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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE3 Gene

protein-coding   GIFtS: 55
GCID: GC14P021359

ribonuclease, RNase A family, 3


(Previous symbol: RNS3)
 Explore 128 diseases affiliated with
RNASE3 via our new
 Human Malady Compendium 
Biological research products
for RNASE3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, 31 2     Cytotoxic Ribonuclease2
ECP1 2 3 5     Eosinophil Cationic Protein2
RNS31 2 3 5     EC 3.1.27.-3
Ribonuclease 32 3     EC 3.1.278
RNase 32 3     EC 3.1.27.58

External Ids:    HGNC: 100461   Entrez Gene: 60372   Ensembl: ENSG000001693977   OMIM: 1313985   UniProtKB: P127243   

Export aliases for RNASE3 gene to outside databases

Previous GC identifers: GC14P018731 GC14P015146 GC14P019349 GC14P020429 GC14P001480


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ECP_HUMAN, P12724
Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of
biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of
preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of
the overall cell shape and partial loss of cell content

Gene Wiki entry for RNASE3 (Eosinophil cationic protein)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE3 gene promoter:
         AML1a   Lmo2   NF-kappaB   C/EBPalpha   Evi-1   CHOP-10   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASE3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24-q31   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q24-q31

RNASE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021359:  view genomic region     (about GC identifiers)

Start:
21,359,558 bp from pter      End:
21,360,507 bp from pter
Size:
950 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ECP_HUMAN, P12724 (See protein sequence)
Recommended Name: Eosinophil cationic protein precursor  
Size: 160 amino acids; 18385 Da
Subunit: Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and
insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends
to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7
Subcellular location: Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released
following activation by an immune stimulus
6 PDB 3D structures from and Proteopedia for RNASE3:
1DYT (3D)        1H1H (3D)        1QMT (3D)        2KB5 (3D)        4A2O (3D)        4A2Y (3D)    
Secondary accessions: Q4VBC1 Q8WTP7 Q8WZ62 Q9GZN9

Explore the universe of human proteins at neXtProt for RNASE3: NX_P12724

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12724

  • 4/6 DME Specific Peptides for RNASE3 (P12724) (see all 6)
     VACDNRD  VVNVCGN  YPVVPVHLD  RCKNQNTFL 

    RNASE3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002926.2  
    ENSEMBL proteins: 
     ENSP00000302324  

    Human Recombinant Protein Products: 
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    Novus Biologicals RNASE3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RNASE3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005625soluble fraction ----


    RNASE3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RNASE3


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RNASE3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P12724

    ProtoNet protein and cluster: P12724

    1 Blocks protein family: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: ECP_HUMAN, P12724
    Similarity: Belongs to the pancreatic ribonuclease family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ECP_HUMAN, P12724
    Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of
    biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of
    preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of
    the overall cell shape and partial loss of cell content

         Genatlas biochemistry entry for RNASE3:
    ribonuclease RNAse A family,3,eosinophil cationic protein

    Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE3 (see all 4)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE3

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    Clone
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RNASE3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0004540ribonuclease activity TAS2745977


    RNASE3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Allograft rejection
    Asthma0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for RNASE3):
        Asthma


    RNASE3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNASE3

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process TAS2745977
    GO:0042742defense response to bacterium IEA--


    RNASE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNASE3 for compounds           About GeneDecksing

    EMD Millipore small molecules for RNASE3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASE3

    3 DrugBank Compounds for RNASE3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pranlukast-- 103177-37-3targetother/unknown10028377 15136379 11476469 10804983
    Adenosine-2'-5'-Diphosphate-- --target--17139284 17016423
    Citric Acid-- 77-92-9target--17139284 17016423

