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Aliases for RMDN1 Gene

Aliases for RMDN1 Gene

  • Regulator Of Microtubule Dynamics 1 2 3 5
  • Family With Sequence Similarity 82, Member B 2 3
  • FAM82B 3 4
  • RMD-1 3 4
  • Regulator Of Microtubule Dynamics Protein 1 3
  • Microtubule-Associated Protein 3
  • Protein FAM82B 4
  • CGI-90 3
  • HRMD-1 4
  • RMD1 3

External Ids for RMDN1 Gene

Previous HGNC Symbols for RMDN1 Gene

  • FAM82B

Previous GeneCards Identifiers for RMDN1 Gene

  • GC08M087481

Summaries for RMDN1 Gene

GeneCards Summary for RMDN1 Gene

RMDN1 (Regulator Of Microtubule Dynamics 1) is a Protein Coding gene. An important paralog of this gene is RMDN3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN1 Gene

Genomics for RMDN1 Gene

Regulatory Elements for RMDN1 Gene

Enhancers for RMDN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G086341 1.1 ENCODE 24.4 +171.0 171001 4.3 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZBTB7B YY1 ZNF766 SP3 SP5 RMDN1 WWP1 LOC105375624
GH08G086507 1.1 ENCODE 23.4 +6.0 6008 2.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 RMDN1 WWP1 NTAN1P2 LOC105375624 CPNE3 SLC2A3P4
GH08G086319 1.1 Ensembl ENCODE 22.3 +194.0 194044 0.8 ELF3 FOXA2 JUN MAX CEBPG RAD21 RARA YY1 GATA3 HNF4G RMDN1 SLC7A13 LOC105375623
GH08G086513 1 ENCODE 24.3 -0.4 -412 1.8 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B GLIS2 ELK1 ZNF207 SP3 MXD4 RMDN1 CPNE3 MIOXP1
GH08G086522 1 Ensembl ENCODE 23 -8.7 -8745 1.7 PKNOX1 ESRRA CTBP1 ZNF316 FOSL2 RELB FOS IKZF2 MAFK MTA2 RMDN1 CPNE3 MIOXP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RMDN1 on UCSC Golden Path with GeneCards custom track

Promoters for RMDN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226631 -443 1201 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B GLIS2 ELK1 ZNF207 SP3 MXD4

Genomic Location for RMDN1 Gene

Chromosome:
8
Start:
86,467,398 bp from pter
End:
86,514,357 bp from pter
Size:
46,960 bases
Orientation:
Minus strand

Genomic View for RMDN1 Gene

Genes around RMDN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMDN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN1 Gene

Proteins for RMDN1 Gene

  • Protein details for RMDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DB5-RMD1_HUMAN
    Recommended name:
    Regulator of microtubule dynamics protein 1
    Protein Accession:
    Q96DB5
    Secondary Accessions:
    • A9UMZ8
    • B4DNF5
    • B4DZW6
    • B5MC61
    • C9JSC6
    • E7EVI2
    • Q9Y398

    Protein attributes for RMDN1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35808 Da
    Quaternary structure:
    • Interacts with microtubules.

    Alternative splice isoforms for RMDN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RMDN1 Gene

Post-translational modifications for RMDN1 Gene

  • Ubiquitination at isoforms=2, 3230, isoforms=2, 3243, and isoforms=2261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RMDN1 Gene

Domains & Families for RMDN1 Gene

Protein Domains for RMDN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RMDN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96DB5

UniProtKB/Swiss-Prot:

RMD1_HUMAN :
  • Belongs to the RMDN family.
Family:
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN1: view

No data available for Gene Families for RMDN1 Gene

Function for RMDN1 Gene

genes like me logo Genes that share phenotypes with RMDN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMDN1 Gene

Localization for RMDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMDN1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RMDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with RMDN1: view

Pathways & Interactions for RMDN1 Gene

SuperPathways for RMDN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RMDN1 Gene

Transcripts for RMDN1 Gene

Unigene Clusters for RMDN1 Gene

Regulator of microtubule dynamics 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN1 Gene

No ASD Table

Relevant External Links for RMDN1 Gene

GeneLoc Exon Structure for
RMDN1
ECgene alternative splicing isoforms for
RMDN1

Expression for RMDN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RMDN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RMDN1 Gene

This gene is overexpressed in Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RMDN1 Gene



Protein tissue co-expression partners for RMDN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RMDN1 Gene:

RMDN1

SOURCE GeneReport for Unigene cluster for RMDN1 Gene:

Hs.145386

Evidence on tissue expression from TISSUES for RMDN1 Gene

  • Pancreas(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with RMDN1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMDN1 Gene

Orthologs for RMDN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM82B 34
  • 99.58 (n)
RMDN1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM82B 34
  • 88.85 (n)
RMDN1 35
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RMDN1 34 35
  • 86.94 (n)
mouse
(Mus musculus)
Mammalia Rmdn1 34 16 35
  • 86.34 (n)
rat
(Rattus norvegicus)
Mammalia Rmdn1 34
  • 86.24 (n)
oppossum
(Monodelphis domestica)
Mammalia RMDN1 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RMDN1 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM82B 34 35
  • 72.79 (n)
lizard
(Anolis carolinensis)
Reptilia RMDN1 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn1 34
  • 62.28 (n)
Str.15080 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64464 34
zebrafish
(Danio rerio)
Actinopterygii zgc:171674 34
  • 62.34 (n)
RMDN1 35
  • 52 (a)
OneToOne
Dr.12839 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9264 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012364 34
  • 46.19 (n)
worm
(Caenorhabditis elegans)
Secernentea F33H2.6 34 35
  • 49.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
Species where no ortholog for RMDN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN1 Gene

ENSEMBL:
Gene Tree for RMDN1 (if available)
TreeFam:
Gene Tree for RMDN1 (if available)

Paralogs for RMDN1 Gene

Paralogs for RMDN1 Gene

genes like me logo Genes that share paralogs with RMDN1: view

Variants for RMDN1 Gene

Sequence variations from dbSNP and Humsavar for RMDN1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000210785 -- 86,509,157(+) TCAAG(G/T)GGGTA intron-variant, upstream-variant-2KB
rs1000245737 -- 86,504,532(+) ATACT(A/G)TCTTC intron-variant
rs1000256821 -- 86,481,062(+) TTCAT(A/G)TTAAA intron-variant
rs1000286794 -- 86,512,443(+) GCCCC(C/T)GCTAC intron-variant, upstream-variant-2KB
rs1000299350 -- 86,504,278(+) GGGCA(C/G)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RMDN1 Gene

Variant ID Type Subtype PubMed ID
nsv1023510 CNV loss 25217958
nsv971681 CNV duplication 23825009

Variation tolerance for RMDN1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RMDN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RMDN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMDN1 Gene

Disorders for RMDN1 Gene

Relevant External Links for RMDN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RMDN1

No disorders were found for RMDN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMDN1 Gene

Publications for RMDN1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K. … Sawa H. (J. Cell Biol. 2007) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for RMDN1 Gene

Sources for RMDN1 Gene

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