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RMDN3 Gene

protein-coding   GIFtS: 43
GCID: GC15M041029

Regulator Of Microtubule Dynamics 3

(Previous names: family with sequence similarity 82, member A2)
(Previous symbols: FAM82C, FAM82A2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Regulator Of Microtubule Dynamics 31 2     PTPIP513 5
FAM82A21 2 3 5     Family With Sequence Similarity 82, Member C2
FAM82C1 2 3 5     Microtubule-Associated Protein2
Family With Sequence Similarity 82, Member A21 2     ptpip512
Cerebral Protein 102 3     Regulator Of Microtubule Dynamics Protein 32
Protein Tyrosine Phosphatase-Interacting Protein 512 3     hRMD-33
RMD-32 3     Protein FAM82A23
TCPTP-Interacting Protein 512 3     Protein FAM82C3
RMD32 5     

External Ids:    HGNC: 255501   Entrez Gene: 551772   Ensembl: ENSG000001378247   OMIM: 6118735   UniProtKB: Q96TC73   

Export aliases for RMDN3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RMDN3 Gene:
RMDN3 (regulator of microtubule dynamics 3) is a protein-coding gene. Diseases associated with RMDN3 include cerebritis, and noma. An important paralog of this gene is RMDN1.

UniProtKB/Swiss-Prot: RMD3_HUMAN, Q96TC7
Function: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of
keratinocytes. Overexpression induces apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RMDN3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRMDN3 promoter sequence
   Search Chromatin IP Primers for RMDN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RMDN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1

RMDN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RMDN3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M041029:  view genomic region     (about GC identifiers)

Start:
41,028,082 bp from pter      End:
41,048,049 bp from pter
Size:
19,968 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RMD3_HUMAN, Q96TC7 (See protein sequence)
Recommended Name: Regulator of microtubule dynamics protein 3  
Size: 470 amino acids; 52118 Da
Subunit: Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB
Sequence caution: Sequence=BAB15298.1; Type=Erroneous termination; Positions=453; Note=Translated as Glu;
Sequence=BAC85554.1; Type=Frameshift; Positions=383;
Secondary accessions: A9UMZ9 B3KRR3 Q6ZWE9 Q96H23 Q96SD6 Q9H6G1 Q9NVQ6
Alternative splicing: 2 isoforms:  Q96TC7-1   Q96TC7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RMDN3: NX_Q96TC7

Explore proteomics data for RMDN3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RMDN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060615.1  
    ENSEMBL proteins: 
     ENSP00000260385   ENSP00000453357   ENSP00000342493   ENSP00000453535   ENSP00000453978  
     ENSP00000453199  

    RMDN3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry Q96TC7

    ProtoNet protein and cluster: Q96TC7

    UniProtKB/Swiss-Prot: RMD3_HUMAN, Q96TC7
    Domain: The transmembrane region is required for mitochondrial localization
    Similarity: Belongs to the RMDN family


    RMDN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RMD3_HUMAN, Q96TC7
    Function: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of
    keratinocytes. Overexpression induces apoptosis
    Induction: By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D(3)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18771726
         
    RMDN3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RMDN3:
     Increased S DNA content  Increased number of mitotic ce 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rmdn3):
     normal 

    RMDN3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RMDN3
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    miRTarBase miRNAs that target RMDN3:
    hsa-mir-93-5p (MIRT028031), hsa-mir-375 (MIRT019889), hsa-mir-193b-3p (MIRT041538), hsa-mir-505-5p (MIRT037970)

    Block miRNA regulation of human, mouse, rat RMDN3 using miScript Target Protectors
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RMDN3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RMD3_HUMAN, Q96TC7: Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane.
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase
    localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IEA--
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane IDA--
    GO:0005874microtubule IEA--

    RMDN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RMDN3
    Interactions:

        Search GeneGlobe Interaction Network for RMDN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for RMDN3 (Q96TC71, 2, 3 ENSP000002603854) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619811, 2, 3, ENSP000003063304EBI-1056589,EBI-359832 MINT-8008619 MINT-50836 I2D: score=5 STRING: ENSP00000306330
    YWHABP319462, 3, ENSP000003001614MINT-50964 MINT-8008612 I2D: score=4 STRING: ENSP00000300161
    VAPAQ9P0L02, 3, ENSP000003456564MINT-8276938 I2D: score=2 STRING: ENSP00000345656
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006874cellular calcium ion homeostasis IMP--
    GO:0006915apoptotic process IEA--
    GO:0030154cell differentiation IEA--

    RMDN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RMDN3 (RMD3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RMDN3 gene: 
    NM_018145.1  

    Unigene Cluster for RMDN3:

    Regulator of microtubule dynamics 3
    Hs.511067  [show with all ESTs]
    Unigene Representative Sequence: AK123282
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260385(uc001zmq.1) ENST00000560588 ENST00000558777 ENST00000338376(uc001zmo.1 uc001zmp.1)
    ENST00000557831 ENST00000558232 ENST00000560779 ENST00000558560 ENST00000560460
    ENST00000558364 ENST00000560905
    miRNA
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    OriGene qPCR primer pairs and template standards for RMDN3
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    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat RMDN3
      QuantiTect SYBR Green Assays in human, mouse, rat RMDN3
      QuantiFast Probe-based Assays in human, mouse, rat RMDN3

    Additional mRNA sequence: 

    AB000782.1 AK001441.1 AK025963.1 AK090731.1 AK092058.1 AK097286.1 AK123192.1 AK123282.1 
    AY358793.1 BC008970.2 BC063844.1 

    17 DOTS entries:

    DT.97844993  DT.95304189  DT.100726461  DT.100029930  DT.448328  DT.100826583  DT.101984540  DT.100712726 
    DT.101984538  DT.95304202  DT.121048639  DT.102831094  DT.121048657  DT.121048704  DT.121048705  DT.92003623 
    DT.99936772 

