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Aliases for RNASE4 Gene

Aliases for RNASE4 Gene

  • Ribonuclease A Family Member 4 2 3
  • Ribonuclease, RNase A Family, 4 2 3 5
  • RNase 4 3 4
  • RNS4 3 4
  • Ribonuclease A B1 3
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • RAB1 3

External Ids for RNASE4 Gene

Previous GeneCards Identifiers for RNASE4 Gene

  • GC14P018523
  • GC14P014939
  • GC14P019142
  • GC14P020222
  • GC14P021153
  • GC14P001274
  • GC14P021155
  • GC14P021157
  • GC14P021166
  • GC14P021170
  • GC14P021176
  • GC14P021185
  • GC14P021191
  • GC14P020688
  • GC14P020696

Summaries for RNASE4 Gene

Entrez Gene Summary for RNASE4 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]

GeneCards Summary for RNASE4 Gene

RNASE4 (Ribonuclease A Family Member 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE4 Gene

  • This RNase has marked specificity towards the 3 side of uridine nucleotides.

Gene Wiki entry for RNASE4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE4 Gene

Genomics for RNASE4 Gene

Regulatory Elements for RNASE4 Gene

Enhancers for RNASE4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RNASE4 on UCSC Golden Path with GeneCards custom track

Promoters for RNASE4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNASE4 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE4 Gene

20,684,100 bp from pter
20,701,215 bp from pter
17,116 bases
Plus strand

Genomic View for RNASE4 Gene

Genes around RNASE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE4 Gene

Proteins for RNASE4 Gene

  • Protein details for RNASE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease 4
    Protein Accession:

    Protein attributes for RNASE4 Gene

    147 amino acids
    Molecular mass:
    16840 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE4 Gene

neXtProt entry for RNASE4 Gene

Proteomics data for RNASE4 Gene at MOPED

Selected DME Specific Peptides for RNASE4 Gene

Post-translational modifications for RNASE4 Gene

No Post-translational modifications

Other Protein References for RNASE4 Gene

Domains & Families for RNASE4 Gene

Gene Families for RNASE4 Gene

Protein Domains for RNASE4 Gene

Suggested Antigen Peptide Sequences for RNASE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE4: view

Function for RNASE4 Gene

Molecular function for RNASE4 Gene

GENATLAS Biochemistry:
ribonuclease,RNAse A family,4,expressed in a number of human somatic tissues but not brain,with two alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
This RNase has marked specificity towards the 3 side of uridine nucleotides.

Enzyme Numbers (IUBMB) for RNASE4 Gene

Gene Ontology (GO) - Molecular Function for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004540 ribonuclease activity IBA --
genes like me logo Genes that share ontologies with RNASE4: view
genes like me logo Genes that share phenotypes with RNASE4: view

Animal Model Products

miRNA for RNASE4 Gene

miRTarBase miRNAs that target RNASE4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE4 Gene

Localization for RNASE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE4 Gene


Subcellular locations from

Jensen Localization Image for RNASE4 Gene COMPARTMENTS Subcellular localization image for RNASE4 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for RNASE4 Gene

Pathways & Interactions for RNASE4 Gene

SuperPathways for RNASE4 Gene

No Data Available

Interacting Proteins for RNASE4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000381081 for RNASE4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RNASE4 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNASE4 Gene

Drugs & Compounds for RNASE4 Gene

(2) Drugs for RNASE4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Deoxyuridine 3'-Monophosphate Experimental Pharma Target 0
genes like me logo Genes that share compounds with RNASE4: view

Transcripts for RNASE4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE4 Gene

No ASD Table

Relevant External Links for RNASE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE4 Gene

mRNA expression in normal human tissues for RNASE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNASE4 Gene

This gene is overexpressed in Serum (17.7), Plasma (14.6), Saliva (10.2), and Milk (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE4 Gene

genes like me logo Genes that share expression patterns with RNASE4: view

Protein tissue co-expression partners for RNASE4 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNASE4 Gene

Orthologs for RNASE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RNASE4 35
  • 89.5 (n)
  • 88.36 (a)
  • 88 (a)
(Canis familiaris)
Mammalia RNASE4 35
  • 83.87 (n)
  • 84.68 (a)
  • 83 (a)
(Mus musculus)
Mammalia Rnase4 35
  • 84.47 (n)
  • 84.25 (a)
Rnase4 16
Rnase4 36
  • 83 (a)
(Pan troglodytes)
Mammalia RNASE4 35
  • 99.77 (n)
  • 99.32 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Rnase4 35
  • 81.05 (n)
  • 82.88 (a)
(Monodelphis domestica)
Mammalia RNASE4 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia RNASE4 36
  • 69 (a)
(Gallus gallus)
Aves ANG 36
  • 33 (a)
CL2 36
  • 29 (a)
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
-- 36
  • 41 (a)
Species with no ortholog for RNASE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE4 Gene

Gene Tree for RNASE4 (if available)
Gene Tree for RNASE4 (if available)

Paralogs for RNASE4 Gene

Paralogs for RNASE4 Gene

(3) SIMAP similar genes for RNASE4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE4: view

Variants for RNASE4 Gene

Sequence variations from dbSNP and Humsavar for RNASE4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3748338 - 20,699,417(+) TGCTG(A/G/T)CCCTG reference, missense
rs2873964 -- 20,697,966(+) CTCCA(A/G)TCTTG intron-variant
rs8005306 -- 20,696,551(+) AGAAA(A/C)ATTTT intron-variant
rs1888560 -- 20,696,086(+) ATCAT(C/T)GCTGC intron-variant
rs1888561 -- 20,696,349(+) TTCTA(C/T)CACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE4 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
nsv1203 CNV Loss 18451855

Variation tolerance for RNASE4 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RNASE4 Gene

Disorders for RNASE4 Gene

Relevant External Links for RNASE4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNASE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE4 Gene

Publications for RNASE4 Gene

  1. Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. (PMID: 7501448) Rosenberg H.F. … Dyer K.D. (Nucleic Acids Res. 1995) 2 3 4 23 67
  2. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. (PMID: 9878400) Terzyan S.S. … Coll M. (J. Mol. Biol. 1999) 3 23
  3. Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro. (PMID: 9366257) Egesten A. … Rosenberg H.F. (Biochim. Biophys. Acta 1997) 3 23
  4. The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. (PMID: 8223579) Zhou H.-M. … Strydom D.J. (Eur. J. Biochem. 1993) 3 23
  5. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3

Products for RNASE4 Gene

Sources for RNASE4 Gene