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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RMND5B Gene

protein-coding   GIFtS: 49
GCID: GC05P177557

Required For Meiotic Nuclear Division 5 Homolog B (S. Cerevisiae)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Required For Meiotic Nuclear Division 5 Homolog B (S. Cerevisiae)1 2
GID Complex Subunit 2 Homolog B1 2
GID22
GID2B2
Protein RMD5 Homolog B2

External Ids:    HGNC: 261811   Entrez Gene: 647772   Ensembl: ENSG000001459167   UniProtKB: Q96G753   

Export aliases for RMND5B gene to outside databases

Previous GC identifers: GC05P177492 GC05P172284


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RMND5B Gene: 
RMND5B (required for meiotic nuclear division 5 homolog B (S. cerevisiae)) is a protein-coding gene. Diseases associated with RMND5B include lissencephaly. An important paralog of this gene is RMND5A.

Gene Wiki entry for RMND5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RMND5B gene promoter:
         Max1   Elk-1   SREBP-1c   COUP   SREBP-1b   HEN1   FAC1   IRF-2   SREBP-1a   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRMND5B promoter sequence
   Search SABiosciences Chromatin IP Primers for RMND5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RMND5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

RMND5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RMND5B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P177557:  view genomic region     (about GC identifiers)

Start:
177,557,997 bp from pter      End:
177,577,566 bp from pter
Size:
19,570 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RMD5B_HUMAN, Q96G75 (See protein sequence)
Recommended Name: Protein RMD5 homolog B  
Size: 393 amino acids; 44414 Da
Sequence caution: Sequence=BAB15303.1; Type=Erroneous initiation;
Secondary accessions: Q1HE27 Q6UVY7 Q9H6F6
Alternative splicing: 2 isoforms:  Q96G75-1   Q96G75-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RMND5B: NX_Q96G75

Explore proteomics data for RMND5B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96G75

  • RMND5B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RMND5B Protein Expression
    REFSEQ proteins: NP_073599.2  
    ENSEMBL proteins: 
     ENSP00000320623   ENSP00000420875   ENSP00000424928   ENSP00000421553   ENSP00000425920  
     ENSP00000426588   ENSP00000423251   ENSP00000437630  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR027370 zf-RING_LisH
     IPR013083 Znf_RING/FYVE/PHD
     IPR006594 LisH_dimerisation
     IPR013144 CRA_dom
     IPR024964 CTLH/CRA

    Graphical View of Domain Structure for InterPro Entry Q96G75

    ProtoNet protein and cluster: Q96G75

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB006595 CTLH


    UniProtKB/Swiss-Prot: RMD5B_HUMAN, Q96G75
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain


    RMND5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    RMND5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RMND5B:
     Increased G2M DNA content 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidRMND5B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RMND5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/16 Interacting proteins for RMND5B (Q96G752, 3 ENSP000003206234) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD4Q134852, 3MINT-61979 I2D: score=3 
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    SHBGP042783, ENSP000003698164I2D: score=3 STRING: ENSP00000369816
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RMND5B (RMD5B)

    Search CenterWatch for drugs/clinical trials and news about RMND5B / RMD5B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RMND5B gene: 
    NM_022762.3  

    Unigene Cluster for RMND5B:

    Required for meiotic nuclear division 5 homolog B (S. cerevisiae)
    Hs.27222  [show with all ESTs]
    Unigene Representative Sequence: AK122692
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313386(uc003mim.3) ENST00000515098(uc003min.3) ENST00000507575(uc011dgf.2)
    ENST00000502814 ENST00000512663 ENST00000507457 ENST00000508647 ENST00000512811
    ENST00000515360(uc003miq.3) ENST00000513162 ENST00000507937 ENST00000542098(uc003mio.3)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate RMND5B:
    hsa-miR-485-5p hsa-miR-3157-5p hsa-miR-3616-3p
    SwitchGear 3'UTR luciferase reporter plasmidRMND5B 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RMND5B

    Additional mRNA sequence: 

    AK025971.1 AK093481.1 AK093622.1 AK094065.1 AK122692.1 AK125337.1 AL137381.1 AL713670.1 
    AY359092.1 BC009911.2 DQ494789.1 

    24/40 DOTS entries (see all 40):

    DT.85105614  DT.100773957  DT.448702  DT.91847179  DT.120854792  DT.87016231  DT.100032079  DT.100738227 
    DT.100792177  DT.100792178  DT.120854763  DT.100027886  DT.120854788  DT.95349614  DT.120854707  DT.100792182 
    DT.100640354  DT.120854744  DT.120854737  DT.92435912  DT.100700073  DT.100657174  DT.120854770  DT.120854776 

    24/235 AceView cDNA sequences (see all 235):

    CR607362 BQ016127 Z38371 AA159060 AA847459 W00526 BU739754 CR616716 
    BM925811 BU618684 AX748436 BM702035 AA922883 AK094065 CD244156 AL713670 
    AW731874 CR609872 AW583420 BM919814 AI929308 BU535669 BQ067670 BI830114 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RMND5B (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ·
    SP1:                          -     -     -     -     -                       -                                         -                                       
    SP2:              -     -     -                 -     -                       -                                         -                                       
    SP3:                                                                          -                                         -                                       
    SP4:        -     -     -     -                 -     -                                                                 -                                       
    SP5:                                            -     -                                                                                                         

    ExUns: 14d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RMND5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RMND5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAATGCTAT
    RMND5B Expression
    About this image


    See RMND5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RMND5B

    SOURCE GeneReport for Unigene cluster: Hs.27222
        SABiosciences Custom PCR Arrays for RMND5B
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RMND5B gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rmnd5b1 , 5 required for meiotic nuclear division 5 homolog B (S. more1, 5 89.06(n)1
    97.71(a)1
      11 (31.15 cM)5
    660891  NM_025346.11  NP_079622.11 
     516236715 
    lizard
    (Anolis carolinensis)
    Reptilia RMND5B6
    Uncharacterized protein
    85(a)
    1 ↔ 1
    2(146207326-146216830)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732772 hypothetical protein MGC73277 75.41(n)   393747  BC059606.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG32956
    --
    39(a)
    1 → many
    2R(16903099-16904951)
    worm
    (Caenorhabditis elegans)
    Secernentea T07D1.26
    Protein T07D1.2
    21(a)
    1 → many
    X(2429859-2439160)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RMD56
    Conserved protein that has an E3-like ubiquitin li...
    21(a)
    1 → many
    IV(966557-967822)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G378801 LisH/CRA/RING-U-box domain-containing protein 46.2(n)
    37.13(a)
      829944  NM_119949.4  NP_195501.1 


    ENSEMBL Gene Tree for RMND5B (if available)
    TreeFam Gene Tree for RMND5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RMND5B gene
    RMND5A2  
    2 SIMAP similar genes for RMND5B using alignment to 7 protein entries:     RMD5B_HUMAN (see all proteins):
    DKFZp434K0926    RMND5A

    RMND5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/497 SNPs in RMND5B are shown (see all 497)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132045971,2
    C,F--177556134(+) GTTCAC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1490873501,2
    --177556211(+) GGCCAA/GCATGG 1 -- us2k10--------
    rs1432834161,2
    C--177556391(+) CTTCAC/TCTCAA 1 -- us2k10--------
    rs134368761,2
    C,F,H--177556429(+) CCTGGG/ATTTGG 1 -- us2k122Minor allele frequency- A:0.28NS EA NA WA 2350
    rs1146337591,2
    F--177556525(+) CGTTCC/TCCAGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs733498061,2
    C,F--177556615(+) CAGATT/GAAGTT 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1924153011,2
    --177556635(+) GGGACC/GAGAAA 1 -- us2k10--------
    rs1141899051,2
    F--177556649(+) TGGGAC/TAGGAA 1 -- us2k12Minor allele frequency- T:0.05NA EA 240
    rs2004922671,2
    --177556660(+) AGGAG-/TTTTC 
            
    TTTTC
    1 -- us2k10--------
    rs2020286431,2
    C--177556669(+) CTTTTC/TTTTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RMND5B (177557997 - 177577566 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RMND5B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883192CNV Loss21882294
    nsv462567CNV Loss19166990
    nsv471058CNV Loss18288195
    nsv883190CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for RMND5B:    About MalaCards
    lissencephaly    


    RMND5B for disorders           About GeneDecksing


    Export disorders for RMND5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RMND5B gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with RMND5B)
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    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    10. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PubMed id 15862967)1 Pope S.N. and Lee I.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64777 HGNC: 26181 AceView: FLJ22318 Ensembl:ENSG00000145916 euGenes: HUgn64777
    ECgene: RMND5B H-InvDB: RMND5B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RMND5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RMND5B gene:
    Search GeneIP for patents involving RMND5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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