Aliases for RLN1 Gene
External Ids for RLN1 Gene
Previous GeneCards Identifiers for RLN1 Gene
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. [provided by RefSeq, Jan 2013]
GeneCards Summary for RLN1 Gene
RLN1 (Relaxin 1) is a Protein Coding gene. Diseases associated with RLN1 include Preterm Premature Rupture Of The Membranes. Among its related pathways are CREB Pathway and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include hormone activity. An important paralog of this gene is RLN2.
UniProtKB/Swiss-Prot for RLN1 Gene
Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix.