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Aliases for RNASE11 Gene

Aliases for RNASE11 Gene

  • Ribonuclease, RNase A Family, 11 (Non-Active) 2 3
  • RNase 11 3 4
  • C14orf6 3 4
  • Epididymis Secretory Sperm Binding Protein Li 84p 3
  • Chromosome 14 Open Reading Frame 6 2
  • Probable Ribonuclease 11 3
  • Ribonuclease A J1 3
  • Ribonuclease 11 3
  • EC 3.1.27.- 4
  • HEL-S-84p 3
  • RAJ1 3

External Ids for RNASE11 Gene

Previous Symbols for RNASE11 Gene

  • C14orf6

Summaries for RNASE11 Gene

GeneCards Summary for RNASE11 Gene

RNASE11 (Ribonuclease, RNase A Family, 11 (Non-Active)) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is RNASE12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE11 Gene

Genomics for RNASE11 Gene

Genomic Location for RNASE11 Gene

Start:
20,582,892 bp from pter
End:
20,609,795 bp from pter
Size:
26,904 bases
Orientation:
Minus strand

Genomic View for RNASE11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE11 Gene

Regulatory Elements for RNASE11 Gene

Proteins for RNASE11 Gene

  • Protein details for RNASE11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAA1-RNS11_HUMAN
    Recommended name:
    Probable ribonuclease 11
    Protein Accession:
    Q8TAA1
    Secondary Accessions:

    Protein attributes for RNASE11 Gene

    Size:
    199 amino acids
    Molecular mass:
    22427 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE11 Gene

Proteomics data for RNASE11 Gene at MOPED

Post-translational modifications for RNASE11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNASE11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE11 Gene

Domains for RNASE11 Gene

Gene Families for RNASE11 Gene

HGNC:
  • RNASE :Ribonucleases, RNase A

Protein Domains for RNASE11 Gene

UniProtKB/Swiss-Prot:

RNS11_HUMAN
Family:
  • Belongs to the pancreatic ribonuclease family.:
    • Q8TAA1
genes like me logo Genes that share domains with RNASE11: view

Function for RNASE11 Gene

Enzyme Numbers (IUBMB) for RNASE11 Gene

Gene Ontology (GO) - Molecular Function for RNASE11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity IBA --
genes like me logo Genes that share ontologies with RNASE11: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RNASE11 Gene

Localization for RNASE11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE11 Gene COMPARTMENTS Subcellular localization image for RNASE11 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for RNASE11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE11: view

Pathways for RNASE11 Gene

SuperPathways for RNASE11 Gene

No Data Available

Interacting Proteins for RNASE11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338288%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000338288 for RNASE11 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for RNASE11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IBA --
GO:0090501 RNA phosphodiester bond hydrolysis IBA --
genes like me logo Genes that share ontologies with RNASE11: view

No data available for Pathways by source for RNASE11 Gene

Transcripts for RNASE11 Gene

Unigene Clusters for RNASE11 Gene

Ribonuclease, RNase A family, 11 (non-active):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE11 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: -

Relevant External Links for RNASE11 Gene

GeneLoc Exon Structure for
RNASE11
ECgene alternative splicing isoforms for
RNASE11

Expression for RNASE11 Gene

mRNA expression in normal human tissues for RNASE11 Gene

mRNA differential expression in normal tissues according to GTEx for RNASE11 Gene

This gene is overexpressed in Testis (52.7).

SOURCE GeneReport for Unigene cluster for RNASE11 Gene Hs.112761

genes like me logo Genes that share expressions with RNASE11: view

Orthologs for RNASE11 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 35 (a)
OneToMany
RNASE11 36
  • 99.16 (n)
  • 97.99 (a)
cow
(Bos Taurus)
Mammalia RNASE11 36
  • 79.75 (n)
  • 65.59 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 22 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rnase11 36
  • 68.54 (n)
  • 47.75 (a)
Rnase11 16
Rnase12 37
  • 21 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 8 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rnase11 36
  • 67.05 (n)
  • 44.57 (a)
Species with no ortholog for RNASE11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE11 Gene

ENSEMBL:
Gene Tree for RNASE11 (if available)
TreeFam:
Gene Tree for RNASE11 (if available)

Paralogs for RNASE11 Gene

Paralogs for RNASE11 Gene

genes like me logo Genes that share paralogs with RNASE11: view

Variants for RNASE11 Gene

Sequence variations from dbSNP and Humsavar for RNASE11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1243599 -- 20,582,990(-) TGTGG(A/C)CATAT utr-variant-3-prime
rs1243600 -- 20,582,916(-) TTTAA(A/C)TAAAT utr-variant-3-prime
rs1243601 -- 20,582,868(-) TTTCT(A/T)GTACA downstream-variant-500B
rs1243602 -- 20,582,398(-) TTTCC(G/T)ACAGT downstream-variant-500B
rs1261801 -- 20,583,094(-) TTATG(A/C)TACTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNASE11 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545
nsv901468 CNV Gain 21882294
nsv901469 CNV Loss 21882294

Relevant External Links for RNASE11 Gene

HapMap Linkage Disequilibrium report
RNASE11

Disorders for RNASE11 Gene

No disorders were found for RNASE11 Gene.

No data available for UniProtKB/Swiss-Prot for RNASE11 Gene

Publications for RNASE11 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for RNASE11 Gene

Sources for RNASE11 Gene

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