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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE3 Gene

protein-coding   GIFtS: 59
GCID: GC14P021359

Ribonuclease, RNase A Family, 3


(Previous symbol: RNS3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, 31 2     RNase 32 3
RNS31 2 3 5     Cytotoxic Ribonuclease2
ECP2 3 5     EC 3.1.27.-3
Eosinophil Cationic Protein1 2     EC 3.1.278
Ribonuclease 32 3     EC 3.1.27.58

External Ids:    HGNC: 100461   Entrez Gene: 60372   Ensembl: ENSG000001693977   OMIM: 1313985   UniProtKB: P127243   

Export aliases for RNASE3 gene to outside databases

Previous GC identifers: GC14P018731 GC14P015146 GC14P019349 GC14P020429 GC14P001480


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNASE3 Gene: 
RNASE3 (ribonuclease, RNase A family, 3) is a protein-coding gene. Diseases associated with RNASE3 include bronchitis, and food allergy, and among its related super-pathways are Allograft rejection. GO annotations related to this gene include ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE8.

UniProtKB/Swiss-Prot: ECP_HUMAN, P12724
Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of
biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of
preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment,
alteration of the overall cell shape and partial loss of cell content

Gene Wiki entry for RNASE3 (Eosinophil cationic protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE3 gene promoter:
         AML1a   Lmo2   NF-kappaB   C/EBPalpha   Evi-1   CHOP-10   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE3 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASE3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24-q31   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q24-q31

RNASE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021359:  view genomic region     (about GC identifiers)

Start:
21,359,558 bp from pter      End:
21,360,507 bp from pter
Size:
950 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ECP_HUMAN, P12724 (See protein sequence)
Recommended Name: Eosinophil cationic protein precursor  
Size: 160 amino acids; 18385 Da
Subunit: Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with
and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In
vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7
Subcellular location: Secreted. Note=Located in the matrix of eosinophil large specific granule, which are
released following activation by an immune stimulus
6 PDB 3D structures from and Proteopedia for RNASE3:
1DYT (3D)        1H1H (3D)        1QMT (3D)        2KB5 (3D)        4A2O (3D)        4A2Y (3D)    
Secondary accessions: Q4VBC1 Q8WTP7 Q8WZ62 Q9GZN9

Explore the universe of human proteins at neXtProt for RNASE3: NX_P12724

Explore proteomics data for RNASE3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12724

  • 4/6 DME Specific Peptides for RNASE3 (P12724) (see all 6)
     VACDNRD  VVNVCGN  YPVVPVHLD  RCKNQNTFL 

    RNASE3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RNASE3 Protein Expression
    REFSEQ proteins: NP_002926.2  
    ENSEMBL proteins: 
     ENSP00000302324  

    Human Recombinant Protein Products for RNASE3: 
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    Novus Biologicals RNASE3 Protein
    Novus Biologicals RNASE3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RNASE3
    Cloud-Clone Corp. Proteins for RNASE3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    RNASE3 for ontologies           About GeneDecksing



    RNASE3 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for RNASE3 
    Cloud-Clone Corp. CLIAs for RNASE3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P12724

    ProtoNet protein and cluster: P12724

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: ECP_HUMAN, P12724
    Similarity: Belongs to the pancreatic ribonuclease family


    RNASE3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ECP_HUMAN, P12724
    Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of
    biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of
    preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment,
    alteration of the overall cell shape and partial loss of cell content

         Genatlas biochemistry entry for RNASE3:
    ribonuclease RNAse A family,3,eosinophil cationic protein

         Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0004540ribonuclease activity TAS2745977
         
    RNASE3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE3 
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    Inhib. RNA
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    Sirion Biotech Customized adenovirus for overexpression of RNASE3

    Clone
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    OriGene ORF clones in mouse, rat for RNASE3
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RNASE3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Asthma0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1         Kegg Pathway  (Kegg details for RNASE3):
        Asthma


    RNASE3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNASE3

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process TAS2745977
    GO:0042742defense response to bacterium IEA--

    RNASE3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNASE3 for compounds           About GeneDecksing

    EMD Millipore small molecules for RNASE3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASE3 (ECP)

    3 DrugBank Compounds for RNASE3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pranlukast-- 103177-37-3targetother/unknown10028377 15136379 11476469 10804983
    Adenosine-2'-5'-Diphosphate-- --target--17139284 17016423
    Citric Acid-- 77-92-9target--17139284 17016423

