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RNASE3 Gene

protein-coding   GIFtS: 60
GCID: GC14P021359

Ribonuclease, RNase A Family, 3


(Previous symbol: RNS3)
  See RNASE3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease, RNase A Family, 31 2     RNase 32 3
RNS31 2 3 5     Cytotoxic Ribonuclease2
ECP2 3 5     EC 3.1.27.-3
Eosinophil Cationic Protein1 2     EC 3.1.278
Ribonuclease 32 3     EC 3.1.27.58

External Ids:    HGNC: 100461   Entrez Gene: 60372   Ensembl: ENSG000001693977   OMIM: 1313985   UniProtKB: P127243   

Export aliases for RNASE3 gene to outside databases

Previous GC identifers: GC14P018731 GC14P015146 GC14P019349 GC14P020429 GC14P001480


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNASE3 Gene:
RNASE3 (ribonuclease, RNase A family, 3) is a protein-coding gene. Diseases associated with RNASE3 include bronchitis, and toxocariasis. GO annotations related to this gene include ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE8.

UniProtKB/Swiss-Prot: ECP_HUMAN, P12724
Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of
biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of
preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment,
alteration of the overall cell shape and partial loss of cell content

Gene Wiki entry for RNASE3 (Eosinophil cationic protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE3 gene promoter:
         AML1a   Lmo2   NF-kappaB   C/EBPalpha   Evi-1   CHOP-10   PPAR-gamma1   PPAR-gamma2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE3 promoter sequence
   Search Chromatin IP Primers for RNASE3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

RNASE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE3 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021359:  view genomic region     (about GC identifiers)

Start:
21,359,558 bp from pter      End:
21,360,507 bp from pter
Size:
950 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ECP_HUMAN, P12724 (See protein sequence)
Recommended Name: Eosinophil cationic protein precursor  
Size: 160 amino acids; 18385 Da
Subunit: Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with
and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In
vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7
Selected PDB 3D structures from and Proteopedia for RNASE3 (see all 7):
1DYT (3D)        1H1H (3D)        1QMT (3D)        2KB5 (3D)        2LVZ (3D)        4A2O (3D)    
Secondary accessions: Q4VBC1 Q8WTP7 Q8WZ62 Q9GZN9

Explore the universe of human proteins at neXtProt for RNASE3: NX_P12724

Explore proteomics data for RNASE3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn84, Asn92, Asn119
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNASE3 (P12724) (see all 6)
     VACDNRD  VVNVCGN  YPVVPVHLD  RCKNQNTFL 


    See RNASE3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002926.2  
    ENSEMBL proteins: 
     ENSP00000302324  

    RNASE3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RNASE3
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    OriGene Custom Protein Services for RNASE3
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    Novus Biologicals RNASE3 Protein
    Novus Biologicals RNASE3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RNASE3
    Cloud-Clone Corp. Proteins for RNASE3

     
    Search eBioscience for Proteins for RNASE3 

     
    antibodies-online proteins for RNASE3 (10 products) 

     
    antibodies-online peptides for RNASE3

    RNASE3 Antibody Products:

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    antibodies-online antibodies for RNASE3 (47 products) 

    RNASE3 Assay Products:

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    Cloud-Clone Corp. ELISAs for RNASE3
    Cloud-Clone Corp. CLIAs for RNASE3
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    antibodies-online kits for RNASE3 (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P12724

    ProtoNet protein and cluster: P12724

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: ECP_HUMAN, P12724
    Similarity: Belongs to the pancreatic ribonuclease family


    Find genes that share domains with RNASE3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ECP_HUMAN, P12724
    Function: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of
    biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of
    preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment,
    alteration of the overall cell shape and partial loss of cell content

         Genatlas biochemistry entry for RNASE3:
    ribonuclease RNAse A family,3,eosinophil cationic protein

         Enzyme Numbers (IUBMB): EC 3.1.27.52 EC 3.1.272 EC 3.1.27.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004540ribonuclease activity TAS2745977
    GO:0016892endoribonuclease activity, producing 3'-phosphomonoesters IEA--
         
    Find genes that share ontologies with RNASE3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNASE3

    miRNA
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    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RNASE3
    Predesigned siRNA for gene silencing in human, mouse, rat RNASE3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for RNASE3 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: RNASE3 (NM_002935)
    Sino Biological Human cDNA Clone for RNASE3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RNASE3
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNASE3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ECP_HUMAN, P12724: Secreted. Note=Located in the matrix of eosinophil large specific granule, which are
    released following activation by an immune stimulus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with RNASE3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RNASE3 About    
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Asthma0.46


    Find genes that share SuperPaths with RNASE3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for RNASE3):
        Asthma

        Pathway & Disease-focused RT2 Profiler PCR Array including RNASE3: 
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNASE3

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process TAS2745977
    GO:0042742defense response to bacterium IEA--
    GO:0090501RNA phosphodiester bond hydrolysis TAS2745977

    Find genes that share ontologies with RNASE3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASE3 (ECP)

