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Aliases for RNASE6 Gene

Aliases for RNASE6 Gene

  • Ribonuclease, RNase A Family, K6 2 3
  • RNase K6 2 4
  • RNS6 3 4
  • Ribonuclease A D1 3
  • Ribonuclease K6 3
  • EC 63
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • RNasek6 3
  • RAD1 3

External Ids for RNASE6 Gene

Previous HGNC Symbols for RNASE6 Gene

  • RNS6

Previous GeneCards Identifiers for RNASE6 Gene

  • GC14P018621
  • GC14P015036
  • GC14P019239
  • GC14P020319
  • GC14P021249
  • GC14P001370

Summaries for RNASE6 Gene

Entrez Gene Summary for RNASE6 Gene

  • The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]

GeneCards Summary for RNASE6 Gene

RNASE6 (Ribonuclease, RNase A Family, K6) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Chks in Checkpoint Regulation. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE6 Gene

  • May have a role in host defense

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE6 Gene

Genomics for RNASE6 Gene

Regulatory Elements for RNASE6 Gene

Genomic Location for RNASE6 Gene

20,781,051 bp from pter
20,782,467 bp from pter
1,417 bases
Plus strand

Genomic View for RNASE6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE6 Gene

Proteins for RNASE6 Gene

  • Protein details for RNASE6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease K6
    Protein Accession:
    Secondary Accessions:

    Protein attributes for RNASE6 Gene

    150 amino acids
    Molecular mass:
    17196 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE6 Gene

Proteomics data for RNASE6 Gene at MOPED

Post-translational modifications for RNASE6 Gene

  • Glycosylation at Asn55 and Asn100

Other Protein References for RNASE6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for RNASE6 Gene

Gene Families for RNASE6 Gene

  • RNASE :Ribonucleases, RNase A

Protein Domains for RNASE6 Gene

Suggested Antigen Peptide Sequences for RNASE6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q93091
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE6: view

Function for RNASE6 Gene

Molecular function for RNASE6 Gene

GENATLAS Biochemistry:
ribonuclease RNAse A family,k6,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
May have a role in host defense

Enzyme Numbers (IUBMB) for RNASE6 Gene

Gene Ontology (GO) - Molecular Function for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity TAS 8836175
genes like me logo Genes that share ontologies with RNASE6: view

Animal Model Products

miRNA for RNASE6 Gene

miRTarBase miRNAs that target RNASE6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE6

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNASE6 Gene

Localization for RNASE6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE6 Gene


Subcellular locations from

Jensen Localization Image for RNASE6 Gene COMPARTMENTS Subcellular localization image for RNASE6 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 8836175
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE6: view

Pathways for RNASE6 Gene

genes like me logo Genes that share pathways with RNASE6: view

Interacting Proteins for RNASE6 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q93091-RNAS6_HUMAN ENSP00000302046 for RNASE6 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for RNASE6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process TAS 8836175
GO:0006952 defense response TAS 8836175
GO:0090305 nucleic acid phosphodiester bond hydrolysis IBA --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 8836175
genes like me logo Genes that share ontologies with RNASE6: view

Compounds for RNASE6 Gene

(1) Novoseek inferred chemical compound relationships for RNASE6 Gene

Compound -log(P) Hits PubMed IDs
lysine 47 2
genes like me logo Genes that share compounds with RNASE6: view

Transcripts for RNASE6 Gene

mRNA/cDNA for RNASE6 Gene

(89) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE6 Gene

Ribonuclease, RNase A family, k6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE6 Gene

No ASD Table

Relevant External Links for RNASE6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE6 Gene

mRNA expression in normal human tissues for RNASE6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE6 Gene

This gene is overexpressed in Whole Blood (16.0) and Spleen (4.4).

Protein differential expression in normal tissues for RNASE6 Gene

This gene is overexpressed in Kidney (29.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNASE6 Gene

SOURCE GeneReport for Unigene cluster for RNASE6 Gene Hs.23262

mRNA Expression by UniProt/SwissProt for RNASE6 Gene

Tissue specificity: Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletal muscle. Also expressed in monocytes and neutrophils
genes like me logo Genes that share expressions with RNASE6: view

In Situ Assay Products

No data available for Expression partners for RNASE6 Gene

Orthologs for RNASE6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNASE6 35
  • 79.32 (n)
  • 70.8 (a)
  • 68 (a)
(Mus musculus)
Mammalia Rnase6 35
  • 76.23 (n)
  • 65.44 (a)
Rnase6 16
Rnase6 36
  • 64 (a)
(Pan troglodytes)
Mammalia RNASE6 35
  • 99.56 (n)
  • 99.33 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rnase6 35
  • 75.25 (n)
  • 63.97 (a)
(Canis familiaris)
Mammalia RNASE6 36
  • 44 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
(Gallus gallus)
Aves ANG 36
  • 23 (a)
CL2 36
  • 23 (a)
  • 24 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
-- 36
  • 26 (a)
Species with no ortholog for RNASE6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE6 Gene

Gene Tree for RNASE6 (if available)
Gene Tree for RNASE6 (if available)

Paralogs for RNASE6 Gene

Paralogs for RNASE6 Gene

Selected SIMAP similar genes for RNASE6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE6: view

Variants for RNASE6 Gene

Sequence variations from dbSNP and Humsavar for RNASE6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs986192 -- 20,779,061(+) atgaa(A/G)tctaa upstream-variant-2KB
rs986193 -- 20,779,264(+) ttaat(C/T)gctgt upstream-variant-2KB
rs1045917 -- 20,781,918(+) CAGAA(C/T)GTGGC synonymous-codon, reference
rs1045922 - 20,781,965(+) TCGTC(A/G)GCACA missense, reference
rs4981331 -- 20,780,797(+) AAAAA(C/T)TCATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE6 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
dgv607e1 CNV Complex 17122850
nsv428293 CNV Gain+Loss 18775914

Relevant External Links for RNASE6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE6 Gene

Disorders for RNASE6 Gene

Relevant External Links for RNASE6

Genetic Association Database (GAD)

No disorders were found for RNASE6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RNASE6 Gene

Publications for RNASE6 Gene

  1. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PMID: 8836175) Rosenberg H.F. … Dyer K.D. (Nucleic Acids Res. 1996) 2 3 4 23
  2. Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PMID: 9647635) Deming M.S. … Rosenberg H.F. (Genome Res. 1998) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for RNASE6 Gene

Sources for RNASE6 Gene

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