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Aliases for RLF Gene

Aliases for RLF Gene

  • Rearranged L-Myc Fusion 2 3
  • Rearranged L-Myc Fusion Gene Protein 3 4
  • Rearranged L-Myc Fusion Sequence 2 3
  • Zn-15-Related Protein 3 4
  • Zn-15 Related 3
  • ZNF292L 3
  • ZN-15L 3

External Ids for RLF Gene

Previous GeneCards Identifiers for RLF Gene

  • GC01P040661
  • GC01P039630
  • GC01P040090
  • GC01P040040
  • GC01P040296
  • GC01P040399
  • GC01P040627
  • GC01P038745

Summaries for RLF Gene

GeneCards Summary for RLF Gene

RLF (Rearranged L-Myc Fusion) is a Protein Coding gene. An important paralog of this gene is ZNF654.

UniProtKB/Swiss-Prot for RLF Gene

  • May be involved in transcriptional regulation

Gene Wiki entry for RLF Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RLF Gene

Genomics for RLF Gene

Regulatory Elements for RLF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RLF Gene

Chromosome:
1
Start:
40,161,369 bp from pter
End:
40,240,921 bp from pter
Size:
79,553 bases
Orientation:
Plus strand

Genomic View for RLF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RLF Gene

Proteins for RLF Gene

  • Protein details for RLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13129-RLF_HUMAN
    Recommended name:
    Zinc finger protein Rlf
    Protein Accession:
    Q13129
    Secondary Accessions:
    • Q14CQ1
    • Q9NU60

    Protein attributes for RLF Gene

    Size:
    1914 amino acids
    Molecular mass:
    217953 Da
    Quaternary structure:
    • Interacts with RIT1 and RIT2.
    Miscellaneous:
    • In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc

neXtProt entry for RLF Gene

Proteomics data for RLF Gene at MOPED

Post-translational modifications for RLF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RLF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RLF Gene

Domains & Families for RLF Gene

Gene Families for RLF Gene

Protein Domains for RLF Gene

Suggested Antigen Peptide Sequences for RLF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13129

UniProtKB/Swiss-Prot:

RLF_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with RLF: view

Function for RLF Gene

Molecular function for RLF Gene

GENATLAS Biochemistry:
rearranged l-myc fusion gene,in small cell lung carcinoma
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation

Gene Ontology (GO) - Molecular Function for RLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 8545128
GO:0005515 protein binding IPI 10545207
GO:0008270 zinc ion binding TAS 8545128
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with RLF: view
genes like me logo Genes that share phenotypes with RLF: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RLF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RLF Gene

Localization for RLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RLF Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RLF Gene COMPARTMENTS Subcellular localization image for RLF gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for RLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 8545128
genes like me logo Genes that share ontologies with RLF: view

Pathways & Interactions for RLF Gene

SuperPathways for RLF Gene

No Data Available

Gene Ontology (GO) - Biological Process for RLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8545128
GO:0015074 DNA integration IDA 1851085
GO:0045893 positive regulation of transcription, DNA-templated ISS 8545128
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS 8545128
genes like me logo Genes that share ontologies with RLF: view

No data available for Pathways by source and SIGNOR curated interactions for RLF Gene

Drugs & Compounds for RLF Gene

No Compound Related Data Available

Transcripts for RLF Gene

mRNA/cDNA for RLF Gene

Unigene Clusters for RLF Gene

Rearranged L-myc fusion:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RLF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RLF Gene

No ASD Table

Relevant External Links for RLF Gene

GeneLoc Exon Structure for
RLF
ECgene alternative splicing isoforms for
RLF

Expression for RLF Gene

mRNA expression in normal human tissues for RLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RLF Gene

This gene is overexpressed in Breast (41.0), Platelet (12.7), and Gallbladder (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RLF Gene



SOURCE GeneReport for Unigene cluster for RLF Gene Hs.205627

mRNA Expression by UniProt/SwissProt for RLF Gene

Q13129-RLF_HUMAN
Tissue specificity: Widely expressed in fetal and adult tissues
genes like me logo Genes that share expression patterns with RLF: view

Protein tissue co-expression partners for RLF Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RLF Gene

Orthologs for RLF Gene

This gene was present in the common ancestor of chordates.

Orthologs for RLF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RLF 35
  • 92.76 (n)
  • 94.19 (a)
RLF 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RLF 35
  • 94.16 (n)
  • 95.54 (a)
RLF 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rlf 35
  • 87.43 (n)
  • 89.1 (a)
Rlf 16
Rlf 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RLF 35
  • 99.6 (n)
  • 99.79 (a)
RLF 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rlf 35
  • 87.52 (n)
  • 89.76 (a)
oppossum
(Monodelphis domestica)
Mammalia RLF 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RLF 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves RLF 35
  • 69.52 (n)
  • 66.61 (a)
RLF 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RLF 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rlf 35
  • 59.36 (n)
  • 51.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30567 35
zebrafish
(Danio rerio)
Actinopterygii rlf 35
  • 51.9 (n)
  • 43.65 (a)
rlf 36
  • 32 (a)
OneToOne
Species with no ortholog for RLF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RLF Gene

ENSEMBL:
Gene Tree for RLF (if available)
TreeFam:
Gene Tree for RLF (if available)

Paralogs for RLF Gene

Paralogs for RLF Gene

(1) SIMAP similar genes for RLF Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RLF Gene

genes like me logo Genes that share paralogs with RLF: view

Variants for RLF Gene

Sequence variations from dbSNP and Humsavar for RLF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12492 -- 40,183,674(-) GGATT(C/T)GAACT intron-variant
rs14404 -- 40,183,505(-) TTCTT(C/G)CCGAG intron-variant
rs954187 -- 40,213,183(-) CTTTA(A/G)GAGAT intron-variant
rs74502932 -- 40,189,807(+) ACAAC(A/C)AAAAA intron-variant
rs74503183 -- 40,173,531(+) TTTTT(A/T)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RLF Gene

Variant ID Type Subtype PubMed ID
dgv49e1 CNV Complex 17122850
nsv829660 CNV Gain+Loss 17160897
nsv521874 CNV Loss 19592680
esv2673542 CNV Deletion 23128226
esv2747352 CNV Deletion 23290073

Variation tolerance for RLF Gene

Residual Variation Intolerance Score: 22.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RLF Gene

HapMap Linkage Disequilibrium report
RLF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RLF Gene

Disorders for RLF Gene

Relevant External Links for RLF

Genetic Association Database (GAD)
RLF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RLF
genes like me logo Genes that share disorders with RLF: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RLF Gene

Publications for RLF Gene

  1. Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer. (PMID: 1649386) MAokelAo T.P. … Alitalo K. (Mol. Cell. Biol. 1991) 2 23 67
  2. The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization. (PMID: 10760592) Sood R. … Bonner T.I. (Biochim. Biophys. Acta 2000) 23 67
  3. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines. (PMID: 9747881) Kim J.-O. … Kelley M.J. (Oncogene 1998) 23 67
  4. Mechanically stretched chromosomes as targets for high-resolution FISH mapping. (PMID: 8717051) Laan M. … Palotie A. (Genome Res. 1995) 23 67
  5. The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. (PMID: 8545128) Makela T.P. … Alitalo K. (Oncogene 1995) 23 67

Products for RLF Gene

Sources for RLF Gene

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