    3 DrugBank Compounds for RNASE3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pranlukast-- 103177-37-3targetother/unknown10028377 15136379 11476469 10804983
    Adenosine-2'-5'-Diphosphate-- --target--17139284 17016423
    Citric Acid-- 77-92-9target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for RNASE3 gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methacholine 82.1 95 12549774 (2), 8874658 (2), 7982122 (2), 17537187 (2) (see all 62)
    histamine 77.9 252 8622322 (5), 8568122 (4), 10453855 (4), 9390492 (4) (see all 99)
    unicap 77.9 10 15934281 (1), 16124647 (1), 17040428 (1), 17205697 (1) (see all 9)
    budesonide 69.8 37 12452208 (3), 8335852 (3), 1430701 (2), 10384060 (2) (see all 19)
    montelukast 68.6 26 20112601 (4), 11842294 (4), 12736396 (3), 10588996 (2) (see all 14)
    fluticasone propionate 68 29 9690571 (3), 11167349 (2), 12823118 (2), 17446966 (1) (see all 17)
    allergens 67 37 9591438 (2), 9893184 (2), 8603280 (1), 10536888 (1) (see all 24)
    pranlukast 65.7 17 11796443 (3), 11476469 (2), 10028377 (1), 10848924 (1) (see all 7)
    lte4 63 32 17339866 (4), 10542994 (3), 11393122 (2), 11551254 (2) (see all 9)
    ltc4 60.3 38 8130655 (4), 16450573 (3), 9821474 (2), 8790750 (2) (see all 17)



    Find genes that share compounds with RNASE3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNASE3 gene: 
    NM_002935.2  

    Unigene Cluster for RNASE3:

    Ribonuclease, RNase A family, 3
    Hs.73839  [show with all ESTs]
    Unigene Representative Sequence: DN998783
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304639(uc001vyj.3)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNASE3
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    GenScript: all cDNA clones in your preferred vector: RNASE3 (NM_002935)
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    Primer
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    OriGene qPCR primer pairs and template standards for RNASE3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE3
      QuantiTect SYBR Green Assays in human, mouse, rat RNASE3
      QuantiFast Probe-based Assays in human, mouse, rat RNASE3

    Additional mRNA sequence: 

    BC096060.1 BC096061.3 BC096062.3 M28128.1 X15161.1 

    1 DOTS entry:

    DT.408898 

    12 AceView cDNA sequences:

    BI028557 BX280390 NM_002935 AJ705510 X15161 BM714612 AA587166 M28128 
    BI030233 BF902198 BF895434 AW075940 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASE3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RNASE3 Expression
    About this image


    RNASE3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
             Bone marrow-derived hematopoietic stem cells (family)
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Ovary (Reproductive System)
             Oviduct
    RNASE3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASE3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.73839
        Pathway & Disease-focused RT2 Profiler PCR Array including RNASE3: 
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE3 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ear145 eosinophil-associated, ribonuclease A family, member more   --   14 (26.42 cM) 51203695 
    chicken
    (Gallus gallus)
    Aves ANG6
    RSFR6
    (see all 3)
    Gallus gallus angiogenin, ribonuclease, RNase A fa...
    Gallus gallus leukocyte ribonuclease A-2 (RSFR), m...
    (see all 3)
    24(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(8796401-8797835)
    6(8804970-8806179)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    24(a)
    23(a)
    many ↔ many
    many ↔ many
    GL343220.1(1531632-1532063)
    GL343220.1(1279015-1279452)


    ENSEMBL Gene Tree for RNASE3 (if available)
    TreeFam Gene Tree for RNASE3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNASE3 gene
    RNASE82  RNASE72  RNASE22  RNASE12  ANG2  RNASE62  RNASE42  
    5 SIMAP similar genes for RNASE3 using alignment to 1 protein entry:     ECP_HUMAN:
    RNASE2    ECRP    RNASE7    RNASE6    RNASE8

    Find genes that share paralogs with RNASE3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNASE3 (see all 125)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1172930181,2
    C,F--21357609(+) GTCTTC/TAGGAG 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs1150413911,2
    C,F--21357641(+) ACAGAT/CAGGAT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1501025551,2
    --21357665(+) GAGAGC/TGGAGT 1 -- us2k10--------
    rs1140808031,2
    C,F--21357668(+) AGTGGA/GGTCAG 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs767647401,2
    C,F--21357669(+) GTGGAG/ATCAGA 1 -- us2k11Minor allele frequency- A:0.12EA 120
    rs1170199621,2
    C,F--21357686(+) CCCTGA/CGCTAG 1 -- us2k11Minor allele frequency- C:0.12EA 120
    rs755593511,2
    C,F--21357707(+) ACAGAC/TGCAGC 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs619803621,2
    C,F--21357708(+) CAGACG/ACAGCT 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1166524471,2
    C,F--21357744(+) ACCAAT/CGGTGC 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs285325331,2
    C,F--21357845(+) AACATC/TATAAA 1 -- us2k13Minor allele frequency- T:0.20NA WA 122

