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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RLN1 Gene

protein-coding   GIFtS: 53
GCID: GC09M005324

Relaxin 1

(Previous name: relaxin 1 (H1))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Relaxin 11 2     RLXH12
Prorelaxin H11 2     bA12D24.3.12
Relaxin 1 (H1)1     bA12D24.3.22
H12     Preprorelaxin H12
H1RLX2     

External Ids:    HGNC: 100261   Entrez Gene: 60132   Ensembl: ENSG000001070187   OMIM: 1797305   UniProtKB: P048083   

Export aliases for RLN1 gene to outside databases

Previous GC identifers: GC09M005488 GC09M005316


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RLN1 Gene:
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In
humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence
homology. The protein encoded by this gene is synthesized as a single-chain polypeptide but the active form
consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the
mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction.
It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and
releasing oxytocin and vasopressin. (provided by RefSeq, Jan 2013)

GeneCards Summary for RLN1 Gene: 
RLN1 (relaxin 1) is a protein-coding gene. Diseases associated with RLN1 include prostate adenocarcinoma, and germ cell cancer, and among its related super-pathways are CREB Pathway and Calcium Regulation in the Cardiac Cell. GO annotations related to this gene include hormone activity. An important paralog of this gene is RLN2.

UniProtKB/Swiss-Prot: REL1_HUMAN, P04808
Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many
mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic
ligaments and ripening of the cervix




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RLN1 gene promoter:
         Nkx3-1   RFX1   Nkx3-1 v4   LHX3b/Lhx3b   AML1a   Nkx3-1 v1   C/EBPalpha   Nkx3-1 v2   LHX3a/Lhx3a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRLN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RLN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RLN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p24.1   Ensembl cytogenetic band:  9p24.1   HGNC cytogenetic band: 9p24.1

RLN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RLN1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M005324:  view genomic region     (about GC identifiers)

Start:
5,334,969 bp from pter      End:
5,339,873 bp from pter
Size:
4,905 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: REL1_HUMAN, P04808 (See protein sequence)
Recommended Name: Prorelaxin H1 precursor  
Size: 185 amino acids; 21146 Da
Subunit: Heterodimer of a B chain and an A chain linked by two disulfide bonds
Subcellular location: Secreted
Secondary accessions: Q99936 Q9UQJ1
Alternative splicing: 2 isoforms:  P04808-1   P04808-2   

Explore the universe of human proteins at neXtProt for RLN1: NX_P04808

Explore proteomics data for RLN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04808

  • RLN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RLN1 Protein Expression
    REFSEQ proteins: NP_008842.1  
    ENSEMBL proteins: 
     ENSP00000223862   ENSP00000223858  

    Human Recombinant Protein Products for RLN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for RLN1 (Relaxin-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RLN1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RLN1
    GenScript Custom Purified and Recombinant Proteins Services for RLN1
    Novus Biologicals RLN1 Protein
    Novus Biologicals RLN1 Lysates
    Sino Biological Recombinant Protein for RLN1
    Sino Biological Cell Lysate for RLN1 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    RLN1 for ontologies           About GeneDecksing



    RLN1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RLN1 (Relaxin-1)
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    Novus Biologicals RLN1 Antibodies
    Abcam antibodies for RLN1
    Browse Antibodies at Cloud-Clone Corp. 
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    LSBio Antibodies in human, mouse, rat for RLN1 

    Assay Products for RLN1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR016179 Insulin-like
     IPR022352 Insulin_family
     IPR022421 Relaxin
     IPR022353 Insulin_CS

    Graphical View of Domain Structure for InterPro Entry P04808

    ProtoNet protein and cluster: P04808

    1 Blocks protein domain: IPB004825 Insulin/IGF/relaxin

    UniProtKB/Swiss-Prot: REL1_HUMAN, P04808
    Similarity: Belongs to the insulin family


    RLN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: REL1_HUMAN, P04808
    Function: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many
    mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic
    ligaments and ripening of the cervix

         Genatlas biochemistry entry for RLN1:
    relaxin 1 (H1)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
         
    RLN1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rln1):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     integument  mortality/aging  reproductive system  skeleton 

