Aliases for RLN2 Gene
External Ids for RLN2 Gene
Previous GeneCards Identifiers for RLN2 Gene
This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]
GeneCards Summary for RLN2 Gene
RLN2 (Relaxin 2) is a Protein Coding gene. Diseases associated with RLN2 include Anterior Cruciate Ligament Tears and Bone Squamous Cell Carcinoma. Among its related pathways are CREB Pathway and Signaling by GPCR. GO annotations related to this gene include hormone activity. An important paralog of this gene is RLN1.
UniProtKB/Swiss-Prot for RLN2 Gene
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.