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RNASE6 Gene

protein-coding   GIFtS: 53
GCID: GC14P021249

Ribonuclease, RNase A Family, K6


(Previous symbol: RNS6)
  See related diseases
at
MalaCards
 

Aliases
for RNASE6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease, RNase A Family, K61 2     Ribonuclease A D12
RNS61 2 3     Ribonuclease K62
RNase K61 3     EC 3.1.27.-3
RAD12     EC 3.1.278
RNasek62     EC 3.1.27.58

External Ids:    HGNC: 100481   Entrez Gene: 60392   Ensembl: ENSG000001694137   OMIM: 6019815   UniProtKB: Q930913   

Export aliases for RNASE6 gene to outside databases

Previous GC identifers: GC14P018621 GC14P015036 GC14P019239 GC14P020319 GC14P001370


Summaries
for RNASE6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNASE6 Gene:
RNASE6 (ribonuclease, RNase A family, k6) is a protein-coding gene. Diseases associated with RNASE6 include retinitis, and pancreatitis. GO annotations related to this gene include ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091
Function: May have a role in host defense




Genomic Views
for RNASE6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE6 gene promoter:
         PPAR-gamma1   HSF2   Brachyury   PPAR-gamma2   LCR-F1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASE6 promoter sequence
   Search Chromatin IP Primers for RNASE6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11

RNASE6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE6 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021249:  view genomic region     (about GC identifiers)

Start:
 21,249,210 bp from pter      End:
 21,250,626 bp from pter
Size:
 1,417 bases      Orientation:
 plus strand

Proteins
for RNASE6 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091 (See protein sequence)
Recommended Name: Ribonuclease K6 precursor  
Size: 150 amino acids; 17196 Da

Explore the universe of human proteins at neXtProt for RNASE6: NX_Q93091

Explore proteomics data for RNASE6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn55, Asn100
    • Selected DME Specific Peptides for RNASE6 (Q93091) (see all 10)
     YPQCRYS  WFEIQHI  LVPVHLD  SFQNVAA 


    See RNASE6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005606.1  
    ENSEMBL proteins: 
     ENSP00000302046  

    RNASE6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RNASE6
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RNASE6
    GenScript Custom Purified and Recombinant Proteins Services for RNASE6
    Novus Biologicals RNASE6 Protein
    Novus Biologicals RNASE6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNASE6

    RNASE6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNASE6
    Novus Biologicals RNASE6 Antibody
    Abcam antibodies for RNASE6
    Cloud-Clone Corp. Antibodies for RNASE6
    Search ThermoFisher Antibodies for RNASE6
    LSBio Antibodies in human, mouse, rat for RNASE6

    RNASE6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNASE6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNASE6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNASE6
    Cloud-Clone Corp. CLIAs for RNASE6

    Domains /
    Families
    for RNASE6 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry Q93091

    ProtoNet protein and cluster: Q93091

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091
    Similarity: Belongs to the pancreatic ribonuclease family


    RNASE6 for domains           About GeneDecksing


    Function
    for RNASE6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNAS6_HUMAN, Q93091
    Function: May have a role in host defense

         Genatlas biochemistry entry for RNASE6:
    ribonuclease RNAse A family,k6,ubiquitously expressed

         Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004540ribonuclease activity TAS8836175
    GO:0016892endoribonuclease activity, producing 3'-phosphomonoesters IEA--
         
    RNASE6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNASE6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNASE6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASE6

    miRNA
    Products:            		miRTarBase miRNAs that target RNASE6:
    hsa-mir-26b-5p (MIRT030200)

    Block miRNA regulation of human, mouse, rat RNASE6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RNASE6:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmid: RNASE6 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for RNASE6
    Predesigned siRNA for gene silencing in human, mouse, rat RNASE6

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RNASE6

    Clone
    Products:             		 OriGene clones in human, mouse for RNASE6 (see all 7)
    OriGene ORF clones in mouse, rat for RNASE6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RNASE6
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNASE6 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6


