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RNASE4 Gene

protein-coding   GIFtS: 48
GCID: GC14P021191

Ribonuclease, RNase A Family, 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease, RNase A Family, 41 2     Ribonuclease 42
RNS42 3 5     Ribonuclease A B12
RNase 42 3     EC 3.1.27.-3
RAB12     EC 3.1.278

External Ids:    HGNC: 100471   Entrez Gene: 60382   Ensembl: ENSG000002588187   OMIM: 6010305   UniProtKB: P340963   

Export aliases for RNASE4 gene to outside databases

Previous GC identifers: GC14P018523 GC14P014939 GC14P019142 GC14P020222 GC14P021153 GC14P001274 GC14P021155 GC14P021157 GC14P021166 GC14P021170 GC14P021176 GC14P021185


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNASE4 Gene:
The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA
cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in
four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share
promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
(provided by RefSeq, Aug 2013)

GeneCards Summary for RNASE4 Gene:
RNASE4 (ribonuclease, RNase A family, 4) is a protein-coding gene. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096
Function: This RNase has marked specificity towards the 3' side of uridine nucleotides

Gene Wiki entry for RNASE4 (Ribonuclease 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE4 gene promoter:
         COUP-TF1   AP-1   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   COUP-TF   deltaCREB   STAT3   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RNASE4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11

RNASE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021191:  view genomic region     (about GC identifiers)

Start:
21,152,259 bp from pter      End:
21,168,761 bp from pter
Size:
16,503 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096 (See protein sequence)
Recommended Name: Ribonuclease 4 precursor  
Size: 147 amino acids; 16840 Da
2 PDB 3D structures from and Proteopedia for RNASE4:
1RNF (3D)        2RNF (3D)    

Explore the universe of human proteins at neXtProt for RNASE4: NX_P34096

Explore proteomics data for RNASE4 at MOPED

4 DME Specific Peptides for RNASE4 (P34096)
 ICSTTNI  MYQRFLRQHV  CKRFNTFIHED  STRRVVIACEG 


See RNASE4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts): 
NP_001269121.1  NP_001269122.1  NP_002928.1  NP_919412.1  

ENSEMBL proteins: 
 ENSP00000452245   ENSP00000381081   ENSP00000451624   ENSP00000307096  

RNASE4 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for RNASE4
OriGene Custom MassSpec
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Novus Biologicals RNASE4 Protein
Novus Biologicals RNASE4 Lysates
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Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for RNASE4

 
Search eBioscience for Proteins for RNASE4 

 
antibodies-online proteins for RNASE4 (12 products) 

 
Search antibodies-online for peptides for RNASE4

RNASE4 Antibody Products:

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antibodies-online antibodies for RNASE4 (17 products) 

RNASE4 Assay Products:

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Cloud-Clone Corp. ELISAs for RNASE4
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antibodies-online kits for RNASE4 (10 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RNASE: Ribonucleases, RNase A

3 InterPro protein domains:
 IPR023411 RNaseA_AS
 IPR023412 RNaseA_domain
 IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry P34096

ProtoNet protein and cluster: P34096

1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096
Similarity: Belongs to the pancreatic ribonuclease family


Find genes that share domains with RNASE4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RNAS4_HUMAN, P34096
Function: This RNase has marked specificity towards the 3' side of uridine nucleotides

     Genatlas biochemistry entry for RNASE4:
ribonuclease,RNAse A family,4,expressed in a number of human somatic tissues but not brain,with two alternatively
spliced isoforms

     Enzyme Numbers (IUBMB): EC 3.1.272 EC 3.1.27.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0004522pancreatic ribonuclease activity NAS7742370
     
Find genes that share ontologies with RNASE4           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for RNASE4

miRNA
Products:
    
miRTarBase miRNAs that target RNASE4:
hsa-mir-215-5p (MIRT024338), hsa-mir-192-5p (MIRT026275), hsa-mir-335-5p (MIRT017156)

Block miRNA regulation of human, mouse, rat RNASE4 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate RNASE4:
hsa-miR-203 hsa-miR-545 hsa-miR-105
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RNASE4
Predesigned siRNA for gene silencing in human, mouse, rat RNASE4

