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RMND5B Gene

protein-coding   GIFtS: 50
GCID: GC05P177557

Required For Meiotic Nuclear Division 5 Homolog B (S. Cerevisiae)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Required For Meiotic Nuclear Division 5 Homolog B (S. Cerevisiae)1 2
GID Complex Subunit 2 Homolog B1 2
GID22
GID2B2
Protein RMD5 Homolog B2

External Ids:    HGNC: 261811   Entrez Gene: 647772   Ensembl: ENSG000001459167   UniProtKB: Q96G753   

Export aliases for RMND5B gene to outside databases

Previous GC identifers: GC05P177492 GC05P172284


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RMND5B Gene:
RMND5B (required for meiotic nuclear division 5 homolog B (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is RMND5A.

Gene Wiki entry for RMND5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_023133.14  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RMND5B gene promoter:
         Max1   Elk-1   SREBP-1c   COUP   SREBP-1b   HEN1   FAC1   IRF-2   SREBP-1a   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRMND5B promoter sequence
   Search Chromatin IP Primers for RMND5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RMND5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RMND5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RMND5B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P177557:  view genomic region     (about GC identifiers)

Start:
177,557,997 bp from pter      End:
177,577,566 bp from pter
Size:
19,570 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RMD5B_HUMAN, Q96G75 (See protein sequence)
Recommended Name: Protein RMD5 homolog B  
Size: 393 amino acids; 44414 Da
Sequence caution: Sequence=BAB15303.1; Type=Erroneous initiation;
Secondary accessions: Q1HE27 Q6UVY7 Q9H6F6
Alternative splicing: 2 isoforms:  Q96G75-1   Q96G75-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RMND5B: NX_Q96G75

Explore proteomics data for RMND5B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RMND5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001275723.1  NP_001275724.1  NP_073599.2  

    ENSEMBL proteins: 
     ENSP00000320623   ENSP00000420875   ENSP00000424928   ENSP00000421553   ENSP00000425920  
     ENSP00000426588   ENSP00000423251   ENSP00000437630  

    RMND5B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR027370 Znf-RING_LisH
     IPR013083 Znf_RING/FYVE/PHD
     IPR006594 LisH_dimerisation
     IPR013144 CRA_dom
     IPR024964 CTLH/CRA

    Graphical View of Domain Structure for InterPro Entry Q96G75

    ProtoNet protein and cluster: Q96G75

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB006595 CTLH


    UniProtKB/Swiss-Prot: RMD5B_HUMAN, Q96G75
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain


    Find genes that share domains with RMND5B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RMND5B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RMND5B:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RMND5B
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RMND5B

    miRNA
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    miRTarBase miRNAs that target RMND5B:
    hsa-mir-93-5p (MIRT048892)

    Block miRNA regulation of human, mouse, rat RMND5B using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate RMND5B:
    hsa-miR-485-5p hsa-miR-3157-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidRMND5B 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RMND5B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RMND5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RMND5B
    Interactions:

        Search GeneGlobe Interaction Network for RMND5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RMND5B (Q96G752, 3 ENSP000003206234) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134852, 3MINT-61979 I2D: score=3 
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RMND5B (RMD5B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RMND5B gene (3 alternative transcripts): 
    NM_001288794.1  NM_001288795.1  NM_022762.4  

    Unigene Cluster for RMND5B:

    Required for meiotic nuclear division 5 homolog B (S. cerevisiae)
    Hs.27222  [show with all ESTs]
    Unigene Representative Sequence: AK122692
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313386(uc003mim.3) ENST00000515098(uc003min.3) ENST00000507575(uc011dgf.2)
    ENST00000502814 ENST00000512663 ENST00000507457 ENST00000508647 ENST00000512811
    ENST00000515360(uc003miq.3) ENST00000513162 ENST00000507937 ENST00000542098(uc003mio.3)

    miRNA
    Products:
         
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    3 qRT-PCR Assays for microRNAs that regulate RMND5B:
    hsa-miR-485-5p hsa-miR-3157-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidRMND5B 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat RMND5B
    Clone
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    OriGene ORF clones in mouse, rat for RMND5B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RMND5B (NM_022762)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RMND5B
      QuantiTect SYBR Green Assays in human, mouse, rat RMND5B
      QuantiFast Probe-based Assays in human, mouse, rat RMND5B

    Additional mRNA sequence: 