    10/112 Novoseek inferred chemical compound relationships for RNASE3 gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methacholine 82.1 95 12549774 (2), 8874658 (2), 7982122 (2), 17537187 (2) (see all 62)
    histamine 77.9 252 8622322 (5), 8568122 (4), 10453855 (4), 9390492 (4) (see all 99)
    unicap 77.9 10 15934281 (1), 16124647 (1), 17040428 (1), 17205697 (1) (see all 9)
    budesonide 69.8 37 12452208 (3), 8335852 (3), 1430701 (2), 10384060 (2) (see all 19)
    montelukast 68.6 26 20112601 (4), 11842294 (4), 12736396 (3), 10588996 (2) (see all 14)
    fluticasone propionate 68 29 9690571 (3), 11167349 (2), 12823118 (2), 17446966 (1) (see all 17)
    allergens 67 37 9591438 (2), 9893184 (2), 8603280 (1), 10536888 (1) (see all 24)
    pranlukast 65.7 17 11796443 (3), 11476469 (2), 10028377 (1), 10848924 (1) (see all 7)
    lte4 63 32 17339866 (4), 10542994 (3), 11393122 (2), 11551254 (2) (see all 9)
    ltc4 60.3 38 8130655 (4), 16450573 (3), 9821474 (2), 8790750 (2) (see all 17)

    Search CenterWatch for drugs/clinical trials and news about RNASE3 / ECP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RNASE3 gene: 
    NM_002935.2  

    Unigene Cluster for RNASE3:

    Ribonuclease, RNase A family, 3
    Hs.73839  [show with all ESTs]
    Unigene Representative Sequence: DN998783
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304639(uc001vyj.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RNASE3
    SwitchGear 3'UTR luciferase reporter plasmidRNASE3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RNASE3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE3
    Clone
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    OriGene clones in human, mouse for RNASE3 (see all 7)
    OriGene ORF clones in mouse, rat for RNASE3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE3 (NM_002935)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE3
    Sirion Biotech Customized lentivirus for stable overexpression of RNASE3 
                         Customized lentivirus expression plasmids for stable overexpression of RNASE3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RNASE3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE3

    Additional mRNA sequence: 

    BC096060.1 BC096061.3 BC096062.3 M28128.1 X15161.1 

    1 DOTS entry:

    DT.408898 

    12 AceView cDNA sequences:

    BI028557 NM_002935 BX280390 BM714612 AJ705510 AA587166 X15161 M28128 
    BF895434 BI030233 BF902198 AW075940 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASE3 expression in normal human tissues (normalized intensities)      RNASE3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNASE3 Expression
    About this image


    RNASE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 7 entries
             Bone marrow-derived hematopoietic stem cells
             Bone Marrow CD105+ Cells   
             bone marrow   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             bone marrow   
     
     Liver (Hepatobiliary System)
             Fetal Liver CD34+ Cells   

    See RNASE3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNASE3

    SOURCE GeneReport for Unigene cluster: Hs.73839
        SABiosciences Expression via Pathway-Focused PCR Array including RNASE3: 
              Allergy & Asthma in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE3 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ear141 , 5 eosinophil-associated, ribonuclease A family, member 14 less1, 5 60.22(n)1
    48.67(a)1
      14 (26.42 cM)5
    5038471  NM_017389.21  NP_059085.21 
     512036955 
    chicken
    (Gallus gallus)
    Aves RSFR6
    ANG6
    (see all 3)
    Angiogenin
    (see all 3)
    23(a)
    23(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(8804970-8806179)
    6(8796401-8797835)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    28(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343220.1(1438299-1438661)
    GL343220.1(1531632-1532063)


    ENSEMBL Gene Tree for RNASE3 (if available)
    TreeFam Gene Tree for RNASE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNASE3 gene
    RNASE82  RNASE72  RNASE22  RNASE12  ANG2  RNASE62  RNASE42  
    5 SIMAP similar genes for RNASE3 using alignment to 1 protein entry:     ECP_HUMAN:
    RNASE2    ECRP    RNASE7    RNASE6    RNASE8

    RNASE3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/125 SNPs in RNASE3 are shown (see all 125)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172930181,2
    C,F--21357609(+) GTCTTC/TAGGAG 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs1150413911,2
    C,F--21357641(+) ACAGAT/CAGGAT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1501025551,2
    --21357665(+) GAGAGC/TGGAGT 1 -- us2k10--------
    rs1140808031,2
    C,F--21357668(+) AGTGGA/GGTCAG 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs767647401,2
    C,F--21357669(+) GTGGAG/ATCAGA 1 -- us2k11Minor allele frequency- A:0.12EA 120
    rs1170199621,2
    C,F--21357686(+) CCCTGA/CGCTAG 1 -- us2k11Minor allele frequency- C:0.12EA 120
    rs755593511,2
    C,F--21357707(+) ACAGAC/TGCAGC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs619803621,2
    C,F--21357708(+) CAGACG/ACAGCT 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1166524471,2
    C,F--21357744(+) ACCAAT/CGGTGC 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs285325331,2
    C,F--21357845(+) AACATC/TATAAA 1 -- us2k13Minor allele frequency- T:0.20NA WA 122

