|
|
RNA, 7SK small nuclear(Previous names: RNA, 7SK, nuclear )
| |
Aliases
for RN7SK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): 7SK RNA
Quality score for this RNA gene is 6
| Aliases |
|---|
| RNA, 7SK Small Nuclear1 2 | | 7SK1 2 5 | | RNA, 7SK, Nuclear1 |
| External Ids: | HGNC: 100371 | Entrez Gene: 1250502 | Ensembl: ENSG000002021987 | OMIM: 6065155 |
Export aliases for RN7SK gene to outside databasesPrevious GC identifers: GC06U990106 GC06P052907 GC06P052968 GC06P052691
|---|
Summaries
for RN7SK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for RN7SK (7SK RNA)
fRNAdb sequence ontology for RN7SK:
snRNA - A small nuclear RNA molecule involved in pre-mRNA splicing and processing.
View fRNAdb secondary structures for RN7SK |
Genomic Views
for RN7SK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RN7SK gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B2 oct-B3 POU2F2 POU2F2C HEN1 POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for RN7SK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RN7SK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p12.2 Ensembl cytogenetic band: 6p12.2 HGNC cytogenetic band: 6p12.1RN7SK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P052860: view genomic region
(about GC identifiers)
Start:
|
52,860,418 bp from pter |
End:
|
52,860,749 bp from pter |
Size:
|
332 bases |
Orientation:
|
plus strand |
|
Proteins
for RN7SK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for RN7SK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for RN7SK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for RN7SK:small nuclear RNA,7SK
|
Pathways & Interactions
for RN7SK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RN7SK
|
Drugs & Compounds
for RN7SK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RN7SK
Search CenterWatch for drugs/clinical trials and news about RN7SK 
|
Transcripts
for RN7SK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
| 3 fRNAdb Secondary structures:
  
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000365328(misc_RNA)
24/71 AceView cDNA sequences (see all 71): AI655710 AI825755 BF475685 AI972281 AA559939 AI654949 BE503281 AA828594 X04236 AI350499 NR_001445 BE073960 AW593405 BF992614 BE073961 BE073962 BG223218 T57040 AV762045 AW270601 AA558345 CB046250 AA654640 BG222255
GeneLoc Exon Structure
|
Expression
for RN7SK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for RN7SK:RNAdb
RN7SK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for RN7SK
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RN7SK | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RN7SK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RN7SK |
Orthologs
for RN7SK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for RN7SK gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Rn7sk5 |
RNA, 7SK, nuclear |
-- |
|
9 (43.63 cM) 78175303 |
ENSEMBL Gene Tree for RN7SK (if available)
TreeFam Gene Tree for RN7SK (if available) |
Paralogs
for RN7SK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RN7SK gene
- ENSG000002223972 ENSG000002227042 ENSG000002520362 ENSG000002012872 ENSG000002015102 ENSG000002232022 ENSG000002023442 ENSG000002019122
- ENSG000002527302 ENSG000002015812 ENSG000002227642 ENSG000001998312 RN7SKP12 ENSG000002520512 ENSG000002225672 ENSG000002529632
- ENSG000002227742 ENSG000002523602 ENSG000002001312 ENSG000002224962 RN7SKP42 ENSG000002010272 ENSG000002224482 ENSG000002233242
- ENSG000002232732 ENSG000002229312 ENSG000002528372 ENSG000002016122 ENSG000002230062 ENSG000002222102 ENSG000002008672 ENSG000002517512
- ENSG000002227832 ENSG000002530572 ENSG000002222592 RN7SKP62 ENSG000002388752 ENSG000002224132 ENSG000002228802 ENSG000002222202
- ENSG000002024732 ENSG000002017822 ENSG000002014282 ENSG000002232812 ENSG000002528862 ENSG000002224602 ENSG000002229872 RN7SKP52
