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Aliases for RMDN3 Gene

Aliases for RMDN3 Gene

  • Regulator Of Microtubule Dynamics 3 2 3
  • Ptpip51 3 4 6
  • FAM82A2 3 4 6
  • FAM82C 3 4 6
  • Protein Tyrosine Phosphatase-Interacting Protein 51 3 4
  • Family With Sequence Similarity 82, Member A2 2 3
  • TCPTP-Interacting Protein 51 3 4
  • Cerebral Protein 10 3 4
  • RMD-3 3 4
  • RMD3 3 6
  • Family With Sequence Similarity 82, Member C 3
  • Regulator Of Microtubule Dynamics Protein 3 3
  • Microtubule-Associated Protein 3
  • Protein FAM82A2 4
  • Protein FAM82C 4
  • HRMD-3 4

External Ids for RMDN3 Gene

Previous Symbols for RMDN3 Gene

  • FAM82C
  • FAM82A2

Summaries for RMDN3 Gene

GeneCards Summary for RMDN3 Gene

RMDN3 (Regulator Of Microtubule Dynamics 3) is a Protein Coding gene. An important paralog of this gene is RMDN2.

UniProtKB/Swiss-Prot for RMDN3 Gene

  • Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN3 Gene

Genomics for RMDN3 Gene

Genomic Location for RMDN3 Gene

Start:
40,735,884 bp from pter
End:
40,755,851 bp from pter
Size:
19,968 bases
Orientation:
Minus strand

Genomic View for RMDN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RMDN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN3 Gene

No data available for Regulatory Elements for RMDN3 Gene

Proteins for RMDN3 Gene

  • Protein details for RMDN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96TC7-RMD3_HUMAN
    Recommended name:
    Regulator of microtubule dynamics protein 3
    Protein Accession:
    Q96TC7
    Secondary Accessions:
    • A9UMZ9
    • B3KRR3
    • Q6ZWE9
    • Q96H23
    • Q96SD6
    • Q9H6G1
    • Q9NVQ6

    Protein attributes for RMDN3 Gene

    Size:
    470 amino acids
    Molecular mass:
    52118 Da
    Quaternary structure:
    • Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.
    SequenceCaution:
    • Sequence=BAB15298.1; Type=Erroneous termination; Positions=453; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC85554.1; Type=Frameshift; Positions=383; Evidence={ECO:0000305};

    Alternative splice isoforms for RMDN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RMDN3 Gene

Proteomics data for RMDN3 Gene at MOPED

Post-translational modifications for RMDN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RMDN3 Gene

No data available for DME Specific Peptides for RMDN3 Gene

Domains for RMDN3 Gene

Protein Domains for RMDN3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RMD3_HUMAN
Domain:
  • The transmembrane region is required for mitochondrial localization:
    • Q96TC7
Family:
  • Belongs to the RMDN family.:
    • Q96TC7
genes like me logo Genes that share domains with RMDN3: view

No data available for Gene Families for RMDN3 Gene

Function for RMDN3 Gene

Molecular function for RMDN3 Gene

UniProtKB/Swiss-Prot Function: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
UniProtKB/Swiss-Prot Induction: By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D(3).

Gene Ontology (GO) - Molecular Function for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18771726
genes like me logo Genes that share ontologies with RMDN3: view

Phenotypes for RMDN3 Gene

MGI mutant phenotypes for RMDN3:
inferred from 1 alleles
GenomeRNAi human phenotypes for RMDN3:
genes like me logo Genes that share phenotypes with RMDN3: view

miRNA for RMDN3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RMDN3 Gene

Localization for RMDN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN3 Gene

Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Gene Ontology (GO) - Cellular Components for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IDA 22131369
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with RMDN3: view

Pathways for RMDN3 Gene

SuperPathways for RMDN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IMP 22131369
GO:0006915 apoptotic process IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RMDN3: view