Gene Editing
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DNA2.0 Custom Protein Engineering Service for RNASE4

Clone
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OriGene clones in human, mouse for RNASE4 (see all 14)
OriGene ORF clones in mouse, rat for RNASE4
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GenScript: all cDNA clones in your preferred vector (see all 2): RNASE4 (NM_002937)
Sino Biological Human cDNA Clone for RNASE4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE4

Cell Line
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GenScript Custom overexpressing Cell Line Services for RNASE4
Browse ESI BIO Cell Lines and PureStem Progenitors for RNASE4 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RNAS4_HUMAN, P34096: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IDA3467790

Find genes that share ontologies with RNASE4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASE4
Interactions:

    Search GeneGlobe Interaction Network for RNASE4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RNASE4 (ENSP000003070964) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TDGF1ENSP000002961454STRING: ENSP00000296145
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006379mRNA cleavage NAS7742370
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic NAS7742370

Find genes that share ontologies with RNASE4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RNASE4 (RNAS4)

2 DrugBank Compounds for RNASE4    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Citric Acid-- 77-92-9target----
Pyroglutamic Acid-- 98-79-3target----

1 Novoseek inferred chemical compound relationship for RNASE4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
uridine 65.3 2 9878400 (2)



Find genes that share compounds with RNASE4           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RNASE4 gene (5 alternative transcripts): 
NM_001282192.1  NM_001282193.1  NM_002937.4  NM_194431.2  NM_194430.1  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000555835(uc001vxy.4 uc001vxx.4) ENST00000397995 ENST00000555597
ENST00000304704
miRNA
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Block miRNA regulation of human, mouse, rat RNASE4 using miScript Target Protectors
3 qRT-PCR Assays for microRNAs that regulate RNASE4:
hsa-miR-203 hsa-miR-545 hsa-miR-105
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RNASE4
Predesigned siRNA for gene silencing in human, mouse, rat RNASE4
Clone
Products:
     
OriGene clones in human, mouse for RNASE4 (see all 14)
OriGene ORF clones in mouse, rat for RNASE4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RNASE4 (NM_002937)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RNASE4
OriGene qSTAR qPCR primer pairs in human, mouse for RNASE4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE4
  QuantiTect SYBR Green Assays in human, mouse, rat RNASE4
  QuantiFast Probe-based Assays in human, mouse, rat RNASE4

Selected AceView cDNA sequences (see all 333):

BM995510 AA317789 AA027188 BG564488 BG569248 AI168617 AW338069 BM980362 
CB161736 AI934356 AA999895 T29333 BX248010 BQ013922 AV646929 AA953339 
NM_194430 BG563237 BX444128 BF509059 BU682731 AA418935 BM054905 BX247985 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNASE4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RNASE4 Expression
About this image


RNASE4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 9) fully expand
 
 Kidney (Urinary System)    fully expand to see all 2 entries
         Renal Collecting Duct System
 
 Liver (Hepatobiliary System)
         Perivenous Hepatocytes Liver Lobule
 
 Gut Tube (Gastrointestinal Tract)
         Midgut
 
 Inner Cell Mass (Early Embryonic Tissues)
         Blimp1- mVenus and stella-ECFP genetically modified stem cells
 
 Lower Urinary Tract (Urinary System)
         Ureter
RNASE4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RNASE4 Protein Expression
    Custom PCR Arrays for RNASE4
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OriGene qPCR primer pairs and template standards for RNASE4
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QuantiFast Probe-based Assays in human, mouse, rat RNASE4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for RNASE4 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnase41 , 5 ribonuclease, RNase A family 41, 5 84.47(n)1
84.25(a)1
  14 (26.37 cM)5
588091  NM_021472.41  NP_067447.21 
 510910775 
chicken
(Gallus gallus)
Aves RSFR6
ANG6
(see all 3)
Gallus gallus leukocyte ribonuclease A-2 (RSFR), m...
Gallus gallus angiogenin, ribonuclease, RNase A fa...
(see all 3)
35(a)
33(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
6(8804970-8806179)
6(8796401-8797835)
lizard
(Anolis carolinensis)
Reptilia --
--
Uncharacterized protein
41(a)
34(a)
many ↔ many
many ↔ many
GL343220.1(1531632-1532063)
GL343220.1(1279015-1279452)


