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RLIM Gene

protein-coding   GIFtS: 50
GCID: GC0XM073803

Ring Finger Protein, LIM Domain Interacting

(Previous name: ring finger protein 12)
(Previous symbol: RNF12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ring Finger Protein, LIM Domain Interacting1 2     LIM Domain Interacting Ring Finger Protein1
RNF121 2 3 5     NY-REN-432
RING Finger Protein 121 2 3     E3 Ubiquitin-Protein Ligase RLIM2
Ring Zinc Finger Protein NY-REN-43antigen1 2     E3 Ubiquitin-Protein Ligase RNF122
Renal Carcinoma Antigen NY-REN-432 3     Ring Zinc Finger LIM Domain Binding Protein2
R-LIM2 3     EC 6.3.2.-3
LIM Domain-Interacting RING Finger Protein2 3     EC 6.3.28
RING Finger LIM Domain-Binding Protein2 3     

External Ids:    HGNC: 134291   Entrez Gene: 511322   Ensembl: ENSG000001312637   OMIM: 3003795   UniProtKB: Q9NVW23   

Export aliases for RLIM gene to outside databases

Previous GC identifers: GC0XM073726 GC0XM067438


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RLIM Gene:
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein
ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This
protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively
spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Feb 2009)

GeneCards Summary for RLIM Gene:
RLIM (ring finger protein, LIM domain interacting) is a protein-coding gene. Diseases associated with RLIM include smallpox, and pertussis. GO annotations related to this gene include ubiquitin-protein ligase activity and transcription corepressor activity. An important paralog of this gene is RNF6.

UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2
Function: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by
mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the
recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors
LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such
as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and
degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X
chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related
dosage differences of X-encoded genes in somatic cells of female placental mammals

Gene Wiki entry for RLIM (RNF12) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the RLIM gene promoter:
         HOXA9   Bach1   LHX3b/Lhx3b   POU3F1   Meis-1b   FOXL1   Max   LHX3a/Lhx3a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRLIM promoter sequence
   Search Chromatin IP Primers for RLIM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RLIM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13-q21   Ensembl cytogenetic band:  Xq13.2   HGNC cytogenetic band: Xq13-q21

RLIM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RLIM gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM073803:  view genomic region     (about GC identifiers)

Start:
73,802,811 bp from pter      End:
73,834,461 bp from pter
Size:
31,651 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RLIM  
Size: 624 amino acids; 68549 Da
Subunit: Interacts with LIM/homeobox factors such as LHX3. Interacts with LDB1, LDB2 and SIN3A (By similarity).
Interacts with LIMK1 (By similarity). Interacts (via N-terminus) with TERF1. Interacts (via C-terminus) with ESR1
Miscellaneous: Acts as a positive coregulator of ESR1-mediated transcription in breast cancer cells
Sequence caution: Sequence=AAD42875.1; Type=Frameshift; Positions=134, 142;
Secondary accessions: D3DTE0 Q96D38 Q9Y598

Explore the universe of human proteins at neXtProt for RLIM: NX_Q9NVW2

Explore proteomics data for RLIM at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys550, Lys568, Lys582
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RLIM (Q9NVW2) (see all 10)
     EGSSRTR  KLRKLPCSHE  RGQRRARSRSPD  SLAQFFLLNEDD 


    See RLIM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_057204.2  NP_899196.1  

    ENSEMBL proteins: 
     ENSP00000328059   ENSP00000253571  

    RLIM Human Recombinant Protein Products:

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    Novus Biologicals RLIM Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9NVW2

    ProtoNet protein and cluster: Q9NVW2

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2
    Similarity: Belongs to the RNF12 family
    Similarity: Contains 1 RING-type zinc finger


    RLIM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF12_HUMAN, Q9NVW2
    Function: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by
    mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the
    recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors
    LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such
    as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and
    degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X
    chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related
    dosage differences of X-encoded genes in somatic cells of female placental mammals

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity NAS11013082
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RLIM for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rlim):
     cellular  embryogenesis  mortality/aging  normal  reproductive system 

    RLIM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rlimtm1.2Inba for RLIM

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RLIM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RLIM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RLIM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RLIM

    miRNA
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    miRTarBase miRNAs that target RLIM:
    hsa-mir-15b-5p (MIRT046403), hsa-mir-10a-5p (MIRT047752), hsa-mir-186-5p (MIRT044990), hsa-mir-100-5p (MIRT048396)

    Block miRNA regulation of human, mouse, rat RLIM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RLIM (see all 193):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-3170 hsa-miR-200b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidRLIM 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RLIM
    Predesigned siRNA for gene silencing in human, mouse, rat RLIM

    Gene Editing
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    OriGene ORF clones in mouse, rat for RLIM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RLIM (NM_183353)
    Sino Biological Human cDNA Clone for RLIM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RLIM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLIM

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RLIM
    Browse ESI BIO Cell Lines and PureStem Progenitors for RLIM 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLIM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RNF12_HUMAN, Q9NVW2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA--
    GO:0017053transcriptional repressor complex NAS11013082

    RLIM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RLIM
    Interactions:

        GeneGlobe Interaction Network for RLIM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RLIM (Q9NVW22, 3 ENSP000002535714) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB2O436792, 3, ENSP000003067724MINT-14725 MINT-17380 I2D: score=2 STRING: ENSP00000306772
    LDB1Q86U702, 3, ENSP000003924664MINT-13731 I2D: score=3 STRING: ENSP00000392466
    LMO2P257912, 3, ENSP000002578184MINT-17113 I2D: score=2 STRING: ENSP00000257818
    LHX3Q9UBR43, ENSP000003608114I2D: score=2 STRING: ENSP00000360811
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006511ubiquitin-dependent protein catabolic process ISS--
    GO:0016567protein ubiquitination ISS--
    GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity IEA--

    RLIM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RLIM (RNF12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RLIM gene (2 alternative transcripts): 
    NM_016120.3  NM_183353.2  

    Unigene Cluster for RLIM:

    Ring finger protein, LIM domain interacting
    Hs.653288  [show with all ESTs]
    Unigene Representative Sequence: NM_183353
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332687(uc004ebu.3 uc004ebw.3) ENST00000349225
    miRNA
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    Block miRNA regulation of human, mouse, rat RLIM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RLIM (see all 193):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-3170 hsa-miR-200b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidRLIM 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RLIM
    Predesigned siRNA for gene silencing in human, mouse, rat RLIM
    Clone
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    OriGene ORF clones in mouse, rat for RLIM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RLIM (NM_183353)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RLIM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLIM
    Primer
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    OriGene qPCR primer pairs and template standards for RLIM
    OriGene qSTAR qPCR primer pairs in human, mouse for RLIM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RLIM
      QuantiTect SYBR Green Assays in human, mouse, rat RLIM
      QuantiFast Probe-based Assays in human, mouse, rat RLIM

    Additional mRNA sequence: 

    AF086467.1 AF155109.1 AK001334.1 AK098789.1 AK123088.1 AK124877.1 AK127880.1 AK314760.1 
    BC013357.2 BX648613.1 

    Selected DOTS entries (see all 25):

    DT.410275  DT.300473  DT.100642596  DT.95267608  DT.92470838  DT.91801712  DT.100700590  DT.100700601 
    DT.100043224  DT.100700595  DT.92470903  DT.121319026  DT.95267607  DT.102836544  DT.92470896  DT.97869208 
    DT.86839552  DT.100040311  DT.100700578  DT.100852698  DT.101963232  DT.121466365  DT.40122970  DT.91815156 

    Selected AceView cDNA sequences (see all 238):

    AA910581 AI343614 AK123088 AA683609 AI278036 AW418948 BQ446972 BU167666 
    BU521294 BE614499 BX646530 BQ005658 AA733007 AI078733 NM_183353 AA598809 
    AA885092 BC013357 AI696579 AK124877 AI090781 BM977821 BM683073 AI537786 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RLIM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RLIM Expression
    About this image

    RLIM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RLIM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653288

    UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2
    Tissue specificity: Expressed in many tissues

