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Aliases for RNASE4 Gene

Aliases for RNASE4 Gene

  • Ribonuclease A Family Member 4 2 3 5
  • Ribonuclease, RNase A Family, 4 2 3
  • RNase 4 3 4
  • RNS4 3 4
  • Ribonuclease A B1 3
  • Ribonuclease 4 3
  • EC 3.1.27.- 4
  • EC 3.1.27 58
  • RAB1 3

External Ids for RNASE4 Gene

Previous GeneCards Identifiers for RNASE4 Gene

  • GC14P018523
  • GC14P014939
  • GC14P019142
  • GC14P020222
  • GC14P021153
  • GC14P001274
  • GC14P021155
  • GC14P021157
  • GC14P021166
  • GC14P021170
  • GC14P021176
  • GC14P021185
  • GC14P021191
  • GC14P020688
  • GC14P020696
  • GC14P020704
  • GC14P020714
  • GC14P020724
  • GC14P020736

Summaries for RNASE4 Gene

Entrez Gene Summary for RNASE4 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]

GeneCards Summary for RNASE4 Gene

RNASE4 (Ribonuclease A Family Member 4) is a Protein Coding gene. Diseases associated with RNASE4 include Amyotrophic Lateral Sclerosis 1. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE1.

UniProtKB/Swiss-Prot for RNASE4 Gene

  • This RNase has marked specificity towards the 3 side of uridine nucleotides.

Gene Wiki entry for RNASE4 Gene

Additional gene information for RNASE4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE4 Gene

Genomics for RNASE4 Gene

Regulatory Elements for RNASE4 Gene

Enhancers for RNASE4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H020679 1.9 FANTOM5 ENCODE dbSUPER 20 +0.4 433 9.8 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A SSRP1 ZNF610 METTL3 ENSG00000258515 SUPT16H CHD8 PARP2 TTC5 PIP4P1 METTL17 RNASE4 ENSG00000258768
GH14H020691 1.2 Ensembl ENCODE 9.7 +7.2 7201 0.6 ELF3 TBP TBL1XR1 ARID4B SIN3A ZNF2 RAD21 RFX5 YY1 SCRT2 SUPT16H METTL3 METTL17 RNASE4 ENSG00000259171 ENSG00000258451
GH14H020662 1.3 Ensembl ENCODE 6.6 -20.4 -20400 1.8 ARID4B SIN3A ZNF2 ZNF143 ZNF207 SP3 REST ZNF592 KAT8 SSRP1 SUPT16H PARP2 METTL3 CHD8 TTC5 ENSG00000258515 METTL17 PIP4P1 ENSG00000258768 ENSG00000260830
GH14H020697 1 Ensembl ENCODE 7.6 +13.8 13768 0.5 CTCF TAL1 RAD21 RFX5 TCF12 CC2D1A GATA3 GATA2 NCOR1 POLR2A RNASE4 ENSG00000258451 ENSG00000259171
GH14H020692 0.4 dbSUPER 8.1 +8.3 8347 0.4 NRF1 RNASE4 ENSG00000259171 ENSG00000258451
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASE4 on UCSC Golden Path with GeneCards custom track

Promoters for RNASE4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066391 -800 4201 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1

Genomic Locations for RNASE4 Gene

Genomic Locations for RNASE4 Gene
17,116 bases
Plus strand

Genomic View for RNASE4 Gene

Genes around RNASE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE4 Gene

Proteins for RNASE4 Gene

  • Protein details for RNASE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease 4
    Protein Accession:

    Protein attributes for RNASE4 Gene

    147 amino acids
    Molecular mass:
    16840 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE4 Gene

neXtProt entry for RNASE4 Gene

Selected DME Specific Peptides for RNASE4 Gene


Post-translational modifications for RNASE4 Gene

No Post-translational modifications

Other Protein References for RNASE4 Gene

Domains & Families for RNASE4 Gene

Gene Families for RNASE4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for RNASE4 Gene

Suggested Antigen Peptide Sequences for RNASE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE4: view

Function for RNASE4 Gene

Molecular function for RNASE4 Gene

GENATLAS Biochemistry:
ribonuclease,RNAse A family,4,expressed in a number of human somatic tissues but not brain,with two alternatively spliced isoforms
UniProtKB/Swiss-Prot Function:
This RNase has marked specificity towards the 3 side of uridine nucleotides.

