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Aliases for RNASE2 Gene

Aliases for RNASE2 Gene

  • Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin) 2 3
  • Eosinophil-Derived Neurotoxin 3 4
  • Ribonuclease US 3 4
  • Ribonuclease 2 3 4
  • RNase UpI-2 3 4
  • EC 3.1.27.5 4 63
  • RNase 2 3 4
  • RNS2 3 4
  • EDN 3 4
  • Ribonuclease A F3 3
  • RAF3 3

External Ids for RNASE2 Gene

Previous HGNC Symbols for RNASE2 Gene

  • RNS2

Previous GeneCards Identifiers for RNASE2 Gene

  • GC14P018796
  • GC14P015210
  • GC14P019413
  • GC14P020493
  • GC14P021423
  • GC14P001544
  • GC14P021026

Summaries for RNASE2 Gene

Entrez Gene Summary for RNASE2 Gene

  • The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE2 Gene

RNASE2 (Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE2 Gene

  • This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.

Gene Wiki entry for RNASE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE2 Gene

Genomics for RNASE2 Gene

Regulatory Elements for RNASE2 Gene

Genomic Location for RNASE2 Gene

Chromosome:
14
Start:
20,955,452 bp from pter
End:
20,956,436 bp from pter
Size:
985 bases
Orientation:
Plus strand

Genomic View for RNASE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE2 Gene

Proteins for RNASE2 Gene

  • Protein details for RNASE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10153-RNAS2_HUMAN
    Recommended name:
    Non-secretory ribonuclease
    Protein Accession:
    P10153
    Secondary Accessions:
    • Q52M39
    • Q9H2B7
    • Q9UCG7

    Protein attributes for RNASE2 Gene

    Size:
    161 amino acids
    Molecular mass:
    18354 Da
    Quaternary structure:
    • Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.

    Three dimensional structures from OCA and Proteopedia for RNASE2 Gene

neXtProt entry for RNASE2 Gene

Proteomics data for RNASE2 Gene at MOPED

Selected DME Specific Peptides for RNASE2 Gene

Post-translational modifications for RNASE2 Gene

  • A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in pregnant women urine, from other nonsecretory RNases.
  • Glycosylation at Trp 34, Asn 44, Asn 86, Asn 92, Asn 111, and Asn 119
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for RNASE2 Gene

Gene Families for RNASE2 Gene

Protein Domains for RNASE2 Gene

Suggested Antigen Peptide Sequences for RNASE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10153

UniProtKB/Swiss-Prot:

RNAS2_HUMAN :
  • The N-terminal region is necessary for mediating chemotactic activity
  • Belongs to the pancreatic ribonuclease family.
Domain:
  • The N-terminal region is necessary for mediating chemotactic activity
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE2: view

Function for RNASE2 Gene

Molecular function for RNASE2 Gene

GENATLAS Biochemistry:
ribonuclease RNAse A family,2,eosinophil-derived neurotoxin
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to nucleoside 3-phosphates and 3-phosphooligonucleotides ending in Cp or Up with 2,3-cyclic phosphate intermediates
UniProtKB/Swiss-Prot Function:
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.

Enzyme Numbers (IUBMB) for RNASE2 Gene

Gene Ontology (GO) - Molecular Function for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004522 ribonuclease A activity IEA --
GO:0004540 ribonuclease activity TAS 2734298
genes like me logo Genes that share ontologies with RNASE2: view

Phenotypes for RNASE2 Gene

genes like me logo Genes that share phenotypes with RNASE2: view

Animal Model Products

CRISPR Products

miRNA for RNASE2 Gene

miRTarBase miRNAs that target RNASE2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE2 Gene

Localization for RNASE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE2 Gene

Lysosome. Cytoplasmic granule. Note=Matrix of eosinophils large specific granule.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE2 Gene COMPARTMENTS Subcellular localization image for RNASE2 gene
Compartment Confidence
extracellular 5
lysosome 3
vacuole 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS 2734298
GO:0005764 lysosome IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE2: view

Pathways & Interactions for RNASE2 Gene

SuperPathways for RNASE2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for RNASE2 Gene

Gene Ontology (GO) - Biological Process for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process TAS 2734298
GO:0006935 chemotaxis IDA 12855582
GO:0090305 nucleic acid phosphodiester bond hydrolysis IBA --
GO:0090501 RNA phosphodiester bond hydrolysis TAS 2734298
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASE2: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE2 Gene

Drugs & Compounds for RNASE2 Gene

(2) Drugs for RNASE2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine-2'-5'-Diphosphate Experimental Pharma Target 0
Adenosine-3'-5'-Diphosphate Experimental Pharma Target 0

(1) Additional Compounds for RNASE2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
butyrate
genes like me logo Genes that share compounds with RNASE2: view

Transcripts for RNASE2 Gene

mRNA/cDNA for RNASE2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE2 Gene

Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE2 Gene

No ASD Table

Relevant External Links for RNASE2 Gene

GeneLoc Exon Structure for
RNASE2
ECgene alternative splicing isoforms for
RNASE2

Expression for RNASE2 Gene

mRNA expression in normal human tissues for RNASE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE2 Gene

This gene is overexpressed in Whole Blood (x42.0).

