Set Analyses:
GeneALaCart
GeneDecks
VarElect
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 


RNASE11 Gene

protein-coding   GIFtS: 44
GCID: GC14M021051

Ribonuclease, RNase A Family, 11 (Non-Active)

(Previous name: chromosome 14 open reading frame 6)
(Previous symbol: C14orf6)
  See related disease
at
MalaCards
 

Aliases
for RNASE11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus
Aliases
Ribonuclease, RNase A Family, 11 (Non-Active)1 2     Epididymis Secretory Sperm Binding Protein Li 84p2
C14orf61 2 3     Probable Ribonuclease 112
RNase 112 3     Ribonuclease 112
Chromosome 14 Open Reading Frame 61     Ribonuclease A J12
HEL-S-84p2     EC 3.1.27.-3
RAJ12     

External Ids:    HGNC: 192691   Entrez Gene: 1226512   Ensembl: ENSG000001734647   UniProtKB: Q8TAA13   

Export aliases for RNASE11 gene to outside databases

Previous GC identifers: GC14M020121 GC14M001172


Summaries
for RNASE11 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus
GeneCards Summary for RNASE11 Gene:
RNASE11 (ribonuclease, RNase A family, 11 (non-active)) is a protein-coding gene. Diseases associated with RNASE11 include pancreatitis. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding.


Genomic Views
for RNASE11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE11 gene promoter:
         ISGF-3   Pbx1a   Nkx2-2   XBP-1   C/EBPalpha   Gfi-1   RORalpha2   PPAR-alpha   Cart-1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASE11 promoter sequence
   Search Chromatin IP Primers for RNASE11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RNASE11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE11 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021051:  view genomic region     (about GC identifiers)

Start:
 21,051,051 bp from pter      End:
 21,078,043 bp from pter
Size:
 26,993 bases      Orientation:
 minus strand

Proteins
for RNASE11 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus
UniProtKB/Swiss-Prot: RNS11_HUMAN, Q8TAA1 (See protein sequence)
Recommended Name: Probable ribonuclease 11 precursor  
Size: 199 amino acids; 22427 Da

Explore the universe of human proteins at neXtProt for RNASE11: NX_Q8TAA1

Explore proteomics data for RNASE11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See RNASE11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660293.1  
    ENSEMBL proteins: 
     ENSP00000451318   ENSP00000451563   ENSP00000381093   ENSP00000381092   ENSP00000395210  
     ENSP00000401398   ENSP00000451839   ENSP00000452412   ENSP00000415954   ENSP00000451466  
     ENSP00000476537  

    RNASE11 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RNASE11
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RNASE11
    GenScript Custom Purified and Recombinant Proteins Services for RNASE11
    Novus Biologicals RNASE11 Protein
    Novus Biologicals RNASE11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNASE11

    RNASE11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RNASE11
    Novus Biologicals RNASE11 Antibodies
    Abcam antibodies for RNASE11
    Cloud-Clone Corp. Antibodies for RNASE11
    ThermoFisher Antibodies for RNASE11
    LSBio Antibodies in human, mouse, rat for RNASE11

    RNASE11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RNASE11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RNASE11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNASE11
    Cloud-Clone Corp. CLIAs for RNASE11

    Domains /
    Families
    for RNASE11 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    RNASE: Ribonucleases, RNase A

    2 InterPro protein domains:
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry Q8TAA1

    ProtoNet protein and cluster: Q8TAA1

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNS11_HUMAN, Q8TAA1
    Similarity: Belongs to the pancreatic ribonuclease family


    RNASE11 for domains           About GeneDecksing


    Function
    for RNASE11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
         Enzyme Number (IUBMB): EC 3.1.27.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0016892endoribonuclease activity, producing 3'-phosphomonoesters IEA--
         
    RNASE11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNASE11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNASE11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RNASE11

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat RNASE11 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RNASE11:
    hsa-miR-1290 hsa-miR-483-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RNASE11 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for RNASE11
    Predesigned siRNA for gene silencing in human, mouse, rat RNASE11

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RNASE11

    Clone
    Products:             		 OriGene clones in human, mouse for RNASE11 (see all 6)
    OriGene ORF clones in mouse, rat for RNASE11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE11 (NM_145250)
    Sino Biological Human cDNA Clone for RNASE11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE11