    RLN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rln1tm1Wint for RLN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RLN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RLN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RLN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RLN1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RLN1
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    SwitchGear 3'UTR luciferase reporter plasmidRLN1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: RLN1 (NM_006911)
    Sino Biological Human cDNA Clone for RLN1
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                         Customized lentivirus expression plasmids for stable overexpression of RLN1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RLN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CREB Pathway
    Activation of PKC through GPCR0.63
    2Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    3G-Beta Gamma Signaling
    Relaxin Pathway0.37
    4Androgen receptor signaling pathway
    Androgen receptor signaling pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RLN1
        Relaxin Pathway
    Activation of PKC through GPCR

    2 BioSystems Pathways for RLN1
        Myometrial Relaxation and Contraction Pathways
    Androgen receptor signaling pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RLN1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RLN1 (P048083 ENSP000002238624) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    RNF6Q9Y2523, ENSP000003421214I2D: score=1 STRING: ENSP00000342121
    RXFP1Q9HBX93, ENSP000003032484I2D: score=1 STRING: ENSP00000303248
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS6298628
    GO:0007565female pregnancy NAS6298628

    RLN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RLN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RLN1 (REL1)

    7 Novoseek inferred chemical compound relationships for RLN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preprorelaxin 87.4 1 1788398 (1)
    progestin 56.9 1 8040838 (1)
    c-peptide 36.3 6 1788398 (2), 8735594 (1), 9517397 (1)
    histamine 35.1 8 10067839 (2), 8739345 (2), 11312281 (1), 10604529 (1)
    nitric oxide 0 4 12237253 (1), 10604529 (1), 11003996 (1)
    calcium 0 1 17158203 (1)
    arginine 0 2 16467652 (1), 10604529 (1)

    Search CenterWatch for drugs/clinical trials and news about RLN1 / REL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RLN1 gene: 
    NM_006911.3  

    Unigene Cluster for RLN1:

    Relaxin 1
    Hs.368996  [show with all ESTs]
    Unigene Representative Sequence: NM_006911
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487557 ENST00000223862(uc003zjb.1) ENST00000223858
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RLN1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate RLN1
    SwitchGear 3'UTR luciferase reporter plasmidRLN1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RLN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RLN1
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    OriGene ORF clones in mouse, rat for RLN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RLN1 (NM_006911)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RLN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLN1
    Sirion Biotech Customized lentivirus for stable overexpression of RLN1 
                         Customized lentivirus expression plasmids for stable overexpression of RLN1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RLN1
    OriGene qSTAR qPCR primer pairs in human, mouse for RLN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RLN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RLN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RLN1

    Additional mRNA sequence: 

    AF057705.1 BC005956.1 X00949.1 

    1 DOTS entry:

    DT.91722059 

    15 AceView cDNA sequences:

    AA890637 X00949 AI089170 BC005956 NM_006911 BX283911 AI452485 BF681442 
    AF057705 BF222091 BG195391 AI363233 AA210817 AA508353 AI004059 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RLN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGAATTCA
    RLN1 Expression
    About this image


    See RLN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RLN1

    SOURCE GeneReport for Unigene cluster: Hs.368996

    UniProtKB/Swiss-Prot: REL1_HUMAN, P04808
    Tissue specificity: Prostate. Not expressed in placenta, decidua or ovary

        SABiosciences Custom PCR Arrays for RLN1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for RLN1 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rln11 , 5 relaxin 11, 5 63.75(n)1
    49.73(a)1
      19 (23.83 cM)5
    197731  NM_011272.21  NP_035402.21 
     293311705 


    ENSEMBL Gene Tree for RLN1 (if available)
    TreeFam Gene Tree for RLN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RLN1 gene
    RLN22  
    1 SIMAP similar gene for RLN1 using alignment to 1 protein entry:     REL1_HUMAN:
    RLN2

