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RLF Gene

protein-coding   GIFtS: 55
GCID: GC01P040627

Rearranged L-Myc Fusion

(Previous name: rearranged L-myc fusion sequence)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rearranged L-Myc Fusion1 2     ZN-15L2
Rearranged L-Myc Fusion Sequence1 2     ZNF292L2
Rearranged L-Myc Fusion Gene Protein2 3     Zinc Finger Protein Rlf2
Zn-15-Related Protein2 3     Zn-15 Related2

External Ids:    HGNC: 100251   Entrez Gene: 60182   Ensembl: ENSG000001170007   OMIM: 1806105   UniProtKB: Q131293   

Export aliases for RLF gene to outside databases

Previous GC identifers: GC01P040661 GC01P039630 GC01P040090 GC01P040040 GC01P040296 GC01P040399 GC01P038745


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RLF Gene:
RLF (rearranged L-myc fusion) is a protein-coding gene. An important paralog of this gene is ZNF292.

UniProtKB/Swiss-Prot: RLF_HUMAN, Q13129
Function: May be involved in transcriptional regulation

Gene Wiki entry for RLF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the RLF gene promoter:
         AhR   ATF-2   NCX/Ncx   XBP-1   Arnt   CREB   RORalpha1   CRE-BP1   COMP1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRLF promoter sequence
   Search Chromatin IP Primers for RLF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RLF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p32

RLF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RLF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P040627:  view genomic region     (about GC identifiers)

Start:
40,627,041 bp from pter      End:
40,706,593 bp from pter
Size:
79,553 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RLF_HUMAN, Q13129 (See protein sequence)
Recommended Name: Zinc finger protein Rlf  
Size: 1914 amino acids; 217953 Da
Subunit: Interacts with RIT1 and RIT2 (By similarity)
Miscellaneous: In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at
1p32 fusing the first exon of the RLF gene with L-myc
Secondary accessions: Q14CQ1 Q9NU60

Explore the universe of human proteins at neXtProt for RLF: NX_Q13129

Explore proteomics data for RLF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RLF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036553.2  
    ENSEMBL proteins: 
     ENSP00000361857  

    RLF Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q13129

    ProtoNet protein and cluster: Q13129

    1 Blocks protein domain: IPB007086 C2H2-type zinc finger signature

    UniProtKB/Swiss-Prot: RLF_HUMAN, Q13129
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 14 C2H2-type zinc fingers


    Find genes that share domains with RLF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RLF_HUMAN, Q13129
    Function: May be involved in transcriptional regulation

         Genatlas biochemistry entry for RLF:
    rearranged l-myc fusion gene,in small cell lung carcinoma

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS8545128
    GO:0005515protein binding IPI10545207
    GO:0008270zinc ion binding TAS8545128
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with RLF           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RLF:
     Increased S DNA content  Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rlf):
     growth/size/body  mortality/aging 

    Find genes that share phenotypes with RLF           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RLF
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    miRNA
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    miRTarBase miRNAs that target RLF:
    hsa-mir-182-5p (MIRT047185), hsa-mir-96-5p (MIRT027904), hsa-mir-877-3p (MIRT036823), hsa-mir-181a-5p (MIRT025096), hsa-mir-375 (MIRT019789), hsa-mir-17-5p (MIRT050968)

    Block miRNA regulation of human, mouse, rat RLF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RLF (see all 27):
    hsa-miR-142-3p hsa-miR-181c hsa-miR-29a hsa-miR-29c hsa-miR-764 hsa-miR-20b* hsa-miR-373* hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmidRLF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RLF

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RLF_HUMAN, Q13129: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC8545128

    Find genes that share ontologies with RLF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RLF
    Interactions:

        Search GeneGlobe Interaction Network for RLF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for RLF (Q131291, 2, 3 ENSP000003618574) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRPF40AO754002, 3MINT-61878 I2D: score=3 
    RIT1Q929631, 3, ENSP000003573064EBI-958266,EBI-365845 I2D: score=4 STRING: ENSP00000357306
    GCH1P307933, ENSP000003788904I2D: score=3 STRING: ENSP00000378890
    CNKSR2Q8WXI23, ENSP000003688244I2D: score=1 STRING: ENSP00000368824
    RIT2Q995783, ENSP000003218054I2D: score=3 STRING: ENSP00000321805
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS8545128
    GO:0009294DNA mediated transformation NAS8545128
    GO:0015074DNA integration IDA1851085
    GO:0045893positive regulation of transcription, DNA-templated ISS8545128

    Find genes that share ontologies with RLF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RLF



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RLF gene: 
    NM_012421.3  

    Unigene Cluster for RLF:

