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Aliases for RNASE13 Gene

Aliases for RNASE13 Gene

  • Ribonuclease A Family Member 13 (Inactive) 2 3 5
  • Ribonuclease, RNase A Family, 13 (Non-Active) 2 3
  • Epididymis Secretory Sperm Binding Protein Li 86p 3
  • Probable Inactive Ribonuclease-Like Protein 13 3
  • Ribonuclease-Like Protein 13 3
  • Ribonuclease A L1 3
  • Ribonuclease 13 3
  • HEL-S-86p 3
  • RAL1 3

External Ids for RNASE13 Gene

Previous GeneCards Identifiers for RNASE13 Gene

  • GC14M020571
  • GC14M021500
  • GC14M001621

Summaries for RNASE13 Gene

GeneCards Summary for RNASE13 Gene

RNASE13 (Ribonuclease A Family Member 13 (Inactive)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity.

UniProtKB/Swiss-Prot for RNASE13 Gene

  • Does not exhibit any ribonuclease activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE13 Gene

Genomics for RNASE13 Gene

Regulatory Elements for RNASE13 Gene

Enhancers for RNASE13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G021068 1.6 FANTOM5 ENCODE dbSUPER 10.4 -36.3 -36260 5.0 HDGF ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF143 FOS PAF1 ZNF263 ARHGEF40 SUPT16H METTL3 SALL2 TMEM253 ZNF219 RNASE7 TPPP2 ENSG00000255472 RNASE13
GH14G021191 1.1 Ensembl ENCODE 9.9 -157.3 -157316 1.4 ZFP64 RAD21 ZNF48 GLIS2 PCBP1 SP3 ZNF362 SP5 ZHX2 ZEB2 OR5AU1 ZNF219 TMEM253 ENSG00000255472 RNASE13 TPPP2 LOC100129923 LINC00641
GH14G020997 1 Ensembl ENCODE 10.8 +36.1 36100 2.9 KLF17 ZIC2 SCRT2 ZNF600 PRDM10 FOS KLF8 SCRT1 SMARCC1 SP3 SLC39A2 TPPP2 ENSG00000255472 RNASE13 ZNF219 TMEM253 RNASE7 LOC101929718 METTL17
GH14G020705 0.9 Ensembl ENCODE 9.6 +327.7 327654 2.6 SREBF1 CTBP1 ZNF766 RAD51 GATA2 ZHX2 FOS TEAD3 EDDM3A ANG EDDM3B RNASE1 METTL17 ZNF219 TPPP2 ENSG00000255472 RNASE13 RNA5SP382
GH14G020591 0.6 FANTOM5 7.2 +442.9 442914 0.1 ZFHX2 IKZF1 TRIM22 IRF1 EGR2 OR4K17 OR6S1 RNASE12 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASE13 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE13 Gene

Chromosome:
14
Start:
21,032,820 bp from pter
End:
21,034,785 bp from pter
Size:
1,966 bases
Orientation:
Minus strand

Genomic View for RNASE13 Gene

Genes around RNASE13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE13 Gene

Proteins for RNASE13 Gene

  • Protein details for RNASE13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GAN3-RNS13_HUMAN
    Recommended name:
    Probable inactive ribonuclease-like protein 13
    Protein Accession:
    Q5GAN3

    Protein attributes for RNASE13 Gene

    Size:
    156 amino acids
    Molecular mass:
    17845 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE13 Gene

Post-translational modifications for RNASE13 Gene

  • Glycosylation at isoforms=126
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE13 Gene

Domains & Families for RNASE13 Gene

Gene Families for RNASE13 Gene

Protein Domains for RNASE13 Gene

Suggested Antigen Peptide Sequences for RNASE13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GAN3

UniProtKB/Swiss-Prot:

RNS13_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE13: view

Function for RNASE13 Gene

Molecular function for RNASE13 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Gene Ontology (GO) - Molecular Function for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 NOT endonuclease activity IBA --
GO:0004540 NOT ribonuclease activity IKR 15676279
genes like me logo Genes that share ontologies with RNASE13: view

Phenotypes for RNASE13 Gene

GenomeRNAi human phenotypes for RNASE13:
genes like me logo Genes that share phenotypes with RNASE13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE13 Gene

Localization for RNASE13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE13 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE13: view

Pathways & Interactions for RNASE13 Gene

SuperPathways for RNASE13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNASE13 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNASE13 Gene

Drugs & Compounds for RNASE13 Gene

No Compound Related Data Available

Transcripts for RNASE13 Gene

mRNA/cDNA for RNASE13 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE13 Gene

Ribonuclease, RNase A family, 13 (non-active):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE13 Gene

No ASD Table

Relevant External Links for RNASE13 Gene

GeneLoc Exon Structure for
RNASE13
ECgene alternative splicing isoforms for
RNASE13

Expression for RNASE13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE13 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE13 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNASE13 Gene:

RNASE13

SOURCE GeneReport for Unigene cluster for RNASE13 Gene:

Hs.666729

Evidence on tissue expression from TISSUES for RNASE13 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with RNASE13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE13 Gene

Orthologs for RNASE13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE13 34 35
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia RNASE13 35 34
  • 78.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNASE13 34 35
  • 78 (n)
mouse
(Mus musculus)
Mammalia Rnase13 34 16 35
  • 77.56 (n)
rat
(Rattus norvegicus)
Mammalia Rnase13 34
  • 75.6 (n)
oppossum
(Monodelphis domestica)
Mammalia RNASE13 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNASE13 35
  • 39 (a)
OneToOne
Species where no ortholog for RNASE13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE13 Gene

ENSEMBL:
Gene Tree for RNASE13 (if available)
TreeFam:
Gene Tree for RNASE13 (if available)

Paralogs for RNASE13 Gene

No data available for Paralogs for RNASE13 Gene

Variants for RNASE13 Gene

Sequence variations from dbSNP and Humsavar for RNASE13 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000119394 -- 21,032,810(+) CAACA(A/G)AGTCA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1002122201 -- 21,035,193(+) CTTAC(C/T)CCTGT intron-variant, upstream-variant-2KB
rs1002168055 -- 21,034,465(+) GACAA(-/CCAG)CCAGC intron-variant
rs1004138491 -- 21,036,382(+) GAAGA(A/G)TTGTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1004348905 -- 21,032,450(+) AAAGG(G/T)TGTAG intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNASE13 Gene

Variant ID Type Subtype PubMed ID
nsv1039369 CNV loss 25217958
nsv428293 CNV gain+loss 18775914
nsv832740 CNV gain 17160897

Variation tolerance for RNASE13 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE13 Gene

Disorders for RNASE13 Gene

Relevant External Links for RNASE13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE13

No disorders were found for RNASE13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE13 Gene

Publications for RNASE13 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for RNASE13 Gene

Sources for RNASE13 Gene

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