Aliases for RLN2 Gene
External Ids for RLN2 Gene
Previous GeneCards Identifiers for RLN2 Gene
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013]
GeneCards Summary for RLN2 Gene
RLN2 (Relaxin 2) is a Protein Coding gene. Diseases associated with RLN2 include anterior cruciate ligament tears and bone squamous cell carcinoma. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity. An important paralog of this gene is RLN1.
UniProtKB/Swiss-Prot for RLN2 Gene
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.