RNASE6 Gene
protein-coding GIFtS: 50
GCID: GC14P021249
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ribonuclease, RNase A family, k6
(Previous symbol: RNS6)
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Aliases
for RNASE6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribonuclease, RNase A Family, K61 2 | | EC 3.1.27.-3 | | RNS61 2 3 | | RNase K63 | | RNasek62 | | EC 3.1.278 | | Ribonuclease K62 | | EC 3.1.27.58 |
Export aliases for RNASE6 gene to outside databasesPrevious GC identifers: GC14P018621 GC14P015036 GC14P019239 GC14P020319 GC14P001370 |
Summaries
for RNASE6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091Function: May have a role in host defense
|
Genomic Views
for RNASE6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNASE6 gene promoter:
PPAR-gamma1 HSF2 Brachyury PPAR-gamma2 LCR-F1 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNASE6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11RNASE6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P021249: view genomic region
(about GC identifiers)
Start:
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21,249,210 bp from pter |
End:
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21,250,626 bp from pter |
Size:
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1,417 bases |
Orientation:
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plus strand |
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Proteins
for RNASE6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091 (See
protein sequence)Recommended Name: Ribonuclease K6 precursor Size: 150 amino acids; 17196 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for RNASE6: NX_Q93091
4/10 DME Specific Peptides for RNASE6 (Q93091) (see all 10)
RNASE6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005606.1
ENSEMBL proteins: ENSP00000302046
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
RNASE6 for ontologies About GeneDecksing
RNASE6 Antibody Products:
Assay Products for RNASE6: |
Protein
Domains /
Families
for RNASE6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNASE6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q93091ProtoNet protein and cluster: Q93091 1 Blocks protein family: IPB001427 Pancreatic ribonuclease
UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091Similarity: Belongs to the pancreatic ribonuclease family |
Function
for RNASE6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091Function: May have a role in host defense Genatlas biochemistry entry for RNASE6:ribonuclease RNAse A family,k6,ubiquitously expressed
Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
RNASE6 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNASE6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE6
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for RNASE6 (Q930912, 3 ENSP000003020464) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
RNASE6 for ontologies About GeneDecksing
|
Drugs & Compounds
for RNASE6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RNASE6 for compounds About GeneDecksing
 Browse Tocris compounds for RNASE6
1 Novoseek chemical compound relationship for RNASE6 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lysine |
47 |
2 |
8836175 (1), 9647635 (1) |
Search CenterWatch for drugs/clinical trials and news about RNASE6 / RNAS6
|
Transcripts
for RNASE6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNASE6 gene: NM_005615.4 Unigene Cluster for RNASE6: Ribonuclease, RNase A family, k6 Hs.23262 [show with all ESTs]Unigene Representative Sequence: BC0208481 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000304677(uc001vye.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE6 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE6
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6 |
Additional cDNA sequence: AK313580.1 BC020848.1 CR456965.1 5 DOTS entries: DT.453979 DT.91803171 DT.92419674 DT.92419675 DT.92419677 24/89 AceView cDNA sequences (see all 89): BM710423 AW406516 AI590889 BP370537 AA456519 BM920166 AA312989 N49002 AI523183 BC020848 AW949723 AW026402 AI080148 NM_005615 AI142565 N71398 BV202530 CD704537 BE466877 BP432143 BG756344 N71348 CD703959 CD695641
GeneLoc Exon Structure
|
Expression
for RNASE6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNASE6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGACTGCA
About this image
See RNASE6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASE6
SOURCE GeneReport for Unigene cluster: Hs.23262
UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091Tissue specificity: Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and skeletalmuscle. Also expressed in monocytes and neutrophils
SABiosciences Custom PCR Arrays for RNASE6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASE6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6 |
Orthologs
for RNASE6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RNASE6 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for RNASE6 (if available)
TreeFam Gene Tree for RNASE6 (if available) |
Paralogs
for RNASE6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNASE6 gene
- RNASE32 RNASE72 RNASE82 ANG2 RNASE42 RNASE12 RNASE22 ENSG000002588182
6 SIMAP similar genes for RNASE6 using alignment to 2 protein entries: RNAS6_HUMAN (see all proteins):RNASE7 RNASE8 RNASE2 RNASE1 RNASE3 RNASE4
RNASE6 for paralogs About GeneDecksing
|
Genomic Variants
for RNASE6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNASE6 (21249210 - 21250626 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RNASE6
2 CNVs: 3930 71865 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE6 |
|
Disorders
/ Diseases
for RNASE6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNASE6 for disorders About GeneDecksing
OMIM gene information: 601981
OMIM disorders: --
1  disease for RNASE6: About MalaCardspancreatitis
Export disorders for RNASE6 gene to outside databases
|
Publications
for RNASE6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNASE6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNASE6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PubMed id 8836175)1, 2, 3, 9 Rosenberg H.F. and Dyer K.D. (1996)
- Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PubMed id 9647635)1, 3, 9 Deming M.S....Rosenberg H.F. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1 Cho S.... Zhang J. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus. (PubMed id 9826755)9 Domachowske J.B....Rosenberg H.F. (1998)
- Eosinophil cationic protein/RNase 3 is another RNase A-family ribonuclease with direct antiviral activity. (PubMed id 9649619)9 Domachowske J.B....Rosenberg H.F. (1998)
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External Searches for RNASE6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RNASE6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNASE6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNASE6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNASE6 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RNASE6 gene:
Search GeneIP for patents involving RNASE6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNASE6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNASE6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE6 | | | OriGene Protein Over-expression Lysate for RNASE6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNASE6 | | OriGene 3'-UTR Clone for RNASE6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASE6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE6 |
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| | | | Search Tocris compounds for RNASE6 |
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 | | | RNASE6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNASE6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6 |
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