Protein differential expression in normal tissues from HIPED for RNASE2 Gene

This gene is overexpressed in Urine (34.2), Spleen (7.7), and Neutrophil (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE2 Gene



SOURCE GeneReport for Unigene cluster for RNASE2 Gene Hs.728

mRNA Expression by UniProt/SwissProt for RNASE2 Gene

P10153-RNAS2_HUMAN
Tissue specificity: Liver, lung, spleen, leukocytes and body fluids
genes like me logo Genes that share expression patterns with RNASE2: view

Protein tissue co-expression partners for RNASE2 Gene

Primer Products

In Situ Assay Products

Orthologs for RNASE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASE3 35
  • 65.82 (n)
  • 55.7 (a)
-- 36
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ear11 35
  • 64.57 (n)
  • 51.18 (a)
Ear11 16
Ear1 36
  • 50 (a)
ManyToMany
Ear10 36
  • 49 (a)
ManyToMany
Ear11 36
  • 48 (a)
ManyToMany
Ear14 36
  • 50 (a)
ManyToMany
Ear2 36
  • 48 (a)
ManyToMany
Ear5 36
  • 50 (a)
ManyToMany
Ear6 36
  • 51 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia RNASE2 35
  • 98.96 (n)
  • 98.76 (a)
RNASE2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 34 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ANG 36
  • 25 (a)
ManyToMany
CL2 36
  • 18 (a)
ManyToMany
RSFR 36
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
Species with no ortholog for RNASE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE2 Gene

ENSEMBL:
Gene Tree for RNASE2 (if available)
TreeFam:
Gene Tree for RNASE2 (if available)

Paralogs for RNASE2 Gene

Paralogs for RNASE2 Gene

(5) SIMAP similar genes for RNASE2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RNASE2 Gene

genes like me logo Genes that share paralogs with RNASE2: view

Variants for RNASE2 Gene

Sequence variations from dbSNP and Humsavar for RNASE2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs945351 -- 20,955,528(-) GTCTC(A/C/T)GCGCT utr-variant-5-prime
rs2013109 -- 20,955,631(+) ACGTT(C/G)CACAC intron-variant
rs2771356 -- 20,953,798(+) AGCCA(A/G)GTACC upstream-variant-2KB
rs2771357 -- 20,954,096(+) AGGAC(C/T)CCAGT upstream-variant-2KB
rs2771358 -- 20,954,507(+) TTTCC(C/T)GTATG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE2 Gene

Variant ID Type Subtype PubMed ID
dgv607e1 CNV Complex 17122850
nsv428293 CNV Gain+Loss 18775914
dgv608e1 CNV Complex 17122850
nsv832740 CNV Gain 17160897
nsv470622 CNV Loss 18288195
nsv9121 CNV Gain+Loss 18304495
essv941 CNV CNV 17122850
nsv456146 CNV Loss 19166990
nsv1206 CNV Insertion 18451855
nsv826880 CNV Gain 20364138
nsv527381 CNV Gain 19592680
nsv514732 CNV Complex 21397061
nsv826881 CNV Gain 20364138

Variation tolerance for RNASE2 Gene

Residual Variation Intolerance Score: 80.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE2 Gene

HapMap Linkage Disequilibrium report
RNASE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE2 Gene

Disorders for RNASE2 Gene

Relevant External Links for RNASE2

Genetic Association Database (GAD)
RNASE2
Human Genome Epidemiology (HuGE) Navigator
RNASE2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE2
genes like me logo Genes that share disorders with RNASE2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE2 Gene

Publications for RNASE2 Gene

  1. Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14. (PMID: 1577491) Mastrianni D.M. … Ackerman S.J. (Genomics 1992) 2 23 67
  2. Eosinophil ribonucleases and their cutaneous lesion-forming activity. (PMID: 19717523) Plager D.A. … Leiferman K.M. (J. Immunol. 2009) 23 67
  3. GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) gene. (PMID: 19279013) Qiu Z. … Rosenberg H.F. (J. Biol. Chem. 2009) 23 67
  4. Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations. (PMID: 18636464) Ueki M. … Yasuda T. (Cell Biochem. Funct. 2008) 23 67
  5. Eosinophil-derived neurotoxin / RNase 2: connecting the past, the present and the future. (PMID: 18673278) Rosenberg H.F. (Curr Pharm Biotechnol 2008) 23 67

Products for RNASE2 Gene

Sources for RNASE2 Gene

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