Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RLN1 Gene

protein-coding   GIFtS: 51
GCID: GC09M005324

Relaxin 1

(Previous name: relaxin 1 (H1))
  See RLN1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Relaxin 11 2     RLXH12
Prorelaxin H11 2     bA12D24.3.12
Relaxin 1 (H1)1     bA12D24.3.22
H12     Preprorelaxin H12
H1RLX2     

External Ids:    HGNC: 100261   Entrez Gene: 60132   Ensembl: ENSG000001070187   OMIM: 1797305   UniProtKB: P048083   

Export aliases for RLN1 gene to outside databases

Previous GC identifers: GC09M005488 GC09M005316


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RLN1 Gene:
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In
humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence
homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form
consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the
mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction.
It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and
releasing oxytocin and vasopressin. (provided by RefSeq, Jan 2013)

GeneCards Summary for RLN1 Gene:
RLN1 (relaxin 1) is a protein-coding gene. Diseases associated with RLN1 include preterm premature rupture of the membranes. GO annotations related to this gene include hormone activity. An important paralog of this gene is RLN2.

UniProtKB/Swiss-Prot: REL1_HUMAN, P04808
Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many
mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic
ligaments and ripening of the cervix




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RLN1 gene promoter:
         Nkx3-1   RFX1   Nkx3-1 v4   LHX3b/Lhx3b   AML1a   Nkx3-1 v1   C/EBPalpha   Nkx3-1 v2   LHX3a/Lhx3a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRLN1 promoter sequence
   Search Chromatin IP Primers for RLN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RLN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

RLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RLN1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M005324:  view genomic region     (about GC identifiers)

Start:
5,334,969 bp from pter      End:
5,339,873 bp from pter
Size:
4,905 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: REL1_HUMAN, P04808 (See protein sequence)
Recommended Name: Prorelaxin H1 precursor  
Size: 185 amino acids; 21146 Da
Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds
Secondary accessions: Q99936 Q9UQJ1
Alternative splicing: 2 isoforms:  P04808-1   P04808-2   

Explore the universe of human proteins at neXtProt for RLN1: NX_P04808

Explore proteomics data for RLN1 at MOPED


See RLN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_008842.1  
ENSEMBL proteins: 
 ENSP00000223862   ENSP00000223858  

RLN1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
R&D Systems Recombinant & Natural Proteins for RLN1 (Relaxin-1)
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for RLN1
OriGene Custom MassSpec
OriGene Custom Protein Services for RLN1
GenScript Custom Purified and Recombinant Proteins Services for RLN1
Novus Biologicals RLN1 Protein
Novus Biologicals RLN1 Lysates
Sino Biological Recombinant Protein for RLN1
Sino Biological Cell Lysate for RLN1
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for RLN1 

 
antibodies-online proteins for RLN1 (7 products) 

 
antibodies-online peptides for RLN1

RLN1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
R&D Systems Antibodies for RLN1 (Relaxin-1)
OriGene Antibodies for RLN1
OriGene Custom Antibody Services for RLN1
Novus Biologicals RLN1 Antibodies
Abcam antibodies for RLN1
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for RLN1
antibodies-online antibodies for RLN1 (52 products) 

RLN1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for RLN1
R&D Systems ELISAs for RLN1 (Relaxin-1)
GenScript Custom Assay Services for RLN1
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for RLN1 
antibodies-online kits for RLN1 (18 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
ENDOLIG: Endogenous ligands

4 InterPro protein domains:
 IPR016179 Insulin-like
 IPR022352 Insulin_family
 IPR022421 Relaxin
 IPR022353 Insulin_CS

Graphical View of Domain Structure for InterPro Entry P04808

ProtoNet protein and cluster: P04808

1 Blocks protein domain: IPB004825 Insulin/IGF/relaxin

UniProtKB/Swiss-Prot: REL1_HUMAN, P04808
Similarity: Belongs to the insulin family


Find genes that share domains with RLN1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: REL1_HUMAN, P04808
Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many
mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic
ligaments and ripening of the cervix

