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Aliases for RNASE12 Gene

Aliases for RNASE12 Gene

  • Ribonuclease, RNase A Family, 12 (Non-Active) 2 3
  • Epididymis Secretory Sperm Binding Protein Li 85p 3
  • Probable Inactive Ribonuclease-Like Protein 12 3
  • Ribonuclease-Like Protein 12 3
  • Ribonuclease A I1 3
  • HEL-S-85p 3
  • RAI1 3

External Ids for RNASE12 Gene

Previous GeneCards Identifiers for RNASE12 Gene

  • GC14U900487
  • GC14M020129
  • GC14M021058
  • GC14M001179

Summaries for RNASE12 Gene

GeneCards Summary for RNASE12 Gene

RNASE12 (Ribonuclease, RNase A Family, 12 (Non-Active)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is RNASE11.

UniProtKB/Swiss-Prot for RNASE12 Gene

  • Does not exhibit any ribonuclease activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE12 Gene

Genomics for RNASE12 Gene

Regulatory Elements for RNASE12 Gene

Genomic Location for RNASE12 Gene

Start:
20,590,080 bp from pter
End:
20,590,823 bp from pter
Size:
744 bases
Orientation:
Minus strand

Genomic View for RNASE12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE12 Gene

Proteins for RNASE12 Gene

  • Protein details for RNASE12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GAN4-RNS12_HUMAN
    Recommended name:
    Probable inactive ribonuclease-like protein 12
    Protein Accession:
    Q5GAN4
    Secondary Accessions:

    Protein attributes for RNASE12 Gene

    Size:
    147 amino acids
    Molecular mass:
    17177 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE12 Gene

Proteomics data for RNASE12 Gene at MOPED

Post-translational modifications for RNASE12 Gene

No Post-translational modifications

Other Protein References for RNASE12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE12 Gene

Domains for RNASE12 Gene

Gene Families for RNASE12 Gene

HGNC:
  • RNASE :Ribonucleases, RNase A

Protein Domains for RNASE12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASE12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GAN4

UniProtKB/Swiss-Prot:

RNS12_HUMAN :
  • Q5GAN4
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE12: view

Function for RNASE12 Gene

Molecular function for RNASE12 Gene

UniProtKB/Swiss-Prot Function: Does not exhibit any ribonuclease activity.

Gene Ontology (GO) - Molecular Function for RNASE12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity IBA --
genes like me logo Genes that share ontologies with RNASE12: view

Animal Model Products

CRISPR Products

miRNA for RNASE12 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNASE12 Gene

Localization for RNASE12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE12 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE12 Gene COMPARTMENTS Subcellular localization image for RNASE12 gene
Compartment Confidence
extracellular 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RNASE12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE12: view

Pathways for RNASE12 Gene

SuperPathways for RNASE12 Gene

No Data Available

Interacting Proteins for RNASE12 Gene

Gene Ontology (GO) - Biological Process for RNASE12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IBA --
GO:0090501 RNA phosphodiester bond hydrolysis IBA --
genes like me logo Genes that share ontologies with RNASE12: view

No data available for Pathways by source for RNASE12 Gene

Transcripts for RNASE12 Gene

mRNA/cDNA for RNASE12 Gene

(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE12 Gene

Ribonuclease, RNase A family, 12 (non-active):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RNASE12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE12 Gene

No ASD Table

Relevant External Links for RNASE12 Gene

GeneLoc Exon Structure for
RNASE12
ECgene alternative splicing isoforms for
RNASE12

Expression for RNASE12 Gene

mRNA expression in normal human tissues for RNASE12 Gene

mRNA expression in normal human tissues for RNASE12 Gene

SOURCE GeneReport for Unigene cluster for RNASE12 Gene Hs.729466

genes like me logo Genes that share expressions with RNASE12: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for RNASE12 Gene

Orthologs for RNASE12 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RNASE12 35
  • 82.76 (n)
  • 68.28 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
OneToMany
RNASE12 35
  • 79.54 (n)
  • 71.72 (a)
mouse
(Mus musculus)
Mammalia Rnase12 35
  • 79.31 (n)
  • 68.28 (a)
Rnase12 16
Rnase12 36
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rnase12 35
  • 79.77 (n)
  • 71.03 (a)
Species with no ortholog for RNASE12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE12 Gene

ENSEMBL:
Gene Tree for RNASE12 (if available)
TreeFam:
Gene Tree for RNASE12 (if available)

Paralogs for RNASE12 Gene

Paralogs for RNASE12 Gene

Selected SIMAP similar genes for RNASE12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RNASE12: view

Variants for RNASE12 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE12 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
nsv901468 CNV Gain 21882294
nsv901469 CNV Loss 21882294

Relevant External Links for RNASE12 Gene

HapMap Linkage Disequilibrium report
RNASE12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for RNASE12 Gene

Disorders for RNASE12 Gene

No disorders were found for RNASE12 Gene.

No data available for UniProtKB/Swiss-Prot for RNASE12 Gene

Publications for RNASE12 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 3 4
  2. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RNASE12 Gene

Sources for RNASE12 Gene

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