    AK025971.1 AK093481.1 AK093622.1 AK094065.1 AK122692.1 AK125337.1 AL137381.1 AL713670.1 
    AY359092.1 BC009911.2 DQ494789.1 

    Selected DOTS entries (see all 40):

    DT.85105614  DT.100773957  DT.448702  DT.91847179  DT.120854792  DT.87016231  DT.100032079  DT.100738227 
    DT.100792177  DT.100792178  DT.120854763  DT.100027886  DT.120854788  DT.95349614  DT.120854707  DT.100792182 
    DT.100640354  DT.120854744  DT.120854737  DT.92435912  DT.100700073  DT.100657174  DT.120854770  DT.120854776 

    Selected AceView cDNA sequences (see all 235):

    BM919814 AK025971 BU535669 AI929308 BQ058981 BI836485 BQ690204 CR598018 
    AX748436 AI278358 AA149481 BI829086 BI830114 BI089705 AL137381 CR616716 
    BU618684 AK094065 AK122692 BM702035 AA847459 BM925811 W00526 NM_022762 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RMND5B (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ·
    SP1:                          -     -     -     -     -                       -                                         -                                       
    SP2:              -     -     -                 -     -                       -                                         -                                       
    SP3:                                                                          -                                         -                                       
    SP4:        -     -     -     -                 -     -                                                                 -                                       
    SP5:                                            -     -                                                                                                         

    ExUns: 14d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RMND5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RMND5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATGCTAT
    RMND5B Expression
    About this image

    RMND5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RMND5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.27222
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RMND5B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rmnd5b1 , 5 required for meiotic nuclear division 5 homolog B (S. more1, 5 89.06(n)1
    97.71(a)1
      11 (31.15 cM)5
    660891  NM_025346.11  NP_079622.11 
     516236715 
    lizard
    (Anolis carolinensis)
    Reptilia RMND5B6
    required for meiotic nuclear division 5 homolog B ...
    85(a)
    1 ↔ 1
    2(146207326-146216830)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732772 hypothetical protein MGC73277 75.41(n)   393747  BC059606.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32956
    --
    39(a)
    1 → many
    2R(16903099-16904951)
    worm
    (Caenorhabditis elegans)
    Secernentea T07D1.21 T07D1.2 40.81(n)
    28.97(a)
      180548  NM_076043.3  NP_508444.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RMD56
    Conserved protein that has an E3-like ubiquitin li...
    22(a)
    1 → many
    IV(966557-967822) YDR255C


    ENSEMBL Gene Tree for RMND5B (if available)
    TreeFam Gene Tree for RMND5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RMND5B gene
    RMND5A2  
    2 SIMAP similar genes for RMND5B using alignment to 7 protein entries:     RMD5B_HUMAN (see all proteins):
    DKFZp434K0926    RMND5A

    Find genes that share paralogs with RMND5B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RMND5B (see all 497)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132045971,2
    C,F--177556134(+) GTTCAC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1490873501,2
    --177556211(+) GGCCAA/GCATGG 1 -- us2k10--------
    rs1432834161,2
    C--177556391(+) CTTCAC/TCTCAA 1 -- us2k10--------
    rs134368761,2
    C,F,H--177556429(+) CCTGGG/ATTTGG 1 -- us2k122Minor allele frequency- A:0.28NS EA NA WA 2350
    rs1146337591,2
    F--177556525(+) CGTTCC/TCCAGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs733498061,2
    C,F--177556615(+) CAGATT/GAAGTT 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1924153011,2
    --177556635(+) GGGACC/GAGAAA 1 -- us2k10--------
    rs1141899051,2
    F--177556649(+) TGGGAC/TAGGAA 1 -- us2k12Minor allele frequency- T:0.05NA EA 240
    rs2004922671,2
    --177556660(+) AGGAG-/TTTTC 
            
    TTTTC
    1 -- us2k10--------
    rs2020286431,2
    C--177556669(+) CTTTTC/TTTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RMND5B (177557997 - 177577566 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RMND5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883192CNV Loss21882294
    nsv462567CNV Loss19166990
    nsv471058CNV Loss18288195
    nsv883190CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RMND5B gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with RMND5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64777 HGNC: 26181 AceView: FLJ22318 Ensembl:ENSG00000145916 euGenes: HUgn64777
    ECgene: RMND5B H-InvDB: RMND5B

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RMND5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RMND5B gene:
    Search GeneIP for patents involving RMND5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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