- ENSG000002522572 ENSG000002520762 ENSG000002529822 ENSG000002010102 ENSG000002519832 ENSG000002229462 ENSG000001993192 ENSG000002226162
- ENSG000002517322 ENSG000002006742 ENSG000002227212 ENSG000002003122 ENSG000002017942 ENSG000002519352 ENSG000001996402 ENSG000002224512
- ENSG000001994752 ENSG000002226782 ENSG000002225832 RN7SKP32 ENSG000002523962 ENSG000002527112 ENSG000002530062 ENSG000001999752
- ENSG000002523582 ENSG000001998762 ENSG000002220782 ENSG000002527972 ENSG000002524842 ENSG000002230072 ENSG000001996832 ENSG000002015642
- ENSG000002226172 ENSG000002529602 ENSG000002223752 ENSG000002229342 ENSG000002228742 ENSG000002229502 ENSG000002527572 ENSG000002229792
- ENSG000002016402 ENSG000002526562 ENSG000002007182 ENSG000002231742 ENSG000002231282 ENSG000002012012 ENSG000002517592 ENSG000002231452
- ENSG000002225432 ENSG000002226852 ENSG000002518272 ENSG000002227142 ENSG000002229422 ENSG000002528142 ENSG000002227442 ENSG000002519762
- ENSG000002008302 ENSG000002223522 ENSG000002017582 ENSG000002000572 ENSG000002231902 ENSG000002231682 ENSG000002014962 ENSG000002530192
- ENSG000002227552 ENSG000002526972 ENSG000002519472 ENSG000001992182 ENSG000002227842 ENSG000002518142 ENSG000001996912 ENSG000002000912
- ENSG000002224992 ENSG000002520872 ENSG000002523122 ENSG000002019012 ENSG000002025122 ENSG000002220682 ENSG000002225942 ENSG000002221742
- ENSG000002024152 ENSG000002018962 ENSG000002005432 ENSG000002529782 ENSG000002228892 ENSG000002232552 ENSG000002530202 ENSG000002002432
- RN7SKP72 ENSG000002230262 ENSG000002527942 ENSG000002225142 ENSG000002009662 ENSG000002016002 ENSG000002221122 ENSG000002226642
- ENSG000002225242 ENSG000001994202 ENSG000002222402 ENSG000002230562 ENSG000002001512 ENSG000002526332 RN7SKP22 ENSG000002227132
- ENSG000002010662 ENSG000002231182 ENSG000002222812 ENSG000002225892 ENSG000002006732 ENSG000002231422 ENSG000002229822 ENSG000002229982
- ENSG000002530102 ENSG000002004722 ENSG000002226362 ENSG000002230402 ENSG000002527162 ENSG000002530732 ENSG000002228982 ENSG000002224452
- ENSG000002525952 ENSG000002012892 ENSG000002007832 ENSG000002232992 ENSG000002001982 ENSG000002231202 ENSG000002023602 ENSG000002221542
- ENSG000002233082 ENSG000002516972 ENSG000002524642 ENSG000002013952 ENSG000002518402 ENSG000002221622 RN7SKP102 ENSG000002517762
- ENSG000002229742 ENSG000002521632 ENSG000002520842 ENSG000002527042 ENSG000002530012 ENSG000002224362 ENSG000002022602 ENSG000002224042
- ENSG000002523212 ENSG000002227062 ENSG000002518882 ENSG000002221072 ENSG000002008952 ENSG000002223862 ENSG000002020582 ENSG000002225742
- ENSG000002232602 ENSG000002017152 ENSG000002518102 ENSG000002383242 ENSG000002011402 ENSG000002220692 ENSG000002518252 ENSG000002015332
- ENSG000002227622 ENSG000002528382 ENSG000002220992 ENSG000002013152 RN7SKP82 ENSG000002004882 ENSG000002233212 ENSG000002233052
- ENSG000002013642 ENSG000002231172 ENSG000002007942 ENSG000002231262 ENSG000002221112 ENSG000001996222 ENSG000002526342 ENSG000002225152
- ENSG000002000472 ENSG000002221022 ENSG000001999402 ENSG000002015832 ENSG000002223432 ENSG000002528272 ENSG000002230392 ENSG000002023922
- ENSG000002402942 ENSG000002228262 ENSG000002222572 ENSG000002232692 ENSG000002522922 ENSG000002019672 ENSG000002024062 ENSG000002226932
- RN7SKP92 ENSG000002518092 ENSG000002022172 ENSG000002018752 ENSG000002023512 ENSG000002223372 ENSG000002001612 ENSG000002213992
- ENSG000002524902 ENSG000002014232 ENSG000002530152 ENSG000001998782 ENSG000002230422 ENSG000002022412 ENSG000002522332 ENSG000002223712
- ENSG000002223852 ENSG000002523222 ENSG000002523552 ENSG000001998832 ENSG000002007612 ENSG000002223132 ENSG000002072692 ENSG000002520282
- ENSG000002227052 ENSG000002016842 ENSG000002528792 ENSG000001997302 ENSG000002221792 ENSG000001991972 ENSG000002224522 ENSG000002223762
