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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE2 Gene

protein-coding   GIFtS: 54
GCID: GC14P021423

ribonuclease, RNase A family, 2 (liver, eosinophil-derived...


(Previous symbol: RNS2)
 Explore 28 diseases affiliated with
RNASE2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNASE2    

Aliases
for RNASE2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin)1 2     Ribonuclease US2 3
EDN1 2 3 5     RNase 22 3
RNS21 2 3 5     RNase UpI-22 3
Eosinophil-Derived Neurotoxin2 3     EC 3.1.27.53 8
Ribonuclease 22 3     Non-Secretory Ribonuclease2

External Ids:    HGNC: 100451   Entrez Gene: 60362   Ensembl: ENSG000001693857   OMIM: 1314105   UniProtKB: P101533   

Export aliases for RNASE2 gene to outside databases

Previous GC identifers: GC14P018796 GC14P015210 GC14P019413 GC14P020493 GC14P001544


Summaries
for RNASE2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153
Function: This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U.
Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological
activities

Gene Wiki entry for RNASE2 (Eosinophil-derived neurotoxin)


Genomic Views
for RNASE2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE2 gene promoter:
         C/EBPbeta   MyoD   Lmo2   C/EBPalpha   NF-AT   Evi-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASE2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASE2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24-q31   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q24-q31

RNASE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021423:  view genomic region     (about GC identifiers)

Start:
 21,423,611 bp from pter      End:
 21,424,595 bp from pter
Size:
 985 bases      Orientation:
 plus strand

Proteins
for RNASE2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153 (See protein sequence)
Recommended Name: Non-secretory ribonuclease precursor  
Size: 161 amino acids; 18354 Da
Subunit: Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur
Subcellular location: Lysosome (Probable). Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule
6/11 PDB 3D structures from and Proteopedia for RNASE2 (see all 11):
1GQV (3D)        1HI2 (3D)        1HI3 (3D)        1HI4 (3D)        1HI5 (3D)        1K2A (3D)    
Secondary accessions: Q52M39 Q9H2B7 Q9UCG7

Explore the universe of human proteins at neXtProt for RNASE2: NX_P10153

Post-translational modifications:

  • A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in
    • pregnant women urine, from other nonsecretory RNases1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P10153

    • 4/8 DME Specific Peptides for RNASE2 (P10153) (see all 8)
     VACDNRD  QHINMTS  VVNVCGN  YPVVPVHLD 

    RNASE2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002925.1  
    ENSEMBL proteins: 
     ENSP00000303276  

    Human Recombinant Protein Products: 
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    Novus Biologicals RNASE2 Proteins
    Novus Biologicals RNASE2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RNASE2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS2734298
    GO:0005764lysosome IEA--


    RNASE2 for ontologies           About GeneDecksing



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    Assay Products for RNASE2: 
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    Uscn ELISAs and CLIAs for RNASE2

    Protein Domains /
    Families
    for RNASE2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNASE2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P10153

    ProtoNet protein and cluster: P10153

    1 Blocks protein family: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153
    Domain: The N-terminal region is necessary for mediating chemotactic activity
    Similarity: Belongs to the pancreatic ribonuclease family


    Function
    for RNASE2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153
    Function: This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U.
    Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological
    activities
    Catalytic activity: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or
    Up with 2',3'-cyclic phosphate intermediates

         Genatlas biochemistry entry for RNASE2:
    ribonuclease RNAse A family,2,eosinophil-derived neurotoxin

    Enzyme Number (IUBMB): EC 3.1.27.51 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RNASE2
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    SwitchGear 3'UTR luciferase reporter plasmid: RNASE2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE2 (see all 4)
    OriGene shRNA RFP: RNASE2
    OriGene siRNA: RNASE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RNASE2

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE2 

    Cell Line
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    Search LifeMap BioReagents cell lines for RNASE2

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RNASE2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0004540ribonuclease activity TAS2734298


    RNASE2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for RNASE2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RNASE2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RNASE2 (P101533 ENSP000003032764) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCE1P612213, ENSP000002965774I2D: score=2 STRING: ENSP00000296577
    RNH1P134893, ENSP000003464024I2D: score=2 STRING: ENSP00000346402
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006401RNA catabolic process TAS2734298
    GO:0006935chemotaxis IDA12855582