No data available for Pathways by source for RMDN3 Gene

Transcripts for RMDN3 Gene

Unigene Clusters for RMDN3 Gene

Regulator of microtubule dynamics 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6:
SP7: -
SP8: - - - -
SP9: - - - - - -
SP10: - -
SP11:

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RMDN3 Gene

GeneLoc Exon Structure for
RMDN3
ECgene alternative splicing isoforms for
RMDN3

Expression for RMDN3 Gene

mRNA expression in normal human tissues for RMDN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMDN3 Gene

SOURCE GeneReport for Unigene cluster for RMDN3 Gene Hs.511067

mRNA Expression by UniProt/SwissProt for RMDN3 Gene

Q96TC7-RMD3_HUMAN
Tissue specificity: Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
genes like me logo Genes that share expressions with RMDN3: view

Orthologs for RMDN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM82A2 36
  • 99.86 (n)
  • 100 (a)
FAM82A2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RMDN3 36
  • 87.79 (n)
  • 86.51 (a)
RMDN3 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM82A2 36
  • 89.72 (n)
  • 88.72 (a)
RMDN3 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rmdn3 36
  • 84.76 (n)
  • 85.04 (a)
Rmdn3 16
Rmdn3 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RMDN3 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RMDN3 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rmdn3 36
  • 85.54 (n)
  • 86.75 (a)
chicken
(Gallus gallus)
Aves FAM82A2 36
  • 66.3 (n)
  • 63.36 (a)
RMDN3 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RMDN3 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn3 36
  • 59.55 (n)
  • 56.59 (a)
zebrafish
(Danio rerio)
Actinopterygii rmdn3 36
  • 53.32 (n)
  • 46.22 (a)
rmdn3 37
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16C8.18 37
  • 21 (a)
ManyToMany
rmd-1 37
  • 23 (a)
ManyToMany
rmd-2 37
  • 22 (a)
ManyToMany
rmd-3 37
  • 26 (a)
ManyToMany
rmd-4 37
  • 27 (a)
ManyToMany
rmd-5 37
  • 21 (a)
ManyToMany
rmd-6 37
  • 27 (a)
ManyToMany
sup-35 37
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToMany
Species with no ortholog for RMDN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN3 Gene

ENSEMBL:
Gene Tree for RMDN3 (if available)
TreeFam:
Gene Tree for RMDN3 (if available)

Paralogs for RMDN3 Gene

Paralogs for RMDN3 Gene

Selected SIMAP similar genes for RMDN3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RMDN3: view

Variants for RMDN3 Gene

Sequence variations from dbSNP and Humsavar for RMDN3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs752012 -- 40,752,692(+) AGTTA(C/T)TAAGA intron-variant
rs1043986 -- 40,736,507(-) TGCCA(C/T)TATTT utr-variant-3-prime
rs1128704 -- 40,742,283(-) TGCCT(A/G)TAATC intron-variant
rs1128707 -- 40,742,235(-) agccc(A/G)ggagt intron-variant
rs1128708 -- 40,742,221(-) agact(A/G)gcctg intron-variant

Relevant External Links for RMDN3 Gene

HapMap Linkage Disequilibrium report
RMDN3

No data available for Structural Variations from Database of Genomic Variants (DGV) for RMDN3 Gene

Disorders for RMDN3 Gene

No disorders were found for RMDN3 Gene.

No data available for UniProtKB/Swiss-Prot for RMDN3 Gene

Publications for RMDN3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The novel protein PTPIP51 exhibits tissue- and cell-specific expression. (PMID: 15609043) Stenzinger A. … Wimmer M. (Histochem. Cell Biol. 2005) 3 4
  4. Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis. (PMID: 16820967) Lv B.F. … Wang L. (Apoptosis 2006) 3 4
  5. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K. … Sawa H. (J. Cell Biol. 2007) 3 4

Products for RMDN3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RMDN3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RMDN3
    • Block miRNA regulation of RMDN3 using miScript Target Protectors

    Sources for RMDN3 Gene

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