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RNASE2 Gene

protein-coding   GIFtS: 56
GCID: GC14P021423

Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived...


(Previous symbol: RNS2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived
Neurotoxin)1 2
     RNase 22 3
RNS21 2 3 5     RNase UpI-22 3
EDN2 3 5     EC 3.1.27.53 8
Eosinophil-Derived Neurotoxin2 3     RAF32
Ribonuclease 22 3     Non-Secretory Ribonuclease2
Ribonuclease US2 3     Ribonuclease A F32

External Ids:    HGNC: 100451   Entrez Gene: 60362   Ensembl: ENSG000001693857   OMIM: 1314105   UniProtKB: P101533   

Export aliases for RNASE2 gene to outside databases

Previous GC identifers: GC14P018796 GC14P015210 GC14P019413 GC14P020493 GC14P001544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNASE2 Gene:
RNASE2 (ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)) is a protein-coding gene. GO annotations related to this gene include ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153
Function: This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for
U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of
biological activities

Gene Wiki entry for RNASE2 (Eosinophil-derived neurotoxin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE2 gene promoter:
         C/EBPbeta   MyoD   Lmo2   C/EBPalpha   NF-AT   Evi-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE2 promoter sequence
   Search Chromatin IP Primers for RNASE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

RNASE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021423:  view genomic region     (about GC identifiers)

Start:
21,423,611 bp from pter      End:
21,424,595 bp from pter
Size:
985 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153 (See protein sequence)
Recommended Name: Non-secretory ribonuclease precursor  
Size: 161 amino acids; 18354 Da
Subunit: Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur
Selected PDB 3D structures from and Proteopedia for RNASE2 (see all 11):
1GQV (3D)        1HI2 (3D)        1HI3 (3D)        1HI4 (3D)        1HI5 (3D)        1K2A (3D)    
Secondary accessions: Q52M39 Q9H2B7 Q9UCG7

Explore the universe of human proteins at neXtProt for RNASE2: NX_P10153

Explore proteomics data for RNASE2 at MOPED

Post-translational modifications: 

  • A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in
    pregnant women urine, from other nonsecretory RNases1
  • Glycosylation2 at Trp34, Asn44, Asn86, Asn92, Asn111, Asn119
  • Selected DME Specific Peptides for RNASE2 (P10153) (see all 8)
     VACDNRD  QHINMTS  VVNVCGN  YPVVPVHLD 


    See RNASE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002925.1  
    ENSEMBL proteins: 
     ENSP00000303276  

    RNASE2 Human Recombinant Protein Products:

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    Novus Biologicals RNASE2 Proteins
    Novus Biologicals RNASE2 Lysate
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    Cloud-Clone Corp. Proteins for RNASE2

     
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    LSBio Antibodies in human, mouse, rat for RNASE2

    RNASE2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for RNASE2
    Cloud-Clone Corp. CLIAs for RNASE2
    Search eBioscience for ELISAs for RNASE2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P10153

    ProtoNet protein and cluster: P10153

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153
    Domain: The N-terminal region is necessary for mediating chemotactic activity
    Similarity: Belongs to the pancreatic ribonuclease family


    Find genes that share domains with RNASE2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNAS2_HUMAN, P10153
    Function: This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for
    U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of
    biological activities
    Catalytic activity: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in
    Cp or Up with 2',3'-cyclic phosphate intermediates

         Genatlas biochemistry entry for RNASE2:
    ribonuclease RNAse A family,2,eosinophil-derived neurotoxin

         Enzyme Number (IUBMB): EC 3.1.27.51 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0004540ribonuclease activity TAS2734298
         
    Find genes that share ontologies with RNASE2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNASE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNASE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASE2

    miRNA
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    miRTarBase miRNAs that target RNASE2:
    hsa-mir-335-5p (MIRT018080)

    Block miRNA regulation of human, mouse, rat RNASE2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RNASE2
    SwitchGear 3'UTR luciferase reporter plasmidRNASE2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNASE2

