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Aliases for RMND5B Gene

Aliases for RMND5B Gene

  • Required For Meiotic Nuclear Division 5 Homolog B 2 3 5
  • GID Complex Subunit 2 Homolog B 2 3
  • Required For Meiotic Nuclear Division 5 Homolog B (S. Cerevisiae) 2
  • Protein RMD5 Homolog B 3
  • GID2B 3
  • GID2 3

External Ids for RMND5B Gene

Previous GeneCards Identifiers for RMND5B Gene

  • GC05P177492
  • GC05P177557
  • GC05P172284

Summaries for RMND5B Gene

GeneCards Summary for RMND5B Gene

RMND5B (Required For Meiotic Nuclear Division 5 Homolog B) is a Protein Coding gene. An important paralog of this gene is RMND5A.

Gene Wiki entry for RMND5B Gene

Additional gene information for RMND5B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMND5B Gene

Genomics for RMND5B Gene

Regulatory Elements for RMND5B Gene

Enhancers for RMND5B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H178203 1.4 ENCODE dbSUPER 21.3 +79.3 79297 12.1 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000247679 LOC202181 ZNF354C FAM193B ZNF879 CLK4 RPL21P60 RMND5B ENSG00000254035 ZFP2
GH05H178075 1.2 Ensembl ENCODE 23.1 -54.4 -54368 0.6 HDAC1 ATF1 NFIB RB1 ARNT ARID4B SIN3A KLF17 ZNF2 RAD21 RMND5B NSD1 ENSG00000247679 CLK4 RPL19P9 LOC105377754 PIR41367
GH05H178111 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -10.4 -10415 16.8 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF143 ZNF207 NSD1 ENSG00000247679 ZNF879 ZNF354B LOC202181 CLK4 ZNF354C N4BP3 FAM193B RMND5B
GH05H177425 1.8 FANTOM5 ENCODE dbSUPER 10.6 -701.2 -701161 8.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 CBX5 NSD1 GRK6 FAF2 UIMC1 DOK3 ENSG00000247679 LOC202181 ZNF346-IT1 PFN3 FAM193B
GH05H177453 1.7 Ensembl ENCODE dbSUPER 10.6 -673.7 -673668 6.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF346 NSD1 ZNF346-IT1 LOC202181 UIMC1 ENSG00000247679 SLC34A1 F12 GRK6 PFN3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RMND5B on UCSC Golden Path with GeneCards custom track

Promoters for RMND5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191404 468 1601 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF207 SP3 REST ZNF592

Genomic Locations for RMND5B Gene

Genomic Locations for RMND5B Gene
20,034 bases
Plus strand

Genomic View for RMND5B Gene

Genes around RMND5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMND5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMND5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMND5B Gene

Proteins for RMND5B Gene

  • Protein details for RMND5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RMD5 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q1HE27
    • Q6UVY7
    • Q9H6F6

    Protein attributes for RMND5B Gene

    393 amino acids
    Molecular mass:
    44414 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RMND5B Gene


neXtProt entry for RMND5B Gene

Post-translational modifications for RMND5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMND5B Gene

Domains & Families for RMND5B Gene

Gene Families for RMND5B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RMND5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RMND5B: view

No data available for UniProtKB/Swiss-Prot for RMND5B Gene

Function for RMND5B Gene

Gene Ontology (GO) - Molecular Function for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IPI 27173435
genes like me logo Genes that share ontologies with RMND5B: view
genes like me logo Genes that share phenotypes with RMND5B: view

Animal Model Products

miRNA for RMND5B Gene

miRTarBase miRNAs that target RMND5B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMND5B Gene

Localization for RMND5B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMND5B gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0034657 GID complex IBA --
genes like me logo Genes that share ontologies with RMND5B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RMND5B Gene

Pathways & Interactions for RMND5B Gene

SuperPathways for RMND5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RMND5B: view

No data available for Pathways by source and SIGNOR curated interactions for RMND5B Gene

Drugs & Compounds for RMND5B Gene

No Compound Related Data Available

Transcripts for RMND5B Gene

Unigene Clusters for RMND5B Gene

Required for meiotic nuclear division 5 homolog B (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMND5B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - -
SP10: -
SP12: -

ExUns: 14d

Relevant External Links for RMND5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMND5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RMND5B Gene

Protein differential expression in normal tissues from HIPED for RMND5B Gene

This gene is overexpressed in Testis (37.9) and Uterus (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RMND5B Gene

Protein tissue co-expression partners for RMND5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RMND5B Gene:


SOURCE GeneReport for Unigene cluster for RMND5B Gene:


Evidence on tissue expression from TISSUES for RMND5B Gene

  • Lung(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RMND5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMND5B Gene

Orthologs for RMND5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RMND5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RMND5B 33 34
  • 99.32 (n)
(Canis familiaris)
Mammalia RMND5B 33 34
  • 92.45 (n)
(Bos Taurus)
Mammalia RMND5B 33 34
  • 91.77 (n)
(Mus musculus)
Mammalia Rmnd5b 33 16 34
  • 89.06 (n)
(Rattus norvegicus)
Mammalia LOC361780 33
  • 88.89 (n)
(Ornithorhynchus anatinus)
Mammalia RMND5B 34
  • 82 (a)
(Anolis carolinensis)
Reptilia RMND5B 34
  • 85 (a)
(Danio rerio)
Actinopterygii rmnd5b 33 34
  • 69.48 (n)
zgc73277 33
fruit fly
(Drosophila melanogaster)
Insecta CG3295 34
  • 39 (a)
(Caenorhabditis elegans)
Secernentea T07D1.2 33 34
  • 40.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RMD5 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7116 34
  • 48 (a)
Species where no ortholog for RMND5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RMND5B Gene

Gene Tree for RMND5B (if available)
Gene Tree for RMND5B (if available)

Paralogs for RMND5B Gene

Paralogs for RMND5B Gene

(2) SIMAP similar genes for RMND5B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RMND5B: view

Variants for RMND5B Gene

Sequence variations from dbSNP and Humsavar for RMND5B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000026529 -- 178,138,604(+) AGTGA(C/T)CCTCC intron-variant
rs1000054862 -- 178,137,509(+) ACAGA(C/G)AGACC intron-variant
rs1000097282 -- 178,144,980(+) TGTTT(G/T)TTTAG intron-variant
rs1000122032 -- 178,131,046(+) GGCTG(C/T)GGGGC utr-variant-5-prime
rs1000179599 -- 178,132,041(+) GGCAC(A/G)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RMND5B Gene

Variant ID Type Subtype PubMed ID
nsv600394 CNV loss 21841781
nsv600392 CNV loss 21841781
nsv471058 CNV loss 18288195
nsv462567 CNV loss 19166990
nsv1120062 OTHER inversion 24896259
nsv1019404 CNV gain 25217958
esv3607706 CNV loss 21293372
esv3352132 CNV duplication 20981092
dgv5844n100 CNV gain 25217958

Variation tolerance for RMND5B Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RMND5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMND5B Gene

Disorders for RMND5B Gene

Relevant External Links for RMND5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RMND5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMND5B Gene

Publications for RMND5B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for RMND5B Gene

Sources for RMND5B Gene

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