Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RMND1 Gene

Aliases for RMND1 Gene

  • Required For Meiotic Nuclear Division 1 Homolog (S. Cerevisiae) 2 3
  • C6orf96 3 4
  • COXPD11 3 6
  • Required For Meiotic Nuclear Division Protein 1 Homolog 3
  • Chromosome 6 Open Reading Frame 96 2
  • BA351K16.3 3
  • BA351K16 3
  • RMD1 3

External Ids for RMND1 Gene

Previous Symbols for RMND1 Gene

  • C6orf96

Summaries for RMND1 Gene

Entrez Gene Summary for RMND1 Gene

  • The protein encoded by this gene belongs to the evolutionary conserved sif2 family of proteins that share the DUF155 domain in common. This protein is thought to be localized in the mitochondria and involved in mitochondrial translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-11. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for RMND1 Gene

RMND1 (Required For Meiotic Nuclear Division 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with RMND1 include combined oxidative phosphorylation deficiency 11 and combined oxidative phosphorylation deficiency.

UniProtKB/Swiss-Prot for RMND1 Gene

  • Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMND1 Gene

Genomics for RMND1 Gene

Genomic Location for RMND1 Gene

Start:
151,404,762 bp from pter
End:
151,452,181 bp from pter
Size:
47,420 bases
Orientation:
Minus strand

Genomic View for RMND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RMND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMND1 Gene

Regulatory Elements for RMND1 Gene

Proteins for RMND1 Gene

  • Protein details for RMND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWS8-RMND1_HUMAN
    Recommended name:
    Required for meiotic nuclear division protein 1 homolog
    Protein Accession:
    Q9NWS8
    Secondary Accessions:
    • A8K8H4
    • Q0VDG6
    • Q5SZ48
    • Q5SZ83
    • Q6NSC5
    • Q96EN7

    Protein attributes for RMND1 Gene

    Size:
    449 amino acids
    Molecular mass:
    51604 Da
    Quaternary structure:
    • May form homopolymer

    Alternative splice isoforms for RMND1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RMND1 Gene

Proteomics data for RMND1 Gene at MOPED

Post-translational modifications for RMND1 Gene

No Post-translational modifications

Other Protein References for RMND1 Gene

No data available for DME Specific Peptides for RMND1 Gene

Domains for RMND1 Gene

Protein Domains for RMND1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RMND1_HUMAN
Family:
  • Belongs to the RMD1/sif2 family.:
    • Q9NWS8
genes like me logo Genes that share domains with RMND1: view

No data available for Gene Families for RMND1 Gene

Function for RMND1 Gene

Molecular function for RMND1 Gene

UniProtKB/Swiss-Prot Function: Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome.

Gene Ontology (GO) - Molecular Function for RMND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RMND1: view

Phenotypes for RMND1 Gene

GenomeRNAi human phenotypes for RMND1:
genes like me logo Genes that share phenotypes with RMND1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RMND1 Gene

Localization for RMND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMND1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RMND1 Gene COMPARTMENTS Subcellular localization image for RMND1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for RMND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with RMND1: view

Pathways for RMND1 Gene

SuperPathways for RMND1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with RMND1: view

No data available for Pathways by source for RMND1 Gene

Transcripts for RMND1 Gene

Unigene Clusters for RMND1 Gene

Required for meiotic nuclear division 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RMND1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: - -

Relevant External Links for RMND1 Gene

GeneLoc Exon Structure for
RMND1
ECgene alternative splicing isoforms for
RMND1

Expression for RMND1 Gene

mRNA expression in normal human tissues for RMND1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMND1 Gene

SOURCE GeneReport for Unigene cluster for RMND1 Gene Hs.486835

genes like me logo Genes that share expressions with RMND1: view

Orthologs for RMND1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RMND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RMND1 36
  • 99.55 (n)
  • 99.33 (a)
RMND1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RMND1 36
  • 87.65 (n)
  • 86.61 (a)
RMND1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RMND1 36
  • 88.27 (n)
  • 87.08 (a)
RMND1 37
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rmnd1 36
  • 83.07 (n)
  • 82.18 (a)
Rmnd1 16
Rmnd1 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RMND1 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RMND1 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rmnd1 36
  • 81.37 (n)
  • 80.18 (a)
chicken
(Gallus gallus)
Aves RMND1 36
  • 68.24 (n)
  • 63.15 (a)
RMND1 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RMND1 37
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rmnd1 36
  • 69.24 (n)
  • 71.14 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17498 36
rmnd1 36
  • 63.52 (n)
  • 60.2 (a)
rmnd1 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003903 36
  • 50.81 (n)
  • 47.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11679 36
  • 52.33 (n)
  • 43.65 (a)
CG11679 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK1010.2 36
  • 43.42 (n)
  • 31.91 (a)
ZK1010.2 37
  • 27 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL122C 36
  • 44.15 (n)
  • 32.08 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 22 (a)
OneToOne
-- 39
YDR282C 36
  • 44.52 (n)
  • 26.91 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11165g 36
  • 43.62 (n)
  • 31.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02271 36
  • 45.89 (n)
  • 37.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for RMND1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMND1 Gene

ENSEMBL:
Gene Tree for RMND1 (if available)
TreeFam:
Gene Tree for RMND1 (if available)

Paralogs for RMND1 Gene

Pseudogenes.org Pseudogenes for RMND1 Gene

genes like me logo Genes that share paralogs with RMND1: view

No data available for Paralogs for RMND1 Gene

Variants for RMND1 Gene

Sequence variations from dbSNP and Humsavar for RMND1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1017869 -- 151,431,634(+) tgtgg(C/G)tattg intron-variant
rs1017870 -- 151,431,668(+) aaact(G/T)agatg intron-variant
rs1065310 -- 151,405,165(-) CGGCC(C/G)GGCGC utr-variant-3-prime
rs1564742 -- 151,427,561(+) TTCTA(A/G)AACTT reference, synonymous-codon
rs2046371 -- 151,433,609(+) aagaa(A/G)tatta intron-variant

Relevant External Links for RMND1 Gene

HapMap Linkage Disequilibrium report
RMND1
Human Gene Mutation Database (HGMD)
RMND1

No data available for Structural Variations from Database of Genomic Variants (DGV) for RMND1 Gene

Disorders for RMND1 Gene

(1) OMIM Diseases for RMND1 Gene (614917)

UniProtKB/Swiss-Prot

RMND1_HUMAN
  • Combined oxidative phosphorylation deficiency 11 (COXPD11) [MIM:614922]: A severe, multisystemic, autosomal recessive, disorder characterized by deficiencies of multiple mitochondrial respiratory enzymes leading to neonatal hypotonia and lactic acidosis. Affected individuals may have respiratory insufficiency, foot deformities, or seizures. {ECO:0000269 PubMed:23022098, ECO:0000269 PubMed:23022099}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RMND1

Genetic Association Database (GAD)
RMND1
Human Genome Epidemiology (HuGE) Navigator
RMND1
genes like me logo Genes that share disorders with RMND1: view

Publications for RMND1 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for RMND1 Gene

Sources for RMND1 Gene

Back to Top

Content