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Aliases for RN7SK Gene

Subcategory (RNA class) for RN7SK Gene

7SK RNA

Quality Score for this RNA gene is

13

Aliases for RN7SK Gene

  • RNA, 7SK Small Nuclear 2 3
  • RNA, 7SK, Nuclear 2 3
  • 7SK 3 6
  • 7SK Small Nuclear RNA 3

External Ids for RN7SK Gene

ORGUL Members for RN7SK Gene

Previous GeneCards Identifiers for RN7SK Gene

  • GC06U990106
  • GC06P052907
  • GC06P052968
  • GC06P052860
  • GC06P052691

Summaries for RN7SK Gene

GeneCards Summary for RN7SK Gene

RN7SK (RNA, 7SK Small Nuclear) is an RNA Gene, and is affiliated with the 7SK RNA class. Diseases associated with RN7SK include hiv-1.

Gene Wiki entry for RN7SK Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RN7SK Gene

Genomics for RN7SK Gene

Regulatory Elements for RN7SK Gene

Genomic Location for RN7SK Gene

Start:
52,995,620 bp from pter
End:
52,995,951 bp from pter
Size:
332 bases
Orientation:
Plus strand

Genomic View for RN7SK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RN7SK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RN7SK Gene

Proteins for RN7SK Gene

Post-translational modifications for RN7SK Gene

No Post-translational modifications

No data available for DME Specific Peptides for RN7SK Gene

Domains for RN7SK Gene

Gene Families for RN7SK Gene

HGNC:
  • snRNA :ncRNAs / Small nuclear RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RN7SK: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RN7SK Gene

Function for RN7SK Gene

Molecular function for RN7SK Gene

GENATLAS Biochemistry: small nuclear RNA,7SK

miRNA for RN7SK Gene

miRTarBase miRNAs that target RN7SK

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RN7SK Gene

Localization for RN7SK Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for RN7SK Gene

Pathways for RN7SK Gene

SuperPathways for RN7SK Gene

No Data Available

Interacting Proteins for RN7SK Gene

Gene Ontology (GO) - Biological Process for RN7SK Gene

None

No data available for Pathways by source for RN7SK Gene

Transcripts for RN7SK Gene

mRNA/cDNA for RN7SK Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RN7SK

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RN7SK Gene

No ASD Table

Relevant External Links for RN7SK Gene

GeneLoc Exon Structure for
RN7SK
ECgene alternative splicing isoforms for
RN7SK

Expression for RN7SK Gene

mRNA expression in normal human tissues for RN7SK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RN7SK Gene

This gene is overexpressed in Kidney - Cortex (5.1).
genes like me logo Genes that share expressions with RN7SK: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for RN7SK Gene

Orthologs for RN7SK Gene

This gene was present in the common ancestor of chordates.

Orthologs for RN7SK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia 7SK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia 7SK 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia 7SK 36
  • 99 (a)
OneToMany
7SK 36
  • 99 (a)
OneToMany
7SK 36
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rn7sk 16
Rn7sk 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia 7SK 36
  • 98 (a)
ManyToMany
chicken
(Gallus gallus)
Aves 7SK 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia 7SK 36
  • 91 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii rn7sk 36
  • 91 (a)
OneToMany
Species with no ortholog for RN7SK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RN7SK Gene

ENSEMBL:
Gene Tree for RN7SK (if available)
TreeFam:
Gene Tree for RN7SK (if available)

Paralogs for RN7SK Gene

No data available for Paralogs for RN7SK Gene

Variants for RN7SK Gene

Relevant External Links for RN7SK Gene

HapMap Linkage Disequilibrium report
RN7SK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for RN7SK Gene

Disorders for RN7SK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RN7SK Gene including...

Search for RN7SK Gene in MalaCards »

(1) Novoseek inferred disease relationships for RN7SK Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 18.1 1
genes like me logo Genes that share disorders with RN7SK: view

No data available for UniProtKB/Swiss-Prot for RN7SK Gene

Publications for RN7SK Gene

  1. 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. (PMID: 11713533) Nguyen V.T. … Bensaude O. (Nature 2001) 3 23
  2. Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. (PMID: 14580347) Yik J.H.N. … Zhou Q. (Mol. Cell 2003) 3 23
  3. Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA. (PMID: 14627702) Chen R. … Zhou Q. (J. Biol. Chem. 2004) 3 23
  4. A human immunodeficiency virus type 1 Tat-like arginine-rich RNA- binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. (PMID: 15169877) Yik J.H.N. … Zhou Q. (Mol. Cell. Biol. 2004) 3 23
  5. Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. (PMID: 16109377) Yang Z. … Zhou Q. (Mol. Cell 2005) 3 23

Products for RN7SK Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate RN7SK
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RN7SK
    • Block miRNA regulation of RN7SK using miScript Target Protectors

    Sources for RN7SK Gene

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