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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RLIM Gene

protein-coding   GIFtS: 49
GCID: GC0XM073803

Ring Finger Protein, LIM Domain Interacting

(Previous name: ring finger protein 12)
(Previous symbol: RNF12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ring Finger Protein, LIM Domain Interacting1 2     LIM Domain Interacting Ring Finger Protein1
RNF121 2 3 5     NY-REN-432
RING Finger Protein 121 2 3     E3 Ubiquitin-Protein Ligase RLIM2
Ring Zinc Finger Protein NY-REN-43antigen1 2     E3 Ubiquitin-Protein Ligase RNF122
Renal Carcinoma Antigen NY-REN-432 3     Ring Zinc Finger LIM Domain Binding Protein2
R-LIM2 3     EC 6.3.2.-3
LIM Domain-Interacting RING Finger Protein2 3     EC 6.3.28
RING Finger LIM Domain-Binding Protein2 3     

External Ids:    HGNC: 134291   Entrez Gene: 511322   Ensembl: ENSG000001312637   OMIM: 3003795   UniProtKB: Q9NVW23   

Export aliases for RLIM gene to outside databases

Previous GC identifers: GC0XM073726 GC0XM067438


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RLIM Gene:
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein
ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This
protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively
spliced variants, encoding the same protein, have been identified. (provided by RefSeq, Feb 2009)

GeneCards Summary for RLIM Gene: 
RLIM (ring finger protein, LIM domain interacting) is a protein-coding gene. Diseases associated with RLIM include smallpox, and pertussis. GO annotations related to this gene include ubiquitin-protein ligase activity and transcription corepressor activity. An important paralog of this gene is RNF6.

UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2
Function: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by
mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the
recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors
LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such
as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and
degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X
chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related
dosage differences of X-encoded genes in somatic cells of female placental mammals

Gene Wiki entry for RLIM (RNF12) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011669.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RLIM gene promoter:
         HOXA9   Bach1   LHX3b/Lhx3b   POU3F1   Meis-1b   FOXL1   Max   LHX3a/Lhx3a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRLIM promoter sequence
   Search SABiosciences Chromatin IP Primers for RLIM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RLIM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13-q21   Ensembl cytogenetic band:  Xq13.2   HGNC cytogenetic band: Xq13-q21

RLIM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RLIM gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM073803:  view genomic region     (about GC identifiers)

Start:
73,802,811 bp from pter      End:
73,834,461 bp from pter
Size:
31,651 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase RLIM  
Size: 624 amino acids; 68549 Da
Subunit: Interacts with LIM/homeobox factors such as LHX3. Interacts with LDB1, LDB2 and SIN3A (By similarity).
Interacts with LIMK1 (By similarity). Interacts (via N-terminus) with TERF1. Interacts (via C-terminus) with ESR1
Subcellular location: Nucleus
Miscellaneous: Acts as a positive coregulator of ESR1-mediated transcription in breast cancer cells
Sequence caution: Sequence=AAD42875.1; Type=Frameshift; Positions=134, 142;
Secondary accessions: D3DTE0 Q96D38 Q9Y598

Explore the universe of human proteins at neXtProt for RLIM: NX_Q9NVW2

Explore proteomics data for RLIM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVW2

  • 4/10 DME Specific Peptides for RLIM (Q9NVW2) (see all 10)
     EGSSRTR  KLRKLPCSHE  RGQRRARSRSPD  SLAQFFLLNEDD 

    RLIM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RLIM Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_057204.2  NP_899196.1  

    ENSEMBL proteins: 
     ENSP00000328059   ENSP00000253571  

    Human Recombinant Protein Products for RLIM: 
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    Novus Biologicals RLIM Proteins
    Novus Biologicals RLIM Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IDA--
    GO:0017053transcriptional repressor complex NAS11013082

    RLIM for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9NVW2

    ProtoNet protein and cluster: Q9NVW2

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2
    Similarity: Belongs to the RNF12 family
    Similarity: Contains 1 RING-type zinc finger


