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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RLN2 Gene

protein-coding   GIFtS: 57
GCID: GC09M005305

Relaxin 2

(Previous name: relaxin 2 (H2))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Relaxin 21 2     H22
Prorelaxin H21 2     H2-RLX2
Of Pregnancy1     H2-preprorelaxin2
ovarian1     RLXH22
relaxin1     bA12D24.1.12
Relaxin 2 (H2)1     bA12D24.1.22
Relaxin H21     Relaxin, Ovarian, Of Pregnancy2

External Ids:    HGNC: 100271   Entrez Gene: 60192   Ensembl: ENSG000001070147   OMIM: 1797405   UniProtKB: P040903   

Export aliases for RLN2 gene to outside databases

Previous GC identifers: GC09M005453 GC09M005281 GC09M005289 GC09M005301


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RLN2 Gene:
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In
humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence
homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by
disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the
cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing
sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin.
Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Jan 2013)

GeneCards Summary for RLN2 Gene: 
RLN2 (relaxin 2) is a protein-coding gene. Diseases associated with RLN2 include anterior cruciate ligament tears, and prostate cancer, progression of, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include hormone activity. An important paralog of this gene is RLN1.

UniProtKB/Swiss-Prot: REL2_HUMAN, P04090
Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many
mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic
ligaments and ripening of the cervix




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RLN2 gene promoter:
         Nkx3-1 v2   Nkx3-1   Sox5   PPAR-gamma1   AML1a   Nkx3-1 v3   Nkx3-1 v1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRLN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for RLN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

RLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RLN2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M005305:  view genomic region     (about GC identifiers)

Start:
5,299,868 bp from pter      End:
5,304,969 bp from pter
Size:
5,102 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REL2_HUMAN, P04090 (See protein sequence)
Recommended Name: Prorelaxin H2 precursor  
Size: 185 amino acids; 21043 Da
Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for RLN2:
6RLX (3D)    
Secondary accessions: A0AVM0 Q99936 Q9UCX3 Q9UQJ2
Alternative splicing: 2 isoforms:  P04090-1   P04090-2   

Explore the universe of human proteins at neXtProt for RLN2: NX_P04090

Explore proteomics data for RLN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04090

  • RLN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RLN2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_005050.2  NP_604390.1  

    ENSEMBL proteins: 
     ENSP00000371040   ENSP00000399616   ENSP00000308018  
    Reactome Protein details: P04090
    Human Recombinant Protein Products for RLN2: 
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    Novus Biologicals RLN2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RLN2
    Cloud-Clone Corp. Proteins for RLN2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    RLN2 for ontologies           About GeneDecksing



    RLN2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RLN2 
    Cloud-Clone Corp. CLIAs for RLN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR016179 Insulin-like
     IPR022352 Insulin_family
     IPR022421 Relaxin
     IPR022353 Insulin_CS

    Graphical View of Domain Structure for InterPro Entry P04090

    ProtoNet protein and cluster: P04090

    1 Blocks protein domain: IPB004825 Insulin/IGF/relaxin

    UniProtKB/Swiss-Prot: REL2_HUMAN, P04090
    Similarity: Belongs to the insulin family


    RLN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REL2_HUMAN, P04090
    Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many
    mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic
    ligaments and ripening of the cervix

         Genatlas biochemistry entry for RLN2:
    relaxin 2 (H2)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
         
    RLN2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RLN2:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RLN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RLN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RLN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RLN2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RLN2
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    SwitchGear 3'UTR luciferase reporter plasmidRLN2 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RLN2 (NM_134441)
    Sino Biological Human cDNA Clone for RLN2
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    Search LifeMap BioReagents cell lines for RLN2
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RLN2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3CREB Pathway
    Activation of PKC through GPCR0.63
    4G-Beta Gamma Signaling
    Relaxin Pathway0.37
    5Prostacyclin signalling through prostacyclin receptor
    G alpha (s) signalling events0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RLN2
        Relaxin Pathway
    Activation of PKC through GPCR


    5/8        Reactome Pathways for RLN2 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)



    RLN2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RLN2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RLN2 (P040903 ENSP000003710404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RXFP2Q8WXD03, ENSP000002983864I2D: score=1 STRING: ENSP00000298386
    RXFP1Q9HBX93, ENSP000003032484I2D: score=1 STRING: ENSP00000303248
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007565female pregnancy TAS6548702

    RLN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RLN2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RLN2 (REL2)

    1 Novoseek inferred chemical compound relationship for RLN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 1.99 3 15956723 (2), 15956719 (1)

    Search CenterWatch for drugs/clinical trials and news about RLN2 / REL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RLN2 gene (2 alternative transcripts): 
    NM_005059.3  NM_134441.2  

    Unigene Cluster for RLN2:

    Relaxin 2
    Hs.127032  [show with all ESTs]
    Unigene Representative Sequence: NM_005059
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381627(uc003zja.1) ENST00000416837 ENST00000308420(uc003ziz.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RLN2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RLN2
    SwitchGear 3'UTR luciferase reporter plasmidRLN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RLN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RLN2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLN2
    Sirion Biotech Customized lentivirus for stable overexpression of RLN2 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RLN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RLN2

