Aliases for RNASE11 Gene
Aliases for RNASE11 Gene
External Ids for RNASE11 Gene
- HGNC: 19269
- Entrez Gene: 122651
- Ensembl: ENSG00000173464
- UniProtKB: Q8TAA1
Previous HGNC Symbols for RNASE11 Gene
- C14orf6
Previous GeneCards Identifiers for RNASE11 Gene
- GC14M020121
- GC14M021051
- GC14M001172
Summaries for RNASE11 Gene
GeneCards Summary for RNASE11 Gene
RNASE11 (Ribonuclease A Family Member 11 (Inactive)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity.
Additional gene information for RNASE11 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE11 Gene
Genomics for RNASE11 Gene
GeneHancer (GH) Regulatory Elements for RNASE11 Gene
Promoters and enhancers for RNASE11 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14I020609 | Promoter/Enhancer | 1.6 | Ensembl ENCODE | 550.8 | +0.0 | 34 | 1.8 | PKNOX1 MLX ARNT ARID4B NEUROD1 SIN3A ZNF2 IRF4 YY1 SLC30A9 | ENSG00000259060 RNASE11 TRL-AAG2-3 TRP-AGG2-5 PARP2 SUPT16H METTL3 TTC5 ENSG00000258515 CHD8 | |
| GH14I020608 | Enhancer | 0.5 | ENCODE | 550.8 | +1.0 | 1031 | 0.1 | ZNF148 ZNF366 ZNF512 EBF1 | ENSG00000259060 RNASE11 TRL-AAG2-3 TRP-AGG2-5 RNASE12 | |
| GH14I020587 | Promoter | 0.5 | EPDnew | 550.3 | +22.1 | 22139 | 0.1 | LOC254028 RNASE11 RNASE12 ENSG00000259060 | ||
| GH14I020585 | Promoter | 0.5 | EPDnew | 550.3 | +24.7 | 24741 | 0.1 | RNASE11 LOC254028 GC14P020572 PIR38570 ENSG00000259060 | ||
| GH14I020426 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 11.1 | +181.8 | 181776 | 2.7 | NFIB ARID4B BATF IRF4 ETV6 FOS BCLAF1 IKZF2 RUNX3 SMARCA5 | OSGEP PNP PIP4P1 APEX1 RNASE11 TEP1 KLHL33 RNASE6 RNASE3 GC14P020415 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RNASE11 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RNASE11 gene promoter:
Regulatory Element Products
Genomic Locations for RNASE11 Gene
Genomic Locations for RNASE11 Gene
- chr14:20,582,892-20,609,884
- (GRCh38/hg38)
- Size:
- 26,993 bases
- Orientation:
- Minus strand
- chr14:21,051,051-21,078,043
- (GRCh37/hg19)
Genomic View for RNASE11 Gene
Genes around RNASE11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
RNASE11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNASE11 Gene
Proteins for RNASE11 Gene
-
Protein details for RNASE11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TAA1-RNS11_HUMAN
- Recommended name:
- Probable ribonuclease 11
- Protein Accession:
- Q8TAA1
Protein attributes for RNASE11 Gene
- Size:
- 199 amino acids
- Molecular mass:
- 22427 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for RNASE11 Gene
No Post-translational modifications
Other Protein References for RNASE11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RNASE11
-
Cloud-Clone Corp. Antibodies for RNASE11
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Protein Products
-
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-
Cloud-Clone Corp. Proteins for RNASE11
- Search GeneTex for Proteins for RNASE11
-
Abcam proteins for RNASE11
Assay Products
No data available for DME Specific Peptides for RNASE11 Gene
Domains & Families for RNASE11 Gene
Gene Families for RNASE11 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for RNASE11 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNASE11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TAA1- Family:
-
- Belongs to the pancreatic ribonuclease family.