    10/112 Novoseek chemical compound relationships for RNASE3 gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methacholine 82.1 95 12549774 (2), 8874658 (2), 7982122 (2), 17537187 (2) (see all 62)
    histamine 77.9 252 8622322 (5), 8568122 (4), 10453855 (4), 9390492 (4) (see all 99)
    unicap 77.9 10 15934281 (1), 16124647 (1), 17040428 (1), 17205697 (1) (see all 9)
    budesonide 69.8 37 12452208 (3), 8335852 (3), 1430701 (2), 10384060 (2) (see all 19)
    montelukast 68.6 26 20112601 (4), 11842294 (4), 12736396 (3), 10588996 (2) (see all 14)
    fluticasone propionate 68 29 9690571 (3), 11167349 (2), 12823118 (2), 17446966 (1) (see all 17)
    allergens 67 37 9591438 (2), 9893184 (2), 8603280 (1), 10536888 (1) (see all 24)
    pranlukast 65.7 17 11796443 (3), 11476469 (2), 10028377 (1), 10848924 (1) (see all 7)
    lte4 63 32 17339866 (4), 10542994 (3), 11393122 (2), 11551254 (2) (see all 9)
    ltc4 60.3 38 8130655 (4), 16450573 (3), 9821474 (2), 8790750 (2) (see all 17)

    Search CenterWatch for drugs/clinical trials and news about RNASE3 / ECP 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNASE3 gene: 
    NM_002935.2  

    Unigene Cluster for RNASE3:

    Ribonuclease, RNase A family, 3
    Hs.73839  [show with all ESTs]
    Unigene Representative Sequence: DN998783
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304639(uc001vyj.3)

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    SwitchGear 3'UTR luciferase reporter plasmidRNASE3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE3 (see all 4)
    OriGene shRNA RFP: RNASE3
    OriGene siRNA: RNASE3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE3
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE3
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    Additional cDNA sequence: 

    BC096060.1 BC096061.3 BC096062.3 M28128.1 X15161.1 

    1 DOTS entry:

    DT.408898 

    12 AceView cDNA sequences:

    NM_002935 BX280390 BI028557 BM714612 X15161 AA587166 AJ705510 M28128 
    BF895434 BI030233 BF902198 AW075940 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RNASE3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNASE3

    SOURCE GeneReport for Unigene cluster: Hs.73839
        SABiosciences Expression via Pathway-Focused PCR Array including RNASE3: 
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RNASE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE3 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RSFR_CHICK6
    RNL2_CHICK6
    Ribonuclease CL2
    22(a)
    21(a)
    many ↔ many
    many ↔ many
    6(10376970-10386988)
    4(51109366-51110407)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    --
    25(a)
    23(a)
    (see all 3)
    possible ortholog
    many ↔ many
    (see all 3)
    GL343220.1(1438299-1438661)
    GL343220.1(1279015-1279452)
    zebrafish
    (Danio rerio)
    Actinopterygii rnasel26
    rnasel36
    ribonuclease like 3
    22(a)
    22(a)
    many ↔ many
    many ↔ many
    22(6217650-6218836)
    14(40044381-40046544)


    ENSEMBL Gene Tree for RNASE3 (if available)
    TreeFam Gene Tree for RNASE3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNASE3 gene
    RNASE72  RNASE82  ANG2  RNASE62  RNASE42  RNASE12  RNASE22  ENSG000002588182  
    5 SIMAP similar genes for RNASE3 using alignment to 1 protein entry:     ECP_HUMAN:
    RNASE2    ECRP    RNASE7    RNASE6    RNASE8

    RNASE3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/100 NCBI SNPs in RNASE3 are shown (see all 100    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172930181,2
    F,--21357609(+) GTCTTC/TAGGAG 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs1150413911,2
    F,--21357641(+) ACAGAT/CAGGAT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1501025551,2
    --21357665(+) GAGAGC/TGGAGT 1 -- us2k10--------
    rs1140808031,2
    F,--21357668(+) AGTGGA/GGTCAG 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs767647401,2
    F,--21357669(+) GTGGAG/ATCAGA 1 -- us2k11Minor allele frequency- A:0.12EA 120
    rs1170199621,2
    F,--21357686(+) CCCTGA/CGCTAG 1 -- us2k11Minor allele frequency- C:0.12EA 120
    rs755593511,2
    F,--21357707(+) ACAGAC/TGCAGC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs619803621,2
    C,--21357708(+) CAGACG/ACAGCT 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1166524471,2
    F,--21357744(+) ACCAAT/CGGTGC 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs285325331,2
    C,--21357845(+) AACATC/TATAAA 1 -- us2k13Minor allele frequency- T:0.20NA WA 122

    HapMap Linkage Disequilibrium report for RNASE3 (21359558 - 21360507 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for RNASE3
         10 CNVs: 87132 76575 66587 35236 30650 38870 31955 3037 3930 9726
    Human Gene Mutation Database (HGMD): RNASE3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE3
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RNASE3 for disorders           About GeneDecksing

