RLN3 Gene
protein-coding GIFtS: 49
GCID: GC19P014137
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relaxin 3(Previous name: relaxin 3 (H3) )
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Aliases
for RLN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Relaxin 31 2 | | Prorelaxin H32 3 | | RXN31 2 3 5 | | Relaxin 3 (H3)1 | | ZINS41 2 3 | | Insl71 | | H31 2 5 | | Insulin-Like 72 | | Insulin-Like Peptide 72 3 | | Relaxin-31 | | Insulin-Like Peptide INSL72 3 | | INSL73 |
Export aliases for RLN3 gene to outside databasesPrevious GC identifers: GC19P014494 GC19P013984 GC19P014000 GC19P013711 |
Summaries
for RLN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RLN3:
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the humanthere are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin isproduced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysisand inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure,controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of therelaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sitesare not definitely described yet. It may play a role in neuropeptide signaling processes. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: REL3_HUMAN, Q8WXF3Function: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) andrelaxin-3 receptor-2 (GPCR142)
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Genomic Views
for RLN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RLN3 gene promoter:
TBP NF-1 NF-1/L E47 GATA-1 AREB6 PPAR-gamma1 GATA-6 STAT3 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for RLN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RLN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.2RLN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P014137: view genomic region
(about GC identifiers)
Start:
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14,138,960 bp from pter |
End:
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14,141,854 bp from pter |
Size:
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2,895 bases |
Orientation:
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plus strand |
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Proteins
for RLN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: REL3_HUMAN, Q8WXF3 (See
protein sequence)Recommended Name: Relaxin-3 precursor Size: 142 amino acids; 15451 Da
Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds
Subcellular location: Secreted
Sequence caution: Sequence=AAQ88548.1; Type=Erroneous initiation;
2 PDB 3D structures from  and Proteopedia  for RLN3:2FHW (3D)
2K1V (3D)
Secondary accessions: Q6UXW5Explore the universe of human proteins at neXtProt for RLN3: NX_Q8WXF3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WXF3
RLN3 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_543140.1
ENSEMBL proteins: ENSP00000397415 ENSP00000467130 Reactome Protein details: Q8WXF3
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
TAS | -- |
RLN3 for ontologies About GeneDecksing
RLN3 Antibody Products:
Assay Products for RLN3: |
Protein
Domains /
Families
for RLN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RLN3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WXF3ProtoNet protein and cluster: Q8WXF3 1 Blocks protein family: IPB004825 Insulin/IGF/relaxin
UniProtKB/Swiss-Prot: REL3_HUMAN, Q8WXF3Similarity: Belongs to the insulin family |
Function
for RLN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: REL3_HUMAN, Q8WXF3Function: May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) andrelaxin-3 receptor-2 (GPCR142)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RLN3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RLN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RLN3 (NM_080864) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RLN3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLN3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001664 | G-protein coupled receptor binding |
IEA | -- | | GO:0005179 | hormone activity |
IEA | -- |
RLN3 for ontologies About GeneDecksing
Animal Models:
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rln3):
RLN3 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RLN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Signaling by GPCR | | | 3 | Relaxin receptors | | | 4 | CREB Pathway | | | 5 | G-Beta Gamma Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RLN3
5/9 
Reactome Pathways for RLN3 (see all 9)
RLN3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RLN3
2 Interacting proteins for RLN3 (Q8WXF33) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for RLN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RLN3 for compounds About GeneDecksing
 Browse Tocris compounds for RLN3
1 Novoseek chemical compound relationship for RLN3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenylate |
17.5 |
1 |
14522967 (1) |
Search CenterWatch for drugs/clinical trials and news about RLN3 / REL3
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Transcripts
for RLN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RLN3 gene: NM_080864.2 Unigene Cluster for RLN3: Relaxin 3 Hs.352155 [show with all ESTs]Unigene Representative Sequence: AY3581812 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000431365(uc002mxw.1 uc010dzj.1) ENST00000585987
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RLN3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RLN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RLN3 (NM_080864) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RLN3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLN3 |
Additional cDNA sequence: AB076563.1 AF447451.1 AY358181.1 BC110069.1 BC140935.1 2 DOTS entries: DT.108308 DT.121504421 24/81 AceView cDNA sequences (see all 81): BF829683 BM762764 BM760781 BM804052 AB076563 BM764289 AI347487 NM_080864 BP337994 BC028003 AF106912 BU632122 AI769137 NM_004843 AF447451 AW575269 CA426655 BM761233 BQ919454 BF829689 BG756941 BF984779 AW295066 BM842397
GeneLoc Exon Structure
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Expression
for RLN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RLN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCTGGCCC
About this image
Genevestigator expression for RLN3
SOURCE GeneReport for Unigene cluster: Hs.352155
SABiosciences Custom PCR Arrays for RLN3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RLN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RLN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RLN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RLN3 |
Orthologs
for RLN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RLN3 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for RLN3 (if available)
TreeFam Gene Tree for RLN3 (if available) |
Paralogs
for RLN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RLN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RLN3 (14138960 - 14141854 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RLN3
1 CNV: 5089 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RLN3 |
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Disorders
/ Diseases
for RLN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RLN3 for disorders About GeneDecksing
OMIM gene information: 606855
OMIM disorders: --
3  diseases for RLN3: About MalaCardstick infestation hepatitis neuronitis
1 disease from the University of Copenhagen DISEASES database for RLN3:Tick infestation Human Genome Epidemiology (HuGE) Navigator: RLN3 (1 document)
Export disorders for RLN3 gene to outside databases
|
Publications
for RLN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RLN3 gene, integrated from 9 sources (see all 77):
(articles sorted by number of sources associating them with RLN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Production of recombinant human relaxin 3 in AtT20 cells. (PubMed id 12686464)1, 2, 9 Kizawa H.... Fujino M. (2003)
- Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135. (PubMed id 14522968)1, 2, 9 Liu C.... Lovenberg T.W. (2003)
- Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. (PubMed id 16365033)1, 2, 9 Rosengren K.J....Craik D.J. (2006)
- Identification of relaxin-3/INSL7 as a ligand for GPCR142. (PubMed id 14522967)1, 2, 9 Liu C....Lovenberg T.W. (2003)
- H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. (PubMed id 12506116)1, 2, 9 Sudo S.... Hsueh A.J.W. (2003)
- Central relaxin-3 administration causes hyperphagia in male Wistar rats. (PubMed id 15845619)1, 9 McGowan B.M....Bloom S.R. (2005)
- The chemistry and biology of human relaxin-3. (PubMed id 15956686)1, 9 Tregear G.W....Wade J.D. (2005)
- Relaxin-3 and receptors in the human and rhesus brain and reproductive tissues. (PubMed id 19778557)1, 9 Silvertown J.D....Medin J.A. (2010)
- Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. (PubMed id 15465925)1, 9 Liu C....Lovenberg T.W. (2005)
- The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5. (PubMed id 19152634)1, 9 Hossain M.A....Wade J.D. (2009)
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External Searches for RLN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RLN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RLN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RLN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RLN3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RLN3 gene:
Search GeneIP for patents involving RLN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RLN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RLN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RLN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RLN3 | | | OriGene Protein Over-expression Lysate for RLN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RLN3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RLN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RLN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RLN3 | | OriGene Custom Protein Services for RLN3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RLN3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RLN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RLN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RLN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RLN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RLN3 |
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 | | | RLN3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RLN3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLN3 |
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