     Genatlas biochemistry entry for RLN1:
relaxin 1 (H1)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
     
Find genes that share ontologies with RLN1           About GenesLikeMe


Phenotypes:
     9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rln1):
 behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
 integument  mortality/aging  reproductive system  skeleton 

Find genes that share phenotypes with RLN1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Rln1tm1Wint for RLN1

   genOway: Develop your customized and physiologically relevant rodent model for RLN1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat RLN1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RLN1
SwitchGear 3'UTR luciferase reporter plasmidRLN1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RLN1
Predesigned siRNA for gene silencing in human, mouse, rat RLN1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RLN1

Clone
Products:
     
OriGene clones in human, mouse for RLN1 (see all 6)
OriGene ORF clones in mouse, rat for RLN1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RLN1 (NM_006911)
Sino Biological Human cDNA Clone for RLN1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RLN1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLN1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for RLN1
Browse ESI BIO Cell Lines and PureStem Progenitors for RLN1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLN1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
REL1_HUMAN, P04808: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with RLN1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for RLN1 About    
See pathways by source

SuperPathContained pathways About
1CREB Pathway
Activation of PKC through GPCR0.63
2Myometrial Relaxation and Contraction Pathways
Myometrial Relaxation and Contraction Pathways0.43
3G-Beta Gamma Signaling
Relaxin Pathway0.37
4Androgen receptor signaling pathway
Androgen receptor signaling pathway

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RLN1
    Relaxin Pathway
Activation of PKC through GPCR

2 BioSystems Pathways for RLN1
    Myometrial Relaxation and Contraction Pathways
Androgen receptor signaling pathway



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RLN1
Interactions:

    GeneGlobe Interaction Network for RLN1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for RLN1 (P048083 ENSP000002238624) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
RNF6Q9Y2523, ENSP000003421214I2D: score=1 STRING: ENSP00000342121
RXFP1Q9HBX93, ENSP000003032484I2D: score=1 STRING: ENSP00000303248
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007165signal transduction NAS6298628
GO:0007565female pregnancy NAS6298628

Find genes that share ontologies with RLN1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RLN1 (REL1)

7 Novoseek inferred chemical compound relationships for RLN1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
preprorelaxin 87.4 1 1788398 (1)
progestin 56.9 1 8040838 (1)
c-peptide 36.3 6 1788398 (2), 8735594 (1), 9517397 (1)
histamine 35.1 8 10067839 (2), 8739345 (2), 11312281 (1), 10604529 (1)
nitric oxide 0 4 12237253 (1), 10604529 (1), 11003996 (1)
calcium 0 1 17158203 (1)
arginine 0 2 16467652 (1), 10604529 (1)



Find genes that share compounds with RLN1           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for RLN1 gene: 
NM_006911.3  

Unigene Cluster for RLN1:

Relaxin 1
Hs.368996  [show with all ESTs]
Unigene Representative Sequence: NM_006911
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000487557 ENST00000223862(uc003zjb.1) ENST00000223858
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RLN1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate RLN1
SwitchGear 3'UTR luciferase reporter plasmidRLN1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RLN1
Predesigned siRNA for gene silencing in human, mouse, rat RLN1
Clone
Products:
     
OriGene clones in human, mouse for RLN1 (see all 6)
OriGene ORF clones in mouse, rat for RLN1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: RLN1 (NM_006911)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RLN1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLN1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RLN1
OriGene qSTAR qPCR primer pairs in human, mouse for RLN1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RLN1
  QuantiTect SYBR Green Assays in human, mouse, rat RLN1
  QuantiFast Probe-based Assays in human, mouse, rat RLN1

Additional mRNA sequence: 

AF057705.1 BC005956.1 X00949.1 

1 DOTS entry:

DT.91722059 

15 AceView cDNA sequences:

BC005956 NM_006911 AA890637 X00949 AI089170 BF222091 AI452485 BX283911 
AF057705 BF681442 AI363233 BG195391 AA210817 AI004059 AA508353 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

