RNASE13 Gene
protein-coding GIFtS: 36
GCID: GC14M021500
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ribonuclease, RNase A family, 13 (non-active)
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Aliases
for RNASE13 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribonuclease, RNase A Family, 13 (Non-Active)1 2 | | Probable Inactive Ribonuclease-Like Protein 132 | | Ribonuclease 132 | | Ribonuclease-Like Protein 132 |
Export aliases for RNASE13 gene to outside databasesPrevious GC identifers: GC14M020571 GC14M001621 |
Summaries
for RNASE13 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RNS13_HUMAN, Q5GAN3Function: Does not exhibit any ribonuclease activity (Potential)
|
Genomic Views
for RNASE13 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNASE13 gene promoter:
TBP Spz1 RP58 Nkx2-5 PPAR-alpha CREB PPAR-gamma1 c-Rel deltaCREB PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNASE13
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE13 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.1 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.1RNASE13 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M021500: view genomic region
(about GC identifiers)
Start:
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21,500,979 bp from pter |
End:
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21,502,944 bp from pter |
Size:
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1,966 bases |
Orientation:
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minus strand |
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Proteins
for RNASE13 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNS13_HUMAN, Q5GAN3 (See
protein sequence)Recommended Name: Probable inactive ribonuclease-like protein 13 precursor Size: 156 amino acids; 17845 Da
Subcellular location: Secreted (Probable)Explore the universe of human proteins at neXtProt for RNASE13: NX_Q5GAN3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5GAN3
RNASE13 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001012264.1
ENSEMBL proteins: ENSP00000372410
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
RNASE13 for ontologies About GeneDecksing
RNASE13 Antibody Products:
Assay Products for RNASE13: |
Protein
Domains /
Families
for RNASE13 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNASE13 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5GAN3ProtoNet protein and cluster: Q5GAN3 UniProtKB/Swiss-Prot: RNS13_HUMAN, Q5GAN3Similarity: Belongs to the pancreatic ribonuclease family |
Function
for RNASE13 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RNS13_HUMAN, Q5GAN3Function: Does not exhibit any ribonuclease activity (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNASE13 (NM_001012264) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE13 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE13 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE13 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0004522 | pancreatic ribonuclease activity |
IEA | -- |
RNASE13 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNASE13 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE13
|
Drugs & Compounds
for RNASE13 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNASE13
Search CenterWatch for drugs/clinical trials and news about RNASE13 / RNS13
|
Transcripts
for RNASE13 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNASE13 gene: NM_001012264.3 Unigene Cluster for RNASE13: Ribonuclease, RNase A family, 13 (non-active) Hs.666729 [show with all ESTs]Unigene Representative Sequence: BC0448311 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000382951(uc001vzj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE13 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE13
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNASE13 (NM_001012264) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE13 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE13 |
Additional cDNA sequence: AY665808.1 BC044831.1 1 DOTS entry: DT.95243562 3 AceView cDNA sequences: BC044831 AI027773 BI828869
GeneLoc Exon Structure
|
Expression
for RNASE13 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNASE13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RNASE13 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.666729
SABiosciences Custom PCR Arrays for RNASE13
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE13
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASE13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE13 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE13 |
Orthologs
for RNASE13 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for RNASE13 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for RNASE13 (if available)
TreeFam Gene Tree for RNASE13 (if available) |
Paralogs
for RNASE13 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RNASE13 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNASE13 (21500979 - 21502944 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RNASE13: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE13 |
|
Disorders
/ Diseases
for RNASE13 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNASE13 for disorders About GeneDecksing
1  disease for RNASE13: About MalaCardspancreatitis
Export disorders for RNASE13 gene to outside databases
|
Publications
for RNASE13 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNASE13 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNASE13) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1, 2 Cho S.... Zhang J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RNASE13 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RNASE13 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNASE13 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNASE13 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNASE13 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNASE13 gene:
Search GeneIP for patents involving RNASE13
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNASE13 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNASE13 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE13 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE13 | | | OriGene Protein Over-expression Lysate for RNASE13 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNASE13 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE13 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE13 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNASE13 | | OriGene Custom Protein Services for RNASE13 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASE13 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE13 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE13 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE13 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE13 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE13 |
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 |  |  |  | |
| | | | Search Tocris compounds for RNASE13 |
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 | | | RNASE13 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE13 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNASE13 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE13 |
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