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RNASE12 Gene

protein-coding   GIFtS: 34
GCID: GC14M021058

Ribonuclease, RNase A Family, 12 (Non-Active)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease, RNase A Family, 12 (Non-Active)1 2     Probable Inactive Ribonuclease-Like Protein 122
HEL-S-85p2     Ribonuclease A I12
RAI12     Ribonuclease-Like Protein 122
Epididymis Secretory Sperm Binding Protein Li 85p2     

External Ids:    HGNC: 242111   Entrez Gene: 4939012   Ensembl: ENSG000002584367   UniProtKB: Q5GAN43   

Export aliases for RNASE12 gene to outside databases

Previous GC identifers: GC14U900487 GC14M020129 GC14M001179


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RNASE12 Gene:
RNASE12 (ribonuclease, RNase A family, 12 (non-active)) is a protein-coding gene. Diseases associated with RNASE12 include pancreatitis. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding. An important paralog of this gene is ENSG00000259060.

UniProtKB/Swiss-Prot: RNS12_HUMAN, Q5GAN4
Function: Does not exhibit any ribonuclease activity (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE12 gene promoter:
         ISGF-3   Pbx1a   Nkx2-2   XBP-1   C/EBPalpha   Gfi-1   RORalpha2   PPAR-alpha   Cart-1   En-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RNASE12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.1   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RNASE12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE12 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021058:  view genomic region     (about GC identifiers)

Start:
21,058,239 bp from pter      End:
21,058,982 bp from pter
Size:
744 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RNS12_HUMAN, Q5GAN4 (See protein sequence)
Recommended Name: Probable inactive ribonuclease-like protein 12 precursor  
Size: 147 amino acids; 17177 Da

Explore the universe of human proteins at neXtProt for RNASE12: NX_Q5GAN4

Explore proteomics data for RNASE12 at MOPED


See RNASE12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001019993.1  
ENSEMBL proteins: 
 ENSP00000450580  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
RNASE: Ribonucleases, RNase A

2 InterPro protein domains:
 IPR023412 RNaseA_domain
 IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry Q5GAN4

ProtoNet protein and cluster: Q5GAN4

UniProtKB/Swiss-Prot: RNS12_HUMAN, Q5GAN4
Similarity: Belongs to the pancreatic ribonuclease family


RNASE12 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RNS12_HUMAN, Q5GAN4
Function: Does not exhibit any ribonuclease activity (Potential)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0016892endoribonuclease activity, producing 3'-phosphomonoesters IEA--
     
RNASE12 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RNS12_HUMAN, Q5GAN4: Secreted (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular4
plasma membrane2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

RNASE12 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASE12
Interactions:

    Search GeneGlobe Interaction Network for RNASE12

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for RNASE12 (RNS12)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RNASE12 gene: 
NM_001024822.2  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000556526(uc001vxt.3)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RNASE12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCTTCATCCA
RNASE12 Expression
About this image

RNASE12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RNASE12 Protein Expression
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for RNASE12 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnase121 , 5 ribonuclease, RNase A family, 12 (non-active)1, 5 79.31(n)1
68.28(a)1
  14 (26.36 cM)5
4971061  NM_001011875.21  NP_001011875.11 
 510567835 


ENSEMBL Gene Tree for RNASE12 (if available)
TreeFam Gene Tree for RNASE12 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RNASE12 gene
ENSG000002590602  
1 SIMAP similar gene for RNASE12 using alignment to 1 protein entry:     RNS12_HUMAN:
RNASE1

RNASE12 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RNASE12 (see all 13)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs49812611,2
C,F,A,H--21060447(+) GAATCC/GTGGAG 1 -- us2k132Minor allele frequency- G:0.40NA NS EA WA CSA 2898
rs1406978581,2
--21060452(+) CTGGAC/GAAGCC 1 -- us2k10--------
rs1860487301,2
--21060489(+) AAAAAC/TGAAAG 1 -- us2k10--------
rs49812621,2
C,F,A,H--21060502(+) AAATTT/GCAAAT 1 -- us2k129Minor allele frequency- G:0.24NS EA NA WA CSA 3132
rs49812641,2
C,F,A,H--21060565(+) GGGTGC/TCCTTT 1 -- us2k121Minor allele frequency- T:0.39NS EA NA WA 2346
rs49822371,2
C,F,A,H--21060580(+) ATTCAG/AACTAT 1 -- us2k114Minor allele frequency- A:0.34NS EA NA CSA WA 790
rs49812651,2
C,F,A,H--21060648(+) TGACAT/CGATTT 1 -- us2k127Minor allele frequency- C:0.39NS EA NA CSA WA 2772
rs1905019681,2
--21060681(+) GTACAC/TCTTGC 1 -- us2k10--------
rs1827349571,2
--21060735(+) TAACAA/TGTTCA 1 -- us2k10--------
rs1117189291,2
C,F--21060860(+) CCCTAG/AGGTAT 1 -- us2k11Minor allele frequency- A:0.01NA 120

HapMap Linkage Disequilibrium report for RNASE12 (21058239 - 21058982 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RNASE12:    About this table    
Variant IDTypeSubtypePubMed ID
nsv901469CNV Loss21882294
nsv901468CNV Gain21882294
esv23438CNV Gain+Loss19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for RNASE12:    
About MalaCards
pancreatitis


RNASE12 for disorders           About GeneDecksing


Export disorders for RNASE12 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RNASE12 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RNASE12)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1, 2 Cho S.... Zhang J. (Genomics 2005)
  2. Comparative genomic analysis of eutherian ribonuclease A genes. (PubMed id 24337645)1 Premzl M. (Mol. Genet. Genomics 2014)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 493901 HGNC: 24211 Ensembl:ENSG00000258436 euGenes: HUgn493901 ECgene: RNASE12
H-InvDB: RNASE12

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RNASE12 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RNASE12 gene:
Search GeneIP for patents involving RNASE12

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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