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RNASE11
    Browse ESI BIO Cell Lines and PureStem Progenitors for RNASE11 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE11


    Localization
    for RNASE11 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
    Subcellular locations from UniProtKB/Swiss-Prot
    RNS11_HUMAN, Q8TAA1: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    RNASE11 for ontologies           About GeneDecksing


    Pathways & Interactions
    for RNASE11 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASE11
    Interactions:

        Search GeneGlobe Interaction Network for RNASE11

    Drugs & Compounds
    for RNASE11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RNASE11 (RNS11)



    Transcripts
    for RNASE11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus
    REFSEQ mRNAs for RNASE11 gene: 
    NM_145250.3  

    Unigene Cluster for RNASE11:

    Ribonuclease, RNase A family, 11 (non-active)
    Hs.112761  [show with all ESTs]
    Unigene Representative Sequence: NM_145250
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553849 ENST00000555841 ENST00000398009 ENST00000398008 ENST00000432835
    ENST00000443456 ENST00000557503 ENST00000557105 ENST00000413502 ENST00000554842
    ENST00000610205
    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat RNASE11 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RNASE11:
    hsa-miR-1290 hsa-miR-483-3p
    SwitchGear 3'UTR luciferase reporter plasmid: RNASE11 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for RNASE11
    Predesigned siRNA for gene silencing in human, mouse, rat RNASE11
    Clone
    Products:             		 OriGene clones in human, mouse for RNASE11 (see all 6)
    OriGene ORF clones in mouse, rat for RNASE11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RNASE11 (NM_145250)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE11
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for RNASE11
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASE11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE11
      QuantiTect SYBR Green Assays in human, mouse, rat RNASE11
      QuantiFast Probe-based Assays in human, mouse, rat RNASE11

    Additional mRNA sequence: 

    AK098687.1 AK292348.1 AK314065.1 AY358794.1 AY665806.1 BC025410.1 BX161458.1 

    6 DOTS entries:

    DT.404467  DT.303030  DT.100751196  DT.95069743  DT.95263792  DT.95338563 

    Selected AceView cDNA sequences (see all 42):

    NM_145250 BX398183 BP371081 BI831242 BX161458 AA609760 AY358794 BI825312 
    BG722557 BG717788 BI461508 AW188146 BG722274 AI809974 BI459952 BG773261 
    BX102349 AI478869 BX093877 BX368092 AW274139 BI459201 CB998266 BC025410 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNASE11 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
    SP1:        -     -     -     -     -     -     -     -     -           -                                             
    SP2:                    -     -     -     -     -     -     -           -                                             
    SP3:                                -     -     -     -     -           -                                             
    SP4:                                                        -           -                                             
    SP5:                                                  -     -           -                                             


    ECgene alternative splicing isoforms for RNASE11

    Expression
    for RNASE11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RNASE11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAATAGA
    RNASE11 Expression
    About this image

    RNASE11 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    RNASE11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.112761
        Custom PCR Arrays for RNASE11
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for RNASE11
    OriGene qSTAR qPCR primer pairs in human, mouse for RNASE11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE11
    QuantiTect SYBR Green Assays in human, mouse, rat RNASE11
    QuantiFast Probe-based Assays in human, mouse, rat RNASE11
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE11

    Orthologs
    for RNASE11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
    This gene was present in the common ancestor of human and mouse.

    Orthologs for RNASE11 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rnase111 , 5 ribonuclease, RNase A family, 11 (non-active)1, 5 68.54(n)1
    47.75(a)1    		   14 (26.36 cM)5
    4971131  NM_001011877.21  NP_001011877.11 
     510494515 


    ENSEMBL Gene Tree for RNASE11 (if available)
    TreeFam Gene Tree for RNASE11 (if available)

    Paralogs
    for RNASE11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus    		  --