RLN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGGAATTCA
RLN1 Expression
About this image

RLN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RLN1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.368996

UniProtKB/Swiss-Prot: REL1_HUMAN, P04808
Tissue specificity: Prostate. Not expressed in placenta, decidua or ovary

    Custom PCR Arrays for RLN1
Primer
Products:
OriGene qPCR primer pairs and template standards for RLN1
OriGene qSTAR qPCR primer pairs in human, mouse for RLN1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RLN1
QuantiTect SYBR Green Assays in human, mouse, rat RLN1
QuantiFast Probe-based Assays in human, mouse, rat RLN1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLN1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of human and mouse.

Orthologs for RLN1 gene from Selected species (see all 4)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rln11 , 5 relaxin 11, 5 63.75(n)1
49.73(a)1
  19 (23.83 cM)5
197731  NM_011272.21  NP_035402.21 
 293311705 


ENSEMBL Gene Tree for RLN1 (if available)
TreeFam Gene Tree for RLN1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for RLN1 gene
RLN22  
1 SIMAP similar gene for RLN1 using alignment to 1 protein entry:     REL1_HUMAN:
RLN2

Find genes that share paralogs with RLN1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for RLN1 (see all 193)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1165513061,2
F--5334483(+) ACAAGT/CGTTCA 1 -- ds50011Minor allele frequency- C:0.01WA 118
rs1869899801,2
--5334510(+) TTGCTC/TACAGA 1 -- ds50010--------
rs760944821,2
F--5334518(+) AGAAAT/CAGTAA 1 -- ds50011Minor allele frequency- C:0.01NA 120
rs1434687901,2
--5334542(+) GAACAA/TAAGGT 1 -- ds50010--------
rs1457715441,2
--5334640(+) AAAAGG/TAACTT 1 -- ds50010--------
rs776315001,2
C,F--5334796(+) CAAACT/CGATGG 1 -- ds50011Minor allele frequency- C:0.07WA 118
rs1929088221,2
--5334807(+) TTTGCA/CATGAG 1 -- ds50010--------
rs47420811,2
C,F,A,H--5334933(+) TGTAAC/GTGTTG 1 -- ut319Minor allele frequency- G:0.34NS EA WA NA CSA 644
rs600351701,2
C,F--5334946(+) AGGTAC/TTGTAT 1 -- ut312Minor allele frequency- T:0.04WA 120
rs1386142961,2
--5334962(+) TTATGC/TATGGT 1 -- ut310--------

HapMap Linkage Disequilibrium report for RLN1 (5334969 - 5339873 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RLN1 (see all 20):    About this table    
Variant IDTypeSubtypePubMed ID
esv2738159CNV Deletion23290073
nsv818675CNV Loss17921354
nsv466102CNV Loss19166990
nsv831495CNV Loss17160897
nsv466103CNV Loss19166990
dgv8020n71CNV Loss21882294
nsv892150CNV Loss21882294
nsv466106CNV Loss19166990
nsv824828CNV Loss20364138
nsv466104CNV Gain19166990

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RLN1
DNA2.0 Custom Variant and Variant Library Synthesis for RLN1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 179730    OMIM disorders: --

1 disease for RLN1:    
About MalaCards
preterm premature rupture of the membranes


Find genes that share disorders with RLN1           About GenesLikeMe

3 Novoseek inferred disease relationships for RLN1 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
prostatic adenocarcinoma 32.3 1 10750025 (1)
heart failure congestive 0.0309 1 16467652 (1)
heart failure 0 1 11641245 (1)

Genetic Association Database (GAD): RLN1
Human Genome Epidemiology (HuGE) Navigator: RLN1 (2 documents)

