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Aliases for RLTPR Gene

Aliases for RLTPR Gene

  • RGD Motif, Leucine Rich Repeats, Tropomodulin Domain And Proline-Rich Containing 2 3
  • RGD, Leucine-Rich Repeat, Tropomodulin And Proline-Rich-Containing Protein 3 4
  • Leucine Rich Repeat Containing 16C 2 3
  • CARMIL2b 3 4
  • LRRC16C 3 4
  • RGD, Leucine-Rich Repeat, Tropomodulin And Proline-Rich Containing Protein 3
  • Tropomodulin And Proline-Rich Containing Protein 2
  • Leucine-Rich Repeat 2
  • CARMIL2 3
  • RGD 2

External Ids for RLTPR Gene

Previous GeneCards Identifiers for RLTPR Gene

  • GC16P066231
  • GC16P053551

Summaries for RLTPR Gene

GeneCards Summary for RLTPR Gene

RLTPR (RGD Motif, Leucine Rich Repeats, Tropomodulin Domain And Proline-Rich Containing) is a Protein Coding gene. An important paralog of this gene is LRRC16A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RLTPR Gene

Genomics for RLTPR Gene

Regulatory Elements for RLTPR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RLTPR Gene

Chromosome:
16
Start:
67,644,919 bp from pter
End:
67,657,569 bp from pter
Size:
12,651 bases
Orientation:
Plus strand

Genomic View for RLTPR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RLTPR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RLTPR Gene

Proteins for RLTPR Gene

  • Protein details for RLTPR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6F5E8-LR16C_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 16C
    Protein Accession:
    Q6F5E8
    Secondary Accessions:
    • B8X2Z3

    Protein attributes for RLTPR Gene

    Size:
    1435 amino acids
    Molecular mass:
    154689 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD26751.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RLTPR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RLTPR Gene

Proteomics data for RLTPR Gene at MOPED

Post-translational modifications for RLTPR Gene

  • Ubiquitination at Lys 563, Lys 595, and Lys 668
  • Modification sites at PhosphoSitePlus

Other Protein References for RLTPR Gene

No data available for DME Specific Peptides for RLTPR Gene

Domains & Families for RLTPR Gene

Protein Domains for RLTPR Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RLTPR Gene

Graphical View of Domain Structure for InterPro Entry

Q6F5E8

UniProtKB/Swiss-Prot:

LR16C_HUMAN :
  • Belongs to the CARMIL family.
  • Contains 16 LRR (leucine-rich) repeats.
Family:
  • Belongs to the CARMIL family.
Similarity:
  • Contains 16 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with RLTPR: view

No data available for Gene Families for RLTPR Gene

Function for RLTPR Gene

Gene Ontology (GO) - Molecular Function for RLTPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RLTPR: view

Phenotypes for RLTPR Gene

GenomeRNAi human phenotypes for RLTPR:
genes like me logo Genes that share phenotypes with RLTPR: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RLTPR

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RLTPR Gene

Localization for RLTPR Gene

Subcellular locations from UniProtKB/Swiss-Prot for RLTPR Gene

Cytoplasm. Note=Exhibits a fibrillar pattern reminiscent of intermediate filaments. Colocalizes with vimentin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RLTPR Gene COMPARTMENTS Subcellular localization image for RLTPR gene
Compartment Confidence
cytoskeleton 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for RLTPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005737 cytoplasm IEA --
GO:0005911 cell-cell junction IEA --
GO:0008290 F-actin capping protein complex IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RLTPR: view

Pathways & Interactions for RLTPR Gene

SuperPathways for RLTPR Gene

No Data Available

Interacting Proteins for RLTPR Gene

Gene Ontology (GO) - Biological Process for RLTPR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016477 cell migration --
GO:0030011 maintenance of cell polarity --
GO:0032729 positive regulation of interferon-gamma production --
GO:0042102 positive regulation of T cell proliferation IEA --
GO:0045184 establishment of protein localization IEA --
genes like me logo Genes that share ontologies with RLTPR: view

No data available for Pathways by source and SIGNOR curated interactions for RLTPR Gene

