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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE10 Gene

protein-coding   GIFtS: 40
GCID: GC14P021034

Ribonuclease, RNase A Family, 10 (Non-Active)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonuclease, RNase A Family, 10 (Non-Active)1 2
RNASE92
Inactive Ribonuclease-Like Protein 102
Ribonuclease 102
Ribonuclease-Like Protein 102

External Ids:    HGNC: 192751   Entrez Gene: 3388792   Ensembl: ENSG000001825457   UniProtKB: Q5GAN63   

Export aliases for RNASE10 gene to outside databases

Previous GC identifers: GC14P020049 GC14P021022 GC14P001099 GC14P021023 GC14P021027 GC14P021030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RNASE10 Gene: 
RNASE10 (ribonuclease, RNase A family, 10 (non-active)) is a protein-coding gene. Diseases associated with RNASE10 include orchitis, and azoospermia. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding.

UniProtKB/Swiss-Prot: RNS10_HUMAN, Q5GAN6
Function: Not known; does not have ribonuclease activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE10 gene promoter:
         NF-1   NF-1/L   USF1   AML1a   USF2   USF-1:USF-2   USF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE10 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASE10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RNASE10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE10 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021034:  view genomic region     (about GC identifiers)

Start:
20,973,696 bp from pter      End:
20,979,328 bp from pter
Size:
5,633 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNS10_HUMAN, Q5GAN6 (See protein sequence)
Recommended Name: Inactive ribonuclease-like protein 10 precursor  
Size: 216 amino acids; 24008 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: A2RUQ3

Explore the universe of human proteins at neXtProt for RNASE10: NX_Q5GAN6

Explore proteomics data for RNASE10 at MOPED 

RNASE10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

RNASE10 Protein Expression

REFSEQ proteins: NP_001012993.1  
ENSEMBL proteins: 
 ENSP00000392996   ENSP00000333358  

Human Recombinant Protein Products for RNASE10: 
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Cloud-Clone Corp. Proteins for RNASE10 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

RNASE10 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
RNASE: Ribonucleases, RNase A

2 InterPro protein domains:
 IPR023412 RNaseA_domain
 IPR001427 RNaseA

Graphical View of Domain Structure for InterPro Entry Q5GAN6

ProtoNet protein and cluster: Q5GAN6

UniProtKB/Swiss-Prot: RNS10_HUMAN, Q5GAN6
Similarity: Belongs to the pancreatic ribonuclease family


RNASE10 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: RNS10_HUMAN, Q5GAN6
Function: Not known; does not have ribonuclease activity (By similarity)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding IEA--
GO:0004522pancreatic ribonuclease activity IEA--
     
RNASE10 for ontologies           About GeneDecksing


Phenotypes:
     6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rnase10):
 endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  reproductive system 
 skeleton 

RNASE10 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE10 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE10

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RNASE10 
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miRNA
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE10

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
EMD Millipore small molecules for RNASE10:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RNASE10 (RNS10)

Search CenterWatch for drugs/clinical trials and news about RNASE10 / RNS10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RNASE10 gene: 
NM_001012975.1  

Unigene Cluster for RNASE10:

Ribonuclease, RNase A family, 10 (non-active)
Hs.451057
Unigene Representative Sequence: AK296766
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000430083(uc001vxp.2) ENST00000328444(uc010tlj.2)
miRNA
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Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RNASE10
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RNASE10
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE10

Additional mRNA sequence: 

AK296766.1 AY665805.1 BC133002.1 BC133028.1 

1 DOTS entry:

DT.99970749 

1 AceView cDNA sequence:

BQ938117 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RNASE10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGCGCCAGT
RNASE10 Expression
About this image


See RNASE10 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.451057
    SABiosciences Custom PCR Arrays for RNASE10
Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for RNASE10
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RNASE10
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for RNASE10 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rnase101 , 5 ribonuclease, RNase A family, 10 (non-active)1, 5 76.65(n)1
68.12(a)1
  14 (26.34 cM)5
750191  NM_001162863.11  NP_001156335.11 
 510077515 


ENSEMBL Gene Tree for RNASE10 (if available)
TreeFam Gene Tree for RNASE10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for RNASE10 gene
1 SIMAP similar gene for RNASE10 using alignment to 2 protein entries:     RNS10_HUMAN (see all proteins):
RNASE12

RNASE10 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/95 SNPs in RNASE10 are shown (see all 95)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1496780371,2
C--20976723(+) ATAGCC/TGCAAA 1 -- us2k10--------
rs1835192481,2
--20976785(+) AGTGCC/TCCGTT 1 -- us2k10--------
rs1896373141,2
--20976835(+) GGGGGA/GAAAAA 1 -- us2k10--------
rs1812352561,2
--20976836(+) GGGGGA/GAAAAC 1 -- us2k10--------
rs80167341,2
C,A--20976841(+) aaaaaC/Tatgct 1 -- us2k17Minor allele frequency- T:0.33WA NA CSA 246
rs1868813071,2
--20976944(+) TAATAC/TATATT 1 -- us2k10--------
rs1455054801,2
--20976947(+) TATATA/GTTACT 1 -- us2k10--------
rs1918279401,2
--20976977(+) TGTAGA/GTATGT 1 -- us2k10--------
rs780425631,2
C,F--20977100(+) CATACG/TTTTAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1435106821,2
--20977286(+) GCACCA/CTCTTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for RNASE10 (20973696 - 20979328 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for RNASE10:    About this table     
Variant IDTypeSubtypePubMed ID
esv23438CNV Gain+Loss19812545

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
3 diseases for RNASE10:    About MalaCards
orchitis    azoospermia    pancreatitis

1 disease from the University of Copenhagen DISEASES database for RNASE10:
Orchitis

RNASE10 for disorders           About GeneDecksing

Genetic Association Database (GAD): RNASE10

Export disorders for RNASE10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for RNASE10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with RNASE10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PubMed id 15676279)1, 2 Cho S.... Zhang J. (2005)
  2. Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PubMed id 12920233)1, 3 Penttinen J....Poutanen M. (2003)
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PubMed id 17903296)4 Kiel D.P....Karasik D. (2007)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 338879 HGNC: 19275 AceView: LOC338879 Ensembl:ENSG00000182545 euGenes: HUgn338879
ECgene: RNASE10 H-InvDB: RNASE10

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for RNASE10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for RNASE10 gene:
Search GeneIP for patents involving RNASE10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

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 Search LifeMap BioReagents cell lines for RNASE10
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 Codon Optimization
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE10
 Browse SwitchGear 3'UTR luciferase reporter plasmids for RNASE10
 SwitchGear Promoter luciferase reporter plasmids for RNASE10
 Search ThermoFisher Antibodies for RNASE10
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE10
 inGenious Targeting Laboratory - Custom generated mouse model solutions for RNASE10
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RNASE10
Customized:
 lentivirus for stable overexpression of RNASE10
 lentivirus expression plasmids for stable overexpression of RNASE10
 adenovirus for overexpression of RNASE10
 Search LSBio for Antibodies for RNASE10
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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