RNASE12 Gene
protein-coding GIFtS: 35
GCID: GC14M021058
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ribonuclease, RNase A family, 12 (non-active)
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Aliases
for RNASE12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ribonuclease, RNase A Family, 12 (Non-Active)1 2 | | Probable Inactive Ribonuclease-Like Protein 122 | | Ribonuclease-Like Protein 122 |
Export aliases for RNASE12 gene to outside databasesPrevious GC identifers: GC14U900487 GC14M020129 GC14M001179 |
Summaries
for RNASE12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RNS12_HUMAN, Q5GAN4Function: Does not exhibit any ribonuclease activity (Potential)
|
Genomic Views
for RNASE12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RNASE12 gene promoter:
ISGF-3 Pbx1a Nkx2-2 XBP-1 C/EBPalpha Gfi-1 RORalpha2 PPAR-alpha Cart-1 En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RNASE12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.1 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.1RNASE12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M021058: view genomic region
(about GC identifiers)
Start:
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21,058,239 bp from pter |
End:
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21,058,982 bp from pter |
Size:
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744 bases |
Orientation:
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minus strand |
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Proteins
for RNASE12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RNS12_HUMAN, Q5GAN4 (See
protein sequence)Recommended Name: Probable inactive ribonuclease-like protein 12 precursor Size: 147 amino acids; 17177 Da
Subcellular location: Secreted (Probable)Explore the universe of human proteins at neXtProt for RNASE12: NX_Q5GAN4
RNASE12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001019993.1
ENSEMBL proteins: ENSP00000372460
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
RNASE12 for ontologies About GeneDecksing
RNASE12 Antibody Products:
Assay Products for RNASE12: |
Protein
Domains /
Families
for RNASE12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RNASE12 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5GAN4ProtoNet protein and cluster: Q5GAN4 UniProtKB/Swiss-Prot: RNS12_HUMAN, Q5GAN4Similarity: Belongs to the pancreatic ribonuclease family |
Function
for RNASE12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RNS12_HUMAN, Q5GAN4Function: Does not exhibit any ribonuclease activity (Potential)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RNASE12 (NM_001024822) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE12 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
IEA | -- | | GO:0004522 | pancreatic ribonuclease activity |
IEA | -- |
RNASE12 for ontologies About GeneDecksing
|
Pathways & Interactions
for RNASE12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE12
|
Drugs & Compounds
for RNASE12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RNASE12
Search CenterWatch for drugs/clinical trials and news about RNASE12 / RNS12
|
Transcripts
for RNASE12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RNASE12 gene: NM_001024822.2 Unigene Cluster for RNASE12: Ribonuclease, RNase A family, 12 (non-active) Hs.729466 [show with all ESTs]Unigene Representative Sequence: NM_0010248221 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000382999
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE12 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RNASE12 (NM_001024822) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RNASE12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE12 |
Additional cDNA sequence: AY665807.1 BC130347.1 BC130349.1 3 DOTS entries: DT.404467 DT.426083 DT.100724585
GeneLoc Exon Structure
|
Expression
for RNASE12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RNASE12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTCATCCA
About this image
See RNASE12 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.729466
SABiosciences Custom PCR Arrays for RNASE12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASE12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE12 |
Orthologs
for RNASE12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for RNASE12 gene from 1/6 species (see all 6) About this table
ENSEMBL Gene Tree for RNASE12 (if available)
TreeFam Gene Tree for RNASE12 (if available) |
Paralogs
for RNASE12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RNASE12 gene
- RNASE102
2 SIMAP similar genes for RNASE12 using alignment to 1 protein entry: RNS12_HUMAN:RNASE1 RNASE10
RNASE12 for paralogs About GeneDecksing
|
Genomic Variants
for RNASE12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RNASE12 (21058239 - 21058982 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RNASE12
1 CNV: 71865 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE12 |
|
Disorders
/ Diseases
for RNASE12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RNASE12 for disorders About GeneDecksing
1  disease for RNASE12: About MalaCardspancreatitis
Export disorders for RNASE12 gene to outside databases
|
Publications
for RNASE12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RNASE12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNASE12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1, 2 Cho S.... Zhang J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RNASE12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RNASE12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RNASE12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RNASE12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RNASE12 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RNASE12 gene:
Search GeneIP for patents involving RNASE12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RNASE12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RNASE12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RNASE12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RNASE12 | | | OriGene Protein Over-expression Lysate for RNASE12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RNASE12 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RNASE12 | | OriGene Custom Protein Services for RNASE12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RNASE12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RNASE12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RNASE12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE12 |
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 |  |  |  | |
| | | | Search Tocris compounds for RNASE12 |
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 | | | RNASE12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE12 |
|  |  |  | | | | Search ThermoFisher Antibodies for RNASE12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE12 |
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