    RLIM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RNF12_HUMAN, Q9NVW2
    Function: E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by
    mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the
    recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors
    LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such
    as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and
    degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X
    chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related
    dosage differences of X-encoded genes in somatic cells of female placental mammals

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity NAS11013082
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    RLIM for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rlim):
     cellular  embryogenesis  mortality/aging  normal  reproductive system 

    RLIM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rlimtm1.2Inba for RLIM

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RLIM 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RLIM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RLIM 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RLIM 

    miRNA
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    8/193 QIAGEN miScript miRNA Assays for microRNAs that regulate RLIM (see all 193):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-3170 hsa-miR-200b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidRLIM 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of RLIM 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLIM


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RLIM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for RLIM (Q9NVW22, 3 ENSP000002535714) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LDB2O436792, 3, ENSP000003067724MINT-14725 MINT-17380 I2D: score=2 STRING: ENSP00000306772
    LDB1Q86U702, 3, ENSP000003924664MINT-13731 I2D: score=3 STRING: ENSP00000392466
    LMO2P257912, 3, ENSP000002578184MINT-17113 I2D: score=2 STRING: ENSP00000257818
    LHX3Q9UBR43, ENSP000003608114I2D: score=2 STRING: ENSP00000360811
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006511ubiquitin-dependent protein catabolic process ISS--
    GO:0016567protein ubiquitination ISS--
    GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity IEA--

    RLIM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RLIM (RNF12)

    Search CenterWatch for drugs/clinical trials and news about RLIM / RNF12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RLIM gene (2 alternative transcripts): 
    NM_016120.3  NM_183353.2  

    Unigene Cluster for RLIM:

    Ring finger protein, LIM domain interacting
    Hs.653288  [show with all ESTs]
    Unigene Representative Sequence: NM_183353
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332687(uc004ebu.3 uc004ebw.3) ENST00000349225
    miRNA
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    8/193 QIAGEN miScript miRNA Assays for microRNAs that regulate RLIM (see all 193):
    hsa-miR-140-5p hsa-miR-106a hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-3170 hsa-miR-200b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidRLIM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    OriGene ORF clones in mouse, rat for RLIM
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RLIM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLIM
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RLIM

    Additional mRNA sequence: 

    AF086467.1 AF155109.1 AK001334.1 AK098789.1 AK123088.1 AK124877.1 AK127880.1 AK314760.1 
    BC013357.2 BX648613.1 

    24/25 DOTS entries (see all 25):

    DT.410275  DT.300473  DT.100642596  DT.95267608  DT.92470838  DT.91801712  DT.100700590  DT.100700601 
    DT.100043224  DT.100700595  DT.92470903  DT.121319026  DT.95267607  DT.102836544  DT.92470896  DT.97869208 
    DT.86839552  DT.100040311  DT.100700578  DT.100852698  DT.101963232  DT.121466365  DT.40122970  DT.91815156 

    24/238 AceView cDNA sequences (see all 238):

    AA405476 BI962780 BM769057 AK124877 AK123088 BU146494 AI590361 AI955477 
    BU167063 BQ446972 BM715663 BQ006731 AA670260 CD106727 AI261525 AA569127 
    AI696579 AL712605 BM850296 AA516103 AI343614 AA733007 BM977821 BX116090 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RLIM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RLIM Expression
    About this image


    See RLIM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RLIM

    SOURCE GeneReport for Unigene cluster: Hs.653288

    UniProtKB/Swiss-Prot: RNF12_HUMAN, Q9NVW2
    Tissue specificity: Expressed in many tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RLIM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RLIM gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rlim1 , 5 ring finger protein, LIM domain interacting1, 5 87(n)1
    89.17(a)1
      X (46.42 cM)5
    198201  NM_011276.31  NP_035406.31 
     1039571635 
    chicken
    (Gallus gallus)
    Aves RLIM1 ring finger protein, LIM domain interacting 79.32(n)
    80.85(a)
      395630  NM_204828.1  NP_990159.1 
    lizard
    (Anolis carolinensis)
    Reptilia RLIM6
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343813.1(108083-111612)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.294502 Xenopus laevis XRnf12C mRNA for XRnf12C, complete cds 78.35(n)    AB114041.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5624871 e3 ubiquitin-protein ligase RNF12-A-like 60.71(n)
    61.94(a)
      562487  XM_680935.5  XP_686027.3 


