Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RMDN1 Gene

Aliases for RMDN1 Gene

  • Regulator Of Microtubule Dynamics 1 2 3 5
  • Family With Sequence Similarity 82, Member B 2 3
  • FAM82B 3 4
  • RMD-1 3 4
  • Regulator Of Microtubule Dynamics Protein 1 3
  • Microtubule-Associated Protein 3
  • Protein FAM82B 4
  • CGI-90 3
  • HRMD-1 4
  • RMD1 3

External Ids for RMDN1 Gene

Previous HGNC Symbols for RMDN1 Gene

  • FAM82B

Previous GeneCards Identifiers for RMDN1 Gene

  • GC08M087481

Summaries for RMDN1 Gene

GeneCards Summary for RMDN1 Gene

RMDN1 (Regulator Of Microtubule Dynamics 1) is a Protein Coding gene. An important paralog of this gene is RMDN3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN1 Gene

Genomics for RMDN1 Gene

Regulatory Elements for RMDN1 Gene

Enhancers for RMDN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F086341 1.1 ENCODE 24.4 +171.0 171001 4.3 ATF1 PKNOX1 ARID4B SIN3A YY1 ELK1 GATA2 SP3 SP5 NFYC RMDN1 WWP1 LOC105375624
GH08F086507 1.1 ENCODE 23.4 +6.0 6008 2.6 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ETS1 RMDN1 WWP1 NTAN1P2 LOC105375624 CPNE3 SLC2A3P4
GH08F086289 1.2 Ensembl ENCODE 19.7 +224.1 224101 1.1 ATF1 FEZF1 DMAP1 ZNF2 YY1 MIER2 KAT8 MIER3 RCOR2 ZNF792 RMDN1 WWP1 SLC7A13 LOC105375623
GH08F086522 1 Ensembl ENCODE 22.9 -8.8 -8762 1.8 PKNOX1 ESRRA ZNF316 CTBP1 FOSL2 FOS MAFK MTA2 DPF2 TBX21 RMDN1 CPNE3 MIOXP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RMDN1 on UCSC Golden Path with GeneCards custom track

Promoters for RMDN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001395684 -443 1601 ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF207 SP3 MXD4 REST KAT8

Genomic Location for RMDN1 Gene

86,467,398 bp from pter
86,514,357 bp from pter
46,960 bases
Minus strand

Genomic View for RMDN1 Gene

Genes around RMDN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMDN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN1 Gene

Proteins for RMDN1 Gene

  • Protein details for RMDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of microtubule dynamics protein 1
    Protein Accession:
    Secondary Accessions:
    • A9UMZ8
    • B4DNF5
    • B4DZW6
    • B5MC61
    • C9JSC6
    • E7EVI2
    • Q9Y398

    Protein attributes for RMDN1 Gene

    314 amino acids
    Molecular mass:
    35808 Da
    Quaternary structure:
    • Interacts with microtubules.

    Alternative splice isoforms for RMDN1 Gene


neXtProt entry for RMDN1 Gene

Post-translational modifications for RMDN1 Gene

  • Ubiquitination at Lys 230, Lys 243, and Lys 261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RMDN1 Gene

Domains & Families for RMDN1 Gene

Protein Domains for RMDN1 Gene


Suggested Antigen Peptide Sequences for RMDN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RMDN family.
  • Contains 2 TPR repeats.
  • Belongs to the RMDN family.
  • Contains 2 TPR repeats.
genes like me logo Genes that share domains with RMDN1: view

No data available for Gene Families for RMDN1 Gene

Function for RMDN1 Gene

genes like me logo Genes that share phenotypes with RMDN1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMDN1 Gene

Localization for RMDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMDN1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RMDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with RMDN1: view

Pathways & Interactions for RMDN1 Gene

SuperPathways for RMDN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RMDN1 Gene

Transcripts for RMDN1 Gene

Unigene Clusters for RMDN1 Gene

Regulator of microtubule dynamics 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN1 Gene

No ASD Table

Relevant External Links for RMDN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMDN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RMDN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RMDN1 Gene

This gene is overexpressed in Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RMDN1 Gene

Protein tissue co-expression partners for RMDN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RMDN1 Gene:


SOURCE GeneReport for Unigene cluster for RMDN1 Gene:

genes like me logo Genes that share expression patterns with RMDN1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RMDN1 Gene

Orthologs for RMDN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM82B 34
  • 99.58 (n)
RMDN1 35
  • 99 (a)
(Canis familiaris)
Mammalia FAM82B 34
  • 88.85 (n)
RMDN1 35
  • 88 (a)
(Bos Taurus)
Mammalia RMDN1 34 35
  • 86.94 (n)
(Mus musculus)
Mammalia Rmdn1 34 16 35
  • 86.34 (n)
(Rattus norvegicus)
Mammalia Rmdn1 34
  • 86.24 (n)
(Monodelphis domestica)
Mammalia RMDN1 35
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia RMDN1 35
  • 71 (a)
(Gallus gallus)
Aves FAM82B 34 35
  • 72.79 (n)
(Anolis carolinensis)
Reptilia RMDN1 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn1 34
  • 62.28 (n)
Str.15080 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64464 34
(Danio rerio)
Actinopterygii zgc:171674 34
  • 62.34 (n)
RMDN1 35
  • 52 (a)
Dr.12839 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9264 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012364 34
  • 46.19 (n)
(Caenorhabditis elegans)
Secernentea F33H2.6 34 35
  • 49.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
Species where no ortholog for RMDN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN1 Gene

Gene Tree for RMDN1 (if available)
Gene Tree for RMDN1 (if available)

Paralogs for RMDN1 Gene

Paralogs for RMDN1 Gene

genes like me logo Genes that share paralogs with RMDN1: view

Variants for RMDN1 Gene

Sequence variations from dbSNP and Humsavar for RMDN1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10089169 -- 86,491,781(+) TGACC(C/T)CCTAC intron-variant
rs10090898 -- 86,499,797(+) tacta(C/T)gagac intron-variant
rs10098365 -- 86,514,595(+) GCAAC(C/G)GTACC intron-variant, upstream-variant-2KB
rs10100254 -- 86,500,038(+) caaaa(C/T)ggatt intron-variant
rs10100368 -- 86,470,015(+) GCTAG(C/T)ACACA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RMDN1 Gene

Variant ID Type Subtype PubMed ID
nsv1023510 CNV loss 25217958
nsv971681 CNV duplication 23825009

Variation tolerance for RMDN1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RMDN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMDN1 Gene

Disorders for RMDN1 Gene

Relevant External Links for RMDN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RMDN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMDN1 Gene

Publications for RMDN1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K. … Sawa H. (J. Cell Biol. 2007) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for RMDN1 Gene

Sources for RMDN1 Gene

Loading form....