    RNASE2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for RNASE2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNASE2 for compounds           About GeneDecksing

    EMD Millipore small molecules for RNASE2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASE2

    3 DrugBank Compounds for RNASE2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-2'-5'-Diphosphate-- --target--17139284 17016423
    Adenosine-3'-5'-Diphosphate-- --target--17139284 17016423
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423

    1 Novoseek chemical compound relationship for RNASE2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    butyrate 38.2 3 7616105 (1), 19279013 (1)

    Search CenterWatch for drugs/clinical trials and news about RNASE2 / RNAS2 

    Transcripts
    for RNASE2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNASE2 gene: 
    NM_002934.2  

    Unigene Cluster for RNASE2:

    Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
    Hs.728  [show with all ESTs]
    Unigene Representative Sequence: NM_002934
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304625(uc010aif.2 uc001vyl.1)

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: RNASE2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE2 (see all 4)
    OriGene shRNA RFP: RNASE2
    OriGene siRNA: RNASE2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE2
    Clone
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    GenScript: all cDNA clones in your preferred vector: RNASE2 (NM_002934)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASE2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE2

    Additional cDNA sequence: 

    BC093678.1 BC093680.1 BC096059.3 BC143324.1 M24157.1 M28129.1 M30510.1 X55988.1 

    2 DOTS entries:

    DT.211183  DT.120782824 

    24/34 AceView cDNA sequences (see all 34):

    BX279624 BF895386 M24157 NM_002934 AJ713186 M28129 BF895383 BF892299 
    BI018358 X55988 BF905649 M30510 AA746216 AA984940 BF904799 BF905650 
    BF935781 T86316 BF892545 BF894574 BF894582 BF902237 AV714039 BF895432 

    GeneLoc Exon Structure


    Expression
    for RNASE2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGACAACAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RNASE2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleCumulus CellsOvary
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RNASE2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNASE2

    SOURCE GeneReport for Unigene cluster: Hs.728

    UniProtKB/Swiss-Prot: RNAS2_HUMAN, P10153
    Tissue specificity: Liver, lung, spleen, leukocytes and body fluids

        SABiosciences Expression via Pathway-Focused PCR Array including RNASE2: 
              Allergy & Asthma in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RNASE2

    Orthologs
    for RNASE2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RSFR_CHICK6
    RNL2_CHICK6
    		 Ribonuclease CL2
    		 23(a)
    21(a)
    		 many ↔ many
    many ↔ many
    		 6(10376970-10386988)
    4(51109366-51110407)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 22(a)
    22(a)
    (see all 3)    		 many ↔ many
    possible ortholog
    (see all 3)    		 GL343220.1(1531632-1532063)
    GL343220.1(1438299-1438661)
    zebrafish
    (Danio rerio)    		 Actinopterygii rnasel36
    rnasel26
    		 ribonuclease like 2
    		 22(a)
    21(a)
    		 many ↔ many
    many ↔ many
    		 14(40044381-40046544)
    22(6217650-6218836)


    ENSEMBL Gene Tree for RNASE2 (if available)
    TreeFam Gene Tree for RNASE2 (if available) 

    Paralogs
    for RNASE2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNASE2 gene
    RNASE32  RNASE72  RNASE82  ANG2  RNASE62  RNASE42  RNASE12  ENSG000002588182  
    5 SIMAP similar genes for RNASE2 using alignment to 1 protein entry:     RNAS2_HUMAN:
    ECRP    RNASE3    RNASE8    RNASE6    RNASE7

    RNASE2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RNASE2
    PGOHUM00000261850


    Genomic Variants
    for RNASE2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/96 NCBI SNPs in RNASE2 are shown (see all 96)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1823457901,2
    		--21421643(+) GTCTGA/CTGCGT 1 -- us2k10--------
    rs724882621,2
    		F,--21421915(+) CATTAT/CAAATA 1 -- us2k11Minor allele frequency- C:0.09EA 120
    rs1428189571,2
    		--21421921(+) AAATAA/GCACTG 1 -- us2k10--------
    rs27713561,2
    		C,A,H,--21421957(+) AGCCAA/GGTACC 1 -- us2k1 tfbs310Minor allele frequency- G:0.00NA WA CSA 17
    rs1878474111,2
    		--21421961(+) AGGTAC/TCTGCC 1 -- us2k10--------
    rs1924746451,2
    		--21422056(+) AGAGCA/GGATAC 1 -- us2k10--------
    rs1839887811,2
    		--21422181(+) AGGACG/TTCAAG 1 -- us2k10--------
    rs1177753461,2
    		--21422206(+) GCTGCG/TCATTG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1421917801,2
    		--21422221(+) CTCACC/TGGGTC 1 -- us2k10--------
    rs1878617511,2
    		--21422233(+) CCATTG/TTGTCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RNASE2 (21423611 - 21424595 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for RNASE2
         5 CNVs: 87132 76575 3037 3930 30651

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE2
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE2

    Disorders / Diseases
    for RNASE2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNASE2 for disorders           About GeneDecksing

    OMIM gene information: 131410    OMIM disorders: --

    20/28 diseases for RNASE2 (see all 28):    About MalaCards
    specific phobia    nijmegen breakage syndrome    paragonimiasis    eosinophilic esophagitis
    allergic rhinitis    pulmonary eosinophilia    atopic dermatitis    ascariasis
    onchocerciasis    phobia    trichuriasis    eosinophilia
    allergic asthma    rhinitis    diabetic neuropathy    asthma
    rheumatoid arthritis    dermatitis    neuropathy    atopy

    5 diseases from the University of Copenhagen DISEASES database for RNASE2:
    Eosinophilia     Asthma     Eosinophilic esophagitis     Migraine
    Allergic rhinitis

    4 Novoseek disease relationships for RNASE2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 39.4 3 7616105 (1), 8999843 (1)
    bronchoalveolar lavage fluid 22.4 1 15356558 (1)
    asthma 0 5 15356558 (3)
    inflammation 0 2 9620664 (1), 7851097 (1)

    Genetic Association Database (GAD): RNASE2
    Human Genome Epidemiology (HuGE) Navigator: RNASE2 (3 documents)

    Export disorders for RNASE2 gene to outside databases

    Publications
    for RNASE2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASE2 gene, integrated from 9 sources (see all 93):
    (articles sorted by number of sources associating them with RNASE2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family. (PubMed id 2734298)1, 2, 3 Rosenberg H.F.... Ackerman S.J. (1989)
    2. Characterization of a unique nonsecretory ribonuclease from urine of pregnant women. (PubMed id 1587793)1, 2, 9 Sakakibara R.... Ishiguro M. (1992)
    3. Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp. (PubMed id 9450956)1, 2, 9 Krieg J....Hofsteenge J. (1998)
    4. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. (PubMed id 1577491)1, 3, 9 Mastrianni D.M.... Ackerman S.J. (1992)
    5. Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. (PubMed id 15755456)1, 2, 9 Iyer S....Acharya K.R. (2005)
    6. Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2). (PubMed id 12578357)1, 2, 9 Teufel D.P....Shapiro R. (2003)
    7. Sequence variation at two eosinophil-associated ribonuclease loci in humans. (PubMed id 11102386)1, 2, 9 Zhang J. and Rosenberg H.F. (2000)
    8. Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily. (PubMed id 2387583)1, 2, 9 Hamann K.J.... Barker R.L. (1990)
    9. Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. (PubMed id 12855582)1, 2, 9 Yang D....Oppenheim J.J. (2003)
    10. Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia. (PubMed id 16014847)1, 4 Kim Y.J....Nutman T.B. (2005)

    External Searches for RNASE2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing RNASE2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6036 HGNC: 10045 AceView: RNASE2 Ensembl:ENSG00000169385 euGenes: HUgn6036
    ECgene: RNASE2 H-InvDB: RNASE2

    Other Databases showing RNASE2 gene

    (According to HUGE)
    About This Section
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    Specialized Databases showing RNASE2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNASE2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNASE2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNASE2 gene:
    Search GeneIP for patents involving RNASE2

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