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RNASE1 Gene

protein-coding   GIFtS: 62
GCID: GC14M021269

Ribonuclease, RNase A Family, 1 (Pancreatic)


(Previous symbol: RNS1)
  See RNASE1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonuclease, RNase A Family, 1 (Pancreatic)1 2     RNase 12 3
RNS11 2 3 5     RNase A2 3
Ribonuclease 12 3     EC 3.1.27.53 8
RNase UpI-12 3     RAC12
HP-RNase2 3     Ribonuclease A C12
RIB-12 3     Ribonuclease Pancreatic2
RIB12 3     Ribonuclease A3

External Ids:    HGNC: 100441   Entrez Gene: 60352   Ensembl: ENSG000001295387   OMIM: 1804405   UniProtKB: P079983   

Export aliases for RNASE1 gene to outside databases

Previous GC identifers: GC14M018641 GC14M015056 GC14M019259 GC14M020339 GC14M001390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RNASE1 Gene:
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A
superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine
bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The
encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at
this locus and four transcript variants encoding the same protein have been identified. (provided by RefSeq, Jul
2008)

GeneCards Summary for RNASE1 Gene:
RNASE1 (ribonuclease, RNase A family, 1 (pancreatic)) is a protein-coding gene. Diseases associated with RNASE1 include gyrate atrophy, and osteogenesis imperfecta type iii. GO annotations related to this gene include pancreatic ribonuclease activity and nucleic acid binding. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot: RNAS1_HUMAN, P07998
Function: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on
single-stranded and double-stranded RNA

summary for RNASE1 Gene:
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras
proto-oncogene superfamily. The Ras superfamily contains over 100 small GTPases grouped into eight families;
Ras, Rho, Rab, Rap, Arf, Ran, Rheb and Rad. Small GTPases regulate a wide variety of processes in the cell,
including growth, differentiation, movement and lipid vesicle transport. Like Galpha proteins, small GTPases
alternate between an 'on' state (bound to GTP) and an 'off' state (bound to GDP). This cyclic process
requires guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP). Small GTPases are the
downstream effectors of most receptor tyrosine kinases (RTKs) and are linked via two proteins, GRB2 and SOS.
They are coupled to intracellular signaling cascades including the MAPK pathway, through interactions with
Raf kinase. Normally, activation of small GTPases is induced by ligand binding to a RTK. In many transformed
cells activating mutations of GTPases, often Ras, produce a cellular response in the absence of a ligand,
thus promoting malignant progression.

Gene Wiki entry for RNASE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the RNASE1 gene promoter:
         AREB6   ER-alpha   S8   COMP1   Lmo2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRNASE1 promoter sequence
   Search Chromatin IP Primers for RNASE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RNASE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

RNASE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021269:  view genomic region     (about GC identifiers)

Start:
21,269,387 bp from pter      End:
21,271,437 bp from pter
Size:
2,051 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RNAS1_HUMAN, P07998 (See protein sequence)
Recommended Name: Ribonuclease pancreatic precursor  
Size: 156 amino acids; 17644 Da
Subunit: Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may
occur. Interaction with RNH1 inhibits this protein
Selected PDB 3D structures from and Proteopedia for RNASE1 (see all 12):
1DZA (3D)        1E21 (3D)        1H8X (3D)        1Z7X (3D)        2E0J (3D)        2E0L (3D)    
Secondary accessions: B2R589 D3DS06 Q16830 Q16869 Q1KHR2 Q6ICS5 Q9UCB4 Q9UCB5

Explore the universe of human proteins at neXtProt for RNASE1: NX_P07998

Explore proteomics data for RNASE1 at MOPED

Post-translational modifications: 

  • N-linked glycans are of complex type1
  • Glycosylation2 at Asn62, Asn104, Asn116
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RNASE1 (P07998) (see all 13)
     IIVACEG  CKPVNTF  RRNMTQG  MHITDCR 


    See RNASE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_002924.1  NP_937875.1  NP_937877.1  NP_937878.1  

    ENSEMBL proteins: 
     ENSP00000381057   ENSP00000344193   ENSP00000399493   ENSP00000451058   ENSP00000381060  

    RNASE1 Human Recombinant Protein Products:

