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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RMI1 Gene

protein-coding   GIFtS: 56
GCID: GC09P086595

RecQ Mediated Genome Instability 1

(Previous names: chromosome 9 open reading frame 76, RMI1, RecQ mediated...)
(Previous symbol: C9orf76)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RecQ Mediated Genome Instability 11 2     RP11-346I8.12
C9orf761 2 3 5     BLM-Associated Polypeptide, 75 KDa2
BLAP752 3 5     BLM-Associated Protein 75 KDa2
FAAP752 3     Homolog Of Yeast RecQ-Mediated Genome Instability 1 (RMI1)2
75 KDa1     RecQ-Mediated Genome Instability Protein 12
BLM-Associated Polypeptide1     RMI1, RecQ Mediated Genome Instability 1, Homolog2
Chromosome 9 Open Reading Frame 761     BLM-Associated Protein Of 75 KDa3
RMI1, RecQ Mediated Genome Instability 1, Homolog (S. Cerevisiae)1     RMI25

External Ids:    HGNC: 257641   Entrez Gene: 800102   Ensembl: ENSG000001789667   OMIM: 6104045   UniProtKB: Q9H9A73   

Export aliases for RMI1 gene to outside databases

Previous GC identifers: GC09P085786 GC09P056421


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RMI1 Gene:
RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday
junctions (Raynard et al., 2006 (PubMed 16595695)).(supplied by OMIM, Mar 2008)

GeneCards Summary for RMI1 Gene: 
RMI1 (RecQ mediated genome instability 1) is a protein-coding gene. Diseases associated with RMI1 include bloom syndrome, and fanconi's anemia. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: RMI1_HUMAN, Q9H9A7
Function: Essential component of the RMI complex, a complex that plays an important role in the processing of
homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to
double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation
during mitosis. Within the BLM complex, required for BLM and TOP3A stability

Gene Wiki entry for RMI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RMI1 gene promoter:
         Nkx3-1   Nkx3-1 v1   Nkx2-5   Nkx3-1 v2   MEF-2A   AREB6   Nkx6-1   aMEF-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRMI1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RMI1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RMI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.32   Ensembl cytogenetic band:  9q21.32   HGNC cytogenetic band: 9q22.1

RMI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RMI1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P086595:  view genomic region     (about GC identifiers)

Start:
86,595,626 bp from pter      End:
86,618,989 bp from pter
Size:
23,364 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RMI1_HUMAN, Q9H9A7 (See protein sequence)
Recommended Name: RecQ-mediated genome instability protein 1  
Size: 625 amino acids; 70144 Da
Subunit: Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with
BLM. Directly interacts with RMI2, BLM and TOP3A. May bind DHJ
Subcellular location: Nucleus. Note=Forms foci in response to DNA damage
Sequence caution: Sequence=AAH20606.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH32494.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH39999.1; Type=Frameshift; Positions=375; Sequence=AAH39999.1; Type=Frameshift;
Positions=377, 444; Sequence=AAH53549.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH64937.1; Type=Frameshift; Positions=444, 615; Sequence=AAH64937.1; Type=Frameshift;
Positions=377, 444; Sequence=CAI13575.1; Type=Erroneous gene model prediction;
4 PDB 3D structures from and Proteopedia for RMI1:
3MXN (3D)        3NBH (3D)        3NBI (3D)        4DAY (3D)    
Secondary accessions: Q05BX1 Q05CW3 Q5SQG8 Q5SQG9 Q6P1Q4 Q6PI89 Q7Z6L6

Explore the universe of human proteins at neXtProt for RMI1: NX_Q9H9A7

Explore proteomics data for RMI1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H9A7

  • RMI1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RMI1 Protein Expression
    REFSEQ proteins: NP_079221.2  
    ENSEMBL proteins: 
     ENSP00000402433   ENSP00000317039  

    Human Recombinant Protein Products for RMI1: 
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    Novus Biologicals RMI1 Protein
    Novus Biologicals RMI1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RMI1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    RMI1 for ontologies           About GeneDecksing



    RMI1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for RMI1 
    Cloud-Clone Corp. CLIAs for RMI1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013894 DUF1767

