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Aliases for RNASE11 Gene

Aliases for RNASE11 Gene

  • Ribonuclease A Family Member 11 (Inactive) 2 3
  • Ribonuclease, RNase A Family, 11 (Non-Active) 2 3 5
  • RNase 11 3 4
  • C14orf6 3 4
  • Epididymis Secretory Sperm Binding Protein Li 84p 3
  • Chromosome 14 Open Reading Frame 6 2
  • Ribonuclease A J1 3
  • Ribonuclease 11 3
  • EC 3.1.27.- 4
  • HEL-S-84p 3
  • RAJ1 3

External Ids for RNASE11 Gene

Previous HGNC Symbols for RNASE11 Gene

  • C14orf6

Previous GeneCards Identifiers for RNASE11 Gene

  • GC14M020121
  • GC14M021051
  • GC14M001172

Summaries for RNASE11 Gene

GeneCards Summary for RNASE11 Gene

RNASE11 (Ribonuclease A Family Member 11 (Inactive)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE11 Gene

Genomics for RNASE11 Gene

Regulatory Elements for RNASE11 Gene

Promoters for RNASE11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RNASE11 on UCSC Golden Path with GeneCards custom track

Genomic Location for RNASE11 Gene

Chromosome:
14
Start:
20,582,892 bp from pter
End:
20,609,884 bp from pter
Size:
26,993 bases
Orientation:
Minus strand

Genomic View for RNASE11 Gene

Genes around RNASE11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE11 Gene

Proteins for RNASE11 Gene

  • Protein details for RNASE11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAA1-RNS11_HUMAN
    Recommended name:
    Probable ribonuclease 11
    Protein Accession:
    Q8TAA1

    Protein attributes for RNASE11 Gene

    Size:
    199 amino acids
    Molecular mass:
    22427 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE11 Gene

Proteomics data for RNASE11 Gene at MOPED

Post-translational modifications for RNASE11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RNASE11 Gene

Domains & Families for RNASE11 Gene

Gene Families for RNASE11 Gene

Protein Domains for RNASE11 Gene

Suggested Antigen Peptide Sequences for RNASE11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAA1

UniProtKB/Swiss-Prot:

RNS11_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE11: view

Function for RNASE11 Gene

Enzyme Numbers (IUBMB) for RNASE11 Gene

Gene Ontology (GO) - Molecular Function for RNASE11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with RNASE11: view
genes like me logo Genes that share phenotypes with RNASE11: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE11 Gene

Localization for RNASE11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE11 Gene COMPARTMENTS Subcellular localization image for RNASE11 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for RNASE11 Gene

Pathways & Interactions for RNASE11 Gene

SuperPathways for RNASE11 Gene

No Data Available

Interacting Proteins for RNASE11 Gene

Gene Ontology (GO) - Biological Process for RNASE11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNASE11 Gene

Drugs & Compounds for RNASE11 Gene

No Compound Related Data Available

Transcripts for RNASE11 Gene

Unigene Clusters for RNASE11 Gene

Ribonuclease, RNase A family, 11 (non-active):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE11 Gene

No ASD Table

Relevant External Links for RNASE11 Gene

GeneLoc Exon Structure for
RNASE11
ECgene alternative splicing isoforms for
RNASE11

Expression for RNASE11 Gene

mRNA expression in normal human tissues for RNASE11 Gene

mRNA differential expression in normal tissues according to GTEx for RNASE11 Gene

This gene is overexpressed in Testis (x52.7).

SOURCE GeneReport for Unigene cluster for RNASE11 Gene Hs.112761

genes like me logo Genes that share expression patterns with RNASE11: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RNASE11 Gene

Orthologs for RNASE11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASE11 35
  • 79.75 (n)
  • 65.59 (a)
RNASE11 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnase11 35
  • 68.54 (n)
  • 47.75 (a)
Rnase11 16
Rnase11 36
  • 48 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNASE11 35
  • 99.16 (n)
  • 97.99 (a)
RNASE11 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnase11 35
  • 67.05 (n)
  • 44.57 (a)
Species with no ortholog for RNASE11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE11 Gene

ENSEMBL:
Gene Tree for RNASE11 (if available)
TreeFam:
Gene Tree for RNASE11 (if available)

Paralogs for RNASE11 Gene

No data available for Paralogs for RNASE11 Gene

Variants for RNASE11 Gene

Sequence variations from dbSNP and Humsavar for RNASE11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs17113756 - 20,584,462(+) CAGAG(A/G)AAAGG reference, missense
rs35818240 - 20,584,255(-) CTTCC(A/C/T)CATTA reference, missense
rs1261801 -- 20,583,094(-) TTATG(A/C)TACTG utr-variant-3-prime
rs1243599 -- 20,582,990(-) TGTGG(A/C/T)CATAT utr-variant-3-prime
rs1243600 -- 20,582,916(-) TTTAA(A/C)TAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNASE11 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
nsv901468 CNV Gain 21882294
nsv901469 CNV Loss 21882294

Variation tolerance for RNASE11 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE11 Gene

HapMap Linkage Disequilibrium report
RNASE11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE11 Gene

Disorders for RNASE11 Gene

Relevant External Links for RNASE11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE11

No disorders were found for RNASE11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE11 Gene

Publications for RNASE11 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 2 3 67
  2. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for RNASE11 Gene

Sources for RNASE11 Gene

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