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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RNASE1 Gene

protein-coding   GIFtS: 59
GCID: GC14M021269

ribonuclease, RNase A family, 1 (pancreatic)


(Previous symbol: RNS1)
 Explore 29 diseases affiliated with
RNASE1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RNASE1    

Aliases
for RNASE1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ribonuclease, RNase A Family, 1 (Pancreatic)1 2     RIB-12 3
RNS11 2 3 5     RIB12 3
Ribonuclease 12 3     RNase 12 3
Ribonuclease A2 3     RNase A2 3
RNase UpI-12 3     EC 3.1.27.53 8
HP-RNase2 3     Ribonuclease Pancreatic2

External Ids:    HGNC: 100441   Entrez Gene: 60352   Ensembl: ENSG000001295387   OMIM: 1804405   UniProtKB: P079983   

Export aliases for RNASE1 gene to outside databases

Previous GC identifers: GC14M018641 GC14M015056 GC14M019259 GC14M020339 GC14M001390


Summaries
for RNASE1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RNASE1:
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A
superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It
prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded
protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus
and four transcript variants encoding the same protein have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RNAS1_HUMAN, P07998
Function: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single
stranded and double stranded RNA

Gene Wiki entry for RNASE1


Genomic Views
for RNASE1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RNASE1 gene promoter:
         AREB6   ER-alpha   S8   COMP1   Lmo2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RNASE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RNASE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RNASE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.1

RNASE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RNASE1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021269:  view genomic region     (about GC identifiers)

Start:
 21,269,387 bp from pter      End:
 21,271,437 bp from pter
Size:
 2,051 bases      Orientation:
 minus strand

Proteins
for RNASE1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RNAS1_HUMAN, P07998 (See protein sequence)
Recommended Name: Ribonuclease pancreatic precursor  
Size: 156 amino acids; 17644 Da
Subunit: Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur.
Interaction with RNH1 inhibits this protein
Subcellular location: Secreted
6/11 PDB 3D structures from and Proteopedia for RNASE1 (see all 11):
1DZA (3D)        1E21 (3D)        1H8X (3D)        1Z7X (3D)        2E0J (3D)        2E0L (3D)    
Secondary accessions: B2R589 D3DS06 Q16830 Q16869 Q1KHR2 Q6ICS5 Q9UCB4 Q9UCB5

Explore the universe of human proteins at neXtProt for RNASE1: NX_P07998

Post-translational modifications:

  • N-linked glycans are of complex type1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07998

    • 4/13 DME Specific Peptides for RNASE1 (P07998) (see all 13)
     IIVACEG  CKPVNTF  RRNMTQG  MHITDCR 

    RNASE1 Protein expression data from MOPED and PaxDb:    About this image 
    RNASE1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_002924.1  NP_937875.1  NP_937877.1  NP_937878.1  

    ENSEMBL proteins: 
     ENSP00000381057   ENSP00000344193   ENSP00000399493   ENSP00000451058   ENSP00000381060  

    Human Recombinant Protein Products for RNASE1: 
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    Novus Biologicals RNASE1 Proteins
    Novus Biologicals RNASE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RNASE1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    RNASE1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for RNASE1

    Protein Domains /
    Families
    for RNASE1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RNASE1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR023411 RNaseA_AS
     IPR023412 RNaseA_domain
     IPR001427 RNaseA

    Graphical View of Domain Structure for InterPro Entry P07998

    ProtoNet protein and cluster: P07998

    1 Blocks protein family: IPB001427 Pancreatic ribonuclease

    UniProtKB/Swiss-Prot: RNAS1_HUMAN, P07998
    Similarity: Belongs to the pancreatic ribonuclease family


    Function
    for RNASE1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNAS1_HUMAN, P07998
    Function: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single
    stranded and double stranded RNA
    Catalytic activity: Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides ending in Cp or
    Up with 2',3'-cyclic phosphate intermediates

