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Aliases for RMND5A Gene

Aliases for RMND5A Gene

  • Required For Meiotic Nuclear Division 5 Homolog A 2 3 5
  • 44-KD Protein Coding For CTLH Motif 2 3
  • GID Complex Subunit 2 Homolog A 2 3
  • Required For Meiotic Nuclear Division 5 Homolog A (S. Cerevisiae) 2
  • C-Terminal To LisH Motif, 44 KDa 3
  • P44CTLH 3
  • GID2A 3
  • CTLH 3
  • GID2 3
  • RMD5 3

External Ids for RMND5A Gene

Previous GeneCards Identifiers for RMND5A Gene

  • GC02P086800
  • GC02P086947

Summaries for RMND5A Gene

GeneCards Summary for RMND5A Gene

RMND5A (Required For Meiotic Nuclear Division 5 Homolog A) is a Protein Coding gene. Diseases associated with RMND5A include Meningoencephalocele. An important paralog of this gene is RMND5B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMND5A Gene

Genomics for RMND5A Gene

Regulatory Elements for RMND5A Gene

Enhancers for RMND5A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RMND5A on UCSC Golden Path with GeneCards custom track

Promoters for RMND5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RMND5A on UCSC Golden Path with GeneCards custom track

Genomic Location for RMND5A Gene

Chromosome:
2
Start:
86,720,173 bp from pter
End:
86,778,041 bp from pter
Size:
57,869 bases
Orientation:
Plus strand

Genomic View for RMND5A Gene

Genes around RMND5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMND5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMND5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMND5A Gene

Proteins for RMND5A Gene

  • Protein details for RMND5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H871-RMD5A_HUMAN
    Recommended name:
    Protein RMD5 homolog A
    Protein Accession:
    Q9H871
    Secondary Accessions:
    • D6W5M6
    • Q6NTF0
    • Q9H6W5
    • Q9H9H2

    Protein attributes for RMND5A Gene

    Size:
    391 amino acids
    Molecular mass:
    43993 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RMND5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RMND5A Gene

Proteomics data for RMND5A Gene at MOPED

Post-translational modifications for RMND5A Gene

  • Ubiquitination at Lys 17, Lys 218, and Lys 365
  • Modification sites at PhosphoSitePlus

Other Protein References for RMND5A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RMND5A Gene

Domains & Families for RMND5A Gene

Suggested Antigen Peptide Sequences for RMND5A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H871

UniProtKB/Swiss-Prot:

RMD5A_HUMAN :
  • Contains 1 CTLH domain.
Domain:
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with RMND5A: view

No data available for Gene Families for RMND5A Gene

Function for RMND5A Gene

Phenotypes for RMND5A Gene

GenomeRNAi human phenotypes for RMND5A:
genes like me logo Genes that share phenotypes with RMND5A: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMND5A Gene

Localization for RMND5A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RMND5A Gene COMPARTMENTS Subcellular localization image for RMND5A gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RMND5A Gene

Pathways & Interactions for RMND5A Gene

SuperPathways for RMND5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMND5A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RMND5A Gene

Drugs & Compounds for RMND5A Gene

No Compound Related Data Available

Transcripts for RMND5A Gene

Unigene Clusters for RMND5A Gene

Required for meiotic nuclear division 5 homolog A (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RMND5A Gene

No ASD Table

Relevant External Links for RMND5A Gene

GeneLoc Exon Structure for
RMND5A
ECgene alternative splicing isoforms for
RMND5A

Expression for RMND5A Gene

mRNA expression in normal human tissues for RMND5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RMND5A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for RMND5A Gene

This gene is overexpressed in Liver (58.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMND5A Gene



SOURCE GeneReport for Unigene cluster for RMND5A Gene Hs.75277

genes like me logo Genes that share expression patterns with RMND5A: view

Protein tissue co-expression partners for RMND5A Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RMND5A Gene

Orthologs for RMND5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RMND5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RMND5A 35
  • 94.8 (n)
  • 100 (a)
RMND5A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RMND5A 35
  • 96.16 (n)
  • 100 (a)
RMND5A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rmnd5a 35
  • 95.06 (n)
  • 100 (a)
Rmnd5a 16
Rmnd5a 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RMND5A 35
  • 99.71 (n)
  • 99.71 (a)
RMND5A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rmnd5a 35
  • 94.03 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia RMND5A 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RMND5A 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751091 35
  • 84.62 (n)
  • 95.99 (a)
lizard
(Anolis carolinensis)
Reptilia RMND5A 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rmnd5a 35
  • 81.33 (n)
  • 93.86 (a)
Str.1465 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6044 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011892 35
  • 51.85 (n)
  • 49.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3295 35
  • 52.51 (n)
  • 48.31 (a)
CG3295 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07D1.2 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RMD5 36
  • 23 (a)
OneToMany
RMD5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G37880 35
  • 48.14 (n)
  • 38.66 (a)
rice
(Oryza sativa)
Liliopsida Os06g0588900 35
  • 48.36 (n)
  • 38.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.729 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00898 35
  • 45.3 (n)
  • 41.03 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC29A3.03c 35
  • 44.58 (n)
  • 32.82 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7116 36
  • 48 (a)
OneToMany
Species with no ortholog for RMND5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RMND5A Gene

ENSEMBL:
Gene Tree for RMND5A (if available)
TreeFam:
Gene Tree for RMND5A (if available)

Paralogs for RMND5A Gene

Paralogs for RMND5A Gene

(2) SIMAP similar genes for RMND5A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RMND5A Gene

genes like me logo Genes that share paralogs with RMND5A: view

Variants for RMND5A Gene

Sequence variations from dbSNP and Humsavar for RMND5A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1829067 -- 86,728,437(+) AAGTA(A/G)CTGGG intron-variant
rs1841382 -- 86,729,253(-) GTGCC(A/G)TGGTC intron-variant
rs1850138 -- 86,762,343(-) TTTTT(A/T)AAAGT intron-variant
rs908413 -- 86,742,174(-) GAACT(C/T)TCTGA intron-variant
rs925785 -- 86,741,565(-) CCAAC(C/T)CACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RMND5A Gene

Variant ID Type Subtype PubMed ID
nsv10063 CNV Gain 18304495
esv2421358 CNV Deletion 20811451
nsv874472 CNV Gain 21882294
esv25494 CNV Gain 19812545
nsv521780 CNV Loss 19592680
nsv458585 CNV Gain 19166990
nsv819383 CNV Loss 19587683
nsv7316 OTHER Inversion 18451855

Variation tolerance for RMND5A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RMND5A Gene

Disorders for RMND5A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RMND5A Gene - From: GeneCards

Disorder Aliases PubMed IDs
meningoencephalocele
  • encephalomeningocele
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RMND5A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RMND5A
genes like me logo Genes that share disorders with RMND5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RMND5A Gene

Publications for RMND5A Gene

  1. RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. (PMID: 17467196) Kobayashi N. … Ishigatsubo Y. (Gene 2007) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability. (PMID: 24057215) Li J. … Shao N. (Nucleic Acids Res. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RMND5A Gene

Sources for RMND5A Gene

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