    Genomic Variants
    for RNASE11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Selected SNPs for RNASE11 (see all 170)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs12436021,2
    		C,F,O,H--21050557(-) TTTCCT/GACAGT 1 -- ds500130Minor allele frequency- G:0.07NS EA NA WA CSA 2778
    rs1130222221,2
    		C,F--21050601(+) GAGGAG/AACTGC 1 -- ds50012Minor allele frequency- A:0.03CSA WA 120
    rs740343371,2
    		C,F--21050637(+) TCCACG/CCTTCT 1 -- ds50011Minor allele frequency- C:0.50WA 2
    rs762603501,2
    		C,F--21050656(+) AGTGGG/TTGGTA 1 -- ds50011Minor allele frequency- T:0.05NA 120
    rs1918599761,2
    		--21050776(+) GCATTA/TTGCTT 1 -- ds50010--------
    rs1506063581,2
    		--21050900(+) TCAAAC/TGTACA 1 -- ds50010--------
    rs71417471,2
    		C,F,A,H--21050921(+) TGTAAT/CGCTGC 1 -- ds500126Minor allele frequency- C:0.34NS EA NA WA CSA 2780
    rs71417651,2
    		C,F,A,H--21050947(+) AAATGT/ATTTAC 1 -- ds500110Minor allele frequency- A:0.13NS EA NA CSA WA 738
    rs1396981181,2
    		C--21050957(+) CAGTTA/C/GCAGTA 1 -- ds50010--------
    rs774209791,2
    		C,F--21050998(+) GCTTCG/AGGAAA 1 -- ds50011Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for RNASE11 (21051051 - 21078043 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RNASE11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901469CNV Loss21882294
    nsv901468CNV Gain21882294
    esv23438CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASE11
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE11

    Disorders / Diseases
    for RNASE11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    1 disease for RNASE11:    
    About MalaCards
    pancreatitis


    RNASE11 for disorders           About GeneDecksing


    Export disorders for RNASE11 gene to outside databases

    Publications
    for RNASE11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus
    PubMed articles for RNASE11 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with RNASE11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Comparative genomic analysis of eutherian ribonuclease A genes. (PubMed id 24337645)1 Premzl M. (Mol. Genet. Genomics 2014)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1 Cho S.... Zhang J. (Genomics 2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. (PubMed id )2 

    External Searches for RNASE11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RNASE11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 122651 HGNC: 19269 AceView: C14orf6 Ensembl:ENSG00000173464 euGenes: HUgn122651
    ECgene: RNASE11 H-InvDB: RNASE11

    Other Databases showing RNASE11 gene

    (According to HUGE)
    About This Section

    TryGeneCards Plus    		   --

    Specialized Databases showing RNASE11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RNASE11 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNASE11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for RNASE11 gene:
    Search GeneIP for patents involving RNASE11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for RNASE11 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for RNASE11  
     OriGene qPCR primer pairs and template standards for RNASE11   OriGene Protein Over-expression Lysate for RNASE11  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RNASE11  
     OriGene qSTAR qPCR primer pairs in human, mouse for RNASE11   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RNASE11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RNASE11   OriGene Custom Protein Services for RNASE11  

         		 
     Block miRNA regulation of human, mouse, rat RNASE11 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RNASE11
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE11 Predesigned siRNA for gene silencing in human, mouse, rat RNASE11
     QuantiFast Probe-based Assays in human, mouse, rat RNASE11 QuantiTect SYBR Green Assays in human, mouse, rat RNASE11
     Custom PCR Arrays for RNASE11 Search Chromatin IP Primers for RNASE11
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RNASE11  Search GeneGlobe Interaction Network for RNASE11
     Regulatory tfbs in RNASE11 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RNASE11 GenScript cDNA clones with any tag delivered in your preferred vector for RNASE11
     GenScript Custom Assay Services for RNASE11 GenScript Custom overexpressing Cell Line Services for RNASE11
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for RNASE11 (RNS11)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RNASE11
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RNASE11 antibodies
     RNASE11 proteins
     RNASE11 lysates
     Antibodies for RNASE11
     See all of Abcam's Antibodies, Kits and Proteins for RNASE11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RNASE11
     Antibodies for RNASE11
     ELISAs for RNASE11
     CLIAs for RNASE11



     Browse ESI BIO Cell Lines and PureStem Progenitors for RNASE11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE11
     SwitchGear 3'UTR luciferase reporter plasmids for RNASE11
     SwitchGear Promoter luciferase reporter plasmids for RNASE11
     ThermoFisher Antibodies for RNASE11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE11
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RNASE11
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RNASE11
     LSBio Antibodies in human, mouse, rat for RNASE11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      RNASE11 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4