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Aliases for RNASE2 Gene

Aliases for RNASE2 Gene

  • Ribonuclease A Family Member 2 2 3 5
  • Eosinophil-Derived Neurotoxin 2 3 4
  • Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin) 2 3
  • Ribonuclease US 3 4
  • Ribonuclease 2 3 4
  • RNase UpI-2 3 4
  • EC 3.1.27.5 4 61
  • RNase 2 3 4
  • RNS2 3 4
  • EDN 3 4
  • Non-Secretory Ribonuclease 3
  • Ribonuclease A F3 3
  • RAF3 3

External Ids for RNASE2 Gene

Previous HGNC Symbols for RNASE2 Gene

  • RNS2

Previous GeneCards Identifiers for RNASE2 Gene

  • GC14P018796
  • GC14P015210
  • GC14P019413
  • GC14P020493
  • GC14P021423
  • GC14P001544
  • GC14P021026
  • GC14P021038
  • GC14P021046
  • GC14P021052

Summaries for RNASE2 Gene

Entrez Gene Summary for RNASE2 Gene

  • The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE2 Gene

RNASE2 (Ribonuclease A Family Member 2) is a Protein Coding gene. Diseases associated with RNASE2 include Ladd Syndrome and Herpes Gestationis. Among its related pathways are Immune System. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot for RNASE2 Gene

  • This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.

Gene Wiki entry for RNASE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE2 Gene

Genomics for RNASE2 Gene

Regulatory Elements for RNASE2 Gene

Enhancers for RNASE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F020954 1 Ensembl ENCODE 0.8 -0.1 -52 1.6 GATAD2A NFIA HLF CEBPA CEBPB CEBPG HNF4A ENSG00000136315 METTL17 SLC39A2 RNASE1 TMEM253 ZNF219 RNASE2 LOC100507513
GH14F020960 0.7 Ensembl 0.4 +5.8 5750 0.8 CTCF ZNF384 RAD21 ZNF2 E2F1 PRDM10 ZSCAN29 TRIM24 KLF8 GATAD2A ENSG00000136315 APEX1 METTL3 RN7SL189P RNASE2
GH14F020945 0.2 Ensembl 0.4 -9.9 -9852 1.2 PKNOX1 MTA2 JUNB TRIM22 TBX21 ATF2 IKZF1 ETV6 CREM ENSG00000136315 ENSG00000259001 LOC100507513 RNASE2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RNASE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE2 Gene

Chromosome:
14
Start:
20,955,452 bp from pter
End:
20,956,436 bp from pter
Size:
985 bases
Orientation:
Plus strand

Genomic View for RNASE2 Gene

Genes around RNASE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE2 Gene

Proteins for RNASE2 Gene

  • Protein details for RNASE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10153-RNAS2_HUMAN
    Recommended name:
    Non-secretory ribonuclease
    Protein Accession:
    P10153
    Secondary Accessions:
    • Q52M39
    • Q9H2B7
    • Q9UCG7

    Protein attributes for RNASE2 Gene

    Size:
    161 amino acids
    Molecular mass:
    18354 Da
    Quaternary structure:
    • Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.

    Three dimensional structures from OCA and Proteopedia for RNASE2 Gene

neXtProt entry for RNASE2 Gene

Selected DME Specific Peptides for RNASE2 Gene

P10153:
  • QHINMTS
  • VACDNRD
  • RCKNQNTFL
  • VVNVCGN
  • YPVVPVHLD
  • QVPLIHCNLTTPS
  • QFTWAQWFE
  • VINNYQRRCK

Post-translational modifications for RNASE2 Gene

  • A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in pregnant women urine, from other nonsecretory RNases.
  • Glycosylation at Trp 34, Asn 44, Asn 86, Asn 92, Asn 111, and Asn 119
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE2 Gene

Gene Families for RNASE2 Gene

Protein Domains for RNASE2 Gene

Suggested Antigen Peptide Sequences for RNASE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10153

UniProtKB/Swiss-Prot:

RNAS2_HUMAN :
  • The N-terminal region is necessary for mediating chemotactic activity.
  • Belongs to the pancreatic ribonuclease family.
Domain:
  • The N-terminal region is necessary for mediating chemotactic activity.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE2: view

Function for RNASE2 Gene

Molecular function for RNASE2 Gene

GENATLAS Biochemistry:
ribonuclease RNAse A family,2,eosinophil-derived neurotoxin
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to nucleoside 3-phosphates and 3-phosphooligonucleotides ending in Cp or Up with 2,3-cyclic phosphate intermediates.
UniProtKB/Swiss-Prot Function:
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.

Enzyme Numbers (IUBMB) for RNASE2 Gene

Gene Ontology (GO) - Molecular Function for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004522 ribonuclease A activity IEA --
GO:0004540 ribonuclease activity TAS 2734298
genes like me logo Genes that share ontologies with RNASE2: view
genes like me logo Genes that share phenotypes with RNASE2: view

Animal Model Products

miRNA for RNASE2 Gene

miRTarBase miRNAs that target RNASE2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE2 Gene

Localization for RNASE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE2 Gene

Lysosome. Cytoplasmic granule. Note=Matrix of eosinophils large specific granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE2 Gene COMPARTMENTS Subcellular localization image for RNASE2 gene
Compartment Confidence
extracellular 5
lysosome 3
vacuole 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 2734298
GO:0005764 lysosome IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE2: view

Pathways & Interactions for RNASE2 Gene

SuperPathways for RNASE2 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with RNASE2: view