         Genatlas biochemistry entry for RNASE1:
    ribonuclease RNAse A family,1,secretory,pancreatic with a dimeric mutant selectively cytotoxic for malignant cells

         Enzyme Number (IUBMB): EC 3.1.27.51 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004522pancreatic ribonuclease activity IEA--
    GO:0005515protein binding IPI17350650
         
    RNASE1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for RNASE1 

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: RNASE1
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RNASE1 (see all 6)
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    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RNASE1


    Pathways & Interactions
    for RNASE1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RNASE1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for RNASE1 (P079981, 2, 3 ENSP000003441934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNH1P134891, 3, ENSP000003464024EBI-2823523,EBI-1237106 I2D: score=3 STRING: ENSP00000346402
    CANXP278243I2D: score=2 
    RELAENSP000003842734STRING: ENSP00000384273
    --Q91YW32MINT-7299594
    About this table

    Drugs & Compounds
    for RNASE1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RNASE1 for compounds           About GeneDecksing

    EMD Millipore small molecules for RNASE1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RNASE1

    10/28 DrugBank Compounds for RNASE1 (see all 28)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    GuanidineAminomethanamidine (see all 9)113-00-8target--8700871 7986344 17139284 16302208 17016423 10592235
    1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione-- --target--17139284 17016423 10592235
    1-(3-O-Phosphono-Beta-L-Arabinofuranosyl)Pyrimidine-2,4(1h,3h)-Dione-- --target--17139284 17016423 10592235
    2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate-- --target--17139284 17016423 10592235
    2'-Deoxyuridine 3'-Monophosphate-- --target--17139284 17016423 10592235
    2'-Monophosphoadenosine-5'-Diphosphate-- --target--17139284 17016423 10592235
    2-Methyl-2-Propanol-- --target--17139284 17016423 10592235
    3'-Phosphate-Adenosine-5'-Diphosphate-- --target--17139284 17016423 10592235
    3'-Uridinemonophosphate-- --target--17139284 17016423 10592235
    5-Amino-1h-Pyrimidine-2,4-Dione-- --target--17139284 17016423 10592235

    10/94 Novoseek chemical compound relationships for RNASE1 gene (see all 94)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine-2'-monophosphate 89.8 7 11746706 (1), 15210951 (1), 14729124 (1), 15245999 (1) (see all 7)
    2-cmp 80.8 8 12023520 (2), 17957392 (2), 14729124 (1), 8286064 (1)
    5'-diphosphoadenosine 3'-phosphate 80.2 1 10441122 (1)
    poly c 75.4 12 17416340 (3), 7756988 (2), 9481869 (1), 10336457 (1) (see all 7)
    3'-uridinemonophosphate 72.3 1 15670155 (1)
    poly u 70.5 9 9481869 (1), 8643340 (1), 10336457 (1), 9399152 (1) (see all 6)
    2',5'-adp 55.4 2 14573867 (2)
    uridine 53 3 8037446 (1), 14573867 (1), 11456753 (1)
    pyrimidine 51 7 9578571 (2), 8159680 (1), 9358156 (1), 9918722 (1) (see all 5)
    trna 50.8 7 1377751 (2), 1400510 (2), 7685766 (1), 9422763 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about RNASE1 / RNAS1 

    Transcripts
    for RNASE1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RNASE1 gene (4 alternative transcripts): 
    NM_002933.4  NM_198232.2  NM_198234.2  NM_198235.2  

    Unigene Cluster for RNASE1:

    Ribonuclease, RNase A family, 1 (pancreatic)
    Hs.78224  [show with all ESTs]
    Unigene Representative Sequence: CF595800
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397967(uc001vyi.3) ENST00000340900(uc001vyg.3 uc001vyh.3)
    ENST00000412779(uc001vyf.3) ENST00000555698 ENST00000397970

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: RNASE1
    OriGene siRNA: RNASE1
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    Clone
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    Additional cDNA sequence: 

