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Aliases for RMI2 Gene

Aliases for RMI2 Gene

  • RecQ Mediated Genome Instability 2 2 3
  • C16orf75 3 4 6
  • BLAP18 3 4 6
  • BLM-Associated Protein Of 18 KDa 3 4
  • RMI2, RecQ Mediated Genome Instability 2, Homolog (S. Cerevisiae) 2
  • RMI2, RecQ Mediated Genome Instability 2, Homolog 3
  • RecQ-Mediated Genome Instability Protein 2 3
  • Chromosome 16 Open Reading Frame 75 2
  • HRMI2 4

External Ids for RMI2 Gene

Previous HGNC Symbols for RMI2 Gene

  • C16orf75

Previous GeneCards Identifiers for RMI2 Gene

  • GC16P011411

Summaries for RMI2 Gene

Entrez Gene Summary for RMI2 Gene

  • RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]

GeneCards Summary for RMI2 Gene

RMI2 (RecQ Mediated Genome Instability 2) is a Protein Coding gene. Among its related pathways are Fanconi anemia pathway (KEGG).

UniProtKB/Swiss-Prot for RMI2 Gene

  • Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMI2 Gene

Genomics for RMI2 Gene

Genomic Location for RMI2 Gene

Start:
11,249,619 bp from pter
End:
11,351,762 bp from pter
Size:
102,144 bases
Orientation:
Plus strand

Genomic View for RMI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RMI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMI2 Gene

No data available for Regulatory Elements for RMI2 Gene

Proteins for RMI2 Gene

  • Protein details for RMI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E14-RMI2_HUMAN
    Recommended name:
    RecQ-mediated genome instability protein 2
    Protein Accession:
    Q96E14
    Secondary Accessions:
    • B3KVZ6
    • Q49AE2
    • Q8TBL0

    Protein attributes for RMI2 Gene

    Size:
    147 amino acids
    Molecular mass:
    15865 Da
    Quaternary structure:
    • Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM.

    Three dimensional structures from OCA and Proteopedia for RMI2 Gene

    Alternative splice isoforms for RMI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RMI2 Gene

Proteomics data for RMI2 Gene at MOPED

Post-translational modifications for RMI2 Gene

Other Protein References for RMI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RMI2 Gene

Domains for RMI2 Gene

Protein Domains for RMI2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for RMI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96E14

UniProtKB/Swiss-Prot:

RMI2_HUMAN :
  • Q96E14
Domain:
  • Contains 1 OB DNA-binding domain.
Family:
  • Belongs to the RMI2 family.
genes like me logo Genes that share domains with RMI2: view

No data available for Gene Families for RMI2 Gene

Function for RMI2 Gene

Molecular function for RMI2 Gene

UniProtKB/Swiss-Prot Function:
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. The complex is therefore essential for the stability, localization, and function of complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.

Gene Ontology (GO) - Molecular Function for RMI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with RMI2: view

Phenotypes for RMI2 Gene

GenomeRNAi human phenotypes for RMI2:
genes like me logo Genes that share phenotypes with RMI2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RMI2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RMI2 Gene

Localization for RMI2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMI2 Gene

Nucleus. Note=Colocalizes with BLM at nuclear DNA repair foci.

Gene Ontology (GO) - Cellular Components for RMI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with RMI2: view

No data available for Subcellular locations from COMPARTMENTS for RMI2 Gene

Pathways for RMI2 Gene

SuperPathways for RMI2 Gene

Superpath Contained pathways
1 Fanconi anemia pathway (KEGG)
genes like me logo Genes that share pathways with RMI2: view

Pathways by source for RMI2 Gene

1 KEGG pathway for RMI2 Gene

Gene Ontology (GO) - Biological Process for RMI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
genes like me logo Genes that share ontologies with RMI2: view

Transcripts for RMI2 Gene

Unigene Clusters for RMI2 Gene

RMI2, RecQ mediated genome instability 2, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RMI2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMI2 Gene

No ASD Table

Relevant External Links for RMI2 Gene

GeneLoc Exon Structure for
RMI2
ECgene alternative splicing isoforms for
RMI2

Expression for RMI2 Gene

mRNA expression in normal human tissues for RMI2 Gene

mRNA differential expression in normal tissues according to GTEx for RMI2 Gene

This gene is overexpressed in Testis (4.7).

Protein differential expression in normal tissues for RMI2 Gene

This gene is overexpressed in Fetal ovary (61.3) and Fetal heart (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMI2 Gene

SOURCE GeneReport for Unigene cluster for RMI2 Gene Hs.347524

genes like me logo Genes that share expressions with RMI2: view

Expression partners for RMI2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RMI2 Gene

Orthologs for RMI2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RMI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RMI2 35
  • 87.21 (n)
  • 84.93 (a)
RMI2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RMI2 35
  • 89.9 (n)
  • 90.15 (a)
RMI2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rmi2 35
  • 84.93 (n)
  • 84.93 (a)
Rmi2 16
Rmi2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rmi2 35
  • 83.56 (n)
  • 86.3 (a)
oppossum
(Monodelphis domestica)
Mammalia RMI2 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RMI2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves RMI2 35
  • 71.61 (n)
  • 69.53 (a)
RMI2 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RMI2 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rmi2 35
  • 57.04 (n)
  • 52.82 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC563218 35
  • 59.17 (n)
  • 55.04 (a)
RMI2 36
  • 47 (a)
OneToOne
Species with no ortholog for RMI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RMI2 Gene

ENSEMBL:
Gene Tree for RMI2 (if available)
TreeFam:
Gene Tree for RMI2 (if available)

Paralogs for RMI2 Gene

No data available for Paralogs for RMI2 Gene

Variants for RMI2 Gene

Sequence variations from dbSNP and Humsavar for RMI2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7626 -- 11,351,739(-) TTAGA(A/G)GTAGA utr-variant-3-prime
rs918737 -- 11,345,782(+) GGCCT(C/T)ACCGG intron-variant
rs918738 -- 11,345,822(+) GTTGC(C/G)GAGGC intron-variant
rs918739 -- 11,345,876(+) GTCTG(G/T)CCCTC intron-variant
rs1541700 -- 11,351,961(-) ggaat(A/G)aagcc downstream-variant-500B

Relevant External Links for RMI2 Gene

HapMap Linkage Disequilibrium report
RMI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RMI2 Gene

Disorders for RMI2 Gene

No disorders were found for RMI2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RMI2 Gene

Publications for RMI2 Gene

  1. BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome. (PMID: 18923083) Singh T.R. … Meetei A.R. (Genes Dev. 2008) 2 3 4
  2. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. (PMID: 18923082) Xu D. … Wang W. (Genes Dev. 2008) 3 4
  3. Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome. (PMID: 20826341) Hoadley K.A. … Keck J.L. (Structure 2010) 2 3
  4. Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. (PMID: 20826342) Wang F. … Lei M. (Structure 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for RMI2 Gene

Sources for RMI2 Gene

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