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Aliases for RNASE1 Gene

Aliases for RNASE1 Gene

  • Ribonuclease, RNase A Family, 1 (Pancreatic) 2 3
  • RNS1 3 4 6
  • Ribonuclease 1 3 4
  • RNase UpI-1 3 4
  • EC 3.1.27.5 4 63
  • HP-RNase 3 4
  • RNase 1 3 4
  • RNase A 3 4
  • RIB-1 3 4
  • RIB1 3 4
  • Ribonuclease Pancreatic 3
  • Ribonuclease A C1 3
  • Ribonuclease A 4
  • RAC1 3

External Ids for RNASE1 Gene

Previous Symbols for RNASE1 Gene

  • RNS1

Summaries for RNASE1 Gene

Entrez Gene Summary for RNASE1 Gene

  • This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNASE1 Gene

RNASE1 (Ribonuclease, RNase A Family, 1 (Pancreatic)) is a Protein Coding gene. Diseases associated with RNASE1 include osteogenesis imperfecta, type iii and osteogenesis imperfecta. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is ANG.

UniProtKB/Swiss-Prot for RNASE1 Gene

  • Endonuclease that catalyzes the cleavage of RNA on the 3 side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.

Gene Wiki entry for RNASE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE1 Gene

Genomics for RNASE1 Gene

Genomic Location for RNASE1 Gene

Start:
20,801,228 bp from pter
End:
20,803,278 bp from pter
Size:
2,051 bases
Orientation:
Minus strand

Genomic View for RNASE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RNASE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE1 Gene

Regulatory Elements for RNASE1 Gene

Proteins for RNASE1 Gene

  • Protein details for RNASE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07998-RNAS1_HUMAN
    Recommended name:
    Ribonuclease pancreatic
    Protein Accession:
    P07998
    Secondary Accessions:
    • B2R589
    • D3DS06
    • Q16830
    • Q16869
    • Q1KHR2
    • Q6ICS5
    • Q9UCB4
    • Q9UCB5

    Protein attributes for RNASE1 Gene

    Size:
    156 amino acids
    Molecular mass:
    17644 Da
    Quaternary structure:
    • Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein.

    Three dimensional structures from OCA and Proteopedia for RNASE1 Gene

neXtProt entry for RNASE1 Gene

Proteomics data for RNASE1 Gene at MOPED

Post-translational modifications for RNASE1 Gene

Other Protein References for RNASE1 Gene

Domains for RNASE1 Gene

Gene Families for RNASE1 Gene

HGNC:
  • RNASE :Ribonucleases, RNase A

Protein Domains for RNASE1 Gene

Suggested Antigen Peptide Sequences for RNASE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07998

UniProtKB/Swiss-Prot:

RNAS1_HUMAN
Family:
  • Belongs to the pancreatic ribonuclease family.:
    • P07998
genes like me logo Genes that share domains with RNASE1: view

Function for RNASE1 Gene

Molecular function for RNASE1 Gene

GENATLAS Biochemistry: ribonuclease RNAse A family,1,secretory,pancreatic with a dimeric mutant selectively cytotoxic for malignant cells
UniProtKB/Swiss-Prot CatalyticActivity: Endonucleolytic cleavage to nucleoside 3-phosphates and 3-phosphooligonucleotides ending in Cp or Up with 2,3-cyclic phosphate intermediates
UniProtKB/Swiss-Prot Function: Endonuclease that catalyzes the cleavage of RNA on the 3 side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.

Enzyme Numbers (IUBMB) for RNASE1 Gene

Gene Ontology (GO) - Molecular Function for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity --
GO:0004522 ribonuclease A activity IEA --
GO:0005515 protein binding IPI 17350650
genes like me logo Genes that share ontologies with RNASE1: view

miRNA for RNASE1 Gene

miRTarBase miRNAs that target RNASE1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RNASE1 Gene

Localization for RNASE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RNASE1 Gene COMPARTMENTS Subcellular localization image for RNASE1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
chloroplast 1
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RNASE1: view

Pathways for RNASE1 Gene

genes like me logo Genes that share pathways with RNASE1: view

Gene Ontology (GO) - Biological Process for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic TAS 8049276
genes like me logo Genes that share ontologies with RNASE1: view

Compounds for RNASE1 Gene

(94) Novoseek inferred chemical compound relationships for RNASE1 Gene

Compound -log(P) Hits PubMed IDs
cytidine-2-monophosphate 89.8 7
2-cmp 80.8 6
5-diphosphoadenosine 3-phosphate 80.2 1
poly c 75.4 10
3-uridinemonophosphate 72.3 1
genes like me logo Genes that share compounds with RNASE1: view

