Tools from EMD Millipore
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	EMD Millipore small molecules (inhibitor) for RNASE6
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	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for RNASE6
	OriGene qPCR primer pairs and template standards for RNASE6		OriGene Protein Over-expression Lysate for RNASE6
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	OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for RNASE6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RNASE6		OriGene Custom Protein Services for RNASE6

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASE6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE6

	GenScript Custom Purified and Recombinant Proteins Services for RNASE6		GenScript cDNA clones with any tag delivered in your preferred vector for RNASE6
	GenScript Custom Assay Services for RNASE6		GenScript Custom Superior Antibodies Services for RNASE6
	GenScript Custom overexpressing Cell Line Services for RNASE6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in RNASE6 promoter
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Search Tocris compounds for RNASE6 (RNAS6)

	Browse Sino Biological Proteins and Antibodies
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	Protein Production Services
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RNASE6 antibodies
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	RNASE6 lysates

	Antibodies for RNASE6
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Browse ProSpec Recombinant Proteins

	Proteins for RNASE6
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Search LifeMap BioReagents cell lines for RNASE6

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6

	SwitchGear 3'UTR luciferase reporter plasmids for RNASE6
	SwitchGear Promoter luciferase reporter plasmids for RNASE6

Search ThermoFisher Antibodies for RNASE6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6

	inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE6
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE6

Customized:

	stable knockdown cell line services for RNASE6
	inducible knockdown cell line services for RNASE6
	design and validation of potent shRNA sequences against RNASE6
	adenovirus for potent knockdown of RNASE6
	stable overexpressing cell line services for RNASE6
	inducible overexpressing cell line services for RNASE6
	adenovirus for overexpression of RNASE6

LSBio Antibodies in human, mouse, rat for RNASE6

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RNASE6 gene at Home site.

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RNASE6 Gene

Ribonuclease, RNase A Family, K6

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RNASE6 Gene

Ribonuclease, RNase A Family, K6

Aliasesfor RNASE6 gene

Summariesfor RNASE6 gene

Genomic Viewsfor RNASE6 gene

Proteinsfor RNASE6 gene

Protein Domains /Familiesfor RNASE6 gene

Functionfor RNASE6 gene

Pathways & Interactionsfor RNASE6 gene

Drugs & Compoundsfor RNASE6 gene

Transcriptsfor RNASE6 gene

Expression for RNASE6 gene

Orthologsfor RNASE6 gene

Paralogsfor RNASE6 gene

Genomic Variantsfor RNASE6 gene

Disorders / Diseasesfor RNASE6 gene

Publicationsfor RNASE6 gene

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Genome Databases showing RNASE6 gene

Other Databases showing RNASE6 gene

Specialized Databases showing RNASE6 gene

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Aliases
for RNASE6 gene

Summaries
for RNASE6 gene

Genomic Views
for RNASE6 gene

Proteins
for RNASE6 gene

Protein Domains /
Families
for RNASE6 gene

Function
for RNASE6 gene

Pathways & Interactions
for RNASE6 gene

Drugs & Compounds
for RNASE6 gene

Transcripts
for RNASE6 gene

Expression
for RNASE6 gene

Orthologs
for RNASE6 gene

Paralogs
for RNASE6 gene

Genomic Variants
for RNASE6 gene

Disorders / Diseases
for RNASE6 gene

Publications
for RNASE6 gene

Intellectual Property
for RNASE6 gene

Products
for RNASE6 gene