Function for RNASE11 Gene
Enzyme Numbers (IUBMB) for RNASE11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004519 | endonuclease activity | IBA | -- |
| GO:0004540 | NOT ribonuclease activity | IKR | 15676279 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for RNASE11 Gene
- GenomeRNAi human phenotypes for RNASE11:
Animal Model Products
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for RNASE11
- genomics-online: gRNA clones - Search results for 97 available RNASE11 gene related products
- Overview of 97 available RNASE11 gene related products
- Applied Biological Materials CRISPR for RNASE11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNASE11
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miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for 97 available RNASE11 gene related products
- Overview of 97 available RNASE11 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RNASE11 gene
Clone Products
- Sino Biological Human cDNA Clone for RNASE11
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RNASE11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNASE11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RNASE11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RNASE11
-
ViGene Biosciences adenoviral particle packaged cDNA for RNASE11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RNASE11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RNASE11 gene
No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE11 Gene
Localization for RNASE11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNASE11 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE11 Gene
Pathways & Interactions for RNASE11 Gene
No Data Available
Interacting Proteins for RNASE11 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| APP |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0090305 | nucleic acid phosphodiester bond hydrolysis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for RNASE11 Gene
Transcripts for RNASE11 Gene
mRNA/cDNA for RNASE11 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (42) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RNASE11 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RNASE11
- genomics-online: gRNA clones - Search results for 97 available RNASE11 gene related products
- Overview of 97 available RNASE11 gene related products
- Applied Biological Materials CRISPR for RNASE11
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNASE11
- GenScript: Design CRISPR guide RNA sequences for RNASE11
miRNA Products
- Search ViGene Biosciences for RNASE11
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RNASE11
- Browse OriGene Inhibitory RNA Products For RNASE11
- genomics-online: shRNA clones - Search results for 97 available RNASE11 gene related products
- Overview of 97 available RNASE11 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RNASE11 gene
Clone Products
- Sino Biological Human cDNA Clone for RNASE11
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RNASE11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNASE11
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RNASE11
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RNASE11 Gene
mRNA differential expression in normal tissues according to GTEx for RNASE11 Gene
This gene is overexpressed in Testis (x52.7).
NURSA nuclear receptor signaling pathways regulating expression of RNASE11 Gene:
RNASE11SOURCE GeneReport for Unigene cluster for RNASE11 Gene:
Hs.112761Primer Products
-
OriGene qPCR primer pairs for RNASE11
-
OriGene qPCR primer pairs and template standards for RNASE11
- genomics-online: primer clones - Search results for 97 available RNASE11 gene related products
- Overview of 97 available RNASE11 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE11 Gene
Orthologs for RNASE11 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RNASE11 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RNASE11 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rnase11 34 16 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Rnase11 33 |
|
- Species where no ortholog for RNASE11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for RNASE11 Gene
No data available for Paralogs for RNASE11 Gene
Variants for RNASE11 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000174679 | -- | 20,587,001(-) | C/A | intron_variant | |
| rs1000432270 | -- | 20,586,220(-) | T/C | intron_variant | |
| rs1000484859 | -- | 20,586,550(-) | T/G | intron_variant | |
| rs1000579594 | -- | 20,582,539(-) | G/A | downstream_transcript_variant | |
| rs1001147152 | -- | 20,588,065(-) | A/G | intron_variant |
Residual Variation Intolerance Score:
82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.99;
49.78% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RNASE11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNASE11
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE11 Gene
Disorders for RNASE11 Gene
Additional Disease Information for RNASE11
No disorders were found for RNASE11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE11 Gene
Publications for RNASE11 Gene
- The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S … Zhang J (Genomics 2005) 2 3 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
- Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M (Molecular genetics and genomics : MGG 2014) 3 58
Products for RNASE11 Gene
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- Custom Antibody ServicesOriGene Antibodies for RNASE11
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- Invitrogen Antibodies for RNASE11
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNASE11
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- GeneTex RNASE11 antibody for RNASE11
- Search GeneTex for Proteins for RNASE11
- ViGene Biosciences adenoviral particle packaged cDNA for RNASE11 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RNASE11 gene
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- genomics-online: cdna clones - Search results for 97 available RNASE11 gene related products
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- Overview of 97 available RNASE11 gene related products
Sources for RNASE11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew