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Aliases for RMDN3 Gene

Aliases for RMDN3 Gene

  • Regulator Of Microtubule Dynamics 3 2 3
  • Ptpip51 3 4 6
  • FAM82A2 3 4 6
  • FAM82C 3 4 6
  • Protein Tyrosine Phosphatase-Interacting Protein 51 3 4
  • Family With Sequence Similarity 82, Member A2 2 3
  • TCPTP-Interacting Protein 51 3 4
  • Cerebral Protein 10 3 4
  • RMD-3 3 4
  • RMD3 3 6
  • Family With Sequence Similarity 82, Member C 3
  • Regulator Of Microtubule Dynamics Protein 3 3
  • Microtubule-Associated Protein 3
  • Protein FAM82A2 4
  • Protein FAM82C 4
  • HRMD-3 4

External Ids for RMDN3 Gene

Previous HGNC Symbols for RMDN3 Gene

  • FAM82C
  • FAM82A2

Previous GeneCards Identifiers for RMDN3 Gene

  • GC15M041029

Summaries for RMDN3 Gene

GeneCards Summary for RMDN3 Gene

RMDN3 (Regulator Of Microtubule Dynamics 3) is a Protein Coding gene. An important paralog of this gene is RMDN2.

UniProtKB/Swiss-Prot for RMDN3 Gene

  • Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN3 Gene

Genomics for RMDN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RMDN3 Gene

40,735,884 bp from pter
40,755,851 bp from pter
19,968 bases
Minus strand

Genomic View for RMDN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RMDN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN3 Gene

No data available for Regulatory Elements for RMDN3 Gene

Proteins for RMDN3 Gene

  • Protein details for RMDN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of microtubule dynamics protein 3
    Protein Accession:
    Secondary Accessions:
    • A9UMZ9
    • B3KRR3
    • Q6ZWE9
    • Q96H23
    • Q96SD6
    • Q9H6G1
    • Q9NVQ6

    Protein attributes for RMDN3 Gene

    470 amino acids
    Molecular mass:
    52118 Da
    Quaternary structure:
    • Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.
    • Sequence=BAB15298.1; Type=Erroneous termination; Positions=453; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC85554.1; Type=Frameshift; Positions=383; Evidence={ECO:0000305};

    Alternative splice isoforms for RMDN3 Gene


neXtProt entry for RMDN3 Gene

Proteomics data for RMDN3 Gene at MOPED

Post-translational modifications for RMDN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RMDN3 Gene

No data available for DME Specific Peptides for RMDN3 Gene

Domains for RMDN3 Gene

Protein Domains for RMDN3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q96TC7
  • The transmembrane region is required for mitochondrial localization
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RMDN3 Gene

Function for RMDN3 Gene

Molecular function for RMDN3 Gene

UniProtKB/Swiss-Prot Function: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
UniProtKB/Swiss-Prot Induction: By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D(3).

Gene Ontology (GO) - Molecular Function for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18771726
genes like me logo Genes that share ontologies with RMDN3: view

Phenotypes for RMDN3 Gene

MGI mutant phenotypes for RMDN3:
inferred from 1 alleles
GenomeRNAi human phenotypes for RMDN3:
genes like me logo Genes that share phenotypes with RMDN3: view

Animal Model Products

CRISPR Products

miRNA for RMDN3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RMDN3 Gene

Localization for RMDN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN3 Gene

Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Gene Ontology (GO) - Cellular Components for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IDA 22131369
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with RMDN3: view

No data available for Subcellular locations from COMPARTMENTS for RMDN3 Gene

Pathways for RMDN3 Gene

SuperPathways for RMDN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IMP 22131369
GO:0006915 apoptotic process IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RMDN3: view

No data available for Pathways by source for RMDN3 Gene

Transcripts for RMDN3 Gene

Unigene Clusters for RMDN3 Gene

Regulator of microtubule dynamics 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RMDN3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP7: -
SP8: - - - -
SP9: - - - - - -
SP10: - -

ExUns: 15 ^ 16

Relevant External Links for RMDN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMDN3 Gene

mRNA expression in normal human tissues for RMDN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMDN3 Gene

SOURCE GeneReport for Unigene cluster for RMDN3 Gene Hs.511067

mRNA Expression by UniProt/SwissProt for RMDN3 Gene

Tissue specificity: Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
genes like me logo Genes that share expressions with RMDN3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RMDN3 Gene

Orthologs for RMDN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM82A2 35
  • 99.86 (n)
  • 100 (a)
FAM82A2 36
  • 100 (a)
(Bos Taurus)
Mammalia RMDN3 35
  • 87.79 (n)
  • 86.51 (a)
RMDN3 36
  • 86 (a)
(Canis familiaris)
Mammalia FAM82A2 35
  • 89.72 (n)
  • 88.72 (a)
RMDN3 36
  • 89 (a)
(Mus musculus)
Mammalia Rmdn3 35
  • 84.76 (n)
  • 85.04 (a)
Rmdn3 16
Rmdn3 36
  • 85 (a)
(Monodelphis domestica)
Mammalia RMDN3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RMDN3 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Rmdn3 35
  • 85.54 (n)
  • 86.75 (a)
(Gallus gallus)
Aves FAM82A2 35
  • 66.3 (n)
  • 63.36 (a)
RMDN3 36
  • 59 (a)
(Anolis carolinensis)
Reptilia RMDN3 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn3 35
  • 59.55 (n)
  • 56.59 (a)
(Danio rerio)
Actinopterygii rmdn3 35
  • 53.32 (n)
  • 46.22 (a)
rmdn3 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea C16C8.18 36
  • 21 (a)
rmd-1 36
  • 23 (a)
rmd-2 36
  • 22 (a)
rmd-3 36
  • 26 (a)
rmd-4 36
  • 27 (a)
rmd-5 36
  • 21 (a)
rmd-6 36
  • 27 (a)
sup-35 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for RMDN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN3 Gene

Gene Tree for RMDN3 (if available)
Gene Tree for RMDN3 (if available)

Paralogs for RMDN3 Gene

Paralogs for RMDN3 Gene

Selected SIMAP similar genes for RMDN3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RMDN3: view

Variants for RMDN3 Gene

Sequence variations from dbSNP and Humsavar for RMDN3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs752012 -- 40,752,692(+) AGTTA(C/T)TAAGA intron-variant
rs1043986 -- 40,736,507(-) TGCCA(C/T)TATTT utr-variant-3-prime
rs1128704 -- 40,742,283(-) TGCCT(A/G)TAATC intron-variant
rs1128707 -- 40,742,235(-) agccc(A/G)ggagt intron-variant
rs1128708 -- 40,742,221(-) agact(A/G)gcctg intron-variant

Relevant External Links for RMDN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RMDN3 Gene

Disorders for RMDN3 Gene

No disorders were found for RMDN3 Gene.

No data available for UniProtKB/Swiss-Prot for RMDN3 Gene

Publications for RMDN3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The novel protein PTPIP51 exhibits tissue- and cell-specific expression. (PMID: 15609043) Stenzinger A. … Wimmer M. (Histochem. Cell Biol. 2005) 3 4
  4. Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis. (PMID: 16820967) Lv B.F. … Wang L. (Apoptosis 2006) 3 4
  5. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K. … Sawa H. (J. Cell Biol. 2007) 3 4

Products for RMDN3 Gene

Sources for RMDN3 Gene

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