RNASE6 Gene

Aliases
for RNASE6 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC14P018621 GC14P015036 GC14P019239 GC14P020319 GC14P001370

Summaries
for RNASE6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for RNASE6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000014.8  NC_018925.2  NT_026437.13  

SwitchGear Promoter luciferase reporter plasmid: RNASE6 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE6

RNASE6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021249:  view genomic region     (about GC identifiers)

Proteins
for RNASE6 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for RNASE6: NX_Q93091

Explore proteomics data for RNASE6 at MOPED

Post-translational modifications: 

RNASE6 Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for RNASE6
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	Search GeneTex for Proteins for RNASE6
	antibodies-online proteins for RNASE6 (20 products)
	antibodies-online peptides for RNASE6

RNASE6 Antibody Products:

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	antibodies-online antibodies for RNASE6 (11 products)

RNASE6 Assay Products:

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	Cloud-Clone Corp. ELISAs for RNASE6 Cloud-Clone Corp. CLIAs for RNASE6
	Search eBioscience for ELISAs for RNASE6
	antibodies-online kits for RNASE6 (10 products)

Domains /
Families
for RNASE6 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q93091

Find genes that share domains with RNASE6           About GenesLikeMe

Function
for RNASE6 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for RNASE6

miRNA Products:		miRTarBase miRNAs that target RNASE6: hsa-mir-26b-5p (MIRT030200)
		Block miRNA regulation of human, mouse, rat RNASE6 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate RNASE6:
		hsa-miR-137
		SwitchGear 3'UTR luciferase reporter plasmid: RNASE6 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RNASE6
		Predesigned siRNA for gene silencing in human, mouse, rat RNASE6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RNASE6

Clone Products:		OriGene clones in human, mouse for RNASE6 (see all 7) OriGene ORF clones in mouse, rat for RNASE6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RNASE6
		Browse ESI BIO Cell Lines and PureStem Progenitors for RNASE6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6

Localization
for RNASE6 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for RNASE6 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RNASE6

	DNA Repair Mechanisms
	Chks in Checkpoint Regulation
	DNA Damage Induced 14-3-3Sigma Signaling

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for RNASE6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for RNASE6 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for RNASE6 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNASE6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ACTGACTGCA

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Epithelial Cells
Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
Blood (Hematopoietic System)
Plasmacytoid Dendritic cells Peripheral Blood
Eye (Sensory Organs)
Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

Primer Products:		OriGene qPCR primer pairs and template standards for RNASE6 OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE6
		QuantiTect SYBR Green Assays in human, mouse, rat RNASE6
		QuantiFast Probe-based Assays in human, mouse, rat RNASE6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6

Orthologs
for RNASE6 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for RNASE6 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for RNASE6 gene

RNASE3²  RNASE8²  RNASE7²  RNASE2²  RNASE1²  ANG²  RNASE4²  

5 SIMAP similar genes for RNASE6 using alignment to 2 protein entries:     RNAS6_HUMAN (see all proteins):

RNASE7    RNASE8    RNASE2    RNASE1    RNASE3

Find genes that share paralogs with RNASE6           About GenesLikeMe

Genomic Variants
for RNASE6 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RNASE6 (see all 120)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs9861921,2	C,F,A,H	--	21247220(+)	atgaaG/Atctaa	1	--	us2k1		20		NS EA NA WA CSA	1743
rs791578581,2	C,F	--	21247294(+)	TAACTT/ATTCTC	1	--	us2k1		1		NA	120
rs128823031,2	C,F	--	21247394(+)	tgtctA/Gttttt	1	--	us2k1		6		NA WA EA	364
rs1890160241,2		--	21247395(+)	GTCTAC/TTTTTC	1	--	us2k1		0	--	--	--	--
rs1494441671,2		--	21247412(+)	AACACA/CCTGTC	1	--	us2k1		0	--	--	--	--
rs1446682121,2	C	--	21247414(+)	CACACA/TGTCTT	1	--	us2k1		0	--	--	--	--
rs9861931,2	C,F	--	21247423(+)	ttaatT/Cgctgt	1	--	us2k1 tfbs3		8		WA NA CSA EA	367
rs128866881,2	C,F	--	21247475(+)	tgactT/Ctgttc	1	--	us2k1		6		NA WA EA	364
rs1383325631,2		--	21247499(+)	TTGTGA/TTGACT	1	--	us2k1		0	--	--	--	--
rs285481381,2	C,F	--	21247508(+)	CTATTC/GTGAAT	1	--	us2k1		2		NA EA	240

HapMap Linkage Disequilibrium report for RNASE6 (21249210 - 21250626 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RNASE6:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv428293	CNV	Gain+Loss	18775914
esv23438	CNV	Gain+Loss	19812545
dgv607e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RNASE6

DNA2.0 Custom Variant and Variant Library Synthesis for RNASE6

Disorders / Diseases
for RNASE6 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for RNASE6 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PubMed id 8836175)^{1, 2, 3, 9} Rosenberg H.F. and Dyer K.D. (Nucleic Acids Res. 1996)
2. Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PubMed id 9647635)^{1, 3, 9} Deming M.S....Rosenberg H.F. (Genome Res. 1998)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
4. Comparative genomic analysis of eutherian ribonuclease A genes. (PubMed id 24337645)¹ Premzl M. (Mol. Genet. Genomics 2014)
5. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)⁴ Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (Genomics 2007)
7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (Cell 2005)
8. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)¹ Cho S.... Zhang J. (Genomics 2005)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
10. Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus. (PubMed id 9826755)⁹ Domachowske J.B....Rosenberg H.F. (Nucleic Acids Res. 1998)

External Searches for RNASE6 gene

Genome Databases showing RNASE6 gene

Other Databases showing RNASE6 gene

Specialized Databases showing RNASE6 gene

Products
for RNASE6 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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