Drugs & Compounds for RLTPR Gene

No Compound Related Data Available

Transcripts for RLTPR Gene

Unigene Clusters for RLTPR Gene

RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RLTPR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RLTPR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a ·
SP1: - - - - - -
SP2: - -
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31a · 31b · 31c ^ 32 ^ 33
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for RLTPR Gene

GeneLoc Exon Structure for
RLTPR
ECgene alternative splicing isoforms for
RLTPR

Expression for RLTPR Gene

mRNA expression in normal human tissues for RLTPR Gene

mRNA differential expression in normal tissues according to GTEx for RLTPR Gene

This gene is overexpressed in Spleen (x4.8) and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for RLTPR Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.8), CD8 Tcells (15.1), and Frontal cortex (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RLTPR Gene



SOURCE GeneReport for Unigene cluster for RLTPR Gene Hs.611432

mRNA Expression by UniProt/SwissProt for RLTPR Gene

Q6F5E8-LR16C_HUMAN
Tissue specificity: Expressed in all tissues tested, including thymus, spleen, colon, leukocytes, peripheral blood, skin, skin keratinocytes and skin fibroblasts.
genes like me logo Genes that share expression patterns with RLTPR: view

Protein tissue co-expression partners for RLTPR Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RLTPR Gene

Orthologs for RLTPR Gene

This gene was present in the common ancestor of animals.

Orthologs for RLTPR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RLTPR 35
  • 88.83 (n)
  • 90.42 (a)
RLTPR 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rltpr 35
  • 85.46 (n)
  • 86.45 (a)
Rltpr 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rltpr 35
  • 84.64 (n)
  • 87.14 (a)
dog
(Canis familiaris)
Mammalia RLTPR 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RLTPR 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RLTPR 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RLTPR 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves RLTPR 35
  • 60.41 (n)
  • 51.63 (a)
RLTPR 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RLTPR 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491722 35
  • 51.45 (n)
  • 45.81 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-6e12.4 35
  • 53.74 (n)
  • 44.2 (a)
RLTPR 36
  • 29 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1399 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crml-1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
ManyToMany
Species with no ortholog for RLTPR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RLTPR Gene

ENSEMBL:
Gene Tree for RLTPR (if available)
TreeFam:
Gene Tree for RLTPR (if available)

Paralogs for RLTPR Gene

Paralogs for RLTPR Gene

(3) SIMAP similar genes for RLTPR Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for RLTPR Gene

genes like me logo Genes that share paralogs with RLTPR: view

Variants for RLTPR Gene

Sequence variations from dbSNP and Humsavar for RLTPR Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1212490 -- 67,649,433(-) GGCTT(G/T)CTCTT intron-variant, upstream-variant-2KB
rs7195415 -- 67,655,154(+) ggcca(A/G)gcgcc intron-variant
rs7200950 -- 67,655,849(+) GAAGT(C/T)GGCCT intron-variant
rs7498662 -- 67,644,608(+) gggat(A/T)acagg upstream-variant-2KB
rs8044797 -- 67,656,548(+) GGCCC(C/T)CCCTC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for RLTPR Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
dgv2890n71 CNV Loss 21882294
nsv906809 CNV Loss 21882294
dgv2891n71 CNV Loss 21882294

Variation tolerance for RLTPR Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.94; 67.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RLTPR Gene

HapMap Linkage Disequilibrium report
RLTPR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RLTPR Gene

Disorders for RLTPR Gene

Relevant External Links for RLTPR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RLTPR
genes like me logo Genes that share disorders with RLTPR: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RLTPR Gene

Publications for RLTPR Gene

  1. Identification, expression analysis and polymorphism of a novel RLTPR gene encoding a RGD motif, tropomodulin domain and proline/leucine- rich regions. (PMID: 15588584) Matsuzaka Y. … Inoko H. (Gene 2004) 2 23 67
  2. Distinct roles for CARMIL isoforms in cell migration. (PMID: 19846667) Liang Y. … Cooper J.A. (Mol. Biol. Cell 2009) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 67

Products for RLTPR Gene

Sources for RLTPR Gene

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