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Aliases for RNASE6 Gene

Aliases for RNASE6 Gene

  • Ribonuclease A Family Member K6 2 3
  • Ribonuclease, RNase A Family, K6 2 3 5
  • RNase K6 2 4
  • RNS6 3 4
  • Testicular Tissue Protein Li 166 3
  • Ribonuclease A D1 3
  • EC 63
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • RNasek6 3
  • RAD1 3

External Ids for RNASE6 Gene

Previous HGNC Symbols for RNASE6 Gene

  • RNS6

Previous GeneCards Identifiers for RNASE6 Gene

  • GC14P018621
  • GC14P015036
  • GC14P019239
  • GC14P020319
  • GC14P021249
  • GC14P001370

Summaries for RNASE6 Gene

Entrez Gene Summary for RNASE6 Gene

  • The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

GeneCards Summary for RNASE6 Gene

RNASE6 (Ribonuclease A Family Member K6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE6 Gene

  • May have a role in host defense.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE6 Gene

Genomics for RNASE6 Gene

Regulatory Elements for RNASE6 Gene

Enhancers for RNASE6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNASE6 on UCSC Golden Path with GeneCards custom track

Promoters for RNASE6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNASE6 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE6 Gene

20,781,051 bp from pter
20,782,467 bp from pter
1,417 bases
Plus strand

Genomic View for RNASE6 Gene

Genes around RNASE6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE6 Gene

Proteins for RNASE6 Gene

  • Protein details for RNASE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease K6
    Protein Accession:

    Protein attributes for RNASE6 Gene

    150 amino acids
    Molecular mass:
    17196 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE6 Gene

Proteomics data for RNASE6 Gene at MOPED

Post-translational modifications for RNASE6 Gene

  • Glycosylation at Asn 55 and Asn 100

Other Protein References for RNASE6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE6 Gene

Gene Families for RNASE6 Gene

Protein Domains for RNASE6 Gene

Suggested Antigen Peptide Sequences for RNASE6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE6: view

Function for RNASE6 Gene

Molecular function for RNASE6 Gene

GENATLAS Biochemistry:
ribonuclease RNAse A family,k6,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May have a role in host defense.

Enzyme Numbers (IUBMB) for RNASE6 Gene

genes like me logo Genes that share phenotypes with RNASE6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNASE6

miRNA for RNASE6 Gene

miRTarBase miRNAs that target RNASE6

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE6 Gene

Localization for RNASE6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE6 Gene


Subcellular locations from

Jensen Localization Image for RNASE6 Gene COMPARTMENTS Subcellular localization image for RNASE6 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for RNASE6 Gene

Pathways & Interactions for RNASE6 Gene

SuperPathways for RNASE6 Gene

No Data Available

Interacting Proteins for RNASE6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q93091-RNAS6_HUMAN ENSP00000302046 for RNASE6 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for RNASE6 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNASE6 Gene

Drugs & Compounds for RNASE6 Gene

(1) Drugs for RNASE6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RNASE6: view

Transcripts for RNASE6 Gene

mRNA/cDNA for RNASE6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE6 Gene

Ribonuclease, RNase A family, k6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE6 Gene

No ASD Table

Relevant External Links for RNASE6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE6 Gene

mRNA expression in normal human tissues for RNASE6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE6 Gene

This gene is overexpressed in Whole Blood (x16.0) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for RNASE6 Gene

This gene is overexpressed in Kidney (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE6 Gene

SOURCE GeneReport for Unigene cluster for RNASE6 Gene Hs.23262

mRNA Expression by UniProt/SwissProt for RNASE6 Gene

Tissue specificity: Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.
genes like me logo Genes that share expression patterns with RNASE6: view

Primer Products

No data available for Protein tissue co-expression partners for RNASE6 Gene

Orthologs for RNASE6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNASE6 35
  • 79.32 (n)
  • 70.8 (a)
  • 68 (a)
(Mus musculus)
Mammalia Rnase6 35
  • 76.23 (n)
  • 65.44 (a)
Rnase6 16
Rnase6 36
  • 64 (a)
(Pan troglodytes)
Mammalia RNASE6 35
  • 99.56 (n)
  • 99.33 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rnase6 35
  • 75.25 (n)
  • 63.97 (a)
(Canis familiaris)
Mammalia RNASE6 36
  • 44 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
(Gallus gallus)
Aves ANG 36
  • 23 (a)
CL2 36
  • 23 (a)
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
-- 36
  • 26 (a)
Species with no ortholog for RNASE6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE6 Gene

Gene Tree for RNASE6 (if available)
Gene Tree for RNASE6 (if available)

Paralogs for RNASE6 Gene

Paralogs for RNASE6 Gene

(5) SIMAP similar genes for RNASE6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE6: view

Variants for RNASE6 Gene

Sequence variations from dbSNP and Humsavar for RNASE6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1045922 - 20,781,965(+) TCGTC(A/G)GCACA reference, missense
rs7150888 -- 20,782,517(+) ACTCA(A/G)AGGAA downstream-variant-500B
rs7156801 -- 20,782,207(+) ATCCA(C/T)GTTTT utr-variant-3-prime
rs986192 -- 20,779,061(+) atgaa(A/G)tctaa upstream-variant-2KB
rs986193 -- 20,779,264(+) ttaat(C/T)gctgt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE6 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
dgv607e1 CNV Complex 17122850
nsv428293 CNV Gain+Loss 18775914

Variation tolerance for RNASE6 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNASE6 Gene

Disorders for RNASE6 Gene

Relevant External Links for RNASE6

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNASE6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE6 Gene

Publications for RNASE6 Gene

  1. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PMID: 8836175) Rosenberg H.F. … Dyer K.D. (Nucleic Acids Res. 1996) 2 3 4 23 67
  2. Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PMID: 9647635) Deming M.S. … Rosenberg H.F. (Genome Res. 1998) 2 3 23
  3. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. (PMID: 25075772) Becknell B. … Spencer J.D. (Kidney Int. 2015) 3
  4. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for RNASE6 Gene

Sources for RNASE6 Gene