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Aliases for RMDN2 Gene

Aliases for RMDN2 Gene

  • Regulator Of Microtubule Dynamics 2 2 3 5
  • Family With Sequence Similarity 82, Member A1 2 3
  • FAM82A1 3 4
  • FAM82A 3 4
  • RMD-2 3 4
  • Family With Sequence Similarity 82, Member A 3
  • Microtubule-Associated Protein 3
  • Protein FAM82A1 4
  • PRO34163 3
  • PYST9371 3
  • BLOCK18 3
  • HRMD-2 4
  • RMD2 3
  • RMD4 3

External Ids for RMDN2 Gene

Previous HGNC Symbols for RMDN2 Gene

  • FAM82A
  • FAM82A1

Previous GeneCards Identifiers for RMDN2 Gene

  • GC02P038151

Summaries for RMDN2 Gene

GeneCards Summary for RMDN2 Gene

RMDN2 (Regulator Of Microtubule Dynamics 2) is a Protein Coding gene. An important paralog of this gene is RMDN3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN2 Gene

Genomics for RMDN2 Gene

Regulatory Elements for RMDN2 Gene

Enhancers for RMDN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RMDN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RMDN2 Gene

37,920,845 bp from pter
38,069,970 bp from pter
149,126 bases
Plus strand

Genomic View for RMDN2 Gene

Genes around RMDN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMDN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN2 Gene

Proteins for RMDN2 Gene

  • Protein details for RMDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of microtubule dynamics protein 2
    Protein Accession:
    Secondary Accessions:
    • A9UMZ7
    • A9UN00
    • Q4ZG33
    • Q6UXN4
    • Q8N657
    • Q8N9A2
    • Q8NCV6
    • Q8NHM0

    Protein attributes for RMDN2 Gene

    410 amino acids
    Molecular mass:
    47399 Da
    Quaternary structure:
    • Interacts with microtubules.
    • Sequence=AAM81211.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RMDN2 Gene


neXtProt entry for RMDN2 Gene

Proteomics data for RMDN2 Gene at MOPED

Post-translational modifications for RMDN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMDN2 Gene

Domains & Families for RMDN2 Gene

Protein Domains for RMDN2 Gene


Suggested Antigen Peptide Sequences for RMDN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RMDN family.
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN2: view

No data available for Gene Families for RMDN2 Gene

Function for RMDN2 Gene

genes like me logo Genes that share phenotypes with RMDN2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RMDN2 Gene

Localization for RMDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN2 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region.

Gene Ontology (GO) - Cellular Components for RMDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RMDN2: view

No data available for Subcellular locations from COMPARTMENTS for RMDN2 Gene

Pathways & Interactions for RMDN2 Gene

SuperPathways for RMDN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RMDN2 Gene

Drugs & Compounds for RMDN2 Gene

No Compound Related Data Available

Transcripts for RMDN2 Gene

Unigene Clusters for RMDN2 Gene

Regulator of microtubule dynamics 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - - -

Relevant External Links for RMDN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMDN2 Gene

mRNA expression in normal human tissues for RMDN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RMDN2 Gene

This gene is overexpressed in Adrenal Gland (x6.6).

Protein differential expression in normal tissues from HIPED for RMDN2 Gene

This gene is overexpressed in Bone (19.4), Adrenal (15.0), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RMDN2 Gene

SOURCE GeneReport for Unigene cluster for RMDN2 Gene Hs.591566

genes like me logo Genes that share expression patterns with RMDN2: view

Protein tissue co-expression partners for RMDN2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RMDN2 Gene

Orthologs for RMDN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia FAM82A1 35
  • 89.19 (n)
  • 83.9 (a)
RMDN2 36
  • 54 (a)
(Mus musculus)
Mammalia Rmdn2 35
  • 81.46 (n)
  • 79.51 (a)
Rmdn2 16
Rmdn2 36
  • 54 (a)
(Pan troglodytes)
Mammalia FAM82A1 35
  • 99.43 (n)
  • 99.51 (a)
RMDN2 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Rmdn2 35
  • 81.63 (n)
  • 78.78 (a)
(Bos Taurus)
Mammalia RMDN2 36
  • 47 (a)
(Monodelphis domestica)
Mammalia RMDN2 36
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia RMDN2 36
  • 37 (a)
(Gallus gallus)
Aves FAM82A1 35
  • 64.79 (n)
  • 54.03 (a)
RMDN2 36
  • 35 (a)
(Anolis carolinensis)
Reptilia RMDN2 36
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn2 35
  • 60.95 (n)
  • 50.75 (a)
(Danio rerio)
Actinopterygii RMDN2 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea C16C8.18 36
  • 22 (a)
rmd-1 36
  • 24 (a)
rmd-2 36
  • 19 (a)
rmd-3 36
  • 25 (a)
rmd-4 36
  • 25 (a)
rmd-5 36
  • 21 (a)
rmd-6 36
  • 26 (a)
sup-35 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for RMDN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN2 Gene

Gene Tree for RMDN2 (if available)
Gene Tree for RMDN2 (if available)

Paralogs for RMDN2 Gene

Paralogs for RMDN2 Gene

(2) SIMAP similar genes for RMDN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RMDN2: view

Variants for RMDN2 Gene

Sequence variations from dbSNP and Humsavar for RMDN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_032316 -
rs1583171 -- 38,042,964(-) gaata(C/T)acatt intron-variant
rs1867771 -- 37,923,209(-) AACCA(C/T)TGACC intron-variant
rs964806 -- 37,921,874(-) ATATG(A/C)ATTAT intron-variant
rs964807 -- 37,921,617(-) ATGTG(A/T)TATTA intron-variant

Variation tolerance for RMDN2 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for RMDN2 Gene

Disorders for RMDN2 Gene

Relevant External Links for RMDN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RMDN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMDN2 Gene

Publications for RMDN2 Gene

  1. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K. … Sawa H. (J. Cell Biol. 2007) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RMDN2 Gene

Sources for RMDN2 Gene