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Aliases for RMND5B Gene

Aliases for RMND5B Gene

  • Required For Meiotic Nuclear Division 5 Homolog B 2 3 5
  • GID Complex Subunit 2 Homolog B 2 3
  • Required For Meiotic Nuclear Division 5 Homolog B (S. Cerevisiae) 2
  • Protein RMD5 Homolog B 3
  • GID2B 3
  • GID2 3

External Ids for RMND5B Gene

Previous GeneCards Identifiers for RMND5B Gene

  • GC05P177492
  • GC05P177557
  • GC05P172284

Summaries for RMND5B Gene

GeneCards Summary for RMND5B Gene

RMND5B (Required For Meiotic Nuclear Division 5 Homolog B) is a Protein Coding gene. An important paralog of this gene is RMND5A.

Gene Wiki entry for RMND5B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMND5B Gene

Genomics for RMND5B Gene

Regulatory Elements for RMND5B Gene

Enhancers for RMND5B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F178077 0.8 Ensembl ENCODE 12.6 -52.1 -52126 1.2 HDGF PKNOX1 SIN3A ELK1 RCOR1 FOS HCFC1 ZHX2 GATAD2B ZNF592 CLK4 RMND5B N4BP3 FAM153C RPL19P9 LOC105377754 PIR41367
GH05F178075 0.7 Ensembl ENCODE 12.6 -54.3 -54323 0.7 HDAC1 ATF1 CREB3L1 KLF17 ARID4B SIN3A ZNF2 RAD21 ELK1 ZNF143 RMND5B CLK4 RPL19P9 LOC105377754 PIR41367
GH05F178104 0.2 Ensembl 12.5 -25.7 -25732 1.2 KLF1 ESRRA ZNF687 GATA3 GLIS1 KLF9 FOS EGR2 RMND5B GC05M178097 N4BP3
GH05F178086 0.8 Ensembl ENCODE 12.5 -44.0 -44019 0.7 HDGF GTF2F1 PKNOX1 JUN SIN3A E2F1 ZNF316 GATA3 CTBP1 ELK1 N4BP3 RMND5B FAM153C RPL19P9 LOC105377754 PIR41367
GH05F178079 0.6 ENCODE 12.5 -49.5 -49531 2.9 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF121 FOS NCOA1 REST ZNF592 RMND5B N4BP3 CLK4 RPL19P9 LOC105377754 PIR41367
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RMND5B on UCSC Golden Path with GeneCards custom track

Promoters for RMND5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001298029 568 2201 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 ZNF766 ZNF207 SP3

Genomic Location for RMND5B Gene

Chromosome:
5
Start:
178,130,532 bp from pter
End:
178,150,565 bp from pter
Size:
20,034 bases
Orientation:
Plus strand

Genomic View for RMND5B Gene

Genes around RMND5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMND5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMND5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMND5B Gene

Proteins for RMND5B Gene

  • Protein details for RMND5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G75-RMD5B_HUMAN
    Recommended name:
    Protein RMD5 homolog B
    Protein Accession:
    Q96G75
    Secondary Accessions:
    • Q1HE27
    • Q6UVY7
    • Q9H6F6

    Protein attributes for RMND5B Gene

    Size:
    393 amino acids
    Molecular mass:
    44414 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RMND5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RMND5B Gene

Post-translational modifications for RMND5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMND5B Gene

Domains & Families for RMND5B Gene

Suggested Antigen Peptide Sequences for RMND5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G75

UniProtKB/Swiss-Prot:

RMD5B_HUMAN :
  • Contains 1 CTLH domain.
Domain:
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with RMND5B: view

No data available for Gene Families for RMND5B Gene

Function for RMND5B Gene

Gene Ontology (GO) - Molecular Function for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with RMND5B: view
genes like me logo Genes that share phenotypes with RMND5B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RMND5B

miRNA for RMND5B Gene

miRTarBase miRNAs that target RMND5B

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMND5B Gene

Localization for RMND5B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RMND5B Gene COMPARTMENTS Subcellular localization image for RMND5B gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0034657 GID complex IBA --
genes like me logo Genes that share ontologies with RMND5B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RMND5B Gene

Pathways & Interactions for RMND5B Gene

SuperPathways for RMND5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RMND5B: view

No data available for Pathways by source and SIGNOR curated interactions for RMND5B Gene

Transcripts for RMND5B Gene

Unigene Clusters for RMND5B Gene

Required for meiotic nuclear division 5 homolog B (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMND5B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - -
SP10: -
SP11:
SP12: -

ExUns: 14d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RMND5B Gene

GeneLoc Exon Structure for
RMND5B
ECgene alternative splicing isoforms for
RMND5B

Expression for RMND5B Gene

mRNA expression in normal human tissues for RMND5B Gene

Protein differential expression in normal tissues from HIPED for RMND5B Gene

This gene is overexpressed in Testis (37.9) and Uterus (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RMND5B Gene



Protein tissue co-expression partners for RMND5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RMND5B Gene:

RMND5B

SOURCE GeneReport for Unigene cluster for RMND5B Gene:

Hs.27222
genes like me logo Genes that share expression patterns with RMND5B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RMND5B Gene

Orthologs for RMND5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RMND5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RMND5B 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia RMND5B 34 35
  • 92.45 (n)
cow
(Bos Taurus)
Mammalia RMND5B 34 35
  • 91.77 (n)
mouse
(Mus musculus)
Mammalia Rmnd5b 34 16 35
  • 89.06 (n)
rat
(Rattus norvegicus)
Mammalia Rmnd5b 34
  • 88.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RMND5B 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RMND5B 35
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rmnd5b 34 35
  • 69.48 (n)
zgc73277 34
fruit fly
(Drosophila melanogaster)
Insecta CG3295 35
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07D1.2 34 35
  • 40.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RMD5 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7116 35
  • 48 (a)
OneToMany
Species where no ortholog for RMND5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RMND5B Gene

ENSEMBL:
Gene Tree for RMND5B (if available)
TreeFam:
Gene Tree for RMND5B (if available)

Paralogs for RMND5B Gene

Paralogs for RMND5B Gene

(2) SIMAP similar genes for RMND5B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RMND5B: view

Variants for RMND5B Gene

Sequence variations from dbSNP and Humsavar for RMND5B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036388 -- 178,131,928(+) aatgt(G/T)gagtt intron-variant
rs10040895 -- 178,134,859(+) GTAAT(A/C)CCAGC intron-variant
rs10042021 -- 178,134,905(+) CCGGG(A/G)GGTGG intron-variant
rs10058984 -- 178,130,632(+) CTGTA(A/G)GCGTA upstream-variant-2KB, utr-variant-5-prime
rs10060446 -- 178,135,250(+) AAGCA(A/G)TCCTC intron-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RMND5B Gene

Variant ID Type Subtype PubMed ID
dgv5844n100 CNV gain 25217958
esv3352132 CNV duplication 20981092
esv3607706 CNV loss 21293372
nsv1019404 CNV gain 25217958
nsv1120062 OTHER inversion 24896259
nsv462567 CNV loss 19166990
nsv471058 CNV loss 18288195
nsv600392 CNV loss 21841781
nsv600394 CNV loss 21841781

Variation tolerance for RMND5B Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RMND5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RMND5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMND5B Gene

Disorders for RMND5B Gene

Relevant External Links for RMND5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RMND5B

No disorders were found for RMND5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMND5B Gene

Publications for RMND5B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3 64

Products for RMND5B Gene

Sources for RMND5B Gene

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