Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNASE3 Gene

Aliases for RNASE3 Gene

  • Ribonuclease A Family Member 3 2 3 5
  • Ribonuclease, RNase A Family, 3 2 3
  • Eosinophil Cationic Protein 2 3
  • Ribonuclease 3 3 4
  • RNase 3 3 4
  • RNS3 3 4
  • ECP 3 4
  • Cytotoxic Ribonuclease 3
  • EC 3.1.27.5 61
  • EC 3.1.27.- 4
  • EC 3.1.27 61
  • RAF1 3

External Ids for RNASE3 Gene

Previous HGNC Symbols for RNASE3 Gene

  • RNS3

Previous GeneCards Identifiers for RNASE3 Gene

  • GC14P018731
  • GC14P015146
  • GC14P019349
  • GC14P020429
  • GC14P021359
  • GC14P001480

Summaries for RNASE3 Gene

Entrez Gene Summary for RNASE3 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE3 Gene

RNASE3 (Ribonuclease A Family Member 3) is a Protein Coding gene. Diseases associated with RNASE3 include Allergic Rhinitis and Rhinitis. Among its related pathways are Immune System and Allograft rejection. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE2.

UniProtKB/Swiss-Prot for RNASE3 Gene

  • Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.

Gene Wiki entry for RNASE3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE3 Gene

Genomics for RNASE3 Gene

Regulatory Elements for RNASE3 Gene

Enhancers for RNASE3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020426 1.5 FANTOM5 Ensembl ENCODE 1.4 -462.6 -462619 4.0 ELF3 ARID4B ZNF48 RAD21 RARA EGR1 ETV6 FOS CREM MIXL1 OSGEP PNP TMEM55B APEX1 RNASE11 TEP1 KLHL33 RNASE6 RNASE3 GC14P020415
GH14F020904 0.5 ENCODE 0.4 +13.2 13188 0.2 ZNF121 CTCF RAD21 ENSG00000136315 RNASE3 ECRP
GH14F020918 0.6 Ensembl 0.3 +27.8 27805 1.2 ZNF362 PKNOX1 NFIA CEBPA CEBPB CEBPG ECRP RNASE3
GH14F020890 0.2 Ensembl 0.8 +0.2 198 1.2 ENSG00000136315 RNASE3 ECRP
GH14F020881 0.4 Ensembl 0.4 -9.9 -9899 1.0 IKZF1 SPI1 ENSG00000258642 RNASE3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE3 Gene

Chromosome:
14
Start:
20,891,399 bp from pter
End:
20,892,348 bp from pter
Size:
950 bases
Orientation:
Plus strand

Genomic View for RNASE3 Gene

Genes around RNASE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE3 Gene

Proteins for RNASE3 Gene

  • Protein details for RNASE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12724-ECP_HUMAN
    Recommended name:
    Eosinophil cationic protein
    Protein Accession:
    P12724
    Secondary Accessions:
    • Q4VBC1
    • Q8WTP7
    • Q8WZ62
    • Q9GZN9

    Protein attributes for RNASE3 Gene

    Size:
    160 amino acids
    Molecular mass:
    18385 Da
    Quaternary structure:
    • Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.

    Three dimensional structures from OCA and Proteopedia for RNASE3 Gene

neXtProt entry for RNASE3 Gene

Selected DME Specific Peptides for RNASE3 Gene

P12724:
  • RVPLLHCDLINPGAQNIS
  • VACDNRD
  • RCKNQNTFL
  • QICLLLLLGLMGVEGSLHARPPQFT
  • VVNVCGN
  • YPVVPVHLD

Post-translational modifications for RNASE3 Gene

  • Glycosylation at Asn 84, Asn 92, and Asn 119
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE3 Gene

Gene Families for RNASE3 Gene

Protein Domains for RNASE3 Gene

Suggested Antigen Peptide Sequences for RNASE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12724

UniProtKB/Swiss-Prot:

ECP_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE3: view

Function for RNASE3 Gene

Molecular function for RNASE3 Gene

GENATLAS Biochemistry:
ribonuclease RNAse A family,3,eosinophil cationic protein
UniProtKB/Swiss-Prot Function:
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.

Enzyme Numbers (IUBMB) for RNASE3 Gene

Gene Ontology (GO) - Molecular Function for RNASE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity TAS 2745977
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RNASE3: view

Phenotypes for RNASE3 Gene

genes like me logo Genes that share phenotypes with RNASE3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE3 Gene

Localization for RNASE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE3 Gene

Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE3 gene
Compartment Confidence
extracellular 5
lysosome 4
plasma membrane 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RNASE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS 10706854
GO:0005615 extracellular space IDA 12860195
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE3: view

Pathways & Interactions for RNASE3 Gene

SuperPathways for RNASE3 Gene

SuperPathway Contained pathways
1 Immune System
2 Allograft rejection
.44
genes like me logo Genes that share pathways with RNASE3: view

Pathways by source for RNASE3 Gene

2 Reactome pathways for RNASE3 Gene
1 KEGG pathway for RNASE3 Gene

Interacting Proteins for RNASE3 Gene

Selected Interacting proteins: P12724-ECP_HUMAN for RNASE3 Gene via IID

Gene Ontology (GO) - Biological Process for RNASE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006401 RNA catabolic process TAS 2745977
GO:0019731 antibacterial humoral response IDA 12860195
GO:0042742 defense response to bacterium IEA --
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with RNASE3: view

No data available for SIGNOR curated interactions for RNASE3 Gene

Drugs & Compounds for RNASE3 Gene

(51) Drugs for RNASE3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pranlukast Approved Pharma Antagonist, Target, other/unknown 3
Adenosine-2'-5'-Diphosphate Experimental Pharma Target 0
Citric Acid Vet_approved Nutra Agonist, Activator, Target 1106

(63) Additional Compounds for RNASE3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNASE3: view

Transcripts for RNASE3 Gene

mRNA/cDNA for RNASE3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE3 Gene

Ribonuclease, RNase A family, 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE3 Gene

No ASD Table

Relevant External Links for RNASE3 Gene

GeneLoc Exon Structure for
RNASE3
ECgene alternative splicing isoforms for
RNASE3

Expression for RNASE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE3 Gene

This gene is overexpressed in Whole Blood (x43.3).

