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RNASE11 Gene

protein-coding GIFtS: 44
GCID: GC14M021051

Ribonuclease, RNase A Family, 11 (Non-Active)

(Previous name: chromosome 14 open reading frame 6)
(Previous symbol: C14orf6)

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MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, 11 (Non-Active)¹ ²		Epididymis Secretory Sperm Binding Protein Li 84p²
C14orf6¹ ² ³		Probable Ribonuclease 11²
RNase 11² ³		Ribonuclease 11²
Chromosome 14 Open Reading Frame 6¹		Ribonuclease A J1²
HEL-S-84p²		EC 3.1.27.-³
RAJ1²

External Ids:	HGNC: 19269¹	Entrez Gene: 122651²	Ensembl: ENSG00000173464⁷	UniProtKB: Q8TAA1³

Export aliases for RNASE11 gene to outside databases

Previous GC identifers: GC14M020121 GC14M001172

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNASE11 Gene:

RNASE11 (ribonuclease, RNase A family, 11 (non-active)) is a protein-coding gene. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000014.8 NC_018925.2 NT_026437.13

Regulatory elements:

Regulatory transcription factor binding sites in the RNASE11 gene promoter:
ISGF-3 Pbx1a Nkx2-2 XBP-1 C/EBPalpha Gfi-1 RORalpha2 PPAR-alpha Cart-1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASE11 promoter sequence

Search Chromatin IP Primers for RNASE11

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.1

RNASE11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE11 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M021051: view genomic region (about GC identifiers)

Start:	21,051,051 bp from pter	End:	21,078,043 bp from pter
Size:	26,993 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
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About This Section

UniProtKB/Swiss-Prot: RNS11_HUMAN, Q8TAA1 (See protein sequence)

Recommended Name: Probable ribonuclease 11 precursor

Size: 199 amino acids; 22427 Da

Explore the universe of human proteins at neXtProt for RNASE11: NX_Q8TAA1

Explore proteomics data for RNASE11 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See RNASE11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_660293.1

ENSEMBL proteins:

ENSP00000451318 ENSP00000451563 ENSP00000381093 ENSP00000381092 ENSP00000395210

ENSP00000401398 ENSP00000451839 ENSP00000452412 ENSP00000415954 ENSP00000451466

ENSP00000476537

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

RNASE: Ribonucleases, RNase A

2 InterPro protein domains:

IPR023412 RNaseA_domain

IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry Q8TAA1

ProtoNet protein and cluster: Q8TAA1

1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

UniProtKB/Swiss-Prot: RNS11_HUMAN, Q8TAA1

Similarity: Belongs to the pancreatic ribonuclease family

Find genes that share domains with RNASE11 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Enzyme Number (IUBMB): EC 3.1.27.-¹

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	IEA	--
GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters	IEA	--

Find genes that share ontologies with RNASE11 About GenesLikeMe

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

RNS11_HUMAN, Q8TAA1: Secreted (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	3

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

Find genes that share ontologies with RNASE11 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

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Interactions:

Search GeneGlobe Interaction Network for RNASE11

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for RNASE11 gene:

NM_145250.3

Unigene Cluster for RNASE11:

Ribonuclease, RNase A family, 11 (non-active)

Hs.112761 [show with all ESTs]

Unigene Representative Sequence: NM_145250

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000553849 ENST00000555841 ENST00000398009 ENST00000398008 ENST00000432835

ENST00000443456 ENST00000557503 ENST00000557105 ENST00000413502 ENST00000554842

ENST00000610205

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Additional mRNA sequence:

AK098687.1 AK292348.1 AK314065.1 AY358794.1 AY665806.1 BC025410.1 BX161458.1

6 DOTS entries:

DT.404467 DT.303030 DT.100751196 DT.95069743 DT.95263792 DT.95338563

Selected AceView cDNA sequences (see all 42):

NM_145250 BX398183 BP371081 BI831242 BX161458 AA609760 AY358794 BI825312

BG722557 BG717788 BI461508 AW188146 BG722274 AI809974 BI459952 BG773261

BX102349 AI478869 BX093877 BX368092 AW274139 BI459201 CB998266 BC025410

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RNASE11 (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f	·	7g
SP1:			-		-		-		-		-		-		-		-		-				-
SP2:							-		-		-		-		-		-		-				-
SP3:											-		-		-		-		-				-
SP4:																			-				-
SP5:																	-		-				-

ECgene alternative splicing isoforms for RNASE11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASE11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAAGAATAGA

About this image

RNASE11 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RNASE11 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.112761

Custom PCR Arrays for RNASE11

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for RNASE11 gene from Selected species (see all 4) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rnase11^{1 , 5}	ribonuclease, RNase A family, 11 (non-active)^{1, 5}	68.54(n)¹ 47.75(a)¹		14 (26.36 cM)⁵ 497113¹ NM_001011877.2¹ NP_001011877.1¹ 51049451⁵

ENSEMBL Gene Tree for RNASE11 (if available)
TreeFam Gene Tree for RNASE11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1243602^1,2	C,F,O,H	--	21050557(-)	`TTTCCT/GACAGT`	1	--	ds500¹		30		NS EA NA WA CSA	2778
rs113022222^1,2	C,F	--	21050601(+)	`GAGGAG/AACTGC`	1	--	ds500¹		2		CSA WA	120
rs74034337^1,2	C,F	--	21050637(+)	`TCCACG/CCTTCT`	1	--	ds500¹		1		WA	2
rs76260350^1,2	C,F	--	21050656(+)	`AGTGGG/TTGGTA`	1	--	ds500¹		1		NA	120
rs191859976^1,2		--	21050776(+)	`GCATTA/TTGCTT`	1	--	ds500¹		0	--	--	--	--
rs150606358^1,2		--	21050900(+)	`TCAAAC/TGTACA`	1	--	ds500¹		0	--	--	--	--
rs7141747^1,2	C,F,A,H	--	21050921(+)	`TGTAAT/CGCTGC`	1	--	ds500¹		26		NS EA NA WA CSA	2780
rs7141765^1,2	C,F,A,H	--	21050947(+)	`AAATGT/ATTTAC`	1	--	ds500¹		10		NS EA NA CSA WA	738
rs139698118^1,2	C	--	21050957(+)	`CAGTTA/C/GCAGTA`	1	--	ds500¹		0	--	--	--	--
rs77420979^1,2	C,F	--	21050998(+)	`GCTTCG/AGGAAA`	1	--	ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for RNASE11 (21051051 - 21078043 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RNASE11: About this table

Variant ID	Type	Subtype	PubMed ID
nsv901469	CNV	Loss	21882294
nsv901468	CNV	Gain	21882294
esv23438	CNV	Gain+Loss	19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RNASE11 gene integrated from 10 sources:
(articles sorted by number of sources associating them with RNASE11)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (Genome Res. 2003)
Comparative genomic analysis of eutherian ribonuclease A genes. (PubMed id 24337645)¹ Premzl M. (Mol. Genet. Genomics 2014)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)¹ Cho S.... Zhang J. (Genomics 2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
(PubMed id )²

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 122651	HGNC: 19269	AceView: C14orf6	Ensembl:ENSG00000173464	euGenes: HUgn122651
ECgene: RNASE11	H-InvDB: RNASE11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RNASE11	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RNASE11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RNASE11 gene:
Search GeneIP for patents involving RNASE11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section


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RNASE11 Gene

Ribonuclease, RNase A Family, 11 (Non-Active)

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RNASE11 Gene

Ribonuclease, RNase A Family, 11 (Non-Active)

Aliasesfor RNASE11 gene

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RNASE11 Human Recombinant Protein Products:

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