    Graphical View of Domain Structure for InterPro Entry Q9H9A7

    ProtoNet protein and cluster: Q9H9A7

    2 Blocks protein domains:
    IPB004365 OB-fold nucleic acid binding domain
    IPB013894 Domain of unknown function DUF1767


    UniProtKB/Swiss-Prot: RMI1_HUMAN, Q9H9A7
    Similarity: Belongs to the RMI1 family


    RMI1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RMI1_HUMAN, Q9H9A7
    Function: Essential component of the RMI complex, a complex that plays an important role in the processing of
    homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to
    double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation
    during mitosis. Within the BLM complex, required for BLM and TOP3A stability

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15775963
         
    RMI1 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rmi1):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  liver/biliary system 
     mortality/aging 

    RMI1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RMI1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RMI1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RMI1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RMI1 

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate RMI1 (see all 9):
    hsa-miR-607 hsa-miR-429 hsa-miR-513a-3p hsa-miR-545 hsa-miR-570 hsa-miR-33a* hsa-miR-200c hsa-miR-362-5p
    SwitchGear 3'UTR luciferase reporter plasmidRMI1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RMI1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RMI1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Fanconi anemia pathway
    Fanconi anemia pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for RMI1):
        Fanconi anemia pathway


    RMI1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RMI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/28 Interacting proteins for RMI1 (Q9H9A71, 2, 3 ENSP000003170394) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BLMP541321, 2, 3, ENSP000003472324EBI-621339,EBI-621372 MINT-8048980 MINT-8049128 MINT-8048995 MINT-8049010 MINT-8048961 MINT-8049038 I2D: score=2 STRING: ENSP00000347232
    RMI2Q96E142, 3, ENSP000003103564MINT-8048980 MINT-8048995 MINT-8049010 MINT-8048961 MINT-8049038 I2D: score=1 STRING: ENSP00000310356
    HSPA13P487232, 3, ENSP000002856674MINT-8258533 I2D: score=2 STRING: ENSP00000285667
    NR1H2P550552, 3MINT-8263907 I2D: score=2 
    PFDN1O609252, 3MINT-8266018 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--

    RMI1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RMI1

    Search CenterWatch for drugs/clinical trials and news about RMI1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RMI1 gene: 
    NM_024945.2  

    Unigene Cluster for RMI1:

    RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
    Hs.726327  [show with all ESTs]
    Unigene Representative Sequence: NM_024945
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445877 ENST00000325875(uc004anq.4 uc004anr.4 uc004anp.4 uc004ans.4)

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate RMI1 (see all 9):
    hsa-miR-607 hsa-miR-429 hsa-miR-513a-3p hsa-miR-545 hsa-miR-570 hsa-miR-33a* hsa-miR-200c hsa-miR-362-5p
    SwitchGear 3'UTR luciferase reporter plasmidRMI1 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RMI1
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RMI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RMI1
    Sirion Biotech Customized lentivirus for stable overexpression of RMI1 
                         Customized lentivirus expression plasmids for stable overexpression of RMI1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RMI1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RMI1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RMI1

    Additional mRNA sequence: 

    AJ420435.1 AK022950.1 BC020606.1 BC032494.1 BC039999.2 BC044571.1 BC053549.1 BC064937.1 

    12 DOTS entries:

    DT.91918649  DT.100637986  DT.111754  DT.95233494  DT.40308410  DT.92424958  DT.121167974  DT.95255662 
    DT.102823610  DT.95374029  DT.121167916  DT.99986476 

    24/129 AceView cDNA sequences (see all 129):

    T34975 BX395214 BC020606 BU152925 AA306479 AA805442 AI632071 BC053549 
    AA236532 Z39901 BE328766 AI653609 AA830081 BM661843 AA814239 AA613327 
    AW615100 CB306112 AA449116 BU429327 AW955256 AA593199 BC032494 AI377322 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for RMI1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:                                      -                                             
    SP2:                          -           -     -                                       
    SP3:                                      -     -                                       
    SP4:                          -     -     -     -                                       
    SP5:                                -     -     -                                       


    ECgene alternative splicing isoforms for RMI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RMI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGAGCTTG
    RMI1 Expression
    About this image