    HapMap Linkage Disequilibrium report for RNASE3 (21359558 - 21360507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for RNASE3 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673725CNV Deletion23128226
    nsv436831CNV Insertion17901297
    nsv1205CNV Insertion18451855
    nsv498822CNV Loss21111241
    nsv433274CNV Loss18776910
    nsv1204CNV Loss18451855
    nsv470622CNV Loss18288195
    dgv1851n71CNV Loss21882294
    esv29488CNV Loss19812545
    dgv363n67CNV Gain20364138


    Human Gene Mutation Database (HGMD): RNASE3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 131398    OMIM disorders: --

    20/120 diseases for RNASE3 (see all 120):    About MalaCards
    bronchitis    food allergy    schistosomiasis    otitis media
    churg-strauss syndrome    cough variant asthma    kimura disease    chronic eosinophilic pneumonia
    pulmonary eosinophilia    toxocariasis    collagenous colitis    eosinophilic cystitis
    anisakiasis    chronic maxillary sinusitis    helminthiasis    endocarditis
    loeffler endocarditis    elephantiasis    chronic rhinitis    eosinophilia

    12 diseases from the University of Copenhagen DISEASES database for RNASE3:
    Asthma     Allergic rhinitis     Eosinophilia     Hypersensitivity reaction type I disease
    Atopic dermatitis     Common cold     Bronchiolitis     Churg-Strauss syndrome
    Conjunctivitis     Keratoconjunctivitis     Bronchitis     Urticaria

    RNASE3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/97 Novoseek inferred disease relationships for RNASE3 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 88.7 778 8717287 (8), 8857106 (7), 7894629 (6), 2053855 (5) (see all 99)
    allergic rhinitis 84.3 78 19760211 (4), 12889102 (4), 8203234 (3), 11019593 (2) (see all 44)
    inflammation 82.8 283 10520059 (5), 10353094 (4), 10520078 (3), 7547335 (3) (see all 99)
    eosinophilia 82.4 83 16340277 (4), 14533663 (3), 9130522 (2), 8744107 (2) (see all 54)
    rhinitis 81.2 78 9578915 (4), 10522945 (3), 11468003 (3), 16521419 (3) (see all 38)
    rhinitis allergic seasonal 81.1 32 10857776 (3), 15934281 (2), 10232439 (2), 7499684 (1) (see all 20)
    asthma allergic 79.3 19 8648010 (2), 1373987 (2), 8947065 (1), 9578914 (1) (see all 16)
    dermatitis atopic 75.4 114 9558841 (5), 10520078 (4), 7894629 (4), 8060919 (4) (see all 48)
    nasal polyps 75.3 28 12916352 (3), 15935609 (2), 10852530 (2), 11435734 (2) (see all 15)
    keratoconjunctivitis vernal 74.1 7 8588697 (2), 7800361 (2), 10682966 (1), 9135403 (1) (see all 5)

    Genetic Association Database (GAD): RNASE3
    Human Genome Epidemiology (HuGE) Navigator: RNASE3 (8 documents)

    Export disorders for RNASE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASE3 gene, integrated from 9 sources (see all 1288):
    (articles sorted by number of sources associating them with RNASE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes. (PubMed id 17362255)1, 4, 9 Munthe-Kaas M.C....Carlsen K.L. (2007)
    2. Identification of polymorphisms in the RNase3 gene an d the association with allergic rhinitis. (PubMed id 19760211)1, 4, 9 Kang I....Lee J.H. (2010)
    3. Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany. (PubMed id 19014520)1, 4, 9 Parwez Q....Hoffjan S. (2008)
    4. Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. (PubMed id 16014847)1, 4, 9 Kim Y.J....Nutman T.B. (2005)
    5. The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site. (PubMed id 12356310)1, 2, 9 Mohan C.G.... Acharya K.R. (2002)
    6. Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. (PubMed id 2387583)1, 2, 9 Hamann K.J.... Barker R.L. (1990)
    7. Sequence variation at two eosinophil-associated ribonuclease loci in humans. (PubMed id 11102386)1, 2, 9 Zhang J. and Rosenberg H.F. (2000)
    8. Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution. (PubMed id 10903870)1, 2, 9 Mallorqui-Fernandez G....Coll M. (2000)
    9. Crystal structure of eosinophil cationic protein at 2.4 A resolution. (PubMed id 10606511)1, 2, 9 Boix E....Acharya K.R. (1999)
    10. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. (PubMed id 1577491)1, 3, 9 Mastrianni D.M.... Ackerman S.J. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6037 HGNC: 10046 AceView: RNASE3 Ensembl:ENSG00000169397 euGenes: HUgn6037
    ECgene: RNASE3 Kegg: 6037 H-InvDB: RNASE3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNASE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RNASE3 gene:
    Search GeneIP for patents involving RNASE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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