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Aliases for RNASE10 Gene

Aliases for RNASE10 Gene

  • Ribonuclease, RNase A Family, 10 (Non-Active) 2 3
  • Ribonuclease A H1 3
  • RNASE9 3
  • RAH1 3

External Ids for RNASE10 Gene

Previous GeneCards Identifiers for RNASE10 Gene

  • GC14P020049
  • GC14P021022
  • GC14P001099
  • GC14P021023
  • GC14P021027
  • GC14P021030
  • GC14P021034
  • GC14P021037

Summaries for RNASE10 Gene

GeneCards Summary for RNASE10 Gene

RNASE10 (Ribonuclease, RNase A Family, 10 (Non-Active)) is a Protein Coding gene. Diseases associated with RNASE10 include orchitis. GO annotations related to this gene include nucleic acid binding and ribonuclease activity.

UniProtKB/Swiss-Prot for RNASE10 Gene

  • Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE10 Gene

Genomics for RNASE10 Gene

Regulatory Elements for RNASE10 Gene

Genomic Location for RNASE10 Gene

Chromosome:
14
Start:
20,505,537 bp from pter
End:
20,511,169 bp from pter
Size:
5,633 bases
Orientation:
Plus strand

Genomic View for RNASE10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE10 Gene

Proteins for RNASE10 Gene

  • Protein details for RNASE10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GAN6-RNS10_HUMAN
    Recommended name:
    Inactive ribonuclease-like protein 10
    Protein Accession:
    Q5GAN6
    Secondary Accessions:
    • A2RUQ3
    • B4DKY4

    Protein attributes for RNASE10 Gene

    Size:
    216 amino acids
    Molecular mass:
    24008 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNASE10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASE10 Gene

Proteomics data for RNASE10 Gene at MOPED

Post-translational modifications for RNASE10 Gene

Other Protein References for RNASE10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RNASE10 Gene

Domains & Families for RNASE10 Gene

Gene Families for RNASE10 Gene

Protein Domains for RNASE10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASE10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GAN6

UniProtKB/Swiss-Prot:

RNS10_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE10: view

Function for RNASE10 Gene

Molecular function for RNASE10 Gene

UniProtKB/Swiss-Prot Function:
Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).

Gene Ontology (GO) - Molecular Function for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 NOT endonuclease activity IBA --
GO:0004540 NOT ribonuclease activity IKR 15676279
genes like me logo Genes that share ontologies with RNASE10: view
genes like me logo Genes that share phenotypes with RNASE10: view

Animal Model Products

miRNA for RNASE10 Gene

miRTarBase miRNAs that target RNASE10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE10 Gene

Localization for RNASE10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE10 Gene COMPARTMENTS Subcellular localization image for RNASE10 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE10: view

Pathways & Interactions for RNASE10 Gene

SuperPathways for RNASE10 Gene

No Data Available

Interacting Proteins for RNASE10 Gene

Gene Ontology (GO) - Biological Process for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis IEA --
GO:0007338 single fertilization IEA --
GO:0008584 male gonad development --
GO:0022409 positive regulation of cell-cell adhesion ISS --
GO:0034113 heterotypic cell-cell adhesion ISS --
genes like me logo Genes that share ontologies with RNASE10: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE10 Gene

Drugs & Compounds for RNASE10 Gene

No Compound Related Data Available

Transcripts for RNASE10 Gene

mRNA/cDNA for RNASE10 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE10 Gene

Ribonuclease, RNase A family, 10 (non-active):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RNASE10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE10 Gene

No ASD Table

Relevant External Links for RNASE10 Gene

GeneLoc Exon Structure for
RNASE10
ECgene alternative splicing isoforms for
RNASE10

Expression for RNASE10 Gene

mRNA expression in normal human tissues for RNASE10 Gene

mRNA differential expression in normal tissues according to GTEx for RNASE10 Gene

This gene is overexpressed in Testis (x4.3).

Protein differential expression in normal tissues from HIPED for RNASE10 Gene

This gene is overexpressed in Plasma (47.2) and Heart (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE10 Gene



SOURCE GeneReport for Unigene cluster for RNASE10 Gene Hs.451057

genes like me logo Genes that share expression patterns with RNASE10: view

Protein tissue co-expression partners for RNASE10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNASE10 Gene

Orthologs for RNASE10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RNASE10 35
  • 79.46 (n)
  • 66.82 (a)
RNASE10 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNASE10 35
  • 75.86 (n)
  • 68.22 (a)
RNASE10 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnase10 35
  • 76.65 (n)
  • 68.12 (a)
Rnase10 16
Rnase10 36
  • 56 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RNASE10 35
  • 98.77 (n)
  • 97.22 (a)
RNASE10 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnase10 35
  • 77.08 (n)
  • 67.31 (a)
Species with no ortholog for RNASE10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE10 Gene

ENSEMBL:
Gene Tree for RNASE10 (if available)
TreeFam:
Gene Tree for RNASE10 (if available)

Paralogs for RNASE10 Gene

No data available for Paralogs for RNASE10 Gene

Variants for RNASE10 Gene

Sequence variations from dbSNP and Humsavar for RNASE10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2067648 - 20,510,863(-) TCTGA(A/C/T)TGGGC missense, reference
rs2319197 -- 20,510,285(+) GTGGT(A/G)GGGAG upstream-variant-2KB
rs2319198 -- 20,510,372(+) CCCCA(A/G)ATACA upstream-variant-2KB
rs8016734 -- 20,508,682(+) aaaaa(C/T)atgct upstream-variant-2KB
rs9788427 -- 20,509,240(+) GATGG(G/T)GTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RNASE10 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545

Variation tolerance for RNASE10 Gene

Residual Variation Intolerance Score: 77.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNASE10 Gene

HapMap Linkage Disequilibrium report
RNASE10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE10 Gene

Disorders for RNASE10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNASE10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
orchitis
  • inflammation of testis
- elite association

Relevant External Links for RNASE10

Genetic Association Database (GAD)
RNASE10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNASE10
genes like me logo Genes that share disorders with RNASE10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE10 Gene

Publications for RNASE10 Gene

  1. Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PMID: 12920233) Penttinen J. … Poutanen M. (Mol. Endocrinol. 2003) 2 67
  2. Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. (PMID: 24811271) Kennedy R.B. … Poland G.A. (Immunogenetics 2014) 67
  3. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 67
  4. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 67
  5. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 67

Products for RNASE10 Gene

Sources for RNASE10 Gene

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