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    Novus Biologicals RNASE1 Proteins
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    Sino Biological Recombinant Protein for RNASE1
    Sino Biological Cell Lysate for RNASE1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RNASE1

     
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    antibodies-online proteins for RNASE1 (42 products) 

     
    antibodies-online peptides for RNASE1

    RNASE1 Antibody Products:

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    antibodies-online antibodies for RNASE1 (59 products) 

    RNASE1 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RNASE1
    Cloud-Clone Corp. CLIAs for RNASE1
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    antibodies-online kits for RNASE1 (31 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNASE: Ribonucleases, RNase A

    3 InterPro protein domains:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P07998

    ProtoNet protein and cluster: P07998

    1 Blocks protein domain: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNAS1_HUMAN, P07998
    Similarity: Belongs to the pancreatic ribonuclease family


    Find genes that share domains with RNASE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNAS1_HUMAN, P07998
    Function: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on
    single-stranded and double-stranded RNA
    Catalytic activity: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in
    Cp or Up with 2',3'-cyclic phosphate intermediates

         Genatlas biochemistry entry for RNASE1:
    ribonuclease RNAse A family,1,secretory,pancreatic with a dimeric mutant selectively cytotoxic for malignant cells

         Enzyme Number (IUBMB): EC 3.1.27.51 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0005515protein binding IPI17350650
    GO:0016892endoribonuclease activity, producing 3'-phosphomonoesters ----
         
    Find genes that share ontologies with RNASE1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RNASE1

    miRNA
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    miRTarBase miRNAs that target RNASE1:
    hsa-mir-26b-5p (MIRT028796)

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    SwitchGear 3'UTR luciferase reporter plasmidRNASE1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 4): RNASE1 (NM_198234)
    Sino Biological Human cDNA Clone for RNASE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RNASE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RNASE1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNAS1_HUMAN, P07998: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    nucleus2
    chloroplast1
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with RNASE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RNASE1 (see all 76)
        Fc-GammaR Pathway
    Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    JNK Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RNASE1
    Interactions:

        Search GeneGlobe Interaction Network for RNASE1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for RNASE1 (P079981, 2, 3 ENSP000003441934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNH1P134891, 3, ENSP000003464024EBI-2823523,EBI-1237106 I2D: score=3 STRING: ENSP00000346402
    CANXP278243I2D: score=2 
    LRRC34ENSP000003261504STRING: ENSP00000326150
    RELAENSP000003842734STRING: ENSP00000384273
    --Q91YW32MINT-7299594
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic TAS8049276

    Find genes that share ontologies with RNASE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RNASE1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    QS 11ARFGAP1 inhibitor; modulates Wnt/beta-catenin signaling[944328-88-5]
    NSC 23766Selective inhibitor of Rac1-GEF interaction; antioncogenic[733767-34-5]
    EHT 1864Potent inhibitor of Rac family GTPases[754240-09-0]
    SecinH3Sec7-specific GEF inhibitor (cytohesins)[853625-60-2]
    Rac1 Inhibitor W56Selective inhibitor of Rac1-GEF interaction[1095179-01-3]

    Selected DrugBank Compounds for RNASE1 (see all 28)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    GuanidineAminomethanamidine (see all 9)113-00-8target--8700871 7986344 17139284 16302208 17016423 10592235
    1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione-- --target--17139284 17016423 10592235
    1-(3-O-Phosphono-Beta-L-Arabinofuranosyl)Pyrimidine-2,4(1h,3h)-Dione-- --target--17139284 17016423 10592235
    2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate-- --target--17139284 17016423 10592235
    2'-Deoxyuridine 3'-Monophosphate-- --target--17139284 17016423 10592235
    2'-Monophosphoadenosine-5'-Diphosphate-- --target--17139284 17016423 10592235
    2-Methyl-2-Propanol-- --target--17139284 17016423 10592235
    3'-Phosphate-Adenosine-5'-Diphosphate-- --target--17139284 17016423 10592235
    3'-Uridinemonophosphate-- --target--17139284 17016423 10592235
    5-Amino-1h-Pyrimidine-2,4-Dione-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for RNASE1 gene (see all 94)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine-2'-monophosphate 89.8 7 11746706 (1), 15210951 (1), 14729124 (1), 15245999 (1) (see all 7)
    2-cmp 80.8 8 12023520 (2), 17957392 (2), 14729124 (1), 8286064 (1)
    5'-diphosphoadenosine 3'-phosphate 80.2 1 10441122 (1)
    poly c 75.4 12 17416340 (3), 7756988 (2), 9481869 (1), 10336457 (1) (see all 7)
    3'-uridinemonophosphate 72.3 1 15670155 (1)
    poly u 70.5 9 9481869 (1), 8643340 (1), 10336457 (1), 9399152 (1) (see all 6)
    2',5'-adp 55.4 2 14573867 (2)
    uridine 53 3 8037446 (1), 14573867 (1), 11456753 (1)
    pyrimidine 51 7 9578571 (2), 8159680 (1), 9358156 (1), 9918722 (1) (see all 5)
    trna 50.8 7 1377751 (2), 1400510 (2), 7685766 (1), 9422763 (1) (see all 5)