    See RMI1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RMI1

    SOURCE GeneReport for Unigene cluster: Hs.726327
        SABiosciences Custom PCR Arrays for RMI1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RMI1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RMI1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rmi11 , 5 RMI1, RecQ mediated genome instability 1, homolog (S. more1, 5 80.51(n)1
    73.62(a)1
      13 (31.05 cM)5
    743861  NM_001168248.11  NP_001161720.11 
     584025975 
    chicken
    (Gallus gallus)
    Aves RMI11 RMI1, RecQ mediated genome instability 1, homolog (S. more 62.72(n)
    56.93(a)
      431669  NM_001031612.1  NP_001026783.1 
    lizard
    (Anolis carolinensis)
    Reptilia RMI16
    Uncharacterized protein
    51(a)
    1 ↔ 1
    2(42550953-42552662)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558822 hypothetical protein MGC55882 71.33(n)   393149  BC045482.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T07C12.126
    Protein T07C12.12
    20(a)
    1 ↔ 1
    V(9927782-9930775)


    ENSEMBL Gene Tree for RMI1 (if available)
    TreeFam Gene Tree for RMI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/465 SNPs in RMI1 are shown (see all 465)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1403211761,2
    C--86597576(+) AGACCA/CTGTCT 1 -- int10--------
    rs2014107731,2
    --86597605(+) AAAAA-/CAAAAA 1 -- int10--------
    rs1821229581,2
    --86597606(+) AAAAAA/CAAAAA 1 -- int10--------
    rs1123689741,2
    F--86597627(+) CCAGTG/TTCATT 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs1864438531,2
    --86597633(+) TCATTA/GTCCAG 1 -- int10--------
    rs1503373061,2
    --86597711(+) CCCCCA/CATTTG 1 -- int10--------
    rs2968921,2
    C,F,O,A,H--86597806(-) CTTAAC/TTTCAA 1 -- int120Minor allele frequency- N:0.00NS EA NA WA 1418
    rs1918655551,2
    --86597851(+) TTCAAC/GAACTT 1 -- int10--------
    rs3722986161,2
    C--86597867(+) TACATG/TCATTG 1 -- int10--------
    rs1837284511,2
    --86598015(+) GCTGCA/GTTATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RMI1 (86595626 - 86618989 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RMI1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831644CNV Gain17160897
    nsv893514CNV Gain21882294
    dgv2394e1CNV Complex17122850
    nsv436717OTHER Inversion17901297


    Human Gene Mutation Database (HGMD): RMI1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610404    OMIM disorders: --

    7 diseases for RMI1:    About MalaCards
    bloom syndrome    fanconi's anemia    albinism    anemia
    colorectal cancer    melanoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for RMI1:
    Bloom syndrome

    RMI1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RMI1
    Human Genome Epidemiology (HuGE) Navigator: RMI1 (4 documents)

    Export disorders for RMI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RMI1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RMI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. (PubMed id 15775963)1, 2, 3 Yin J.... Wang W. (2005)
    2. Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study. (PubMed id 19432957)1, 4, 9 Broberg K....HAPglund M. (2009)
    3. Colorectal cancer and polymorphisms in DNA repair gen es WRN, RMI1 and BLM. (PubMed id 19945966)1, 4, 9 Frank B....Brenner H. (2010)
    4. Structure and cellular roles of the RMI core complex f rom the bloom syndrome dissolvasome. (PubMed id 20826341)1, 3 Hoadley K.A....Keck J.L. (2010)
    5. Predisposition for TMPRSS2-ERG fusion in prostate can cer by variants in DNA repair genes. (PubMed id 19861517)1, 4 Luedeke M....Maier C. (2009)
    6. Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma. (PubMed id 17900800)1, 4 Broberg K....Olsson H. (2007)
    7. BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. (PubMed id 16537486)1, 2 Wu L.... Hickson I.D. (2006)
    8. A double Holliday junction dissolvasome comprising BLM, topoisomerase III alpha, and BLAP75. (PubMed id 16595695)1, 2 Raynard S.... Sung P. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80010 HGNC: 25764 AceView: C9orf76 Ensembl:ENSG00000178966 euGenes: HUgn80010
    ECgene: RMI1 Kegg: 80010 H-InvDB: RMI1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RMI1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RMI1 gene:
    Search GeneIP for patents involving RMI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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