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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RN7SL1 Gene

RNA gene GIFtS: 19
GCID: GC14P050053

RNA, 7SL, cytoplasmic 1

(Previous names: RNA, 7SL, cytoplasmic )
(Previous symbol: RN7SL)

Search for RN7SL1
in

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Subcategory (RNA class): SRP

Quality score for this RNA gene is 5

Aliases
RNA, 7SL, Cytoplasmic 1¹ ²		RNSRP1¹ ²
7SL¹ ² ⁵		RNA, 7SL, Cytoplasmic¹
7L1a¹ ²		7L1A⁵
RN7SL¹ ²

External Ids:	HGNC: 10038¹	Entrez Gene: 6029²	Ensembl: ENSG00000258486⁷	OMIM: 612177⁵

ORGUL members:	fRNAdb¹⁰:FR203166 FR194407 FR194407 FR203166 FR216157
	NCBI:X01037 X04248 AB061847 AL139099 X04248	see all 6
	NONCODE:u4690 n343030
	Rfam:RF00017

Export aliases for RN7SL1 gene to outside databases

Previous GC identifers: GC00U911064 GC14U900430 GC14P049126

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RN7SL1:

The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational

insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g.,

SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL1, that is partially homologous to Alu DNA (Ullu and Weiner,

1984 (PubMed 6084597)).(supplied by OMIM, Jul 2008)

Gene Wiki entry for RN7SL1 (Signal recognition particle RNA)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RN7SL1 gene promoter:
c-Fos ER-alpha Bach1 AP-1 Nkx2-5 POU2F1 FOXO4 POU2F1a c-Jun
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RN7SL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.3 Ensembl cytogenetic band: 14q21.3 HGNC cytogenetic band: 14q22.1

RN7SL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RN7SL1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P050053: view genomic region (about GC identifiers)

Start:	50,053,297 bp from pter	End:	50,053,596 bp from pter
Size:	300 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

n343030
FR0216157
FR0194407
FR0203166

SRP
Full Legend

50053296 50053446 50053596 chr14

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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UniProtKB: --

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
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Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RN7SL1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

3 fRNAdb Secondary structures:

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000553637(uc021rsp.1)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for RN7SL1:none

RN7SL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RN7SL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

SABiosciences Custom PCR Arrays for RN7SL1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for RN7SL1 (if available)
TreeFam Gene Tree for RN7SL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184688792^1,2		--	50051343(+)	`CGGGCA/GTGGTG`	3	--	int¹ us2k¹		0	--	--	--	--
rs142858551^1,2		--	50051377(+)	`CTAGGA/GAGGCT`	3	--	us2k¹ int¹		0	--	--	--	--
rs71291805^1,2	C,	--	50051420(+)	`AGGCT-/ACAGTGA`	3	--	int¹ us2k¹		1		NA	2
rs190321267^1,2		--	50051434(+)	`GAGATC/TACGCC`	3	--	us2k¹ int¹		0	--	--	--	--
rs181473828^1,2		--	50051472(+)	`GAGACA/CCAATT`	3	--	us2k¹ int¹		0	--	--	--	--
rs201451612^1,2		--	50051484(+)	`AAAAC-/AAAAAA`	3	--	int¹ us2k¹		0	--	--	--	--
rs10139832^1,2	C,F,A,H,	--	50051496(+)	`aaaaaT/ATTACA`	3	--	int¹ us2k¹		8		NS EA NA CSA	383
rs36101486^1,2	C,F,	--	50051496(+)	`AAATTT/-ACATC`	3	--	int¹ us2k¹		3		NA	6
rs185724908^1,2		--	50051528(+)	`CAATAC/GAAAAT`	3	--	us2k¹ int¹		0	--	--	--	--
rs10150624^1,2	C,F,A,	--	50051565(+)	`ATCTCG/AAAGAG`	3	--	int¹ us2k¹		16		NA WA CSA EA	696

HapMap Linkage Disequilibrium report for RN7SL1 (50053297 - 50053596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RN7SL1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RN7SL1 for disorders About MalaCards

RN7SL1 for disorders About GeneDecksing

OMIM gene information: 612177 OMIM disorders: --

Export disorders for RN7SL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RN7SL1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with RN7SL1)

Utopia: connect your pdf to the dynamic
world of online information

Novel upstream and intragenic control elements for the RNA polymerase III-dependent transcription of human 7SL RNA genes. (PubMed id 15667936)^{1, 3} Englert M....Beier H. (2004)
Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. (PubMed id 6084597)^{1, 3} Ullu E. and Weiner A.M. (1984)
Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PubMed id 12244299)^{1, 9} Kuglstatter A.... Nagai K. (2002)
Interaction with 7SL RNA but not with HIV-1 genomic RNA or P bodies is required for APOBEC3F virion packaging. (PubMed id 18067920)¹ Wang T....Yu X.F. (2008)
7SL RNA mediates virion packaging of the antiviral cytidine deaminase APOBEC3G. (PubMed id 17881443)¹ Wang T....Yu X.F. (2007)
Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle. (PubMed id 12086622)¹ Oubridge C....Nagai K. (2002)
7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles. (PubMed id 16489186)⁹ Onafuwa-Nuga A.A....King S.R. (2006)
Virion packaging determinants and reverse transcription of SRP RNA in HIV-1 particles. (PubMed id 17959647)⁹ Tian C....Yu X.F. (2007)
Heterodimer SRP9/14 is an integral part of the neural BC200 RNP in primate brain. (PubMed id 9605471)⁹ Kremerskothen J....Brosius J. (1998)
(PubMed id 11839493)¹⁰

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6029	HGNC: 10038	Ensembl:ENSG00000258486	euGenes: HUgn6029	ECgene: RN7SL1
H-InvDB: RN7SL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RN7SL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RN7SL1 gene
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GeneCards and IP:
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RNA, 7SL, cytoplasmic 1

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RN7SL1 Gene

RNA, 7SL, cytoplasmic 1

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