    Find genes that share compounds with RNASE1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RNASE1 gene (4 alternative transcripts): 
    NM_002933.4  NM_198232.2  NM_198234.2  NM_198235.2  

    Unigene Cluster for RNASE1:

    Ribonuclease, RNase A family, 1 (pancreatic)
    Hs.78224  [show with all ESTs]
    Unigene Representative Sequence: CF595800
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397967(uc001vyi.3) ENST00000340900(uc001vyg.3 uc001vyh.3)
    ENST00000412779(uc001vyf.3) ENST00000555698 ENST00000397970
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat RNASE1

    Additional mRNA sequence: 

    AK098375.1 AK129871.1 AK312100.1 BC005324.1 BC022882.1 CR450318.1 S79281.1 

    13 DOTS entries:

    DT.449353  DT.97854772  DT.91997790  DT.101985031  DT.100826933  DT.100826934  DT.92456205  DT.95267775 
    DT.120767275  DT.92411048  DT.120767280  DT.95267781  DT.91945313 

    Selected AceView cDNA sequences (see all 439):

    BI835457 R79191 NM_198234 BP373045 BI834388 BM782203 BQ082640 BM769735 
    BM826989 BC005324 H24768 CA413889 AV710596 BM669071 CB153187 BQ549737 
    BM924057 BM834823 AI989933 BU682989 H20105 BM422347 BM769638 BI753463 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RNASE1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
    SP1:              -                                       
    SP2:              -     -                                 
    SP3:              -     -     -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for RNASE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RNASE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAACCCCTC
    RNASE1 Expression
    About this image


    RNASE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Lung (Respiratory System)
             Alveolar type II cells
    RNASE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RNASE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78224

    UniProtKB/Swiss-Prot: RNAS1_HUMAN, P07998
    Tissue specificity: Pancreas and other tissues and body fluids (indicating it may have other physiological
    functions besides its role in digestion)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RNASE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rnase11 , 5 ribonuclease, RNase A family, 1 (pancreatic)1, 5 81.06(n)1
    71.97(a)1
      14 (26.40 cM)5
    197521  NM_011271.21  NP_035401.21 
     511450025 
    chicken
    (Gallus gallus)
    Aves RSFR6
    CL26
    (see all 3)
    Gallus gallus liver ribonuclease A (CL2), mRNA.
    (see all 3)
    32(a)
    31(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    6(8804970-8806179)
    4(49041665-49042706)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    41(a)
    30(a)
    many ↔ many
    many ↔ many
    GL343220.1(1531632-1532063)
    GL343220.1(1279015-1279452)


    ENSEMBL Gene Tree for RNASE1 (if available)
    TreeFam Gene Tree for RNASE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for RNASE1 gene
    RNASE32  RNASE82  RNASE72  RNASE22  ANG2  RNASE62  RNASE42  
    7 SIMAP similar genes for RNASE1 using alignment to 2 protein entries:     RNAS1_HUMAN (see all proteins):
    RAB1    RNASE4    RNASE12    ANG    RNASE6    RNASE7
    RNASE8

