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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RNASE4 Gene

protein-coding GIFtS: 49
GCID: GC14P021176

ribonuclease, RNase A family, 4

Explore 6 diseases affiliated with
RNASE4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, 4¹ ²
RNS4² ³ ⁵
RNase 4² ³
Ribonuclease 4²
EC 3.1.27.-³
EC 3.1.27⁸

External Ids:	HGNC: 10047¹	Entrez Gene: 6038²	Ensembl: ENSG00000181784⁷	OMIM: 601030⁵	UniProtKB: P34096³

Export aliases for RNASE4 gene to outside databases

Previous GC identifers: GC14P018523 GC14P014939 GC14P019142 GC14P020222 GC14P021153 GC14P001274 GC14P021155 GC14P021157 GC14P021166 GC14P021170

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RNASE4:

The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA

cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in two

transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5'

exons. Each gene splices to a unique downstream exon that contains its complete coding region. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096

Function: This RNase has marked specificity towards the 3' side of uridine nucleotides

Gene Wiki entry for RNASE4 (Ribonuclease 4)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RNASE4 gene promoter:
COUP-TF1 AP-1 COUP HNF-4alpha2 Nkx2-5 HNF-4alpha1 COUP-TF deltaCREB STAT3 RSRFC4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for RNASE4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11

RNASE4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE4 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P021176: view genomic region (about GC identifiers)

Start:	21,152,372 bp from pter	End:	21,168,758 bp from pter
Size:	16,387 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096 (See protein sequence)

Recommended Name: Ribonuclease 4 precursor

Size: 147 amino acids; 16840 Da

Subcellular location: Secreted

2 PDB 3D structures from and Proteopedia for RNASE4:

1RNF (3D)

2RNF (3D)

Explore the universe of human proteins at neXtProt for RNASE4: NX_P34096

4 DME Specific Peptides for RNASE4 (P34096)

ICSTTNI

MYQRFLRQHV

CKRFNTFIHED

STRRVVIACEG

RNASE4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002928.1 NP_919412.1

ENSEMBL proteins:

ENSP00000381087 ENSP00000307096 ENSP00000381085

Human Recombinant Protein Products:

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 4): RNASE4 OriGene Custom Protein Services for RNASE4
	GenScript Custom Purified and Recombinant Proteins Services for RNASE4
	Novus Biologicals RNASE4 Protein Novus Biologicals RNASE4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RNASE4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IDA	3467790

RNASE4 for ontologies About GeneDecksing

RNASE4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
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	GenScript Custom Superior Antibodies Services for RNASE4
	Search for Antibodies for RNASE4 at Abcam
	Uscn Antibodies for RNASE4
	Search ThermoFisher Antibodies for RNASE4

Assay Products for RNASE4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RNASE4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RNASE4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RNASE4 for domains About GeneDecksing

3 InterPro domains/families:

IPR023411 RNaseA_AS

IPR023412 RNaseA_domain

IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry P34096

ProtoNet protein and cluster: P34096

1 Blocks protein family: IPB001427 Pancreatic ribonuclease

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096

Similarity: Belongs to the pancreatic ribonuclease family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RNAS4_HUMAN, P34096

Function: This RNase has marked specificity towards the 3' side of uridine nucleotides

Genatlas biochemistry entry for RNASE4:

ribonuclease,RNAse A family,4,expressed in a number of human somatic tissues but not brain,with two alternatively

spliced isoforms

Enzyme Numbers (IUBMB): EC 3.1.27² EC 3.1.27.-¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RNASE4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE4
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RNASE4:
		hsa-miR-203 hsa-miR-545 hsa-miR-105
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE4 (see all 7) OriGene shRNA RFP: RNASE4 OriGene siRNA: RNASE4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RNASE4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RNASE4 (NM_002937)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RNASE4
		Search LifeMap BioReagents cell lines for RNASE4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE4

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0004522	pancreatic ribonuclease activity	NAS	7742370