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE2 (NM_002934)
    Sino Biological Human cDNA Clone for RNASE2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE2

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNAS2_HUMAN, P10153: Lysosome (Probable). Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    lysosome4
    vacuole4
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS2734298
    GO:0005764lysosome IEA--

    Find genes that share ontologies with RNASE2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including RNASE2: 
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RNASE2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RNASE2 (P101533 ENSP000003032764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCE1P612213, ENSP000002965774I2D: score=2 STRING: ENSP00000296577
    RNH1P134893, ENSP000003464024I2D: score=2 STRING: ENSP00000346402
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process TAS2734298
    GO:0006935chemotaxis IDA12855582
    GO:0090501RNA phosphodiester bond hydrolysis TAS2734298

    Find genes that share ontologies with RNASE2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASE2 (RNAS2)

    3 DrugBank Compounds for RNASE2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-2'-5'-Diphosphate-- --target--17139284 17016423
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423

    1 Novoseek inferred chemical compound relationship for RNASE2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butyrate 38.2 3 7616105 (1), 19279013 (1)



    Find genes that share compounds with RNASE2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNASE2 gene: 
    NM_002934.2  

    Unigene Cluster for RNASE2:

    Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
    Hs.728  [show with all ESTs]
    Unigene Representative Sequence: NM_002934
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304625(uc010aif.2 uc001vyl.1)
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RNASE2
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    GenScript: all cDNA clones in your preferred vector: RNASE2 (NM_002934)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE2
    Primer
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    OriGene qPCR primer pairs and template standards for RNASE2
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE2
      QuantiTect SYBR Green Assays in human, mouse, rat RNASE2
      QuantiFast Probe-based Assays in human, mouse, rat RNASE2

    Additional mRNA sequence: 

    BC093678.1 BC093680.1 BC096059.3 M24157.1 M28129.1 M30510.1 X55988.1 

    2 DOTS entries:

    DT.211183  DT.120782824 

    Selected AceView cDNA sequences (see all 34):

    BX279624 BF895386 NM_002934 AJ713186 M24157 BF892299 M30510 BI018358 
    X55988 M28129 AA984940 BF895383 BF905649 AA746216 BF894574 BF892545 
    BF904799 BF905650 BF935781 T86316 BF894582 BF902237 AV714039 BF895432 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACAACAGA
    RNASE2 Expression
    About this image


    RNASE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Cumulus Cells Antral Follicle
             Oviduct
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier
    RNASE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.728

    UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153
    Tissue specificity: Liver, lung, spleen, leukocytes and body fluids

        Pathway & Disease-focused RT2 Profiler PCR Array including RNASE2: 
              Allergy & Asthma in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RNASE2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ear111 , 5 eosinophil-associated, ribonuclease A family, member more1, 5 64.57(n)1
    51.18(a)1
      14 (26.44 cM)5
    937261  NM_053113.21  NP_444343.21 
     512552665 
    chicken
    (Gallus gallus)
    Aves ANG6
    RSFR6
    (see all 3)
    Gallus gallus angiogenin, ribonuclease, RNase A fa...
    Gallus gallus leukocyte ribonuclease A-2 (RSFR), m...
    (see all 3)
    25(a)
    24(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(8796401-8797835)
    6(8804970-8806179)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    24(a)
    21(a)
    many ↔ many
    many ↔ many
    GL343220.1(1531632-1532063)
    GL343220.1(1279015-1279452)


    ENSEMBL Gene Tree for RNASE2 (if available)
    TreeFam Gene Tree for RNASE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RNASE2 gene
    RNASE32  RNASE82  RNASE72  RNASE12  ANG2  RNASE62  RNASE42  
    5 SIMAP similar genes for RNASE2 using alignment to 1 protein entry:     RNAS2_HUMAN:
    ECRP    RNASE3    RNASE8    RNASE6    RNASE7

    Find genes that share paralogs with RNASE2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RNASE2
    PGOHUM00000261850