Enzyme Numbers (IUBMB) for RNASE4 Gene

Phenotypes From GWAS Catalog for RNASE4 Gene

Gene Ontology (GO) - Molecular Function for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004522 ribonuclease A activity NAS 7742370
GO:0004540 ribonuclease activity IBA --
genes like me logo Genes that share ontologies with RNASE4: view
genes like me logo Genes that share phenotypes with RNASE4: view

Animal Model Products

miRNA for RNASE4 Gene

miRTarBase miRNAs that target RNASE4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE4 Gene

Localization for RNASE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,IEA 3467790
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE4 Gene

Pathways & Interactions for RNASE4 Gene

SuperPathways for RNASE4 Gene

No Data Available

Interacting Proteins for RNASE4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: P34096-RNAS4_HUMAN ENSP00000381081 for RNASE4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006379 mRNA cleavage NAS 7742370
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASE4: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE4 Gene

Drugs & Compounds for RNASE4 Gene

(2) Drugs for RNASE4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Deoxyuridine 3'-Monophosphate Experimental Pharma Target 0
genes like me logo Genes that share compounds with RNASE4: view

Transcripts for RNASE4 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE4 Gene

No ASD Table

Relevant External Links for RNASE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNASE4 Gene

This gene is overexpressed in Serum (17.7), Plasma (14.6), Saliva (10.2), and Milk (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE4 Gene

Protein tissue co-expression partners for RNASE4 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE4 Gene:


Evidence on tissue expression from TISSUES for RNASE4 Gene

  • Bone marrow(4)
  • Pancreas(4)
  • Liver(3.3)
genes like me logo Genes that share expression patterns with RNASE4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE4 Gene

Orthologs for RNASE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE4 34 33
  • 99.77 (n)
(Bos Taurus)
Mammalia RNASE4 34 33
  • 89.5 (n)
(Mus musculus)
Mammalia Rnase4 34 16 33
  • 84.47 (n)
(Canis familiaris)
Mammalia RNASE4 34 33
  • 83.87 (n)
(Rattus norvegicus)
Mammalia Rnase4 33
  • 81.05 (n)
(Ornithorhynchus anatinus)
Mammalia RNASE4 34
  • 69 (a)
(Monodelphis domestica)
Mammalia RNASE4 34
  • 66 (a)
(Gallus gallus)
Aves RSFR 34
  • 35 (a)
ANG 34
  • 33 (a)
CL2 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
-- 34
  • 34 (a)
Species where no ortholog for RNASE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE4 Gene

Gene Tree for RNASE4 (if available)
Gene Tree for RNASE4 (if available)

Paralogs for RNASE4 Gene

Paralogs for RNASE4 Gene

(3) SIMAP similar genes for RNASE4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE4: view

Variants for RNASE4 Gene

Sequence variations from dbSNP and Humsavar for RNASE4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs121909535 Pathogenic 20,693,671(+) GACCC(A/T)GCACT intron-variant, reference, missense
rs121909536 Pathogenic 20,693,686(+) TGCCA(A/T)ACCAC intron-variant, reference, missense
rs121909537 Pathogenic 20,693,685(+) ATGCC(A/G)AACCA intron-variant, reference, missense
rs121909538 Pathogenic 20,693,728(+) CATGA(A/G)GAGAC intron-variant, reference, missense
rs121909539 Pathogenic 20,693,753(+) CCCTG(C/G)AAAGA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RNASE4 Gene

Variant ID Type Subtype PubMed ID
nsv1203 CNV deletion 18451855
esv3633688 CNV loss 21293372
esv3633687 CNV loss 21293372
esv23438 CNV gain+loss 19812545

Variation tolerance for RNASE4 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE4 Gene

Disorders for RNASE4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNASE4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RNASE4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RNASE4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE4 Gene

Publications for RNASE4 Gene

  1. Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. (PMID: 7501448) Rosenberg HF … Dyer KD (Nucleic acids research 1995) 2 3 4 22 60
  2. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. (PMID: 9878400) Terzyan SS … Coll M (Journal of molecular biology 1999) 3 4 22 60
  3. The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. (PMID: 8223579) Zhou HM … Strydom DJ (European journal of biochemistry 1993) 3 4 22 60
  4. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for RNASE4 Gene

Sources for RNASE4 Gene

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