Protein differential expression in normal tissues from HIPED for RNASE3 Gene

This gene is overexpressed in Neutrophil (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE3 Gene



Protein tissue co-expression partners for RNASE3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE3 Gene:

RNASE3

SOURCE GeneReport for Unigene cluster for RNASE3 Gene:

Hs.73839
genes like me logo Genes that share expression patterns with RNASE3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RNASE3 Gene

Orthologs for RNASE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ear1 35
  • 49 (a)
ManyToMany
Ear11 35
  • 49 (a)
ManyToMany
Ear10 35
  • 48 (a)
ManyToMany
Ear6 35
  • 48 (a)
ManyToMany
Ear2 35
  • 47 (a)
ManyToMany
Ear14 35
  • 46 (a)
ManyToMany
Ear5 35
  • 46 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANG 35
  • 24 (a)
ManyToMany
RSFR 35
  • 24 (a)
ManyToMany
CL2 35
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
Species where no ortholog for RNASE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE3 Gene

ENSEMBL:
Gene Tree for RNASE3 (if available)
TreeFam:
Gene Tree for RNASE3 (if available)

Paralogs for RNASE3 Gene

Paralogs for RNASE3 Gene

(5) SIMAP similar genes for RNASE3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNASE3: view

Variants for RNASE3 Gene

Sequence variations from dbSNP and Humsavar for RNASE3 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs111273485 -- 20,891,307(+) GACCA(C/T)GTGTC intron-variant, upstream-variant-2KB
rs111618029 -- 20,891,484(+) CAGGA(A/G)GGGCA intron-variant
rs112635084 -- 20,890,795(+) TGGAA(G/T)CAATA intron-variant, upstream-variant-2KB
rs112776305 -- 20,891,097(+) AGGGG(C/G)CTGCC intron-variant, upstream-variant-2KB
rs114080803 -- 20,889,509(+) AGTGG(A/G)GTCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE3 Gene

Variant ID Type Subtype PubMed ID
nsv9121 CNV gain+loss 18304495
nsv983967 CNV duplication 23825009
nsv832740 CNV gain 17160897
nsv817619 CNV gain 17921354
nsv563847 CNV loss 21841781
nsv517174 CNV gain+loss 19592680
nsv498822 CNV loss 21111241
nsv470622 CNV loss 18288195
nsv442680 CNV gain+loss 18776908
nsv436831 CNV insertion 17901297
nsv433274 CNV loss 18776910
nsv428293 CNV gain+loss 18775914
nsv1205 CNV insertion 18451855
nsv1204 CNV deletion 18451855
nsv1050170 CNV gain+loss 25217958
nsv1044554 CNV gain 25217958
esv3892467 CNV gain+loss 25118596
esv3584663 CNV loss 24956385
esv29488 CNV loss 19812545
esv2759972 CNV gain+loss 17122850
esv2673725 CNV deletion 23128226
esv2421825 OTHER complex 20811451
dgv381e214 CNV loss 21293372
dgv380e214 CNV gain 21293372
dgv363n67 CNV gain 20364138
dgv34e203 CNV gain+loss 21179565
dgv1802n100 CNV loss 25217958
dgv1801n100 CNV gain 25217958
dgv1800n100 CNV gain 25217958
dgv1799n100 CNV loss 25217958
dgv1798n100 CNV gain+loss 25217958

Variation tolerance for RNASE3 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE3 Gene

Human Gene Mutation Database (HGMD)
RNASE3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE3 Gene

Disorders for RNASE3 Gene

MalaCards: The human disease database

(86) MalaCards diseases for RNASE3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
allergic rhinitis
  • atopic rhinitis
rhinitis
  • runny nose
allergic conjunctivitis
  • conjunctivitis allergic
food allergy
  • food hypersensitivity
keratoconjunctivitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RNASE3

Genetic Association Database (GAD)
RNASE3
Human Genome Epidemiology (HuGE) Navigator
RNASE3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE3
genes like me logo Genes that share disorders with RNASE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE3 Gene

Publications for RNASE3 Gene

  1. Identification of polymorphisms in the RNase3 gene and the association with allergic rhinitis. (PMID: 19760211) Kang I. … Lee J.H. (Eur Arch Otorhinolaryngol 2010) 3 22 46 64
  2. Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes. (PMID: 17362255) Munthe-Kaas M.C. … Carlsen K.L. (Allergy 2007) 3 22 46 64
  3. The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site. (PMID: 12356310) Mohan C.G. … Acharya K.R. (Biochemistry 2002) 3 4 22 64
  4. The 434(G>C) polymorphism in the eosinophil cationic protein gene and its association with tissue eosinophilia in oral squamous cell carcinomas. (PMID: 19566743) Pereira M.C. … Kowalski L.P. (J. Oral Pathol. Med. 2010) 3 46 64
  5. Associations of ECP (eosinophil cationic protein)-gene polymorphisms to allergy, asthma, smoke habits and lung function in two Estonian and Swedish sub cohorts of the ECRHS II study. (PMID: 20534163) JAPnsson U.B. … Venge P. (BMC Pulm Med 2010) 3 46 64

Products for RNASE3 Gene

Sources for RNASE3 Gene

Content
Loading form....