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Aliases for RNASE4 Gene

Aliases for RNASE4 Gene

  • Ribonuclease, RNase A Family, 4 2 3
  • RNase 4 3 4
  • RNS4 3 4
  • Ribonuclease A B1 3
  • EC 3.1.27.- 4
  • EC 3.1.27 63
  • RAB1 3

External Ids for RNASE4 Gene

Previous GeneCards Identifiers for RNASE4 Gene

  • GC14P018523
  • GC14P014939
  • GC14P019142
  • GC14P020222
  • GC14P021153
  • GC14P001274
  • GC14P021155
  • GC14P021157
  • GC14P021166
  • GC14P021170
  • GC14P021176
  • GC14P021185
  • GC14P021191
  • GC14P020688

Summaries for RNASE4 Gene

Entrez Gene Summary for RNASE4 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]

GeneCards Summary for RNASE4 Gene

RNASE4 (Ribonuclease, RNase A Family, 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE4 Gene

  • This RNase has marked specificity towards the 3 side of uridine nucleotides

Gene Wiki entry for RNASE4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE4 Gene

Genomics for RNASE4 Gene

Regulatory Elements for RNASE4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RNASE4 Gene

Chromosome:
14
Start:
20,684,100 bp from pter
End:
20,701,215 bp from pter
Size:
17,116 bases
Orientation:
Plus strand

Genomic View for RNASE4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE4 Gene

Proteins for RNASE4 Gene

  • Protein details for RNASE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34096-RNAS4_HUMAN
    Recommended name:
    Ribonuclease 4
    Protein Accession:
    P34096

    Protein attributes for RNASE4 Gene

    Size:
    147 amino acids
    Molecular mass:
    16840 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE4 Gene

neXtProt entry for RNASE4 Gene

Proteomics data for RNASE4 Gene at MOPED

Selected DME Specific Peptides for RNASE4 Gene

Post-translational modifications for RNASE4 Gene

No Post-translational modifications

Other Protein References for RNASE4 Gene

Domains & Families for RNASE4 Gene

Gene Families for RNASE4 Gene

Protein Domains for RNASE4 Gene

Suggested Antigen Peptide Sequences for RNASE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P34096

UniProtKB/Swiss-Prot:

RNAS4_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE4: view

Function for RNASE4 Gene

Molecular function for RNASE4 Gene

GENATLAS Biochemistry:
ribonuclease,RNAse A family,4,expressed in a number of human somatic tissues but not brain,with two alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
This RNase has marked specificity towards the 3 side of uridine nucleotides

Enzyme Numbers (IUBMB) for RNASE4 Gene

Gene Ontology (GO) - Molecular Function for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004522 ribonuclease A activity NAS 7742370
GO:0004540 ribonuclease activity IBA --
genes like me logo Genes that share ontologies with RNASE4: view

Phenotypes for RNASE4 Gene

genes like me logo Genes that share phenotypes with RNASE4: view

Animal Model Products

miRNA for RNASE4 Gene

miRTarBase miRNAs that target RNASE4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE4

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE4 Gene

Localization for RNASE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE4 Gene COMPARTMENTS Subcellular localization image for RNASE4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 3467790
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE4: view

Pathways & Interactions for RNASE4 Gene

SuperPathways for RNASE4 Gene

No Data Available

Interacting Proteins for RNASE4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381081%0d%0a9606.ENSP00000344193%0d%0a
Selected Interacting proteins: ENSP00000381081 for RNASE4 Gene via STRING

Symbol External ID(s) Details
RNASE1

Gene Ontology (GO) - Biological Process for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006379 mRNA cleavage NAS 7742370
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic NAS 7742370
genes like me logo Genes that share ontologies with RNASE4: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE4 Gene

Drugs & Compounds for RNASE4 Gene

(2) Drugs for RNASE4 Gene - From: DrugBank and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Deoxyuridine 3'-Monophosphate Experimental Pharma Target 0
Uridine Experimental Pharma 0
genes like me logo Genes that share compounds with RNASE4: view

Transcripts for RNASE4 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE4 Gene

No ASD Table

Relevant External Links for RNASE4 Gene

GeneLoc Exon Structure for
RNASE4
ECgene alternative splicing isoforms for
RNASE4

Expression for RNASE4 Gene

mRNA expression in normal human tissues for RNASE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNASE4 Gene

This gene is overexpressed in Serum (17.7), Plasma (14.6), Saliva (10.2), and Milk (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE4 Gene



genes like me logo Genes that share expression patterns with RNASE4: view

Protein tissue co-expression partners for RNASE4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNASE4 Gene

Orthologs for RNASE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASE4 35
  • 89.5 (n)
  • 88.36 (a)
RNASE4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNASE4 35
  • 83.87 (n)
  • 84.68 (a)
RNASE4 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnase4 35
  • 84.47 (n)
  • 84.25 (a)
Rnase4 16
Rnase4 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNASE4 35
  • 99.77 (n)
  • 99.32 (a)
RNASE4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnase4 35
  • 81.05 (n)
  • 82.88 (a)
oppossum
(Monodelphis domestica)
Mammalia RNASE4 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNASE4 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANG 36
  • 33 (a)
ManyToMany
CL2 36
  • 29 (a)
ManyToMany
RSFR 36
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for RNASE4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE4 Gene

ENSEMBL:
Gene Tree for RNASE4 (if available)
TreeFam:
Gene Tree for RNASE4 (if available)

Paralogs for RNASE4 Gene

Paralogs for RNASE4 Gene

(3) SIMAP similar genes for RNASE4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE4: view

Variants for RNASE4 Gene

Sequence variations from dbSNP and Humsavar for RNASE4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3094 -- 20,699,896(+) AGCTG(C/T)CCCAG utr-variant-3-prime
rs944438 -- 20,696,468(+) GGAAA(A/G)AGAAG intron-variant
rs1888560 -- 20,696,086(+) ATCAT(C/T)GCTGC intron-variant
rs1888561 -- 20,696,349(+) TTCTA(C/T)CACAA intron-variant
rs1888562 -- 20,696,377(+) TAAAA(C/T)GTCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE4 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
nsv1203 CNV Loss 18451855

Variation tolerance for RNASE4 Gene

Residual Variation Intolerance Score: 73.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE4 Gene

HapMap Linkage Disequilibrium report
RNASE4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE4 Gene

Disorders for RNASE4 Gene

Relevant External Links for RNASE4

Genetic Association Database (GAD)
RNASE4
Human Genome Epidemiology (HuGE) Navigator
RNASE4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE4
genes like me logo Genes that share disorders with RNASE4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE4 Gene

Publications for RNASE4 Gene

  1. Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. (PMID: 7501448) Rosenberg H.F. … Dyer K.D. (Nucleic Acids Res. 1995) 2 23 67
  2. Angiogenin cleaves tRNA and promotes stress-induced translational repression. (PMID: 19332886) Yamasaki S. … Anderson P. (J. Cell Biol. 2009) 23 67
  3. Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer. (PMID: 16052224) Ord J.J. … Harris A.L. (Br. J. Cancer 2005) 23 67
  4. Toward rational design of ribonuclease inhibitors: high-resolution crystal structure of a ribonuclease A complex with a potent 3',5'-pyrophosphate-linked dinucleotide inhibitor. (PMID: 10441122) Leonidas D.D. … Acharya K.R. (Biochemistry 1999) 23 67
  5. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. (PMID: 9878400) Terzyan S.S. … Coll M. (J. Mol. Biol. 1999) 23 67

Products for RNASE4 Gene

Sources for RNASE4 Gene

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