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Aliases for RNASE6 Gene

Aliases for RNASE6 Gene

  • Ribonuclease A Family Member K6 2 3 5
  • Ribonuclease, RNase A Family, K6 2 3
  • RNase K6 2 4
  • RNS6 3 4
  • Testicular Tissue Protein Li 166 3
  • Ribonuclease A D1 3
  • Ribonuclease K6 3
  • EC 3.1.27.5 61
  • EC 3.1.27.- 4
  • EC 3.1.27 61
  • RNasek6 3
  • RAD1 3

External Ids for RNASE6 Gene

Previous HGNC Symbols for RNASE6 Gene

  • RNS6

Previous GeneCards Identifiers for RNASE6 Gene

  • GC14P018621
  • GC14P015036
  • GC14P019239
  • GC14P020319
  • GC14P021249
  • GC14P001370

Summaries for RNASE6 Gene

Entrez Gene Summary for RNASE6 Gene

  • The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

GeneCards Summary for RNASE6 Gene

RNASE6 (Ribonuclease A Family Member K6) is a Protein Coding gene. Among its related pathways are Innate Immune System and Defensins. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE7.

UniProtKB/Swiss-Prot for RNASE6 Gene

  • May have a role in host defense.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE6 Gene

Genomics for RNASE6 Gene

Regulatory Elements for RNASE6 Gene

Enhancers for RNASE6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G020714 1.3 FANTOM5 Ensembl ENCODE 16.9 -65.6 -65645 2.5 CTCF NFIB FEZF1 ZEB2 ZNF394 ZIC2 OSR2 RBAK IKZF1 SCRT2 EDDM3A RNASE6 EDDM3B RNASE1 ANG ARHGEF40 PNP TEP1 TMEM55B ENSG00000258451
GH14G020819 1.4 Ensembl ENCODE dbSUPER 11.1 +40.1 40141 2.6 HDAC1 TBP ATF1 CBX3 ARNT NFRKB CHAMP1 TCF12 CBX5 SMAD5 EDDM3B RNASE6 SUPT16H CHD8 APEX1 GC14P020814 ENSG00000259130
GH14G020719 0.5 ENCODE 15 -61.1 -61126 1.3 ZNF217 CTBP1 GATA3 DPF2 RNASE6 EDDM3A EDDM3B RNASE1 ANG PIR39681 GC14M020723 ENSG00000258451
GH14G021068 1.6 FANTOM5 ENCODE dbSUPER 2.3 +290.0 289994 5.0 HDGF ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF143 FOS PAF1 ZNF263 ARHGEF40 SUPT16H METTL3 SALL2 TMEM253 ZNF219 RNASE7 TPPP2 ENSG00000255472 RNASE13
GH14G020426 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -352.9 -352944 2.7 NFIB ARID4B EGR1 FOS RELB ETV6 IKZF2 CREM SMARCA5 SP5 OSGEP PNP TMEM55B APEX1 RNASE11 TEP1 KLHL33 RNASE6 RNASE3 GC14P020415
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASE6 on UCSC Golden Path with GeneCards custom track

Promoters for RNASE6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066403 549 401 PAF1 PKNOX1 ZNF362 CEBPB ZNF48 EED NBN ETV6
ENSR00000273607 1249 201 PAF1 MTA2 JUNB ZNF48 ZBTB40 MAFF ZNF316 IKZF1 MAFK SPI1

Genomic Location for RNASE6 Gene

Chromosome:
14
Start:
20,781,051 bp from pter
End:
20,782,467 bp from pter
Size:
1,417 bases
Orientation:
Plus strand

Genomic View for RNASE6 Gene

Genes around RNASE6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE6 Gene

Proteins for RNASE6 Gene

  • Protein details for RNASE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93091-RNAS6_HUMAN
    Recommended name:
    Ribonuclease K6
    Protein Accession:
    Q93091

    Protein attributes for RNASE6 Gene

    Size:
    150 amino acids
    Molecular mass:
    17196 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE6 Gene

neXtProt entry for RNASE6 Gene

Selected DME Specific Peptides for RNASE6 Gene

Q93091:
  • QNTFLHDSFQ
  • WFEIQHI
  • YPQCRYS
  • LVPVHLD
  • PPQKSDPPY
  • HNCHQSSKPVNMTDCRL
  • NNYTQHCK
  • AHWFEIQHIQPSPLQCNRAM
  • SFQNVAA
  • IQHIQPSPLQ

Post-translational modifications for RNASE6 Gene

  • Glycosylation at isoforms=55 and Asn100

Other Protein References for RNASE6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE6 Gene

Gene Families for RNASE6 Gene

Protein Domains for RNASE6 Gene

Suggested Antigen Peptide Sequences for RNASE6 Gene

Graphical View of Domain Structure for InterPro Entry

Q93091

UniProtKB/Swiss-Prot:

RNAS6_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE6: view

Function for RNASE6 Gene

Molecular function for RNASE6 Gene

GENATLAS Biochemistry:
ribonuclease RNAse A family,k6,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May have a role in host defense.

