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Aliases for RMND5B Gene

Aliases for RMND5B Gene

  • Required For Meiotic Nuclear Division 5 Homolog B 2 3 5
  • GID Complex Subunit 2 Homolog B 2 3
  • Required For Meiotic Nuclear Division 5 Homolog B (S. Cerevisiae) 2
  • GID2B 3
  • GID2 3

External Ids for RMND5B Gene

Previous GeneCards Identifiers for RMND5B Gene

  • GC05P177492
  • GC05P177557
  • GC05P172284

Summaries for RMND5B Gene

GeneCards Summary for RMND5B Gene

RMND5B (Required For Meiotic Nuclear Division 5 Homolog B) is a Protein Coding gene. An important paralog of this gene is RMND5A.

Gene Wiki entry for RMND5B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMND5B Gene

Genomics for RMND5B Gene

Regulatory Elements for RMND5B Gene

Promoters for RMND5B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RMND5B on UCSC Golden Path with GeneCards custom track

Genomic Location for RMND5B Gene

Chromosome:
5
Start:
178,130,532 bp from pter
End:
178,150,565 bp from pter
Size:
20,034 bases
Orientation:
Plus strand

Genomic View for RMND5B Gene

Genes around RMND5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMND5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMND5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMND5B Gene

Proteins for RMND5B Gene

  • Protein details for RMND5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G75-RMD5B_HUMAN
    Recommended name:
    Protein RMD5 homolog B
    Protein Accession:
    Q96G75
    Secondary Accessions:
    • Q1HE27
    • Q6UVY7
    • Q9H6F6

    Protein attributes for RMND5B Gene

    Size:
    393 amino acids
    Molecular mass:
    44414 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RMND5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RMND5B Gene

Proteomics data for RMND5B Gene at MOPED

Post-translational modifications for RMND5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RMND5B

No data available for DME Specific Peptides for RMND5B Gene

Domains & Families for RMND5B Gene

Suggested Antigen Peptide Sequences for RMND5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G75

UniProtKB/Swiss-Prot:

RMD5B_HUMAN :
  • Contains 1 CTLH domain.
Domain:
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with RMND5B: view

No data available for Gene Families for RMND5B Gene

Function for RMND5B Gene

genes like me logo Genes that share phenotypes with RMND5B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RMND5B

miRNA for RMND5B Gene

miRTarBase miRNAs that target RMND5B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMND5B Gene

Localization for RMND5B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RMND5B Gene COMPARTMENTS Subcellular localization image for RMND5B gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RMND5B Gene

Pathways & Interactions for RMND5B Gene

SuperPathways for RMND5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMND5B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RMND5B Gene

Drugs & Compounds for RMND5B Gene

No Compound Related Data Available

Transcripts for RMND5B Gene

Unigene Clusters for RMND5B Gene

Required for meiotic nuclear division 5 homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RMND5B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - -
SP10: -
SP11:
SP12: -

ExUns: 14d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RMND5B Gene

GeneLoc Exon Structure for
RMND5B
ECgene alternative splicing isoforms for
RMND5B

Expression for RMND5B Gene

mRNA expression in normal human tissues for RMND5B Gene

Protein differential expression in normal tissues from HIPED for RMND5B Gene

This gene is overexpressed in Testis (37.9) and Uterus (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMND5B Gene



SOURCE GeneReport for Unigene cluster for RMND5B Gene Hs.27222

genes like me logo Genes that share expression patterns with RMND5B: view

Protein tissue co-expression partners for RMND5B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RMND5B Gene

Orthologs for RMND5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RMND5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RMND5B 36
  • 100 (a)
OneToOne
RMND5B 35
  • 99.32 (n)
  • 99.75 (a)
cow
(Bos Taurus)
Mammalia RMND5B 36
  • 95 (a)
OneToOne
RMND5B 35
  • 91.77 (n)
  • 95.42 (a)
dog
(Canis familiaris)
Mammalia RMND5B 35
  • 92.45 (n)
  • 97.2 (a)
RMND5B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rmnd5b 16
Rmnd5b 35
  • 89.06 (n)
  • 97.71 (a)
Rmnd5b 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RMND5B 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rmnd5b 35
  • 88.89 (n)
  • 98.22 (a)
lizard
(Anolis carolinensis)
Reptilia RMND5B 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rmnd5b 35
  • 69.48 (n)
  • 73.15 (a)
zgc73277 35
rmnd5b 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3295 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07D1.2 36
  • 22 (a)
OneToMany
T07D1.2 35
  • 40.81 (n)
  • 28.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RMD5 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7116 36
  • 48 (a)
OneToMany
Species with no ortholog for RMND5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RMND5B Gene

ENSEMBL:
Gene Tree for RMND5B (if available)
TreeFam:
Gene Tree for RMND5B (if available)

Paralogs for RMND5B Gene

Paralogs for RMND5B Gene

(2) SIMAP similar genes for RMND5B Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RMND5B: view

Variants for RMND5B Gene

Sequence variations from dbSNP and Humsavar for RMND5B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3812071 -- 178,148,265(-) GGAGC(A/G)CAGAG utr-variant-3-prime
rs4590193 -- 178,137,345(+) AGTAC(A/G)TAGAA intron-variant
rs6893500 -- 178,138,361(+) AGGAT(A/G)TTGGT intron-variant, utr-variant-5-prime
rs6893797 -- 178,141,144(+) gaggg(A/T)gtccc intron-variant
rs6878658 -- 178,132,744(+) TTTTT(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RMND5B Gene

Variant ID Type Subtype PubMed ID
nsv462567 CNV Loss 19166990
nsv471058 CNV Loss 18288195
nsv883190 CNV Loss 21882294
nsv883192 CNV Loss 21882294

Variation tolerance for RMND5B Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RMND5B Gene

HapMap Linkage Disequilibrium report
RMND5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMND5B Gene

Disorders for RMND5B Gene

Relevant External Links for RMND5B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RMND5B

No disorders were found for RMND5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMND5B Gene

Publications for RMND5B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3

Products for RMND5B Gene

Sources for RMND5B Gene

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