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Aliases for RN7SL1 Gene

Subcategory (RNA class) for RN7SL1 Gene


Quality Score for this RNA gene is


Aliases for RN7SL1 Gene

  • RNA, 7SL, Cytoplasmic 1 2 3 5
  • RNA, 7SL, Cytoplasmic 2
  • RNSRP1 3
  • RN7SL 3
  • 7L1a 3
  • 7SL 3

External Ids for RN7SL1 Gene

ORGUL Members for RN7SL1 Gene

Previous HGNC Symbols for RN7SL1 Gene

  • RN7SL

Previous GeneCards Identifiers for RN7SL1 Gene

  • GC00U911064
  • GC14U900430
  • GC14P049126
  • GC14P050053
  • GC14P049588
  • GC14P049590
  • GC14P049595

Summaries for RN7SL1 Gene

Entrez Gene Summary for RN7SL1 Gene

  • The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL1, that is partially homologous to Alu DNA (Ullu and Weiner, 1984 [PubMed 6084597]).[supplied by OMIM, Jul 2008]

GeneCards Summary for RN7SL1 Gene

RN7SL1 (RNA, 7SL, Cytoplasmic 1) is an RNA Gene, and is affiliated with the SRP RNA class. Diseases associated with RN7SL1 include Perlman Syndrome.

Gene Wiki entry for RN7SL1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RN7SL1 Gene

Genomics for RN7SL1 Gene

Regulatory Elements for RN7SL1 Gene

Promoters for RN7SL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001456973 -480 3001 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 ZNF143

Genomic Location for RN7SL1 Gene

49,586,580 bp from pter
49,586,878 bp from pter
299 bases
Plus strand

Genomic View for RN7SL1 Gene

Genes around RN7SL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RN7SL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RN7SL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RN7SL1 Gene

Proteins for RN7SL1 Gene

Post-translational modifications for RN7SL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RN7SL1 Gene

Domains & Families for RN7SL1 Gene

Gene Families for RN7SL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RN7SL1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RN7SL1 Gene

Function for RN7SL1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RN7SL1 Gene

Localization for RN7SL1 Gene

Subcellular locations from

Jensen Localization Image for RN7SL1 Gene COMPARTMENTS Subcellular localization image for RN7SL1 gene
Compartment Confidence
endoplasmic reticulum 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RN7SL1 Gene

Pathways & Interactions for RN7SL1 Gene

SuperPathways for RN7SL1 Gene

No Data Available

Interacting Proteins for RN7SL1 Gene

Gene Ontology (GO) - Biological Process for RN7SL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RN7SL1 Gene

Transcripts for RN7SL1 Gene

mRNA/cDNA for RN7SL1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RN7SL1 Gene

No ASD Table

Relevant External Links for RN7SL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RN7SL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RN7SL1 Gene

mRNA differential expression in normal tissues according to GTEx for RN7SL1 Gene

This gene is overexpressed in Whole Blood (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of RN7SL1 Gene:

genes like me logo Genes that share expression patterns with RN7SL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RN7SL1 Gene

Orthologs for RN7SL1 Gene

Evolution for RN7SL1 Gene

Gene Tree for RN7SL1 (if available)
Gene Tree for RN7SL1 (if available)

No data available for Orthologs for RN7SL1 Gene

Paralogs for RN7SL1 Gene

No data available for Paralogs for RN7SL1 Gene

Variants for RN7SL1 Gene

Sequence variations from dbSNP and Humsavar for RN7SL1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs587777568 Pathogenic 49,586,021(+) CCGGA(A/T)CAGAC upstream-variant-2KB, reference, missense
rs587777569 Pathogenic 49,585,963(+) AACCG(A/G)TATCC upstream-variant-2KB, reference, missense
rs10139832 -- 49,584,778(+) AAAAA(A/T)TTACA intron-variant, upstream-variant-2KB
rs10150624 -- 49,584,847(+) ATCTC(A/G)AAGAG intron-variant, upstream-variant-2KB
rs10150823 -- 49,585,033(+) CTTTC(C/T)GGCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RN7SL1 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV gain+loss 19812545
nsv977464 CNV duplication 23825009

Relevant External Links for RN7SL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RN7SL1 Gene

Disorders for RN7SL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RN7SL1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
perlman syndrome
  • nephroblastomatosis - fetal ascites - macrosomia - wilms tumor
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with RN7SL1: view

No data available for UniProtKB/Swiss-Prot , Genatlas and External Links for RN7SL1 Gene

Publications for RN7SL1 Gene

  1. Novel upstream and intragenic control elements for the RNA polymerase III-dependent transcription of human 7SL RNA genes. (PMID: 15667936) Englert M. … Beier H. (Biochimie 2004) 2 3 64
  2. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PMID: 12244299) Kuglstatter A. … Nagai K. (Nat. Struct. Biol. 2002) 3 22 64
  3. Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. (PMID: 6084597) Ullu E. … Weiner A.M. (EMBO J. 1984) 2 3 64
  4. Tumor FOXP3 represses the expression of long noncoding RNA 7SL. (PMID: 26718402) Yang Y. … Shan C. (Biochem. Biophys. Res. Commun. 2016) 3 64
  5. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. (PMID: 23221635) Piazzon N. … Massenet S. (Nucleic Acids Res. 2013) 3 64

Products for RN7SL1 Gene

Sources for RN7SL1 Gene

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