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    QuantiFast Probe-based Assays in human, mouse, rat RLIM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLIM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RLIM gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rlim1 , 5 ring finger protein, LIM domain interacting1, 5 86.56(n)1
    88.48(a)1
      X (46.42 cM)5
    198201  NM_011276.31  NP_035406.31 
     1039571635 
    chicken
    (Gallus gallus)
    Aves RLIM1 ring finger protein, LIM domain interacting 79.55(n)
    79.09(a)
      395630  NM_204828.1  NP_990159.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    72(a)
    many ↔ many
    GL343813.1(108083-111612)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.294502 Xenopus laevis XRnf12C mRNA for XRnf12C, complete cds 78.35(n)    AB114041.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5624871 E3 ubiquitin-protein ligase RNF12-A-like 76.4(n)
    86.73(a)
      562487  XM_680935.6  XP_686027.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta mura6
    murashka
    11(a)
    1 → many
    3R(5363876-5377528)


    ENSEMBL Gene Tree for RLIM (if available)
    TreeFam Gene Tree for RLIM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RLIM gene
    RNF62  RNF382  RNF442  
    7 SIMAP similar genes for RLIM using alignment to 2 protein entries:     RNF12_HUMAN (see all proteins):
    PABPC1    PABPC3    PABPC4    UBR5    PABPC1L    RNF6
    DKFZp686P0776

    RLIM for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RLIM
    PGOHUM00000247113 PGOHUM00000244148


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RLIM (see all 396)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59812871,2
    C,F,H--73810000(+) CTGCAA/GTTCAT 2 -- ut3111Minor allele frequency- G:0.03NS EA NA WA 1360
    rs1822489161,2
    C--73810449(+) GCACCC/TGGCAG 2 -- ds50010--------
    rs1853876801,2
    --73810495(+) CTAGTC/TATTTC 2 -- ds50010--------
    rs577162741,2
    C,F--73810537(+) GCACAT/CGTAAT 2 -- ds50011Minor allele frequency- C:0.00WA 2
    rs1921621121,2
    --73810817(+) TACTAA/TTTTTT 2 -- ds50010--------
    rs2000151061,2
    --73810828(+) TTGTG-/TTTT  
            
    TTGTT
    2 -- ds50010--------
    rs1425000801,2
    --73810900(+) ACATAA/CGGTTC 2 -- ds50010--------
    rs2011225541,2
    C--73810942(+) CCATA-/TTTTAA 2 -- ut310--------
    rs2004428651,2
    C--73810984(+) GAAGCA/CCAAGT 2 -- ut310--------
    rs2010845891,2
    C--73811004(+) TGGTCC/TCTGAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RLIM (73802811 - 73834461 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RLIM:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2740232CNV Deletion23290073
    nsv521472CNV Gain19592680

    Locus Specific Mutation Databases (LSDB): RLIM

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300379    OMIM disorders: --

    7 diseases for RLIM:    
    About MalaCards
    smallpox    pertussis    kaposi's sarcoma    renal cell carcinoma
    sarcoma    breast cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for RLIM:
    Pertussis

    RLIM for disorders           About GeneDecksing


    Export disorders for RLIM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RLIM gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with RLIM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2, 3 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    2. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. (PubMed id 19117995)1, 2, 9 Johnsen S.A.... Bach I. (Cancer Res. 2009)
    3. Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain transcription factors. (PubMed id 11013082)1, 2, 9 Ostendorff H.P.... Bach I. (Genomics 2000)
    4. Ubiquitin ligase RLIM modulates telomere length homeostasis through a proteolysis of TRF1. (PubMed id 19164295)1, 2 Her Y.R. and Chung I.K. (J. Biol. Chem. 2009)
    5. RNF12 is an X-encoded dose-dependent activator of X chromosome inactivation. (PubMed id 19945382)1, 2 Jonkers I.... Gribnau J. (Cell 2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. (PubMed id 11882901)1, 9 Ostendorff H.P....Bach I. (Nature 2002)
    8. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. (PubMed id 10431247)1, 9 Bach I....Rosenfeld M.G. (Nat. Genet. 1999)
    9. p53 Represses transcription of RING finger LIM domain-binding protein RLIM through Sp1. (PubMed id 23650532)1 Kong X....Yu L. (PLoS ONE 2013)
    10. RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation. (PubMed id 22596162)1 Gontan C....Gribnau J. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51132 HGNC: 13429 AceView: RNF12andPABPCP3 Ensembl:ENSG00000131263 euGenes: HUgn51132
    ECgene: RLIM H-InvDB: RLIM

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RLIM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RLIM gene:
    Search GeneIP for patents involving RLIM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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