ENSEMBL Gene Tree for RNASE4 (if available)
TreeFam Gene Tree for RNASE4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RNASE4 gene
RNASE32  RNASE82  RNASE72  RNASE22  RNASE12  ANG2  RNASE62  
3 SIMAP similar genes for RNASE4 using alignment to 2 protein entries:     RNAS4_HUMAN (see all proteins):
RAB1    RNASE1    ANG

Find genes that share paralogs with RNASE4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RNASE4 (see all 442)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1807513851,2
--2149017(+) TAAATC/TTGATT 1 -- us2k10--------
rs1866602821,2
--2149038(+) GAAATA/GTGGCC 1 -- us2k10--------
rs65713401,2
C,F,A,H--2149174(+) TTAGGA/GACCCG 1 -- us2k113Minor allele frequency- G:0.44NA WA CSA EA 377
rs726599721,2
C--2149396(+) CTCTTC/TCCCCC 1 -- us2k10--------
rs581328201,2
C,F--2149475(+) ACTGCT/CCCATT 1 -- us2k14Minor allele frequency- C:0.28WA CSA EA 242
rs1409873551,2
--2149537(+) TTGGGA/GGGGAA 1 -- us2k10--------
rs1170549311,2
C,F--2149595(+) CCGCCC/GTCTCC 1 -- us2k11Minor allele frequency- G:0.02EA 120
rs341219421,2
C,F--2149740(+) CCAGTG/AAGGCC 1 -- us2k110Minor allele frequency- A:0.10NA EA WA 608
rs1894918661,2
--2149873(+) AACCTC/TGGACG 1 -- us2k10--------
rs1151804421,2
F--2149915(+) CTGCAG/ATAATT 1 -- us2k11Minor allele frequency- A:0.01WA 118

HapMap Linkage Disequilibrium report for RNASE4 (21152259 - 21168761 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for RNASE4:    About this table    
Variant IDTypeSubtypePubMed ID
nsv1203CNV Loss18451855
esv23438CNV Gain+Loss19812545

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RNASE4
DNA2.0 Custom Variant and Variant Library Synthesis for RNASE4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 601030    OMIM disorders: --


Find genes that share disorders with RNASE4           About GenesLikeMe

Genetic Association Database (GAD): RNASE4
Human Genome Epidemiology (HuGE) Navigator: RNASE4 (15 documents)

Export disorders for RNASE4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RNASE4 gene, integrated from 10 sources (see all 24):
(articles sorted by number of sources associating them with RNASE4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. (PubMed id 7501448)1, 2, 3, 9 Rosenberg H.F. and Dyer K.D. (Nucleic Acids Res. 1995)
  2. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. (PubMed id 9878400)1, 2, 9 Terzyan S.S.... Coll M. (J. Mol. Biol. 1999)
  3. The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. (PubMed id 8223579)1, 2, 9 Zhou H.-M. and Strydom D.J. (Eur. J. Biochem. 1993)
  4. Use of genome-wide expression data to mine the &quot;Gray Zone&quot; of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (PLoS Genet. 2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Molecular cloning and expression of human ribonuclease 4 cDNA. (PubMed id 7742370)1, 2 Seno M....Yamada H. (Biochim. Biophys. Acta 1995)
  7. Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity. (PubMed id 3467790)1, 2 Shapiro R.... Vallee B.L. (Biochemistry 1986)
  8. Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro. (PubMed id 9366257)1, 9 Egesten A....Rosenberg H.F. (Biochim. Biophys. Acta 1997)
  9. Comparative genomic analysis of eutherian ribonuclease A genes. (PubMed id 24337645)1 Premzl M. (Mol. Genet. Genomics 2014)
  10. Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress. (PubMed id 23143660)1 Li S....Hu G.F. (Angiogenesis 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6038 HGNC: 10047 AceView: ANG Ensembl:ENSG00000258818 euGenes: HUgn6038
ECgene: RNASE4 H-InvDB: RNASE4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RNASE4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RNASE4 gene:
Search GeneIP for patents involving RNASE4

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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