    Additional mRNA sequence: 

    AF057706.1 BC126415.1 BC126419.1 X00948.1 

    2 DOTS entries:

    DT.203337  DT.99983463 

    10 AceView cDNA sequences:

    NM_134441 NM_005059 X00948 AA935560 BX094853 AI033912 BF513584 AV753250 
    BG206251 AF057706 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RLN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTTGTAC
    RLN2 Expression
    About this image


    See RLN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RLN2

    SOURCE GeneReport for Unigene cluster: Hs.127032

    UniProtKB/Swiss-Prot: REL2_HUMAN, P04090
    Tissue specificity: Isoform 1 is expressed in the ovary during pregnancy. Also expressed in placenta, decidua and
    prostate. Isoform 2 is relatively abundant in placenta. It is in much lower abundance in the prostate gland. Not
    detected in the ovary

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for RLN2 (if available)
    TreeFam Gene Tree for RLN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RLN2 gene
    RLN12  
    1 SIMAP similar gene for RLN2 using alignment to 2 protein entries:     REL2_HUMAN (see all proteins):
    RLN1

    RLN2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/211 SNPs in RLN2 are shown (see all 211)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0221244
    ----see VAR_0221242 P Q mis40--------
    rs109750431,2
    C,F,A,H--5299385(+) TTTTTC/ATCCTT 2 -- ds500121Minor allele frequency- A:0.32NS EA NA WA CSA 2216
    rs1809473481,2
    C--5299420(+) CTTAGA/TCACTG 2 -- ds50010--------
    rs1493105741,2
    --5299480(+) CTATAC/GTAGAA 2 -- ds50010--------
    rs1863159381,2
    C--5299514(+) AAAAGC/TGTTTG 2 -- ds50010--------
    rs1445509081,2
    C--5299515(+) AAAGCA/GTTTGA 2 -- ds50010--------
    rs1421751851,2
    --5299631(+) GTCAAC/GTTTTA 2 -- ds50010--------
    rs1910605161,2
    --5299648(+) TATCTA/GTATCC 2 -- ds50010--------
    rs558587481,2
    C,F--5299655(+) ATCCAA/GTCTAA 2 -- ds500110Minor allele frequency- G:0.18WA NA CSA EA 372
    rs1834692221,2
    --5299691(+) GTCCAC/TTTCAT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for RLN2 (5299868 - 5304969 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for RLN2 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831495CNV Loss17160897
    dgv8017n71CNV Loss21882294
    nsv466102CNV Loss19166990
    nsv824828CNV Loss20364138
    nsv892145CNV Gain21882294
    nsv892136CNV Gain21882294
    nsv527495CNV Gain19592680
    nsv892141CNV Gain21882294
    nsv516752CNV Gain+Loss19592680
    dgv8019n71CNV Gain+Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RLN2
    DNA2.0 Custom Variant and Variant Library Synthesis for RLN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179740    OMIM disorders: --

    16 diseases for RLN2:    About MalaCards
    anterior cruciate ligament tears    prostate cancer, progression of    scleroderma    acute myocardial infarction
    myocardial infarction    leiomyoma    diabetes mellitus    prostate cancer
    type 1 diabetes    hepatitis b    periodontitis    thyroiditis
    prostatitis    breast cancer    hypertension    hepatitis


    RLN2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for RLN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 5 19416221 (2), 15956747 (1), 18718015 (1)
    tumors 0 14 16049981 (5), 17197386 (2)

    Genetic Association Database (GAD): RLN2
    Human Genome Epidemiology (HuGE) Navigator: RLN2 (2 documents)

    Export disorders for RLN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RLN2 gene, integrated from 9 sources (see all 127):
    (articles sorted by number of sources associating them with RLN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones. (PubMed id 6548702)1, 2, 3 Hudson P.... Niall H. (1984)
    2. Polymorphisms in the promoter region of relaxin-2 and preterm birth: involvement of relaxin in the etiology of preterm birth. (PubMed id 20023247)1, 4, 9 Vogel I....Grove J. (2009)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping. (PubMed id 10601981)1, 2 Garibay-Tupas J.L....Bryant-Greenwood G.D. (1999)
    6. Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species. (PubMed id 8735594)1, 2 Gunnersen J.M.... Tregear G.W. (1996)
    7. Human seminal relaxin is a product of the same gene as human luteal relaxin. (PubMed id 1572287)1, 2 Winslow J.W....Goldsmith L.T. (1992)
    8. Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination. (PubMed id 2040595)1, 2 Buellesbach E.E. and Schwabe C. (1991)
    9. X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants. (PubMed id 1656049)1, 2 Eigenbrot C.... Kossiakoff A.A. (1991)
    10. Structural characterization by mass spectrometry of native and recombinant human relaxin. (PubMed id 2076464)1, 2 Winslow J.W.... Vandlen R.L. (1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6019 HGNC: 10027 AceView: RLN2 Ensembl:ENSG00000107014 euGenes: HUgn6019
    ECgene: RLN2 H-InvDB: RLN2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RLN2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RLN2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RLN2 gene:
    Search GeneIP for patents involving RLN2

    GeneCards and IP:
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