    AK098375.1 AK129871.1 AK312100.1 BC005324.1 BC022882.1 CR450318.1 S79281.1 

    12 DOTS entries:

    DT.449353  DT.97854772  DT.91997790  DT.101985031  DT.100826933  DT.100826934  DT.92456205  DT.95267775 
    DT.120767275  DT.92411048  DT.120767280  DT.95267781 

    24/439 AceView cDNA sequences (see all 439):

    BP372956 BI834388 BM789491 CR593433 BM830687 AA487797 AA456601 AA953492 
    BP373045 AI674106 BI828465 AA921989 AI198824 BM789300 CA413889 NM_198234 
    AI679609 BG534431 BM769735 CB142758 R49965 CR600644 BM669071 NM_002933 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RNASE1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
    SP1:              -                                       
    SP2:              -     -                                 
    SP3:              -     -     -                           
    SP4:                                                      


    ECgene alternative splicing isoforms for RNASE1

    Expression
    for RNASE1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RNASE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAACCCCTC
    RNASE1 Expression
    About this image

    RNASE1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    Definitive endoderm-like cells (Generation of mesend...)
    Alveolar type II cells (Derivation of mature...)Lung

    See RNASE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RNASE1

    SOURCE GeneReport for Unigene cluster: Hs.78224

    UniProtKB/Swiss-Prot: RNAS1_HUMAN, P07998
    Tissue specificity: Pancreas and other tissues and body fluids (indicating it may have other physiological functions
    besides its role in digestion)

        SABiosciences Custom PCR Arrays for RNASE1
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    In Situ
    Assay Products:     
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    Orthologs
    for RNASE1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for RNASE1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RNL2_CHICK6
    RSFR_CHICK6
    		 Angiogenin
    		 33(a)
    30(a)
    		 many ↔ many
    many ↔ many
    		 4(51109366-51110407)
    6(10376970-10386988)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 3)    		 --
    		 40(a)
    29(a)
    (see all 3)    		 many ↔ many
    possible ortholog
    (see all 3)    		 GL343220.1(1531632-1532063)
    GL343220.1(1438299-1438661)
    zebrafish
    (Danio rerio)    		 Actinopterygii rnasel26
    rnasel36
    		 ribonuclease like 3
    		 32(a)
    29(a)
    		 many ↔ many
    many ↔ many
    		 22(6217650-6218836)
    14(40044381-40046544)


    ENSEMBL Gene Tree for RNASE1 (if available)
    TreeFam Gene Tree for RNASE1 (if available) 

    Paralogs
    for RNASE1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RNASE1 gene
    RNASE32  RNASE72  RNASE82  ANG2  RNASE62  RNASE42  RNASE22  ENSG000002588182  
    6 SIMAP similar genes for RNASE1 using alignment to 2 protein entries:     RNAS1_HUMAN (see all proteins):
    RNASE4    RNASE12    ANG    RNASE6    RNASE7    RNASE8

    RNASE1 for paralogs           About GeneDecksing



    Genomic Variants
    for RNASE1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/72 NCBI SNPs in RNASE1 are shown (see all 72)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1881916051,2
    		--21269044(+) TTCTGG/TCTCTA 4 -- ds50010--------
    rs735820011,2
    		C,F--21269171(+) CTTCCC/TCACCC 4 -- ds50014Minor allele frequency- T:0.15WA CSA 124
    rs1932648481,2
    		--21269303(+) CCCTTG/TTGTCT 4 -- ds50010--------
    rs740346091,2
    		C,F--21269503(+) CAGAAC/ACGCTT 4 -- ds50015Minor allele frequency- A:0.46WA CSA 127
    rs172543521,2
    		C,F,H--21269507(+) ACCGCT/CTCAGA 4 -- ds50018Minor allele frequency- C:0.03NA NS EA 668
    rs1118169051,2
    		C--21269514(+) CAGAAT/ATCAGG 4 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs1854259501,2
    		--21269525(+) TGTTTG/TCAACT 4 -- ut310--------
    rs740346101,2
    		C--21269612(+) GCAGGG/AATGGG 4 -- ut312Minor allele frequency- A:0.08WA 120
    rs1379348381,2
    		--21269629(+) GAAAGA/GGAAGC 4 -- ut310--------
    rs1895555441,2
    		--21269637(+) AGCATA/GTGTGT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for RNASE1 (21269387 - 21271437 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RNASE1
         1 CNV: 3930