- ENSG000002530752 ENSG000002517142 ENSG000002232822 ENSG000002228592 ENSG000002230122 ENSG000002004752 ENSG000002226302 ENSG000001997192
- ENSG000002230752 ENSG000002232292 ENSG000002231362 ENSG000002519512 ENSG000002519822 ENSG000002003792 ENSG000002517422 ENSG000002530532
- ENSG000002228452 ENSG000002013582 ENSG000002233152 ENSG000002229762 ENSG000002007082 ENSG000002526632 ENSG000002010782 ENSG000002232232
- ENSG000002221642 ENSG000002228422
RN7SK for paralogs About GeneDecksing
|
Genomic Variants
for RN7SK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for RN7SK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RN7SK for disorders About GeneDecksing
OMIM gene information: 606515
OMIM disorders: --
1  disease for RN7SK: About MalaCardsimmunodeficiency
1 Novoseek disease relationship for RN7SK gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| immunodeficiency |
18.1 |
1 |
15169877 (1) |
Export disorders for RN7SK gene to outside databases
|
Publications
for RN7SK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RN7SK gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with RN7SK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The conserved 7SK snRNA gene localizes to human chromosome 6 by homolog exclusion probing of somatic cell hybrid RNA. (PubMed id 8139910)1, 3 Driscoll C.T....Maraia R.J. (1994)
- Structural analyses of the 7SK ribonucleoprotein (RNP ), the most abundant human small RNP of unknown function. (PubMed id 1646389)1, 3 Wassarman D.A. and Steitz J.A. (1991)
- Regulation of two key nuclear enzymatic activities by the 7SK small nuclear RNA. (PubMed id 17381310)1, 9 He W.J....Zhou Q. (2006)
- Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA. (PubMed id 14627702)1, 9 Chen R....Zhou Q. (2004)
- Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. (PubMed id 14580347)1, 9 Yik J.H.N.... Zhou Q. (2003)
- 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. (PubMed id 11713533)1, 9 Nguyen V.T....Bensaude O. (2001)
- Implication of the SMN complex in the biogenesis and s teady state level of the signal recognition particle. (PubMed id 23221635)1 Piazzon N....Massenet S. (2013)
- Bromodomain and extra-terminal (BET) bromodomain inhib ition activate transcription via transient release of positive transcription elo ngation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. (PubMed id 22952229)1 Bartholomeeusen K....Peterlin B.M. (2012)
- New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC). (PubMed id 21360054)1 He N. and Zhou Q. (2011)
- 7SK small nuclear RNA directly affects HMGA1 function in transcription regulation. (PubMed id 21087998)1 Eilebrecht S....Benecke A. (2011)
|
External Searches for RN7SK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RN7SK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RN7SK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RN7SK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RN7SK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RN7SK gene:
Search GeneIP for patents involving RN7SK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RN7SK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RN7SK | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RN7SK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RN7SK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RN7SK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RN7SK | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RN7SK |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RN7SK |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for RN7SK |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat RN7SK |
|
|
|
|
GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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