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Aliases for RN7SKP115 Gene

Subcategory (RNA class) for RN7SKP115 Gene

7SK RNA

Aliases for RN7SKP115 Gene

  • RNA, 7SK Small Nuclear Pseudogene 115 2 3 5

External Ids for RN7SKP115 Gene

Previous GeneCards Identifiers for RN7SKP115 Gene

  • GC11P100712

Summaries for RN7SKP115 Gene

GeneCards Summary for RN7SKP115 Gene

RN7SKP115 (RNA, 7SK Small Nuclear Pseudogene 115) is a Pseudogene, and is affiliated with the 7SK RNA class.

fRNAdb sequence ontologies for RN7SKP115 Gene - the ORGUL cluster for this gene includes several descriptions:

  • snRNA: A small nuclear RNA molecule involved in pre-mRNA splicing and processing.

  • 7SK RNA: 7SK was discovered as an abundant small nuclear RNA in the mid-70s but a possible function has only recently been suggested [1]. Two independent studies have found that 7SK RNA binds the CDK9/cyclin T complex (known as elongation factor P-TEFb). P-TEFb activates transcription by phosphorylating the C-terminal domain of RNA polymerase II. This process is negatively regulated by the 7SK RNP. The secondary structure of 7SK RNA shown here was proposed by Wasserman and Steitz on the basis of chemical modification and enzymatic cleavage experiments [2]. This family contains a number of annotated pseudogenes and 7SK derived repeats. The threshold is artificially high to minimise the pseudogene count.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RN7SKP115 Gene

Genomics for RN7SKP115 Gene

Regulatory Elements for RN7SKP115 Gene

Enhancers for RN7SKP115 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G100848 1.1 Ensembl ENCODE 0.4 +9.9 9919 2.5 ZSCAN4 FEZF1 RAD21 YY1 GATA2 FOS NR2F2 MAFF PRDM6 SMARCA4 RN7SKP115 GC11P100865
GH11G100830 1 Ensembl ENCODE 0.4 -7.9 -7912 2.9 BHLHE40 MAX ZEB2 RAD21 YY1 OSR2 ATF3 ZSCAN5C ZNF629 SCRT2 RN7SKP115 LOC100128386
GH11G100827 1 Ensembl ENCODE 0.4 -11.4 -11368 1.6 ELF3 SOX13 CTCF FOXA2 TEAD4 ZIC2 RAD21 TEAD3 ZNF143 SMC3 ARHGAP42 LOC100128386 RN7SKP115
GH11G100862 1.2 Ensembl ENCODE 0.3 +23.6 23617 1.7 HDAC1 CBX3 ZBTB40 RAD21 CHAMP1 TCF12 GATA2 CREM IKZF2 ZBTB2 GC11P100865 RN7SKP115
GH11G100808 1.2 Ensembl ENCODE 0.3 -30.2 -30226 1.2 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 FOS JUNB NCOA1 MBD2 ENSG00000255504 RN7SKP115 LOC100128386
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RN7SKP115 on UCSC Golden Path with GeneCards custom track

Genomic Location for RN7SKP115 Gene

Chromosome:
11
Start:
100,839,630 bp from pter
End:
100,839,946 bp from pter
Size:
317 bases
Orientation:
Plus strand

Genomic View for RN7SKP115 Gene

Genes around RN7SKP115 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RN7SKP115 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RN7SKP115 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RN7SKP115 Gene

ORGUL Member Location for RN7SKP115 Gene

ORGUL Member Location for RN7SKP115 gene

Proteins for RN7SKP115 Gene

Post-translational modifications for RN7SKP115 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RN7SKP115 Gene

Domains & Families for RN7SKP115 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RN7SKP115 Gene

Function for RN7SKP115 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RN7SKP115 Gene

Localization for RN7SKP115 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RN7SKP115 Gene

Pathways & Interactions for RN7SKP115 Gene

SuperPathways for RN7SKP115 Gene

No Data Available

Interacting Proteins for RN7SKP115 Gene

Gene Ontology (GO) - Biological Process for RN7SKP115 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RN7SKP115 Gene

Transcripts for RN7SKP115 Gene

mRNA/cDNA for RN7SKP115 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RN7SKP115 Gene

No ASD Table

Relevant External Links for RN7SKP115 Gene

GeneLoc Exon Structure for
RN7SKP115
ECgene alternative splicing isoforms for
RN7SKP115

Expression for RN7SKP115 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RN7SKP115 Gene

NURSA nuclear receptor signaling pathways regulating expression of RN7SKP115 Gene:

RN7SKP115
genes like me logo Genes that share expression patterns with RN7SKP115: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RN7SKP115 Gene

Orthologs for RN7SKP115 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RN7SKP115 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia 7SK 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm23539 35
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia 7SK 35
  • 59 (a)
ManyToMany
Species where no ortholog for RN7SKP115 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RN7SKP115 Gene

ENSEMBL:
Gene Tree for RN7SKP115 (if available)
TreeFam:
Gene Tree for RN7SKP115 (if available)

Paralogs for RN7SKP115 Gene

No data available for Paralogs for RN7SKP115 Gene

Variants for RN7SKP115 Gene

Relevant External Links for RN7SKP115 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RN7SKP115

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RN7SKP115 Gene

Disorders for RN7SKP115 Gene

No disorders were found for RN7SKP115 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RN7SKP115 Gene

Publications for RN7SKP115 Gene

  1. Transcription: surprising role for an elusive small nuclear RNA. (PMID: 11864590) Blencowe B.J. (Curr. Biol. 2002) 1
  2. Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function. (PMID: 1646389) Wassarman D.A. … Steitz J.A. (Mol. Cell. Biol. 1991) 1

Products for RN7SKP115 Gene

Sources for RN7SKP115 Gene

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