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Aliases for RNASE12 Gene

Aliases for RNASE12 Gene

  • Ribonuclease A Family Member 12 (Inactive) 2 3
  • Ribonuclease, RNase A Family, 12 (Non-Active) 2 3 5
  • Epididymis Secretory Sperm Binding Protein Li 85p 3
  • Ribonuclease-Like Protein 12 3
  • Ribonuclease A I1 3
  • HEL-S-85p 3
  • RAI1 3

External Ids for RNASE12 Gene

Previous GeneCards Identifiers for RNASE12 Gene

  • GC14U900487
  • GC14M020129
  • GC14M021058
  • GC14M001179

Summaries for RNASE12 Gene

GeneCards Summary for RNASE12 Gene

RNASE12 (Ribonuclease A Family Member 12 (Inactive)) is a Protein Coding gene. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is ENSG00000259060.

UniProtKB/Swiss-Prot for RNASE12 Gene

  • Does not exhibit any ribonuclease activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE12 Gene

Genomics for RNASE12 Gene

Regulatory Elements for RNASE12 Gene

Genomic Location for RNASE12 Gene

Chromosome:
14
Start:
20,590,080 bp from pter
End:
20,590,823 bp from pter
Size:
744 bases
Orientation:
Minus strand

Genomic View for RNASE12 Gene

Genes around RNASE12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE12 Gene

Proteins for RNASE12 Gene

  • Protein details for RNASE12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GAN4-RNS12_HUMAN
    Recommended name:
    Probable inactive ribonuclease-like protein 12
    Protein Accession:
    Q5GAN4

    Protein attributes for RNASE12 Gene

    Size:
    147 amino acids
    Molecular mass:
    17177 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE12 Gene

Proteomics data for RNASE12 Gene at MOPED

Post-translational modifications for RNASE12 Gene

No Post-translational modifications

Other Protein References for RNASE12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RNASE12 Gene

Domains & Families for RNASE12 Gene

Gene Families for RNASE12 Gene

Protein Domains for RNASE12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASE12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GAN4

UniProtKB/Swiss-Prot:

RNS12_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE12: view

Function for RNASE12 Gene

Molecular function for RNASE12 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Gene Ontology (GO) - Molecular Function for RNASE12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RNASE12: view

Phenotypes for RNASE12 Gene

genes like me logo Genes that share phenotypes with RNASE12: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE12 Gene

Localization for RNASE12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE12 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE12 Gene COMPARTMENTS Subcellular localization image for RNASE12 gene
Compartment Confidence
extracellular 3

No data available for Gene Ontology (GO) - Cellular Components for RNASE12 Gene

Pathways & Interactions for RNASE12 Gene

genes like me logo Genes that share pathways with RNASE12: view

Interacting Proteins for RNASE12 Gene

Gene Ontology (GO) - Biological Process for RNASE12 Gene

None

No data available for SIGNOR curated interactions for RNASE12 Gene

Drugs & Compounds for RNASE12 Gene

No Compound Related Data Available

Transcripts for RNASE12 Gene

mRNA/cDNA for RNASE12 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE12 Gene

Ribonuclease, RNase A family, 12 (non-active):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE12 Gene

No ASD Table

Relevant External Links for RNASE12 Gene

GeneLoc Exon Structure for
RNASE12
ECgene alternative splicing isoforms for
RNASE12

Expression for RNASE12 Gene

mRNA expression in normal human tissues for RNASE12 Gene

mRNA expression in normal human tissues for RNASE12 Gene

SOURCE GeneReport for Unigene cluster for RNASE12 Gene Hs.729466

genes like me logo Genes that share expression patterns with RNASE12: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNASE12 Gene

Orthologs for RNASE12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASE12 35
  • 82.76 (n)
  • 68.28 (a)
dog
(Canis familiaris)
Mammalia RNASE12 35
  • 79.54 (n)
  • 71.72 (a)
-- 36
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rnase12 35
  • 79.31 (n)
  • 68.28 (a)
Rnase12 16
Rnase12 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rnase12 35
  • 79.77 (n)
  • 71.03 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
Species with no ortholog for RNASE12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE12 Gene

ENSEMBL:
Gene Tree for RNASE12 (if available)
TreeFam:
Gene Tree for RNASE12 (if available)

Paralogs for RNASE12 Gene

Paralogs for RNASE12 Gene

(1) SIMAP similar genes for RNASE12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNASE12: view

Variants for RNASE12 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE12 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
nsv901468 CNV Gain 21882294
nsv901469 CNV Loss 21882294

Variation tolerance for RNASE12 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE12 Gene

HapMap Linkage Disequilibrium report
RNASE12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RNASE12 Gene

Disorders for RNASE12 Gene

Relevant External Links for RNASE12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE12

No disorders were found for RNASE12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE12 Gene

Publications for RNASE12 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 2 3 4 67
  2. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RNASE12 Gene

Sources for RNASE12 Gene

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