Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNASE10 Gene

Aliases for RNASE10 Gene

  • Ribonuclease, RNase A Family, 10 (Non-Active) 2 3
  • Inactive Ribonuclease-Like Protein 10 3
  • Ribonuclease A H1 3
  • RNASE9 3
  • RAH1 3

External Ids for RNASE10 Gene

Summaries for RNASE10 Gene

GeneCards Summary for RNASE10 Gene

RNASE10 (Ribonuclease, RNase A Family, 10 (Non-Active)) is a Protein Coding gene. Diseases associated with RNASE10 include orchitis. GO annotations related to this gene include nucleic acid binding and ribonuclease A activity.

UniProtKB/Swiss-Prot for RNASE10 Gene

  • Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE10 Gene

Genomics for RNASE10 Gene

Genomic Location for RNASE10 Gene

Start:
20,505,537 bp from pter
End:
20,511,169 bp from pter
Size:
5,633 bases
Orientation:
Plus strand

Genomic View for RNASE10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE10 Gene

Regulatory Elements for RNASE10 Gene

Proteins for RNASE10 Gene

  • Protein details for RNASE10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GAN6-RNS10_HUMAN
    Recommended name:
    Inactive ribonuclease-like protein 10
    Protein Accession:
    Q5GAN6
    Secondary Accessions:
    • A2RUQ3
    • B4DKY4

    Protein attributes for RNASE10 Gene

    Size:
    216 amino acids
    Molecular mass:
    24008 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNASE10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASE10 Gene

Proteomics data for RNASE10 Gene at MOPED

Post-translational modifications for RNASE10 Gene

Other Protein References for RNASE10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE10 Gene

Domains for RNASE10 Gene

Gene Families for RNASE10 Gene

HGNC:
  • RNASE :Ribonucleases, RNase A

Protein Domains for RNASE10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASE10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5GAN6

UniProtKB/Swiss-Prot:

RNS10_HUMAN
Family:
  • Belongs to the pancreatic ribonuclease family.:
    • Q5GAN6
genes like me logo Genes that share domains with RNASE10: view

Function for RNASE10 Gene

Molecular function for RNASE10 Gene

UniProtKB/Swiss-Prot Function: Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).

Gene Ontology (GO) - Molecular Function for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 ribonuclease activity IBA --
genes like me logo Genes that share ontologies with RNASE10: view
genes like me logo Genes that share phenotypes with RNASE10: view

miRNA for RNASE10 Gene

miRTarBase miRNAs that target RNASE10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNASE10 Gene

Localization for RNASE10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE10 Gene COMPARTMENTS Subcellular localization image for RNASE10 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE10: view

Pathways for RNASE10 Gene

SuperPathways for RNASE10 Gene

No Data Available

Interacting Proteins for RNASE10 Gene

Gene Ontology (GO) - Biological Process for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis IEA --
GO:0007338 single fertilization IEA --
GO:0008584 male gonad development --
GO:0022409 positive regulation of cell-cell adhesion ISS --
GO:0034113 heterotypic cell-cell adhesion ISS --
genes like me logo Genes that share ontologies with RNASE10: view

No data available for Pathways by source for RNASE10 Gene

Transcripts for RNASE10 Gene

mRNA/cDNA for RNASE10 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE10 Gene

Ribonuclease, RNase A family, 10 (non-active):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE10 Gene

No ASD Table

Relevant External Links for RNASE10 Gene

GeneLoc Exon Structure for
RNASE10
ECgene alternative splicing isoforms for
RNASE10

Expression for RNASE10 Gene

mRNA expression in normal human tissues for RNASE10 Gene

mRNA differential expression in normal tissues according to GTEx for RNASE10 Gene

This gene is overexpressed in Testis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for RNASE10 Gene

SOURCE GeneReport for Unigene cluster for RNASE10 Gene Hs.451057

genes like me logo Genes that share expressions with RNASE10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RNASE10 Gene

Orthologs for RNASE10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE10 35
  • 98.77 (n)
  • 97.22 (a)
RNASE10 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNASE10 35
  • 79.46 (n)
  • 66.82 (a)
RNASE10 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNASE10 35
  • 75.86 (n)
  • 68.22 (a)
RNASE10 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnase10 35
  • 76.65 (n)
  • 68.12 (a)
Rnase10 16
Rnase10 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnase10 35
  • 77.08 (n)
  • 67.31 (a)
Species with no ortholog for RNASE10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE10 Gene

ENSEMBL:
Gene Tree for RNASE10 (if available)
TreeFam:
Gene Tree for RNASE10 (if available)

Paralogs for RNASE10 Gene

No data available for Paralogs for RNASE10 Gene

Variants for RNASE10 Gene

Sequence variations from dbSNP and Humsavar for RNASE10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2067648 - 20,510,863(-) TCTGA(C/T)TGGGC missense, reference
rs2319197 -- 20,510,285(+) GTGGT(A/G)GGGAG upstream-variant-2KB, intron-variant
rs2319198 -- 20,510,372(+) CCCCA(A/G)ATACA upstream-variant-2KB, intron-variant
rs4981223 -- 20,503,625(+) TGATA(A/G)TGCTG upstream-variant-2KB
rs7140999 -- 20,505,865(+) ggaag(C/T)gagga utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RNASE10 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545

Relevant External Links for RNASE10 Gene

HapMap Linkage Disequilibrium report
RNASE10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE10 Gene

Disorders for RNASE10 Gene

(1) MalaCards Diseases for RNASE10 Gene

Search for RNASE10 Gene in MalaCards »

(1) University of Copenhagen DISEASES for RNASE10 Gene

Relevant External Links for RNASE10

Genetic Association Database (GAD)
RNASE10
genes like me logo Genes that share disorders with RNASE10: view

No data available for UniProtKB/Swiss-Prot for RNASE10 Gene

Publications for RNASE10 Gene

  1. Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PMID: 12920233) Penttinen J. … Poutanen M. (Mol. Endocrinol. 2003) 2 3
  2. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S. … Zhang J. (Genomics 2005) 3 4
  3. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M. (Mol. Genet. Genomics 2014) 3
  4. Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. (PMID: 24811271) Kennedy R.B. … Poland G.A. (Immunogenetics 2014) 3
  5. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel D.P. … Karasik D. (BMC Med. Genet. 2007) 48

Products for RNASE10 Gene

Sources for RNASE10 Gene

Back to Top

Content