RNASE4 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for RNASE4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for RNASE4 (ENSP00000307096⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TDGF1	ENSP00000296145⁴	STRING: ENSP00000296145

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006379	mRNA cleavage	NAS	7742370

RNASE4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RNASE4 for compounds About GeneDecksing

EMD Millipore small molecules for RNASE4:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNASE4

2 DrugBank Compounds for RNASE4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Citric Acid	--	77-92-9	target	--	--
Pyroglutamic Acid	--	98-79-3	target	--	--

1 Novoseek chemical compound relationship for RNASE4 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
uridine	65.3	2	9878400 (2)

Search CenterWatch for drugs/clinical trials and news about RNASE4 / RNAS4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNASE4 gene (3 alternative transcripts):

NM_002937.3 NM_194431.1 NM_194430.1

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000398001 ENST00000304704 ENST00000397999(uc001vya.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RNASE4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE4
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate RNASE4:
		hsa-miR-203 hsa-miR-545 hsa-miR-105
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE4 (see all 7) OriGene shRNA RFP: RNASE4 OriGene siRNA: RNASE4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE4 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RNASE4 (NM_002937)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RNASE4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE4

24/333 AceView cDNA sequences (see all 333):

BM800182 AI934356 AA862345 CA447209 NM_194430 CB154272 CK904582 BM785359

CB215920 R28749 BI759778 NM_194431 AI168617 BE856015 BQ009590 BG564488

AA027188 CB157060 BU620311 CF528880 BU552571 AA418935 BU732659 AA424174

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RNASE4 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	·	4d
SP1:									-		-				-		-		-
SP2:									-		-		-		-		-		-
SP3:									-		-
SP4:							-		-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for RNASE4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASE4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RNASE4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Heart

Primitive Heart Tube

Primitive Heart Tube Cells

Myocardium

Gut Tube

Lower Urinary Tract

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See RNASE4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RNASE4

SABiosciences Custom PCR Arrays for RNASE4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RNASE4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RNASE4 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RSFR_CHICK⁶ RNL2_CHICK⁶	Ribonuclease CL2	34(a) 31(a)	many ↔ many many ↔ many	6(10376970-10386988) 4(51109366-51110407)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	40(a) 32(a) (see all 3)	many ↔ many many ↔ many (see all 3)	GL343220.1(1531632-1532063) GL343220.1(1279015-1279452)
zebrafish (Danio rerio)	Actinopterygii	rnasel3⁶ rnasel2⁶	ribonuclease like 2	27(a) 27(a)	many ↔ many many ↔ many	14(40044381-40046544) 22(6217650-6218836)

ENSEMBL Gene Tree for RNASE4 (if available)
TreeFam Gene Tree for RNASE4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RNASE4 gene

RNASE3² RNASE7² RNASE8² ANG² RNASE6² RNASE1² RNASE2² ENSG00000258818²

4 SIMAP similar genes for RNASE4 using alignment to 1 protein entry: RNAS4_HUMAN:

RNASE1 ANG RNASE7 RNASE6

RNASE4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78160595^1,2	F,	--	21162874(+)	`GGCTCG/ATAGCT`	2	--	int¹		1		WA	118
rs58909887^1,2	C	--	21163043(+)	`ACACA-/CATATAC`	2	--	int¹		0	--	--	--	--
rs187162901^1,2		--	21163164(+)	`TCATGC/GTTATT`	2	--	int¹		0	--	--	--	--
rs191663589^1,2		--	21163228(+)	`ATCAAC/TTAATG`	2	--	int¹		0	--	--	--	--
rs184685870^1,2		--	21163264(+)	`AGTTAG/TAGAAG`	2	--	int¹		0	--	--	--	--
rs143622835^1,2		--	21163274(+)	`GATTCC/TGGCCA`	2	--	int¹		0	--	--	--	--
rs12893068^1,2		--	21163447(+)	`TACTCA/GGGAGG`	2	--	int¹		1		NA	2
rs190017766^1,2		--	21163486(+)	`GAGGCA/GGAGGT`	2	--	int¹		0	--	--	--	--
rs140827896^1,2		--	21163502(+)	`TGAGCC/TGAGAT`	2	--	int¹		0	--	--	--	--
rs144616272^1,2		--	21163510(+)	`GATCAC/TGCCAC`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RNASE4 (21152372 - 21168758 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for RNASE4
8 CNVs: 87129 87128 76572 76571 87130 76570 87131 71865

