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Aliases for RMDN2 Gene

Aliases for RMDN2 Gene

  • Regulator Of Microtubule Dynamics 2 2 3 5
  • Family With Sequence Similarity 82, Member A1 2 3
  • FAM82A1 3 4
  • FAM82A 3 4
  • RMD-2 3 4
  • Family With Sequence Similarity 82, Member A 3
  • Regulator Of Microtubule Dynamics Protein 2 3
  • Microtubule-Associated Protein 3
  • Protein FAM82A1 4
  • PRO34163 3
  • PYST9371 3
  • BLOCK18 3
  • HRMD-2 4
  • RMD2 3
  • RMD4 3

External Ids for RMDN2 Gene

Previous HGNC Symbols for RMDN2 Gene

  • FAM82A
  • FAM82A1

Previous GeneCards Identifiers for RMDN2 Gene

  • GC02P038151

Summaries for RMDN2 Gene

GeneCards Summary for RMDN2 Gene

RMDN2 (Regulator Of Microtubule Dynamics 2) is a Protein Coding gene. An important paralog of this gene is RMDN3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN2 Gene

Genomics for RMDN2 Gene

Regulatory Elements for RMDN2 Gene

Enhancers for RMDN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G037388 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -530.5 -530485 3.0 PKNOX1 FOXA2 ATF1 WRNIP1 SIN3A YY1 TCF12 GATA2 ELK1 CBX5 LOC101929542 PRKD3 QPCT RNU6-939P CYP1B1 RMDN2 CDC42EP3 EIF2AK2 GC02P037427
GH02G037375 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -543.3 -543313 3.3 PKNOX1 ARNT FEZF1 ZNF2 GATA2 CBX5 ZNF207 FOS SP3 JUNB PRKD3 LOC101929542 RNU6-939P CDC42EP3 RMDN2 CYP1B1 QPCT GPATCH11 GC02P037427
GH02G037921 1.1 ENCODE 15.7 +3.2 3246 5.5 HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B RMDN2 CYP1B1 GC02P037921 GC02P037956
GH02G037892 1.3 FANTOM5 Ensembl ENCODE 13.2 -28.0 -27951 1.5 TBP PKNOX1 ZMYM3 RAD21 ARID3A POLR2A CBX5 NFYB ZNF143 RELB RMDN2 CYP1B1 LINC00211
GH02G037933 1.1 Ensembl ENCODE 15 +14.0 14037 2.4 TBL1XR1 BMI1 RAD21 CBX5 RELB ETV6 IKZF2 CREM CBFB JUNB RMDN2 GC02P037921 GC02P037956
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RMDN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RMDN2 Gene

Chromosome:
2
Start:
37,920,845 bp from pter
End:
38,069,970 bp from pter
Size:
149,126 bases
Orientation:
Plus strand

Genomic View for RMDN2 Gene

Genes around RMDN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMDN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN2 Gene

Proteins for RMDN2 Gene

  • Protein details for RMDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LZ7-RMD2_HUMAN
    Recommended name:
    Regulator of microtubule dynamics protein 2
    Protein Accession:
    Q96LZ7
    Secondary Accessions:
    • A9UMZ7
    • A9UN00
    • Q4ZG33
    • Q6UXN4
    • Q8N657
    • Q8N9A2
    • Q8NCV6
    • Q8NHM0

    Protein attributes for RMDN2 Gene

    Size:
    410 amino acids
    Molecular mass:
    47399 Da
    Quaternary structure:
    • Interacts with microtubules.
    SequenceCaution:
    • Sequence=AAM81211.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RMDN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RMDN2 Gene

Post-translational modifications for RMDN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMDN2 Gene

Domains & Families for RMDN2 Gene

Protein Domains for RMDN2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RMDN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LZ7

UniProtKB/Swiss-Prot:

RMD2_HUMAN :
  • Belongs to the RMDN family.
Family:
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN2: view

No data available for Gene Families for RMDN2 Gene

Function for RMDN2 Gene

Gene Ontology (GO) - Molecular Function for RMDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RMDN2: view
genes like me logo Genes that share phenotypes with RMDN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RMDN2 Gene