    Rearranged L-myc fusion
    Hs.205627  [show with all ESTs]
    Unigene Representative Sequence: NM_012421
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372771(uc001cfc.4 uc001cfd.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RLF (see all 27):
    hsa-miR-142-3p hsa-miR-181c hsa-miR-29a hsa-miR-29c hsa-miR-764 hsa-miR-20b* hsa-miR-373* hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmidRLF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RLF
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    GenScript: all cDNA clones in your preferred vector: RLF (NM_004491)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RLF
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RLF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RLF
      QuantiTect SYBR Green Assays in human, mouse, rat RLF
      QuantiFast Probe-based Assays in human, mouse, rat RLF

    Additional mRNA sequence: 

    AK307662.1 BC113666.1 BX537979.1 U22377.1 X58480.1 

    9 DOTS entries:

    DT.214756  DT.97800159  DT.95363715  DT.121437600  DT.121437615  DT.121437621  DT.121437628  DT.95262154 
    DT.100754512 

    Selected AceView cDNA sequences (see all 118):

    CB163941 AU130403 CB126178 BX956701 BU678115 BM806992 BM669568 AI826273 
    AW196684 AI803292 AW383138 F11598 BP339286 BM712271 AW274998 BM542854 
    AW102775 F12163 BM698782 AU140892 BF510798 AI076161 F09797 AW072336 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RLF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGTATATG
    RLF Expression
    About this image


    RLF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
    RLF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RLF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.205627

    UniProtKB/Swiss-Prot: RLF_HUMAN, Q13129
    Tissue specificity: Widely expressed in fetal and adult tissues

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RLF gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rlf1 , 5 rearranged L-myc fusion sequence1, 5 87.43(n)1
    89.1(a)1
      4 (56.80 cM)5
    1092631  NM_001081013.11  NP_001074482.11 
     1211458855 
    chicken
    (Gallus gallus)
    Aves RLF1 rearranged L-myc fusion 69.52(n)
    66.61(a)
      419573  XM_417721.4  XP_417721.4 
    lizard
    (Anolis carolinensis)
    Reptilia RLF6
    rearranged L-myc fusion
    56(a)
    1 ↔ 1
    GL343276.1(1767463-1785593)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.305672 Xenopus laevis transcribed sequence with moderate similarity more 74.78(n)    48046441 
    zebrafish
    (Danio rerio)
    Actinopterygii rlf1 rearranged L-myc fusion 51.9(n)
    43.65(a)
      562452  XM_685832.6  XP_690924.6 


    ENSEMBL Gene Tree for RLF (if available)
    TreeFam Gene Tree for RLF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RLF gene
    ZNF2922  ZNF6542  ENSG000002297292  
    1 SIMAP similar gene for RLF using alignment to 1 protein entry:     RLF_HUMAN:
    ZNF808

    Find genes that share paralogs with RLF           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RLF
    PGOHUM00000245666 PGOHUM00000235409


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RLF (see all 1722)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480247761,2
    C--40625083(+) CCACAG/TCTTTG 1 -- us2k10--------
    rs1923944331,2
    --40625225(+) GGTCTC/TGAACT 1 -- us2k10--------
    rs75188421,2
    C--40625252(+) cctccG/Cgcctt 1 -- us2k13Minor allele frequency- C:0.23NA WA 122
    rs1417267781,2
    --40625358(+) ACTATC/TTGTTT 1 -- us2k10--------
    rs352528151,2
    C--40625376(+) GTTTG-/TTTTTT 1 -- us2k10--------
    rs1848794461,2
    --40625704(+) TATGGC/TTGGGC 1 -- us2k10--------
    rs1505699251,2
    C--40625738(+) CAGCAA/CTTTGG 1 -- us2k10--------
    rs1508628391,2
    C--40626095(+) TTAAT-/ACAGTCA 1 -- us2k10--------
    rs44575631,2
    C--40626168(+) GGCGCG/AGTGGC 1 -- us2k12Minor allele frequency- A:0.25NA 4
    rs1123237541,2
    C--40626345(+) GAGGCAGG/-AGAAT 1 -- us2k11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for RLF (40627041 - 40706593 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RLF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673542CNV Deletion23128226
    esv2747352CNV Deletion23290073
    nsv521874CNV Loss19592680
    nsv829660CNV Gain+Loss17160897
    dgv49e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180610    OMIM disorders: --


    Find genes that share disorders with RLF           About GenesLikeMe

    2 Novoseek inferred disease relationships for RLF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 39.9 3 1312699 (2), 1649386 (1)
    tumors 0 2 1312699 (2)

    Genetic Association Database (GAD): RLF

    Export disorders for RLF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RLF gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with RLF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. (PubMed id 8545128)1, 2, 9 Makela T.P.... Alitalo K. (Oncogene 1995)
    2. Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer. (PubMed id 1649386)1, 3, 9 MAokelAo T.P....Alitalo K. (Mol. Cell. Biol. 1991)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6018 HGNC: 10025 AceView: RLF Ensembl:ENSG00000117000 euGenes: HUgn6018
    ECgene: RLF H-InvDB: RLF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RLF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RLF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RLF gene:
    Search GeneIP for patents involving RLF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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