    Localization
    for RNASE6 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNAS6_HUMAN, Q93091: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    RNASE6 for ontologies           About GeneDecksing


    Pathways & Interactions
    for RNASE6 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RNASE6
        DNA Repair Mechanisms
    Chks in Checkpoint Regulation
    DNA Damage Induced 14-3-3Sigma Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASE6
    Interactions:

        Search GeneGlobe Interaction Network for RNASE6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RNASE6 (Q930912, 3 ENSP000003020464) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARR3P365752, 3, ENSP000003115384MINT-64402 I2D: score=5 STRING: ENSP00000311538
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process TAS8836175
    GO:0006952defense response TAS8836175
    GO:0090501RNA phosphodiester bond hydrolysis TAS8836175

    RNASE6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNASE6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASE6 (RNAS6)

    1 Novoseek inferred chemical compound relationship for RNASE6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 47 2 8836175 (1), 9647635 (1)



    RNASE6 for compounds           About GeneDecksing



    Transcripts
    for RNASE6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RNASE6 gene: 
    NM_005615.4  

    Unigene Cluster for RNASE6:

    Ribonuclease, RNase A family, k6
    Hs.23262  [show with all ESTs]
    Unigene Representative Sequence: BC020848
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304677(uc001vye.4)
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat RNASE6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate RNASE6:
    hsa-miR-137
    SwitchGear 3'UTR luciferase reporter plasmid: RNASE6 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for RNASE6
    Predesigned siRNA for gene silencing in human, mouse, rat RNASE6
    Clone
    Products:             		 OriGene clones in human, mouse for RNASE6 (see all 7)
    OriGene ORF clones in mouse, rat for RNASE6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE6 (NM_005615)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE6
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for RNASE6
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE6
      QuantiTect SYBR Green Assays in human, mouse, rat RNASE6
      QuantiFast Probe-based Assays in human, mouse, rat RNASE6

    Additional mRNA sequence: 

    AK313580.1 BC020848.1 CR456965.1 

    5 DOTS entries:

    DT.453979  DT.91803171  DT.92419674  DT.92419675  DT.92419677 

    Selected AceView cDNA sequences (see all 89):

    BM710423 BP370537 AW406516 AA312989 BM920166 AI590889 AA456519 BE466696 
    AW949723 N71348 AA973893 N71398 AW026402 BG756344 BC020848 N49002 
    AW104264 BE466877 CD702355 BM671863 AI142565 CD695641 NM_005615 CD688056 

    GeneLoc Exon Structure


    Expression
    for RNASE6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASE6 expression in normal human tissues (normalized intensities)      RNASE6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGACTGCA
    RNASE6 Expression
    About this image


    RNASE6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    RNASE6 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    RNASE6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23262

    UniProtKB/Swiss-Prot: RNAS6_HUMAN, Q93091
    Tissue specificity: Strong expression in lung, followed by heart, placenta, kidney, pancreas, liver, brain and
    skeletal muscle. Also expressed in monocytes and neutrophils

        Custom PCR Arrays for RNASE6
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RNASE6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE6
    QuantiTect SYBR Green Assays in human, mouse, rat RNASE6
    QuantiFast Probe-based Assays in human, mouse, rat RNASE6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE6

    Orthologs
    for RNASE6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE6 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnase61 , 5 ribonuclease, RNase A family, 61, 5 76.23(n)1
    65.44(a)1    		   14 (26.39 cM)5
    784161  NM_030098.21  NP_084374.21 
     511290685 
    chicken
    (Gallus gallus)    		 Aves RSFR6
    CL26
    (see all 3)    		 Gallus gallus liver ribonuclease A (CL2), mRNA.
    (see all 3)    		 24(a)
    23(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 6(8804970-8806179)
    4(49041665-49042706)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 Uncharacterized protein
    		 26(a)
    23(a)
    		 many ↔ many
    many ↔ many
    		 GL343220.1(1531632-1532063)
    GL343220.1(1279015-1279452)