Localization for RMDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN2 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMDN2 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 1

Gene Ontology (GO) - Cellular Components for RMDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RMDN2: view

Pathways & Interactions for RMDN2 Gene

SuperPathways for RMDN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RMDN2 Gene

Drugs & Compounds for RMDN2 Gene

No Compound Related Data Available

Transcripts for RMDN2 Gene

Unigene Clusters for RMDN2 Gene

Regulator of microtubule dynamics 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - - -

Relevant External Links for RMDN2 Gene

GeneLoc Exon Structure for
RMDN2
ECgene alternative splicing isoforms for
RMDN2

Expression for RMDN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RMDN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RMDN2 Gene

This gene is overexpressed in Adrenal Gland (x6.6).

Protein differential expression in normal tissues from HIPED for RMDN2 Gene

This gene is overexpressed in Bone (19.4), Adrenal (15.0), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RMDN2 Gene



Protein tissue co-expression partners for RMDN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RMDN2 Gene:

RMDN2

SOURCE GeneReport for Unigene cluster for RMDN2 Gene:

Hs.591566

Evidence on tissue expression from TISSUES for RMDN2 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RMDN2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMDN2 Gene

Orthologs for RMDN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM82A1 34
  • 99.43 (n)
RMDN2 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM82A1 34
  • 89.19 (n)
RMDN2 35
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rmdn2 34
  • 81.63 (n)
mouse
(Mus musculus)
Mammalia Rmdn2 34 16 35
  • 81.46 (n)
cow
(Bos Taurus)
Mammalia RMDN2 35
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RMDN2 35
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RMDN2 35
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM82A1 34
  • 64.79 (n)
RMDN2 35
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RMDN2 35
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn2 34
  • 60.95 (n)
zebrafish
(Danio rerio)
Actinopterygii RMDN2 35
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rmd-6 35
  • 26 (a)
ManyToMany
rmd-3 35
  • 25 (a)
ManyToMany
rmd-4 35
  • 25 (a)
ManyToMany
rmd-1 35
  • 24 (a)
ManyToMany
C16C8.18 35
  • 22 (a)
ManyToMany
rmd-5 35
  • 21 (a)
ManyToMany
rmd-2 35
  • 19 (a)
ManyToMany
sup-35 35
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
Species where no ortholog for RMDN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN2 Gene

ENSEMBL:
Gene Tree for RMDN2 (if available)
TreeFam:
Gene Tree for RMDN2 (if available)

Paralogs for RMDN2 Gene

Paralogs for RMDN2 Gene

(2) SIMAP similar genes for RMDN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RMDN2: view

Variants for RMDN2 Gene

Sequence variations from dbSNP and Humsavar for RMDN2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs162549 Likely benign 38,068,313(-) GGCTT(A/T)TTTAA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs9309020 Likely benign 38,068,351(-) GTTTA(C/T)ATGGA downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs35320531 Uncertain significance 38,068,389(-) CAGTC(A/G)TCATC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs561615550 Uncertain significance 38,068,407(+) AAAAA(-/A)CAGAT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs886055986 Uncertain significance 38,067,644(-) ACTGG(A/G)ACACC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RMDN2 Gene

Variant ID Type Subtype PubMed ID
dgv6787n54 CNV loss 21841781
esv2659660 CNV deletion 23128226
esv2671607 CNV deletion 23128226
esv2719941 CNV deletion 23290073
esv2762251 CNV loss 21179565
esv3590412 CNV loss 21293372
nsv516007 CNV gain+loss 19592680
nsv963223 CNV duplication 23825009

Variation tolerance for RMDN2 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RMDN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RMDN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMDN2 Gene

Disorders for RMDN2 Gene

Relevant External Links for RMDN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RMDN2

No disorders were found for RMDN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMDN2 Gene

Publications for RMDN2 Gene

  1. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K. … Sawa H. (J. Cell Biol. 2007) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RMDN2 Gene

Sources for RMDN2 Gene

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