    Selected AceView cDNA sequences (see all 317):

    BG396785 AA724122 BE019801 BQ225450 BP373202 CD742933 CD723874 BC008970 
    CA431917 BP359229 BU177846 BI820234 BQ668753 CB851715 BE207348 AI033238 
    AK092058 BM754475 CA308615 AL559886 BE272028 BM904832 BU170881 BU542059 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RMDN3 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
    SP1:                                                        -                 -                       -     -                       -                           
    SP2:                                                        -                 -                       -     -                       -                           
    SP3:                    -                                   -                 -                       -     -                       -                           
    SP4:                                                        -                 -                       -     -                       -                           
    SP5:                                                                                                  -                             -                           

    ExUns: 15 ^ 16
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for RMDN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RMDN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RMDN3 Expression
    About this image


    RMDN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RMDN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RMDN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511067

    UniProtKB/Swiss-Prot: RMD3_HUMAN, Q96TC7
    Tissue specificity: Present at high level in epidermis and seminiferous epithelium: while basal cells in the
    epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating
    first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is
    restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated
    with the microtubular structures responsible for ciliary movement. Also present in specific structures of the
    central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system,
    and axons of the peripheral nervous system (at protein level). Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RMDN3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RMDN3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rmdn31 , 5 family with sequence similarity 82, member A25
    regulator of microtubule dynamics 31
    84.76(n)1
    85.04(a)1
      2 (59.94 cM)5
    678091  NM_001033136.31  NP_001028308.11 
     1191370015 
    chicken
    (Gallus gallus)
    Aves FAM82A21 family with sequence similarity 82, member A2 66.3(n)
    63.36(a)
      423004  XM_420936.4  XP_420936.3 
    lizard
    (Anolis carolinensis)
    Reptilia RMDN36
    regulator of microtubule dynamics 3
    60(a)
    1 ↔ 1
    GL343264.1(538443-571930)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rmdn31 regulator of microtubule dynamics 3 59.55(n)
    56.59(a)
      100170170  NM_001129926.1  NP_001123398.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rmdn31 regulator of microtubule dynamics 3 53.32(n)
    46.22(a)
      100034410  NM_001083050.1  NP_001076519.1 
    worm
    (Caenorhabditis elegans)
    Secernentea rmd-46
    rmd-66
    (see all 8)
    Protein RMD-6 (rmd-6) mRNA, complete cds
    (see all 8)
    27(a)
    27(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    IV(5255912-5256792) WBGene00018125
    IV(5068868-5069853) WBGene00020070


    ENSEMBL Gene Tree for RMDN3 (if available)
    TreeFam Gene Tree for RMDN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RMDN3 gene
    RMDN12  RMDN22  
    2 SIMAP similar genes for RMDN3 using alignment to 5 protein entries:     RMD3_HUMAN (see all proteins):
    RMDN2    RMDN1

    RMDN3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RMDN3 (see all 495)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118556261,2
    H--41027661(+) agtagA/Ctgaga 1 -- ds50010--------
    rs49245021,2
    C,F,A,H--41027789(+) CGCCTC/TGGCCT 1 -- ds500110Minor allele frequency- T:0.27WA NA CSA EA 258
    rs1874581801,2
    --41027833(+) AGCTAC/GCACGC 1 -- ds50010--------
    rs800317591,2
    C--41027846(+) GGCCTA/GTGCAT 1 -- ds50012Minor allele frequency- G:0.17WA 120
    rs1448609571,2
    C--41027902(+) GTGGCC/TCTAAA 1 -- ds50010--------
    rs1485545771,2
    --41027910(+) AAAAAC/TGAACA 1 -- ds50010--------
    rs1931396111,2
    --41027928(+) GGCAGG/TGAGTA 1 -- ds50010--------
    rs1840263131,2
    --41027946(+) AGTTGC/TAATAG 1 -- ds50010--------
    rs1429420521,2
    C--41028226(+) GTGGTC/TCAGCC 1 -- ut310--------
    rs1174451971,2
    C,F--41028342(+) ATATGT/CACTGA 1 -- ut311Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for RMDN3 (41028082 - 41048049 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RMDN3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RMDN3
    DNA2.0 Custom Variant and Variant Library Synthesis for RMDN3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611873    OMIM disorders: --

    11 diseases for RMDN3:    
    About MalaCards
    cerebritis    noma    acute myeloid leukemia    tonsillitis
    myeloid leukemia    alzheimer's disease    leukemia    thyroiditis
    prostatitis    neuronitis    endotheliitis


    RMDN3 for disorders           About GeneDecksing


    Export disorders for RMDN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RMDN3 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with RMDN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PubMed id 18070910)1, 2 Oishi K.... Sawa H. (J. Cell Biol. 2007)
    3. Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis. (PubMed id 16820967)1, 2 Lv B.F.... Wang L. (Apoptosis 2006)
    4. The novel protein PTPIP51 exhibits tissue- and cell-specific expression. (PubMed id 15609043)1, 2 Stenzinger A.... Wimmer M. (Histochem. Cell Biol. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. PTPIP51 in protein interactions: regulation and in situ interacting partners. (PubMed id 22544307)1 Brobeil A....Wimmer M. (Cell Biochem. Biophys. 2012)
    10. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. (PubMed id 22131369)2 De Vos K.J.... Miller C.C. (Hum. Mol. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55177 HGNC: 25550 AceView: FLJ10579 Ensembl:ENSG00000137824 euGenes: HUgn55177
    ECgene: RMDN3 H-InvDB: RMDN3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RMDN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RMDN3 gene:
    Search GeneIP for patents involving RMDN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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