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Aliases for RMDN2 Gene

Aliases for RMDN2 Gene

  • Regulator Of Microtubule Dynamics 2 2 3
  • FAM82A1 3 4 6
  • FAM82A 3 4 6
  • Family With Sequence Similarity 82, Member A1 2 3
  • RMD-2 3 4
  • RMD2 3 6
  • Family With Sequence Similarity 82, Member A 3
  • Regulator Of Microtubule Dynamics Protein 2 3
  • Microtubule-Associated Protein 3
  • Protein FAM82A1 4
  • PRO34163 3
  • PYST9371 3
  • BLOCK18 3
  • HRMD-2 4
  • RMD4 3

External Ids for RMDN2 Gene

Previous HGNC Symbols for RMDN2 Gene

  • FAM82A
  • FAM82A1

Previous GeneCards Identifiers for RMDN2 Gene

  • GC02P038151

Summaries for RMDN2 Gene

GeneCards Summary for RMDN2 Gene

RMDN2 (Regulator Of Microtubule Dynamics 2) is a Protein Coding gene. An important paralog of this gene is RMDN3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN2 Gene

Genomics for RMDN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RMDN2 Gene

37,923,187 bp from pter
38,067,142 bp from pter
143,956 bases
Plus strand

Genomic View for RMDN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RMDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN2 Gene

No data available for Regulatory Elements for RMDN2 Gene

Proteins for RMDN2 Gene

  • Protein details for RMDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of microtubule dynamics protein 2
    Protein Accession:
    Secondary Accessions:
    • A9UMZ7
    • A9UN00
    • Q4ZG33
    • Q6UXN4
    • Q8N657
    • Q8N9A2
    • Q8NCV6
    • Q8NHM0

    Protein attributes for RMDN2 Gene

    410 amino acids
    Molecular mass:
    47399 Da
    Quaternary structure:
    • Interacts with microtubules.
    • Sequence=AAM81211.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RMDN2 Gene


neXtProt entry for RMDN2 Gene

Proteomics data for RMDN2 Gene at MOPED

Post-translational modifications for RMDN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMDN2 Gene

Domains for RMDN2 Gene

Protein Domains for RMDN2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RMDN family.
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for RMDN2 Gene

Function for RMDN2 Gene

Gene Ontology (GO) - Molecular Function for RMDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RMDN2: view
genes like me logo Genes that share phenotypes with RMDN2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RMDN2 Gene

Localization for RMDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN2 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region.

Gene Ontology (GO) - Cellular Components for RMDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005874 microtubule IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RMDN2: view

No data available for Subcellular locations from COMPARTMENTS for RMDN2 Gene

Pathways for RMDN2 Gene

SuperPathways for RMDN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN2 Gene


No data available for Pathways by source for RMDN2 Gene

Transcripts for RMDN2 Gene

Unigene Clusters for RMDN2 Gene

Regulator of microtubule dynamics 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RMDN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - - -

Relevant External Links for RMDN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMDN2 Gene

mRNA expression in normal human tissues for RMDN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RMDN2 Gene

This gene is overexpressed in Adrenal Gland (6.6).

Protein differential expression in normal tissues for RMDN2 Gene

This gene is overexpressed in Bone (19.4), Adrenal (15.0), and Liver (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMDN2 Gene

SOURCE GeneReport for Unigene cluster for RMDN2 Gene Hs.591566

genes like me logo Genes that share expressions with RMDN2: view

Expression partners for RMDN2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RMDN2 Gene

Orthologs for RMDN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM82A1 35
  • 89.19 (n)
  • 83.9 (a)
RMDN2 36
  • 54 (a)
(Mus musculus)
Mammalia Rmdn2 35
  • 81.46 (n)
  • 79.51 (a)
Rmdn2 16
Rmdn2 36
  • 54 (a)
(Pan troglodytes)
Mammalia FAM82A1 35
  • 99.43 (n)
  • 99.51 (a)
RMDN2 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Rmdn2 35
  • 81.63 (n)
  • 78.78 (a)
(Bos Taurus)
Mammalia RMDN2 36
  • 47 (a)
(Monodelphis domestica)
Mammalia RMDN2 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia RMDN2 36
  • 37 (a)
(Gallus gallus)
Aves FAM82A1 35
  • 64.79 (n)
  • 54.03 (a)
RMDN2 36
  • 35 (a)
(Anolis carolinensis)
Reptilia RMDN2 36
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn2 35
  • 60.95 (n)
  • 50.75 (a)
(Danio rerio)
Actinopterygii RMDN2 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea C16C8.18 36
  • 22 (a)
rmd-1 36
  • 24 (a)
rmd-2 36
  • 19 (a)
rmd-3 36
  • 25 (a)
rmd-4 36
  • 25 (a)
rmd-5 36
  • 21 (a)
rmd-6 36
  • 26 (a)
sup-35 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for RMDN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN2 Gene

Gene Tree for RMDN2 (if available)
Gene Tree for RMDN2 (if available)

Paralogs for RMDN2 Gene

Paralogs for RMDN2 Gene

(2) SIMAP similar genes for RMDN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RMDN2: view

Variants for RMDN2 Gene

Sequence variations from dbSNP and Humsavar for RMDN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs100461 -- 38,038,835(+) ATCAC(C/T)GGGTC intron-variant
rs100489 -- 38,039,335(-) GATCT(A/G)TGGGC intron-variant
rs151253 -- 38,066,927(+) CCAAA(A/G)TTTCA intron-variant
rs163076 -- 38,055,592(+) agtca(A/T)ttttg intron-variant
rs163077 -- 38,058,462(-) AGCTG(A/G)TGAGG intron-variant

Relevant External Links for RMDN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RMDN2 Gene

Disorders for RMDN2 Gene

No disorders were found for RMDN2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for RMDN2 Gene

Publications for RMDN2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K. … Sawa H. (J. Cell Biol. 2007) 3 4
  5. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3

Products for RMDN2 Gene

Sources for RMDN2 Gene

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