Pathways by source for RNASE2 Gene

2 Reactome pathways for RNASE2 Gene

Gene Ontology (GO) - Biological Process for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process TAS 2734298
GO:0006935 chemotaxis IEA,IDA 12855582
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASE2: view

No data available for SIGNOR curated interactions for RNASE2 Gene

Drugs & Compounds for RNASE2 Gene

(2) Drugs for RNASE2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine-2'-5'-Diphosphate Experimental Pharma Target 0
Adenosine-3'-5'-Diphosphate Experimental Pharma Target 0

(1) Additional Compounds for RNASE2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNASE2: view

Transcripts for RNASE2 Gene

mRNA/cDNA for RNASE2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE2 Gene

Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE2 Gene

No ASD Table

Relevant External Links for RNASE2 Gene

GeneLoc Exon Structure for
RNASE2
ECgene alternative splicing isoforms for
RNASE2

Expression for RNASE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE2 Gene

This gene is overexpressed in Whole Blood (x42.0).

Protein differential expression in normal tissues from HIPED for RNASE2 Gene

This gene is overexpressed in Urine (34.2), Spleen (7.7), and Neutrophil (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE2 Gene



Protein tissue co-expression partners for RNASE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE2 Gene:

RNASE2

SOURCE GeneReport for Unigene cluster for RNASE2 Gene:

Hs.728

mRNA Expression by UniProt/SwissProt for RNASE2 Gene:

P10153-RNAS2_HUMAN
Tissue specificity: Liver, lung, spleen, leukocytes and body fluids.
genes like me logo Genes that share expression patterns with RNASE2: view

Primer Products

Orthologs for RNASE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE2 34 35
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia RNASE3 34
  • 65.82 (n)
-- 35
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ear11 34 35
  • 64.57 (n)
Ear6 35
  • 51 (a)
ManyToMany
Ear1 35
  • 50 (a)
ManyToMany
Ear14 35
  • 50 (a)
ManyToMany
Ear5 35
  • 50 (a)
ManyToMany
Ear10 35
  • 49 (a)
ManyToMany
Ear2 35
  • 48 (a)
ManyToMany
Rnase2b 16
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANG 35
  • 25 (a)
ManyToMany
RSFR 35
  • 24 (a)
ManyToMany
CL2 35
  • 18 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 24 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
Species where no ortholog for RNASE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE2 Gene

ENSEMBL:
Gene Tree for RNASE2 (if available)
TreeFam:
Gene Tree for RNASE2 (if available)

Paralogs for RNASE2 Gene

Paralogs for RNASE2 Gene

(5) SIMAP similar genes for RNASE2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RNASE2 Gene

genes like me logo Genes that share paralogs with RNASE2: view

Variants for RNASE2 Gene

Sequence variations from dbSNP and Humsavar for RNASE2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10132319 -- 20,955,642(+) TTTGC(A/G)GACAG intron-variant
rs10142760 -- 20,954,909(+) AAAAT(C/T)CCTCA upstream-variant-2KB
rs10145713 -- 20,956,348(+) TATCA(A/G)CATCT utr-variant-3-prime
rs112248075 -- 20,955,679(+) TGGCC(A/G)CAGAG intron-variant
rs112496485 -- 20,955,462(+) AGTAG(A/G)GGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE2 Gene

Variant ID Type Subtype PubMed ID
dgv1798n100 CNV gain+loss 25217958
dgv1800n100 CNV gain 25217958
dgv1802n100 CNV loss 25217958
dgv34e203 CNV gain+loss 21179565
dgv3540n54 CNV loss 21841781
esv2759972 CNV gain+loss 17122850
nsv1044554 CNV gain 25217958
nsv1206 CNV insertion 18451855
nsv428293 CNV gain+loss 18775914
nsv456146 CNV loss 19166990
nsv470622 CNV loss 18288195
nsv514732 CNV gain 21397061
nsv527381 CNV gain 19592680
nsv563847 CNV loss 21841781
nsv826880 CNV gain 20364138
nsv826881 CNV gain 20364138
nsv832740 CNV gain 17160897
nsv9121 CNV gain+loss 18304495
nsv983967 CNV duplication 23825009

Variation tolerance for RNASE2 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE2 Gene

Disorders for RNASE2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RNASE2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ladd syndrome
  • lacrimoauriculodentodigital syndrome
herpes gestationis
  • gestational herpes
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RNASE2

Genetic Association Database (GAD)
RNASE2
Human Genome Epidemiology (HuGE) Navigator
RNASE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE2
genes like me logo Genes that share disorders with RNASE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE2 Gene

Publications for RNASE2 Gene

  1. Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations. (PMID: 18636464) Ueki M. … Yasuda T. (Cell Biochem. Funct. 2008) 3 22 46 64
  2. Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. (PMID: 15755456) Iyer S. … Acharya K.R. (J. Mol. Biol. 2005) 3 4 22 64
  3. Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2). (PMID: 12578357) Teufel D.P. … Shapiro R. (Biochemistry 2003) 3 4 22 64
  4. Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. (PMID: 12855582) Yang D. … Oppenheim J.J. (Blood 2003) 3 4 22 64
  5. Sequence variation at two eosinophil-associated ribonuclease loci in humans. (PMID: 11102386) Zhang J. … Rosenberg H.F. (Genetics 2000) 3 4 22 64

Products for RNASE2 Gene

Sources for RNASE2 Gene

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