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Aliases for RNASE11 Gene

Aliases for RNASE11 Gene

  • Ribonuclease A Family Member 11 (Inactive) 2 3 5
  • Ribonuclease, RNase A Family, 11 (Non-Active) 2 3
  • RNase 11 3 4
  • C14orf6 3 4
  • Epididymis Secretory Sperm Binding Protein Li 84p 3
  • Chromosome 14 Open Reading Frame 6 2
  • Probable Ribonuclease 11 3
  • Ribonuclease A J1 3
  • Ribonuclease 11 3
  • EC 3.1.27.- 4
  • HEL-S-84p 3
  • RAJ1 3

External Ids for RNASE11 Gene

Previous HGNC Symbols for RNASE11 Gene

  • C14orf6

Previous GeneCards Identifiers for RNASE11 Gene

  • GC14M020121
  • GC14M021051
  • GC14M001172

Summaries for RNASE11 Gene

GeneCards Summary for RNASE11 Gene

RNASE11 (Ribonuclease A Family Member 11 (Inactive)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease activity.

Additional gene information for RNASE11 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE11 Gene

Genomics for RNASE11 Gene

Regulatory Elements for RNASE11 Gene

Enhancers for RNASE11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H020426 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +181.8 181777 2.7 NFIB ARID4B BATF FOS ETV6 RUNX3 IKZF2 CREM SMARCA5 SP5 OSGEP PNP PIP4P1 APEX1 RNASE11 TEP1 KLHL33 RNASE6 RNASE3 GC14P020415
GH14H020475 1.4 Ensembl ENCODE dbSUPER 11 +132.3 132257 3.4 HDAC1 NFIB FEZF1 GLI4 TCF12 GATA2 RCOR1 ETV6 ZBTB2 CEBPB RNASE10 APEX1 OSGEP TEP1 RNA5SP382 RNASE11 PNP ENSG00000258908
GH14H020453 1.2 ENCODE 11.2 +154.3 154342 3.9 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SUPT16H METTL17 OSGEP ENSG00000258515 APEX1 TEP1 PIP4P1 ZNF219 RNASE9 RNASE12
GH14H020531 0.9 ENCODE 11.3 +78.7 78718 0.2 FOXA2 ZNF2 RAD21 GATA2 ZNF366 ZNF143 ETV6 ZNF654 ZBTB2 ZNF114 LINC00641 RNASE9 RNASE12 OR11G2 CKAP2P1 OR4K6P OR11K2P OR4M1 OR4H12P OR4N2
GH14H020375 0.9 ENCODE 10.6 +231.4 231421 6.7 ELF3 FOXA2 MLX ARID4B DMAP1 RAD21 RARA MIXL1 THAP11 MXD4 TEP1 RNA5SP382 CCNB1IP1 SNORD126 RNASE11 ENSG00000259001 SNORA79B ENSG00000254846
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNASE11 on UCSC Golden Path with GeneCards custom track

Promoters for RNASE11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066379 -16 1401 PKNOX1 MLX ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Locations for RNASE11 Gene

Genomic Locations for RNASE11 Gene
chr14:20,582,892-20,609,884
(GRCh38/hg38)
Size:
26,993 bases
Orientation:
Minus strand
chr14:21,051,051-21,078,043
(GRCh37/hg19)

Genomic View for RNASE11 Gene

Genes around RNASE11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE11 Gene

Proteins for RNASE11 Gene

  • Protein details for RNASE11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAA1-RNS11_HUMAN
    Recommended name:
    Probable ribonuclease 11
    Protein Accession:
    Q8TAA1

    Protein attributes for RNASE11 Gene

    Size:
    199 amino acids
    Molecular mass:
    22427 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE11 Gene

Post-translational modifications for RNASE11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNASE11 Gene

Domains & Families for RNASE11 Gene

Gene Families for RNASE11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE11 Gene

Suggested Antigen Peptide Sequences for RNASE11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAA1

UniProtKB/Swiss-Prot:

RNS11_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE11: view

Function for RNASE11 Gene

Enzyme Numbers (IUBMB) for RNASE11 Gene

Gene Ontology (GO) - Molecular Function for RNASE11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 NOT ribonuclease activity IKR 15676279
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RNASE11: view
genes like me logo Genes that share phenotypes with RNASE11: view

Animal Model Products

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE11 Gene

Localization for RNASE11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE11 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE11 Gene

Pathways & Interactions for RNASE11 Gene

SuperPathways for RNASE11 Gene

No Data Available

Interacting Proteins for RNASE11 Gene

Selected Interacting proteins: Q8TAA1-RNS11_HUMAN for RNASE11 Gene via IID

Symbol External ID(s) Details
APP

Gene Ontology (GO) - Biological Process for RNASE11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RNASE11: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE11 Gene

Drugs & Compounds for RNASE11 Gene

No Compound Related Data Available

Transcripts for RNASE11 Gene

Unigene Clusters for RNASE11 Gene

Ribonuclease, RNase A family, 11 (non-active):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE11 Gene

No ASD Table

Relevant External Links for RNASE11 Gene

GeneLoc Exon Structure for
RNASE11
ECgene alternative splicing isoforms for
RNASE11

Expression for RNASE11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE11 Gene

mRNA differential expression in normal tissues according to GTEx for RNASE11 Gene

This gene is overexpressed in Testis (x52.7).

NURSA nuclear receptor signaling pathways regulating expression of RNASE11 Gene:

RNASE11

SOURCE GeneReport for Unigene cluster for RNASE11 Gene:

Hs.112761
genes like me logo Genes that share expression patterns with RNASE11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE11 Gene

Orthologs for RNASE11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE11 33 34
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia RNASE11 33 34
  • 79.75 (n)
mouse
(Mus musculus)
Mammalia Rnase11 33 16 34
  • 68.54 (n)
rat
(Rattus norvegicus)
Mammalia Rnase11 33
  • 67.05 (n)
Species where no ortholog for RNASE11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE11 Gene

ENSEMBL:
Gene Tree for RNASE11 (if available)
TreeFam:
Gene Tree for RNASE11 (if available)

Paralogs for RNASE11 Gene

No data available for Paralogs for RNASE11 Gene

Variants for RNASE11 Gene

Sequence variations from dbSNP and Humsavar for RNASE11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000174679 -- 20,587,001(+) AACAA(A/C)AAAAA intron-variant, upstream-variant-2KB
rs1000432270 -- 20,586,220(+) GTGAC(C/T)CTTTT intron-variant
rs1000484859 -- 20,586,550(+) ATTAT(G/T)AAGAA intron-variant, upstream-variant-2KB
rs1000579594 -- 20,582,539(+) GGATG(A/G)AACTC downstream-variant-500B
rs1001147152 -- 20,588,065(+) CCTTT(A/G)TTTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE11 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for RNASE11 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE11 Gene

Disorders for RNASE11 Gene

Relevant External Links for RNASE11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE11

No disorders were found for RNASE11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE11 Gene

Publications for RNASE11 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S … Zhang J (Genomics 2005) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  5. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M (Molecular genetics and genomics : MGG 2014) 3 60

Products for RNASE11 Gene

Sources for RNASE11 Gene

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