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Aliases for RLF Gene

Aliases for RLF Gene

  • Rearranged L-Myc Fusion 2 3 5
  • Rearranged L-Myc Fusion Gene Protein 3 4
  • Rearranged L-Myc Fusion Sequence 2 3
  • Zn-15-Related Protein 3 4
  • Zn-15 Related 3
  • ZNF292L 3
  • ZN-15L 3

External Ids for RLF Gene

Previous GeneCards Identifiers for RLF Gene

  • GC01P040661
  • GC01P039630
  • GC01P040090
  • GC01P040040
  • GC01P040296
  • GC01P040399
  • GC01P040627
  • GC01P038745

Summaries for RLF Gene

GeneCards Summary for RLF Gene

RLF (Rearranged L-Myc Fusion) is a Protein Coding gene. An important paralog of this gene is ZNF654.

UniProtKB/Swiss-Prot for RLF Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for RLF Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RLF Gene

Genomics for RLF Gene

Regulatory Elements for RLF Gene

Enhancers for RLF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RLF on UCSC Golden Path with GeneCards custom track

Promoters for RLF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RLF on UCSC Golden Path with GeneCards custom track

Genomic Location for RLF Gene

40,161,369 bp from pter
40,240,921 bp from pter
79,553 bases
Plus strand

Genomic View for RLF Gene

Genes around RLF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RLF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RLF Gene

Proteins for RLF Gene

  • Protein details for RLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein Rlf
    Protein Accession:
    Secondary Accessions:
    • Q14CQ1
    • Q9NU60

    Protein attributes for RLF Gene

    1914 amino acids
    Molecular mass:
    217953 Da
    Quaternary structure:
    • Interacts with RIT1 and RIT2.
    • In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc.

neXtProt entry for RLF Gene

Proteomics data for RLF Gene at MOPED

Post-translational modifications for RLF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RLF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RLF Gene

Domains & Families for RLF Gene

Gene Families for RLF Gene

Protein Domains for RLF Gene

Suggested Antigen Peptide Sequences for RLF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Contains 14 C2H2-type zinc fingers.
genes like me logo Genes that share domains with RLF: view

Function for RLF Gene

Molecular function for RLF Gene

GENATLAS Biochemistry:
rearranged l-myc fusion gene,in small cell lung carcinoma
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
genes like me logo Genes that share phenotypes with RLF: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RLF Gene

Localization for RLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RLF Gene


Subcellular locations from

Jensen Localization Image for RLF Gene COMPARTMENTS Subcellular localization image for RLF gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for RLF Gene

Pathways & Interactions for RLF Gene

SuperPathways for RLF Gene

No Data Available

Gene Ontology (GO) - Biological Process for RLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015074 DNA integration IDA 1851085
GO:0045893 positive regulation of transcription, DNA-templated ISS 8545128
GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS 8545128
GO:0051276 chromosome organization NAS 8545128
genes like me logo Genes that share ontologies with RLF: view

No data available for Pathways by source and SIGNOR curated interactions for RLF Gene

Drugs & Compounds for RLF Gene

No Compound Related Data Available

Transcripts for RLF Gene

mRNA/cDNA for RLF Gene

Unigene Clusters for RLF Gene

Rearranged L-myc fusion:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RLF Gene

No ASD Table

Relevant External Links for RLF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RLF Gene

mRNA expression in normal human tissues for RLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RLF Gene

This gene is overexpressed in Breast (41.0), Platelet (12.7), and Gallbladder (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RLF Gene

SOURCE GeneReport for Unigene cluster for RLF Gene Hs.205627

mRNA Expression by UniProt/SwissProt for RLF Gene

Tissue specificity: Widely expressed in fetal and adult tissues.
genes like me logo Genes that share expression patterns with RLF: view

Protein tissue co-expression partners for RLF Gene

Primer Products

No data available for mRNA differential expression in normal tissues for RLF Gene

Orthologs for RLF Gene

This gene was present in the common ancestor of chordates.

Orthologs for RLF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RLF 35
  • 92.76 (n)
  • 94.19 (a)
RLF 36
  • 94 (a)
(Canis familiaris)
Mammalia RLF 35
  • 94.16 (n)
  • 95.54 (a)
RLF 36
  • 95 (a)
(Mus musculus)
Mammalia Rlf 35
  • 87.43 (n)
  • 89.1 (a)
Rlf 16
Rlf 36
  • 87 (a)
(Pan troglodytes)
Mammalia RLF 35
  • 99.6 (n)
  • 99.79 (a)
RLF 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Rlf 35
  • 87.52 (n)
  • 89.76 (a)
(Monodelphis domestica)
Mammalia RLF 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RLF 36
  • 65 (a)
(Gallus gallus)
Aves RLF 35
  • 69.52 (n)
  • 66.61 (a)
RLF 36
  • 61 (a)
(Anolis carolinensis)
Reptilia RLF 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rlf 35
  • 59.36 (n)
  • 51.26 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30567 35
(Danio rerio)
Actinopterygii rlf 35
  • 51.9 (n)
  • 43.65 (a)
rlf 36
  • 32 (a)
Species with no ortholog for RLF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RLF Gene

Gene Tree for RLF (if available)
Gene Tree for RLF (if available)

Paralogs for RLF Gene

Paralogs for RLF Gene

(1) SIMAP similar genes for RLF Gene using alignment to 1 proteins: Pseudogenes for RLF Gene

genes like me logo Genes that share paralogs with RLF: view

Variants for RLF Gene

Sequence variations from dbSNP and Humsavar for RLF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35189918 - 40,236,705(-) AATCT(C/T)TGTCT reference, missense
rs35563960 - 40,237,497(-) CAAAG(A/G)CTTTC reference, missense
rs35042446 - 40,237,572(-) CAAAA(C/T)CACAG reference, missense
rs10889205 - 40,240,054(+) AAAGA(A/T)GATGA reference, missense
rs34123123 - 40,239,588(-) CACCC(A/G)GGGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RLF Gene

Variant ID Type Subtype PubMed ID
dgv49e1 CNV Complex 17122850
nsv829660 CNV Gain+Loss 17160897
nsv521874 CNV Loss 19592680
esv2673542 CNV Deletion 23128226
esv2747352 CNV Deletion 23290073

Variation tolerance for RLF Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RLF Gene

Disorders for RLF Gene

Relevant External Links for RLF

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RLF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RLF Gene

Publications for RLF Gene

  1. The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. (PMID: 8545128) Makela T.P. … Alitalo K. (Oncogene 1995) 3 4 23 67
  2. Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer. (PMID: 1649386) MAokelAo T.P. … Alitalo K. (Mol. Cell. Biol. 1991) 2 3 23
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. (PMID: 25505242) Fernandez J. … Arhel N.J. (J. Biol. Chem. 2015) 3
  5. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3

Products for RLF Gene

Sources for RLF Gene