    ENSEMBL Gene Tree for RNASE6 (if available)
    TreeFam Gene Tree for RNASE6 (if available)

    Paralogs
    for RNASE6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for RNASE6 gene
    RNASE32  RNASE82  RNASE72  RNASE22  RNASE12  ANG2  RNASE42  
    5 SIMAP similar genes for RNASE6 using alignment to 2 protein entries:     RNAS6_HUMAN (see all proteins):
    RNASE7    RNASE8    RNASE2    RNASE1    RNASE3

    RNASE6 for paralogs           About GeneDecksing



    Genomic Variants
    for RNASE6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNASE6 (see all 120)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs9861921,2
    		C,F,A,H--21247220(+) atgaaG/Atctaa 1 -- us2k120Minor allele frequency- A:0.36NS EA NA WA CSA 1743
    rs791578581,2
    		C,F--21247294(+) TAACTT/ATTCTC 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs128823031,2
    		C,F--21247394(+) tgtctA/Gttttt 1 -- us2k16Minor allele frequency- G:0.23NA WA EA 364
    rs1890160241,2
    		--21247395(+) GTCTAC/TTTTTC 1 -- us2k10--------
    rs1494441671,2
    		--21247412(+) AACACA/CCTGTC 1 -- us2k10--------
    rs1446682121,2
    		C--21247414(+) CACACA/TGTCTT 1 -- us2k10--------
    rs9861931,2
    		C,F--21247423(+) ttaatT/Cgctgt 1 -- us2k1 tfbs38Minor allele frequency- C:0.38WA NA CSA EA 367
    rs128866881,2
    		C,F--21247475(+) tgactT/Ctgttc 1 -- us2k16Minor allele frequency- C:0.24NA WA EA 364
    rs1383325631,2
    		--21247499(+) TTGTGA/TTGACT 1 -- us2k10--------
    rs285481381,2
    		C,F--21247508(+) CTATTC/GTGAAT 1 -- us2k12Minor allele frequency- G:0.29NA EA 240

    HapMap Linkage Disequilibrium report for RNASE6 (21249210 - 21250626 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNASE6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428293CNV Gain+Loss18775914
    esv23438CNV Gain+Loss19812545
    dgv607e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASE6
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE6

    Disorders / Diseases
    for RNASE6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus    		 OMIM gene information: 601981    OMIM disorders: --

    2 diseases for RNASE6:    About MalaCards
    retinitis    pancreatitis


    RNASE6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RNASE6

    Export disorders for RNASE6 gene to outside databases

    Publications
    for RNASE6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNASE6 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with RNASE6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human ribonuclease (RNase k6): increasing diversity in the enlarging ribonuclease gene family. (PubMed id 8836175)1, 2, 3, 9 Rosenberg H.F. and Dyer K.D. (Nucleic Acids Res. 1996)
    2. Ribonuclease k6: chromosomal mapping and divergent rates of evolution within the RNase A gene superfamily. (PubMed id 9647635)1, 3, 9 Deming M.S....Rosenberg H.F. (Genome Res. 1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Comparative genomic analysis of eutherian ribonuclease A genes. (PubMed id 24337645)1 Premzl M. (Mol. Genet. Genomics 2014)
    5. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    8. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1 Cho S.... Zhang J. (Genomics 2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Evolution of antiviral activity in the ribonuclease A gene superfamily: evidence for a specific interaction between eosinophil-derived neurotoxin (EDN/RNase 2) and respiratory syncytial virus. (PubMed id 9826755)9 Domachowske J.B....Rosenberg H.F. (Nucleic Acids Res. 1998)

    External Searches for RNASE6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing RNASE6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6039 HGNC: 10048 AceView: RNASE6 Ensembl:ENSG00000169413 euGenes: HUgn6039
    ECgene: RNASE6 H-InvDB: RNASE6

    Other Databases showing RNASE6 gene

    (According to HUGE)
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    Specialized Databases showing RNASE6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNASE6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNASE6 gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    TryGeneCards Plus    		Patent Information for RNASE6 gene:
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