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RNASE2 (see all 113)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823457901,2
    --21421643(+) GTCTGA/CTGCGT 1 -- us2k10--------
    rs724882621,2
    C,F--21421915(+) CATTAT/CAAATA 1 -- us2k11Minor allele frequency- C:0.09EA 120
    rs1428189571,2
    --21421921(+) AAATAA/GCACTG 1 -- us2k10--------
    rs27713561,2
    C,A,H--21421957(+) AGCCAA/GGTACC 1 -- us2k1 tfbs310Minor allele frequency- G:0.00NA WA CSA 17
    rs1878474111,2
    --21421961(+) AGGTAC/TCTGCC 1 -- us2k10--------
    rs1924746451,2
    --21422056(+) AGAGCA/GGATAC 1 -- us2k10--------
    rs1839887811,2
    --21422181(+) AGGACG/TTCAAG 1 -- us2k10--------
    rs1177753461,2
    F--21422206(+) GCTGCG/TCATTG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1421917801,2
    --21422221(+) CTCACC/TGGGTC 1 -- us2k10--------
    rs1878617511,2
    --21422233(+) CCATTG/TTGTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNASE2 (21423611 - 21424595 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RNASE2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1206CNV Insertion18451855
    nsv456146CNV Loss19166990
    nsv470622CNV Loss18288195
    nsv826880CNV Gain20364138
    nsv826881CNV Gain20364138
    nsv832740CNV Gain17160897
    nsv527381CNV Gain19592680
    nsv428293CNV Gain+Loss18775914
    nsv9121CNV Gain+Loss18304495
    essv941CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing RNASE2
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 131410    OMIM disorders: --

    5 diseases from the University of Copenhagen DISEASES database for RNASE2:
    Eosinophilia     Asthma     Eosinophilic esophagitis     Allergic rhinitis
    Migraine

    Find genes that share disorders with RNASE2           About GenesLikeMe

    4 Novoseek inferred disease relationships for RNASE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 39.4 3 7616105 (1), 8999843 (1)
    bronchoalveolar lavage fluid 22.4 1 15356558 (1)
    asthma 0 5 15356558 (3)
    inflammation 0 2 9620664 (1), 7851097 (1)

    Genetic Association Database (GAD): RNASE2
    Human Genome Epidemiology (HuGE) Navigator: RNASE2 (3 documents)

    Export disorders for RNASE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RNASE2 gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with RNASE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family. (PubMed id 2734298)1, 2, 3 Rosenberg H.F.... Ackerman S.J. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    2. Characterization of a unique nonsecretory ribonuclease from urine of pregnant women. (PubMed id 1587793)1, 2, 9 Sakakibara R.... Ishiguro M. (J. Biochem. 1992)
    3. Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp. (PubMed id 9450956)1, 2, 9 Krieg J....Hofsteenge J. (Mol. Biol. Cell 1998)
    4. Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations. (PubMed id 18636464)1, 4, 9 Ueki M....Yasuda T. (Cell Biochem. Funct. 2008)
    5. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. (PubMed id 1577491)1, 3, 9 Mastrianni D.M.... Ackerman S.J. (Genomics 1992)
    6. Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. (PubMed id 15755456)1, 2, 9 Iyer S.... Acharya K.R. (J. Mol. Biol. 2005)
    7. Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2). (PubMed id 12578357)1, 2, 9 Teufel D.P.... Shapiro R. (Biochemistry 2003)
    8. Sequence variation at two eosinophil-associated ribonuclease loci in humans. (PubMed id 11102386)1, 2, 9 Zhang J. and Rosenberg H.F. (Genetics 2000)
    9. Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. (PubMed id 2387583)1, 2, 9 Hamann K.J.... Barker R.L. (Genomics 1990)
    10. Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. (PubMed id 12855582)1, 2, 9 Yang D....Oppenheim J.J. (Blood 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6036 HGNC: 10045 AceView: RNASE2 Ensembl:ENSG00000169385 euGenes: HUgn6036
    ECgene: RNASE2 H-InvDB: RNASE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RNASE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RNASE2 gene:
    Search GeneIP for patents involving RNASE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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