    RLN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/193 SNPs in RLN1 are shown (see all 193)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0119624
    ----see VAR_0119622 K M mis40--------
    rs1165513061,2
    F--5334483(+) ACAAGT/CGTTCA 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1869899801,2
    --5334510(+) TTGCTC/TACAGA 1 -- ds50010--------
    rs760944821,2
    F--5334518(+) AGAAAT/CAGTAA 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs1434687901,2
    --5334542(+) GAACAA/TAAGGT 1 -- ds50010--------
    rs1457715441,2
    --5334640(+) AAAAGG/TAACTT 1 -- ds50010--------
    rs776315001,2
    C,F--5334796(+) CAAACT/CGATGG 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1929088221,2
    --5334807(+) TTTGCA/CATGAG 1 -- ds50010--------
    rs47420811,2
    C,F,A,H--5334933(+) TGTAAC/GTGTTG 1 -- ut319Minor allele frequency- G:0.34NS EA WA NA CSA 644
    rs600351701,2
    C,F--5334946(+) AGGTAC/TTGTAT 1 -- ut312Minor allele frequency- T:0.04WA 120

    HapMap Linkage Disequilibrium report for RLN1 (5334969 - 5339873 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for RLN1 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2738159CNV Deletion23290073
    nsv818675CNV Loss17921354
    nsv466102CNV Loss19166990
    nsv831495CNV Loss17160897
    nsv466103CNV Loss19166990
    dgv8020n71CNV Loss21882294
    nsv892150CNV Loss21882294
    nsv466106CNV Loss19166990
    nsv824828CNV Loss20364138
    nsv466104CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RLN1
    DNA2.0 Custom Variant and Variant Library Synthesis for RLN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179730    OMIM disorders: --

    20/22 diseases for RLN1 (see all 22):    About MalaCards
    prostate adenocarcinoma    germ cell cancer    preterm premature rupture of the membranes    prostate cancer, progression of
    cryptorchidism    neuroendocrine tumor    endometriosis    prostatitis
    diabetes mellitus    type 1 diabetes    adenocarcinoma    prostate cancer
    hepatitis b    infertility    cerebritis    thyroiditis
    hypertension    cervicitis    hepatitis    endotheliitis


    RLN1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RLN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostatic adenocarcinoma 32.3 1 10750025 (1)
    heart failure congestive 0.0309 1 16467652 (1)
    heart failure 0 1 11641245 (1)

    Genetic Association Database (GAD): RLN1
    Human Genome Epidemiology (HuGE) Navigator: RLN1 (2 documents)

    Export disorders for RLN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RLN1 gene, integrated from 9 sources (see all 110):
    (articles sorted by number of sources associating them with RLN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of human relaxin genes: characterization of a novel alternatively-spliced human relaxin mRNA species. (PubMed id 8735594)1, 2, 9 Gunnersen J.M.... Tregear G.W. (1996)
    2. Analysis of the 5'-upstream regions of the human relaxin H1 and H2 genes and their chromosomal localization on chromosome 9p24.1 by radiation hybrid and breakpoint mapping. (PubMed id 10601981)1, 2, 9 Garibay-Tupas J.L....Bryant-Greenwood G.D. (1999)
    3. Polymorphisms in the promoter region of relaxin-2 and preterm birth: involvement of relaxin in the etiology of preterm birth. (PubMed id 20023247)1, 4, 9 Vogel I....Grove J. (2009)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones. (PubMed id 6548702)1, 2 Hudson P.... Niall H. (1984)
    7. Structure of a genomic clone encoding biologically active human relaxin. (PubMed id 6298628)1, 2 Hudson P.... Niall H. (1983)
    8. Isolation and analysis of the 3'-untranslated regions of the human relaxin H1 and H2 genes. (PubMed id 10750025)1, 9 Garibay-Tupas J.L....Bryant-Greenwood G.D. (2000)
    9. Adenovirus-mediated expression of human prorelaxin promotes the invasive potential of canine mammary cancer cells. (PubMed id 12865351)1, 9 Silvertown J.D....Summerlee A.J. (2003)
    10. Characterization of human relaxin gene regulation in the relaxin-expressing human prostate adenocarcinoma cell line LNCaP.FGC. (PubMed id 8800640)1, 9 Gunnersen J.M....Crawford R.J. (1995)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6013 HGNC: 10026 AceView: RLN1 Ensembl:ENSG00000107018 euGenes: HUgn6013
    ECgene: RLN1 H-InvDB: RLN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for RLN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RLN1 gene:
    Search GeneIP for patents involving RLN1

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