Enzyme Numbers (IUBMB) for RNASE6 Gene

Gene Ontology (GO) - Molecular Function for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity TAS 8836175
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RNASE6: view
genes like me logo Genes that share phenotypes with RNASE6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNASE6

CRISPR Products

miRNA for RNASE6 Gene

miRTarBase miRNAs that target RNASE6

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE6 Gene

Localization for RNASE6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE6 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE6: view

Pathways & Interactions for RNASE6 Gene

genes like me logo Genes that share pathways with RNASE6: view

Pathways by source for RNASE6 Gene

3 Reactome pathways for RNASE6 Gene

Interacting Proteins for RNASE6 Gene

Gene Ontology (GO) - Biological Process for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process TAS 8836175
GO:0006952 defense response TAS 8836175
GO:0019730 antimicrobial humoral response TAS --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RNASE6: view

No data available for SIGNOR curated interactions for RNASE6 Gene

Drugs & Compounds for RNASE6 Gene

(1) Drugs for RNASE6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RNASE6: view

Transcripts for RNASE6 Gene

mRNA/cDNA for RNASE6 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(89) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE6 Gene

Ribonuclease, RNase A family, k6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE6 Gene

No ASD Table

Relevant External Links for RNASE6 Gene

GeneLoc Exon Structure for
RNASE6
ECgene alternative splicing isoforms for
RNASE6

Expression for RNASE6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE6 Gene

This gene is overexpressed in Whole Blood (x16.0) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for RNASE6 Gene

This gene is overexpressed in Kidney (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE6 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNASE6 Gene:

RNASE6

SOURCE GeneReport for Unigene cluster for RNASE6 Gene:

Hs.23262

mRNA Expression by UniProt/SwissProt for RNASE6 Gene:

Q93091-RNAS6_HUMAN
Tissue specificity: Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils.
genes like me logo Genes that share expression patterns with RNASE6: view

Primer Products

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE6 Gene

Orthologs for RNASE6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE6 34 35
  • 99.56 (n)
cow
(Bos Taurus)
Mammalia RNASE6 34 35
  • 79.32 (n)
mouse
(Mus musculus)
Mammalia Rnase6 34 16 35
  • 76.23 (n)
rat
(Rattus norvegicus)
Mammalia Rnase6 34
  • 75.25 (n)
dog
(Canis familiaris)
Mammalia RNASE6 35
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 22 (a)
ManyToMany
chicken
(Gallus gallus)
Aves RSFR 35
  • 24 (a)
ManyToMany
ANG 35
  • 23 (a)
ManyToMany
CL2 35
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 26 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
Species where no ortholog for RNASE6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE6 Gene

ENSEMBL:
Gene Tree for RNASE6 (if available)
TreeFam:
Gene Tree for RNASE6 (if available)

Paralogs for RNASE6 Gene

Paralogs for RNASE6 Gene

(5) SIMAP similar genes for RNASE6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE6: view

Variants for RNASE6 Gene

Sequence variations from dbSNP and Humsavar for RNASE6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000970376 -- 20,780,067(+) AAAGC(A/G)TGGGG intron-variant, upstream-variant-2KB
rs1001974069 -- 20,781,581(+) AAGAT(G/T)TTAAA intron-variant
rs1002404188 -- 20,781,227(+) CCCCT(C/T)CCCTA intron-variant, utr-variant-5-prime
rs1002960717 -- 20,782,780(+) GTTTC(C/T)GTTTT intron-variant, downstream-variant-500B
rs1003287689 -- 20,780,396(+) GTGTT(A/G)TGCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE6 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545
esv2759972 CNV gain+loss 17122850
nsv428293 CNV gain+loss 18775914

Variation tolerance for RNASE6 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE6 Gene

Disorders for RNASE6 Gene

Relevant External Links for RNASE6

Genetic Association Database (GAD)
RNASE6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE6

No disorders were found for RNASE6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE6 Gene

Publications for RNASE6 Gene

  1. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PMID: 8836175) Rosenberg H.F. … Dyer K.D. (Nucleic Acids Res. 1996) 2 3 4 22 64
  2. Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PMID: 9647635) Deming M.S. … Rosenberg H.F. (Genome Res. 1998) 2 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation. (PMID: 27089320) Pulido D. … Boix E. (Int J Mol Sci 2016) 3 64
  5. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. (PMID: 25075772) Becknell B. … Spencer J.D. (Kidney Int. 2015) 3 64

Products for RNASE6 Gene

Sources for RNASE6 Gene

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