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE4

DNA2.0 Custom Variant and Variant Library Synthesis for RNASE4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RNASE4 for disorders           About GeneDecksing

OMIM gene information: 601030    OMIM disorders: --

6 diseases for RNASE4:    About MalaCards

pancreatitis colon carcinoma hepatocellular carcinoma obesity

carcinoma hypoxia

Human Genome Epidemiology (HuGE) Navigator: RNASE4 (15 documents)

Export disorders for RNASE4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNASE4 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with RNASE4)

Utopia: connect your pdf to the dynamic
world of online information

Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. (PubMed id 7501448)^{1, 2, 3, 9} Rosenberg H.F. and Dyer K.D. (1995)
The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. (PubMed id 9878400)^{1, 2, 9} Terzyan S.S.... Coll M. (1999)
The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. (PubMed id 8223579)^{1, 2, 9} Zhou H.-M. and Strydom D.J. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular cloning and expression of human ribonuclease 4 cDNA. (PubMed id 7742370)^{1, 2} Seno M....Yamada H. (1995)
Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity. (PubMed id 3467790)^{1, 2} Shapiro R.... Vallee B.L. (1986)
Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro. (PubMed id 9366257)^{1, 9} Egesten A....Rosenberg H.F. (1997)
Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)¹ Naukkarinen J....Peltonen L. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6038	HGNC: 10047	AceView: ANG	Ensembl:ENSG00000181784	euGenes: HUgn6038
ECgene: RNASE4	H-InvDB: RNASE4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNASE4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNASE4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RNASE4 gene:
Search GeneIP for patents involving RNASE4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	Browse OriGene Antibodies		OriGene shRNA RFP for RNASE4
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	OriGene Protein Over-expression Lysate for RNASE4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RNASE4		OriGene 3'-UTR Clone for RNASE4
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASE4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE4
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE4
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	GenScript Custom Purified and Recombinant Proteins Services for RNASE4		GenScript cDNA clones with any tag delivered in your preferred vector for RNASE4
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	GenScript Custom overexpressing Cell Line Services for RNASE4		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE4

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RNASE4 gene at Home site.

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RNASE4 Gene

ribonuclease, RNase A family, 4

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RNASE4 Gene

ribonuclease, RNase A family, 4

Aliasesfor RNASE4 gene

Summariesfor RNASE4 gene

Genomic Viewsfor RNASE4 gene

Proteinsfor RNASE4 gene

Protein Domains /Familiesfor RNASE4 gene

Functionfor RNASE4 gene

Pathways & Interactionsfor RNASE4 gene

Drugs & Compoundsfor RNASE4 gene

Transcriptsfor RNASE4 gene

Expression for RNASE4 gene

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Disorders / Diseasesfor RNASE4 gene

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Genome Databases showing RNASE4 gene

Other Databases showing RNASE4 gene

Specialized Databases showing RNASE4 gene

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Aliases
for RNASE4 gene

Summaries
for RNASE4 gene

Genomic Views
for RNASE4 gene

Proteins
for RNASE4 gene

Protein Domains /
Families
for RNASE4 gene

Function
for RNASE4 gene

Pathways & Interactions
for RNASE4 gene

Drugs & Compounds
for RNASE4 gene

Transcripts
for RNASE4 gene

Expression
for RNASE4 gene

Orthologs
for RNASE4 gene

Paralogs
for RNASE4 gene

Genomic Variants
for RNASE4 gene

Disorders / Diseases
for RNASE4 gene

Publications
for RNASE4 gene

Intellectual Property
for RNASE4 gene

Products
for RNASE4 gene