    OMIM gene information: 131398    OMIM disorders: --

    20/128 diseases for RNASE3 (see all 128):    About MalaCards
    prurigo nodularis    hyper-ige syndrome    churg-strauss syndrome    otitis media
    cough variant asthma    common cold    ocular cicatricial pemphigoid    cicatricial pemphigoid
    herpes gestationis    lfflers endocarditis    intrinsic asthma    eosinophilic pneumonia
    helminthiasis    status asthmaticus    chronic maxillary sinusitis    anisakiasis
    toxocariasis    collagenous colitis    elephantiasis    rhinitis

    13 diseases from the University of Copenhagen DISEASES database for RNASE3:
    Asthma     Allergic rhinitis     Eosinophilia     Hypersensitivity reaction type I disease
    Atopic dermatitis     Keratoconjunctivitis     Loeffler endocarditis     Common cold
    Bronchiolitis     Churg-Strauss syndrome     Conjunctivitis     Bronchitis
    Urticaria

    10/97 Novoseek disease relationships for RNASE3 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 88.7 778 8717287 (8), 8857106 (7), 7894629 (6), 2053855 (5) (see all 99)
    allergic rhinitis 84.3 78 19760211 (4), 12889102 (4), 8203234 (3), 11019593 (2) (see all 44)
    inflammation 82.8 283 10520059 (5), 10353094 (4), 10520078 (3), 7547335 (3) (see all 99)
    eosinophilia 82.4 83 16340277 (4), 14533663 (3), 9130522 (2), 8744107 (2) (see all 54)
    rhinitis 81.2 78 9578915 (4), 10522945 (3), 11468003 (3), 16521419 (3) (see all 38)
    rhinitis allergic seasonal 81.1 32 10857776 (3), 15934281 (2), 10232439 (2), 7499684 (1) (see all 20)
    asthma allergic 79.3 19 8648010 (2), 1373987 (2), 8947065 (1), 9578914 (1) (see all 16)
    dermatitis atopic 75.4 114 9558841 (5), 10520078 (4), 7894629 (4), 8060919 (4) (see all 48)
    nasal polyps 75.3 28 12916352 (3), 15935609 (2), 10852530 (2), 11435734 (2) (see all 15)
    keratoconjunctivitis vernal 74.1 7 8588697 (2), 7800361 (2), 10682966 (1), 9135403 (1) (see all 5)

    Genetic Association Database (GAD): RNASE3
    Human Genome Epidemiology (HuGE) Navigator: RNASE3 (8 documents)

    Export disorders for RNASE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASE3 gene, integrated from 9 sources (see all 1281):
    (articles sorted by number of sources associating them with RNASE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. (PubMed id 16014847)1, 4, 9 Kim Y.J....Nutman T.B. (2005)
    2. The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site. (PubMed id 12356310)1, 2, 9 Mohan C.G.... Acharya K.R. (2002)
    3. Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. (PubMed id 2387583)1, 2, 9 Hamann K.J.... Barker R.L. (1990)
    4. Sequence variation at two eosinophil-associated ribonuclease loci in humans. (PubMed id 11102386)1, 2, 9 Zhang J. and Rosenberg H.F. (2000)
    5. Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution. (PubMed id 10903870)1, 2, 9 Mallorqui-Fernandez G....Coll M. (2000)
    6. Crystal structure of eosinophil cationic protein at 2.4 A resolution. (PubMed id 10606511)1, 2, 9 Boix E....Acharya K.R. (1999)
    7. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. (PubMed id 1577491)1, 3, 9 Mastrianni D.M.... Ackerman S.J. (1992)
    8. Bactericidal and membrane disruption activities of th e eosinophil cationic protein are largely retained in an N-terminal fragment. (PubMed id 19450231)1, 2 Torrent M....Boix E. (2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms. (PubMed id 12100059)1, 4 Jonsson U.B....Venge P. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6037 HGNC: 10046 AceView: RNASE3 Ensembl:ENSG00000169397 euGenes: HUgn6037
    ECgene: RNASE3 Kegg: 6037 H-InvDB: RNASE3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNASE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNASE3 gene:
    Search GeneIP for patents involving RNASE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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