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Aliases for RNASE13 Gene

Aliases for RNASE13 Gene

  • Ribonuclease A Family Member 13 (Inactive) 2 3 5
  • Ribonuclease, RNase A Family, 13 (Non-Active) 2 3
  • Epididymis Secretory Sperm Binding Protein Li 86p 3
  • Probable Inactive Ribonuclease-Like Protein 13 3
  • Ribonuclease-Like Protein 13 3
  • Ribonuclease A L1 3
  • Ribonuclease 13 3
  • HEL-S-86p 3
  • RAL1 3

External Ids for RNASE13 Gene

Previous GeneCards Identifiers for RNASE13 Gene

  • GC14M020571
  • GC14M021500
  • GC14M001621

Summaries for RNASE13 Gene

GeneCards Summary for RNASE13 Gene

RNASE13 (Ribonuclease A Family Member 13 (Inactive)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity.

UniProtKB/Swiss-Prot for RNASE13 Gene

  • Does not exhibit any ribonuclease activity.

Additional gene information for RNASE13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE13 Gene

Genomics for RNASE13 Gene

Regulatory Elements for RNASE13 Gene

Enhancers for RNASE13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H021191 1.1 Ensembl ENCODE 9.9 -157.3 -157316 1 ZFP64 RAD21 GLIS2 ZNF362 SP3 SP5 ZEB2 KAT8 KLF16 ZSCAN16 OR5AU1 ZNF219 TMEM253 ENSG00000255472 RNASE13 TPPP2 LOC100129923 LINC00641
GH14H020997 1 Ensembl ENCODE 10.8 +36.1 36100 2 SCRT1 STAT1 SP3 SMARCC1 SP2 KLF17 ZIC2 POLR2A ZNF629 SCRT2 SLC39A2 TPPP2 ENSG00000255472 RNASE13 ZNF219 TMEM253 RNASE7 LOC101929718 METTL17
GH14H020705 0.8 Ensembl ENCODE 9.6 +327.7 327654 2 SREBF1 ZNF217 SMARCE1 CTBP1 ZNF766 SOX6 TEAD3 EDDM3A ANG EDDM3B RNASE1 METTL17 ZNF219 TPPP2 ENSG00000255472 RNASE13 RNA5SP382
GH14H020591 0.4 FANTOM5 7.2 +442.9 442914 0 IKZF1 OR4K17 OR6S1 RNASE12 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASE13 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE13 Gene

21,032,820 bp from pter
21,034,785 bp from pter
1,966 bases
Minus strand

Genomic View for RNASE13 Gene

Genes around RNASE13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE13 Gene

Proteins for RNASE13 Gene

  • Protein details for RNASE13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable inactive ribonuclease-like protein 13
    Protein Accession:

    Protein attributes for RNASE13 Gene

    156 amino acids
    Molecular mass:
    17845 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE13 Gene

Post-translational modifications for RNASE13 Gene

  • Glycosylation at Asn126
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE13 Gene

Domains & Families for RNASE13 Gene

Gene Families for RNASE13 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE13 Gene

Suggested Antigen Peptide Sequences for RNASE13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE13: view

Function for RNASE13 Gene

Molecular function for RNASE13 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Gene Ontology (GO) - Molecular Function for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 NOT endonuclease activity IBA --
GO:0004540 NOT ribonuclease activity IKR 15676279
genes like me logo Genes that share ontologies with RNASE13: view

Phenotypes for RNASE13 Gene

GenomeRNAi human phenotypes for RNASE13:
genes like me logo Genes that share phenotypes with RNASE13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RNASE13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE13 Gene

Localization for RNASE13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE13 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE13 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE13 Gene

Pathways & Interactions for RNASE13 Gene

SuperPathways for RNASE13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNASE13 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNASE13 Gene

Drugs & Compounds for RNASE13 Gene

No Compound Related Data Available

Transcripts for RNASE13 Gene

mRNA/cDNA for RNASE13 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE13 Gene

Ribonuclease, RNase A family, 13 (non-active):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RNASE13
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE13 Gene

No ASD Table

Relevant External Links for RNASE13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE13 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE13 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE13 Gene:


SOURCE GeneReport for Unigene cluster for RNASE13 Gene:


Evidence on tissue expression from TISSUES for RNASE13 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with RNASE13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE13 Gene

Orthologs for RNASE13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE13 33 34
  • 99.36 (n)
(Canis familiaris)
Mammalia RNASE13 33 34
  • 78.43 (n)
(Bos Taurus)
Mammalia RNASE13 33 34
  • 78 (n)
(Mus musculus)
Mammalia Rnase13 33 16 34
  • 77.56 (n)
(Rattus norvegicus)
Mammalia Rnase13 33
  • 75.6 (n)
(Monodelphis domestica)
Mammalia RNASE13 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia RNASE13 34
  • 39 (a)
Species where no ortholog for RNASE13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE13 Gene

Gene Tree for RNASE13 (if available)
Gene Tree for RNASE13 (if available)

Paralogs for RNASE13 Gene

No data available for Paralogs for RNASE13 Gene

Variants for RNASE13 Gene

Sequence variations from dbSNP and Humsavar for RNASE13 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000119394 -- 21,032,810(+) CAACA(A/G)AGTCA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1002122201 -- 21,035,193(+) CTTAC(C/T)CCTGT intron-variant, upstream-variant-2KB
rs1002168055 -- 21,034,465(+) GACAA(-/CCAG)CCAGC intron-variant
rs1004138491 -- 21,036,382(+) GAAGA(A/G)TTGTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1004348905 -- 21,032,450(+) AAAGG(G/T)TGTAG intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNASE13 Gene

Variant ID Type Subtype PubMed ID
nsv1039369 CNV loss 25217958
nsv428293 CNV gain+loss 18775914
nsv832740 CNV gain 17160897

Variation tolerance for RNASE13 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE13 Gene

Disorders for RNASE13 Gene

Relevant External Links for RNASE13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RNASE13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE13 Gene

Publications for RNASE13 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S … Zhang J (Genomics 2005) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies. (PMID: 28339009) Yamada Y … Tanaka M (International journal of molecular medicine 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M (Molecular genetics and genomics : MGG 2014) 3 60

Products for RNASE13 Gene

Sources for RNASE13 Gene

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