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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE4 Gene

protein-coding   GIFtS: 47
GCID: GC14P021185

Ribonuclease, RNase A Family, 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, 41 2
RNS42 3 5
RNase 42 3
Ribonuclease 42
EC 3.1.27.-3
EC 3.1.278

External Ids:    HGNC: 100471   Entrez Gene: 60382   Ensembl: ENSG000002588187   OMIM: 6010305   UniProtKB: P340963   

Export aliases for RNASE4 gene to outside databases

Previous GC identifers: GC14P018523 GC14P014939 GC14P019142 GC14P020222 GC14P021153 GC14P001274 GC14P021155 GC14P021157 GC14P021166 GC14P021170 GC14P021176


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNASE4 Gene:
The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA
cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in
four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share
promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
(provided by RefSeq, Aug 2013)

GeneCards Summary for RNASE4 Gene: 
RNASE4 (ribonuclease, RNase A family, 4) is a protein-coding gene. Diseases associated with RNASE4 include pancreatitis, and hypoxia. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096
Function: This RNase has marked specificity towards the 3' side of uridine nucleotides

Gene Wiki entry for RNASE4 (Ribonuclease 4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE4 gene promoter:
         COUP-TF1   AP-1   COUP   HNF-4alpha2   Nkx2-5   HNF-4alpha1   COUP-TF   deltaCREB   STAT3   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RNASE4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11

RNASE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021185:  view genomic region     (about GC identifiers)

Start:
21,152,259 bp from pter      End:
21,168,761 bp from pter
Size:
16,503 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096 (See protein sequence)
Recommended Name: Ribonuclease 4 precursor  
Size: 147 amino acids; 16840 Da
Subcellular location: Secreted
2 PDB 3D structures from and Proteopedia for RNASE4:
1RNF (3D)        2RNF (3D)    

Explore the universe of human proteins at neXtProt for RNASE4: NX_P34096

Explore proteomics data for RNASE4 at MOPED 

4 DME Specific Peptides for RNASE4 (P34096)
 ICSTTNI  MYQRFLRQHV  CKRFNTFIHED  STRRVVIACEG 

RNASE4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RNASE4 Protein Expression
REFSEQ proteins (4 alternative transcripts): 
NP_001269121.1  NP_001269122.1  NP_002928.1  NP_919412.1  

ENSEMBL proteins: 
 ENSP00000452245   ENSP00000381081   ENSP00000451624   ENSP00000307096  

Human Recombinant Protein Products for RNASE4: 
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OriGene Protein Over-expression Lysate for RNASE4
OriGene Custom MassSpec 
OriGene Custom Protein Services for RNASE4
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Novus Biologicals RNASE4 Protein
Novus Biologicals RNASE4 Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for RNASE4 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IDA3467790

RNASE4 for ontologies           About GeneDecksing



RNASE4 Antibody Products: 
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Cloud-Clone Corp. CLIAs for RNASE4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNASE: Ribonucleases, RNase A

3 InterPro protein domains:
 IPR023411 RNaseA_AS
 IPR023412 RNaseA_domain
 IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry P34096

ProtoNet protein and cluster: P34096

1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096
Similarity: Belongs to the pancreatic ribonuclease family


RNASE4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RNAS4_HUMAN, P34096
Function: This RNase has marked specificity towards the 3' side of uridine nucleotides

     Genatlas biochemistry entry for RNASE4:
ribonuclease,RNAse A family,4,expressed in a number of human somatic tissues but not brain,with two alternatively
spliced isoforms

     Enzyme Numbers (IUBMB): EC 3.1.272 EC 3.1.27.-1

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0004522pancreatic ribonuclease activity NAS7742370
     
RNASE4 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE4 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE4 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASE4 

miRNA
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Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of RNASE4

Clone
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OriGene clones in human, mouse for RNASE4 (see all 17)
OriGene ORF clones in mouse, rat for RNASE4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): RNASE4 (NM_002937)
Sino Biological Human cDNA Clone for RNASE4
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE4
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                     Customized lentivirus expression plasmids for stable overexpression of RNASE4 

Cell Line
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Search LifeMap BioReagents cell lines for RNASE4
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE4


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RNASE4 (ENSP000003070964) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TDGF1ENSP000002961454STRING: ENSP00000296145
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006379mRNA cleavage NAS7742370

RNASE4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RNASE4 for compounds           About GeneDecksing

EMD Millipore small molecules for RNASE4:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNASE4 (RNAS4)

2 DrugBank Compounds for RNASE4    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Citric Acid-- 77-92-9target----
Pyroglutamic Acid-- 98-79-3target----

1 Novoseek inferred chemical compound relationship for RNASE4 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
uridine 65.3 2 9878400 (2)

Search CenterWatch for drugs/clinical trials and news about RNASE4 / RNAS4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNASE4 gene (5 alternative transcripts): 
NM_001282192.1  NM_001282193.1  NM_002937.4  NM_194431.2  NM_194430.1  

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000555835(uc001vxy.4 uc001vxx.4) ENST00000397995 ENST00000555597
ENST00000304704
miRNA
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hsa-miR-203 hsa-miR-545 hsa-miR-105
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
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Clone
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OriGene ORF clones in mouse, rat for RNASE4
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GenScript: all cDNA clones in your preferred vector (see all 2): RNASE4 (NM_002937)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE4
Sirion Biotech Customized lentivirus for stable overexpression of RNASE4 
                     Customized lentivirus expression plasmids for stable overexpression of RNASE4 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RNASE4
OriGene qSTAR qPCR primer pairs in human, mouse for RNASE4
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE4
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE4

24/333 AceView cDNA sequences (see all 333):