    ENSEMBL Gene Tree for RLIM (if available)
    TreeFam Gene Tree for RLIM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RLIM gene
    RNF62  RNF382  RNF442  
    7 SIMAP similar genes for RLIM using alignment to 2 protein entries:     RNF12_HUMAN (see all proteins):
    PABPC1    PABPC3    PABPC4    UBR5    PABPC1L    RNF6
    DKFZp686P0776

    RLIM for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RLIM
    PGOHUM00000247113 PGOHUM00000244148


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/396 SNPs in RLIM are shown (see all 396)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs59812871,2
    C,F,H--73810000(+) CTGCAA/GTTCAT 2 -- ut3111Minor allele frequency- G:0.03NS EA NA WA 1360
    rs1822489161,2
    C--73810449(+) GCACCC/TGGCAG 2 -- ds50010--------
    rs1853876801,2
    --73810495(+) CTAGTC/TATTTC 2 -- ds50010--------
    rs577162741,2
    C,F--73810537(+) GCACAT/CGTAAT 2 -- ds50011Minor allele frequency- C:0.00WA 2
    rs1921621121,2
    --73810817(+) TACTAA/TTTTTT 2 -- ds50010--------
    rs2000151061,2
    --73810828(+) TTGTG-/TTTT  
            
    TTGTT
    2 -- ds50010--------
    rs1425000801,2
    --73810900(+) ACATAA/CGGTTC 2 -- ds50010--------
    rs2011225541,2
    C--73810942(+) CCATA-/TTTTAA 2 -- ut310--------
    rs2004428651,2
    C--73810984(+) GAAGCA/CCAAGT 2 -- ut310--------
    rs2010845891,2
    C--73811004(+) TGGTCC/TCTGAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for RLIM (73802811 - 73834461 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RLIM:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740232CNV Deletion23290073
    nsv521472CNV Gain19592680


    Locus Specific Mutation Databases (LSDB): RLIM
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300379    OMIM disorders: --

    7 diseases for RLIM:    About MalaCards
    smallpox    pertussis    renal cell carcinoma    kaposi's sarcoma
    sarcoma    breast cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for RLIM:
    Pertussis

    RLIM for disorders           About GeneDecksing


    Export disorders for RLIM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RLIM gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with RLIM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2, 3 Scanlan M.J....Old L.J. (1999)
    2. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. (PubMed id 19117995)1, 2, 9 Johnsen S.A.... Bach I. (2009)
    3. Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain transcription factors. (PubMed id 11013082)1, 2, 9 Ostendorff H.P.... Bach I. (2000)
    4. Ubiquitin ligase RLIM modulates telomere length homeostasis through a proteolysis of TRF1. (PubMed id 19164295)1, 2 Her Y.R. and Chung I.K. (2009)
    5. RNF12 is an X-encoded dose-dependent activator of X chromosome inactivation. (PubMed id 19945382)1, 2 Jonkers I.... Gribnau J. (2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. (PubMed id 11882901)1, 9 Ostendorff H.P....Bach I. (2002)
    8. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. (PubMed id 10431247)1, 9 Bach I....Rosenfeld M.G. (1999)
    9. RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation. (PubMed id 22596162)1 Gontan C....Gribnau J. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51132 HGNC: 13429 AceView: RNF12andPABPCP3 Ensembl:ENSG00000131263 euGenes: HUgn51132
    ECgene: RLIM H-InvDB: RLIM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RLIM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RLIM gene:
    Search GeneIP for patents involving RLIM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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