    HapMap Linkage Disequilibrium report for RNASE3 (21359558 - 21360507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNASE3 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673725CNV Deletion23128226
    nsv436831CNV Insertion17901297
    nsv1205CNV Insertion18451855
    nsv498822CNV Loss21111241
    nsv433274CNV Loss18776910
    nsv1204CNV Loss18451855
    nsv470622CNV Loss18288195
    dgv1851n71CNV Loss21882294
    esv29488CNV Loss19812545
    dgv363n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): RNASE3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASE3
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 131398    OMIM disorders: --

    Selected diseases for RNASE3 (see all 51):    
    About MalaCards
    bronchitis    toxocariasis    collagenous colitis    chronic eosinophilic pneumonia
    cough variant asthma    helminthiasis    schistosomiasis    eosinophilic cystitis
    kimura disease    food allergy    sinusitis    anisakiasis
    churg-strauss syndrome    elephantiasis    chronic rhinitis    chronic maxillary sinusitis
    bronchiolitis    intrinsic asthma    eosinophilic pneumonia    pulmonary eosinophilia

    12 diseases from the University of Copenhagen DISEASES database for RNASE3:
    Asthma     Allergic rhinitis     Eosinophilia     Hypersensitivity reaction type I disease
    Atopic dermatitis     Common cold     Bronchiolitis     Churg-Strauss syndrome
    Conjunctivitis     Keratoconjunctivitis     Bronchitis     Urticaria

    Find genes that share disorders with RNASE3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RNASE3 gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 88.7 778 8717287 (8), 8857106 (7), 7894629 (6), 2053855 (5) (see all 99)
    allergic rhinitis 84.3 78 19760211 (4), 12889102 (4), 8203234 (3), 11019593 (2) (see all 44)
    inflammation 82.8 283 10520059 (5), 10353094 (4), 10520078 (3), 7547335 (3) (see all 99)
    eosinophilia 82.4 83 16340277 (4), 14533663 (3), 9130522 (2), 8744107 (2) (see all 54)
    rhinitis 81.2 78 9578915 (4), 10522945 (3), 11468003 (3), 16521419 (3) (see all 38)
    rhinitis allergic seasonal 81.1 32 10857776 (3), 15934281 (2), 10232439 (2), 7499684 (1) (see all 20)
    asthma allergic 79.3 19 8648010 (2), 1373987 (2), 8947065 (1), 9578914 (1) (see all 16)
    dermatitis atopic 75.4 114 9558841 (5), 10520078 (4), 7894629 (4), 8060919 (4) (see all 48)
    nasal polyps 75.3 28 12916352 (3), 15935609 (2), 10852530 (2), 11435734 (2) (see all 15)
    keratoconjunctivitis vernal 74.1 7 8588697 (2), 7800361 (2), 10682966 (1), 9135403 (1) (see all 5)

    Genetic Association Database (GAD): RNASE3
    Human Genome Epidemiology (HuGE) Navigator: RNASE3 (8 documents)

    Export disorders for RNASE3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNASE3 gene, integrated from 10 sources (see all 1293):
    (articles sorted by number of sources associating them with RNASE3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes. (PubMed id 17362255)1, 4, 9 Munthe-Kaas M.C....Carlsen K.L. (Allergy 2007)
    2. Identification of polymorphisms in the RNase3 gene and the association with allergic rhinitis. (PubMed id 19760211)1, 4, 9 Kang I....Lee J.H. (Eur Arch Otorhinolaryngol 2010)
    3. Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany. (PubMed id 19014520)1, 4, 9 Parwez Q....Hoffjan S. (J Negat Results Biomed 2008)
    4. Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. (PubMed id 16014847)1, 4, 9 Kim Y.J....Nutman T.B. (Am. J. Trop. Med. Hyg. 2005)
    5. The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site. (PubMed id 12356310)1, 2, 9 Mohan C.G.... Acharya K.R. (Biochemistry 2002)
    6. Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. (PubMed id 2387583)1, 2, 9 Hamann K.J.... Barker R.L. (Genomics 1990)
    7. Sequence variation at two eosinophil-associated ribonuclease loci in humans. (PubMed id 11102386)1, 2, 9 Zhang J. and Rosenberg H.F. (Genetics 2000)
    8. Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution. (PubMed id 10903870)1, 2, 9 Mallorqui-Fernandez G....Coll M. (J. Mol. Biol. 2000)
    9. Crystal structure of eosinophil cationic protein at 2.4 A resolution. (PubMed id 10606511)1, 2, 9 Boix E....Acharya K.R. (Biochemistry 1999)
    10. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. (PubMed id 1577491)1, 3, 9 Mastrianni D.M.... Ackerman S.J. (Genomics 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6037 HGNC: 10046 AceView: RNASE3 Ensembl:ENSG00000169397 euGenes: HUgn6037
    ECgene: RNASE3 Kegg: 6037 H-InvDB: RNASE3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNASE3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNASE3 gene:
    Search GeneIP for patents involving RNASE3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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