Aliases for RNASE1 Gene
External Ids for RNASE1 Gene
Previous HGNC Symbols for RNASE1 Gene
Previous GeneCards Identifiers for RNASE1 Gene
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNASE1 Gene
RNASE1 (Ribonuclease A Family Member 1, Pancreatic) is a Protein Coding gene. Diseases associated with RNASE1 include pancreatic cancer and st. louis encephalitis. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is ANG.
UniProtKB/Swiss-Prot for RNASE1 Gene
Endonuclease that catalyzes the cleavage of RNA on the 3 side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.