Aliases for RLN3 Gene
External Ids for RLN3 Gene
Previous GeneCards Identifiers for RLN3 Gene
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes. [provided by RefSeq, Jul 2008]
GeneCards Summary for RLN3 Gene
RLN3 (Relaxin 3) is a Protein Coding gene. Diseases associated with RLN3 include tick infestation. Among its related pathways are Signaling by GPCR and CREB Pathway. GO annotations related to this gene include hormone activity and G-protein coupled receptor binding.
UniProtKB/Swiss-Prot for RLN3 Gene
May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142)