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Aliases for RMND5A Gene

Aliases for RMND5A Gene

  • Required For Meiotic Nuclear Division 5 Homolog A 2 3 5
  • 44-KD Protein Coding For CTLH Motif 2 3
  • GID Complex Subunit 2 Homolog A 2 3
  • Required For Meiotic Nuclear Division 5 Homolog A (S. Cerevisiae) 2
  • C-Terminal To LisH Motif, 44 KDa 3
  • Protein RMD5 Homolog A 3
  • P44CTLH 3
  • GID2A 3
  • CTLH 3
  • GID2 3
  • RMD5 3

External Ids for RMND5A Gene

Previous GeneCards Identifiers for RMND5A Gene

  • GC02P086800
  • GC02P086947

Summaries for RMND5A Gene

GeneCards Summary for RMND5A Gene

RMND5A (Required For Meiotic Nuclear Division 5 Homolog A) is a Protein Coding gene. Diseases associated with RMND5A include Meningoencephalocele. An important paralog of this gene is RMND5B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMND5A Gene

Genomics for RMND5A Gene

Regulatory Elements for RMND5A Gene

Enhancers for RMND5A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RMND5A on UCSC Golden Path with GeneCards custom track

Promoters for RMND5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RMND5A Gene

86,720,173 bp from pter
86,778,041 bp from pter
57,869 bases
Plus strand

Genomic View for RMND5A Gene

Genes around RMND5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMND5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMND5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMND5A Gene

Proteins for RMND5A Gene

  • Protein details for RMND5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RMD5 homolog A
    Protein Accession:
    Secondary Accessions:
    • D6W5M6
    • Q6NTF0
    • Q9H6W5
    • Q9H9H2

    Protein attributes for RMND5A Gene

    391 amino acids
    Molecular mass:
    43993 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RMND5A Gene


neXtProt entry for RMND5A Gene

Post-translational modifications for RMND5A Gene

  • Ubiquitination at Lys 17, Lys 218, and Lys 365
  • Modification sites at PhosphoSitePlus

Other Protein References for RMND5A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RMND5A Gene

Domains & Families for RMND5A Gene

Suggested Antigen Peptide Sequences for RMND5A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CTLH domain.
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
genes like me logo Genes that share domains with RMND5A: view

No data available for Gene Families for RMND5A Gene

Function for RMND5A Gene

Gene Ontology (GO) - Molecular Function for RMND5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RMND5A: view

Phenotypes for RMND5A Gene

GenomeRNAi human phenotypes for RMND5A:
genes like me logo Genes that share phenotypes with RMND5A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMND5A Gene

Localization for RMND5A Gene

Subcellular locations from

Jensen Localization Image for RMND5A Gene COMPARTMENTS Subcellular localization image for RMND5A gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RMND5A Gene

Pathways & Interactions for RMND5A Gene

SuperPathways for RMND5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMND5A Gene


No data available for Pathways by source and SIGNOR curated interactions for RMND5A Gene

Drugs & Compounds for RMND5A Gene

No Compound Related Data Available

Transcripts for RMND5A Gene

mRNA/cDNA for RMND5A Gene

Unigene Clusters for RMND5A Gene

Required for meiotic nuclear division 5 homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMND5A Gene

No ASD Table

Relevant External Links for RMND5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMND5A Gene

mRNA expression in normal human tissues for RMND5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RMND5A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for RMND5A Gene

This gene is overexpressed in Liver (58.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RMND5A Gene

Protein tissue co-expression partners for RMND5A Gene

NURSA nuclear receptor signaling pathways regulating expression of RMND5A Gene:


SOURCE GeneReport for Unigene cluster for RMND5A Gene:

genes like me logo Genes that share expression patterns with RMND5A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RMND5A Gene

Orthologs for RMND5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RMND5A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RMND5A 34
  • 94.8 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia RMND5A 34
  • 96.16 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Rmnd5a 34
  • 95.06 (n)
  • 100 (a)
Rmnd5a 16
Rmnd5a 35
  • 100 (a)
(Pan troglodytes)
Mammalia RMND5A 34
  • 99.71 (n)
  • 99.71 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Rmnd5a 34
  • 94.03 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RMND5A 35
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RMND5A 35
  • 98 (a)
(Gallus gallus)
Aves LOC101751091 34
  • 84.62 (n)
  • 95.99 (a)
(Anolis carolinensis)
Reptilia RMND5A 35
  • 95 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmnd5a 34
  • 81.33 (n)
  • 93.86 (a)
Str.1465 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6044 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011892 34
  • 51.85 (n)
  • 49.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3295 34
  • 52.51 (n)
  • 48.31 (a)
CG3295 35
  • 39 (a)
(Caenorhabditis elegans)
Secernentea T07D1.2 35
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RMD5 37
RMD5 35
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G37880 34
  • 48.14 (n)
  • 38.66 (a)
(Oryza sativa)
Liliopsida Os06g0588900 34
  • 48.36 (n)
  • 38.49 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC29A3.03c 34
  • 44.58 (n)
  • 32.82 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7116 35
  • 48 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.729 34
bread mold
(Neurospora crassa)
Ascomycetes NCU00898 34
  • 45.3 (n)
  • 41.03 (a)
Species where no ortholog for RMND5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RMND5A Gene

Gene Tree for RMND5A (if available)
Gene Tree for RMND5A (if available)

Paralogs for RMND5A Gene

Paralogs for RMND5A Gene

(2) SIMAP similar genes for RMND5A Gene using alignment to 1 proteins: Pseudogenes for RMND5A Gene

genes like me logo Genes that share paralogs with RMND5A: view

Variants for RMND5A Gene

Sequence variations from dbSNP and Humsavar for RMND5A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1046613 -- 86,774,135(+) TTTTT(G/T)TTTTT utr-variant-3-prime
rs1049457 -- 86,775,905(+) ATCAT(C/T)GCTGA utr-variant-3-prime
rs1049458 -- 86,776,074(+) GGAAC(C/G)GTTTC utr-variant-3-prime
rs2203524 -- 86,739,404(+) TGTCT(C/G)TTTTT intron-variant
rs2203525 -- 86,739,485(+) AAACT(A/G)TAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RMND5A Gene

Variant ID Type Subtype PubMed ID
dgv3886n100 CNV gain 25217958
dgv714e214 CNV gain 21293372
esv2421358 CNV deletion 20811451
esv25494 CNV gain 19812545
esv3591556 CNV loss 21293372
esv3591559 CNV gain 21293372
nsv10063 CNV gain 18304495
nsv1131476 CNV deletion 24896259
nsv458585 CNV gain 19166990
nsv521780 CNV loss 19592680
nsv582373 CNV gain 21841781
nsv7316 OTHER inversion 18451855
nsv819383 CNV loss 19587683
nsv961802 CNV duplication 23825009
nsv997982 CNV gain 25217958

Variation tolerance for RMND5A Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RMND5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMND5A Gene

Disorders for RMND5A Gene

MalaCards: The human disease database

(1) MalaCards diseases for RMND5A Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • encephalomeningocele
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RMND5A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RMND5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RMND5A Gene

Publications for RMND5A Gene

  1. RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex. (PMID: 17467196) Kobayashi N. … Ishigatsubo Y. (Gene 2007) 2 3 65
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65

Products for RMND5A Gene

Sources for RMND5A Gene

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