    Find genes that share paralogs with RNASE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RNASE1 (see all 97)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881916051,2
    --21269044(+) TTCTGG/TCTCTA 4 -- ds50010--------
    rs735820011,2
    C,F--21269171(+) CTTCCC/TCACCC 4 -- ds50014Minor allele frequency- T:0.15WA CSA 124
    rs1932648481,2
    --21269303(+) CCCTTG/TTGTCT 4 -- ds50010--------
    rs740346091,2
    C,F--21269503(+) CAGAAC/ACGCTT 4 -- ds50015Minor allele frequency- A:0.46WA CSA 127
    rs172543521,2
    C,F,H--21269507(+) ACCGCT/CTCAGA 4 -- ds50018Minor allele frequency- C:0.03NA NS EA 668
    rs1118169051,2
    C--21269514(+) CAGAAT/ATCAGG 4 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1854259501,2
    --21269525(+) TGTTTG/TCAACT 4 -- ut310--------
    rs740346101,2
    C--21269612(+) GCAGGG/AATGGG 4 -- ut312Minor allele frequency- A:0.08WA 120
    rs1379348381,2
    --21269629(+) GAAAGA/GGAAGC 4 -- ut310--------
    rs1895555441,2
    --21269637(+) AGCATA/GTGTGT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for RNASE1 (21269387 - 21271437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RNASE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428293CNV Gain+Loss18775914
    dgv607e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RNASE1
    DNA2.0 Custom Variant and Variant Library Synthesis for RNASE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180440    OMIM disorders: --

    2 diseases for RNASE1:    
    About MalaCards
    gyrate atrophy    osteogenesis imperfecta type iii

    1 disease from the University of Copenhagen DISEASES database for RNASE1:
    Gyrate atrophy

    Find genes that share disorders with RNASE1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RNASE1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteogenesis imperfecta 25.2 1 8444468 (1)
    malignant mesothelioma 20.1 2 16188273 (1), 16313179 (1)
    neovascularization 15.6 6 17916583 (1), 19354288 (1), 19173562 (1), 7874290 (1) (see all 5)
    immunodeficiency 10.2 4 2034672 (2), 1377751 (1), 8016107 (1)
    erythroleukemia 9.39 1 17350650 (1)
    asthma 1.81 1 19189375 (1)
    carcinoma 1.65 2 11002220 (2)
    cancer 1.04 12 8632481 (1), 18979636 (1), 10744660 (1), 16188273 (1) (see all 12)
    lupus erythematosus systemic 0 1 9826744 (1)
    leukemia 0 2 9621126 (1), 8016107 (1)

    Genetic Association Database (GAD): RNASE1
    Human Genome Epidemiology (HuGE) Navigator: RNASE1 (7 documents)

    Export disorders for RNASE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for RNASE1 gene, integrated from 10 sources (see all 378):
    (articles sorted by number of sources associating them with RNASE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location. (PubMed id 8588814)1, 2, 3 Kochetov A.V....Rivkin M.I. (Bioorg. Khim. 1995)
    2. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PubMed id 17350650)1, 2, 9 Johnson R.J....Raines R.T. (J. Mol. Biol. 2007)
    3. Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. (PubMed id 11021969)1, 2, 9 Pous J.... Coll M. (J. Mol. Biol. 2000)
    4. The additive effect of p53 Arg72Pro and RNASEL Arg462Gln genotypes on age of disease onset in Lynch syndrome patients with pathogenic germline mutations in MSH2 or MLH1. (PubMed id 17224235)1, 4 KrA1ger S....Schackert H.K. (Cancer Lett. 2007)
    5. Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant. (PubMed id 17234723)1, 4 Liu X....Witte J.S. (Carcinogenesis 2007)
    6. DNA variation in MSR1, RNASEL and E-cadherin genes and prostate cancer in Poland. (PubMed id 17627168)1, 4 Cybulski C....LubiA8ski J. (Urol. Int. 2007)
    7. Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma. (PubMed id 16114055)1, 4 Noonan-Wheeler F.C....Kibel A.S. (Prostate 2006)
    8. Duplication and divergence of two distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys. (PubMed id 16751256)1, 2 Schienman J.E.... Stewart C.B. (Mol. Biol. Evol. 2006)
    9. Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study. (PubMed id 16054567)1, 4 KrA1ger S....Schackert H.K. (Lancet Oncol. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 6035 HGNC: 10044 AceView: RNASE1 Ensembl:ENSG00000129538 euGenes: HUgn6035
    ECgene: RNASE1 H-InvDB: RNASE1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RNASE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RNASE1 gene:
    Search GeneIP for patents involving RNASE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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