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Aliases for RMDN3 Gene

Aliases for RMDN3 Gene

  • Regulator Of Microtubule Dynamics 3 2 3 5
  • Protein Tyrosine Phosphatase-Interacting Protein 51 3 4
  • Family With Sequence Similarity 82, Member A2 2 3
  • TCPTP-Interacting Protein 51 3 4
  • Cerebral Protein 10 3 4
  • Ptpip51 3 4
  • FAM82A2 3 4
  • FAM82C 3 4
  • RMD-3 3 4
  • Family With Sequence Similarity 82, Member C 3
  • Microtubule-Associated Protein 3
  • Protein FAM82A2 4
  • Protein FAM82C 4
  • HRMD-3 4
  • RMD3 3

External Ids for RMDN3 Gene

Previous HGNC Symbols for RMDN3 Gene

  • FAM82C
  • FAM82A2

Previous GeneCards Identifiers for RMDN3 Gene

  • GC15M041029

Summaries for RMDN3 Gene

GeneCards Summary for RMDN3 Gene

RMDN3 (Regulator Of Microtubule Dynamics 3) is a Protein Coding gene. An important paralog of this gene is RMDN2.

UniProtKB/Swiss-Prot for RMDN3 Gene

  • Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN3 Gene

Genomics for RMDN3 Gene

Regulatory Elements for RMDN3 Gene

Enhancers for RMDN3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RMDN3 on UCSC Golden Path with GeneCards custom track

Promoters for RMDN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RMDN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RMDN3 Gene

40,735,884 bp from pter
40,755,851 bp from pter
19,968 bases
Minus strand

Genomic View for RMDN3 Gene

Genes around RMDN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMDN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMDN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN3 Gene

Proteins for RMDN3 Gene

  • Protein details for RMDN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of microtubule dynamics protein 3
    Protein Accession:
    Secondary Accessions:
    • A9UMZ9
    • B3KRR3
    • Q6ZWE9
    • Q96H23
    • Q96SD6
    • Q9H6G1
    • Q9NVQ6

    Protein attributes for RMDN3 Gene

    470 amino acids
    Molecular mass:
    52118 Da
    Quaternary structure:
    • Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.
    • Sequence=BAB15298.1; Type=Erroneous termination; Positions=453; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC85554.1; Type=Frameshift; Positions=383; Evidence={ECO:0000305};

    Alternative splice isoforms for RMDN3 Gene


neXtProt entry for RMDN3 Gene

Proteomics data for RMDN3 Gene at MOPED

Post-translational modifications for RMDN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMDN3 Gene

Domains & Families for RMDN3 Gene

Protein Domains for RMDN3 Gene


Suggested Antigen Peptide Sequences for RMDN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The transmembrane region is required for mitochondrial localization.
  • Belongs to the RMDN family.
  • The transmembrane region is required for mitochondrial localization.
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN3: view

No data available for Gene Families for RMDN3 Gene

Function for RMDN3 Gene

Molecular function for RMDN3 Gene

UniProtKB/Swiss-Prot Function:
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
UniProtKB/Swiss-Prot Induction:
By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D(3).

Phenotypes for RMDN3 Gene

genes like me logo Genes that share phenotypes with RMDN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RMDN3

miRNA for RMDN3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMDN3 Gene

Localization for RMDN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN3 Gene

Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Gene Ontology (GO) - Cellular Components for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005741 mitochondrial outer membrane IDA 22131369
genes like me logo Genes that share ontologies with RMDN3: view

No data available for Subcellular locations from COMPARTMENTS for RMDN3 Gene

Pathways & Interactions for RMDN3 Gene

SuperPathways for RMDN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN3 Gene


No data available for Pathways by source and SIGNOR curated interactions for RMDN3 Gene

Drugs & Compounds for RMDN3 Gene

No Compound Related Data Available

Transcripts for RMDN3 Gene

Unigene Clusters for RMDN3 Gene

Regulator of microtubule dynamics 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP7: -
SP8: - - - -
SP9: - - - - - -
SP10: - -

ExUns: 15 ^ 16

Relevant External Links for RMDN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMDN3 Gene

mRNA expression in normal human tissues for RMDN3 Gene

Protein differential expression in normal tissues from HIPED for RMDN3 Gene

This gene is overexpressed in Nasal epithelium (38.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMDN3 Gene

SOURCE GeneReport for Unigene cluster for RMDN3 Gene Hs.511067

mRNA Expression by UniProt/SwissProt for RMDN3 Gene

Tissue specificity: Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.
genes like me logo Genes that share expression patterns with RMDN3: view

Protein tissue co-expression partners for RMDN3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RMDN3 Gene

Orthologs for RMDN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RMDN3 35
  • 87.79 (n)
  • 86.51 (a)
RMDN3 36
  • 86 (a)
(Canis familiaris)
Mammalia FAM82A2 35
  • 89.72 (n)
  • 88.72 (a)
RMDN3 36
  • 89 (a)
(Mus musculus)
Mammalia Rmdn3 35
  • 84.76 (n)
  • 85.04 (a)
Rmdn3 16
Rmdn3 36
  • 85 (a)
(Pan troglodytes)
Mammalia FAM82A2 35
  • 99.86 (n)
  • 100 (a)
FAM82A2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rmdn3 35
  • 85.54 (n)
  • 86.75 (a)
(Monodelphis domestica)
Mammalia RMDN3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RMDN3 36
  • 64 (a)
(Gallus gallus)
Aves FAM82A2 35
  • 66.3 (n)
  • 63.36 (a)
RMDN3 36
  • 59 (a)
(Anolis carolinensis)
Reptilia RMDN3 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn3 35
  • 59.55 (n)
  • 56.59 (a)
(Danio rerio)
Actinopterygii rmdn3 35
  • 53.32 (n)
  • 46.22 (a)
rmdn3 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea C16C8.18 36
  • 21 (a)
rmd-1 36
  • 23 (a)
rmd-2 36
  • 22 (a)
rmd-3 36
  • 26 (a)
rmd-4 36
  • 27 (a)
rmd-5 36
  • 21 (a)
rmd-6 36
  • 27 (a)
sup-35 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
Species with no ortholog for RMDN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN3 Gene

Gene Tree for RMDN3 (if available)
Gene Tree for RMDN3 (if available)

Paralogs for RMDN3 Gene

Paralogs for RMDN3 Gene

(2) SIMAP similar genes for RMDN3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RMDN3: view

Variants for RMDN3 Gene

Sequence variations from dbSNP and Humsavar for RMDN3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs11558807 - 40,754,685(-) AGCCA(G/T)CGATG reference, missense
rs11856571 -- 40,736,494(+) GCCCC(A/C/G)CCACC utr-variant-3-prime
rs752012 -- 40,752,692(+) AGTTA(C/T)TAAGA intron-variant
rs12372947 -- 40,745,884(+) AAACT(C/G)GCAAC intron-variant
rs12438182 -- 40,750,462(+) TGATC(A/C)GCCCA intron-variant, upstream-variant-2KB

Variation tolerance for RMDN3 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RMDN3 Gene

Disorders for RMDN3 Gene

Relevant External Links for RMDN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RMDN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMDN3 Gene

Publications for RMDN3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The known interactome of PTPIP51 in HaCaT cellsa89inhibition of kinases and receptors. (PMID: 24501773) Brobeil A. … Wimmer M. (Int. J. Biochem. Cell Biol. 2014) 3

Products for RMDN3 Gene

Sources for RMDN3 Gene