RMI2 Gene
protein-coding GIFtS: 43
GCID: GC16P011343
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RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae)(Previous name: chromosome 16 open reading frame 75 )
(Previous symbol: C16orf75)
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Aliases
for RMI2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RMI2, RecQ Mediated Genome Instability 2, Homolog (S. Cerevisiae)1 2 | | MGC246651 | | BLAP181 2 3 5 | | Chromosome 16 Open Reading Frame 751 | | C16orf751 2 3 5 | | RecQ-Mediated Genome Instability 2, S. Cerevisiae, Homolog Of2 | | BLM-Associated Protein Of 18 KDa2 3 | | RecQ-Mediated Genome Instability Protein 22 | | HRMI21 | | |
Export aliases for RMI2 gene to outside databasesPrevious GC identifer: GC16P011411 |
Summaries
for RMI2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RMI2:
RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependentDNA repair and is essential for genome stability (Xu et al., 2008 (PubMed 18923082)).(supplied by OMIM, Nov 2008)
UniProtKB/Swiss-Prot: RMI2_HUMAN, Q96E14Function: Essential component of the RMI complex, a complex that plays an important role in the processing ofhomologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essentialfor the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required totarget BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM
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Genomic Views
for RMI2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RMI2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RMI2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RMI2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.13 Ensembl cytogenetic band: 16p13.13 HGNC cytogenetic band: 16p13.13RMI2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P011343: view genomic region
(about GC identifiers)
Start:
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11,343,476 bp from pter |
End:
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11,445,619 bp from pter |
Size:
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102,144 bases |
Orientation:
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plus strand |
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Proteins
for RMI2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RMI2_HUMAN, Q96E14 (See
protein sequence)Recommended Name: RecQ-mediated genome instability protein 2 Size: 147 amino acids; 15865 Da
Subunit: Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM
Subcellular location: Nucleus. Note=Colocalizes with BLM at nuclear DNA repair foci
3 PDB 3D structures from  and Proteopedia  for RMI2:3MXN (3D)
3NBH (3D)
4DAY (3D)
Secondary accessions: B3KVZ6 Q49AE2 Q8TBL0Alternative splicing: 2 isoforms: Q96E14-1 Q96E14-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RMI2: NX_Q96E14
Post-translational modifications:
Phosphorylated during mitosis1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96E14
RMI2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689521.1
ENSEMBL proteins: ENSP00000461206 ENSP00000310356 ENSP00000459601 ENSP00000371241
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RMI2 for ontologies About GeneDecksing
RMI2 Antibody Products:
Assay Products for RMI2: |
Protein
Domains /
Families
for RMI2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96E14 UniProtKB/Swiss-Prot: RMI2_HUMAN, Q96E14Similarity: Belongs to the RMI2 familySimilarity: Contains 1 OB DNA-binding domain |
Function
for RMI2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RMI2_HUMAN, Q96E14Function: Essential component of the RMI complex, a complex that plays an important role in the processing ofhomologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essentialfor the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required totarget BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RMI2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RMI2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0003677 | DNA binding |
IEA | -- |
RMI2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RMI2:
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Pathways & Interactions
for RMI2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RMI2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/10 Interacting proteins for RMI2 (Q96E142, 3 ENSP000003103564) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006260 | DNA replication |
IEA | -- |
RMI2 for ontologies About GeneDecksing
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Drugs & Compounds
for RMI2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RMI2
Search CenterWatch for drugs/clinical trials and news about RMI2
|
Transcripts
for RMI2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RMI2 gene: NM_152308.1 Unigene Cluster for RMI2: RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae) Hs.347524 [show with all ESTs]Unigene Representative Sequence: BC0393616 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000573910 ENST00000572173(uc002daq.1) ENST00000572992 ENST00000312499(uc002daw.1)
ENST00000576027 ENST00000381820
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RMI2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RMI2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for RMI2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RMI2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RMI2 |
Additional cDNA sequence: AK123764.1 BC013040.2 BC022427.1 BC031016.1 BC039361.1 6 DOTS entries: DT.87016475 DT.100835708 DT.100775947 DT.102825488 DT.101979909 DT.102825489 24/102 AceView cDNA sequences (see all 102): BC039361 CR593562 CR620636 BU169567 BM474434 CB106480 CR611079 BI829322 AI075033 CR626010 AI597613 BU845454 CR626823 CR598957 CR592375 AI817803 BU509119 AI675722 AK123764 AI091904 BE219713 BE396569 BQ021959 BU621994
GeneLoc Exon Structure
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Expression
for RMI2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RMI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGTAGACT
About this image
See RMI2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RMI2
SOURCE GeneReport for Unigene cluster: Hs.347524
SABiosciences Custom PCR Arrays for RMI2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RMI2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RMI2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RMI2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RMI2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RMI2 |
Orthologs
for RMI2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for RMI2 gene from 4/9 species (see all 9) About this table
ENSEMBL Gene Tree for RMI2 (if available)
TreeFam Gene Tree for RMI2 (if available) |
Paralogs
for RMI2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RMI2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RMI2 (11343476 - 11445619 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RMI2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RMI2 |
|
Disorders
/ Diseases
for RMI2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RMI2 for disorders About GeneDecksing
OMIM gene information: 612426
OMIM disorders: --
4  diseases for RMI2: About MalaCardsbloom syndrome fanconi's anemia crohn's disease anemia
Export disorders for RMI2 gene to outside databases
|
Publications
for RMI2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RMI2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with RMI2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. (PubMed id 18923083)1, 2, 3 Singh T.R.... Meetei A.R. (2008)
- RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. (PubMed id 18923082)1, 2 Xu D.... Wang W. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Crystal structures of RMI1 and RMI2, two OB-fold regu latory subunits of the BLM complex. (PubMed id 20826342)1 Wang F....Lei M. (2010)
- Analysis of SNPs with an effect on gene expression id entifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease. (PubMed id 20601676)1 Fransen K....Weersma R.K. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. (PubMed id 20347429)1 Singh T.R....Meetei A.R. (2010)
- FANCM connects the genome instability disorders Bloom 's Syndrome and Fanconi Anemia. (PubMed id 20064461)1 Deans A.J. and West S.C. (2009)
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External Searches for RMI2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RMI2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RMI2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RMI2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RMI2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RMI2 gene:
Search GeneIP for patents involving RMI2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RMI2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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 | | | RMI2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RMI2 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RMI2 |
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