Transcripts for RNASE1 Gene

Unigene Clusters for RNASE1 Gene

Ribonuclease, RNase A family, 1 (pancreatic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for RNASE1 Gene

GeneLoc Exon Structure for
RNASE1
ECgene alternative splicing isoforms for
RNASE1

Expression for RNASE1 Gene

mRNA expression in normal human tissues for RNASE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE1 Gene

This gene is overexpressed in Pancreas (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RNASE1 Gene

SOURCE GeneReport for Unigene cluster for RNASE1 Gene Hs.78224

mRNA Expression by UniProt/SwissProt for RNASE1 Gene

P07998-RNAS1_HUMAN
Tissue specificity: Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion)
genes like me logo Genes that share expressions with RNASE1: view

Orthologs for RNASE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE1 35
  • 98.72 (n)
  • 98.08 (a)
RNASE1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRN 36
  • 65 (a)
OneToMany
RNASE1 35
  • 78.97 (n)
  • 71.54 (a)
RNASE1 36
  • 72 (a)
OneToMany
SRN 36
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC475395 35
  • 75.39 (n)
  • 67.79 (a)
RNASE1 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnase1 35
  • 81.06 (n)
  • 71.97 (a)
Rnase1 16
Rnase1 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 32 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Rnase1 35
  • 75 (n)
  • 65.91 (a)
chicken
(Gallus gallus)
Aves ANG 36
  • 29 (a)
ManyToMany
CL2 36
  • 31 (a)
ManyToMany
RSFR 36
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 41 (a)
ManyToMany
Species with no ortholog for RNASE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE1 Gene

ENSEMBL:
Gene Tree for RNASE1 (if available)
TreeFam:
Gene Tree for RNASE1 (if available)

Paralogs for RNASE1 Gene

Paralogs for RNASE1 Gene

Selected SIMAP similar genes for RNASE1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE1: view

Variants for RNASE1 Gene

Sequence variations from dbSNP and Humsavar for RNASE1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs13487 -- 20,801,418(+) CCACC(A/T)CACAA utr-variant-3-prime
rs1804214 -- 20,801,517(-) CTGTG(A/G)AAGAA utr-variant-3-prime
rs1804215 -- 20,801,869(-) GGGGC(G/T)GTGCA reference, missense
rs1804216 -- 20,801,550(-) CTCCA(A/C)AGCTG utr-variant-3-prime
rs1804217 -- 20,801,509(-) GAAGT(A/T)ACTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RNASE1 Gene

Variant ID Type Subtype PubMed ID
dgv607e1 CNV Complex 17122850
nsv428293 CNV Gain+Loss 18775914

Relevant External Links for RNASE1 Gene

HapMap Linkage Disequilibrium report
RNASE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE1 Gene

Disorders for RNASE1 Gene

(1) University of Copenhagen DISEASES for RNASE1 Gene

(22) Novoseek inferred disease relationships for RNASE1 Gene

Disease -log(P) Hits PubMed IDs
osteogenesis imperfecta 25.2 1
malignant mesothelioma 20.1 2
neovascularization 15.6 5
immunodeficiency 10.2 4
erythroleukemia 9.39 1

Relevant External Links for RNASE1

Genetic Association Database (GAD)
RNASE1
Human Genome Epidemiology (HuGE) Navigator
RNASE1
genes like me logo Genes that share disorders with RNASE1: view

No data available for UniProtKB/Swiss-Prot for RNASE1 Gene

Publications for RNASE1 Gene

  1. Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. (PMID: 11021969) Pous J. … Coll M. (J. Mol. Biol. 2000) 3 4 23
  2. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PMID: 17350650) Johnson R.J. … Raines R.T. (J. Mol. Biol. 2007) 3 4 23
  3. Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location. (PMID: 8588814) Kochetov A.V. … Rivkin M.I. (Bioorg. Khim. 1995) 2 3 4
  4. Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease. (PMID: 7649283) Russo N. … D'Alessio G. (FEBS Lett. 1995) 3 4
  5. Nucleotide sequence encoding human pancreatic ribonuclease. (PMID: 8049276) Seno M. … Yamada H. (Biochim. Biophys. Acta 1994) 3 4

Products for RNASE1 Gene

Sources for RNASE1 Gene

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