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RN7SL1 Gene

RNA gene   GIFtS: 17
GCID: GC14P050053

RNA, 7SL, Cytoplasmic 1

(Previous names: RNA, 7SL, cytoplasmic)
(Previous symbol: RN7SL)
Pneumococci & Pneumococcal Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): SRP

Quality score for this RNA gene is 5

Aliases
RNA, 7SL, Cytoplasmic 11 2     7L1a2
RN7SL1 2     RNSRP12
7SL2 5     7L1A5
RNA, 7SL, Cytoplasmic1     

External Ids:    HGNC: 100381   Entrez Gene: 60292   Ensembl: ENSG000002584867   OMIM: 6121775   
ORGUL members:    fRNAdb10:FR203166 FR194407 FR216157 FR203166 FR194407      
NCBI13:X01037 X04248 X01037 X04248 AB061847 see all 6    
NONCODE14:u4690    
Rfam:RF00017    

Export aliases for RN7SL1 gene to outside databases

Previous GC identifers: GC00U911064 GC14U900430 GC14P049126


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RN7SL1 Gene:
The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational
insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides
(e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL1, that is partially homologous to Alu DNA (Ullu
and Weiner, 1984 (PubMed 6084597)).(supplied by OMIM, Jul 2008)

GeneCards Summary for RN7SL1 Gene:
RN7SL1 (RNA, 7SL, cytoplasmic 1) is an RNA gene, and is affiliated with the SRP RNA class. Diseases associated with RN7SL1 include hiv-1.

Gene Wiki entry for RN7SL1 (Signal recognition particle RNA) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RN7SL1 gene promoter:
         c-Fos   ER-alpha   Bach1   AP-1   Nkx2-5   POU2F1   FOXO4   POU2F1a   c-Jun   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RN7SL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.3   Ensembl cytogenetic band:  14q21.3   HGNC cytogenetic band: 14q21.3

RN7SL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RN7SL1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P050053:  view genomic region     (about GC identifiers)

Start:
50,053,297 bp from pter      End:
50,053,596 bp from pter
Size:
300 bases      Orientation:
plus strand

1 alternative location:
Chr7-,CRA_TCAG 74,156,369-74,223,197     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RN7SL1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
scRNA: ncRNAs / Small cytoplasmic RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RN7SL1
Interactions:

    GeneGlobe Interaction Network for RN7SL1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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3 fRNAdb Secondary structures:


2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000553637(antisense) ENST00000580625(antisense)

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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for RN7SL1:none

RN7SL1 expression in normal human tissues (normalized intensities)      RN7SL1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
RN7SL1 Expression
About this image


RN7SL1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Endoderm (Gastrulation Derivatives)
         Endoderm-like cells
RN7SL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

ENSEMBL Gene Tree for RN7SL1 (if available)
TreeFam Gene Tree for RN7SL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing RN7SL1
DNA2.0 Custom Variant and Variant Library Synthesis for RN7SL1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612177    OMIM disorders: --

1 disease for RN7SL1:    About MalaCards
hiv-1


RN7SL1 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Export disorders for RN7SL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for RN7SL1 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with RN7SL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Novel upstream and intragenic control elements for the RNA polymerase III-dependent transcription of human 7SL RNA genes. (PubMed id 15667936)1, 3 Englert M....Beier H. (Biochimie 2004)
  2. Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. (PubMed id 6084597)1, 3 Ullu E. and Weiner A.M. (EMBO J. 1984)
  3. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PubMed id 12244299)1, 9 Kuglstatter A.... Nagai K. (Nat. Struct. Biol. 2002)
  4. Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (Nucleic Acids Res. 2013)
  5. Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging. (PubMed id 18067920)1 Wang T....Yu X.F. (J. Mol. Biol. 2008)
  6. 7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. (PubMed id 17881443)1 Wang T....Yu X.F. (J. Virol. 2007)
  7. Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle. (PubMed id 12086622)1 Oubridge C....Nagai K. (Mol. Cell 2002)
  8. 7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles. (PubMed id 16489186)9 Onafuwa-Nuga A.A....King S.R. (RNA 2006)
  9. Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles. (PubMed id 17959647)9 Tian C....Yu X.F. (Nucleic Acids Res. 2007)
  10. Heterodimer SRP9/14 is an integral part of the neural BC200 RNP in primate brain. (PubMed id 9605471)9 Kremerskothen J....Brosius J. (Neurosci. Lett. 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6029 HGNC: 10038 Ensembl:ENSG00000258486 euGenes: HUgn6029 ECgene: RN7SL1
H-InvDB: RN7SL1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for RN7SL1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for RN7SL1 gene:
Search GeneIP for patents involving RN7SL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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