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    Disorders / Diseases
    for RNASE1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RNASE1 for disorders           About GeneDecksing

    OMIM gene information: 180440    OMIM disorders: --

    20/29 diseases for RNASE1 (see all 29):    About MalaCards
    pancreatitis    osteogenesis imperfecta    osteogenesis imperfecta type iii    dna topoisomerase ii
    gyrate atrophy    malignant mesothelioma    amyotrophic lateral sclerosis    lateral sclerosis
    lupus erythematosus    lynch syndrome    acute lymphoblastic leukemia    lymphoblastic leukemia
    viral hepatitis    pancreatic carcinoma    pancreatic cancer    prostate cancer
    polyposis    carcinoma    leukemia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for RNASE1:
    T lymphocyte deficiency

    10/22 Novoseek disease relationships for RNASE1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteogenesis imperfecta 25.2 1 8444468 (1)
    malignant mesothelioma 20.1 2 16188273 (1), 16313179 (1)
    neovascularization 15.6 6 17916583 (1), 19354288 (1), 19173562 (1), 7874290 (1) (see all 5)
    immunodeficiency 10.2 4 2034672 (2), 1377751 (1), 8016107 (1)
    erythroleukemia 9.39 1 17350650 (1)
    asthma 1.81 1 19189375 (1)
    carcinoma 1.65 2 11002220 (2)
    cancer 1.04 12 8632481 (1), 18979636 (1), 10744660 (1), 16188273 (1) (see all 12)
    lupus erythematosus systemic 0 1 9826744 (1)
    leukemia 0 2 9621126 (1), 8016107 (1)

    Genetic Association Database (GAD): RNASE1
    Human Genome Epidemiology (HuGE) Navigator: RNASE1 (7 documents)

    Export disorders for RNASE1 gene to outside databases

    Publications
    for RNASE1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RNASE1 gene, integrated from 9 sources (see all 374):
    (articles sorted by number of sources associating them with RNASE1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location. (PubMed id 8588814)1, 2, 3 Kochetov A.V....Rivkin M.I. (1995)
    2. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PubMed id 17350650)1, 2, 9 Johnson R.J....Raines R.T. (2007)
    3. Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. (PubMed id 11021969)1, 2, 9 Pous J.... Coll M. (2000)
    4. Association of hereditary prostate cancer gene polymorphic variants with sporadic aggressive prostate carcinoma. (PubMed id 16114055)1, 4 Noonan-Wheeler F.C....Kibel A.S. (2006)
    5. Duplication and divergence of two distinct pancreatic ribnuclease genes in leaf-eating African and Asian colobine monkeys. (PubMed id 16751256)1, 2 Schienman J.E.... Stewart C.B. (2006)
    6. Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study. (PubMed id 16054567)1, 4 Kruger S....Schackert H.K. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Analysis of the RNASEL gene in familial and sporadic prostate cancer. (PubMed id 12022038)1, 4 Wang L....Thibodeau S.N. (2002)
    9. Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution. (PubMed id 11264578)1, 2 Pous J.... Coll M. (2001)
    10. The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization. (PubMed id 11591351)1, 2 Canals A....Coll M. (2001)

    External Searches for RNASE1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing RNASE1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6035 HGNC: 10044 AceView: RNASE1 Ensembl:ENSG00000129538 euGenes: HUgn6035
    ECgene: RNASE1 H-InvDB: RNASE1

    Other Databases showing RNASE1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RNASE1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RNASE1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for RNASE1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RNASE1 gene:
    Search GeneIP for patents involving RNASE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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