Export disorders for RLN1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for RLN1 gene, integrated from 10 sources (see all 111):
(articles sorted by number of sources associating them with RLN1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species. (PubMed id 8735594)1, 2, 9 Gunnersen J.M.... Tregear G.W. (Mol. Cell. Endocrinol. 1996)
  2. Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping. (PubMed id 10601981)1, 2, 9 Garibay-Tupas J.L....Bryant-Greenwood G.D. (J. Mol. Endocrinol. 1999)
  3. Polymorphisms in the promoter region of relaxin-2 and preterm birth: involvement of relaxin in the etiology of preterm birth. (PubMed id 20023247)1, 4, 9 Vogel I....Grove J. (In Vivo 2009)
  4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones. (PubMed id 6548702)1, 2 Hudson P.... Niall H. (EMBO J. 1984)
  7. Structure of a genomic clone encoding biologically active human relaxin. (PubMed id 6298628)1, 2 Hudson P.... Niall H. (Nature 1983)
  8. Isolation and analysis of the 3'-untranslated regions of the human relaxin H1 and H2 genes. (PubMed id 10750025)1, 9 Garibay-Tupas J.L....Bryant-Greenwood G.D. (J. Mol. Endocrinol. 2000)
  9. Adenovirus-mediated expression of human prorelaxin promotes the invasive potential of canine mammary cancer cells. (PubMed id 12865351)1, 9 Silvertown J.D....Summerlee A.J. (Endocrinology 2003)
  10. Characterization of human relaxin gene regulation in the relaxin-expressing human prostate adenocarcinoma cell line LNCaP.FGC. (PubMed id 8800640)1, 9 Gunnersen J.M....Crawford R.J. (J. Mol. Endocrinol. 1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 6013 HGNC: 10026 AceView: RLN1 Ensembl:ENSG00000107018 euGenes: HUgn6013
ECgene: RLN1 H-InvDB: RLN1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for RLN1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for RLN1 gene:
Search GeneIP for patents involving RLN1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Antibodies for RLN1 (Relaxin-1)   Browse Cell Culture Products  
 ELISAs for RLN1 (Relaxin-1)   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Recombinant/Natural Proteins for RLN1 (Relaxin-1)   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for RLN1   OriGene RNAi products in human, mouse, rat for RLN1  
 OriGene qPCR primer pairs and template standards for RLN1   OriGene Protein Over-expression Lysate for RLN1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for RLN1  
 OriGene qSTAR qPCR primer pairs in human, mouse for RLN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for RLN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for RLN1   OriGene Custom Protein Services for RLN1  

 
 
 Block miRNA regulation of human, mouse, rat RLN1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RLN1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RLN1 Predesigned siRNA for gene silencing in human, mouse, rat RLN1
 QuantiFast Probe-based Assays in human, mouse, rat RLN1 QuantiTect SYBR Green Assays in human, mouse, rat RLN1
 Custom PCR Arrays for RLN1 Search Chromatin IP Primers for RLN1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RLN1  GeneGlobe Interaction Network for RLN1
 Regulatory tfbs in RLN1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for RLN1 GenScript cDNA clones with any tag delivered in your preferred vector for RLN1
 GenScript Custom Assay Services for RLN1 GenScript Custom overexpressing Cell Line Services for RLN1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for RLN1 (REL1)
 Proteins for RLN1
 Cell Lysates for RLN1
 cDNA Clones for RLN1
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 RLN1 antibodies
 RLN1 proteins
 RLN1 lysates
 Antibodies for RLN1
 See all of Abcam's Antibodies, Kits and Proteins for RLN1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for RLN1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLN1
 SwitchGear 3'UTR luciferase reporter plasmids for RLN1
 SwitchGear Promoter luciferase reporter plasmids for RLN1
 Search ThermoFisher Antibodies for RLN1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLN1
 Browse compounds at ApexBio
 Search Addgene for plasmids for RLN1
  Search eBioscience for proteins for RLN1
  Search eBioscience for elisas for RLN1
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for RLN1
 antibodies-online antibodies for RLN1 (52 products)
 antibodies-online kits for RLN1 (18 products)
 antibodies-online peptides for RLN1
 antibodies-online proteins for RLN1 (7 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      RLN1 gene at Home site.
Version: 3.12.258 10 Dec 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4