BM054905 BM825329 BQ013922 BI822577 NM_002937 BG567799 BI906326 AV647739 
AA418935 AI978618 CB046059 AA635528 AW338069 BU620311 BU552571 BX247985 
BM995510 N54486 R28749 BG563237 BF509059 CB164343 AV647754 AV646929 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASE4 expression in normal human tissues (normalized intensities)      RNASE4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RNASE4 Expression
About this image


RNASE4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/16 selected tissues (see all 16) fully expand
 
 Kidney (Urinary System)    fully expand to see all 3 entries
         Renal Collecting Duct System
         visceral organ/metanephros/calyx   
 
 Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
         Ureter
         visceral organ/metanephros/calyx   
 
 Fibroblast
         Human Conjunctival Fibroblasts (HConF)   
 
 Liver (Hepatobiliary System)
         Perivenous Hepatocytes Liver Lobule
 
 Gut Tube (Gastrointestinal Tract)
         Midgut

See RNASE4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASE4
    SABiosciences Custom PCR Arrays for RNASE4
Primer
Products:
OriGene qPCR primer pairs and template standards for RNASE4
OriGene qSTAR qPCR primer pairs in human, mouse for RNASE4
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RNASE4 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnase41 , 5 ribonuclease, RNase A family 41, 5 84.47(n)1
84.25(a)1
  14 (26.37 cM)5
588091  NM_021472.41  NP_067447.21 
 510910775 
chicken
(Gallus gallus)
Aves RSFR6
ANG6
(see all 3)
Angiogenin
(see all 3)
33(a)
32(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
6(8804970-8806179)
6(8796401-8797835)
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 3)
Uncharacterized protein
(see all 3)
42(a)
32(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
GL343220.1(1531632-1532063)
GL343220.1(1279015-1279452)


ENSEMBL Gene Tree for RNASE4 (if available)
TreeFam Gene Tree for RNASE4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RNASE4 gene
RNASE32  RNASE82  RNASE72  RNASE22  RNASE12  ANG2  RNASE62  
2 SIMAP similar genes for RNASE4 using alignment to 1 protein entry:     RNAS4_HUMAN:
RNASE1    ANG

RNASE4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/442 SNPs in RNASE4 are shown (see all 442)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1807513851,2
--2149017(+) TAAATC/TTGATT 1 -- us2k10--------
rs1866602821,2
--2149038(+) GAAATA/GTGGCC 1 -- us2k10--------
rs65713401,2
C,F,A,H--2149174(+) TTAGGA/GACCCG 1 -- us2k113Minor allele frequency- G:0.44NA WA CSA EA 377
rs726599721,2
C--2149396(+) CTCTTC/TCCCCC 1 -- us2k10--------
rs581328201,2
C,F--2149475(+) ACTGCT/CCCATT 1 -- us2k14Minor allele frequency- C:0.28WA CSA EA 242
rs1409873551,2
--2149537(+) TTGGGA/GGGGAA 1 -- us2k10--------
rs1170549311,2
C,F--2149595(+) CCGCCC/GTCTCC 1 -- us2k11Minor allele frequency- G:0.02EA 120
rs341219421,2
C,F--2149740(+) CCAGTG/AAGGCC 1 -- us2k110Minor allele frequency- A:0.10NA EA WA 608
rs1894918661,2
--2149873(+) AACCTC/TGGACG 1 -- us2k10--------
rs1151804421,2
F--2149915(+) CTGCAG/ATAATT 1 -- us2k11Minor allele frequency- A:0.01WA 118

HapMap Linkage Disequilibrium report for RNASE4 (21152259 - 21168761 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for RNASE4:    About this table     
Variant IDTypeSubtypePubMed ID
nsv1203CNV Loss18451855
esv23438CNV Gain+Loss19812545

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing RNASE4
DNA2.0 Custom Variant and Variant Library Synthesis for RNASE4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 601030    OMIM disorders: --

4 diseases for RNASE4:    About MalaCards
pancreatitis    hypoxia    obesity    hepatocellular carcinoma


RNASE4 for disorders           About GeneDecksing

Genetic Association Database (GAD): RNASE4
Human Genome Epidemiology (HuGE) Navigator: RNASE4 (15 documents)

Export disorders for RNASE4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RNASE4 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with RNASE4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. (PubMed id 7501448)1, 2, 3, 9 Rosenberg H.F. and Dyer K.D. (1995)
  2. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. (PubMed id 9878400)1, 2, 9 Terzyan S.S.... Coll M. (1999)
  3. The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. (PubMed id 8223579)1, 2, 9 Zhou H.-M. and Strydom D.J. (1993)
  4. Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1, 4 Naukkarinen J....Peltonen L. (2010)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Molecular cloning and expression of human ribonuclease 4 cDNA. (PubMed id 7742370)1, 2 Seno M....Yamada H. (1995)
  7. Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity. (PubMed id 3467790)1, 2 Shapiro R.... Vallee B.L. (1986)
  8. Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro. (PubMed id 9366257)1, 9 Egesten A....Rosenberg H.F. (1997)
  9. Ribonuclease 4 protects neuron degeneration by promoti ng angiogenesis, neurogenesis, and neuronal survival under stress. (PubMed id 23143660)1 Li S....Hu G.F. (2013)
  10. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 6038 HGNC: 10047 AceView: ANG Ensembl:ENSG00000258818 euGenes: HUgn6038
ECgene: RNASE4 H-InvDB: RNASE4

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RNASE4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RNASE4 gene:
Search GeneIP for patents involving RNASE4

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 EMD Millipore small molecules (inhibitor) for RNASE4
 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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 Regulatory tfbs in RNASE4 promoter
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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